Research Output 1976 2020

2001
16 Citations (Scopus)

Three new acylated triterpene saponins from Acanthophyllum squarrosum

Gaidi, G., Miyamoto, T., Rustaiyan, A. & Lacaille-Dubois, M. A., Aug 20 2001, In : Journal of Natural Products. 64, 7, p. 920-924 5 p.

Research output: Contribution to journalArticle

Triterpenes
Saponins
Nuclear magnetic resonance
gypsogenin
quillaic acid
23 Citations (Scopus)

Tolerance of point substitution of methionine for isoleucine in hen egg white lysozyme

Ohmura, T., Ueda, T., Hashimoto, Y. & Imoto, T., Aug 29 2001, In : Protein Engineering. 14, 6, p. 421-425 5 p.

Research output: Contribution to journalArticle

Egg White
Isoleucine
Muramidase
Methionine
Substitution reactions
1 Citation (Scopus)

Western blotting of glycyrrhetinic acid glucuronides using anti-glycyrrhizin monoclonal antibody

Shan, S. J., Tanaka, H., Hayashi, J. & Shoyama, Y., Jul 26 2001, In : Journal of Liquid Chromatography and Related Technologies. 24, 10, p. 1491-1499 9 p.

Research output: Contribution to journalArticle

Glycyrrhetinic Acid
Glycyrrhizic Acid
Glucuronides
Western Blotting
Monoclonal Antibodies
2000

181 IL-13の遺伝的多型と気管支喘息との相関

有馬和彦, 白川太郎, Klaus, A. D., 阿部義人, 山下哲次, 榎本雅夫, 嶽良博, 佐々木聖, 赤岩美奈, 于彬, 濱崎直孝, Julian, M. H. & 出原賢治, 2000, In : Japanese Journal of Allergology. 49, 9, p. 938

Research output: Contribution to journalArticle

606 Citations (Scopus)

Accumulation of autophagic vacuoles and cardiomyopathy LAMP-2-deficient mice

Tanaka, Y., Guhde, G., Suter, A., Eskelinen, E. L., Hartmann, D., Lüllmann-Rauch, R., Janssen, P. M. L., Blanz, J., Von Figura, K. & Saftig, P., Aug 24 2000, In : Nature. 406, 6798, p. 902-906 5 p.

Research output: Contribution to journalArticle

Lysosome-Associated Membrane Glycoproteins
Vacuoles
Cardiomyopathies
Protein Deficiency
Glycogen Storage Disease Type IIb
17 Citations (Scopus)

Analysis of the internal motion of free and ligand-bound human lysozyme by use of 15N NMR relaxation measurement: A comparison with those of hen lysozyme

Mine, S., Ueda, T., Hashimoto, Y. & Imoto, T., Jan 1 2000, In : Protein Science. 9, 9, p. 1669-1684 16 p.

Research output: Contribution to journalArticle

Muramidase
Nuclear magnetic resonance
Ligands
Amino Acid Sequence
Amino Acids

An evaluation of some model systems commonly used in the study of the sea anemone toxin equinatoxin II with membranes

Caaveiro, J. M. M., Gutiérrez-Aguirre, I., Tribout, M., Paredes, S. & González-Mañas, J. M., 2000, In : ACTA BIOLOGICA SLOVENICA. 43, 1-2, p. 93-97 5 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)

Applications of ELISA, Western blotting and immunoaffinity concentration for survey of ginsenosides in crude drugs of Panax species and traditional Chinese herbal medicines

Fukuda, N., Tanaka, H. & Shoyama, Y., Sep 13 2000, In : Analyst. 125, 8, p. 1425-1429 5 p.

Research output: Contribution to journalArticle

Ginsenosides
Column chromatography
Panax
Monoclonal antibodies
Herbal Medicine
25 Citations (Scopus)

Biologically active glycosides from asteroidea, 40 two new gangliosides, acanthagangliosides I and J from the starfish Acanthaster planci

Miyamoto, T., Yamamoto, A., Wakabayashi, M., Nagaregawa, Y., Inagaki, M., Higuchi, R., Iha, M. & Teruya, K., Jun 1 2000, In : European Journal of Organic Chemistry. 12, p. 2295-2301 7 p.

Research output: Contribution to journalArticle

glucosides
Gangliosides
Glycosides
hydrolysis
Enzymatic hydrolysis
6 Citations (Scopus)

Characterization of microsomal alcohol oxygenase catalyzing the oxidation of 7-hydroxy-Δ8-tetrahydrocannabinol to 7-oxo-Δ8- tetrahydrocannabinol in rat liver

Matsunaga, T., Shibayama, K., Higuchi, S., Tanaka, H., Watanabe, K. & Yamamoto, I., Jan 2000, In : Biological and Pharmaceutical Bulletin. 23, 1, p. 43-46 4 p.

Research output: Contribution to journalArticle

Oxygenases
Dronabinol
Alcohols
Liver
Microsomes
49 Citations (Scopus)

Characterization of the N-oligosaccharides attached to the atypical Asn- X-Cys sequence of recombinant human epidermal growth factor receptor

Sato, C., Kim, J. H., Abe, Y., Saito, K., Yokoyama, S. & Kohda, D., Jan 1 2000, In : Journal of biochemistry. 127, 1, p. 65-72 8 p.

Research output: Contribution to journalArticle

Glycosylation
Oligosaccharides
Epidermal Growth Factor Receptor
CHO Cells
X ray crystallography
27 Citations (Scopus)

Constituents of holothuroidea.9. Isolation and structure of a new ganglioside molecular species from the sea cucumber Holothuria pervicax

Yamada, K., Harada, Y., Miyamoto, T., Isobi, R. & Higuchi, R., Jan 2000, In : Chemical and Pharmaceutical Bulletin. 48, 1, p. 157-159 3 p.

Research output: Contribution to journalArticle

Holothuria
Sea Cucumbers
Gangliosides
PC12 Cells
Chloroform
7 Citations (Scopus)

Cross-reactivity of various tetrahydrocannabinol metabolites with a monoclonal antibody against tetrahydrocannabinolic acid

Watanabe, K., Matsuda, M., Tateoka, Y., Kimura, T., Matsunaga, T., Tanaka, H., Shoyama, Y. & Yamamoto, I., Jan 1 2000, In : Journal of Health Science. 46, 4, p. 310-313 4 p.

Research output: Contribution to journalArticle

Dronabinol
Metabolites
Monoclonal Antibodies
Acids
Cannabinoids
105 Citations (Scopus)

Cytotoxic lavandulyl flavanones from Sophora flavescens

Kang, T. H., Jeong, S. J., Ko, W. G., Kim, N. Y., Lee, B. H., Inagaki, M., Miyamoto, T., Higuchi, R. & Kim, Y. C., May 1 2000, In : Journal of Natural Products. 63, 5, p. 680-681 2 p.

Research output: Contribution to journalArticle

Sophora
Flavanones
Optical rotation
Optical Rotation
Myeloid Leukemia
9 Citations (Scopus)

Determination of 1,5-anhydro-glucitol-carrier protein conjugates matrix-assisted laser desorption/ionization tof mass spectrometry and antibody formation

Xuan, L. J., Tanaka, H., Morimoto, S., Shoyama, Y., Akanuma, H. & Muraoka, K., Jan 1 2000, In : Spectroscopy. 14, 3, p. 85-92 8 p.

Research output: Contribution to journalArticle

Sorbitol
Succinic Acid
Ionization
Mass spectrometry
Desorption

Determination of hybrids in Papaver species by RAPD, HPLC and ELISA

Shoyama, Y., Tanaka, H., Morimoto, S. & Taura, F., 2000, In : Japanese Journal of Forensic Toxicology. 18, 2, p. 160-161 2 p.

Research output: Contribution to journalArticle

Thebaine
Papaver
Enzyme-Linked Immunosorbent Assay
High Pressure Liquid Chromatography
Oligonucleotides
122 Citations (Scopus)

Effect of furanocoumarin derivatives in grapefruit juice on the uptake of vinblastine by Caco-2 cells and on the activity of cytochrome P450 3A4

Ohnishi, A., Matsuo, H., Yamada, S., Takanaga, H., Morimoto, S., Shoyama, Y., Ohtani, H. & Sawada, Y., Jan 1 2000, In : British Journal of Pharmacology. 130, 6, p. 1369-1377 9 p.

Research output: Contribution to journalArticle

Citrus paradisi
Cytochrome P-450 CYP3A
Caco-2 Cells
Vinblastine
P-Glycoprotein
2 Citations (Scopus)

ELISA, western blotting, immunocytolocalization and immunoaffinity column for naturally occuring bioactive compounds using monoclonal antibodies

Shan, S. J., Putalun, W., Fukuda, N., Morinaga, O., Tanaka, H. & Shoyama, Y., Dec 1 2000, In : Journal of Food and Drug Analysis. 8, 4, p. 258-269 12 p.

Research output: Contribution to journalReview article

glycyrrhizin
Glycyrrhizic Acid
monoclonal antibodies
Western blotting
Western Blotting
7 Citations (Scopus)

Expression and characterization of human rheumatoid factor single-chain Fv

Hashimoto, Y., Ikenaga, T., Tanigawa, K., Ueda, T., Ezaki, I. & Imoto, T., Jan 1 2000, In : Biological and Pharmaceutical Bulletin. 23, 8, p. 941-945 5 p.

Research output: Contribution to journalArticle

Single-Chain Antibodies
Rheumatoid Factor
Urea
Escherichia coli
Genetic Engineering
48 Citations (Scopus)

Formation of monoclonal antibody against a major ginseng component, ginsenoside Rg1 and its characterization: Monoclonal antibody for a ginseng saponin

Fukuda, N., Tanaka, H. & Shoyama, Y., Jan 1 2000, In : Cytotechnology. 34, 3, p. 197-204 8 p.

Research output: Contribution to journalArticle

Panax
Monoclonal antibodies
Saponins
Antigens
Ionization
1 Citation (Scopus)

Formation of monoclonal antibody against naturally occurring biologically active compounds and their application

Tanaka, H., Jun 1 2000, In : Natural Medicines. 54, 3, p. 123-128 6 p.

Research output: Contribution to journalArticle

Glycyrrhetinic Acid
Cannabinoids
Glucuronides
Cross Reactions
Colforsin
370 Citations (Scopus)

Genetic variants of IL-13 signalling and human asthma and atopy

Heinzmann, A., Mao, X. Q., Akaiwa, M., Kreomer, R. T., Gao, P. S., Ohshima, K., Umeshita, R., Abe, Y., Braun, S., Yamashita, T., Roberts, M. H., Sugimoto, R., Arima, K., Arinobu, Y., Yu, B., Kruse, S., Enomoto, T., Dake, Y., Kawai, M., Shimazu, S. & 12 others, Sasaki, S., Adra, C. N., Kitaichi, M., Inoue, H., Yamauchi, K., Tomichi, N., Kurimoto, F., Hamasaki, N., Hopkin, J. M., Izuhara, K., Shirakawa, T. & Deichmann, K. A., Mar 1 2000, In : Human Molecular Genetics. 9, 4, p. 549-559 11 p.

Research output: Contribution to journalArticle

Interleukin-13
Asthma
Immunoglobulin E
Smooth Muscle
Chromosomes
14 Citations (Scopus)

Heterooligomer of type 1 and type 2 inositol 1, 4, 5-trisphosphate receptor expressed in rat liver membrane fraction exists as tetrameric complex

Onoue, H., Tanaka, H., Tanaka, K., Doira, N. & Ito, Y., Jan 27 2000, In : Biochemical and Biophysical Research Communications. 267, 3, p. 928-933 6 p.

Research output: Contribution to journalArticle

Inositol 1,4,5-Trisphosphate Receptors
Liver
Rats
Monomers
Membranes
3 Citations (Scopus)

Histochemical investigation of β-glucuronidase in culture cells and regenerated plants of Scutellaria baicalensis Georgi

Matsuda, T., Hatano, K., Harioka, T., Taura, F., Tanaka, H., Tateishi, N., Shan, S., Morimoto, S. & Shoyama, Y., Mar 2000, In : Plant Cell Reports. 19, 4, p. 390-394 5 p.

Research output: Contribution to journalArticle

Scutellaria baicalensis
cell culture
trichomes
cells
leaf primordia
34 Citations (Scopus)

Hyaluronidase inhibitory active 6H-dibenzo[b,d]pyran-6-ones from the feces of Trogopterus xanthipes

Jeong, S. J., Kim, N. Y., Kim, D. H., Kang, T. H., Ahn, N. H., Miyamoto, T., Higuchi, R. & Kim, Y. C., Feb 26 2000, In : Planta medica. 66, 1, p. 76-77 2 p.

Research output: Contribution to journalArticle

Hyaluronoglucosaminidase
Feces
Bioassay
Fractionation
Biological Assay
90 Citations (Scopus)

Inhibition of P-glycoprotein by orange juice components, polymethoxyflavones in adriamycin-resistant human myelogenous leukemia (K562/ADM) cells

Ikegawa, T., Ushigome, F., Koyabu, N., Morimoto, S., Shoyama, Y., Naito, M., Tsuruo, T., Ohtani, H. & Sawada, Y., Nov 10 2000, In : Cancer Letters. 160, 1, p. 21-28 8 p.

Research output: Contribution to journalArticle

Myeloid Leukemia
K562 Cells
P-Glycoprotein
Doxorubicin
Citrus paradisi
42 Citations (Scopus)

Interaction between cytochrome P450 and other drug-metabolizing enzymes: Evidence for an association of CYP1A1 with microsomal epoxide hydrolase and UDP-glucuronosyltransferase

Taura, K. I., Yamada, H., Hagino, Y., Ishii, Y., Mori, M. A. & Oguri, K., Jul 14 2000, In : Biochemical and Biophysical Research Communications. 273, 3, p. 1048-1052 5 p.

Research output: Contribution to journalArticle

Epoxide Hydrolases
Glucuronosyltransferase
Cytochrome P-450 CYP1A1
Cytochrome P-450 Enzyme System
Association reactions
36 Citations (Scopus)

Isolation of the pharmacologically active saponin ginsenoside Rb1 from ginseng by immunoaffinity column chromatography

Fukuda, N., Tanaka, H. & Shoyama, Y., Feb 1 2000, In : Journal of Natural Products. 63, 2, p. 283-285 3 p.

Research output: Contribution to journalArticle

Column chromatography
Panax
Saponins
saponins
Chromatography
2 Citations (Scopus)

Letter to the editor: Assignment of 1H and 15N resonances of mouse lysozyme M [1]

Obita, T., Ueda, T., Tanaka, Y., Hashimoto, Y. & Imoto, T., Dec 1 2000, In : Journal of Biomolecular NMR. 18, 4, p. 361-362 2 p.

Research output: Contribution to journalLetter

Nitrogen Isotopes
Biomolecular Nuclear Magnetic Resonance
Secondary Protein Structure
Muramidase
Protons
24 Citations (Scopus)
Cathepsin B
Phosphorylation
Cysteine Proteases
Lysosomes
Oligosaccharides
17 Citations (Scopus)
Cathepsin H
Cysteine Proteases
Lysosomes
Hepatocytes
Methionine
33 Citations (Scopus)

Molecular characterization of a novel β-glucuronidase from Scutellaria baicalensis Georgi

Sasaki, K., Taura, F., Shoyama, Y. & Morimoto, S., Sep 1 2000, In : Journal of Biological Chemistry. 275, 35, p. 27466-27472 7 p.

Research output: Contribution to journalArticle

Scutellaria baicalensis
Glucuronidase
Scutellaria
Mutagenesis
Site-Directed Mutagenesis
13 Citations (Scopus)

Mutant DnaA proteins defective in duplex opening of oriC, the origin of chromosomal DNA replication in Escherichia coli

Takata, M., Guo, L., Katayama, T., Hase, M., Seyama, Y., Miki, T. & Sekimizu, K., Jan 31 2000, In : Molecular Microbiology. 35, 2, p. 454-462 9 p.

Research output: Contribution to journalArticle

Mutant Proteins
DNA Replication
Escherichia coli
Proteins
Complex Mixtures
10 Citations (Scopus)

Mutant mouse lysozyme carrying a minimal T cell epitope of hen egg lysozyme evokes high autoantibody response

Tsujihata, Y., So, T., Chijiiwa, Y., Hashimoto, Y., Hirata, M., Ueda, T. & Imoto, T., Oct 1 2000, In : Journal of Immunology. 165, 7, p. 3606-3611 6 p.

Research output: Contribution to journalArticle

T-Lymphocyte Epitopes
Muramidase
Autoantibodies
Egg White
hen egg lysozyme
74 Citations (Scopus)

Octamer transcription factor-1 enhances hepatic nuclear factor-1α- mediated activation of the human UDP glucuronosyltransferase 2B7 promoter

Ishii, Y., Hansen, A. J. & Mackenzie, P. I., May 22 2000, In : Molecular Pharmacology. 57, 5, p. 940-947 8 p.

Research output: Contribution to journalArticle

Octamer Transcription Factor-1
Hepatocyte Nuclear Factor 1
AT Rich Sequence
Genes
human UGT2B7 protein
122 Citations (Scopus)

Polymethoxylated flavones in orange juice are inhibitors of P- glycoprotein but not cytochrome P450 3A4

Takanaga, H., Ohnishi, A., Yamada, S., Matsuo, H., Morimoto, S., Shoyama, Y., Ohtani, H. & Sawada, Y., Apr 1 2000, In : Journal of Pharmacology and Experimental Therapeutics. 293, 1, p. 230-236 7 p.

Research output: Contribution to journalArticle

Flavones
Cytochrome P-450 CYP3A
Vinblastine
P-Glycoprotein
Caco-2 Cells
32 Citations (Scopus)

Production of monoclonal antibody against a major purgative component, sennoside A, its characterization and ELISA

Morinaga, O., Tanaka, H. & Shoyama, Y., Jul 1 2000, In : Analyst. 125, 6, p. 1109-1113 5 p.

Research output: Contribution to journalArticle

Cathartics
Immunization
Monoclonal antibodies
Antigens
Isomers
25 Citations (Scopus)

Relationship between local structure and stability in hen egg white lysozyme mutant with alanine substituted for glycine

Masumoto, K., Ueda, T., Motoshima, H. & Imoto, T., Dec 1 2000, In : Protein Engineering. 13, 10, p. 691-695 5 p.

Research output: Contribution to journalArticle

Egg White
Dihedral angle
Muramidase
Alanine
Glycine
18 Citations (Scopus)

Remarkable thermal stability of doubly intramolecularly cross-linked hen lysozyme

Ueda, T., Masumoto, K., Ishibashi, R., So, T. & Imoto, T., May 15 2000, In : Protein Engineering. 13, 3, p. 193-196 4 p.

Research output: Contribution to journalArticle

Muramidase
Thermodynamic stability
Enzymes
Hot Temperature
Denaturation
54 Citations (Scopus)

Rotundines A-C, three novel sesquiterpene alkaloids from Cyperus rotundus

Jeong, S. J., Miyamoto, T., Inagaki, M., Kim, Y. C. & Higuchi, R., May 1 2000, In : Journal of Natural Products. 63, 5, p. 673-675 3 p.

Research output: Contribution to journalArticle

Cyperus
Cyperus rotundus
Rhizome
Sesquiterpenes
Alkaloids
3 Citations (Scopus)

Sequence analyses of CYP2B genes and catalytic profiles for P450s in Qdj: Sprague-Dawley rats that lack response to the phenobarbital-mediated induction of CYP2B2

Yamada, H., Matsunaga, H., Tsuji, K., Matsumoto, S., Yamamoto, M., Ishii, Y., Omiecinski, C. J. & Oguri, K., Dec 7 2000, In : Journal of Pharmacology and Experimental Therapeutics. 295, 3, p. 986-993 8 p.

Research output: Contribution to journalArticle

Phenobarbital
Sequence Analysis
Sprague Dawley Rats
Cytochrome P-450 CYP2B1
Exons
16 Citations (Scopus)

Small guanosine triphosphatase Rho/Rho-associated kinase as a novel regulator of intracellular redistribution of lysosomes in invasive tumor cells

Nishimura, Y., Itoh, K., Yoshioka, K., Uehata, M. & Himeno, M., Jan 1 2000, In : Cell and tissue research. 301, 3, p. 341-351 11 p.

Research output: Contribution to journalArticle

rho-Associated Kinases
Cathepsin D
Guanosine
Lysosomes
Microtubules
30 Citations (Scopus)

Squid nerve sphingomyelin containing an unusual sphingoid base

Ohashi, Y., Tanaka, T., Akashi, S., Morimoto, S., Kishimoto, Y. & Nagai, Y., Jul 1 2000, In : Journal of Lipid Research. 41, 7, p. 1118-1124 7 p.

Research output: Contribution to journalArticle

Decapodiformes
Sphingomyelins
Starfish
Ions
Mass spectrometry
356 Citations (Scopus)

Structural basis of presequence recognition by the mitochondrial protein import receptor Tom20

Abe, Y., Shodai, T., Muto, T., Mihara, K., Torii, H., Nishikawa, S. I., Endo, T. & Kohda, D., Mar 3 2000, In : Cell. 100, 5, p. 551-560 10 p.

Research output: Contribution to journalArticle

Mitochondrial Proteins
Rats
Aldehyde Dehydrogenase
Peptides
Mitochondria
14 Citations (Scopus)

Suppression of carbonic anhydrase III in rat liver by a dioxin-related toxic compound, coplanar polychlorinated biphenyl, 3,3',4,4',5-pentachlorobiphenyl

Ikeda, M., Ishii, Y., Kato, H., Akazawa, D., Hatsumura, M., Ishida, T., Matsusue, K., Yamada, H. & Oguri, K., Aug 1 2000, In : Archives of Biochemistry and Biophysics. 380, 1, p. 159-164 6 p.

Research output: Contribution to journalArticle

3,4,5,3',4'-pentachlorobiphenyl
Carbonic Anhydrase III
Dioxins
Poisons
Polychlorinated Biphenyls
11 Citations (Scopus)

Survey of solasodine-type glycoalkaloids by western blotting and ELISA using anti-solamargine monoclonal antibody

Putalun, W., Tanaka, H., Yahara, S., Lhieochaiphan, S. & Shoyama, Y., Jan 2000, In : Biological and Pharmaceutical Bulletin. 23, 1, p. 72-75 4 p.

Research output: Contribution to journalArticle

Glycosides
Solanum
Western Blotting
Enzyme-Linked Immunosorbent Assay
Monoclonal Antibodies
18 Citations (Scopus)

Synthesis and absolute stereochemistry of the acyl moiety of quillajasaponins

Zhu, X., Yu, B., Hui, Y., Higuchi, R., Kusano, T. & Miyamoto, T., Jan 29 2000, In : Tetrahedron Letters. 41, 5, p. 717-719 3 p.

Research output: Contribution to journalArticle

Immunologic Adjuvants
Stereochemistry
octanoic acid
21 Citations (Scopus)

Thermodynamic consequences of grafting enhanced affinity toward the mutated antigen onto an antibody. The case of anti-lysozyme antibody HyHEL-10

Nishimiya, Y., Tsumoto, K., Shiroishi, M., Yutani, K. & Kumagai, I., Apr 28 2000, In : Journal of Biological Chemistry. 275, 17, p. 12813-12820 8 p.

Research output: Contribution to journalArticle

Muramidase
Thermodynamics
Anti-Idiotypic Antibodies
Antigens
Antibodies
26 Citations (Scopus)

Two new biologically active triterpene saponins from Acanthophyllum squarrosum

Gaidi, G., Miyamoto, T., Rustaiyan, A., Laurens, V. & Lacaille-Dubois, M. A., Dec 10 2000, In : Journal of Natural Products. 63, 11, p. 1497-1502 6 p.

Research output: Contribution to journalArticle

Triterpenes
Lymphocytes
Saponins
Assays
Nuclear magnetic resonance
1999
26 Citations (Scopus)
Biphenyl Compounds
Poisons
Polychlorinated Biphenyls
Unsaturated Fatty Acids
Arachidonic Acid