Research Output

1992

Isolation and sequencing of a cDNA clone encoding the 85 kDa human lysosomal sialoglycoprotein (hLGP85) in human metastatic pancreas islet tumor cells

Fujita, H., Takata, Y., Kono, A., Tanaka, Y., Takahashi, T., Himeno, M. & Kato, K., Apr 30 1992, In : Biochemical and Biophysical Research Communications. 184, 2, p. 604-611 8 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

Possible involvement of cathepsin L in processing of rat liver hexokinase to eliminate mitochondria-binding ability

Okazaki, H., Tanl, C., Ando, M., Ishii, K., Ishibashi, S., Nishimura, Y. & Kato, K., Jan 1 1992, In : Journal of biochemistry. 112, 3, p. 409-413 5 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Structures of four new triterpenoid oligoglycosides: DS-penaustrosides A, B, C, and D from the sea cucumber pentacta australis

Miyamoto, T., Togawa, K., Higuchi, R., Komori, T. & Sasaki, T., Jul 1 1992, In : Journal of Natural Products. 55, 7, p. 940-946 7 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)

Three new cytotoxic sesterterpenoids, inorolide A, B, and C from the nudibranch Chromodoris inornata

Miyamoto, T., Sakamoto, K., Amano, H., Higuchi, R., Komori, T. & Sasaki, T., Sep 22 1992, In : Tetrahedron Letters. 33, 39, p. 5811-5814 4 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)
1991

1H-NMR study of the intramolecular interaction of a substrate analogue covalently attached to aspartic acid-101 in lysozyme

Ueda, T., Isakari, Y., Aoki, H., Yasukochi, T., Masutomo, S. I., Kawano, K., Terada, Y., Yamada, H. & Imoto, T., Jan 1 1991, In : Journal of Biochemistry. 109, 5, p. 690-698 9 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Bafilomycin A1 inhibits the targeting of lysosomal acid hydrolases in cultured hepatocytes

Oda, K., Nishimura, Y., Ikehara, Y. & Kato, K., Jul 15 1991, In : Biochemical and Biophysical Research Communications. 178, 1, p. 369-377 9 p.

Research output: Contribution to journalArticle

42 Citations (Scopus)

Isolation and sequencing of a cDNA clone encoding rat liver lysosomal cathepsin D and the structure of three forms of mature enzymes

Fujita, H., Tanaka, Y., Noguchi, Y., Kono, A., Himeno, M. & Kato, K., Aug 30 1991, In : Biochemical and Biophysical Research Communications. 179, 1, p. 190-196 7 p.

Research output: Contribution to journalArticle

35 Citations (Scopus)

Mechanisms of a conversion from membrane associated lysosomal acid phosphatase to content forms

Himeno, M., Nakamura, K., Tanaka, Y., Yamada, H., Imoto, T. & Kato, K., Nov 14 1991, In : Biochemical and Biophysical Research Communications. 180, 3, p. 1483-1489 7 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Multiple proteolytic action of rat liver cathepsin B: Specificities and pH-dependences of the endo- and exopeptidase activities

Koga, H., Yamada, H., Nishimura, Y., Kato, K. & Imoto, T., Jan 1 1991, In : Journal of Biochemistry. 110, 2, p. 179-188 10 p.

Research output: Contribution to journalArticle

35 Citations (Scopus)

Preparation and properties of a lysozyme derivative in which two domains are cross-linked intramolecularly between trp62 and asp101

Ueda, T., Yamada, H., Sakamoto, N., Abe, Y., Kawano, K., Terada, Y. & Imoto, T., Jan 1 1991, In : Journal of biochemistry. 110, 5, p. 719-725 7 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Rat cathepsin H-catalyzed transacylation: Comparisons of the mechanism and the specificity with papain-superfamily proteases

Koga, H., Mori, N., Yamada, H., Nishimura, Y., Tokuda, K., Kato, K. & Imoto, T., Jan 1 1991, In : Journal of Biochemistry. 110, 6, p. 939-944 6 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)
1990

Augmented excretion of procathepsin L of a fos-transferred highly metastatic rat cell line

Taniguchi, S., Nishimura, Y., Takahashi, T., Baba, T. & Kato, K., Apr 30 1990, In : Biochemical and Biophysical Research Communications. 168, 2, p. 520-526 7 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

Biosythesis processing, and intracellular transport of lysosomal acid phosphatase in rat hepatocytes

Tanaka, Y., Harada, R., Himeno, M. & Kato, K., Jan 1 1990, In : Journal of biochemistry. 108, 2, p. 278-286 9 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

Characterization of a mutation in a family with saposin B deficiency: a glycosylation site defect

Kretz, K. A., Carson, G. S., Morimoto, S., Kishimoto, Y., Fluharty, A. L. & O'Brien, J. S., Apr 1990, In : Proceedings of the National Academy of Sciences of the United States of America. 87, 7, p. 2541-4 4 p.

Research output: Contribution to journalArticle

103 Citations (Scopus)

Comparative study on specificities of rat cathepsin L and papain: Amino acid differences at substrate-binding sites are involved in their specificities

Koga, H., Yamada, H., Nishimura, Y., Kato, K. & Imoto, T., Jan 1 1990, In : Journal of Biochemistry. 108, 6, p. 976-982 7 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

Constituents of holothuroidea, I. Isolation and structures of three triterpenoid aglycones, cucumechinol A, B, and C, from the sea cucumber Cucumaria echinata

Miyamoto, T., Togawa, K., Higuchi, R. & Komori, T., Jan 1 1990, In : Liebigs Annalen der Chemie. 1990, 1, p. 39-42 4 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Constituents of holothuroidea, II. Six newly identified biologically active triterpenoid glycoside sulfates from the sea cucumber Cucumaria echinata

Miyamoto, T., Togawa, K., Higuchi, R., Komori, T. & Sasaki, T., Jan 1 1990, In : Liebigs Annalen der Chemie. 1990, 5, p. 453-460 8 p.

Research output: Contribution to journalArticle

44 Citations (Scopus)

Determination of saposin proteins (sphingolipid activator proteins) in human tissues

Morimoto, S., Yamamoto, Y., O'Brien, J. S. & Kishimoto, Y., Nov 1 1990, In : Analytical Biochemistry. 190, 2, p. 154-7 4 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)
58 Citations (Scopus)

Effect of chemical modifications of tryptophan residues on the folding of reduced hen egg-white lysozyme

Ueda, T., Yamada, H., Aoki, H. & Imoto, T., Jan 1 1990, In : Journal of Biochemistry. 108, 5, p. 886-892 7 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Immunocytochemical study of the surrounding envelope of autophagic vacuoles in cultured rat hepatocytes

Furuno, K., Ishikawa, T., Akasaki, K., Lee, S., Nishimura, Y., Tsuji, H., Himeno, M. & Kato, K., Jan 1 1990, In : Experimental Cell Research. 189, 2, p. 261-268 8 p.

Research output: Contribution to journalArticle

45 Citations (Scopus)

Immunoenzyme localization of cathepsins in the Golgi region of rat hepatocytes and renal tubule cells

Yokota, S., Nishimura, Y., Kawabata, T. & Kato, K., Nov 1 1990, In : Histochemistry. 94, 6, p. 629-635 7 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Inhibition of intracellular sorting and processing of lysosomal cathepsins H and L at reduced temperature in primary cultures of rat hepatocytes

Nishimura, Y., Kawabata, T., Yano, S. & Kato, K., Jan 1 1990, In : Archives of Biochemistry and Biophysics. 283, 2, p. 458-463 6 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)

Interaction of saposins, acidic lipids, and glucosylceramidase

Morimoto, S., Kishimoto, Y., Tomich, J., Weiler, S., Ohashi, T., Barranger, J. A., Kretz, K. A. & O'Brien, J. S., Feb 5 1990, In : Journal of Biological Chemistry. 265, 4, p. 1933-7 5 p.

Research output: Contribution to journalArticle

59 Citations (Scopus)

Lysosomal acid phosphatase is transported via endosomes to lysosomes

Tanaka, Y., Yano, S., Okada, K., Ishikawa, T., Himeno, M. & Kato, K., Feb 14 1990, In : Biochemical and Biophysical Research Communications. 166, 3, p. 1176-1182 7 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Release of acid phosphatase from lysosomal membranes by cathepsin D

Tanaka, Y., Himeno, M. & Kato, K., Jan 1 1990, In : Journal of biochemistry. 108, 2, p. 287-291 5 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Saposins (sphingolipid activator proteins) in the twitcher mutant mouse

Shigematsu, H., Morimoto, S., Kishimoto, Y., Weiler, S., Tomich, J., Barranger, J., Shinohara, M., Yeager, A. M. & O'Brien, J. S., Nov 1990, In : Journal of Neurochemistry. 55, 5, p. 1659-62 4 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Transport of acid phosphatase to lysosomes does not involve passage through the cell surface

Tanaka, Y., Yano, S., Furuno, K., Ishikawa, T., Himeno, M. & Kato, K., Aug 16 1990, In : Biochemical and Biophysical Research Communications. 170, 3, p. 1067-1073 7 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)
1989

5′-Nucleotidase in Rat Liver Lysosomal Membranes is anchored via Glycosyl-Phosphatidylinositol

Tanaka, Y., Himeno, M., Taguchi, R., Ikezawa, H. & Kato, K., Jan 1 1989, In : Cell structure and function. 14, 5, p. 597-603 7 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Biochemical analysis of the movement of a major lysosomal membrane glycoprotein in the endocytic membrane system

Furuno, K., Yano, S., Akasaki, K., Tanaka, Y., Yamaguchi, Y., Tsuji, H., Himeno, M. & Kato, K., Jan 1 1989, In : Journal of biochemistry. 106, 4, p. 717-722 6 p.

Research output: Contribution to journalArticle

37 Citations (Scopus)

Brefeldin A inhibits the targeting of cathepsin D and cathepsin H to lysosomes in rat hepatocytes

Oda, K. & Nishimura, Y., Aug 30 1989, In : Biochemical and Biophysical Research Communications. 163, 1, p. 220-225 6 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Evidence that aspartic proteinase is involved in the proteolytic processing event of procathepsin L in lysosomes

Nishimura, Y., Kawabata, T., Furuno, K. & Kato, K., Jan 1 1989, In : Archives of Biochemistry and Biophysics. 271, 2, p. 400-406 7 p.

Research output: Contribution to journalArticle

58 Citations (Scopus)

Isolation and sequencing of a cDNA clone encoding 107 kDa sialoglycoprotein in rat liver lysosomal membranes

Himeno, M., Noguchi, Y., Sasaki, H., Tanaka, Y., Furuno, K., Kono, A., Sakaki, Y. & Kato, K., Feb 27 1989, In : FEBS Letters. 244, 2, p. 351-356 6 p.

Research output: Contribution to journalArticle

41 Citations (Scopus)

Isolation and sequencing of a cDNA clone encoding 96 kDa sialoglycoprotein in rat liver lysosomal membranes

Noguchi, Y., Himeno, M., Sasaki, H., Tanaka, Y., Kono, A., Sakaki, Y. & Kato, K., Nov 15 1989, In : Biochemical and Biophysical Research Communications. 164, 3, p. 1113-1120 8 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Magnesium and Ammonium-Potassium Lithospermates B, the Active Principles Having a Uremia-Preventive Effect from Salvia miltiorrhiza

Tanaka, T., Morimoto, S., Nonaka, G. I., Nishioka, I., Yokozawa, T., Chung, C., Oura, H. & Young, H., Jan 1 1989, In : Chemical and Pharmaceutical Bulletin. 37, 2, p. 340-344 5 p.

Research output: Contribution to journalArticle

115 Citations (Scopus)

Morphological localization of a major lysosomal membrane glycoprotein in the endocytic membrane system

Furuno, K., Ishikawa, T., Akasaki, K., Yano, S., Tanaka, Y., Yamaguchi, Y., Tsuji, H., Himeno, M. & Kato, K., Jan 1 1989, In : Journal of biochemistry. 106, 4, p. 708-716 9 p.

Research output: Contribution to journalArticle

46 Citations (Scopus)

Saposin A: second cerebrosidase activator protein

Morimoto, S., Martin, B. M., Yamamoto, Y., Kretz, K. A., O'Brien, J. S. & Kishimoto, Y., May 1989, In : Proceedings of the National Academy of Sciences of the United States of America. 86, 9, p. 3389-93 5 p.

Research output: Contribution to journalArticle

120 Citations (Scopus)

Species difference of UDP-glucuronyltransferase isozymes in liver microsomes

Oguri, K., Ishii, Y., Kojima, K. & Yoshimura, H., Jan 1 1989, In : journal of pharmacobio-dynamics. 12, 3, p. s-56

Research output: Contribution to journalMeeting Abstract

Synthesis and properties of a mercapto[15]annulenone: A 14π diatropic annulene triply characterised by a fast chemical exchange, tautomerisation, and cis-trans-isomerisation

Ogawa, H., Yoshikawa, M., Tanaka, H., Imoto, T., Miyamoto, I., Kato, H., Taniguchi, Y., Nogami, Y. & Koga, T., Jan 1 1989, In : Journal of the Chemical Society, Chemical Communications. 8, p. 505-507 3 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
1988

Biosynthesis and processing of lysosomal cathepsin L in primary cultures of rat hepatocytes

Nishimura, Y., Furuno, K. & Kato, K., May 15 1988, In : Archives of Biochemistry and Biophysics. 263, 1, p. 107-116 10 p.

Research output: Contribution to journalArticle

55 Citations (Scopus)

Biosynthesis of lysosomal cathepsins B and H in cultured rat hepatocytes

Nishimura, Y., Amano, J., Sato, H., Tsuji, H. & Kato, K., Apr 1988, In : Archives of Biochemistry and Biophysics. 262, 1, p. 159-170 12 p.

Research output: Contribution to journalArticle

45 Citations (Scopus)

Identification of latent procathepsin H in microsomal lumen: Characterization of proteolytic processing and enzyme activation

Nishimura, Y. & Kato, K., Feb 1 1988, In : Archives of Biochemistry and Biophysics. 260, 2, p. 712-718 7 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)

Identification of latent procathepsins B and L in microsomal lumen: Characterization of enzymatic activation and proteolytic processing in vitro

Nishimura, Y., Kawabata, T. & Kato, K., Feb 15 1988, In : Archives of Biochemistry and Biophysics. 261, 1, p. 64-71 8 p.

Research output: Contribution to journalArticle

148 Citations (Scopus)

Localization of cathepsin L in rat kidney revealed by immunoenzyme and immunogold techniques

Yokota, S., Nishimura, Y. & Kato, K., Jul 1 1988, In : Histochemistry. 90, 4, p. 277-283 7 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Prenylated flavan-3-ols and procyanidins from Illicium anisatum

Morimoto, S., Tanabe, H., Nonaka, G. I. & Nishioka, I., 1988, In : Phytochemistry. 27, 3, p. 907-910 4 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Saposin D: a sphingomyelinase activator

Morimoto, S., Martin, B. M., Kishimoto, Y. & O'Brien, J. S., Oct 14 1988, In : Biochemical and Biophysical Research Communications. 156, 1, p. 403-10 8 p.

Research output: Contribution to journalArticle

92 Citations (Scopus)

Structures of sugar chains of a p-nitrophenyl acetate-hydrolyzing esterase from the microsomes of rat liver

Natsuka, S., Himeno, M., Hase, S., Ito, H., Ueda, T., Kato, K. & Ikenaka, T., Jan 1 1988, In : Journal of biochemistry. 103, 6, p. 986-991 6 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)
5 Citations (Scopus)
17 Citations (Scopus)

Studies on the constituents of marine opisthobranchia, IV. Two new polyhalogenated monoterpenes from the sea hare Aplysia kurodai

Miyamoto, T., Higuchi, R., Marubayashi, N. & Komori, T., Jan 1 1988, In : Liebigs Annalen der Chemie. 1988, 12, p. 1191-1193 3 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)