Researth and Development of Next Generation Medicine

Research Output 2006 2018

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2018
4 Citations (Scopus)

A phase I clinical trial of RNF43 peptide-related immune cell therapy combined with low-dose cyclophosphamide in patients with advanced solid tumors

Hijikata, Y., Okazaki, T., Tanaka, Y., Murahashi, M., Yamada, Y., Yamada, K., Takahashi, A., Inoue, H., Kishimoto, J., Nakanishi, Y., Oda, Y., Nakamura, Y. & Tani, K., Jan 2018, In : PloS one. 13, 1, e0187878.

Research output: Contribution to journalArticle

Clinical Trials, Phase I
cyclophosphamide
Cell- and Tissue-Based Therapy
Cyclophosphamide
Fingers

Growth suppression of human colorectal cancer cells with mutated KRAS by 3-deaza-cytarabine in 3d floating culture

Luo, H., Nishi, K., Ishikura, S., Swain, A., Morishige, N., Yazaki, R., Ohshima, T., Shirasawa, S. & Tsunoda, T., Jul 1 2018, In : Anticancer research. 38, 7, p. 4247-4256 10 p.

Research output: Contribution to journalArticle

Cytarabine
Colorectal Neoplasms
Uridine
Growth
gemcitabine
1 Citation (Scopus)

Purification of zebrafish erythrocytes as a means of identifying a novel regulator of haematopoiesis

Kulkeaw, K., Inoue, T., Ishitani, T., Nakanishi, Y., Zon, L. I. & Sugiyama, D., Feb 1 2018, In : British Journal of Haematology. 180, 3, p. 420-431 12 p.

Research output: Contribution to journalArticle

Hematopoiesis
Zebrafish
Erythrocytes
Embryonic Structures
Globins
3 Citations (Scopus)
Intravenous Administration
Nanoparticles
Pharmacokinetics
Placebos
Research Personnel
17 Citations (Scopus)

Treatment Rationale and Design for J-SONIC: A Randomized Study of Carboplatin Plus Nab-paclitaxel With or Without Nintedanib for Advanced Non–Small-cell Lung Cancer With Idiopathic Pulmonary Fibrosis

Otsubo, K., Kishimoto, J., Kenmotsu, H., Minegishi, Y., Ichihara, E., Shiraki, A., Kato, T., Atagi, S., Horinouchi, H., Ando, M., Kondoh, Y., Kusumoto, M., Ichikado, K., Yamamoto, N., Nakanishi, Y. & Okamoto, I., Jan 2018, In : Clinical Lung Cancer. 19, 1, p. e5-e9

Research output: Contribution to journalArticle

Idiopathic Pulmonary Fibrosis
Carboplatin
Non-Small Cell Lung Carcinoma
Nanoparticles
Therapeutics
2017
1 Citation (Scopus)

A Transcriptional Switch Point during Hematopoietic Stem and Progenitor Cell Ontogeny

Sugiyama, D., Joshi, A., Kulkeaw, K., Tan, K. S., Yokoo-Inoue, T., Mizuochi-Yanagi, C., Yasuda, K., Doi, A., Iino, T., Itoh, M., Nagao-Sato, S., Tani, K., Akashi, K., Hayashizaki, Y., Suzuki, H., Kawaji, H., Carninci, P. & Forrest, A. R. R., Mar 1 2017, In : Stem cells and development. 26, 5, p. 314-327 14 p.

Research output: Contribution to journalArticle

Hematopoietic Stem Cells
Mesonephros
Gonads
Aorta
Placenta
3 Citations (Scopus)

A unique microenvironment in the developing liver supports the expansion of megakaryocyte progenitors

Brouard, N., Jost, C., Matthias, N., Albrecht, C., Egard, S., Gandhi, P., Strassel, C., Inoue, T., Sugiyama, D., Simmons, P. J., Gachet, C. & Lanza, F., Sep 26 2017, In : Blood Advances. 1, 21, p. 1854-1866 13 p.

Research output: Contribution to journalArticle

Open Access
Megakaryocyte Progenitor Cells
Hematopoietic Stem Cells
Megakaryocytes
Liver
Stromal Cells
1 Citation (Scopus)

Clarithromycin plus intravenous immunoglobulin therapy can reduce the relapse rate of Kawasaki disease: A phase 2, open-label, randomized control study

Nanishi, E., Nishio, H., Takada, H., Yamamura, K., Fukazawa, M., Furuno, K., Mizuno, Y., Saigo, K., Kadoya, R., Ohbuchi, N., Onoe, Y., Yamashita, H., Nakayama, H., Hara, T., Ohno, T., Takahashi, Y., Hatae, K., Harada, T., Shimose, T., Kishimoto, J. & 2 others, Ohga, S. & Hara, T., Jul 1 2017, In : Journal of the American Heart Association. 6, 7, e005370.

Research output: Contribution to journalArticle

Mucocutaneous Lymph Node Syndrome
Passive Immunization
Clarithromycin
Intravenous Immunoglobulins
Recurrence
2 Citations (Scopus)

Early tumor shrinkage indicates a favorable response to bevacizumab-based first-line chemotherapy for metastatic colorectal cancer

Ito, M., Kusaba, H., Mukaide, S., Kishimoto, J., Shimokawa, H., Tamura, S., Makiyama, A., Hirano, G., Oda, H., Shirakawa, T., Komoda, M., Uchino, K., Tanaka, R., Mitsugi, K., Esaki, T., Arita, S., Ariyama, H., Akashi, K. & Baba, E., Jan 1 2017, In : Anti-cancer drugs. 28, 10, p. 1166-1173 8 p.

Research output: Contribution to journalArticle

Colorectal Neoplasms
Drug Therapy
Survival
Neoplasms
Growth Factor Receptors
4 Citations (Scopus)

Expression of cytokine and extracellular matrix mRNAs in fetal hepatic stellate cells

Tan, K. S., Kulkeaw, K., Nakanishi, Y. & Sugiyama, D., Sep 2017, In : Genes to Cells. 22, 9, p. 836-844 9 p.

Research output: Contribution to journalArticle

Hepatic Stellate Cells
Extracellular Matrix
Cytokines
Messenger RNA
Liver
11 Citations (Scopus)

Ezetimibe in combination with statins ameliorates endothelial dysfunction in coronary arteries after stenting: the CuVIC trial (effect of cholesterol absorption inhibitor usage on target vessel dysfunction after coronary stenting), a multicenter randomized controlled trial

Takase, S., Matoba, T., Nakashiro, S., Mukai, Y., Inoue, S., Oi, K., Higo, T., Katsuki, S., Takemoto, M., Suematsu, N., Eshima, K., Miyata, K., Yamamoto, M., Usui, M., Sadamatsu, K., Satoh, S., Kadokami, T., Hironaga, K., Ichi, I., Todaka, K. & 3 others, Kishimoto, J., Egashira, K. & Sunagawa, K., Feb 2017, In : Arteriosclerosis, thrombosis, and vascular biology. 37, 2, p. 350-358 9 p.

Research output: Contribution to journalArticle

Anticholesteremic Agents
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Coronary Vessels
Randomized Controlled Trials
Coronary Angiography
21 Citations (Scopus)

FANTOM5 CAGE profiles of human and mouse samples

Noguchi, S., Arakawa, T., Fukuda, S., Furuno, M., Hasegawa, A., Hori, F., Ishikawa-Kato, S., Kaida, K., Kaiho, A., Kanamori-Katayama, M., Kawashima, T., Kojima, M., Kubosaki, A., Manabe, R. I., Murata, M., Nagao-Sato, S., Nakazato, K., Ninomiya, N., Nishiyori-Sueki, H., Noma, S. & 158 others, Saijyo, E., Saka, A., Sakai, M., Simon, C., Suzuki, N., Tagami, M., Watanabe, S., Yoshida, S., Arner, P., Axton, R. A., Babina, M., Kenneth Baillie, J., Barnett, T. C., Beckhouse, A. G., Blumenthal, A., Bodega, B., Bonetti, A., Briggs, J., Brombacher, F., Carlisle, A. J., Clevers, H. C., Davis, C. A., Detmar, M., Dohi, T., Edge, B. A. S., Edinger, M., Ehrlund, A., Ekwall, K., Endoh, M., Enomoto, H., Eslami, A., Fagiolini, M., Fairbairn, L., Farach-Carson, M. C., Faulkner, G. J., Ferrai, C., Fisher, M. E., Forrester, L. M., Fujita, R., Furusawa, J. I., Geijtenbeek, T. B., Gingeras, T., Goldowitz, D., Guhl, S., Guler, R., Gustincich, S., Ha, T. J., Hamaguchi, M., Hara, M., Hasegawa, Y., Herlyn, M., Heutink, P., Hitchens, K. J., Hume, D. A., Ikawa, T., Ishizu, Y., Kai, C., Kawamoto, H., Kawamura, Y. I., Kempfle, J. S., Kenna, T. J., Kere, J., Khachigian, L. M., Kitamura, T., Klein, S., Peter Klinken, S., Knox, A. J., Kojima, S., Koseki, H., Koyasu, S., Lee, W., Lennartsson, A., MacKay-Sim, A., Mejhert, N., Mizuno, Y., Morikawa, H., Morimoto, M., Moro, K., Morris, K. J., Motohashi, H., Mummery, C. L., Nakachi, Y., Nakahara, F., Nakamura, T., Nakamura, Y., Nozaki, T., Ogishima, S., Ohkura, N., Ohno, H., Ohshima, M., Okada-Hatakeyama, M., Okazaki, Y., Orlando, V., Ovchinnikov, D. A., Passier, R., Patrikakis, M., Pombo, A., Pradhan-Bhatt, S., Qin, X. Y., Rehli, M., Rizzu, P., Roy, S., Sajantila, A., Sakaguchi, S., Sato, H., Satoh, H., Savvi, S., Saxena, A., Schmidl, C., Schneider, C., Schulze-Tanzil, G. G., Schwegmann, A., Sheng, G., Shin, J. W., Sugiyama, D., Sugiyama, T., Summers, K. M., Takahashi, N., Takai, J., Tanaka, H., Tatsukawa, H., Tomoiu, A., Toyoda, H., Wetering, M., Berg, L. M. V. D., Verardo, R., Vijayan, DI., Wells, C. A., Winteringham, L. N., Wolvetang, E., Yamaguchi, Y., Yamamoto, M., Yanagi-Mizuochi, C., Yoneda, M., Yonekura, Y., Zhang, P. G., Zucchelli, S., Abugessaisa, I., Arner, E., Harshbarger, J., Kondo, A., Lassmann, T., Lizio, M., Sahin, S., Sengstag, T., Severin, J., Shimoji, H., Suzuki, M., Suzuki, H., Kawai, J., Kondo, N., Itoh, M., Daub, C. O., Kasukawa, T., Kawaji, H., Carninci, P., Forrest, A. R. R. & Hayashizaki, Y., Aug 29 2017, In : Scientific Data. 4, 170112.

Research output: Contribution to journalArticle

Gene Expression Profile
Gene expression
Mouse
Transcription
Cell
1 Citation (Scopus)

Impact of Risk-Benefit Perception and Trust on Medical Technology Acceptance in Relation to Drug and Device Lag: A Tripartite Cross-Sectional Survey

Todaka, K., Kishimoto, J., Ikeda, M., Ikeda, K. & Yamamoto, H., Jan 1 2017, (Accepted/In press) In : Therapeutic Innovation and Regulatory Science. 52, 5, p. 629-640 12 p.

Research output: Contribution to journalArticle

Japan
Cross-Sectional Studies
Technology
Equipment and Supplies
Pharmaceutical Preparations
6 Citations (Scopus)

Induction of intrinsic apoptosis in leukaemia stem cells and in vivo zebrafish model by betulonic acid isolated from Walsura pinnata Hassk (Meliaceae)

Leong, K. H., Mahdzir, M. A., Din, M. F. M., Awang, K., Tanaka, Y., Kulkeaw, K., Ishitani, T. & Sugiyama, D., Mar 15 2017, In : Phytomedicine. 26, p. 11-21 11 p.

Research output: Contribution to journalArticle

Meliaceae
Zebrafish
Leukemia
Stem Cells
Apoptosis
1 Citation (Scopus)

Longitudinal assessment of pain management with the pain management index in cancer outpatients receiving chemotherapy

Fujii, A., Yamada, Y., Takayama, K., Nakano, T., Kishimoto, J., Morita, T. & Nakanishi, Y., Mar 1 2017, In : Supportive Care in Cancer. 25, 3, p. 925-932 8 p.

Research output: Contribution to journalArticle

Pain Management
Outpatients
Drug Therapy
Neoplasms
Pain
23 Citations (Scopus)

Monitoring of somatic mutations in circulating cell-free DNA by digital PCR and next-generation sequencing during afatinib treatment in patients with lung adenocarcinoma positive for EGFR activating mutations

Iwama, E., Sakai, K., Azuma, K., Harada, T., Harada, D., Nosaki, K., Hotta, K., Ohyanagi, F., Kurata, T., Fukuhara, T., Akamatsu, H., Goto, K., Shimose, T., Kishimoto, J., Nakanishi, Y., Nishio, K. & Okamoto, I., Jan 1 2017, In : Annals of Oncology. 28, 1, p. 136-141 6 p.

Research output: Contribution to journalArticle

Epidermal Growth Factor Receptor
Polymerase Chain Reaction
Mutation
DNA
Alleles
2 Citations (Scopus)

Neurocognitive profile of euthymic Japanese patients with bipolar disorder

Ishisaka, N., Shimano, S., Miura, T., Motomura, K., Horii, M., Imanaga, H., Kishimoto, J., Kaneda, Y., Sora, I. & Kanba, S., Jun 2017, In : Psychiatry and clinical neurosciences. 71, 6, p. 373-382 10 p.

Research output: Contribution to journalArticle

Bipolar Disorder
Consensus
Cognition
Meta-Analysis
Discriminant Analysis
8 Citations (Scopus)

Phase I study of salazosulfapyridine in combination with cisplatin and pemetrexed for advanced non-small-cell lung cancer

Otsubo, K., Nosaki, K., Imamura, C. K., Ogata, H., Fujita, A., Sakata, S., Hirai, F., Toyokawa, G., Iwama, E., Harada, T., Seto, T., Takenoyama, M., Ozeki, T., Mushiroda, T., Inada, M., Kishimoto, J., Tsuchihashi, K., Suina, K., Nagano, O., Saya, H. & 2 others, Nakanishi, Y. & Okamoto, I., Sep 2017, In : Cancer Science. 108, 9, p. 1843-1849 7 p.

Research output: Contribution to journalArticle

Pemetrexed
Sulfasalazine
Non-Small Cell Lung Carcinoma
Cisplatin
Neoplastic Stem Cells
4 Citations (Scopus)

Regulation of the embryonic erythropoietic niche: A future perspective

Yumine, A., Fraser, S. T. & Sugiyama, D., Jan 1 2017, In : Blood Research. 52, 1, p. 10-17 8 p.

Research output: Contribution to journalArticle

Erythropoiesis
Peptide Hydrolases
Peptides
Liver
Stem Cell Factor
35 Citations (Scopus)

The combination of PD-L1 expression and decreased tumorinfiltrating lymphocytes is associated with a poor prognosis in triple-negative breast cancer

Mori, H., Kubo, M., Yamaguchi, R., Nishimura, R., Osako, T., Arima, N., Okumura, Y., Okido, M., Yamada, M., Kai, M., Kishimoto, J., Oda, Y. & Nakamura, M., Jan 1 2017, In : Oncotarget. 8, 9, p. 15584-15592 9 p.

Research output: Contribution to journalArticle

Triple Negative Breast Neoplasms
Tumor-Infiltrating Lymphocytes
Cell Death
Lymphocytes
Ligands
2 Citations (Scopus)

Treatment Rationale and Design for J-AXEL: A Randomized Phase 3 Study Comparing Nab-Paclitaxel With Docetaxel in Patients With Previously Treated Advanced Non–Small-Cell Lung Cancer

Yoneshima, Y., Morita, S., Ando, M., Miura, S., Yoshioka, H., Abe, T., Kato, T., Kondo, M., Hosomi, Y., Hotta, K., Yamamoto, N., Kishimoto, J., Nakanishi, Y. & Okamoto, I., Jan 1 2017, In : Clinical Lung Cancer. 18, 1, p. 100-103 4 p.

Research output: Contribution to journalArticle

docetaxel
Non-Small Cell Lung Carcinoma
Nanoparticles
Therapeutics
Disease Progression
1 Citation (Scopus)

Twist1 regulates embryonic hematopoietic differentiation through binding to Myb and Gata2 promoter regions

Kulkeaw, K., Inoue, T., Iino, T., Tani, K., Akashi, K., Speck, N. A., Nakanishi, Y. & Sugiyama, D., Sep 12 2017, In : Blood Advances. 1, 20, p. 1672-1681 10 p.

Research output: Contribution to journalArticle

Open Access
Hematopoietic Stem Cells
Genetic Promoter Regions
Embryonic Stem Cells
Mesonephros
Lymphopoiesis
2016

Aryl hydrocarbon receptor antagonist stemregenin 1 promotes the expansion of human promyelocytic leukemia cell line, NB4

Koide, R., Kulkeaw, K., Tanaka, Y., Swain, A., Nakanishi, Y. & Sugiyama, D., Jan 1 2016, In : Anticancer research. 36, 7, p. 3635-3643 9 p.

Research output: Contribution to journalArticle

Aryl Hydrocarbon Receptors
Leukemia
Cell Line
B-Cell Lymphoma
Cyclin D1
11 Citations (Scopus)

BRCAness as a biomarker for predicting prognosis and response to anthracycline-based adjuvant chemotherapy for patients with triple-negative breast cancer

Mori, H., Kubo, M., Nishimura, R., Osako, T., Arima, N., Okumura, Y., Okido, M., Yamada, M., Kai, M., Kishimoto, J., Miyazaki, T., Oda, Y., Otsuka, T. & Nakamura, M., Dec 2016, In : PloS one. 11, 12, e0167016.

Research output: Contribution to journalArticle

anthracyclines
Triple Negative Breast Neoplasms
Chemotherapy
Anthracyclines
Biomarkers

DBA lectin binds to highly proliferative mouse erythroleukemia cells

Swain, A., Kulkeaw, K., Tanaka, Y., Nakanishi, Y., Shirasawa, S. & Sugiyama, D., Jan 1 2016, In : Anticancer research. 36, 7, p. 3625-3633 9 p.

Research output: Contribution to journalArticle

Leukemia, Erythroblastic, Acute
Lectins
Lens Plant
Cell Survival
Flow Cytometry

Efficacy and Safety of A0001 (Brilliant Blue G250) for Internal Limiting Membrane Staining and Peeling: Phase III Investigator-initiated Multicenter Clinical Trial

Enaida, H., Hirakata, A., Ohji, M., Nishida, K., Kubota, T., Ogata, N., Sonoda, K. H., Uchiyama, M., Kishimoto, J., Todaka, K., Nakanishi, Y. & Ishibashi, T., Jun 1 2016, In : Nippon Ganka Gakkai zasshi. 120, 6, p. 439-448 10 p.

Research output: Contribution to journalArticle

Vitrectomy
Multicenter Studies
Research Personnel
Clinical Trials
Staining and Labeling
3 Citations (Scopus)

Embryonic Intra-Aortic Clusters Undergo Myeloid Differentiation Mediated by Mesonephros-Derived CSF1 in Mouse

Sasaki, T., Tanaka, Y., Kulkeaw, K., Yumine-Takai, A., Tan, K. S., Nishinakamura, R., Ishida, J., Fukamizu, A. & Sugiyama, D., Oct 1 2016, In : Stem Cell Reviews and Reports. 12, 5, p. 530-542 13 p.

Research output: Contribution to journalArticle

Mesonephros
Gonads
Aorta
Caspase 3
Messenger RNA
1 Citation (Scopus)

Embryonic regulation of the mouse erythropoietic niche and its clinical application

Sugiyama, D., Tanaka, Y., Yumine, A. & Kojima, N., Jul 1 2016, In : [Rinsho ketsueki] The Japanese journal of clinical hematology. 57, 7, p. 944-950 7 p.

Research output: Contribution to journalArticle

Erythropoiesis
Liver
Hematopoiesis
Peptides
Peptide Hydrolases
7 Citations (Scopus)

Gefitinib Combined with Standard Chemoradiotherapy in EGFR-Mutant Locally Advanced Non-Small-Cell Lung Cancer: The LOGIK0902/OLCSG0905 Intergroup Study Protocol

Hotta, K., Sasaki, J., Saeki, S., Takigawa, N., Katsui, K., Takayama, K., Nogami, N., Shioyama, Y., Bessho, A., Kishimoto, J., Tanimoto, M., Kiura, K. & Ichinose, Y., Jan 1 2016, In : Clinical Lung Cancer. 17, 1, p. 75-79 5 p.

Research output: Contribution to journalArticle

Chemoradiotherapy
Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
docetaxel
Conformal Radiotherapy
22 Citations (Scopus)

Phase I clinical trial of a five-peptide cancer vaccine combined with cyclophosphamide in advanced solid tumors

Murahashi, M., Hijikata, Y., Yamada, K., Tanaka, Y., Kishimoto, J., Inoue, H., Marumoto, T., Takahashi, A., Okazaki, T., Takeda, K., Hirakawa, M., Fujii, H., Okano, S., Morita, M., Baba, E., Mizumoto, K., Maehara, Y., Tanaka, M., Akashi, K., Nakanishi, Y. & 5 others, Yoshida, K., Tsunoda, T., Tamura, K., Nakamura, Y. & Tani, K., May 1 2016, In : Clinical Immunology. 166-167, p. 48-58 11 p.

Research output: Contribution to journalArticle

Clinical Trials, Phase I
Cancer Vaccines
Subunit Vaccines
Neoplasm Antigens
Cyclophosphamide
9 Citations (Scopus)

Phase II trial of erlotinib in elderly patients with previously treated non-small cell lung cancer: Results of the lung oncology group in kyushu (LOGiK-0802)

Yamada, K., Azuma, K., Takeshita, M., Uchino, J., Nishida, C., Suetsugu, T., Kondo, A., Harada, T., Eida, H., Kishimoto, J., Eriguchi, G., Takayama, K., Nakanishi, Y. & Sugio, K., Jun 2016, In : Anticancer research. 36, 6, p. 2881-2887 7 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Lung Neoplasms
Poisons
Disease Progression
Erlotinib Hydrochloride
17 Citations (Scopus)

Prospective study of the UGT1A1*27 gene polymorphism during irinotecan therapy in patients with lung cancer: Results of Lung Oncology Group in Kyusyu (LOGIK1004B)

Fukuda, M., Suetsugu, T., Shimada, M., Kitazaki, T., Hashiguchi, K., Kishimoto, J., Harada, T., Seto, T., Ebi, N., Takayama, K., Sugio, K., Semba, H., Nakanishi, Y. & Ichinose, Y., Jul 1 2016, In : Thoracic Cancer. 7, 4, p. 467-472 6 p.

Research output: Contribution to journalArticle

irinotecan
Lung Neoplasms
Prospective Studies
Genes
Therapeutics
3 Citations (Scopus)

Prospects for Harmonizing Regulatory Science Programs in Europe, Japan, and the United States to Advance Regenerative Medicine

Milne, C. P., Mittra, J., Kojima, N., Sugiyama, D., Awatin, J. & Simmons, G., Nov 1 2016, In : Therapeutic Innovation and Regulatory Science. 50, 6, p. 724-733 10 p.

Research output: Contribution to journalArticle

Regenerative Medicine
Japan
Technology
Decision Making
Delivery of Health Care
8 Citations (Scopus)

Randomized Phase II Study of Docetaxel plus Personalized Peptide Vaccination versus Docetaxel plus Placebo for Patients with Previously Treated Advanced Wild Type EGFR Non-Small-Cell Lung Cancer

Takayama, K., Sugawara, S., Saijo, Y., Maemondo, M., Sato, A., Takamori, S., Harada, T., Sasada, T., Kakuma, T., Kishimoto, J., Yamada, A., Noguchi, M., Itoh, K. & Nakanishi, Y., Jan 1 2016, In : Journal of Immunology Research. 2016, 1745108.

Research output: Contribution to journalArticle

docetaxel
Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
Vaccination
Placebos
3 Citations (Scopus)

Sequential morphological change of Chiari malformation type II following surgical repair of myelomeningocele

Hashiguchi, K., Morioka, T., Murakami, N., Togao, O., Hiwatashi, A., Ochiai, M., Eriguchi, G., Kishimoto, J. & Iihara, K., Jun 1 2016, In : Child's Nervous System. 32, 6, p. 1069-1078 10 p.

Research output: Contribution to journalArticle

Arnold-Chiari Malformation
Foramen Magnum
Meningomyelocele
Spina Bifida Cystica
Hydrocephalus

The efficacy and safety of cefepime or meropenem in the treatment of febrile neutropenia in patients with lung cancer. A randomized phase II study

Lung Oncology Group in Kyushu (LOGIK), Apr 1 2016, In : Journal of Infection and Chemotherapy. 22, 4, p. 235-239 5 p.

Research output: Contribution to journalArticle

meropenem
Febrile Neutropenia
Lung Neoplasms
Safety
Therapeutics
2015
4 Citations (Scopus)

3D MR Sequence Capable of Simultaneous Image Acquisitions with and without Blood Vessel Suppression: Utility in Diagnosing Brain Metastases

Kikuchi, K., Hiwatashi, A., Togao, O., Yamashita, K., Yoneyama, M., Obara, M., Kishimoto, J., Yoshiura, T. & Honda, H., Mar 12 2015, In : European Radiology. 25, 4, p. 901-910 10 p.

Research output: Contribution to journalArticle

Blood Vessels
Neoplasm Metastasis
Brain
Reading
Noise
8 Citations (Scopus)

Aloe vera extract suppresses proliferation of neuroblastoma cells in vitro

Yonehara, A., Tanaka, Y., Kulkeaw, K., Era, T., Nakanishi, Y. & Sugiyama, D., Aug 1 2015, In : Anticancer research. 35, 8, p. 4479-4486 8 p.

Research output: Contribution to journalArticle

Aloe
Neuroblastoma
Cell Proliferation
Proteins
In Vitro Techniques

Apoptosis-inducing factor, mitochondrion-associated 2, regulates Klf1 in a mouse erythroleukemia cell line

Kojima, N., Tanaka, Y., Kulkeaw, K., Nakanishi, Y., Shirasawa, S. & Sugiyama, D., Aug 1 2015, In : Anticancer research. 35, 8, p. 4493-4500 8 p.

Research output: Contribution to journalArticle

Apoptosis Inducing Factor
Leukemia, Erythroblastic, Acute
Mitochondria
Cell Line
Globins
3 Citations (Scopus)

Embryonic hematopoietic progenitor cells reside in muscle before bone marrow hematopoiesis

Tanaka, Y., Inoue-Yokoo, T., Kulkeaw, K., Yanagi-Mizuochi, C., Shirasawa, S., Nakanishi, Y. & Sugiyama, D., Sep 21 2015, In : PloS one. 10, 9, e0138621.

Research output: Contribution to journalArticle

hematopoiesis
Hematopoiesis
Hematopoietic Stem Cells
bone marrow
Muscle
19 Citations (Scopus)

Highly sensitive and quantitative evaluation of the EGFR T790M mutation by nanofluidic digital PCR

Iwama, E., Takayama, K., Harada, T., Okamoto, I., Ookubo, F., Kishimoto, J., Baba, E., Oda, Y. & Nakanishi, Y., Jan 1 2015, In : Oncotarget. 6, 24, p. 20466-20473 8 p.

Research output: Contribution to journalArticle

Polymerase Chain Reaction
Mutation
Alleles
Therapeutics
Neoplasms
1 Citation (Scopus)

Inhibition of RANKL-dependent cellular fusion in pre-osteoclasts by amiloride and a NHE10-specific monoclonal antibody

Mine, Y., Shuto, T., Nikawa, H., Kawai, T., Ohara, M., Kawahara, K., Ohta, K., Kukita, T., Terada, Y. & Makihira, S., Jun 1 2015, In : Cell Biology International. 39, 6, p. 696-709 14 p.

Research output: Contribution to journalArticle

Amiloride
Osteoclasts
Sodium-Hydrogen Antiporter
Monoclonal Antibodies
Cell Differentiation
5 Citations (Scopus)

Localized SCF and IGF-1 secretion enhances erythropoiesis in the spleen of murine embryos

Tan, K. S., Inoue, T., Kulkeaw, K., Tanaka, Y., Lai, M. I. & Sugiyama, D., May 15 2015, In : Biology Open. 4, 5, p. 596-607 12 p.

Research output: Contribution to journalArticle

erythropoiesis
Globins
Erythropoiesis
Insulin-Like Growth Factor I
embryo (animal)

Neural substrates of species-dependent visual processing of faces: Use of morphed faces

Yamada, E., Ogata, K., Kishimoto, J., Tanaka, M., Urakawa, T., Yamasaki, T. & Tobimatsu, S., Jan 1 2015, In : Physiological Reports. 3, 5, e12387.

Research output: Contribution to journalArticle

Parietal Lobe
Evoked Potentials
Haplorhini
Biomarkers
Communication
11 Citations (Scopus)

Prevalence of dyslipidemia in Japanese patients with rheumatoid arthritis and effects of atorvastatin treatment

Akiyama, M., Mawatari, T., Nakashima, Y., Miyahara, H., Yamada, H., Okazaki, K., Fukushi, J. I., Kondo, M., Kishimoto, J., Hashimura, C. & Iwamoto, Y., Aug 21 2015, In : Clinical Rheumatology. 34, 11, p. 1867-1875 9 p.

Research output: Contribution to journalArticle

Dyslipidemias
Rheumatoid Arthritis
HDL Cholesterol
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Therapeutics

Unusual self revealing nuclear segmentation in a neutrophil from primary bone marrow cells in Mus musculus

Swain, A. & Jones, D. R. E., Jan 1 2015, In : Comparative Clinical Pathology. 24, 2, 1 p.

Research output: Contribution to journalArticle

Bone Marrow Cells
Neutrophils
Bone Marrow
2014
21 Citations (Scopus)

Acute hyperglycemia impairs functional improvement after spinal cord injury in mice and humans

Kobayakawa, K., Kumamaru, H., Saiwai, H., Kubota, K., Ohkawa, Y., Kishimoto, J., Yokota, K., Ideta, R., Shiba, K., Tozaki-Saitoh, H., Inoue, K., Iwamoto, Y. & Okada, S., Oct 1 2014, In : Science Translational Medicine. 6, 256, 256ra137.

Research output: Contribution to journalArticle

Spinal Cord Injuries
Hyperglycemia
Obese Mice
Nervous System Trauma
Blood Glucose
9 Citations (Scopus)

A feasibility trial of postoperative adjuvant chemotherapy with S-1, an oral fluoropyrimidine, for elderly patients with non-small cell lung cancer: A report of the Lung Oncology Group in Kyushu (LOGIK) protocol 0901

Maruyama, R., Ebi, N., Kishimoto, J., Kato, M., Yano, T., Nagamatsu, Y., Tsukamoto, S., Akamine, S., Saeki, S. & Ichinose, Y., Feb 1 2014, In : International Journal of Clinical Oncology. 19, 1, p. 57-62 6 p.

Research output: Contribution to journalArticle

Adjuvant Chemotherapy
Non-Small Cell Lung Carcinoma
Lung
Appointments and Schedules
Confidence Intervals
7 Citations (Scopus)

Can intensive lipid-lowering therapy improve the carotid Intima-media thickness in Japanese subjects under primary prevention for cardiovascular disease? The JART and JART extension subanalysis

Daida, H., Nohara, R., Hata, M., Kaku, K., Kawamori, R., Kishimoto, J., Kurabayashi, M., Masuda, I., Sakuma, I., Yamazaki, T., Yokoi, H. & Yoshida, M., 2014, In : Journal of atherosclerosis and thrombosis. 21, 7, p. 739-754 16 p.

Research output: Contribution to journalArticle

Carotid Intima-Media Thickness
Primary Prevention
Atherosclerosis
Cardiovascular Diseases
Lipids
9 Citations (Scopus)

Close correlation between CXCR4 and VEGF expression and frequent CXCR7 expression in rhabdomyosarcoma

Miyoshi, K., Kohashi, K., Fushimi, F., Yamamoto, H., Kishimoto, J., Taguchi, T., Iwamoto, Y. & Oda, Y., Sep 2014, In : Human Pathology. 45, 9, p. 1900-1909 10 p.

Research output: Contribution to journalArticle

CXCR Receptors
CXCR4 Receptors
Rhabdomyosarcoma
Vascular Endothelial Growth Factor A
Alveolar Rhabdomyosarcoma