Organic and Biological Chemistry

Research Output 1979 2019

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Chapter (peer-reviewed)
2019

Evaluation of the binding ability of an orphan nuclear receptor nurr1 to synthetic peptides.

Masuya, T., Tada, Y., Liu, X. & Matsushima, A., 2019, Peptide Science 2018. p. 133

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

2018

Homodimer function of human nuclear receptor ERR evidenced using -helix peptides in the dimer interface

Liu, X., Nakagawa, H., Sugiyama, M., Matsushima, A., Shimohigashi, M. & Shimohigashi, Y., 2018, Peptide Science 2017. p. 190 191 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Mutual co-work between nuclear receptor ERalpha and ERRgamma requires their homodimerization

Liu, X., Shimohigashi, M., Sugiyama, M., Matsushima, A. & Shimohigashi, Y., 2018, Peptide Science 2017,. p. 198 199 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Phe 2715.39 of Thronbin Receptor PAR-1 is a specific target of Phe-2-phenl group of its tethered ligand

Sugiyama, M., Fujita, T., Liu, X., Matsuyama, Y., Matsushima, A., Shimohigashi, M. & Shimohigashi, Y., 2018, Peptide Science 2017. p. 94 95 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

2017

Docking simulation to elucidate the labeled cysteine residue of the nociception receptor ORL1 using a Cys(Npys)-containing peptide ligand

Matsushima, A., Nishimura, H., Matsuyama, Y., Liu, X. & Shimohigashi, Y., 2017, Peptide Science 2016. p. 87-88

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

2016

Comparative analysis of the ligand binding domain secondary structures of human nuclear receptors

Matsuyama, Y., Nishimura, H., Liu, X., Matsushima, A. & Shimohigashi, Y., 2016, Peptide Science 2015. p. 337-338

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Comprehensive structural analysis of the nociceptin ORL1 receptor by means of virtual and experimental Ala-scanning combinated methods

Matsushima, A., Nishimura, H., Liu, X., Takesue, Y., Matsuyama, Y. & Shimohigashi, Y., 2016, Peptide Science 2015. p. 149-150

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Do the estrogen receptors function as a homodimer? experimental validation of homodimerization by inhibitory peptides

Sakito, S., Liu, X., Fujiyama, A., Matsushima, A. & Shimohigashi, Y., 2016, Peptide Science 2015. p. 335-336

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Do the estrogen receptors function as a homodimer? experimental validation of homodimerization by inhibitory peptides

Sakito, S., Fujiyama, A., Motomatsu, Y., Liu, X., Matsushima, A. & Shimohigashi, Y., 2016, Peptide Science 2015. p. 335-336

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Expression analysis of neuropeptide PDF mRNA in the hypoactive and hyperactive fruit flies Drosophila melanogaster

Asuka, T., Matsuo, A., Shotaro, U., Matsuyama, Y., masayuki, N., Sumiyoshi, M., Liu, X., Matsushima, A., Shimohigashi, M. & Shimohigashi, Y., 2016, Peptide Science 2015. p. 317-318

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Functional role of the Phe-Phe stacking microswitch in the ORL1 nociceptin receptor activation

Takesue, Y., Nishimura, H., Liu, X., Matsushima, A. & Shimohigashi, Y., 2016, Peptide Science 2015. p. 147-148

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

ORL1 Nociceptin receptor response of opioid peptides derived from proenkephalin precursor protein

Motomatsu, Y., Nishimura, H., Matsuyama, Y., Liu, X., Matsushima, A. & Shimohigashi, Y., 2016, Peptide Science 2015. p. 181-182

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

SCN Circadian rhythm signal transduction neuropeptides evoke hypoactive phenotype differently in male and female mice

Sugiyama, M., Motomatsu, Y., Matsuyama, Y., Kajiyama, S., Kameda, T., Uchimura, E., Saito, T., Liu, X., Matsushima, A. & Shimohigashi, Y., 2016, Peptide Science 2015. p. 53-54

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

2015

Alternative polyadenylation analyses of neuropeptide genes in bisphenol A-exposed hypoactive mouse brain

Sugiyama, M., Kajiyama, S., Saito, T., Uchimura, E., Motomatsu, Y., Matsuo, A., Matsushima, A. & Shimohigashi, Y., 2015, Peptide Science 2014. p. 345-346

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

An in silico genomic search of endomorphin-like opioid peptides

Matsushima, A., Koyanagi, K. O., Nishimura, H., Inamine, S., Motomatsu, Y. & Shimohigashi, Y., 2015, Peptide Science 2014. p. 281-282

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

A novel method identify and quantify the coactivator proteins that couple with human nuclear receptor: the use of interacting interface a-helix peptide for quantitative inhibition

Liu, X., Matsushima, A. & Shimohigashi, Y., 2015, Peptide Science 2014. p. 203-204

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Bisphenol A-induced substantial peak decay of Drosophila circadian neuropeptide hugin mRNA expression

Shotaro, U., Matsuo, A., Matsuyama, Y., Nakamura, M., Koga, K., Liu, X., Matsushima, A., Shimohigashi, M. & Shimohigashi, Y., 2015, Peptide Science 2014. p. 41-42

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

GPCR functional role of Phe-269 and Phe-221 in the molecular switching of ORL1 nociceptin receptor activation

Takesue, Y., Nishimura, H., Liu, X., Matsushima, A. & Shimohigashi, Y., 2015, Peptide Science 2014. p. 203-204

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Receptor selectivity and specificity of a series of opioid peptides latent in the proenkephalin precursor protein

Motomatsu, Y., Nishimura, H., Matsumoto, Y., Kuramitsu, Y., Inamine, S., Matsushima, A. & Shimohigashi, Y., 2015, Peptide Science 2014. p. 201-202

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Structural and molecular evolutionary analysis of the ligand-binding domain of forty-eight human nuclear receptors

Matsuyama, Y., Nishimura, H., Liu, X., Matsushima, A. & Shimohigashi, Y., 2015, Peptide Science 2014. p. 347-348

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Structure-activity Studies on the Halogenated Phe-containing Neuropeptide Substance P Analogs

Kuramitsu, Y., Nishimura, H., Nakamura, M., Suyama, K., Matsushima, A., Nose, T. & Shimohigashi, Y., 2015, Peptide Science 2014. p. 319-320

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

The molecular switching of ORL1 nociceptin receptor in activation/inactivation

Nishimura, H., Li, J., Isozaki, K., yuuki, T., Matsushima, A., Liu, X., Shimohigashi, M. & Shimohigashi, Y., 2015, Peptide Science 2014. p. 201-202

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

2014

Bisphenol A-induced Epigenetic Mutations in Circadian Pacemaker Neuropeptide mRNAs of Hyperactive Drosophila Fruit Flies

Matsuo, A., Umeno, S., Matsuyama, Y., Nakamura, M., Takeda, Y., Sumiyoshi, M., Liu, X., Matsushima, A., Shimohigashi, M. & Shimohigashi, Y., 2014, Peptide Science 2013. p. 457-458

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Constitutive α-Helix-peptides Required for Functional Dimerization of Estrogen-related Receptor γ (ERRγ).

Liu, X., Nishimura, H., Fujiyama, A., Matsushima, A. & Shimohigashi, Y., 2014, Peptide Science 2013. p. 429-430

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Expression and Mutation Analyses of Brain Neuropeptide Genes of Rndocrine-disrupting Bisphenol A-exposed Hypoactive Mouse

Sugiyama, M., Matsuo, A., Saito, T., Uchimura, E., Liu, X., Matsushima, A. & Shimohigashi, Y., 2014, Peptide Science 2013. p. 453-454

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Functionally Essential Amino Acid Residues in ORL1 Nociceptin Receptor for Ligand-stimulated Receptor Activation

Nishimura, H., Li, J., abe, Y., Isozaki, K., Matsushima, A., Inamine, S., Costa, T. & Shimohigashi, Y., 2014, Peptide Science 2013. p. 333-334

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Influence Analysis of the Circadian Evening Pacemaker Neuropeptide hugγ Gene in the Bisphenol A-exposed Fruit Fly Drosophila Brain

Umeno, S., Matsuo, A., Matsuyama, Y., Nakamura, M., Takeda, Y., Sumiyoshi, M., Liu, X., Matsushima, A. & Shimohigashi, Y., 2014, Peptide Science 2013. p. 455-456

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Multiple and Simultaneous Cys→Ala Mutations of ORL1 Nociceptin Receptor to Identify the Affinity Binding site of Cys(Npys)-Elongated RYYRIK Peptide Antagonist

Matsushima, A., Nishimura, H., Inamine, S. & Shimohigashi, Y., 2014, Peptide Science 2013. p. 413-414

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Specific Role of Phe Residues in Opioid Peptide Met-enkephalin- Arg-Phe in Binding to All Three Opioid Receptors

Motomatsu, Y., Nishimura, H., Matsumoto, Y., Inamine, S., Kuramitsu, Y., Matsushima, A. & Shimohigashi, Y., 2014, Peptide Science 2013. p. 317-318

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Structure-Activity Studies on the Halogenated Phe-containing Neuropeptide Substance P Analogs

Kuramitsu, Y., Nishimura, H., Nakamura, R., Suyama, K., Matsushima, A., Nose, T. & Shimohigashi, Y., Mar 2014, Peptide Science 2013. p. 319-320 2 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Three-dimensional Docking Modeling to Human Nuclear Receptors for Exploration of Bisphenol-A Targeting Receptors

Matsuyama, Y., Liu, X., Nishimura, H., Matsushima, A. & Shimohigashi, Y., 2014, Peptide Science 2013. p. 459-460

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

2013

Bisphenol-binding pocket of constitutively active nuclear receptor CAR: Docking modeling for close-packing

Matsuyama, Y., Liu, X., Nishimura, H., Matsushima, A., Nose, T. & Shimohigashi, Y., 2013, Peptide Science 2012. p. 401-402

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Exploration of pharmacological chaperone for rescue of misfolded and/or unfolded ORL1 nociceptin receptor proteins

Nishimura, H., Inamine, S., Li, J., Matsushima, A. & Shimohigashi, Y., 2013, Peptide Science 2012. p. 115-118

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Halogenated Phe-containing endomorphin-2 analogs with mixed agonist and antagonist activities

Nishio, K., Nishimura, H., Suyama, K., Matsushima, A., Nose, T. & Shimohigashi, Y., 2013, Peptide Science 2012. p. 25-26

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

High-precision binding assay procedure of tachykinin receptor NK-1 for highly potent Substance P analogs

Kuramitsu, Y., Nishimura, H., Nakamura, R., Suyama, K., Matsushima, A., Nose, T. & Shimohigashi, Y., 2013, Peptide Science 2012. p. 213-214

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Identification of affinity binding site of Cys(Npys)-elongated RYYRIK peptide antagonist by means of Cys→Ala mutated ORL1 nociceptin receptors

Matsushima, A., Nishimura, H., Inamine, S. & Shimohigashi, Y., 2013, Peptide Science 2012. p. 207-208

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

The impact of bisphenol A-feeding on the Drosophila neuropeptide PDF mRNA structure

Matsuo, A., Nakamura, M., Takeda, Y., Matsuyama, Y., Sumiyoshi, M., Liu, X., Matsushima, A., Shimohigashi, M. & Shimohigashi, Y., 2013, Peptide Science 2012. p. 75-76

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Two different binding modes of peptide library-based antagonist acyl-RYYRIK amide in the orl1 nociceptin receptor

Inamine, S., Nishimura, H., Li, J., Matsushima, A., Costa, T. & Shimohigashi, Y., 2013, Peptide Science 2012. p. 229-230

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

2012

Affinity labeling of the ORL1 nociceptin receptor by Cys(Npys)-elongated RYYRIK peptide antagonist

Matsushima, A., Nishimura, H., Uemura, S., Li, J., Inamine, S. & Shimohigashi, Y., 2012, Peptide Science 2011. p. 179-180

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Effects of the halogenation of Phe-phenyl group of two consecutive residues in endomorphin-2 on the interaction with the μ–opioid receptors

Nishio, K., Nishimura, H., Suyama, K., Abe, Y., Matsushima, A., Nose, T. & Shimohigashi, Y., 2012, Peptide Science 2011. p. 171-172

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Receptor Binding Characteristics of Tritium-labeled Pure antagonist Peptide for Hyperalgesic nociceptin ORL1 receptor

Inamine, S., Nishimura, H., Li, J., Matsushima, A., Nose, T., Costa, T. & Shimohigashi, Y., 2012, Peptide Science 2011. p. 183-184

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Structural Analysis of Delta Opioid Receptor Dimer by Bivalent Deltorphin II Analogs

Ito, N., Nishimura, H., Matsushima, A., Nose, T., Costa, T. & Shimohigashi, Y., Mar 2012, Peptide Science 2011. p. 173-174 2 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Structural Characteristics of Thr-Gly Dipeptide Repeat in the Drosophila Clock Protein PERIOD

Matsuo, A., Nishimura, H., Masayuki, N., Koga, K., Sumiyoshi, M., Matsushima, A., Nose, T., Shimohigashi, M. & Shimohigashi, Y., Mar 2012, Peptide Science 2011. p. 351-352 2 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Structural Essentials of Hyperalgesic Nociceptin ORL1 Receptor for Ligand Binding and Receptor Activation

Nishimura, H., Li, J., Isozaki, K., Abe, Y., Inamine, S., Matsushima, A., Nose, T., Costa, T. & Shimohigashi, Y., 2012, Peptide Science 2011. p. 33-34

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

2011

Exploration of the binding site of ORL1 nociceptin receptor antagonist

Inamine, S., Nishimura, H., Matsushima, A., Nose, T., Costa, T. & Shimohigashi, Y., 2011, Peptide Science 2010. p. 167

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

QCM-analyses of the intermolecular interaction between prion protein N-terminal domains having increased number of octapeptide repeat.

Sato, K., Horiuchi, Y., Matsushima, A. & Shimohigashi, Y., 2011, Peptide Science 2010. p. 128

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Structural essentials of hyperalgesic nococeptin ORL1 receptor for ligand binding and receptor activation

Nishimura, H., Li, J., Isozaki, K., Abe, Y., Inamine, S., Matsushima, A., Nose, T., Costa, T. & Shimohigashi, Y., 2011, Peptide Science 2010. p. 128

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

The Trp Residue of Opioid Receptor TM5 is Present at the Cell Membrane Interface as a Molecular Anchor for Full Activation

Nishimura, H., Li, J., Inokuchi, N., Koikawa, S., Nose, T., Matsushima, A., Costa, T. & Shimohigashi, Y., Mar 2011, Peptide Science 2010. p. 175 1 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

2010

Functional role of the C-terminal Helix 12 peptide in the receptor activation mechanism of estrogen-related receptor γ (ERRγ)

Liu, X., Matsushima, A., Nose, T., Okada, H. & Shimohigashi, Y., 2010, Peptide Science 2009. p. 435–436

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Identification of circadian neuropeptide PDF mRNA isoforms in the housefly Musca domestica

Kawanaka, C., Matsushima, A., Takeda, Y., Shimohigashi, M. & Shimohigashi, Y., 2010, Peptide Science 2009. p. 145–146

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)