Research Center for Transomics Medicine

Research Output

Dietary Intake of Curcumin Improves eIF2 Signaling and Reduces Lipid Levels in the White Adipose Tissue of Obese Mice

Kobori, M., Takahashi, Y., Takeda, H., Takahashi, M., Izumi, Y., Akimoto, Y., Sakurai, M., Oike, H., Nakagawa, T., Itoh, M., Bamba, T. & Kimura, T., Dec 1 2018, In : Scientific reports. 8, 1, 9081.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Differential lactate and cholesterol synthetic activities in XY and XX Sertoli cells

Shishido, Y., Baba, T., Sato, T., Shima, Y., Miyabayashi, K., Inoue, M., Akiyama, H., Kimura, H., Kanai, Y., Ishihara, Y., Haraguchi, S., Miyazaki, A., Rozman, D., Yamazaki, T., Choi, M. H., Ohkawa, Y., Suyama, M. & Morohashi, K. I., Jan 1 2017, In : Scientific reports. 7, 41912.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Direct isolation and RNA-seq reveal environment-dependent properties of engrafted neural stem/progenitor cells

Kumamaru, H., Ohkawa, Y., Saiwai, H., Yamada, H., Kubota, K., Kobayakawa, K., Akashi, K., Okano, H., Iwamoto, Y. & Okada, S., Nov 26 2012, In : Nature communications. 3, 1140.

Research output: Contribution to journalArticle

41 Citations (Scopus)

Direct isopropanol production from cellobiose by engineered Escherichia coli using a synthetic pathway and a cell surface display system

Soma, Y., Inokuma, K., Tanaka, T., Ogino, C., Kondo, A., Okamoto, M. & Hanai, T., Jul 1 2012, In : Journal of Bioscience and Bioengineering. 114, 1, p. 80-85 6 p.

Research output: Contribution to journalArticle

41 Citations (Scopus)

Direct reprogramming of spiral ganglion non-neuronal cells into neurons: Toward ameliorating sensorineural hearing loss by gene therapy

Noda, T., Meas, S. J., Nogami, J., Amemiya, Y., Uchi, R., Ohkawa, Y., Nishimura, K. & Dabdoub, A., Feb 14 2018, In : Frontiers in Cell and Developmental Biology. 6, FEB, 16.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Discovery of the Gene Encoding a Novel Small Serum Protein (SSP) of Protobothrops flavoviridis and the Evolution of SSPs

Inamaru, K., Takeuchi, A., Maeda, M., Shibata, H., Fukumaki, Y., Oda-Ueda, N., Hattori, S., Ohno, M. & Chijiwa, T., Jan 1 2020, In : Toxins. 12, 3, 177.

Research output: Contribution to journalArticle

Open Access

Distinct signatures of dental plaque metabolic byproducts dictated by periodontal inflammatory status

Sakanaka, A., Kuboniwa, M., Hashino, E., Bamba, T., Fukusaki, E. & Amano, A., Feb 21 2017, In : Scientific reports. 7, 42818.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Distribution of histone H4 modifications as revealed by a panel of specific monoclonal antibodies

Hayashi-Takanaka, Y., Maehara, K., Harada, A., Umehara, T., Yokoyama, S., Obuse, C., Ohkawa, Y., Nozaki, N. & Kimura, H., Dec 1 2015, In : Chromosome Research. 23, 4, p. 753-766 14 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Diversity in the matrix structure of eggshells in the testudines (reptilia)

Kusuda, S., Yasukawa, Y., Shibata, H., Saito, T., Doi, O., Ohya, Y. & Yoshizaki, N., May 1 2013, In : Zoological science. 30, 5, p. 366-374 9 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Dmrt factors determine the positional information of cerebral cortical progenitors via differential suppression of homeobox genes

Konno, D., Kishida, C., Maehara, K., Ohkawa, Y., Kiyonari, H., Okada, S. & Matsuzaki, F., Aug 2019, In : Development (Cambridge). 146, 15, dev174243.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

DNA methylation and gene expression dynamics during spermatogonial stem cell differentiation in the early postnatal mouse testis

Kubo, N., Toh, H., Shirane, K., Shirakawa, T., Kobayashi, H., Sato, T., Sone, H., Sato, Y., Tomizawa, S. I., Tsurusaki, Y., Shibata, H., Saitsu, H., Suzuki, Y., Matsumoto, N., Suyama, M., Kono, T., Ohbo, K. & Sasaki, H., Aug 20 2015, In : BMC genomics. 16, 1, 624.

Research output: Contribution to journalArticle

53 Citations (Scopus)

DNA methylation of the Klf14 gene region in whole blood cells provides prediction for the chronic inflammation in the adipose tissue

Iwaya, C., Kitajima, H., Yamamoto, K., Maeda, Y., Sonoda, N., Shibata, H. & Inoguchi, T., Mar 11 2018, In : Biochemical and Biophysical Research Communications. 497, 3, p. 908-915 8 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Does ossification of the posterior longitudinal ligament affect the neurological outcome after traumatic cervical cord injury?

Okada, S., Maeda, T., Ohkawa, Y., Harimaya, K., Saiwai, H., Kumamaru, H., Matsumoto, Y., Doi, T., Ueta, T., Shiba, K. & Iwamoto, Y., May 15 2009, In : Spine. 34, 11, p. 1148-1152 5 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

Dynamic regulation of ubiquitylation and deubiquitylation at the central spindle during cytokinesis

Mukai, A., Mizuno, E., Kobayashi, K., Matsumoto, M., Nakayama, K. I., Kitamura, N. & Komada, M., Apr 15 2008, In : Journal of Cell Science. 121, 8, p. 1325-1333 9 p.

Research output: Contribution to journalArticle

35 Citations (Scopus)

Effect of Furan Fatty Acids and 3-Methyl-2,4-nonanedione on Light-Induced Off-Odor in Soybean Oil

Sano, T., Okabe, R., Iwahashi, M., Imagi, J., Sato, T., Yamashita, T., Fukusaki, E. & Bamba, T., Mar 15 2017, In : Journal of Agricultural and Food Chemistry. 65, 10, p. 2136-2140 5 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Engrafted Neural Stem/Progenitor Cells Promote Functional Recovery through Synapse Reorganization with Spared Host Neurons after Spinal Cord Injury

Yokota, K., Kobayakawa, K., Kubota, K., Miyawaki, A., Okano, H., Ohkawa, Y., Iwamoto, Y. & Okada, S., Jan 1 2015, In : Stem Cell Reports. 5, 2, p. 264-277 14 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)
2 Citations (Scopus)

Epiregulin as a Major Autocrine/Paracrine Factor Released from ERK- and p38MAPK-Activated Vascular Smooth Muscle Cells

Takahashi, M., Hayashi, K., Yoshida, K., Ohkawa, Y., Komurasaki, T., Kitabatake, A., Ogawa, A., Nishida, W., Yano, M., Monden, M. & Sobue, K., Nov 18 2003, In : Circulation. 108, 20, p. 2524-2529 6 p.

Research output: Contribution to journalArticle

49 Citations (Scopus)

Erratum: A novel protein with RNA-binding motifs interacts with ataxin-2 (Human Molecular Genetics (2000) vol.9 (1303-1313))

Shibata, H., Huynh, D. P. & Pulst, S. M., Aug 17 2000, In : Human Molecular Genetics. 9, 12, 1 p.

Research output: Contribution to journalComment/debate

1 Citation (Scopus)

Erratum: Heterochromatin dynamics during the differentiation process revealed by the DNA methylation reporter mouse, MethylRO (Stem Cell Reports (2014) 2 (910-924))

Ueda, J., Maehara, K., Mashiko, D., Ichinose, T., Yao, T., Hori, M., Sato, Y., Kimura, H., Ohkawa, Y. & Yamagata, K., Jul 8 2014, In : Stem Cell Reports. 3, 1, 1 p.

Research output: Contribution to journalComment/debate

Erratum: PSMC5, a 19S proteasomal ATPase, regulates cocaine action in the nucleus accumbens (PLoS ONE (2015) 10:5 (e0126710) DOI: 10.1371/journal.pone.0126710)

Ohnishi, Y. H., Ohnishi, Y. N., Nakamura, T., Ohno, M., Kennedy, P. J., Ohkawa, Y., Nishi, A., Neve, R., Tsuzuki, T. & Nestler, E. J., Jun 25 2015, In : PloS one. 10, 6, e0131263.

Research output: Contribution to journalComment/debate

Erratum: Transcription Factor PU.1 Represses and Activates Gene Expression in Early T Cells by Redirecting Partner Transcription Factor Binding (Immunity (2018) 48(6) (1119–1134.e7), (S1074761318301936) (10.1016/j.immuni.2018.04.024))

Hosokawa, H., Ungerbäck, J., Wang, X., Matsumoto, M., Nakayama, K. I., Cohen, S. M., Tanaka, T. & Rothenberg, E. V., Oct 16 2018, In : Immunity. 49, 4, 1 p.

Research output: Contribution to journalComment/debate

1 Citation (Scopus)

Erratum: New Insight into the Role of the Calvin Cycle: Reutilization of CO2 Emitted through Sugar Degradation (Scientific Reports 5 (2016) (11617) DOI: 10.1038/srep11617)

Shimizu, R., Dempo, Y., Nakayama, Y., Nakamura, S., Bamba, T., Fukusaki, E. & Fukui, T., Jun 20 2016, In : Scientific reports. 6, 27961.

Research output: Contribution to journalComment/debate

Erratum: Structure and function of human histone H3.Y nucleosome (Nucleic acids research (2016) 44 13 (6127-6141))

Kujirai, T., Horikoshi, N., Sato, K., Maehara, K., Machida, S., Osakabe, A., Kimura, H., Ohkawa, Y. & Kurumizaka, H., Apr 7 2017, In : Nucleic acids research. 45, 6, 1 p.

Research output: Contribution to journalComment/debate

1 Citation (Scopus)

Establishment of neutralizing rat monoclonal antibodies for fibroblast growth factor-2

Tanaka, M., Yamaguchi, M., Shiota, M., Kawamoto, Y., Takahashi, K., Inagaki, A., Osada-Oka, M., Harada, A., Wanibuchi, H., Izumi, Y., Miura, K., Iwao, H. & Ohkawa, Y., Aug 1 2014, In : Monoclonal Antibodies in Immunodiagnosis and Immunotherapy. 33, 4, p. 261-269 9 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Evolutionary relationships and sequence variation of α-amylase variants encoded by duplicated genes in the Amy locus of Drosophila melanogaster

Inomata, N., Shibata, H., Okuyama, E. & Yamazaki, T., Jan 1 1995, In : Genetics. 141, 1, p. 237-244 8 p.

Research output: Contribution to journalArticle

42 Citations (Scopus)

Evolution of the sperm methylome of primates is associated with retrotransposon insertions and genome instability

Fukuda, K., Inoguchi, Y., Ichiyanagi, K., Ichiyanagi, T., Go, Y., Nagano, M., Yanagawa, Y., Takaesu, N., Ohkawa, Y., Imai, H. & Sasaki, H., Sep 2017, In : Human Molecular Genetics. 26, 18, p. 3508-3519 12 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Exploration of nucleosome positioning patterns in transcription factor function

Maehara, K. & Ohkawa, Y., Jan 21 2016, In : Scientific reports. 6, 19620.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Facultative parthenogenesis validated by DNA analyses in the green anaconda (Eunectes murinus)

Shibata, H., Sakata, S., Hirano, Y., Nitasaka, E. & Sakabe, A., Dec 2017, In : PloS one. 12, 12, e0189654.

Research output: Contribution to journalArticle

4 Citations (Scopus)

F-box and WD repeat domain-containing-7 (Fbxw7) protein targets endoplasmic reticulum-anchored osteogenic and chondrogenic transcriptional factors for degradation

Yumimoto, K., Matsumoto, M., Onoyama, I., Imaizumi, K. & Nakayama, K. I., Oct 4 2013, In : Journal of Biological Chemistry. 288, 40, p. 28488-28502 15 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Fbw7 targets GATA3 through cyclin-dependent kinase 2-dependent proteolysis and contributes to regulation of T-cell development

Kitagawa, K., Shibat, K., Matsumoto, A., Matsumoto, M., Ohhata, T., Nakayama, K. I., Niida, H. & Kitagawa, M., Jul 2014, In : Molecular and cellular biology. 34, 14, p. 2732-2744 13 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

FBXL21 regulates oscillation of the circadian clock through ubiquitination and stabilization of cryptochromes

Hirano, A., Yumimoto, K., Tsunematsu, R., Matsumoto, M., Oyama, M., Kozuka-Hata, H., Nakagawa, T., Lanjakornsiripan, D., Nakayama, K. I. & Fukada, Y., Feb 28 2013, In : Cell. 152, 5, p. 1106-1118 13 p.

Research output: Contribution to journalArticle

131 Citations (Scopus)

Fbxo45, a novel ubiquitin ligase, regulates synaptic activity

Tada, H., Okano, H. J., Takagi, H., Shibata, S., Yao, I., Matsumoto, M., Saiga, T., Nakayama, K. I., Kashima, H., Takahashi, T., Setou, M. & Okano, H., Feb 5 2010, In : Journal of Biological Chemistry. 285, 6, p. 3840-3849 10 p.

Research output: Contribution to journalArticle

46 Citations (Scopus)

Fbxo45 forms a novel ubiquitin ligase complex and is required for neuronal development

Saiga, T., Fukuda, T., Matsumoto, M., Tada, H., Okano, H. J., Okano, H. & Nakayama, K. I., Jul 1 2009, In : Molecular and cellular biology. 29, 13, p. 3529-3543 15 p.

Research output: Contribution to journalArticle

68 Citations (Scopus)

Fetal leydig cells dedifferentiate and serve as adult leydig stem cells

Shima, Y., Miyabayashi, K., Sato, T., Suyama, M., Ohkawa, Y., Doi, M., Okamura, H. & Suzuki, K., Dec 2018, In : Development (Cambridge). 145, 23, dev169136.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Flow cytometric sorting of neuronal and glial nuclei from central nervous system tissue

Okada, S., Saiwai, H., Kumamaru, H., Kubota, K., Harada, A., Yamaguchi, M., Iwamoto, Y. & Ohkawa, Y., Feb 1 2011, In : Journal of cellular physiology. 226, 2, p. 552-558 7 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Foxl3 is a germ cell-intrinsic factor involved in sperm-egg fate decision in medaka

Nishimura, T., Sato, T., Yamamoto, Y., Watakabe, I., Ohkawa, Y., Suyama, M., Kobayashi, S. & Tanaka, M., Jul 17 2015, In : Science. 349, 6245, p. 328-331 4 p.

Research output: Contribution to journalArticle

49 Citations (Scopus)

Frequent detection of pituitary-derived PRPREs in human prion diseases

Honda, H., Matsumoto, M., Shijo, M., Hamasaki, H., Sadashima, S., Suzuki, S. O., Aishima, S., Kai, K., Nakayama, K. I., Sasagasako, N. & Iwaki, T., Oct 1 2019, In : Journal of neuropathology and experimental neurology. 78, 10, p. 922-929 8 p.

Research output: Contribution to journalArticle

Functional analyses of the activation loop of phototropin2 in Arabidopsis

Inoue, S. I., Matsushita, T., Tomokiyo, Y., Matsumoto, M., Nakayama, K. I., Kinoshita, T. & Shimazaki, K. I., May 1 2011, In : Plant physiology. 156, 1, p. 117-128 12 p.

Research output: Contribution to journalArticle

53 Citations (Scopus)
49 Citations (Scopus)

Gas chromatography-mass spectrometry metabolomics-based prediction of potato tuber sprouting during long-term storage

Fukuda, T., Takamatsu, K., Bamba, T. & Fukusaki, E., Aug 1 2019, In : Journal of Bioscience and Bioengineering. 128, 2, p. 249-254 6 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Generation of a monoclonal antibody for INI1/hSNF5/BAF47

Harada, A., Hayashi, M., Kuniyoshi, Y., Semba, Y., Sugahara, S., Tachibana, T., Ohkawa, Y. & Fujita, M., Feb 1 2014, In : Monoclonal Antibodies in Immunodiagnosis and Immunotherapy. 33, 1, p. 49-51 3 p.

Research output: Contribution to journalArticle

Generation of a rat monoclonal antibody specific for Brm

Okada, S., Harada, A., Saiwai, H., Nakamura, M. & Ohkawa, Y., Dec 1 2009, In : Hybridoma. 28, 6, p. 455-458 4 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Generation of a rat monoclonal antibody specific for Chd2

Harada, A., Yoshimura, S., Odawara, J., Azuma, M., Okada, S., Nakamura, M., Tachibana, T. & Ohkawa, Y., Apr 1 2010, In : Hybridoma. 29, 2, p. 173-177 5 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Generation of a rat monoclonal antibody specific for heat shock cognate protein 70

Shiota, M., Saiwai, H., Mun, S., Harada, A., Okada, S., Odawara, J., Tanaka, M., Iwao, H. & Ohkawa, Y., Oct 1 2010, In : Hybridoma. 29, 5, p. 453-456 4 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Generation of a rat monoclonal antibody specific for Hsp72

Tanaka, M., Shiota, M., Okada, S., Harada, A., Odawara, J., Mun, S., Iwao, H. & Ohkawa, Y., Aug 1 2011, In : Hybridoma. 30, 4, p. 397-400 4 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Generation of a rat monoclonal antibody specific for Pax7

Harada, A., Okada, S., Saiwai, H., Aoki, M., Nakamura, M. & Ohkawa, Y., Dec 1 2009, In : Hybridoma. 28, 6, p. 451-453 3 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Genetic reevaluation of the Role of F-Box proteins in cyclin D1 degradation

Kanie, T., Onoyama, I., Matsumoto, A., Yamada, M., Nakatsumi, H., Tateishi, Y., Yamamura, S., Tsunematsu, R., Matsumoto, M. & Nakayama, K. I., Feb 1 2012, In : Molecular and cellular biology. 32, 3, p. 590-605 16 p.

Research output: Contribution to journalArticle

39 Citations (Scopus)

Genome-wide analysis of histone modifications in human endometrial stromal cells

Tamura, I., Ohkawa, Y., Sato, T., Suyama, M., Jozaki, K., Okada, M., Lee, L., Maekawa, R., Asada, H., Sato, S., Yamagata, Y., Tamura, H. & Sugino, N., Oct 1 2014, In : Molecular Endocrinology. 28, 10, p. 1656-1669 14 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)