Research Output 2001 2019

2019

Ccr7 null mice are protected against diet-induced obesity via Ucp1 upregulation and enhanced energy expenditure

Sano, T., Sanada, T., Sotomaru, Y., Shinjo, T., Iwashita, M., Yamashita, A., Fukuda, T., Sanui, T., Asano, T., Kanematsu, T. & Nishimura, F., Jul 4 2019, In : Nutrition and Metabolism. 16, 1, 43.

Research output: Contribution to journalArticle

Open Access
Energy Metabolism
Up-Regulation
Obesity
Diet
White Adipose Tissue

Dental pulp cell-derived powerful inducer of TNF-α comprises PKR containing stress granule rich microvesicles

Suzuki, S., Fukuda, T., Nagayasu, S., Nakanishi, J., Yoshida, K., Hirata-Tsuchiya, S., Nakao, Y., Sano, T., Yamashita, A., Yamada, S., Ohta, K., Shiba, H. & Nishimura, F., Dec 1 2019, In : Scientific reports. 9, 1, 3825.

Research output: Contribution to journalArticle

Open Access
Dental Pulp
Macrophages
Proteins
Gene Silencing
p38 Mitogen-Activated Protein Kinases
2018
4 Citations (Scopus)

Adipose tissue complement factor B promotes adipocyte maturation

Matsunaga, H., Iwashita, M., Shinjo, T., Yamashita, A., Tsuruta, M., Nagasaka, S., Taniguchi, A., Fukushima, M., Watanabe, N. & Nishimura, F., Jan 1 2018, In : Biochemical and Biophysical Research Communications. 495, 1, p. 740-748 9 p.

Research output: Contribution to journalArticle

Complement Factor B
Thromboplastin
Adipocytes
Adipose Tissue
Tissue
1 Citation (Scopus)

Metabolic Endotoxemia-Activated Macrophages Promote Pancreatic β Cell Death via IFNβ-Xaf1 Pathway

Tsuruta, M., Iwashita, M., Shinjo, T., Matsunaga, H., Yamashita, A. & Nishimura, F., Feb 1 2018, In : Hormone and Metabolic Research. 50, 2, p. 160-167 8 p.

Research output: Contribution to journalArticle

Endotoxemia
Macrophages
Cell death
Interferons
Cell Death
1 Citation (Scopus)

Sprouty2 is involved in the control of osteoblast proliferation and differentiation through the FGF and BMP signaling pathways

Taketomi, T., Onimura, T., Yoshiga, D., Muratsu, D., Sanui, T., Fukuda, T., Kusukawa, J. & Nakamura, S., Sep 2018, In : Cell Biology International. 42, 9, p. 1106-1114 9 p.

Research output: Contribution to journalArticle

Bone Morphogenetic Proteins
Fibroblast Growth Factors
Osteoblasts
Mitogen-Activated Protein Kinase 3
Mitogen-Activated Protein Kinase 1
2017
2 Citations (Scopus)

Adhesion attenuates respiratory burst induced by different modes of triggering in resting or LPS-primed neutrophils

Sanui, T., Takeshita, M., Fukuda, T., Tanaka, U., Alshargabi, R., Aida, Y. & Nishimura, F., Aug 1 2017, In : Immunobiology. 222, 8-9, p. 865-871 7 p.

Research output: Contribution to journalArticle

Respiratory Burst
Neutrophils
methionyl-leucyl-phenylalanine
Vitronectin
Fibrinogen
2 Citations (Scopus)

Amelogenin induces M2 macrophage polarisation via PGE2/cAMP signalling pathway

Yamamichi, K., Fukuda, T., Sanui, T., Toyoda, K., Tanaka, U., Nakao, Y., Yotsumoto, K., Yamato, H., Taketomi, T., Uchiumi, T. & Nishimura, F., Nov 1 2017, In : Archives of Oral Biology. 83, p. 241-251 11 p.

Research output: Contribution to journalArticle

Amelogenin
Dinoprostone
Macrophages
Anti-Inflammatory Agents
Microarray Analysis
5 Citations (Scopus)

Angiopoietin-like protein 2 is a positive regulator of osteoblast differentiation

Takano, A., Fukuda, T., Shinjo, T., Iwashita, M., Matsuzaki, E., Yamamichi, K., Takeshita, M., Sanui, T. & Nishimura, F., Apr 1 2017, In : Metabolism: Clinical and Experimental. 69, p. 157-170 14 p.

Research output: Contribution to journalArticle

Angiopoietins
Osteoblasts
Proteins
RNA
Adipocytes

Antibiotic effects against periodontal bacteria in organ cultured tissue

Takeshita, M., Haraguchi, A., Miura, M., Hamachi, T., Fukuda, T., Sanui, T., Takano, A. & Nishimura, F., Feb 1 2017, In : Clinical and Experimental Dental Research. 3, 1, p. 5-12 8 p.

Research output: Contribution to journalArticle

Epithelium
Anti-Bacterial Agents
Bacteria
cefdinir
Periodontitis
1 Citation (Scopus)
Anti-Idiotypic Antibodies
Neutrophils
Toll-Like Receptor 4
Superoxides
Lipids
6 Citations (Scopus)

Epicatechin downregulates adipose tissue CCL19 expression and thereby ameliorates diet-induced obesity and insulin resistance

Sano, T., Nagayasu, S., Suzuki, S., Iwashita, M., Yamashita, A., Shinjo, T., Sanui, T., Kushiyama, A., Kanematsu, T., Asano, T. & Nishimura, F., Mar 1 2017, In : Nutrition, Metabolism and Cardiovascular Diseases. 27, 3, p. 249-259 11 p.

Research output: Contribution to journalArticle

Catechin
Insulin Resistance
Adipose Tissue
Down-Regulation
Obesity
4 Citations (Scopus)
Porphyromonas gingivalis
Neutrophils
Toll-Like Receptor 4
Respiratory Burst
Interleukin-1

Roles of serum in innate immune responses of human leukocytes to synthetic lipopeptide

Sanui, T., Takeshita, M., Fukuda, T., Tanaka, U., Alshargabi, R., Aida, Y. & Nishimura, F., Sep 1 2017, In : International Immunopharmacology. 50, p. 61-68 8 p.

Research output: Contribution to journalArticle

Lipopeptides
Innate Immunity
Leukocytes
Respiratory Burst
Serum
2016

Antibiotic effects against periodontal bacteria in organ cultured tissue

Takeshita, M., Haraguchi, A., Miura, M., Hamachi, T., Fukuda, T., Sanui, T., Takano, A. & Nishimura, F., Nov 2016, (Accepted/In press) In : Clinical and Experimental Dental Research.

Research output: Contribution to journalArticle

5 Citations (Scopus)
HDL Lipoproteins
Superoxides
Lipopolysaccharides
Albumins
Hemoglobins
2 Citations (Scopus)

Grp78 Is Critical for Amelogenin-Induced Cell Migration in a Multipotent Clonal Human Periodontal Ligament Cell Line

Toyoda, K., Fukuda, T., Sanui, T., Tanaka, U., Yamamichi, K., Atomura, R., Maeda, H., Tomokiyo, A., Taketomi, T., Uchiumi, T. & Nishimura, F., Jan 1 2016, In : Journal of Cellular Physiology. 231, 2, p. 414-427 14 p.

Research output: Contribution to journalArticle

Amelogenin
Periodontal Ligament
Ligaments
Cell Movement
Cells

IL-17A synergistically enhances TNFα-induced IL-6 and CCL20 production in 3T3-L1 adipocytes

Shinjo, T., Iwashita, M., Yamashita, A., Sano, T., Tsuruta, M., Matsunaga, H., Sanui, T., Asano, T. & Nishimura, F., Aug 19 2016, In : Biochemical and Biophysical Research Communications. 477, 2, p. 241-246 6 p.

Research output: Contribution to journalArticle

Interleukin-17
Adipocytes
Interleukin-6
Macrophages
Adipose Tissue
5 Citations (Scopus)

Inhibition of sprouty2 polarizes macrophages toward an M2 phenotype by stimulation with interferon γ and Porphyromonas gingivalis lipopolysaccharide

Atomura, R., Sanui, T., Fukuda, T., Tanaka, U., Toyoda, K., Taketomi, T., Yamamichi, K., Akiyama, H. & Nishimura, F., Jan 1 2016, In : Immunity Inflammation and Disease. 4, 1, p. 98-110 13 p.

Research output: Contribution to journalArticle

Open Access
Porphyromonas gingivalis
Interferons
Lipopolysaccharides
Macrophages
Phenotype
8 Citations (Scopus)

Investigation of the functional role of human Interleukin-8 gene haplotypes by CRISPR/Cas9 mediated genome editing

Benakanakere, M. R., Finoti, L. S., Tanaka, U., Grant, G. R., Scarel-Caminaga, R. M. & Kinane, D. F., Aug 8 2016, In : Scientific reports. 6, 31180.

Research output: Contribution to journalArticle

Clustered Regularly Interspaced Short Palindromic Repeats
Interleukin-8
Haplotypes
Genes
Single Nucleotide Polymorphism
3 Citations (Scopus)

Mechanisms of the Macrolide-Induced Inhibition of Superoxide Generation by Neutrophils

Nozoe, K., Aida, Y., Fukuda, T., Sanui, T. & Nishimura, F., Jun 1 2016, In : Inflammation. 39, 3, p. 1039-1048 10 p.

Research output: Contribution to journalArticle

Macrolides
Azithromycin
Superoxides
Neutrophils
N-Formylmethionine Leucyl-Phenylalanine
2015
29 Citations (Scopus)

DPP-IV inhibitor anagliptin exerts anti-inflammatory effects on macrophages, adipocytes, and mouse livers by suppressing NF-κB activation

Shinjo, T., Nakatsu, Y., Iwashita, M., Sano, T., Sakoda, H., Ishihara, H., Kushiyama, A., Fujishiro, M., Fukushima, T., Tsuchiya, Y., Kamata, H., Nishimura, F. & Asano, T., Jan 1 2015, In : American Journal of Physiology - Endocrinology and Metabolism. 309, 3, p. E214-E223

Research output: Contribution to journalArticle

Adipocytes
Anti-Inflammatory Agents
Macrophages
Lipopolysaccharides
Liver
7 Citations (Scopus)

High-fat diet feeding significantly attenuates anagliptin-induced regeneration of islets of Langerhans in streptozotocin-induced diabetic mice

Shinjo, T., Nakatsu, Y., Iwashita, M., Sano, T., Sakoda, H., Ishihara, H., Kushiyama, A., Fujishiro, M., Nishimura, F. & Asano, T., Jun 2 2015, In : Diabetology and Metabolic Syndrome. 7, 1, 50.

Research output: Contribution to journalArticle

High Fat Diet
Streptozocin
Islets of Langerhans
Regeneration
Serum
6 Citations (Scopus)

Mutation of Spry2 Induces Proliferation and Differentiation of Osteoblasts but Inhibits Proliferation of Gingival Epithelial Cells

Sanui, T., Tanaka, U., Fukuda, T., Toyoda, K., Taketomi, T., Atomura, R., Yamamichi, K. & Nishimura, F., Apr 1 2015, In : Journal of Cellular Biochemistry. 116, 4, p. 628-639 12 p.

Research output: Contribution to journalArticle

Osteoblasts
Fibroblast Growth Factor 2
Epidermal Growth Factor
Epithelial Cells
Tissue regeneration
15 Citations (Scopus)

Prolyl isomerase Pin1 negatively regulates AMP-activated protein kinase (AMPK) by associating with the CBS domain in the γ subunit

Nakatsu, Y., Iwashita, M., Sakoda, H., Ono, H., Nagata, K., Matsunaga, Y., Fukushima, T., Fujishiro, M., Kushiyama, A., Kamata, H., Takahashi, S. I., Katagiri, H., Honda, H., Kiyonari, H., Uchida, T. & Asano, T., Oct 2 2015, In : Journal of Biological Chemistry. 290, 40, p. 24255-24266 12 p.

Research output: Contribution to journalArticle

Peptidylprolyl Isomerase
AMP-Activated Protein Kinases
Phosphorylation
Biguanides
Mitochondria
14 Citations (Scopus)

Protection from diet-induced obesity and insulin resistance in mice lacking CCL19-CCR7 signaling

Sano, T., Iwashita, M., Nagayasu, S., Yamashita, A., Shinjo, T., Hashikata, A., Asano, T., Kushiyama, A., Ishimaru, N., Takahama, Y. & Nishimura, F., Jul 1 2015, In : Obesity. 23, 7, p. 1460-1471 12 p.

Research output: Contribution to journalArticle

Insulin Resistance
Obesity
Diet
Obese Mice
Endotoxins
2 Citations (Scopus)

Sprouty2 inhibition promotes proliferation and migration of periodontal ligament cells

Tanaka, U., Sanui, T., Fukuda, T., Toyoda, K., Taketomi, T., Atomura, R., Yamamichi, K., Maeda, H. & Nishimura, F., Nov 1 2015, In : Oral Diseases. 21, 8, p. 977-986 10 p.

Research output: Contribution to journalArticle

Periodontal Ligament
Fibroblast Growth Factor 2
Epidermal Growth Factor
Small Interfering RNA
Cell Movement
2013
11 Citations (Scopus)

Identification of Novel Amelogenin-Binding Proteins by Proteomics Analysis

Fukuda, T., Sanui, T., Toyoda, K., Tanaka, U., Taketomi, T., Uchiumi, T. & Nishimura, F., Oct 22 2013, In : PloS one. 8, 10, e78129.

Research output: Contribution to journalArticle

Amelogenin
Proteomics
proteomics
binding proteins
Carrier Proteins

Valsartan restores inflammatory response by macrophages in adipose and hepatic tissues of LPS-infused mice

Iwashita, M., Nakatsu, Y., Sakoda, H., Fujishiro, M., Kushiyama, A., Fukushima, T., Kumamoto, S., Shinjo, T., Kamata, H., Nishimura, F. & Asano, T., Jan 1 2013, In : Adipocyte. 2, 1, p. 28-32 5 p.

Research output: Contribution to journalArticle

Valsartan
Lipopolysaccharides
Insulin Resistance
Adipose Tissue
Macrophages
2011
34 Citations (Scopus)

Sprouty2 controls proliferation of palate mesenchymal cells via fibroblast growth factor signaling

Matsumura, K., Taketomi, T., Yoshizaki, K., Arai, S., Sanui, T., Yoshiga, D., Yoshimura, A. & Nakamura, S., Jan 28 2011, In : Biochemical and Biophysical Research Communications. 404, 4, p. 1076-1082 7 p.

Research output: Contribution to journalArticle

Fibroblast Growth Factors
Palate
Cell proliferation
Cleft Palate
Cell Proliferation
2009
12 Citations (Scopus)

Analysis of Streptococcus mutans biofilm proteins recognized by salivary immunoglobulin A

Sanui, T. & Gregory, R. L., Oct 2009, In : Oral Microbiology and Immunology. 24, 5, p. 361-368 8 p.

Research output: Contribution to journalArticle

Salivary Proteins and Peptides
Streptococcus mutans
Biofilms
Saliva
Immunoglobulin A
2006
24 Citations (Scopus)

DOCK2 is required in T cell precursors for development of Vα14 NK T cells

Kunisaki, Y., Tanaka, Y., Sanui, T., Inayoshi, A., Noda, M., Nakayama, T., Harada, M., Taniguchi, M., Sasazuki, T. & Fukui, Y., Apr 15 2006, In : Journal of Immunology. 176, 8, p. 4640-4645 6 p.

Research output: Contribution to journalArticle

T-Lymphoid Precursor Cells
Natural Killer T-Cells
Natural Killer Cells
T-Lymphocytes
Thymus Gland
62 Citations (Scopus)

YB-1 is important for an early stage embryonic development: Neural tube formation and cell proliferation

Uchiumi, T., Fotovati, A., Sasaguri, T., Shibahara, K., Shimada, T., Fukuda, T., Nakamura, T., Izumi, H., Tsuzuki, T., Kuwano, M. & Kohno, K., Dec 29 2006, In : Journal of Biological Chemistry. 281, 52, p. 40440-40449 10 p.

Research output: Contribution to journalArticle

Neural Tube
Cell proliferation
Fibroblasts
Embryonic Development
Actins
2005
26 Citations (Scopus)

Deletion of DOCK2, a regulator of the actin cytoskeleton in lymphocytes, suppresses cardiac allograft rejection

Jiang, H., Pan, F., Erickson, L. M., Jang, M. S., Sanui, T., Kunisaki, Y., Sasazuki, T., Kobayashi, M. & Fukui, Y., Oct 17 2005, In : Journal of Experimental Medicine. 202, 8, p. 1121-1130 10 p.

Research output: Contribution to journalArticle

Actin Cytoskeleton
Allografts
Lymphocytes
T-Lymphocytes
Immunological Synapses
2004
29 Citations (Scopus)

Characterization of the 5′-untranslated region of YB-1 mRNA and autoregulation of translation by YB-1 protein

Fukuda, T., Ashizuka, M., Nakamura, T., Shibahara, K., Maeda, K., Izumi, H., Kohno, K., Kuwano, M. & Uchiumi, T., Mar 10 2004, In : Nucleic acids research. 32, 2, p. 611-622 12 p.

Research output: Contribution to journalArticle

5' Untranslated Regions
Protein Biosynthesis
Homeostasis
Proteins
Messenger RNA
87 Citations (Scopus)

Defective fetal liver erythropoiesis and T lymphopoiesis in mice lacking the phosphatidylserine receptor

Kunisaki, Y., Masuko, S., Noda, M., Inayoshi, A., Sanui, T., Harada, M., Sasazuki, T. & Fukui, Y., May 1 2004, In : Blood. 103, 9, p. 3362-3364 3 p.

Research output: Contribution to journalArticle

Lymphopoiesis
Erythropoiesis
Liver
Cells
Thymus
37 Citations (Scopus)

Targeted disruption of one allele of the Y-box binding protein-1 (YB-1) gene in mouse embryonic stem cells and increased sensitivity to cisplatin and mitomycin C

Shibahara, K., Uchiumi, T., Fukuda, T., Kura, S., Tominaga, Y., Maehara, Y., Kohno, K., Nakabeppu, Y., Tsuzuki, T. & Kuwano, M., Apr 1 2004, In : Cancer Science. 95, 4, p. 348-353 6 p.

Research output: Contribution to journalArticle

Y-Box-Binding Protein 1
Mitomycin
Cisplatin
Alleles
Genes
2003
90 Citations (Scopus)

DOCK2 is essential for antigen-induced translocation of TCR and lipid rafts, but not PKC-θ and LFA-1, in T cells

Sanui, T., Inayoshi, A., Noda, M., Iwata, E., Oike, M., Sasazuki, T. & Fukui, Y., Jul 1 2003, In : Immunity. 19, 1, p. 119-129 11 p.

Research output: Contribution to journalArticle

Lymphocyte Function-Associated Antigen-1
T-Lymphocytes
Actin Cytoskeleton
Lipids
Antigens
75 Citations (Scopus)

DOCK2 regulates Rac activation and cytoskeletal reorganization through interaction with ELMO1

Sanui, T., Inayoshi, A., Noda, M., Iwata, E., Stein, J. V., Sasazuki, T. & Fukui, Y., Oct 15 2003, In : Blood. 102, 8, p. 2948-2950 3 p.

Research output: Contribution to journalArticle

Lymphocytes
Chemical activation
Infiltration
Actins
Association reactions
2002
74 Citations (Scopus)

Binding capacity of human YB-1 protein for RNA containing 8-oxoguanine

Hayakawa, H., Uchiumi, T., Fukuda, T., Ashizuka, M., Kohno, K., Kuwano, M. & Sekiguchi, M., Oct 22 2002, In : Biochemistry. 41, 42, p. 12739-12744 6 p.

Research output: Contribution to journalArticle

RNA
Proteins
Y-Box-Binding Protein 1
Nucleotides
Paraquat
49 Citations (Scopus)

Novel translational control through an iron-responsive element by interaction of multifunctional protein YB-1 and IRP2

Ashizuka, M., Fukuda, T., Nakamura, T., Shirasuna, K., Iwai, K., Izumi, H., Kohno, K., Kuwano, M. & Uchiumi, T., Sep 1 2002, In : Molecular and cellular biology. 22, 18, p. 6375-6383 9 p.

Research output: Contribution to journalArticle

Iron Regulatory Protein 2
Iron
Proteins
Messenger RNA
Ferritins
2001
331 Citations (Scopus)

Haematopoietic cell-specific CDM family protein DOCK2 is essential for lymphocyte migration

Fukui, Y., Hashimoto, O., Sanui, T., Oono, T., Koga, H., Abe, M., Inayoshi, A., Noda, M., Oike, M., Shirai, T. & Sasazuki, T., Aug 23 2001, In : Nature. 412, 6849, p. 826-831 6 p.

Research output: Contribution to journalArticle

Myoblasts
Lymphocytes
Chemokines
Cell Movement
Actins
18 Citations (Scopus)

Organ-specific autoimmunity in mice whose T cell repertoire is shaped by a single antigenic peptide

Oono, T., Fukui, Y., Masuko, S., Hashimoto, O., Ueno, T., Sanui, T., Inayoshi, A., Noda, M., Sata, M. & Sasazuki, T., Dec 29 2001, In : Journal of Clinical Investigation. 108, 11, p. 1589-1596 8 p.

Research output: Contribution to journalArticle

Autoimmunity
T-Lymphocytes
Peptides
Autoimmune Diseases of the Nervous System
Experimental Autoimmune Neuritis