Research Center for Transomics Medicine

Research Output 1994 2020

2004
313 Citations (Scopus)

VHL-box and SOCS-box domains determine binding specificity for Cul2-Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases

Kamura, T., Maenaka, K., Kotoshiba, S., Matsumoto, M., Kohda, D., Conaway, R. C., Conaway, J. W. & Nakayama, K. I., Dec 15 2004, In : Genes and Development. 18, 24, p. 3055-3065 11 p.

Research output: Contribution to journalArticle

Suppressor of Cytokine Signaling Proteins
Ligases
Ubiquitin
Cullin Proteins
RNA Interference
2003
23 Citations (Scopus)

Analysis of long-chain polyprenols using supercritical fluid chromatography and matrix-assisted laser desorption ionization time-of-flight mass spectrometry

Bamba, T., Fukusaki, E., Nakazawa, Y., Sato, H., Ute, K., Kitayama, T. & Kobayashi, A., May 2 2003, In : Journal of Chromatography A. 995, 1-2, p. 203-207 5 p.

Research output: Contribution to journalArticle

Supercritical Fluid Chromatography
Ionization
Mass spectrometry
Desorption
Mass Spectrometry
47 Citations (Scopus)

Characterization of the mouse gene for the U-box-type ubiquitin ligase UFD2a

Kaneko, C., Hatakeyama, S., Matsumoto, M., Yada, M., Nakayama, K. & Nakayama, K., Jan 10 2003, In : Biochemical and Biophysical Research Communications. 300, 2, p. 297-304 8 p.

Research output: Contribution to journalArticle

Ligases
Ubiquitin
Genes
TATA Box
5' Flanking Region
6 Citations (Scopus)

Glutamate receptor genes as candidates for schizophrenia susceptibility

Fukumaki, Y. & Shibata, H., Oct 1 2003, In : Drug Development Research. 60, 2, p. 137-151 15 p.

Research output: Contribution to journalReview article

Glutamate Receptors
Schizophrenia
Genes
Endophenotypes
Haplotypes
47 Citations (Scopus)

Positive association of the AMPA receptor subunit GluR4 gene (GRIA4) haplotype with schizophrenia: Linkage disequilibrium mapping using SNPs evenly distributed across the gene region

Makino, C., Fujii, Y., Kikuta, R., Hirata, N., Tani, A., Shibata, A., Ninomiya, H., Tashiro, N., Shibata, H. & Fukumaki, Y., Jan 1 2003, In : American Journal of Medical Genetics - Neuropsychiatric Genetics. 116 B, 1, p. 17-22 6 p.

Research output: Contribution to journalArticle

Chromosome Mapping
Linkage Disequilibrium
Haplotypes
Single Nucleotide Polymorphism
Schizophrenia
99 Citations (Scopus)

Positive associations of polymorphisms in the metabotropic glutamate receptor type 3 gene (GRM3) with schizophrenia

Fujii, Y., Shibata, H., Kikuta, R., Makino, C., Tani, A., Hirata, N., Shibata, A., Ninomiya, H., Tashiro, N. & Fukumaki, Y., Jun 2003, In : Psychiatric Genetics. 13, 2, p. 71-76 6 p.

Research output: Contribution to journalArticle

Schizophrenia
Haplotypes
Single Nucleotide Polymorphism
Genes
Gene Frequency
51 Citations (Scopus)

Preferential interaction of TIP120A with Cul1 that is not modified by NEDD8 and not associated with Skp1

Oshikawa, K., Matsumoto, M., Yada, M., Kamura, T., Hatakeyama, S. & Nakayama, K. I., Apr 18 2003, In : Biochemical and Biophysical Research Communications. 303, 4, p. 1209-1216 8 p.

Research output: Contribution to journalArticle

F-Box Proteins
TATA-Box Binding Protein
Ubiquitin-Protein Ligases
Ligases
Ubiquitin
2002
19 Citations (Scopus)

Association study of polymorphisms in the GluR6 kainate receptor gene (GRIK2) with schizophrenia

Shibata, H., Shibata, A., Ninomiya, H., Tashiro, N. & Fukumaki, Y., Dec 15 2002, In : Psychiatry research. 113, 1-2, p. 59-67 9 p.

Research output: Contribution to journalArticle

Schizophrenia
Single Nucleotide Polymorphism
Genes
Haplotypes
Linkage Disequilibrium
19 Citations (Scopus)

Polymorphism analysis of the upstream region of the human N-methyl-D-aspartate receptor subunit NR1 gene (GRIN1): Implications for schizophrenia

Tani, A., Kikuta, R., Itoh, K., Joo, A., Shibata, H., Ninomiya, H., Tashiro, N. & Fukumaki, Y., Nov 1 2002, In : Schizophrenia research. 58, 1, p. 83-86 4 p.

Research output: Contribution to journalArticle

N-Methyl-D-Aspartate Receptors
Schizophrenia
Single Nucleotide Polymorphism
Genes
Initiator Codon
2001
71 Citations (Scopus)

Association analysis of polymorphisms in the upstream region of the human dopamine D4 receptor gene (DRD4) with schizophrenia and personality traits

Mitsuyasu, H., Hirata, N., Sakai, Y., Shibata, H., Takeda, Y., Ninomiya, H., Kawasaki, H., Tashiro, N. & Fukumaki, Y., Mar 10 2001, In : Journal of Human Genetics. 46, 1, p. 26-31 6 p.

Research output: Contribution to journalArticle

Dopamine D4 Receptors
Personality
Schizophrenia
Exons
Genes
30 Citations (Scopus)

Association study of polymorphisms in the GluR5 kainate receptor gene (GRIK1) with schizophrenia

Shibata, H., Joo, A., Fujii, Y., Tani, A., Makino, C., Hirata, N., Kikuta, R., Ninomiya, H., Tashiro, N. & Fukumaki, Y., Oct 30 2001, In : Psychiatric Genetics. 11, 3, p. 139-144 6 p.

Research output: Contribution to journalArticle

Single Nucleotide Polymorphism
Schizophrenia
Genes
Haplotypes
Polymerase Chain Reaction
151 Citations (Scopus)

Phenotypic modulation of vascular smooth muscle cells induced by unsaturated lysophosphatidic acids

Hayashi, K., Takahashi, M., Nishida, W., Yoshida, K., Ohkawa, Y., Kitabatake, A., Aoki, J., Arai, H. & Sobue, K., Aug 3 2001, In : Circulation research. 89, 3, p. 251-258 8 p.

Research output: Contribution to journalArticle

Lysophospholipids
Vascular Smooth Muscle
Smooth Muscle Myocytes
Cell Dedifferentiation
Atherosclerosis
43 Citations (Scopus)

Structure and polymorphisms of the human metabotropic glutamate receptor type 2 gene (GRM2): Analysis of association with schizophrenia

Joo, A., Shibata, H., Ninomiya, H., Kawasaki, H., Tashiro, N. & Fukumaki, Y., Mar 14 2001, In : Molecular Psychiatry. 6, 2, p. 186-192 7 p.

Research output: Contribution to journalArticle

Schizophrenia
Genes
Exons
eglumetad
Radiation Hybrid Mapping
26 Citations (Scopus)

The occurrence of geometric polyprenol isomers in the rubber- producing plant, Eucommia ulmoides oliver

Bamba, T., Fukusaki, E. I., Kajivama, S. I., Ute, K., Kitayama, T. & Kobayashi, A., Jan 1 2001, In : Lipids. 36, 7, p. 727-732 6 p.

Research output: Contribution to journalArticle

Eucommiaceae
Rubber
Isomers
Seed
Isomerism
2000
42 Citations (Scopus)

Cell cycle-dependent expression of mammalian E2-C regulated by the anaphase-promoting complex/cyclosome

Yamanaka, A., Hatakeyama, S., Kominami, K. I., Kitagawa, M., Matsumoto, M. & Nakayama, K. I., Jan 1 2000, In : Molecular biology of the cell. 11, 8, p. 2821-2831 11 p.

Research output: Contribution to journalArticle

Anaphase-Promoting Complex-Cyclosome
Cell Division
Cell Cycle
Ubiquitins
Polyubiquitin

Erratum: A novel protein with RNA-binding motifs interacts with ataxin-2 (Human Molecular Genetics (2000) vol.9 (1303-1313))

Shibata, H., Huynh, D. P. & Pulst, S. M., Aug 17 2000, In : Human Molecular Genetics. 9, 12, 1 p.

Research output: Contribution to journalComment/debate

Medical Genetics
Molecular Biology
Proteins
Ataxin-2
RNA-Binding Motifs
3 Citations (Scopus)

High pressure sensitizes murine erythroleukemia cells to caffeine-induced premature mitosis

Matsumoto, M., Yamaguchi, T., Nakazono, K., Fukumaki, Y. & Terada, S., Jan 1 2000, In : Japanese Journal of Physiology. 50, 3, p. 329-336 8 p.

Research output: Contribution to journalArticle

Leukemia, Erythroblastic, Acute
Caffeine
Mitosis
Aphidicolin
Pressure
12 Citations (Scopus)

Molecular analysis of α-thalassemia in Nepal: Correlation with malaria endemicity

Sakai, Y., Kobayashi, S., Shibata, H., Furuumi, H., Endo, T., Fucharoen, S., Hamano, S., Acharya, G. P., Kawasaki, T. & Fukumaki, Y., Jan 1 2000, In : Journal of Human Genetics. 45, 3, p. 127-132 6 p.

Research output: Contribution to journalArticle

Nepal
Thalassemia
Malaria
Globins
Mitochondrial DNA
591 Citations (Scopus)

Targeted disruption of Skp2 results in accumulation of cyclin E and p27 (Kip1), polyploidy and centrosome overduplication

Nakayama, K., Nagahama, H., Minamishima, Y. A., Matsumoto, M., Nakamichi, I., Kitagawa, K., Shirane, M., Tsunematsu, R., Tsukiyama, T., Ishida, N., Kitagawa, M., Nakayama, K. I. & Hatakeyama, S., May 2 2000, In : EMBO Journal. 19, 9, p. 2069-2081 13 p.

Research output: Contribution to journalArticle

Cyclin E
Centrosome
Polyploidy
SKP Cullin F-Box Protein Ligases
Ubiquitin
41 Citations (Scopus)

The ortholog of human ataxin-2 is essential for early embryonic patterning in C. elegans

Kiehl, T. R., Shibata, H. & Pulst, S. M., Jan 1 2000, In : Journal of Molecular Neuroscience. 15, 3, p. 231-241 11 p.

Research output: Contribution to journalArticle

Carrier Proteins
Caenorhabditis elegans
RNA Interference
Embryonic Development
Embryonic Structures
1999
445 Citations (Scopus)

An F-box protein, FWD1, mediates ubiquitin-dependent proteolysis of β-catenin

Kitagawa, M., Hatakeyama, S., Shirane, M., Matsumoto, M., Ishida, N., Hattori, K., Nakamichi, I., Kikuchi, A., Nakayama, K. I. & Nakayama, K., May 4 1999, In : EMBO Journal. 18, 9, p. 2401-2410 10 p.

Research output: Contribution to journalArticle

F-Box Proteins
Proteolysis
Catenins
Ubiquitin
Ubiquitination
34 Citations (Scopus)

Molecular dissection of the interactions among IκBα, FWD1, and Skp1 required for ubiquitin-mediated proteolysis of IκBα

Hattori, K., Hatakeyama, S., Shirane, M., Matsumoto, M. & Nakayama, K. I., Oct 15 1999, In : Journal of Biological Chemistry. 274, 42, p. 29641-29647 7 p.

Research output: Contribution to journalArticle

Proteolysis
Dissection
Phosphorylation
Ubiquitination
Ubiquitin
168 Citations (Scopus)

Ubiquitin-dependent degradation of IκBα is mediated by a ubiquitin ligase Skp1/Cul 1/F-box protein FWD1

Hatakeyama, S., Kitagawa, M., Nakayama, K., Shirane, M., Matsumoto, M., Hattori, K., Higashi, H., Nakano, H., Okumura, K., Onoé, K., Good, R. A. & Nakayama, K. I., Mar 30 1999, In : Proceedings of the National Academy of Sciences of the United States of America. 96, 7, p. 3859-3863 5 p.

Research output: Contribution to journalArticle

F-Box Proteins
Ubiquitination
Ligases
Ubiquitin
SKP Cullin F-Box Protein Ligases
1996
5 Citations (Scopus)

Effects of intracellular pH on high pressure-induced hemolysis of anion transport inhibitor-treated erythrocytes

Matsumoto, M., Yamaguchi, T., Terada, S. & Kimoto, E., Apr 26 1996, In : Biochimica et Biophysica Acta - Biomembranes. 1280, 2, p. 243-250 8 p.

Research output: Contribution to journalArticle

Hemolysis
Anions
Erythrocytes
Diamide
Pressure
11 Citations (Scopus)

Molecular evolution of the 5′-flanking regions of the duplicated Amy genes in Drosophila melanogaster species subgroup

Okuyama, E., Shibata, H., Tachida, H. & Yamazaki, T., Apr 1996, In : Molecular Biology and Evolution. 13, 4, p. 574-583 10 p.

Research output: Contribution to journalArticle

Molecular Evolution
5' Flanking Region
Drosophila melanogaster
gene
divergence
1995
17 Citations (Scopus)

Effects of anion transport inhibitors on hemolysis of human erythrocytes under hydrostatic pressure

Yamaguchi, T., Matsumoto, M. & Kimoto, E., Oct 1995, In : Journal of biochemistry. 118, 4, p. 760-764 5 p.

Research output: Contribution to journalArticle

Hydrostatic Pressure
Hydrostatic pressure
Hemolysis
Anions
Erythrocytes
42 Citations (Scopus)

Evolutionary relationships and sequence variation of α-amylase variants encoded by duplicated genes in the Amy locus of Drosophila melanogaster

Inomata, N., Shibata, H., Okuyama, E. & Yamazaki, T., Jan 1 1995, In : Genetics. 141, 1, p. 237-244 8 p.

Research output: Contribution to journalArticle

Amino Acid Substitution
Amylases
Drosophila melanogaster
Genetic Recombination
Gene Conversion
64 Citations (Scopus)
3' Flanking Region
Gene Duplication
Molecular Evolution
5' Flanking Region
Drosophila melanogaster
10 Citations (Scopus)

RNA-primed PCR

Shibata, H., Tahira, T. & Hayashi, K., Nov 1 1995, In : Genome Research. 5, 4, p. 400-403 4 p.

Research output: Contribution to journalArticle

RNA
Polymerase Chain Reaction
DNA Primers
RNA-Directed DNA Polymerase
DNA-Directed DNA Polymerase
1994
12 Citations (Scopus)

A comparative study of the enzymologieal features of α-amylase in the Drosophila melanogaster species subgroup

Shibata, H. & Yamazaki, T., Jan 1 1994, In : Japanese Journal of Genetics. 69, 3, p. 251-258 8 p.

Research output: Contribution to journalArticle

Amylases
Drosophila melanogaster
Temperature
Phylogeny
Enzymes