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Research Output 2005 2019

  • 515 Citations
  • 13 h-Index
  • 23 Article
  • 6 Review article
  • 1 Chapter
  • 1 Comment/debate
2019

Depolysulfidation of Drp1 induced by low-dose methylmercury exposure increases cardiac vulnerability to hemodynamic overload

Nishimura, A., Shimoda, K., Tanaka, T., Toyama, T., Nishiyama, K., Shinkai, Y., Numaga-Tomita, T., Yamazaki, D., Kanda, Y., Akaike, T., Kumagai, Y. & Nishida, M., Jan 1 2019, In : Science Signaling. 12, 587, eaaw1920.

Research output: Contribution to journalArticle

Filamins
Hemodynamics
Cardiac Myocytes
Oxidation-Reduction
Rats
1 Citation (Scopus)

Ibudilast attenuates doxorubicin-induced cytotoxicity by suppressing formation of TRPC3 channel and NADPH oxidase 2 protein complexes

Nishiyama, K., Numaga-Tomita, T., Fujimoto, Y., Tanaka, T., Toyama, C., Nishimura, A., Yamashita, T., Naoya, M., Satoru, K., Azuma, Y. T., Ibuki, Y., Uchida, K., Ohdo, S. & Nishida, M., Sep 1 2019, In : British Journal of Pharmacology. 176, 18, p. 3723-3738 16 p.

Research output: Contribution to journalArticle

NADPH Oxidase
Doxorubicin
Tobacco Smoke Pollution
Proteins
Pharmaceutical Preparations
1 Citation (Scopus)

Mitochondrial dynamics in exercise physiology

Tanaka, T., Nishimura, A., Nishiyama, K., Goto, T., Numaga-Tomita, T. & Nishida, M., Jan 1 2019, In : Pflugers Archiv European Journal of Physiology.

Research output: Contribution to journalReview article

Mitochondrial Dynamics
Physiology
Organelle Biogenesis
Post Translational Protein Processing
Homeostasis

Monitoring RhoGDI extraction of lipid-modified Rho GTPases from membranes using click chemistry

Nishimura, A. & Linder, M. E., Jan 1 2019, Methods in Molecular Biology. Humana Press Inc., p. 297-306 10 p. (Methods in Molecular Biology; vol. 2009).

Research output: Chapter in Book/Report/Conference proceedingChapter

Click Chemistry
rho GTP-Binding Proteins
Lipids
Membranes
Terpenes

TRPC3-Nox2 axis mediates nutritional deficiency-induced cardiomyocyte atrophy

Sudi, S. B., Tanaka, T., Oda, S., Nishiyama, K., Nishimura, A., Sunggip, C., Mangmool, S., Numaga-Tomita, T. & Nishida, M., Dec 1 2019, In : Scientific reports. 9, 1, 9785.

Research output: Contribution to journalArticle

Open Access
Cardiac Myocytes
Malnutrition
Atrophy
Adenosine Triphosphate
Reactive Oxygen Species
1 Citation (Scopus)

TRPC6 regulates phenotypic switching of vascular smooth muscle cells through plasma membrane potential-dependent coupling with PTEN

Numaga-Tomita, T., Shimauchi, T., Oda, S., Tanaka, T., Nishiyama, K., Nishimura, A., Birnbaumer, L., Mori, Y. & Nishida, M., Sep 1 2019, In : FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 33, 9, p. 9785-9796 12 p.

Research output: Contribution to journalArticle

Cell membranes
Vascular Smooth Muscle
Membrane Potentials
Smooth Muscle Myocytes
Muscle
2 Citations (Scopus)

TRPC channels in exercise-mimetic therapy

Numaga-Tomita, T., Oda, S., Nishiyama, K., Tanaka, T., Nishimura, A. & Nishida, M., Mar 7 2019, In : Pflugers Archiv European Journal of Physiology. 471, 3, p. 507-517 11 p.

Research output: Contribution to journalReview article

Exercise Therapy
Muscle
Mechanical Stress
Proteins
Oxidative stress
2018
9 Citations (Scopus)

Hypoxia-induced interaction of filamin with Drp1 causes mitochondrial hyperfission-associated myocardial senescence

Nishimura, A., Shimauchi, T., Tanaka, T., Shimoda, K., Toyama, T., Kitajima, N., Ishikawa, T., Shindo, N., Numaga-Tomita, T., Yasuda, S., Sato, Y., Kuwahara, K., Kumagai, Y., Akaike, T., Ide, T., Ojida, A., Mori, Y. & Nishida, M., Nov 13 2018, In : Science Signaling. 11, 556, eaat5185.

Research output: Contribution to journalArticle

Filamins
Dynamins
Actins
Mitochondrial Dynamics
Proteins

Prolonged stimulation of β2-adrenergic receptor with β2-agonists impairs insulin actions in H9c2 cells

Parichatikanond, W., Nishimura, A., Nishida, M. & Mangmool, S., Nov 1 2018, In : Journal of Pharmacological Sciences. 138, 3, p. 184-191 8 p.

Research output: Contribution to journalArticle

Adrenergic Receptors
Insulin Resistance
Insulin
Glucose
Smooth Muscle Myocytes
5 Citations (Scopus)

TRPC5-eNOS axis negatively regulates ATP-induced cardiomyocyte hypertrophy

Sunggip, C., Shimoda, K., Oda, S., Tanaka, T., Nishiyama, K., Mangmool, S., Nishimura, A., Numaga-Tomita, T. & Nishida, M., May 22 2018, In : Frontiers in Pharmacology. 9, MAY, 523.

Research output: Contribution to journalArticle

Cardiac Myocytes
Hypertrophy
Adenosine Triphosphate
NFATC Transcription Factors
Cyclic GMP-Dependent Protein Kinases
2017
81 Citations (Scopus)

Cysteinyl-tRNA synthetase governs cysteine polysulfidation and mitochondrial bioenergetics

Akaike, T., Ida, T., Wei, F. Y., Nishida, M., Kumagai, Y., Alam, M. M., Ihara, H., Sawa, T., Matsunaga, T., Kasamatsu, S., Nishimura, A., Morita, M., Tomizawa, K., Nishimura, A., Watanabe, S., Inaba, K., Shima, H., Tanuma, N., Jung, M., Fujii, S. & 6 others, Watanabe, Y., Ohmuraya, M., Nagy, P., Feelisch, M., Fukuto, J. M. & Motohashi, H., Dec 1 2017, In : Nature communications. 8, 1, 1177.

Research output: Contribution to journalArticle

cysteinyl-tRNA synthetase
cysteine
Energy Metabolism
Cysteine
Cysteine Synthase
1 Citation (Scopus)

Eco-pharma of approved drug focused on mitochondria fission

Shimauchi, T., Nishimura, A., Ishikawa, T. & Nishida, M., Jan 1 2017, In : Folia Pharmacologica Japonica. 149, 6, p. 269-273 5 p.

Research output: Contribution to journalComment/debate

Drug Repositioning
Mitochondrial Dynamics
Drug Approval
Cell Aging
Mitochondria
5 Citations (Scopus)

Purinergic P2Y6 receptors: A new therapeutic target of age-dependent hypertension

Sunggip, C., Nishimura, A., Shimoda, K., Numaga-Tomita, T., Makoto, T. & Nishida, M., Jun 1 2017, In : Pharmacological Research. 120, p. 51-59 9 p.

Research output: Contribution to journalReview article

Purinergic Receptors
Hypertension
Angiotensin Type 1 Receptor
clopidogrel
Purinergic P2Y12 Receptors
17 Citations (Scopus)

Purinergic P2Y receptors: Molecular diversity and implications for treatment of cardiovascular diseases

Nishimura, A., Sunggip, C., Oda, S., Numaga-Tomita, T., Makoto, T. & Nishida, M., Dec 1 2017, In : Pharmacology and Therapeutics. 180, p. 113-128 16 p.

Research output: Contribution to journalReview article

Purinergic P2Y Receptors
G-Protein-Coupled Receptors
Cardiovascular System
Cardiovascular Diseases
Uracil Nucleotides

Purinergic signaling in cardiovascular system

Nishimura, A. & Nishida, M., Jan 1 2017, In : Folia Pharmacologica Japonica. 149, 2, p. 84-90 7 p.

Research output: Contribution to journalArticle

Uracil
Cardiovascular System
Adenosine
Signal Transduction
Hypertension
6 Citations (Scopus)

Redox regulation of electrophilic signaling by reactive persulfides in cardiac cells

Nishida, M., Nishimura, A., Matsunaga, T., Motohashi, H., Kasamatsu, S. & Akaike, T., Aug 1 2017, In : Free Radical Biology and Medicine. 109, p. 132-140 9 p.

Research output: Contribution to journalReview article

Metabolism
Oxidation-Reduction
Nitric Oxide
Cardiovascular Physiological Phenomena
Cell signaling
18 Citations (Scopus)

Stimulation of adenosine A2B receptor inhibits endothelin-1-induced cardiac Fibroblast proliferation and α-smooth muscle actin synthesis through the cAMP/Epac/PI3K/Akt-signaling pathway

Phosri, S., Arieyawong, A., Bunrukchai, K., Parichatikanond, W., Nishimura, A., Nishida, M. & Mangmool, S., Jun 30 2017, In : Frontiers in Pharmacology. 8, JUN, 428.

Research output: Contribution to journalArticle

Endothelin A Receptors
Phosphatidylinositol 3-Kinases
Adenosine
Endothelin-1
Smooth Muscle
8 Citations (Scopus)

TRPC3-Nox2 complex mediates doxorubicin-induced myocardial atrophy

Shimauchi, T., Numaga-Tomita, T., Ito, T., Nishimura, A., Matsukane, R., Oda, S., Hoka, S., Ide, T., Koitabashi, N., Uchida, K., Sumimoto, H., Mori, Y. & Nishida, M., Aug 3 2017, In : JCI insight. 2, 15

Research output: Contribution to journalArticle

Open Access
NADPH Oxidase
Doxorubicin
Atrophy
Cardiac Myocytes
Compliance
3 Citations (Scopus)

TRPC6 counteracts TRPC3-Nox2 protein complex leading to attenuation of hyperglycemia-induced heart failure in mice

Oda, S., Numaga-Tomita, T., Kitajima, N., Toyama, T., Harada, E., Shimauchi, T., Nishimura, A., Ishikawa, T., Kumagai, Y., Birnbaumer, L. & Nishida, M., Dec 1 2017, In : Scientific reports. 7, 1, 7511.

Research output: Contribution to journalArticle

NADPH Oxidase
Hyperglycemia
Heart Failure
Proteins
Reactive Oxygen Species
2016
28 Citations (Scopus)

Purinergic P2Y6 receptors heterodimerize with angiotensin AT1 receptors to promote angiotensin II-induced hypertension

Nishimura, A., Sunggip, C., Saitoh, H., Shimauchi, T., Numaga-Tomita, T., Hirano, K., Ide, T., Boeynaems, J. M., Kurose, H., Makoto, T., Robaye, B., Inoue, K. & Nishida, M., Jan 19 2016, In : Science Signaling. 9, 411, aac9187.

Research output: Contribution to journalArticle

Purinergic Receptors
Angiotensin Type 1 Receptor
Angiotensin II
Hypertension
Arrestin
18 Citations (Scopus)

TRPC3-GEF-H1 axis mediates pressure overload-induced cardiac fibrosis

Numaga-Tomita, T., Kitajima, N., Kuroda, T., Nishimura, A., Miyano, K., Yasuda, S., Kuwahara, K., Sato, Y., Ide, T., Birnbaumer, L., Sumimoto, H., Mori, Y. & Nishida, M., Dec 19 2016, In : Scientific reports. 6, 39383.

Research output: Contribution to journalArticle

Cardiac Myocytes
Fibrosis
Microtubules
Pressure
Fibroblasts
31 Citations (Scopus)

TRPC3 positively regulates reactive oxygen species driving maladaptive cardiac remodeling

Kitajima, N., Numaga-Tomita, T., Watanabe, M., Kuroda, T., Nishimura, A., Miyano, K., Yasuda, S., Kuwahara, K., Sato, Y., Ide, T., Birnbaumer, L., Sumimoto, H., Mori, Y. & Nishida, M., Nov 11 2016, In : Scientific reports. 6, 37001.

Research output: Contribution to journalArticle

NADPH Oxidase
Reactive Oxygen Species
Physiological Adaptation
Proteasome Endopeptidase Complex
Cardiac Myocytes
2015
18 Citations (Scopus)

Divergent roles of CAAX motif-signaled posttranslational modifications in the regulation and subcellular localization of Ral GTPases

Gentry, L. R., Nishimura, A., Cox, A. D., Martin, T. D., Tsygankov, D., Nishida, M., Elston, T. C. & Der, C. J., Sep 11 2015, In : Journal of Biological Chemistry. 290, 37, p. 22851-22861 11 p.

Research output: Contribution to journalArticle

Endopeptidases
GTP Phosphohydrolases
Post Translational Protein Processing
Protein Isoforms
Cell Membrane
3 Citations (Scopus)

Light-dependent activation of G proteins by two isoforms of chicken melanopsins

Torii, M., Kojima, D., Nishimura, A., Itoh, H. & Fukada, Y., Jan 1 2015, In : Photochemical and Photobiological Sciences. 14, 11, p. 1991-1997 7 p.

Research output: Contribution to journalArticle

chickens
pineal gland
GTP-Binding Proteins
Opsins
Protein Isoforms
2013

[New research initiatives in the regulatory mechanisms of heterotrimeric G protein signaling].

Itoh, H., Nishimura, A. & Nagai, Y., Jan 1 2013, In : Unknown Journal. 85, 7, p. 531-542 12 p.

Research output: Contribution to journalReview article

Heterotrimeric GTP-Binding Proteins
Biological Models
G-Protein-Coupled Receptors
Tertiary Protein Structure
Signal Transduction
41 Citations (Scopus)

Identification of a novel prenyl and palmitoyl modification at the CaaX motif of Cdc42 that regulates RhoGDI binding

Nishimura, A. & Linder, M. E., Apr 1 2013, In : Molecular and cellular biology. 33, 7, p. 1417-1429 13 p.

Research output: Contribution to journalArticle

Lipoylation
Prenylation
Cysteine
Palmitates
GTP Phosphohydrolases
2011
15 Citations (Scopus)

Plasma membrane association of p63 Rho guanine nucleotide exchange factor (p63RhoGEF) is mediated by palmitoylation and is required for basal activity in cells

Aittaleb, M., Nishimura, A., Linder, M. E. & Tesmer, J. J. G., Oct 30 2011, In : Journal of Biological Chemistry. 286, 39, p. 34448-34456 9 p.

Research output: Contribution to journalArticle

Rho Guanine Nucleotide Exchange Factors
Lipoylation
Cell membranes
Cell Membrane
Association reactions
2010
37 Citations (Scopus)

Ric-8B stabilizes the α subunit of stimulatory G protein by inhibiting its ubiquitination

Nagai, Y., Nishimura, A., Tago, K., Mizuno, N. & Itoh, H., Apr 9 2010, In : Journal of Biological Chemistry. 285, 15, p. 11114-11120 7 p.

Research output: Contribution to journalArticle

Ubiquitination
Cholinesterase Inhibitors
GTP-Binding Proteins
Proteins
Ubiquitinated Proteins
100 Citations (Scopus)

Structural basis for the specific inhibition of heterotrimeric G q protein by a small molecule

Nishimura, A., Kitano, K., Takasaki, J., Taniguchi, M., Mizuno, N., Tago, K., Hakoshima, T. & Itoh, H., Aug 3 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 31, p. 13666-13671 6 p.

Research output: Contribution to journalArticle

Heterotrimeric GTP-Binding Proteins
GTP-Binding Proteins
G-Protein-Coupled Receptors
Gq-G11 GTP-Binding Protein alpha Subunits
Depsipeptides
2006
38 Citations (Scopus)

Ric-8A potentiates Gq-mediated signal transduction by acting downstream of G protein-coupled receptor in intact cells

Nishimura, A., Okamoto, M., Sugawara, Y., Mizuno, N., Yamauchi, J. & Itoh, H., May 1 2006, In : Genes to Cells. 11, 5, p. 487-498 12 p.

Research output: Contribution to journalArticle

G-Protein-Coupled Receptors
Signal Transduction
Guanine Nucleotide Exchange Factors
Two-Hybrid System Techniques
Guanine Nucleotides
2005
28 Citations (Scopus)

G protein-coupled receptor signaling through Gq and JNK negatively regulates neural progenitor cell migration

Mizuno, N., Kokubu, H., Sato, M., Nishimura, A., Yamauchi, J., Kurose, H. & Itoh, H., Aug 30 2005, In : Proceedings of the National Academy of Sciences of the United States of America. 102, 35, p. 12365-12370 6 p.

Research output: Contribution to journalArticle

G-Protein-Coupled Receptors
Cell Movement
Phosphotransferases
Stem Cells
Endothelin-1