Research Output

Cyclic di-GMP acts as a cell cycle oscillator to drive chromosome replication

Lori, C., Ozaki, S., Steiner, S., Böhm, R., Abel, S., Dubey, B. N., Schirmer, T., Hiller, S. & Jenal, U., Jul 9 2015, In : Nature. 523, 7559, p. 236-239 4 p.

Research output: Contribution to journalArticle

90 Citations (Scopus)

Curcumin anticipates the suppressed body weight gain with 2,3,7,8-tetrachlorodibenzo-p-dioxin in mice

Ishida, T., Taketoh, J., Nakatsune, E., Kan-o, S., Naito, E., Takeda, S., Mutoh, J., Ishii, Y. & Yamada, H., Oct 1 2004, In : Journal of Health Science. 50, 5, p. 474-482 9 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

C-Type Lectin Receptor DCAR Recognizes Mycobacterial Phosphatidyl-Inositol Mannosides to Promote a Th1 Response during Infection

Toyonaga, K., Torigoe, S., Motomura, Y., Kamichi, T., Hayashi, J. M., Morita, Y. S., Noguchi, N., Chuma, Y., Kiyohara, H., Matsuo, K., Tanaka, H., Nakagawa, Y., Sakuma, T., Ohmuraya, M., Yamamoto, T., Umemura, M., Matsuzaki, G., Yoshikai, Y., Yano, I., Miyamoto, T. & 1 others, Yamasaki, S., Dec 20 2016, In : Immunity. 45, 6, p. 1245-1257 13 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)

C-type Lectin Mincle Recognizes Glucosyl-diacylglycerol of Streptococcus pneumoniae and Plays a Protective Role in Pneumococcal Pneumonia

Behler-Janbeck, F., Takano, T., Maus, R., Stolper, J., Jonigk, D., Tort Tarrés, M., Fuehner, T., Prasse, A., Welte, T., Timmer, M. S. M., Stocker, B. L., Nakanishi, Y., Miyamoto, T., Yamasaki, S. & Maus, U. A., Dec 6 2016, In : PLoS pathogens. 12, 12, e1006038.

Research output: Contribution to journalArticle

25 Citations (Scopus)

C-terminal cysteine PEGylation of adalimumab fab with an engineered interchain SS bond

Nakamura, H., Anraku, M., Oda-Ueda, N., Ueda, T. & Ohkuri, T., Mar 1 2020, In : Biological and Pharmaceutical Bulletin. 43, 3, p. 418-423 6 p.

Research output: Contribution to journalArticle

Open Access

Crystal structures of the ribonuclease MC1 mutants N71T and N71S in complex with 5′-GMP: Structural basis for alterations in substrate specificity

Numata, T., Suzuki, A., Kakuta, Y., Kimura, K., Yao, M., Tanaka, I., Yoshida, Y., Ueda, T. & Kimura, M., May 13 2003, In : Biochemistry. 42, 18, p. 5270-5278 9 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Crystal structures of K33 mutant hen lysozymes with enhanced activities

Goto, T., Ohkuri, T., Shioi, S., Abe, Y., Imoto, T. & Ueda, T., Nov 1 2008, In : Journal of biochemistry. 144, 5, p. 619-623 5 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Crystal structure of the human monocyte-activating receptor, "Group 2" leukocyte Ig-like receptor A5 (LILRA5/LIR9/ILT11)

Shiroishi, M., Kajikawa, M., Kuroki, K., Ose, T., Kohda, D. & Maenaka, K., Jul 14 2006, In : Journal of Biological Chemistry. 281, 28, p. 19536-19544 9 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Crystal structure of the enzyme CapF of Staphyloccus aureus reveals a unique architecture composed of two functional domains

Miyafusa, T., Caaveiro, J. M. M., Tanaka, Y. & Tsumoto, K., 2012, In : Biochemical Journal. 443, p. 671-680 10 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Crystal structure of the complex of the interaction domains of Escherichia coli DnaB helicase and DnaC helicase loader: Structural basis implying a distortion-accumulation mechanism for the DnaB ring opening caused by DnaC binding

Nagata, K., Okada, A., Ohtsuka, J., Ohkuri, T., Akama, Y., Sakiyama, Y., Miyazaki, E., Horita, S., Katayama, T., Ueda, T. & Tanokura, M., Jan 1 2020, In : Journal of biochemistry. 167, 1, p. 1-14 14 p.

Research output: Contribution to journalArticle

Open Access

Crystal structure of the anion exchanger domain of human erythrocyte band 3

Arakawa, T., Kobayashi-Yurugi, T., Alguel, Y., Iwanari, H., Hatae, H., Iwata, M., Abe, Y., Hino, T., Ikeda-Suno, C., Kuma, H., Kang, D., Murata, T., Hamakubo, T., Cameron, A. D., Kobayashi, T., Hamasaki, N. & Iwata, S., Nov 6 2015, In : Science. 350, 6261, p. 680-684 5 p.

Research output: Contribution to journalArticle

91 Citations (Scopus)
59 Citations (Scopus)
64 Citations (Scopus)

Crystal structure of a biologically functional form of PriB from Escherichia coli reveals a potential single-stranded DNA-binding site

Shioi, S., Ose, T., Maenaka, K., Shiroishi, M., Abe, Y., Kohda, D., Katayama, T. & Ueda, T., Jan 28 2005, In : Biochemical and Biophysical Research Communications. 326, 4, p. 766-776 11 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Crystal structure-based virtual screening for fragment-like ligands of the human histamine H 1 receptor

De Graaf, C., Kooistra, A. J., Vischer, H. F., Katritch, V., Kuijer, M., Shiroishi, M., Iwata, S., Shimamura, T., Stevens, R. C., De Esch, I. J. P. & Leurs, R., Dec 8 2011, In : Journal of Medicinal Chemistry. 54, 23, p. 8195-8206 12 p.

Research output: Contribution to journalArticle

162 Citations (Scopus)

Crystal structure and calcium-induced conformational changes of diacylglycerol kinase α EF-hand domains

Takahashi, D., Suzuki, K., Sakamoto, T., Iwamoto, T., Murata, T. & Sakane, F., Apr 2019, In : Protein Science. 28, 4, p. 694-706 13 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Crystallization of Δ1-tetrahydrocannabinolic acid (THCA) synthase from Cannabis sativa

Shoyama, Y., Takeuchi, A., Taura, F., Tamada, T., Adachi, M., Kuroki, R., Shoyama, Y. & Morimoto, S., Aug 1 2005, In : Acta Crystallographica Section F: Structural Biology and Crystallization Communications. 61, 8, p. 799-801 3 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Crystallization of Human Erythrocyte Band 3, the anion exchanger, at the International Space Station “KIBO”

Hatae, H., Inaka, K., Okamura, R., Furubayashi, N., Kamo, M., Kobayashi, T., Abe, Y., Iwata, S. & Hamasaki, N., Oct 15 2018, In : Analytical Biochemistry. 559, p. 91-93 3 p.

Research output: Contribution to journalArticle

Crystallization and preliminary X-ray diffraction studies of polyketide synthase-1 (PKS-1) from Cannabis sativa

Taguchi, C., Taura, F., Tamada, T., Shoyama, Y., Shoyama, Y., Tanaka, H., Kuroki, R. & Morimoto, S., Mar 13 2008, In : Acta Crystallographica Section F: Structural Biology and Crystallization Communications. 64, 3, p. 217-220 4 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)
1 Citation (Scopus)

Cryo-EM structure of a helicase loading intermediate containing ORC-Cdc6-Cdt1-MCM2-7 bound to DNA

Sun, J., Evrin, C., Samel, S. A., Fernández-Cid, A., Riera, A., Kawakami, H., Stillman, B., Speck, C. & Li, H., Aug 1 2013, In : Nature Structural and Molecular Biology. 20, 8, p. 944-951 8 p.

Research output: Contribution to journalArticle

96 Citations (Scopus)

Cross-reactivity of various tetrahydrocannabinol metabolites with a monoclonal antibody against tetrahydrocannabinolic acid

Watanabe, K., Matsuda, M., Tateoka, Y., Kimura, T., Matsunaga, T., Tanaka, H., Shoyama, Y. & Yamamoto, I., Jan 1 2000, In : Journal of Health Science. 46, 4, p. 310-313 4 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Crocin suppresses tumor necrosis factor-α-induced cell death of neuronally differentiated PC-12 cells

Soeda, S., Ochiai, T., Paopong, L., Tanaka, H., Shoyama, Y. & Shimeno, H., Nov 2 2001, In : Life Sciences. 69, 24, p. 2887-2898 12 p.

Research output: Contribution to journalArticle

126 Citations (Scopus)

Crocin promotes non-rapid eye movement sleep in mice

Masaki, M., Aritake, K., Tanaka, H., Shoyama, Y., Huang, Z. L. & Urade, Y., Feb 1 2012, In : Molecular Nutrition and Food Research. 56, 2, p. 304-308 5 p.

Research output: Contribution to journalArticle

33 Citations (Scopus)

Crocin prevents the death of rat pheochromyctoma (PC-12) cells by its antioxidant effects stronger than those of α-tocopherol

Ochiai, T., Ohno, S., Soeda, S., Tanaka, H., Shoyama, Y. & Shimeno, H., May 13 2004, In : Neuroscience Letters. 362, 1, p. 61-64 4 p.

Research output: Contribution to journalArticle

186 Citations (Scopus)

Crocin prevents the death of PC-12 cells through sphingomyelinase-ceramide signaling by increasing glutathione synthesis

Ochiai, T., Soeda, S., Ohno, S., Tanaka, H., Shoyama, Y. & Shimeno, H., Apr 2004, In : Neurochemistry International. 44, 5, p. 321-330 10 p.

Research output: Contribution to journalArticle

95 Citations (Scopus)

Crocin and crocetin derivatives inhibit skin tumour promotion in mice

Konoshima, T., Takasaki, M., Tokuda, H., Morimoto, S., Tanaka, H., Kawata, E., Xuan, L. J., Saito, H., Sugiura, M., Molnar, J. & Shoyama, Y., Sep 1 1998, In : Phytotherapy Research. 12, 6, p. 400-404 5 p.

Research output: Contribution to journalArticle

61 Citations (Scopus)

Creating a unique environment for selecting reactive enzymes with DNA: 'Sticky' binding of oligocation-grafted polymers to DNA

Tanaka, H., Mori, T., Niidome, T. & Katayama, Y., Feb 1 2012, In : Bioorganic and Medicinal Chemistry. 20, 3, p. 1346-1353 8 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Covalent binding of nitroso-sulfonamides to glutathione S-transferase in guinea pigs with delayed type hypersensitivity

Eyanagi, R., Toda, A., Imoto, M., Uchiyama, H., Ishii, Y., Kuroki, H., Kuramoto, Y., Soeda, S. & Shimeno, H., Apr 1 2012, In : International Immunopharmacology. 12, 4, p. 694-700 7 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Costunolide, a sesquiterpene lactone from Saussurea lappa, inhibits the VEGFR KDR/Flk-1 signaling pathway

Jeong, S. J., Itokawa, T., Shibuya, M., Kuwano, M., Ono, M., Higuchi, R. & Miyamoto, T., Dec 10 2002, In : Cancer Letters. 187, 1-2, p. 129-133 5 p.

Research output: Contribution to journalArticle

65 Citations (Scopus)

Correlation between the differences in the free energy change and conformational energy in the folded state of hen lysozymes with gly-pro and pro-gly sequences introduced to the same site

Motoshima, H., Ueda, T., Hashimoto, Y., Tsutsumi, M. & Imoto, T., Dec 1995, In : Journal of biochemistry. 118, 6, p. 1138-1144 7 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)
2 Citations (Scopus)

Cooperative working of bacterial chromosome replication proteins generated by a reconstituted protein expression system

Fujiwara, K., Katayama, T. & Nomura, S. I. M., Aug 2013, In : Nucleic acids research. 41, 14, p. 7176-7183 8 p.

Research output: Contribution to journalArticle

32 Citations (Scopus)

Cooperative research and educational center for breeding and standardization of medicinal plants and drug development between Japan and China

Tanaka, H., Apr 1 2009, In : Yakugaku Zasshi. 129, 4, p. 393-400 8 p.

Research output: Contribution to journalReview article

Cooperative DnaA binding to the negatively supercoiled datA locus stimulates DnaA-ATP hydrolysis

Kasho, K., Tanaka, H., Sakai, R. & Katayama, T., Jan 27 2017, In : Journal of Biological Chemistry. 292, 4, p. 1251-1266 16 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Conversion of γ-hydroxybutyric acid to a fluorescent derivative: A method for screening

Matsuda, K., Asakawa, N., Iwanaga, M., Gohda, A., Fukushima, S., Ishii, Y. & Yamada, H., Jul 1 2006, In : Forensic Toxicology. 24, 1, p. 41-47 7 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Contribution of conformational stability of hen lysozyme to induction of type 2 T-helper immune responses

So, T., Ito, H. O., Hirata, M., Ueda, T. & Imoto, T., Nov 26 2001, In : Immunology. 104, 3, p. 259-268 10 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)

Contribution of asparagine residues to the stabilization of a proteinaceous antigen-antibody complex, HyHEL-10-Hen egg white lysozyme

Yokota, A., Tsumoto, K., Shiroishi, M., Nakanishi, T., Kondo, H. & Kumagai, I., Mar 5 2010, In : Journal of Biological Chemistry. 285, 10, p. 7686-7696 11 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Continuous flow immunosensor for highly selective and real-time detection of sub-ppb levels of 2-hydroxybiphenyl by using surface plasmon resonance imaging

Gobi, K. V., Tanaka, H., Shoyama, Y. & Miura, N., Sep 15 2004, In : Biosensors and Bioelectronics. 20, 2, p. 350-357 8 p.

Research output: Contribution to journalArticle

46 Citations (Scopus)

Construction of the single-chain Fv from 196-14 antibody toward ovarian cancer-associated antigen CA125

Hashimoto, Y., Tanigawa, K., Nakashima, M., Sonoda, K., Ueda, T., Watanabe, T. & Imoto, T., Jan 1 1999, In : Biological and Pharmaceutical Bulletin. 22, 10, p. 1068-1072 5 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Construction of a yeast expression system with positive selection for gene insertion in the absence of a specific phenotype

Hashimoto, Y., Miki, T., Mukae, M., Ueda, T. & Imoto, T., Jan 30 1998, In : Gene. 207, 2, p. 167-170 4 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Construction and expression of specificity-improved single-chain variable fragments against the bioactive naphthoquinone, plumbagin

Sakamoto, S., Taura, F., Putalun, W., Pongkitwitoon, B., Tsuchihashi, R., Morimoto, S., Kinjo, J., Shoyama, Y. & Tanaka, H., Mar 1 2009, In : Biological and Pharmaceutical Bulletin. 32, 3, p. 434-439 6 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Construction and expression of a single chain Fv fragment against pharmacologically active paeoniflorin in Escherichia coli, and its potential use in an enzyme-linked immunosorbent assay

Lu, Z., Masaki, T., Shoyama, Y. & Tanaka, H., Feb 1 2006, In : Planta medica. 72, 2, p. 151-155 5 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Construction, expression, and characterization of a single-chain variable fragment antibody against 2,4-dichlorophenoxyacetic acid in the hemolymph of silkworm larvae

Sakamoto, S., Pongkitwitoon, B., Nakamura, S., Sasaki-Tabata, K., Tanizaki, Y., Maenaka, K., Tanaka, H. & Morimoto, S., Jul 1 2011, In : Applied Biochemistry and Biotechnology. 164, 6, p. 715-728 14 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Constituents of Holothuroideae, V. Isolation and Structure of Cerebrosides from the Sea Cucumber Pentacta australis

Higuchi, R., Inagaki, M., Togawa, K., Miyamoto, T. & Komori, T., Jan 1 1994, In : Liebigs Annalen der Chemie. 1994, 7, p. 653-658 6 p.

Research output: Contribution to journalArticle

60 Citations (Scopus)

Constituents of holothuroideae, IV. Isolation and structure of three new cerebrosides, CE‐2b, CE‐2c and CE‐2d, from the sea cucumber Cucumaria echinata

Higuchi, R., Inagaki, M., Togawa, K., Miyamoto, T. & Komori, T., Jan 1 1994, In : Liebigs Annalen der Chemie. 1994, 1, p. 79-81 3 p.

Research output: Contribution to journalArticle

32 Citations (Scopus)

Constituents of holothuroidea.9. Isolation and structure of a new ganglioside molecular species from the sea cucumber Holothuria pervicax

Yamada, K., Harada, Y., Miyamoto, T., Isobi, R. & Higuchi, R., Jan 2000, In : Chemical and Pharmaceutical Bulletin. 48, 1, p. 157-159 3 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)

Constituents of holothuroidea. 10. Isolation and structure of a biologically active ganglioside molecular species from the sea cucumber Holothuria leucospilota

Yamada, K., Matsubara, R., Kaneko, M., Miyamoto, T. & Higuchi, R., May 5 2001, In : Chemical and Pharmaceutical Bulletin. 49, 4, p. 447-452 6 p.

Research output: Contribution to journalArticle

55 Citations (Scopus)

Constituents of holothuroidea, II. Six newly identified biologically active triterpenoid glycoside sulfates from the sea cucumber Cucumaria echinata

Miyamoto, T., Togawa, K., Higuchi, R., Komori, T. & Sasaki, T., Jan 1 1990, In : Liebigs Annalen der Chemie. 1990, 5, p. 453-460 8 p.

Research output: Contribution to journalArticle

44 Citations (Scopus)

Constituents of holothuroidea, I. Isolation and structures of three triterpenoid aglycones, cucumechinol A, B, and C, from the sea cucumber Cucumaria echinata

Miyamoto, T., Togawa, K., Higuchi, R. & Komori, T., Jan 1 1990, In : Liebigs Annalen der Chemie. 1990, 1, p. 39-42 4 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)