Research Output 1980 2020

2019

CD206+ tumor-associated macrophages promote proliferation and invasion in oral squamous cell carcinoma via EGF production

Haque, A. S. M. R., Moriyama, M., Kubota, K., Ishiguro, N., Sakamoto, M., Chinju, A., Mochizuki, K., Sakamoto, T., Kaneko, N., Munemura, R., Maehara, T., Tanaka, A., Hayashida, J. N., Kawano, S., Kiyoshima, T. & Nakamura, S., Dec 1 2019, In : Scientific reports. 9, 1, 14611.

Research output: Contribution to journalArticle

Open Access
Epidermal Growth Factor
Squamous Cell Carcinoma
Macrophages
Neoplasms
Conditioned Culture Medium
Phase II Clinical Trials
Clinical Trials, Phase I
Systemic Scleroderma
Hematopoietic Stem Cell Transplantation
Japan
8 Citations (Scopus)

Cell-based screen identifies a new potent and highly selective CK2 inhibitor for modulation of circadian rhythms and cancer cell growth

Oshima, T., Niwa, Y., Kuwata, K., Srivastava, A., Hyoda, T., Tsuchiya, Y., Kumagai, M., Tsuyuguchi, M., Tamaru, T., Sugiyama, A., Ono, N., Zolboot, N., Aikawa, Y., Oishi, S., Nonami, A., Arai, F., Hagihara, S., Yamaguchi, J., Tama, F., Kunisaki, Y. & 6 others, Yagita, K., Ikeda, M., Kinoshita, T., Kay, S. A., Itami, K. & Hirota, T., Jan 23 2019, In : Science Advances. 5, 1, eaau9060.

Research output: Contribution to journalArticle

Open Access
Circadian Rhythm
Circadian Clocks
Phosphotransferases
Growth
Neoplasms

Cerebrospinal fluid cytokine/chemokine/growth factor profiles in idiopathic hypertrophic pachymeningitis

Zhang, X., Fujii, T., Ogata, H., Yamasaki, R., Masaki, K., Cui, Y., Matsushita, T., Isobe, N. & Kira, J-I., May 15 2019, In : Journal of Neuroimmunology. 330, p. 38-43 6 p.

Research output: Contribution to journalArticle

Nervous System Diseases
Meningitis
Chemokines
Cerebrospinal Fluid
Intercellular Signaling Peptides and Proteins

Cessation of nilotinib in patients with chronic myelogenous leukemia who have maintained deep molecular responses for 2 years: a multicenter phase 2 trial, stop nilotinib (NILSt)

Nagafuji, K., Matsumura, I., Shimose, T., Kawaguchi, T., Kuroda, J., Nakamae, H., Miyamoto, T., Kadowaki, N., Ishikawa, J., Imamura, Y., Yamazaki, H., Akashi, K. & Kanakura, Y., Dec 1 2019, In : International journal of hematology. 110, 6, p. 675-682 8 p.

Research output: Contribution to journalArticle

Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Leukemia, Myeloid, Chronic Phase
Therapeutics
4-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamide
Recurrence

Chemically Fueled Plasmon Switching of Gold Nanorods by Single-Base Pairing of Surface-Grafted DNA

Zhang, L., Zhao, C., Zhang, Y., Wang, L., Wang, G., Kanayama, N., Takarada, T., Maeda, M. & Liang, X., Sep 10 2019, In : Langmuir : the ACS journal of surfaces and colloids. 35, 36, p. 11710-11716 7 p.

Research output: Contribution to journalArticle

Thymine
thymine
Nanorods
Gold
nanorods

Chemokine levels predict progressive liver disease in Down syndrome patients with transient abnormal myelopoiesis

Kinjo, T., Inoue, H., Kusuda, T., Fujiyoshi, J., Ochiai, M., Takahata, Y., Honjo, S., Koga, Y., Hara, T. & Ohga, S., Aug 2019, In : Pediatrics and Neonatology. 60, 4, p. 382-388 7 p.

Research output: Contribution to journalArticle

Down Syndrome
Chemokines
Liver Failure
Liver Diseases
Chemokine CXCL9
1 Citation (Scopus)
Androgen Antagonists
Androgen Receptors
docetaxel
Prostatic Neoplasms
Smoking
3 Citations (Scopus)

CKAP4, a DKK1 receptor, is a biomarker in exosomes derived from pancreatic cancer and a molecular target for therapy

Kimura, H., Yamamoto, H., Harada, T., Fumoto, K., Osugi, Y., Sada, R., Maehara, N., Hikita, H., Mori, S., Eguchi, H., Ikawa, M., Takehara, T. & Kikuchi, A., Jan 1 2019, In : Clinical Cancer Research. 25, 6, p. 1936-1947 12 p.

Research output: Contribution to journalArticle

Exosomes
Cytoskeleton
Pancreatic Neoplasms
Biomarkers
Adenocarcinoma
1 Citation (Scopus)

Clarifying deeper psychological characteristics of hikikomori using the rorschach comprehensive system: A pilot case-control study

Katsuki, R., Inoue, A., Indias, S., Kurahara, K., Kuwano, N., Funatsu, F., Kubo, H., Kanba, S. & Kato, T. A., Jan 1 2019, In : Frontiers in Psychiatry. 10, JUN, 412.

Research output: Contribution to journalArticle

Open Access
Case-Control Studies
Psychology
Personality
Emotions
Rorschach Test

CLEC3A, MMP7, and LCN2 as novel markers for predicting recurrence in resected G1 and G2 pancreatic neuroendocrine tumors

Miki, M., Oono, T., Fujimori, N., Takaoka, T., Kawabe, K., Miyasaka, Y., Ohtsuka, T., Saito, D., Nakamura, M., Ohkawa, Y., Oda, Y., Suyama, M., Ito, T. & Ogawa, Y., Jul 2019, In : Cancer Medicine. 8, 8, p. 3748-3760 13 p.

Research output: Contribution to journalArticle

Open Access
Matrix Metalloproteinase 7
Neuroendocrine Tumors
Recurrence
Genes
Neoplasms

Clinical and Prognostic Significance of the Epithelial–Mesenchymal Transition in Stage IA Lung Adenocarcinoma: A Propensity Score–Matched Analysis

Matsubara, T., Tagawa, T., Takada, K., Toyokawa, G., Shimokawa, M., Kozuma, Y., Akamine, T., Haro, A., Osoegawa, A. & Mori, M., Jul 1 2019, In : Clinical Lung Cancer. 20, 4, p. e504-e513

Research output: Contribution to journalArticle

Propensity Score
Vimentin
Cadherins
Neoplasms
Disease-Free Survival

Clinical assessment of the GNAS mutation status in patients with intraductal papillary mucinous neoplasm of the pancreas

Ohtsuka, T., Tomosugi, T., Kimura, R., Nakamura, S., Miyasaka, Y., Nakata, K., Mori, Y., Morita, M., Torata, N., Shindo, K., Ohuchida, K. & Nakamura, M., Nov 1 2019, In : Surgery today. 49, 11, p. 887-893 7 p.

Research output: Contribution to journalReview article

Pancreatic Neoplasms
Mutation
Adenocarcinoma
Endoscopic Ultrasound-Guided Fine Needle Aspiration
Pancreatic Ducts

Clinical characteristics and prognostic factors in acute coronary syndrome patients complicated with cardiogenic shock in Japan: analysis from the Japanese Circulation Society Cardiovascular Shock Registry

Sakamoto, K., Matoba, T., Mohri, M., Ueki, Y., Tsujita, Y., Yamasaki, M., Tanaka, N., Hokama, Y., Fukutomi, M., Hashiba, K., Fukuhara, R., Suwa, S., Matsuura, H., Tachibana, E., Yonemoto, N. & Nagao, K., Aug 1 2019, In : Heart and Vessels. 34, 8, p. 1241-1249 9 p.

Research output: Contribution to journalArticle

Cardiogenic Shock
Acute Coronary Syndrome
Registries
Shock
Japan

Clinical Characterization of Vonoprazan-Refractory Gastroesophageal Reflux Disease

Hamada, S., Ihara, E., Ikeda, H., Muta, K., Ogino, H., Chinen, T., Tanaka, Y. & Ogawa, Y., Jan 1 2019, (Accepted/In press) In : Digestion.

Research output: Contribution to journalArticle

Gastroesophageal Reflux
Proton Pump Inhibitors
Acids
Esophageal Motility Disorders
Heartburn
2 Citations (Scopus)

Clinical effects of recombinant thrombomodulin and defibrotide on sinusoidal obstruction syndrome after allogeneic hematopoietic stem cell transplantation

Yakushijin, K., Ikezoe, T., Ohwada, C., Kudo, K., Okamura, H., Goto, H., Yabe, H., Yasumoto, A., Kuwabara, H., Fujii, S., Kagawa, K., Ogata, M., Onishi, Y., Kohno, A., Watamoto, K., Uoshima, N., Nakamura, D., Ota, S., Ueda, Y., Oyake, T. & 9 others, Koike, K., Mizuno, I., Iida, H., Katayama, Y., Ago, H., Kato, K., Okamura, A., Kikuta, A. & Fukuda, T., May 1 2019, In : Bone Marrow Transplantation. 54, 5, p. 674-680 7 p.

Research output: Contribution to journalArticle

Hepatic Veno-Occlusive Disease
Thrombomodulin
Hematopoietic Stem Cell Transplantation
human THBD protein
defibrotide

Clinical pharmacology research for promoting individualized cancer chemotherapy

Watanabe, H., Uchida, M. & Masuda, S., Jan 1 2019, In : Yakugaku Zasshi. 139, 6, p. 901-909 9 p.

Research output: Contribution to journalReview article

Open Access
Clinical Pharmacology
aprepitant
Antiemetics
Drug Therapy
Research

Clinical prospects of biomarkers for the early detection and/or prediction of organ injury associated with pharmacotherapy

Tajima, S., Yamamoto, N. & Masuda, S., Dec 2019, In : Biochemical Pharmacology. 170, 113664.

Research output: Contribution to journalReview article

Drug therapy
Biomarkers
Kidney
Drug Therapy
Wounds and Injuries
Heavy Ion Radiotherapy
Sarcoma
Spine
Spinal Cord Compression
Compression Fractures
1 Citation (Scopus)

Clinical significance of monitoring EGFR mutation in plasma using multiplexed digital PCR in EGFR mutated patients treated with afatinib (West Japan Oncology Group 8114LTR study)

Akamatsu, H., Koh, Y., Okamoto, I., Fujimoto, D., Bessho, A., Azuma, K., Morita, S., Yamamoto, N. & Nakagawa, K., May 1 2019, In : Lung Cancer. 131, p. 128-133 6 p.

Research output: Contribution to journalArticle

Open Access
Epidermal Growth Factor Receptor
Japan
Polymerase Chain Reaction
Mutation
Non-Small Cell Lung Carcinoma
Balloon Angioplasty
Pulmonary Hypertension
Lung
Therapeutics
ROC Curve

Clinical Utility of Highly Purified 10% Liquid Intravenous Immunoglobulin in Kawasaki Disease

Oda, T., Nagata, H., Nakashima, Y., Nanishi, E., Takada, Y., Nishimura, M., Kubo, E., Hatae, K. & Ohga, S., Nov 2019, In : Journal of Pediatrics. 214, p. 227-230 4 p.

Research output: Contribution to journalArticle

Mucocutaneous Lymph Node Syndrome
Intravenous Immunoglobulins
Fever
Therapeutics
1 Citation (Scopus)

Clinicopathological characteristics of non-functioning cystic pancreatic neuroendocrine tumors

Nakashima, Y., Takao, O., Nakamura, S., Mori, Y., Nakata, K., Miyasaka, Y., Ishigami, K., Matsuda, R., Oda, Y. & Nakamura, M., Jan 1 2019, In : Pancreatology. 19, 1, p. 50-56 7 p.

Research output: Contribution to journalArticle

Neuroendocrine Tumors
Neoplasm Metastasis
Primitive Neuroectodermal Tumors
Somatostatin Receptors
Somatostatin
Adenoma
Colorectal Neoplasms
DNA Mismatch Repair
Carcinoma
Mutation

Clinicopathological features of HCV-positive splenic diffuse large B cell lymphoma

Shimono, J., Miyoshi, H., Arakawa, F., Yamada, K., Sugio, T., Miyawaki, K., Eto, T., Miyagishima, T., Kato, K., Nagafuji, K., Akashi, K., Teshima, T. & Ohshima, K., May 1 2019, In : Annals of Hematology. 98, 5, p. 1197-1207 11 p.

Research output: Contribution to journalArticle

Lymphoma, Large B-Cell, Diffuse
Hepacivirus
B-Cell Lymphoma
RNA
Reverse Transcription
5 Citations (Scopus)

Co-expression of IDO1 and PD-L1 in lung squamous cell carcinoma: Potential targets of novel combination therapy

Takada, K., Kouhashi, K., Shimokawa, M., Haro, A., Osoegawa, A., Tagawa, T., Seto, T., Oda, Y. & Maehara, Y., Feb 1 2019, In : Lung Cancer. 128, p. 26-32 7 p.

Research output: Contribution to journalArticle

CD274 Antigen
Indoleamine-Pyrrole 2,3,-Dioxygenase
Squamous Cell Carcinoma
Lung
Therapeutics

Coffee drinking and risk of all-cause mortality and cardiovascular diseases

Hirakawa, Y., Apr 1 2019, In : Circulation Journal. 83, 4, p. 711-712 2 p.

Research output: Contribution to journalEditorial

Open Access
Coffee
Drinking
Cardiovascular Diseases
Mortality

Colorectal endoscopic submucosal dissection using novel articulating devices: a comparative study in a live porcine model

Okamoto, Y., Nakadate, R., Nakamura, S., Arata, J., Oguri, S., Tomohiko, M., Esaki, M., iwasa, T., Ouchida, K., Akahoshi, T., Ikeda, T., Kitazono, T. & Hashizume, M., Feb 15 2019, In : Surgical endoscopy. 33, 2, p. 651-657 7 p.

Research output: Contribution to journalArticle

Swine
Equipment and Supplies
Endoscopic Mucosal Resection
Anal Canal
Colon
Sarcoma
Neoplasms
Neoplasm Metastasis
Recurrence

Comparison of calcineurin inhibitors in combination with conventional methotrexate, reduced methotrexate, or mycophenolate mofetil for prophylaxis of graft-versus-host disease after umbilical cord blood transplantation

Yoshida, S., Ohno, Y., Nagafuji, K., Yoshimoto, G., Sugio, T., Kamimura, T., Ohta, T., Takase, K., Henzan, H., Muta, T., Iwasaki, H., Ogawa, R., Eto, T., Akashi, K. & Miyamoto, T., Nov 1 2019, In : Annals of Hematology. 98, 11, p. 2579-2591 13 p.

Research output: Contribution to journalArticle

Mycophenolic Acid
Graft vs Host Disease
Fetal Blood
Methotrexate
Transplantation
Open Access
Aortic Valve
Surgical Instruments
Pressure
Stroke
Stroke Volume
Phase II Clinical Trials
Colorectal Neoplasms
Tomography
Drug Therapy
Neoplasms
1 Citation (Scopus)
Open Access
end effectors
End effectors
strokes
Brain computer interface
recovery
Retrospective Studies
Pediatrics
Touch
Anesthetics
Isoflurane
Masks
Air
Ventilation
Oral Surgery
Tidal Volume

Comparison of volumetric-modulated arc therapy and intensity-modulated radiation therapy prostate cancer plans accounting for cold spots

Nguyen, T. T. T., Arimura, H., Asamura, R., Hirose, T. A., Ohga, S. & Fukunaga, J. I., Jun 1 2019, In : Radiological physics and technology. 12, 2, p. 137-148 12 p.

Research output: Contribution to journalArticle

Intensity-Modulated Radiotherapy
radiation therapy
therapy
Prostatic Neoplasms
rectum
1 Citation (Scopus)

Comprehensive assay for the molecular profiling of cancer by target enrichment from formalin-fixed paraffin-embedded specimens

Kohsaka, S., Tatsuno, K., Ueno, T., Nagano, M., Shinozaki-Ushiku, A., Ushiku, T., Takai, D., Ikegami, M., Kobayashi, H., Kage, H., Ando, M., Hata, K., Ueda, H., Yamamoto, S., Kojima, S., Oseto, K., Akaike, K., Suehara, Y., Hayashi, T., Saito, T. & 19 others, Takahashi, F., Takahashi, K., Takamochi, K., Suzuki, K., Nagayama, S., Oda, Y., Mimori, K., Ishihara, S., Yatomi, Y., Nagase, T., Nakajima, J., Tanaka, S., Fukayama, M., Oda, K., Nangaku, M., Miyazono, K., Miyagawa, K., Aburatani, H. & Mano, H., Apr 2019, In : Cancer Science. 110, 4, p. 1464-1479 16 p.

Research output: Contribution to journalArticle

Open Access
Paraffin
Formaldehyde
RNA
Neoplasms
Microsatellite Instability

Connecting Nanoparticles with Different Colloidal Stability by DNA for Programmed Anisotropic Self-Assembly

Yu, L., Shiraishi, S., Wang, G., Akiyama, Y., Takarada, T. & Maeda, M., Jun 20 2019, In : Journal of Physical Chemistry C. 123, 24, p. 15293-15300 8 p.

Research output: Contribution to journalArticle

Self assembly
self assembly
Anisotropy
DNA
deoxyribonucleic acid

Constitutive activation of mTORC1 signaling induced by biallelic loss-of-function mutations in SZT2 underlies a discernible neurodevelopmental disease

Nakamura, Y., Kato, K., Tsuchida, N., Matsumoto, N., Takahashi, Y. & Saitoh, S., Jan 1 2019, In : PloS one. 14, 8, e0221482.

Research output: Contribution to journalArticle

Open Access
Chemical activation
Cell Line
Mutation
cell lines
Cells

Construction of multimodal 3D model of pancreatic cancer tumor

Goto, Y., Kugler, M., Yokota, T., Iwamoto, C., Ouchida, K., Hashizume, M. & Hontani, H., Jan 1 2019, International Forum on Medical Imaging in Asia 2019. Lin, F., Kim, J. H. & Fujita, H. (eds.). SPIE, 110501H. (Proceedings of SPIE - The International Society for Optical Engineering; vol. 11050).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3D Model
Registration
Tumors
Tumor
Cancer
Open Access
Temporal Lobe
Hippocampus
Stroke
Radiation
Epilepsy

Continuous skill training using the disease-specific endoscopic surgical simulator to promote young pediatric surgeons: Learning curve for trainees

Fukuta, A., Obata, S., Jimbo, T., Kono, J., Souzaki, R., Matsuoka, N., Katayama, T. & Taguchi, T., Oct 2019, In : Journal of Laparoendoscopic and Advanced Surgical Techniques. 29, 10, p. 1334-1341 8 p.

Research output: Contribution to journalArticle

Learning Curve
Surgical Instruments
Pediatrics
Learning
Sutures
Hematology
Multiple Myeloma
Fees and Charges
Pharmaceutical Preparations
Organized Financing
Open Access
Myasthenia Gravis
Internet
Fatigue
Quality of Life
Research
Body Temperature
Publications
Anesthesia
Nervous System
Names
Tail
Skin

Correlation between prognosis of glioblastoma and choline/N-acetyl aspartate ratio in MR spectroscopy

Akagi, Y., Noguchi, N., Hata, N., Hatae, R., Michiwaki, Y., sangatsuda, Y., Amemiya, T., Kuga, D., Yamashita, K., Togao, O., Akio, H., Yoshimoto, K., Mizoguchi, M. & Iihara, K., Dec 1 2019, In : Interdisciplinary Neurosurgery: Advanced Techniques and Case Management. 18, 100498.

Research output: Contribution to journalArticle

Open Access
Glioblastoma
Choline
Magnetic Resonance Spectroscopy
N-acetylaspartate

Corrigendum to “Effects of menstrual cycle on background parenchymal enhancement and detectability of breast cancer on dynamic contrast-enhanced breast MRI: A multicenter study of an Asian population” [Eur. J. Radiol. 110 (2019) 130–135] (European Journal of Radiology (2019) 110 (130–135), (S0720048X18304200), (10.1016/j.ejrad.2018.11.025))

Kamitani, T., Yabuuchi, H., Kanemaki, Y., Tozaki, M., Sonomura, T., Mizukoshi, W., Nakata, W., Shimono, T., Urano, M., Yamano, T., Kato, F., Kuchiki, M., Shiraga, N., Yanagita, H., Katsuda, E., Kataoka, M., Yamaguchi, K., Horikoshi, T., Gomi, T., Nozaki, M. & 9 others, Shiotani, M., Amano, M., Saigusa, H., Sadaoka, S., Kamiya, H., Kubo, M., Yamashita, N., Yamamoto, H. & Honda, H., May 1 2019, In : European Journal of Radiology. 114, 1 p.

Research output: Contribution to journalComment/debate

Menstrual Cycle
Radiology
Multicenter Studies
Names
Breast

Cost-effectiveness analysis of sofosbuvir plus ribavirin in patients with genotype 2 chronic hepatitis C: An analysis with real world outcomes from a multicentre cohort in Japan

Igarashi, A., Furusyo, N., Ogawa, E., Nomura, H., Dohmen, K., Higashi, N., Takahashi, K., Kawano, A., Azuma, K., Satoh, T., Nakamuta, M., Koyanagi, T., Kato, M., Shimoda, S., Kajiwara, E. & Hayashi, J., Jun 1 2019, In : BMJ open. 9, 6, e023405.

Research output: Contribution to journalArticle

Open Access
Ribavirin
Chronic Hepatitis C
Cost-Benefit Analysis
Japan
Genotype
3 Citations (Scopus)

C-reactive protein/albumin ratio is a poor prognostic factor of esophagogastric junction and upper gastric cancer

Kudou, K., Saeki, H., Nakashima, Y., Kamori, T., Kawazoe, T., Haruta, Y., Fujimoto, Y., Matsuoka, H., Sasaki, S., Jogo, T., Hirose, K., Hu, Q., Tsuda, Y., Kimura, K., Andou, K., Oki, E., Ikeda, T. & Maehara, Y., Feb 1 2019, In : Journal of Gastroenterology and Hepatology (Australia). 34, 2, p. 355-363 9 p.

Research output: Contribution to journalReview article

Esophagogastric Junction
C-Reactive Protein
Stomach Neoplasms
Albumins
Adenocarcinoma