Research Output

1989

Magnesium and Ammonium-Potassium Lithospermates B, the Active Principles Having a Uremia-Preventive Effect from Salvia miltiorrhiza

Tanaka, T., Morimoto, S., Nonaka, G. I., Nishioka, I., Yokozawa, T., Chung, C., Oura, H. & Young, H., Jan 1 1989, In : Chemical and Pharmaceutical Bulletin. 37, 2, p. 340-344 5 p.

Research output: Contribution to journalArticle

115 Citations (Scopus)

Morphological localization of a major lysosomal membrane glycoprotein in the endocytic membrane system

Furuno, K., Ishikawa, T., Akasaki, K., Yano, S., Tanaka, Y., Yamaguchi, Y., Tsuji, H., Himeno, M. & Kato, K., Oct 1989, In : Journal of biochemistry. 106, 4, p. 708-716 9 p.

Research output: Contribution to journalArticle

46 Citations (Scopus)

Saposin A: second cerebrosidase activator protein

Morimoto, S., Martin, B. M., Yamamoto, Y., Kretz, K. A., O'Brien, J. S. & Kishimoto, Y., May 1989, In : Proceedings of the National Academy of Sciences of the United States of America. 86, 9, p. 3389-93 5 p.

Research output: Contribution to journalArticle

120 Citations (Scopus)

Species difference of UDP-glucuronyltransferase isozymes in liver microsomes

Oguri, K., Ishii, Y., Kojima, K. & Yoshimura, H., Jan 1 1989, In : journal of pharmacobio-dynamics. 12, 3, p. s-56

Research output: Contribution to journalMeeting Abstract

Synthesis and properties of a mercapto[15]annulenone: A 14π diatropic annulene triply characterised by a fast chemical exchange, tautomerisation, and cis-trans-isomerisation

Ogawa, H., Yoshikawa, M., Tanaka, H., Imoto, T., Miyamoto, I., Kato, H., Taniguchi, Y., Nogami, Y. & Koga, T., Jan 1 1989, In : Journal of the Chemical Society, Chemical Communications. 8, p. 505-507 3 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
1990

Augmented excretion of procathepsin L of a fos-transferred highly metastatic rat cell line

Taniguchi, S., Nishimura, Y., Takahashi, T., Baba, T. & Kato, K., Apr 30 1990, In : Biochemical and Biophysical Research Communications. 168, 2, p. 520-526 7 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

Biosythesis processing, and intracellular transport of lysosomal acid phosphatase in rat hepatocytes

Tanaka, Y., Harada, R., Himeno, M. & Kato, K., Aug 1990, In : Journal of biochemistry. 108, 2, p. 278-286 9 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

Characterization of a mutation in a family with saposin B deficiency: a glycosylation site defect

Kretz, K. A., Carson, G. S., Morimoto, S., Kishimoto, Y., Fluharty, A. L. & O'Brien, J. S., Apr 1990, In : Proceedings of the National Academy of Sciences of the United States of America. 87, 7, p. 2541-4 4 p.

Research output: Contribution to journalArticle

103 Citations (Scopus)

Comparative study on specificities of rat cathepsin L and papain: Amino acid differences at substrate-binding sites are involved in their specificities

Koga, H., Yamada, H., Nishimura, Y., Kato, K. & Imoto, T., Jan 1 1990, In : Journal of Biochemistry. 108, 6, p. 976-982 7 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

Constituents of holothuroidea, I. Isolation and structures of three triterpenoid aglycones, cucumechinol A, B, and C, from the sea cucumber Cucumaria echinata

Miyamoto, T., Togawa, K., Higuchi, R. & Komori, T., Jan 1 1990, In : Liebigs Annalen der Chemie. 1990, 1, p. 39-42 4 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Constituents of holothuroidea, II. Six newly identified biologically active triterpenoid glycoside sulfates from the sea cucumber Cucumaria echinata

Miyamoto, T., Togawa, K., Higuchi, R., Komori, T. & Sasaki, T., Jan 1 1990, In : Liebigs Annalen der Chemie. 1990, 5, p. 453-460 8 p.

Research output: Contribution to journalArticle

45 Citations (Scopus)

Determination of saposin proteins (sphingolipid activator proteins) in human tissues

Morimoto, S., Yamamoto, Y., O'Brien, J. S. & Kishimoto, Y., Nov 1 1990, In : Analytical Biochemistry. 190, 2, p. 154-7 4 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)
58 Citations (Scopus)

Effect of chemical modifications of tryptophan residues on the folding of reduced hen egg-white lysozyme

Ueda, T., Yamada, H., Aoki, H. & Imoto, T., Jan 1 1990, In : Journal of Biochemistry. 108, 5, p. 886-892 7 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Immunocytochemical study of the surrounding envelope of autophagic vacuoles in cultured rat hepatocytes

Furuno, K., Ishikawa, T., Akasaki, K., Lee, S., Nishimura, Y., Tsuji, H., Himeno, M. & Kato, K., Aug 1990, In : Experimental Cell Research. 189, 2, p. 261-268 8 p.

Research output: Contribution to journalArticle

45 Citations (Scopus)

Immunoenzyme localization of cathepsins in the Golgi region of rat hepatocytes and renal tubule cells

Yokota, S., Nishimura, Y., Kawabata, T. & Kato, K., Nov 1 1990, In : Histochemistry. 94, 6, p. 629-635 7 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Inhibition of intracellular sorting and processing of lysosomal cathepsins H and L at reduced temperature in primary cultures of rat hepatocytes

Nishimura, Y., Kawabata, T., Yano, S. & Kato, K., Jan 1 1990, In : Archives of Biochemistry and Biophysics. 283, 2, p. 458-463 6 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)

Interaction of saposins, acidic lipids, and glucosylceramidase

Morimoto, S., Kishimoto, Y., Tomich, J., Weiler, S., Ohashi, T., Barranger, J. A., Kretz, K. A. & O'Brien, J. S., Feb 5 1990, In : Journal of Biological Chemistry. 265, 4, p. 1933-7 5 p.

Research output: Contribution to journalArticle

60 Citations (Scopus)

Lysosomal acid phosphatase is transported via endosomes to lysosomes

Tanaka, Y., Yano, S., Okada, K., Ishikawa, T., Himeno, M. & Kato, K., Feb 14 1990, In : Biochemical and Biophysical Research Communications. 166, 3, p. 1176-1182 7 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Release of acid phosphatase from lysosomal membranes by cathepsin D

Tanaka, Y., Himeno, M. & Kato, K., Aug 1990, In : Journal of biochemistry. 108, 2, p. 287-291 5 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Saposins (sphingolipid activator proteins) in the twitcher mutant mouse

Shigematsu, H., Morimoto, S., Kishimoto, Y., Weiler, S., Tomich, J., Barranger, J., Shinohara, M., Yeager, A. M. & O'Brien, J. S., Nov 1990, In : Journal of Neurochemistry. 55, 5, p. 1659-62 4 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Transport of acid phosphatase to lysosomes does not involve passage through the cell surface

Tanaka, Y., Yano, S., Furuno, K., Ishikawa, T., Himeno, M. & Kato, K., Aug 16 1990, In : Biochemical and Biophysical Research Communications. 170, 3, p. 1067-1073 7 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)
1991

1H-NMR study of the intramolecular interaction of a substrate analogue covalently attached to aspartic acid-101 in lysozyme

Ueda, T., Isakari, Y., Aoki, H., Yasukochi, T., Masutomo, S. I., Kawano, K., Terada, Y., Yamada, H. & Imoto, T., Jan 1 1991, In : Journal of Biochemistry. 109, 5, p. 690-698 9 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Bafilomycin A1 inhibits the targeting of lysosomal acid hydrolases in cultured hepatocytes

Oda, K., Nishimura, Y., Ikehara, Y. & Kato, K., Jul 15 1991, In : Biochemical and Biophysical Research Communications. 178, 1, p. 369-377 9 p.

Research output: Contribution to journalArticle

43 Citations (Scopus)

Isolation and sequencing of a cDNA clone encoding rat liver lysosomal cathepsin D and the structure of three forms of mature enzymes

Fujita, H., Tanaka, Y., Noguchi, Y., Kono, A., Himeno, M. & Kato, K., Aug 30 1991, In : Biochemical and Biophysical Research Communications. 179, 1, p. 190-196 7 p.

Research output: Contribution to journalArticle

35 Citations (Scopus)

Mechanisms of a conversion from membrane associated lysosomal acid phosphatase to content forms

Himeno, M., Nakamura, K., Tanaka, Y., Yamada, H., Imoto, T. & Kato, K., Nov 14 1991, In : Biochemical and Biophysical Research Communications. 180, 3, p. 1483-1489 7 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Multiple proteolytic action of rat liver cathepsin B: Specificities and pH-dependences of the endo- and exopeptidase activities

Koga, H., Yamada, H., Nishimura, Y., Kato, K. & Imoto, T., Jan 1 1991, In : Journal of Biochemistry. 110, 2, p. 179-188 10 p.

Research output: Contribution to journalArticle

36 Citations (Scopus)

Preparation and properties of a lysozyme derivative in which two domains are cross-linked intramolecularly between trp62 and asp101

Ueda, T., Yamada, H., Sakamoto, N., Abe, Y., Kawano, K., Terada, Y. & Imoto, T., Jan 1 1991, In : Journal of biochemistry. 110, 5, p. 719-725 7 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Rat cathepsin H-catalyzed transacylation: Comparisons of the mechanism and the specificity with papain-superfamily proteases

Koga, H., Mori, N., Yamada, H., Nishimura, Y., Tokuda, K., Kato, K. & Imoto, T., Jan 1 1991, In : Journal of Biochemistry. 110, 6, p. 939-944 6 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)
1992

Endo- and Aminopeptidase Activities of Rat Cathepsin H

Koga, H., Mori, N., Yamada, H., Nishimura, Y., Tokuda, K., Kato, K. & Taiji, T., Jan 1 1992, In : Chemical and Pharmaceutical Bulletin. 40, 4, p. 965-970 6 p.

Research output: Contribution to journalArticle

38 Citations (Scopus)

Expression of mouse cathepsin L cDNA in Saccharomyces cerevisiae: Evidence that cathepsin L is sorted for targeting to yeast vacuole

Nishimura, Y. & Kato, K., Nov 1 1992, In : Archives of Biochemistry and Biophysics. 298, 2, p. 318-324 7 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Flavan-3-ol gallates and proanthocyanidins from Pithecellobium lobatum

Min-Won, L., Morimoto, S., Nonaka, G. I. & Nishioka, I., Jan 1 1992, In : Phytochemistry. 31, 6, p. 2117-2120 4 p.

Research output: Contribution to journalArticle

50 Citations (Scopus)

Isolation and sequencing of a cDNA clone encoding the 85 kDa human lysosomal sialoglycoprotein (hLGP85) in human metastatic pancreas islet tumor cells

Fujita, H., Takata, Y., Kono, A., Tanaka, Y., Takahashi, T., Himeno, M. & Kato, K., Apr 30 1992, In : Biochemical and Biophysical Research Communications. 184, 2, p. 604-611 8 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

Possible involvement of cathepsin L in processing of rat liver hexokinase to eliminate mitochondria-binding ability

Okazaki, H., Tanl, C., Ando, M., Ishii, K., Ishibashi, S., Nishimura, Y. & Kato, K., Jan 1 1992, In : Journal of biochemistry. 112, 3, p. 409-413 5 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Structures of four new triterpenoid oligoglycosides: DS-penaustrosides A, B, C, and D from the sea cucumber pentacta australis

Miyamoto, T., Togawa, K., Higuchi, R., Komori, T. & Sasaki, T., Jul 1 1992, In : Journal of Natural Products. 55, 7, p. 940-946 7 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)

Three new cytotoxic sesterterpenoids, inorolide A, B, and C from the nudibranch Chromodoris inornata

Miyamoto, T., Sakamoto, K., Amano, H., Higuchi, R., Komori, T. & Sasaki, T., Sep 22 1992, In : Tetrahedron Letters. 33, 39, p. 5811-5814 4 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)
1993

Cannabis, 21. Biotransformation of cannabinol to its glycosides by in vitro plant tissue

Tanaka, H., Morimoto, S. & Shoyama, Y., Dec 1993, In : Journal of Natural Products. 56, 12, p. 2068-2072 5 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Expression and Localization of a Major Lysosomal Membrane Sialoglycoprotein (LGP107) in Plasma Membranes of Rat Osteoblasts and Osteocytes

Akamine, A., Klmura, R., Maeda, K., Tsukuba, T., Yamamoto, K., Tanaka, Y. & Kato, K., 1993, In : Archives of Histology and Cytology. 56, 5, p. 525-532 8 p.

Research output: Contribution to journalArticle

Immunohistochemical localization of cathepsins B, D and L in the rat osteoclast

Goto, T., Tsukuba, T., Kiyoshima, T., Nishimura, Y., Kato, K., Yamamoto, K. & Tanaka, T., May 1 1993, In : Histochemistry. 99, 5, p. 411-414 4 p.

Research output: Contribution to journalArticle

68 Citations (Scopus)

Increased synthesis and specific localization of a major lysosomal membrane sialoglycoprotein (LGP107) at the ruffled border membrane of active osteoclasts

Akamine, A., Tsukuba, T., Kimura, R., Maeda, K., Tanaka, Y., Kato, K. & Yamamoto, K., Aug 1 1993, In : Histochemistry. 100, 2, p. 101-108 8 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Inducing ability of co-planar PCBs toward bilirubin UDP-glucuronyltransferase of liver microsomes: the remarkable difference between guinea pigs and rats

Oguri, K., Koga, Y., Tsuda, M., Ariyoshi, N., Ishii, Y., Yamada, H. & Yoshimura, H., Jan 1 1993, In : Fukuoka igaku zasshi = Hukuoka acta medica. 84, 5, p. 175-180 6 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Induction of bilirubin UDP-glucuronyltransferase and P-450 4A subfamily in guinea pigs by treatment with coplanar PCB

Koga, Y., Tsuda, M., Ariyoshi, N., Ishii, Y., Yamada, H., Oguri, K., Yoshimura, H. & Funae, Y., 1993, In : Japanese Journal of Toxicology and Environmental Health. 39, 1

Research output: Contribution to journalArticle

Modification of the gluconeogenesis is not involved in the co-planar PCB toxicity in highly sensitive guinea pigs

Oguri, K., Hatsumura, M., Ishii, Y., Koga, Y., Ariyoshi, N. & Yoshimura, H., Dec 1993, In : Chemosphere. 27, 11, p. 2295-2303 9 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Picrotoxin as a potent inducer of rat hepatic cytochrome P450, CYP2b1 and CYP2b2

Yamada, H., Fujisaki, H., Kaneko, H., Ishii, Y., Hamaguchi, T. & Oguri, K., May 5 1993, In : Biochemical Pharmacology. 45, 9, p. 1783-1789 7 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

Purification and Characterization of a Morphine UDP-Glucuronyltransferase Isoform from Untreated Rat Liver

Ishii, Y., Oguri, K. & Yoshimura, H., Jan 1 1993, In : Biological and Pharmaceutical Bulletin. 16, 8, p. 754-758 5 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Purification and processing of rat liver procathepsin B

Kawabata, T., Nishimura, Y., Higaki, M. & Kato, K., Jan 1 1993, In : Journal of Biochemistry. 113, 3, p. 389-394 6 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

Stabilization of lysozyme by the introduction of gly-pro sequence

Ueda, T., Tamura, T., Maeda, Y., Hashimoto, Y., Miki, T., Yamada, H. & Imoto, T., Feb 1 1993, In : Protein Engineering, Design and Selection. 6, 2, p. 183-187 5 p.

Research output: Contribution to journalArticle

35 Citations (Scopus)

The primary structures and properties of non‐stomach lysozymes of sheep and cow, and implication for functional divergence of lysozyme

ITO, Y., YAMADA, H., NAKAMURA, M., YOSHIKAWA, A., Ueda, T. & IMOTO, T., Jan 1 1993, In : European Journal of Biochemistry. 213, 2, p. 649-658 10 p.

Research output: Contribution to journalArticle

36 Citations (Scopus)
14 Citations (Scopus)
1994

Bioactive terpenoids from Octocorallia, I. Bioactive diterpenoids: Litophynols A and B from the mucus of the soft coral Litophyton sp.

Miyamoto, T., Yamada, K., Ikeda, N., Komori, T. & Higuchi, R., Sep 1 1994, In : Journal of Natural Products. 57, 9, p. 1212-1219 8 p.

Research output: Contribution to journalArticle

48 Citations (Scopus)