Research Output

1996
12 Citations (Scopus)

Dorisenones, cytotoxic spongian diterpenoids, from the nudibranch Chromodoris obsoleta

Miyamoto, T., Sakamoto, K., Arao, K., Komori, T., Higuchi, R. & Sasaki, T., Jun 10 1996, In : Tetrahedron. 52, 24, p. 8187-8198 12 p.

Research output: Contribution to journalArticle

35 Citations (Scopus)

Effective renaturation of denatured and reduced immunoglobulin G in vitro without assistance of chaperone

Maeda, Y., Ueda, T. & Imoto, T., Jan 1 1996, In : Protein Engineering. 9, 1, p. 95-100 6 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)

Effect of additives on the renaturation of reduced lysozyme in the presence of 4 M urea

Maeda, Y., Yamada, H., Ueda, T. & Imoto, T., May 1 1996, In : Protein Engineering. 9, 5, p. 461-465 5 p.

Research output: Contribution to journalArticle

79 Citations (Scopus)

Effect on DNA topology by DnaA protein, the initiation factor of chromosomal DNA replication in Escherichia coli

Mizushima, T., Katayama, T. & Sekimizu, K., Sep 22 1996, In : Biochemistry. 35, 35, p. 11512-11516 5 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)
11 Citations (Scopus)

Immunoaffinity column chromatography against forskolin using an anti-forskolin monoclonal antibody and its application

Yanagihara, H., Sakata, R., Minami, H., Tanaka, H., Shoyama, Y. & Murakami, H., Dec 10 1996, In : Analytica Chimica Acta. 335, 1-2, p. 63-70 8 p.

Research output: Contribution to journalArticle

35 Citations (Scopus)

Influence of cluster formation of acidic phospholipids on decrease in the affinity for ATP of DnaA protein

Mizushima, T., Ishikawa, Y., Obana, E., Hase, M., Kubota, T., Katayama, T., Kunitake, T., Watanabe, E. & Sekimizu, K., Feb 16 1996, In : Journal of Biological Chemistry. 271, 7, p. 3633-3638 6 p.

Research output: Contribution to journalArticle

49 Citations (Scopus)

Molecular design of inhibitors of in vitro oriC DNA replication based on the potential to block the ATP binding of DnaA protein

Mizushima, T., Sasaki, S., Ohishi, H., Kobayashi, M., Katayama, T., Miki, T., Maeda, M. & Sekimizu, K., Oct 19 1996, In : Journal of Biological Chemistry. 271, 41, p. 25178-25183 6 p.

Research output: Contribution to journalArticle

36 Citations (Scopus)

Monoclonal antibody based enzyme immunoassay for marihuana (cannabinoid) compounds

Tanaka, H., Goto, Y. & Shoyama, Y., Jan 1 1996, In : Journal of Immunoassay. 17, 4, p. 321-342 22 p.

Research output: Contribution to journalArticle

51 Citations (Scopus)
75 Citations (Scopus)

Purification of a phenobarbital-inducible UDP-glucuronosyltransferase isoform from dog liver which catalyzes morphine and testosterone glucuronidation

Oguri, K., Kurogi, A., Yamabe, K. I., Tanaka, M., Yoshisue, K., Ishii, Y. & Yoshimura, H., Jan 15 1996, In : Archives of Biochemistry and Biophysics. 325, 2, p. 159-166 8 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)

Reduced immunogenicity of monomethoxypolyethylene glycol-modified lysozyme for activation of T cells

So, T., Ito, H. O., Koga, T., Ueda, T. & Imoto, T., Jan 1 1996, In : Immunology Letters. 49, 1-2, p. 91-97 7 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

Roles of dopamine D1 receptors in Δ9-tetrahydrocannabinol-induced expression of Fos protein in the rat brain

Miyamoto, A., Yamamoto, T., Ohno, M., Watanabe, S., Tanaka, H., Morimoto, S. & Shoyama, Y., Feb 26 1996, In : Brain Research. 710, 1-2, p. 234-240 7 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)
20 Citations (Scopus)

Situation of monomethoxypolyethylene glycol covalently attached to lysozyme

So, T., Ueda, T., Abe, Y., Nakamata, T. & Imoto, T., Jun 1996, In : Journal of biochemistry. 119, 6, p. 1086-1093 8 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Stabilization of lysozyme by introducing N-glycosylation signal sequence

Ueda, T., Iwashita, H., Hashimoto, Y. & Imoto, T., Jan 1 1996, In : Journal of Biochemistry. 119, 1, p. 157-161 5 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

The nucleoid protein H-NS facilitates chromosome DNA replication in Escherichia coli dnaA mutants

Katayama, T., Takata, M. & Sekimizu, K., Jan 1 1996, In : Journal of bacteriology. 178, 19, p. 5790-5792 3 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

The possible role of nitric oxide in relaxations and excitatory neuroeffector transmission in the cat airway

Tanaka, H., Jing, L., Takahashi, S. & Ito, Y., Jun 15 1996, In : Journal of Physiology. 493, 3, p. 785-791 7 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)
1995

Aplyparvunin, a bioactive acetogenin from the sea hare Aplysia parvula

Miyamoto, T., Ebisawa, Y. & Higuchi, R., Aug 21 1995, In : Tetrahedron Letters. 36, 34, p. 6073-6074 2 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Bioactive diterpenoids from octocorallia, 2. deoxyxeniolide B, a novel ichthyotoxic diterpenoid from the soft coral xenia elongata

Miyamoto, T., Takenaka, Y., Yamada, K. & Higuchi, R., Jun 1995, In : Journal of Natural Products. 58, 6, p. 924-928 5 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Biochemical characterization of liver microsomal, golgi, lysosomal, and serum β-glucuronidases in dibuty1 phosphate-treated rats

Nishimura, Y., Kato, K. & Himeno, M., Jan 1 1995, In : Journal of biochemistry. 118, 1, p. 56-66 11 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Biochemical Properties and Intracellular Processing of Lysosomal Cathepsins B and H

Nishimura, Y., Tsuji, H., Kato, K., Sato, H., Amano, J., Himeno, M. & Tsuji, H., Jan 1 1995, In : Biological and Pharmaceutical Bulletin. 18, 6, p. 829-836 8 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Biosynthesis, processing, and lysosome targeting of acid phosphatase

Himeno, M. & Tanaka, Y., Jan 1 1995, In : Nippon rinsho. Japanese journal of clinical medicine. 53, 12, p. 2898-2903 6 p.

Research output: Contribution to journalReview article

2 Citations (Scopus)

Biosynthesis and Processing of Lysosomal Cathepsin D in Primary Cultures of Rat Hepatocytes

Nishimura, Y., Kato, K., Himeno, M. & Koji, F., Jan 1 1995, In : Biological and Pharmaceutical Bulletin. 18, 6, p. 825-828 4 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Cannabinerolic acid, a cannabinoid from Cannabis sativa

Taura, F., Morimoto, S. & Shoyama, Y., Jan 1 1995, In : Phytochemistry. 39, 2, p. 457-458 2 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Cathepsin D associates with lysosomal membranous protein

Nishimura, Y. & Himeno, M., Jan 1 1995, In : Biological and Pharmaceutical Bulletin. 18, 10, p. 1340-1346 7 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Characterization of Escherichia coli DnaAcos protein in replication systems reconstituted with highly purified proteins

Katayama, T., Crooke, E. & Sekimizu, K., Dec 1995, In : Molecular Microbiology. 18, 5, p. 813-820 8 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Correlation between the differences in the free energy change and conformational energy in the folded state of hen lysozymes with gly-pro and pro-gly sequences introduced to the same site

Motoshima, H., Ueda, T., Hashimoto, Y., Tsutsumi, M. & Imoto, T., Dec 1995, In : Journal of biochemistry. 118, 6, p. 1138-1144 7 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Effective renaturation of reduced lysozyme by gentle removal of urea

Maeda, Y., Koga, H., Yamada, H., Ueda, T. & Imoto, T., Feb 1 1995, In : Protein Engineering, Design and Selection. 8, 2, p. 201-205 5 p.

Research output: Contribution to journalArticle

72 Citations (Scopus)

Effect of a coplanar PCB on lipid metabolism: the remarkable difference between rats and guinea pigs

Hatsumura, M., Ishida, T., Ishii, Y., Ariyoshi, N., Oguri, K. & Yoshimura, H., Jan 1 1995, In : Fukuoka igaku zasshi = Hukuoka acta medica. 86, 5, p. 135-143 9 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Effect of salt concentration on the pKa of acidic residues in lysozyme

Abe, Y., Ueda, T., Iwashita, H., Hashimoto, Y., Motoshima, H., Tanaka, Y. & Imoto, T., Oct 1 1995, In : Journal of biochemistry. 118, 5, p. 946-952 7 p.

Research output: Contribution to journalArticle

38 Citations (Scopus)

Expression of rat cathepsin D cDNA in Saccharomyces cerevisiae: Intracellular sorting of cathepsin D to yeast vacuole

Nishimura, Y., Fujita, H., Kato, K. & Himeno, M., Jan 1 1995, In : Advances in experimental medicine and biology. 362, p. 289-292 4 p.

Research output: Contribution to journalArticle

Expression of rat cathepsin D cDNA in Saccharomyces cerevisiae: Implications for intracellular targeting of cathepsin D to vacuoles

Nishimura, Y., Takeshima, H., Sakaguchi, M., Mihara, K., Omura, T., Kato, K. & Himeno, M., Jul 1995, In : Journal of biochemistry. 118, 1, p. 168-177 10 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

First Direct Evidence for the Mechanism of Δ1-Tetrahydrocannabinolie Acid Biosynthesis

Taura, F., Morimoto, S., Shoyama, Y. & Mechoulam, R., Jan 1 1995, In : Journal of the American Chemical Society. 117, 38, p. 9766-9767 2 p.

Research output: Contribution to journalArticle

89 Citations (Scopus)

Inhibitory Effect of Ethanol and Colchicine on the Intracellular Processing of β-Glucuronidase Which Occurs in the Golgi Complex

Nishimura, Y., Kato, K., Himeno, M. & Oda, K., Jan 1 1995, In : Biological and Pharmaceutical Bulletin. 18, 7, p. 938-944 7 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Inhibitory Effect of Leupeptin on the Intracellular Maturation of Lysosomal Cathepsin L in Primary Cultures of Rat Hepatocytes

Nishimura, Y., Kato, K., Himeno, M. & Furuno, K., Jan 1 1995, In : Biological and Pharmaceutical Bulletin. 18, 7, p. 945-950 6 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Intracellular sorting of lysosomal β-glucuronidase is altered due to administaration of dibutyl phosphate

Nishimura, Y., Kato, K., Oda, K., Ishikawa, T., Ikehara, Y. & Himeno, M., Jan 1 1995, In : Journal of biochemistry. 118, 1, p. 46-55 10 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Intracellular targeting of lysosomal cathepsin D in COS cells

Takeshima, H., Sakaguchi, M., Mihara, K., Murakami, K., Omura, T., Himeno, M. & Nishimura, Y., Oct 1 1995, In : Journal of biochemistry. 118, 5, p. 981-988 8 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Isolation and characterization of inhibitory factors of DNA polymerase III holoenzyme from Escherichia coli

Hase, M., Mizushima, T., Katayama, T. & Sekimizu, K., Aug 1 1995, In : FEMS microbiology letters. 130, 2-3, p. 215-220 6 p.

Research output: Contribution to journalArticle

Kinetically Trapped Structure in the Renaturation of Reduced Oxindolealanine 62 Lysozyme

Ueda, T., Abe, Y., Ohkuri, T., Kawano, K., Terada, Y. & Imoto, T., Dec 1995, In : Biochemistry. 34, 49, p. 16178-16185 8 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Purification and characterization of a newly identified isoform of cytochrome P450 responsible for 3-hydroxylation of 2, 5, 2', 5'-tetrachlorobiphenyl in hamster liver

Koga, N., Kikuichi-Nishimura, N., Hara, T., Harada, N., Ishii, Y., Yamada, H., Oguri, K. & Yoshimura, H., Mar 10 1995, In : Archives of Biochemistry and Biophysics. 317, 2, p. 464-470 7 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)

Purification and characterization of flavone-specific β-glucuronidase from callus cultures of Scutellaria baicalensis Georgi

Morimoto, S., Harioka, T. & Shoyama, Y., Feb 1 1995, In : Planta. 195, 4, p. 535-540 6 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

Structure determination of the major component of the starfish ganglioside molecular species LG-2 by tandem mass spectrometry

Higuchi, R., Matsumoto, S., Isobe, R. & Miyamoto, T., Aug 14 1995, In : Tetrahedron. 51, 33, p. 8961-8968 8 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)
1994

Bioactive terpenoids from Octocorallia, I. Bioactive diterpenoids: Litophynols A and B from the mucus of the soft coral Litophyton sp.

Miyamoto, T., Yamada, K., Ikeda, N., Komori, T. & Higuchi, R., Sep 1 1994, In : Journal of Natural Products. 57, 9, p. 1212-1219 8 p.

Research output: Contribution to journalArticle

48 Citations (Scopus)

Constituents of holothuroideae, IV. Isolation and structure of three new cerebrosides, CE‐2b, CE‐2c and CE‐2d, from the sea cucumber Cucumaria echinata

Higuchi, R., Inagaki, M., Togawa, K., Miyamoto, T. & Komori, T., Jan 1 1994, In : Liebigs Annalen der Chemie. 1994, 1, p. 79-81 3 p.

Research output: Contribution to journalArticle

32 Citations (Scopus)

Constituents of Holothuroideae, V. Isolation and Structure of Cerebrosides from the Sea Cucumber Pentacta australis

Higuchi, R., Inagaki, M., Togawa, K., Miyamoto, T. & Komori, T., Jan 1 1994, In : Liebigs Annalen der Chemie. 1994, 7, p. 653-658 6 p.

Research output: Contribution to journalArticle

59 Citations (Scopus)

Determination of tetrahydrocannabinolic acid—carrier protein conjugate by matrix‐assisted laser desorption/ionization mass spectrometry and antibody formation

Goto, Y., Shima, Y., Morimoto, S., Shoyama, Y., Murakami, H., Kusai, A. & Nojima, K., Jan 1 1994, In : Organic Mass Spectrometry. 29, 11, p. 668-671 4 p.

Research output: Contribution to journalArticle

41 Citations (Scopus)

Effect of coplanar PCB on gluconeogenesis and lipid metabolism: Comparison between rats and guinea pigs

Hatsumura, M., Ishida, T., Ishii, Y., Ariyoshi, N., Koga, Y., Oguri, K. & Yoshimura, H., Jan 1 1994, In : Japanese Journal of Toxicology and Environmental Health. 40, 1, p. P27

Research output: Contribution to journalArticle

Formation of α-helix 88-98 is essential in the establishment of higher-order structure from reduced lysozyme

Ueda, T., Nakashima, A., Hashimoto, Y., Miki, T., Yamada, H. & Imoto, T., Jan 27 1994, In : Journal of Molecular Biology. 235, 4, p. 1312-1317 6 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)