Research Institute for Deseases of the Chest

Research Output

2020

Inhibition of PI3Kδ Enhances Poly I:C-Induced Antiviral Responses and Inhibits Replication of Human Metapneumovirus in Murine Lungs and Human Bronchial Epithelial Cells

Fujita, A., Kan-o, K., Tonai, K., Yamamoto, N., Ogawa, T., Fukuyama, S., Nakanishi, Y. & Matsumoto, K., Mar 11 2020, In : Frontiers in Immunology. 11, 432.

Research output: Contribution to journalArticle

Open Access
2019

A Clinicopathological and Prognostic Analysis of PD-L2 Expression in Surgically Resected Primary Lung Squamous Cell Carcinoma

Matsubara, T., Takada, K., Azuma, K., Takamori, S., Toyokawa, G., Haro, A., Osoegawa, A., Tagawa, T., Kawahara, A., Akiba, J., Okamoto, I., Nakanishi, Y., Oda, Y., Hoshino, T. & Maehara, Y., Jun 15 2019, In : Annals of Surgical Oncology. 26, 6, p. 1925-1933 9 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Effects of cigarette smoke on barrier function and tight junction proteins in the bronchial epithelium: Protective role of cathelicidin LL-37

Tatsuta, M., Kan-O, K., Ishii, Y., Yamamoto, N., Ogawa, T., Fukuyama, S., Ogawa, A., Fujita, A., Nakanishi, Y. & Matsumoto, K., Nov 9 2019, In : Respiratory Research. 20, 1, 251.

Research output: Contribution to journalArticle

Open Access
4 Citations (Scopus)

Identification of genomic alterations acquired during treatment with EGFR-TKIs in non-small cell lung cancer

Kubo, N., Harada, T., Shiraishi, Y., Nosaki, K., Nakagaki, N., Takeshita, M., Ouchi, H., Iwama, E., Tanaka, K., Okamoto, I., Sasaki, H. & Nakanishi, Y., Feb 2019, In : Anticancer research. 39, 2, p. 671-677 7 p.

Research output: Contribution to journalArticle

Meteorological effects on severe hemoptysis: A hospital-based observational study

Ogata, H., Matsumoto, K., Shinozaki, S., Hasegawa, M., Nakamura, S., Mizusaki, S., Takao, T., Nakatomi, K., Nakashima, N., Takahashi, K., Soeda, H., Hanada, K. & Koto, H., Jul 2019, In : Respiratory Investigation. 57, 4, p. 361-367 7 p.

Research output: Contribution to journalArticle

Periodontitis Is Associated with Chronic Obstructive Pulmonary Disease

Takeuchi, K., Matsumoto, K., Furuta, M., Fukuyama, S., Takeshita, T., Ogata, H., Suma, S., Shibata, Y., Shimazaki, Y., Hata, J., Ninomiya, T., Nakanishi, Y., Inoue, H. & Yamashita, Y., May 1 2019, In : Journal of Dental Research. 98, 5, p. 534-540 7 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Prognostic Impact of Programmed Death-Ligand 2 Expression in Primary Lung Adenocarcinoma Patients

Takamori, S., Takada, K., Azuma, K., Jogo, T., Shimokawa, M., Toyokawa, G., Hirai, F., Tagawa, T., Kawahara, A., Akiba, J., Okamoto, I., Nakanishi, Y., Oda, Y., Hoshino, T. & Maehara, Y., Jun 15 2019, In : Annals of Surgical Oncology. 26, 6, p. 1916-1924 9 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Safety and efficacy of PD-1 inhibitors in non–small cell lung cancer patients positive for antinuclear antibodies

Yoneshima, Y., Tanaka, K., Shiraishi, Y., Hata, K., Watanabe, H., Harada, T., Otsubo, K., Iwama, E., Inoue, H., Masuda, S., Nakanishi, Y. & Okamoto, I., Apr 2019, In : Lung Cancer. 130, p. 5-9 5 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)
Open Access
2018

Academia–industry Cooperation in the Medical Field: Matching Opportunities in Japan

Tsuruya, N., Kawashima, T., Shiozuka, M., Nakanishi, Y. & Sugiyama, D., Nov 2018, In : Clinical Therapeutics. 40, 11, p. 1807-1812 6 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

An autopsy case of bird-related chronic hypersensitivity pneumonitis presenting with repeated acute exacerbation

Mikumo, H., Yanagihara, T., Hamada, N., Hashisako, M., Ijichi, K., Suzuki, K., Harada, E., Shikada, Y., Oda, Y. & Nakanishi, Y., Jan 1 2018, In : Respiratory Medicine Case Reports. 24, p. 92-94 3 p.

Research output: Contribution to journalArticle

A novel combination therapy for human oxaliplatin-resistant colorectal cancer using oxaliplatin and coxsackievirus A11

Wang, B., Ogata, H., Takishima, Y., Miyamoto, S., Inoue, H., Kuroda, M., Yamada, K., Hijikata, Y., Murahashi, M., Shimizu, H., Okazaki, T., Nakanishi, Y. & Tani, K., Nov 2018, In : Anticancer research. 38, 11, p. 6121-6126 6 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Anticancer drug treatment for advanced lung cancer with interstitial lung disease

Otsubo, K., Okamoto, I., Hamada, N. & Nakanishi, Y., Jul 2018, In : Respiratory Investigation. 56, 4, p. 307-311 5 p.

Research output: Contribution to journalReview article

5 Citations (Scopus)

A phase I clinical trial of RNF43 peptide-related immune cell therapy combined with low-dose cyclophosphamide in patients with advanced solid tumors

Hijikata, Y., Okazaki, T., Tanaka, Y., Murahashi, M., Yamada, Y., Yamada, K., Takahashi, A., Inoue, H., Kishimoto, J., Nakanishi, Y., Oda, Y., Nakamura, Y. & Tani, K., Jan 2018, In : PloS one. 13, 1, e0187878.

Research output: Contribution to journalArticle

4 Citations (Scopus)

A randomised phase II trial of S-1 plus cisplatin versus vinorelbine plus cisplatin with concurrent thoracic radiotherapy for unresectable, locally advanced non-small cell lung cancer: WJOG5008L

Sasaki, T., Seto, T., Yamanaka, T., Kunitake, N., Shimizu, J., Kodaira, T., Nishio, M., Kozuka, T., Takahashi, T., Harada, H., Yoshimura, N., Tsutsumi, S., Kitajima, H., Kataoka, M., Ichinose, Y., Nakagawa, K., Nishimura, Y., Yamamoto, N. & Nakanishi, Y., Sep 11 2018, In : British journal of cancer. 119, 6, p. 675-682 8 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Association of nephrotoxicity during platinum-etoposide doublet therapy with UGT1A1 polymorphisms in small cell lung cancer patients

Anai, S., Iwama, E., Yoneshima, Y., Otsubo, K., Tanaka, K., Nakanishi, Y. & Okamoto, I., Dec 2018, In : Lung Cancer. 126, p. 156-161 6 p.

Research output: Contribution to journalArticle

Association of preoperative serum CRP with PD-L1 expression in 508 patients with non-small cell lung cancer: A comprehensive analysis of systemic inflammatory markers

Akamine, T., Takada, K., Toyokawa, G., Kinoshita, F., Matsubara, T., Kozuma, Y., Haratake, N., Takamori, S., Hirai, F., Tagawa, T., Okamoto, T., Yoneshima, Y., Okamoto, I., Shimokawa, M., Oda, Y., Nakanishi, Y. & Maehara, Y., Mar 2018, In : Surgical Oncology. 27, 1, p. 88-94 7 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Clinical significance of PD-L1 expression in brain metastases from non-small cell lung cancer

Takamori, S., Toyokawa, G., Okamoto, I., Takada, K., Kinoshita, F., Kozuma, Y., Matsubara, T., Haratake, N., Akamine, T., Mukae, N., Hirai, F., Tagawa, T., Oda, Y., Iwaki, T., Iihara, K., Nakanishi, Y. & Maehara, Y., Jan 2018, In : Anticancer research. 38, 1, p. 553-557 5 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Combined therapy with epidermal growth factor receptor tyrosine kinase inhibitors for non–small cell lung cancer

Iwama, E., Nakanishi, Y. & Okamoto, I., Mar 4 2018, In : Expert Review of Anticancer Therapy. 18, 3, p. 267-276 10 p.

Research output: Contribution to journalReview article

6 Citations (Scopus)

Detection of identical T cell clones in peritumoral pleural effusion and pneumonitis lesions in a cancer patient during immune-checkpoint blockade

Tanaka, K., Yanagihara, T., Ikematsu, Y., Inoue, H., Ota, K., Kashiwagi, E., Suzuki, K., Hamada, N., Takeuchi, A., Tatsugami, K., Eto, M., Ijichi, K., Oda, Y., Otsubo, K., Yoneshima, Y., Iwama, E., Nakanishi, Y. & Okamoto, I., Jul 17 2018, In : Oncotarget. 9, 55, p. 30587-30593 7 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Development of leptomeningeal carcinomatosis during a marked response of brain metastases to pembrolizumab in a patient with non-small-cell lung cancer

Otsubo, K., Seki, N., Nakanishi, Y. & Okamoto, I., Mar 1 2018, In : Annals of Oncology. 29, 3, p. 780-781 2 p.

Research output: Contribution to journalLetter

1 Citation (Scopus)

Durable response to nivolumab in a lung adenocarcinoma patient with idiopathic pulmonary fibrosis

Ide, M., Tanaka, K., Sunami, S., Asoh, T., Maeyama, T., Tsuruta, N., Nakanishi, Y. & Okamoto, I., Nov 2018, In : Thoracic Cancer. 9, 11, p. 1519-1521 3 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Exploration of resistance mechanisms for epidermal growth factor receptor-tyrosine kinase inhibitors based on plasma analysis by digital polymerase chain reaction and next-generation sequencing

Iwama, E., Sakai, K., Azuma, K., Harada, D., Nosaki, K., Hotta, K., Nishio, M., Kurata, T., Fukuhara, T., Akamatsu, H., Goto, K., Shimose, T., Kishimoto, J., Nakanishi, Y., Nishio, K. & Okamoto, I., Dec 2018, In : Cancer Science. 109, 12, p. 3921-3933 13 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Expression of brain-derived neurotrophic factor and its receptor TrkB is associated with poor prognosis and a malignant phenotype in small cell lung cancer

Kimura, S., Harada, T., Ijichi, K., Tanaka, K., Liu, R., Shibahara, D., Kawano, Y., Otsubo, K., Yoneshima, Y., Iwama, E., Nakanishi, Y. & Okamoto, I., Jun 2018, In : Lung Cancer. 120, p. 98-107 10 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Expression of PD-1 and PD-L1 on cytotoxic T lymphocytes and immune deficiency in a patient with adult T cell leukemia/lymphoma

Yanagihara, T., Ikematsu, Y., Kato, K., Yonekawa, A., Ideishi, S., Tochigi, T., Sugio, T., Miyawaki, K., Tanaka, K., Harada, E., Hamada, N. & Nakanishi, Y., Feb 1 2018, In : Annals of Hematology. 97, 2, p. 359-360 2 p.

Research output: Contribution to journalLetter

1 Citation (Scopus)

Frequency-dependent airway hyperresponsiveness in a mouse model of emphysema and allergic inflammation

Tamura, K., Matsumoto, K., Fukuyama, S., Kan-o, K., Ishii, Y., Tonai, K., Tatsuta, M., Enokizu, A., Inoue, H. & Nakanishi, Y., Jan 2018, In : Physiological Reports. 6, 2, e13568.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Intellectual Property in the Field of Regenerative Medicine in Japan

Asano, S., Nakanishi, Y. & Sugiyama, D., Nov 2018, In : Clinical Therapeutics. 40, 11, p. 1823-1827 5 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Interstitial pneumonia caused by dabigatran

Yanagihara, T., Yamamoto, N., Kotetsu, Y., Hamada, N., Harada, E., Suzuki, K., Ijichi, K., Oda, Y. & Nakanishi, Y., Jan 1 2018, In : Respiratory Medicine Case Reports. 23, p. 10-12 3 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Intrinsic and Extrinsic Regulation of PD-L2 Expression in Oncogene-Driven Non–Small Cell Lung Cancer

Shibahara, D., Tanaka, K., Iwama, E., Kubo, N., Ota, K., Azuma, K., Harada, T., Fujita, J., Nakanishi, Y. & Okamoto, I., Jul 2018, In : Journal of Thoracic Oncology. 13, 7, p. 926-937 12 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Investigator initiated clinical trial of cancer vaccine OCV-C01 in advanced and recurrent biliary tract cancer

Murahashi, M., Ogata, H., Okazaki, T., Hijikata, Y., Yamada, K., Tsuruta, T., Kishimoto, J., Funakoshi, K., Todaka, K., Nakanishi, Y. & Tani, K., Oct 2018, In : Annals of oncology : official journal of the European Society for Medical Oncology. 29 Suppl 7, p. vii60

Research output: Contribution to journalArticle

PD-L1 expression in lung adenocarcinoma harboring EGFR mutations or ALK rearrangements

Yoneshima, Y., Ijichi, K., Anai, S., Ota, K., Otsubo, K., Iwama, E., Tanaka, K., Oda, Y., Nakanishi, Y. & Okamoto, I., Apr 2018, In : Lung Cancer. 118, p. 36-40 5 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)

PD-L2 expression as a potential predictive biomarker for the response to anti-PD-1 drugs in patients with non-small cell lung cancer

Takamori, S., Takada, K., Toyokawa, G., Azuma, K., Shimokawa, M., Jogo, T., Yamada, Y., Hirai, F., Tagawa, T., Kawahara, A., Akiba, J., Okamoto, I., Nakanishi, Y., Oda, Y., Hoshino, T. & Maehara, Y., Oct 2018, In : Anticancer research. 38, 10, p. 5897-5901 5 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Periodontal status and lung function decline in the community: the Hisayama study

Takeuchi, K., Matsumoto, K., Furuta, M., Fukuyama, S., Takeshita, T., Ogata, H., Suma, S., Shibata, Y., Shimazaki, Y., Hata, J., Ninomiya, T., Nakanishi, Y., Inoue, H. & Yamashita, Y., Dec 1 2018, In : Scientific reports. 8, 1, 13354.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Phase I/II study of carboplatin plus nab-paclitaxel and concurrent radiotherapy for patients with locally advanced non–small cell lung cancer

Kawano, Y., Sasaki, T., Yamaguchi, H., Hirano, K., Horiike, A., Satouchi, M., Hosokawa, S., Morinaga, R., Komiya, K., Inoue, K., Fujita, Y., Toyozawa, R., Kimura, T., Takahashi, K., Nishikawa, K., Kishimoto, J., Nakanishi, Y. & Okamoto, I., Nov 2018, In : Lung Cancer. 125, p. 136-141 6 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Preclinical Toxicity Studies for Regenerative Medicine in Japan

Shigeto, J., Ichiki, T., Nii, T., Konno, K., Nakanishi, Y. & Sugiyama, D., Nov 2018, In : Clinical Therapeutics. 40, 11, p. 1813-1822 10 p.

Research output: Contribution to journalReview article

2 Citations (Scopus)

Prevalence of Delta-like protein 3 expression in patients with small cell lung cancer

Tanaka, K., Isse, K., Fujihira, T., Takenoyama, M., Saunders, L., Bheddah, S., Nakanishi, Y. & Okamoto, I., Jan 2018, In : Lung Cancer. 115, p. 116-120 5 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)

Prognostic impact of PD-L2 expression and association with PD-L1 in patients with small-cell lung cancer

Takamori, S., Takada, K., Azuma, K., Jogo, Y., Kinoshita, F., Kozuma, Y., Matsubara, T., Haratake, N., Akamine, T., Toyokawa, G., Hirai, F., Tagawa, T., Okamoto, I., Nakanishi, Y., Kawahara, A., Akiba, J., Oda, Y. & Maehara, Y., Oct 2018, In : Anticancer research. 38, 10, p. 5903-5907 5 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Purification of zebrafish erythrocytes as a means of identifying a novel regulator of haematopoiesis

Kulkeaw, K., Inoue, T., Ishitani, T., Nakanishi, Y., Zon, L. I. & Sugiyama, D., Feb 1 2018, In : British Journal of Haematology. 180, 3, p. 420-431 12 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Radiological features of programmed cell death-ligand 2-positive lung adenocarcinoma: A single-institution retrospective study

Takada, K., Toyokawa, G., Azuma, K., Takamori, S., Jogo, T., Hirai, F., Tagawa, T., Kawahara, A., Akiba, J., Okamoto, I., Nakanishi, Y., Oda, Y., Hoshino, T. & Maehara, Y., Nov 1 2018, In : In Vivo. 32, 6, p. 1541-1550 10 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Recurrent idiopathic pulmonary hemosiderosis after long-term remission presented with Sjogren's syndrome: Idiopathic no more?

Yanagihara, T., Yamamoto, Y., Hamada, N., Suzuki, K., Ogata-Suetsugu, S., Harada, E., Tagawa, T., Fujiwara, M., Hashisako, M., Fukuoka, J. & Nakanishi, Y., Jan 1 2018, In : Respiratory Medicine Case Reports. 25, p. 68-72 5 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Regulation of Pathogenic T Helper 17 Cell Differentiation by Steroid Receptor Coactivator-3

Tanaka, K., Martinez, G. J., Yan, X., Long, W., Ichiyama, K., Chi, X., Kim, B. S., Reynolds, J. M., Chung, Y., Tanaka, S., Liao, L., Nakanishi, Y., Yoshimura, A., Zheng, P., Wang, X., Tian, Q., Xu, J., O'Malley, B. W. & Dong, C., May 22 2018, In : Cell Reports. 23, 8, p. 2318-2329 12 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Seasonal and meteorological impacts on primary spontaneous pneumothorax

Ogata, H., Matsumoto, K., Nakatomi, K., Nakashima, N., Shoji, F. & Koto, H., Jul 1 2018, In : Journal of Thoracic Disease. 10, 7, p. 3957-3964 8 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Sensitivity of epidermal growth factor receptor with single or double uncommon mutations to afatinib confirmed by a visual assay

Kimura, S., Tanaka, K., Harada, T., Liu, R., Shibahara, D., Kawano, Y., Nakanishi, Y. & Okamoto, I., Nov 2018, In : Cancer Science. 109, 11, p. 3657-3661 5 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Treatment Rationale and Design for J-SONIC: A Randomized Study of Carboplatin Plus Nab-paclitaxel With or Without Nintedanib for Advanced Non–Small-cell Lung Cancer With Idiopathic Pulmonary Fibrosis

Otsubo, K., Kishimoto, J., Kenmotsu, H., Minegishi, Y., Ichihara, E., Shiraki, A., Kato, T., Atagi, S., Horinouchi, H., Ando, M., Kondoh, Y., Kusumoto, M., Ichikado, K., Yamamoto, N., Nakanishi, Y. & Okamoto, I., Jan 2018, In : Clinical Lung Cancer. 19, 1, p. e5-e9

Research output: Contribution to journalArticle

22 Citations (Scopus)
2017

A case of immunoglobulin G4-related respiratory disease with multiple lung cysts: A case report

Mikumo, H., Hamada, N., Harada, E., Yanagihara, T., Ogata, S., Yabuuchi, H., Ijichi, K., Takayama, K. & Nakanishi, Y., Jan 1 2017, In : Respiratory Medicine Case Reports. 21, p. 89-92 4 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Alectinib for Patients with ALK Rearrangement–Positive Non–Small Cell Lung Cancer and a Poor Performance Status (Lung Oncology Group in Kyushu 1401)

Iwama, E., Goto, Y., Murakami, H., Harada, T., Tsumura, S., Sakashita, H., Mori, Y., Nakagaki, N., Fujita, Y., Seike, M., Bessho, A., Ono, M., Okazaki, A., Akamatsu, H., Morinaga, R., Ushijima, S., Shimose, T., Tokunaga, S., Hamada, A., Yamamoto, N. & 3 others, Nakanishi, Y., Sugio, K. & Okamoto, I., Jul 2017, In : Journal of Thoracic Oncology. 12, 7, p. 1161-1166 6 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Amphiregulin suppresses epithelial cell apoptosis in lipopolysaccharide-induced lung injury in mice

Ogata-Suetsugu, S., Yanagihara, T., Hamada, N., Ikeda-Harada, C., Yokoyama, T., Suzuki, K., Kawaguchi, T., Maeyama, T. & Nakanishi, Y., Mar 4 2017, In : Biochemical and Biophysical Research Communications. 484, 2, p. 422-428 7 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)
6 Citations (Scopus)

Association of airflow limitation with carotid atherosclerosis in a japanese community ― the hisayama study

Kudo, K., Hata, J., Matsumoto, K., Shundo, Y., Fukuyama, S., Inoue, H., Kitazono, T., Kiyohara, Y., Ninomiya, T. & Nakanishi, Y., Jan 1 2017, In : Circulation Journal. 81, 12, p. 1846-1853 8 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Azithromycin attenuates myofibroblast differentiation and lung fibrosis development through proteasomal degradation of NOX4

Tsubouchi, K., Araya, J., Minagawa, S., Hara, H., Ichikawa, A., Saito, N., Kadota, T., Sato, N., Yoshida, M., Kurita, Y., Kobayashi, K., Ito, S., Fujita, Y., Utsumi, H., Yanagisawa, H., Hashimoto, M., Wakui, H., Yoshii, Y., Ishikawa, T., Numata, T. & 8 others, Kaneko, Y., Asano, H., Yamashita, M., Odaka, M., Morikawa, T., Nakayama, K., Nakanishi, Y. & Kuwano, K., Aug 3 2017, In : Autophagy. 13, 8, p. 1420-1434 15 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)