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Research Output 1999 2019

  • 2825 Citations
  • 23 h-Index
  • 40 Article
  • 8 Review article
  • 1 Comment/debate
2019

Zfp281 Shapes the Transcriptome of Trophoblast Stem Cells and Is Essential for Placental Development

Ishiuchi, T., Ohishi, H., Sato, T., Kamimura, S., Yorino, M., Abe, S., Suzuki, A., Wakayama, T., Suyama, M. & Sasaki, H., May 7 2019, In : Cell Reports. 27, 6, p. 1742-1754.e6

Research output: Contribution to journalArticle

Open Access
Placentation
Trophoblasts
Stem cells
Transcriptome
Stem Cells
2018
4 Citations (Scopus)

Brief summary of the current protocols for generating intestinal organoids

Miura, S. & Suzuki, A., Aug 1 2018, In : Development Growth and Differentiation. 60, 6, p. 387-392 6 p.

Research output: Contribution to journalReview article

Organoids
Intestinal Diseases
Epithelial Cells
Intestines
Food
2 Citations (Scopus)

Cell Aggregation Culture Induces Functional Differentiation of Induced Hepatocyte-like Cells through Activation of Hippo Signaling

Yamamoto, J., Udono, M., Miura, S., Sekiya, S. & Suzuki, A., Oct 2 2018, In : Cell Reports. 25, 1, p. 183-198 16 p.

Research output: Contribution to journalArticle

Cell Aggregation
Hepatocytes
Agglomeration
Cell Culture Techniques
Chemical activation
3 Citations (Scopus)

Prolonged inhibition of hepatocellular carcinoma cell proliferation by combinatorial expression of defined transcription factors

Takashima, Y., Horisawa, K., Udono, M., Ohkawa, Y. & Suzuki, A., Nov 1 2018, In : Cancer Science. 109, 11, p. 3543-3553 11 p.

Research output: Contribution to journalArticle

Hepatocellular Carcinoma
Transcription Factor 3
Transcription Factors
Cell Proliferation
Cell Line
2017
1 Citation (Scopus)

Cell fate modification toward the hepatic lineage by extrinsic factors

Kawamata, M. & Suzuki, A., Jul 1 2017, In : Journal of Biochemistry. 162, 1, p. 11-16 6 p.

Research output: Contribution to journalReview article

Stem cells
Liver
Hepatocytes
Induced Pluripotent Stem Cells
Fibroblasts
8 Citations (Scopus)

Chd2 regulates chromatin for proper gene expression toward differentiation in mouse embryonic stem cells

Semba, Y., Harada, A., Maehara, K., Oki, S., Meno, C., Ueda, J., Yamagata, K., Suzuki, A., Onimaru, M., Nogami, J., Okada, S., Akashi, K. & Ohkawa, Y., Sep 1 2017, In : Nucleic acids research. 45, 15, p. 8758-8772 15 p.

Research output: Contribution to journalArticle

DNA Helicases
Embryonic Stem Cells
Chromatin
Gene Expression
Histones
10 Citations (Scopus)

Generation of Mouse and Human Organoid-Forming Intestinal Progenitor Cells by Direct Lineage Reprogramming

Miura, S. & Suzuki, A., Oct 5 2017, In : Cell stem cell. 21, 4, p. 456-471.e5

Research output: Contribution to journalArticle

Organoids
Cell Lineage
Stem Cells
Intestines
Transcription Factors
2016
3 Citations (Scopus)

Kupffer cells induce Notch-mediated hepatocyte conversion in a common mouse model of intrahepatic cholangiocarcinoma

Terada, M., Horisawa, K., Miura, S., Takashima, Y., Ohkawa, Y., Sekiya, S., Matsuda-Ito, K. & Suzuki, A., Oct 4 2016, In : Scientific reports. 6, 34691.

Research output: Contribution to journalArticle

Kupffer Cells
Cholangiocarcinoma
Hepatocytes
Liver
Intrahepatic Bile Ducts
4 Citations (Scopus)

Myofibroblasts Derived from Hepatic Progenitor Cells Create the Tumor Microenvironment

Sekiya, S., Miura, S., Matsuda-Ito, K. & Suzuki, A., Dec 13 2016, In : Stem Cell Reports. 7, 6, p. 1130-1139 10 p.

Research output: Contribution to journalArticle

Tumor Microenvironment
Myofibroblasts
Tumors
Hepatocytes
Stem Cells
1 Citation (Scopus)

Novel methods for the treatment of liver fibrosis using in vivo direct reprogramming technology

Goya, T. & Suzuki, A., Jan 1 2016, In : Stem Cell Investigation. 2016, DEC, 92.

Research output: Contribution to journalComment/debate

Liver Cirrhosis
Technology
24 Citations (Scopus)

Suppression of lethal-7b and miR-125a/b Maturation by Lin28b Enables Maintenance of Stem Cell Properties in Hepatoblasts

Takashima, Y., Terada, M., Udono, M., Miura, S., Yamamoto, J. & Suzuki, A., Jul 1 2016, In : Hepatology. 64, 1, p. 245-260 16 p.

Research output: Contribution to journalArticle

MicroRNAs
Stem Cells
Maintenance
Hepatocytes
Liver
2015
23 Citations (Scopus)

Dynamic three-dimensional morphogenesis of intrahepatic bile ducts in mouse liver development

Takashima, Y., Terada, M., Kawabata, M. & Suzuki, A., Mar 1 2015, In : Hepatology. 61, 3, p. 1003-1011 9 p.

Research output: Contribution to journalArticle

Intrahepatic Bile Ducts
Morphogenesis
Liver
Portal Vein
Spatio-Temporal Analysis
6 Citations (Scopus)
Hepatocytes
Liver
Cell Tracking
Cell Lineage
Tamoxifen
4 Citations (Scopus)

MBSJ MCC young scientist award 2012 liver regeneration: A unique and flexible reaction depending on the type of injury

Suzuki, A., Feb 1 2015, In : Genes to Cells. 20, 2, p. 77-84 8 p.

Research output: Contribution to journalReview article

Liver Regeneration
Liver
Wounds and Injuries
Hepatocytes
Living Donors
2014
2 Citations (Scopus)
Open Access
Hepatocytes
Fibroblasts
Fatty Liver
Lipids
Preclinical Drug Evaluations
55 Citations (Scopus)

Hepatocytes, rather than cholangiocytes, can be the major source of primitive ductules in the chronically injured mouse liver

Sekiya, S. & Suzuki, A., Jan 1 2014, In : American Journal of Pathology. 184, 5, p. 1468-1478 11 p.

Research output: Contribution to journalArticle

Hepatocytes
Liver
Liver Diseases
Liver Regeneration
Liver Neoplasms
2013
5 Citations (Scopus)

Artificial induction and disease-related conversion of the hepatic fate

Suzuki, A., Oct 1 2013, In : Current Opinion in Genetics and Development. 23, 5, p. 579-584 6 p.

Research output: Contribution to journalReview article

Hepatocytes
Liver
Liver Diseases
Transcription Factors
Tissue Transplantation
15 Citations (Scopus)

Regulation of organogenesis and stem cell properties by T-box transcription factors

Takashima, Y. & Suzuki, A., Oct 1 2013, In : Cellular and Molecular Life Sciences. 70, 20, p. 3929-3945 17 p.

Research output: Contribution to journalReview article

Organogenesis
Transcription Factors
Stem Cells
Induced Pluripotent Stem Cells
Regenerative Medicine
23 Citations (Scopus)

Transcription factors interfering with dedifferentiation induce cell type-specific transcriptional profiles

Hikichi, T., Matoba, R., Ikeda, T., Watanabe, A., Yamamoto, T., Yoshitake, S., Tamura-Nakano, M., Kimura, T., Kamon, M., Shimura, M., Kawakami, K., Okuda, A., Okochi, H., Inoue, T., Suzuki, A. & Masui, S., Apr 16 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 16, p. 6412-6417 6 p.

Research output: Contribution to journalArticle

Cell Dedifferentiation
Transcription Factors
Hepatocytes
Maintenance
Cell Line
2012
1 Citation (Scopus)
Hepatocyte Nuclear Factor 3-gamma
Hepatocyte Nuclear Factor 3-alpha
Hepatocyte Nuclear Factor 6
Hepatocyte Nuclear Factor 3-beta
Tumor Suppressor Proteins
175 Citations (Scopus)

Intrahepatic cholangiocarcinoma can arise from Notch-mediated conversion of hepatocytes

Sekiya, S. & Suzuki, A., Nov 1 2012, In : Journal of Clinical Investigation. 122, 11, p. 3914-3918 5 p.

Research output: Contribution to journalArticle

Cholangiocarcinoma
Hepatocytes
Neoplasms
Hepatitis
Liver
2011
511 Citations (Scopus)

Direct conversion of mouse fibroblasts to hepatocyte-like cells by defined factors

Sekiya, S. & Suzuki, A., Jul 21 2011, In : Nature. 475, 7356, p. 390-395 6 p.

Research output: Contribution to journalArticle

Hepatocytes
Fibroblasts
Tissue Transplantation
Liver
Liver Transplantation
71 Citations (Scopus)

Fbxw7 regulates lipid metabolism and cell fate decisions in the mouse liver

Onoyama, I., Suzuki, A., Matsumoto, A., Tomita, K., Katagiri, H., Oike, Y., Nakayama, K. & Nakayama, K., Jan 4 2011, In : Journal of Clinical Investigation. 121, 1, p. 342-354 13 p.

Research output: Contribution to journalArticle

Lipid Metabolism
F-Box Proteins
Liver
Biliary Tract
S-Phase Kinase-Associated Proteins
23 Citations (Scopus)
Glycogen Synthase Kinase 3
Liver Regeneration
Snails
Hepatocytes
Liver
2010
34 Citations (Scopus)

EGF signaling activates proliferation and blocks apoptosis of mouse and human intestinal stem/progenitor cells in long-term monolayer cell culture

Suzuki, A., Sekiya, S., Gunshima, E., Fujii, S. & Taniguchi, H., Oct 1 2010, In : Laboratory Investigation. 90, 10, p. 1425-1436 12 p.

Research output: Contribution to journalArticle

Epidermal Growth Factor
Stem Cells
Cell Culture Techniques
Apoptosis
Epithelial Cells
2008
114 Citations (Scopus)

Flow cytometric isolation and clonal identification of self-renewing bipotent hepatic progenitor cells in adult mouse liver

Suzuki, A., Sekiya, S., Onishi, M., Oshima, N., Kiyonari, H., Nakauchi, H. & Taniguchi, H., Dec 1 2008, In : Hepatology. 48, 6, p. 1964-1978 15 p.

Research output: Contribution to journalArticle

Hepatocytes
Stem Cells
Liver
Liver Regeneration
Single-Cell Analysis
80 Citations (Scopus)

Tbx3 controls the fate of hepatic progenitor cells in liver development by suppressing p19ARF expression

Suzuki, A., Sekiya, S., Büscher, D., Belmonte, J. C. I. & Taniguchi, H., May 1 2008, In : Development. 135, 9, p. 1589-1595 7 p.

Research output: Contribution to journalArticle

Hepatocytes
Stem Cells
Liver
Organogenesis
Cell Differentiation
2007
109 Citations (Scopus)

Isolation of Mouse Pancreatic Ductal Progenitor Cells Expressing CD133 and c-Met by Flow Cytometric Cell Sorting

Oshima, Y., Suzuki, A., Kawashimo, K., Ishikawa, M., Ohkohchi, N. & Taniguchi, H., Jan 1 2007, In : Gastroenterology. 132, 2, p. 720-732 13 p.

Research output: Contribution to journalArticle

Stem Cells
Epithelium
Regeneration
Islets of Langerhans Transplantation
Cell Separation
2006
54 Citations (Scopus)

Maintenance of embryonic stem cell pluripotency by Nanog-mediated reversal of mesoderm specification

Suzuki, A., Raya, Á., Kawakami, Y., Morita, M., Matsui, T., Nakashima, K., Gage, F. H., Rodríguez-Esteban, C. & Izpiśa Belmonte, J. C., Mar 1 2006, In : Nature Clinical Practice Cardiovascular Medicine. 3, SUPPL. 1

Research output: Contribution to journalArticle

Mesoderm
Embryonic Stem Cells
Maintenance
Leukemia Inhibitory Factor
Bone Morphogenetic Proteins
192 Citations (Scopus)

Nanog binds to Smad1 and blocks bone morphogenetic protein-induced differentiation of embryonic stem cells

Suzuki, A., Raya, Á., Kawakami, Y., Morita, M., Matsui, T., Nakashima, K., Gage, F. H., Rodríguez-Esteban, C. & Belmonte, J. C. I., Jul 4 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 27, p. 10294-10299 6 p.

Research output: Contribution to journalArticle

Bone Morphogenetic Proteins
Embryonic Stem Cells
Leukemia Inhibitory Factor
Regenerative Medicine
Mesoderm
2004
30 Citations (Scopus)

Liver repopulation by c-Met-positive stem/progenitor cells isolated from the developing rat liver

Suzuki, A., Zheng, Y. W., Fukao, K., Nakauchi, H. & Taniguchi, H., Mar 2004, In : Hepato-Gastroenterology. 51, 56, p. 423-426 4 p.

Research output: Contribution to journalArticle

Stem Cells
Liver
Hepatocytes
Flow Cytometry
Proto-Oncogene Proteins c-met
191 Citations (Scopus)

Prospective isolation of multipotent pancreatic progenitors using flow-cytometric cell sorting

Suzuki, A., Nakauchi, H. & Taniguchi, H., Aug 1 2004, In : Diabetes. 53, 8, p. 2143-2152 10 p.

Research output: Contribution to journalArticle

Stem Cells
Pancreas
Acinar Cells
Proto-Oncogene Proteins c-met
Antigens
2003
112 Citations (Scopus)

Glucagon-like peptide 1 (1-37) converts intestinal epithelial cells into insulin-producing cells

Suzuki, A., Nakauchi, H. & Taniguchi, H., Apr 29 2003, In : Proceedings of the National Academy of Sciences of the United States of America. 100, 9, p. 5034-5039 6 p.

Research output: Contribution to journalArticle

Epithelial Cells
Insulin
Proglucagon
Glucagon-Like Peptide 1
Pancreas
26 Citations (Scopus)

In vitro production of functionally mature hepatocytes from prospectively isolated hepatic stem cells

Suzuki, A., Nakauchi, H. & Taniguchi, H., Jan 1 2003, In : Cell Transplantation. 12, 5, p. 469-473 5 p.

Research output: Contribution to journalArticle

Stem cells
Hepatocytes
Stem Cells
Liver
Artificial Organs
149 Citations (Scopus)

Role for growth factors and extracellular matrix in controlling differentiation of prospectively isolated hepatic stem cells

Suzuki, A., Iwana, A., Miyashita, H., Nakauchi, H. & Taniguchi, H., Jun 2003, In : Development. 130, 11, p. 2513-2524 12 p.

Research output: Contribution to journalArticle

Extracellular Matrix
Hepatocytes
Intercellular Signaling Peptides and Proteins
Stem Cells
Liver
2002
310 Citations (Scopus)

Clonal identification and characterization of self-renewing pluripotent stem cells in the developing liver

Suzuki, A., Zheng, Y. W., Kaneko, S., Onodera, M., Fukao, K., Nakauchi, H. & Taniguchi, H., Jan 7 2002, In : Journal of Cell Biology. 156, 1, p. 173-184 12 p.

Research output: Contribution to journalArticle

Pluripotent Stem Cells
Hepatocytes
Liver
Stem Cells
Digestive System Diseases
18 Citations (Scopus)

Establishment of clonal colony-forming assay system for pancreatic stem/progenitor cells

Suzuki, A., Oyama, K., Fukao, K., Nakauchi, H. & Taniguchi, H., Oct 16 2002, In : Cell Transplantation. 11, 5, p. 451-453 3 p.

Research output: Contribution to journalArticle

Stem cells
Assays
Stem Cells
Cell culture
Cells
70 Citations (Scopus)

Evidence for hepatocyte differentiation from embryonic stem cells in vitro

Miyashita, H., Suzuki, A., Fukao, K., Nakauchi, H. & Taniguchi, H., 2002, In : Cell Transplantation. 11, 5, p. 429-434 6 p.

Research output: Contribution to journalArticle

Embryonic Stem Cells
Stem cells
Hepatocytes
Liver
Embryoid Bodies
23 Citations (Scopus)

Identification and propagation of liver stem cells

Suzuki, A. & Nakauchi, H., Jan 1 2002, In : Seminars in Cell and Developmental Biology. 13, 6, p. 455-461 7 p.

Research output: Contribution to journalReview article

Stem Cells
Liver
Hepatocytes
Digestive System Diseases
Acinar Cells
2001
12 Citations (Scopus)

Clonal expansion of hepatic stem/progenitor cells following flow cytometric cell sorting

Suzuki, A., Zheng, Y. W., Fukao, K., Nakauchi, H. & Taniguchi, H., 2001, In : Cell Transplantation. 10, 4-5, p. 393-396 4 p.

Research output: Contribution to journalArticle

Stem cells
Sorting
Hepatocytes
Stem Cells
Cells
7 Citations (Scopus)

Hepatic stem/progenitor cells with high proliferative potential in liver organ formation

Suzuki, A., Zheng, Y. W., Fukao, K., Nakauchi, H. & Taniguchi, H., Apr 5 2001, In : Transplantation Proceedings. 33, 1-2, p. 585-586 2 p.

Research output: Contribution to journalArticle

Inbred BALB C Mouse
Colony-Forming Units Assay
Age Factors
Cell Division
Hepatocytes
2000
8 Citations (Scopus)

Clonal colony formation of hepatic stem/progenitor cells enhanced by embryonic fibroblast conditioning medium

Suzuki, A., Taniguchi, H., Zheng, Y. W., Takada, Y., Fukunaga, K., Seino, K., Yazawa, K., Otsuka, M., Fukao, K. & Nakauchi, H., Dec 23 2000, In : Transplantation Proceedings. 32, 7, p. 2328-2330 3 p.

Research output: Contribution to journalArticle

Colony-Forming Units Assay
DNA Primers
Conditioned Culture Medium
Hematopoietic Stem Cells
Inbred C57BL Mouse
14 Citations (Scopus)

Clonogenic colony-forming ability of flow cytometrically isolated hepatic progenitor cells in the murine fetal liver

Taniguchi, H., Kondo, R., Suzuki, A., Zheng, Y. W., Takada, Y., Fukunaga, K., Seino, K. I., Yuzawa, K., Otsuka, M., Fukao, K. & Nakauchi, H., Jan 1 2000, In : Cell Transplantation. 9, 5, p. 697-700 4 p.

Research output: Contribution to journalArticle

Liver
Hepatocytes
Stem cells
Stem Cells
Fluorescence
5 Citations (Scopus)

Effects of combined growth factors on clonal growth and albumin secretion of murine fetal hepatocytes in low density culture

Zheng, Y. W., Taniguchi, H., Suzuki, A., Takada, Y., Fukunaga, K., Seino, K., Yuzawa, K., Otsuka, M., Fukao, K. & Nakauchi, H., Dec 23 2000, In : Transplantation Proceedings. 32, 7, p. 2372-2373 2 p.

Research output: Contribution to journalArticle

Inbred BALB C Mouse
Oncostatin M
Growth Substances
Transforming Growth Factor alpha
Hepatocyte Growth Factor
4 Citations (Scopus)

Effects of four extracellular matrices associated with growth factors on clonal culture and proliferation of murine fetal hepatocytes

Zheng, Y. W., Taniguchi, H., Suzuki, A., Takada, Y., Fukunaga, K., Seino, K., Yuzawa, K., Otsuka, M., Fukao, K. & Nakauchi, H., Dec 23 2000, In : Transplantation Proceedings. 32, 7, p. 2498-2499 2 p.

Research output: Contribution to journalArticle

Inbred BALB C Mouse
Oncostatin M
Growth Substances
Transforming Growth Factor alpha
Hepatocyte Growth Factor
262 Citations (Scopus)

Flow-cytometric separation and enrichment of hepatic progenitor cells in the developing mouse liver

Suzuki, A., Zheng, Y. W., Kondo, R., Kusakabe, M., Takada, Y., Fukao, K., Nakauchi, H. & Taniguchi, H., Jan 1 2000, In : Hepatology. 32, 6, p. 1230-1239 10 p.

Research output: Contribution to journalArticle

Hepatocytes
Stem Cells
Liver
Integrin alpha6beta1
Flow Cytometry
5 Citations (Scopus)

Proliferative and functional ability of transplanted murine neonatal hepatocytes in adult livers

Suzuki, A., Taniguchi, H., Zheng, Y. W., Takada, Y., Fukunaga, K., Seino, K., Yazawa, K., Otsuka, M., Yoshiki, A., Kusakabe, M., Fukao, K. & Nakauchi, H., Dec 23 2000, In : Transplantation Proceedings. 32, 7, p. 2370-2371 2 p.

Research output: Contribution to journalArticle

Inbred BALB C Mouse
Newborn Animals
Heterologous Transplantation
Inbred C3H Mouse
Cell Transplantation
15 Citations (Scopus)

Usefulness of flow-cytometric cell sorting for enrichment of hepatic stem and progenitor cells in the liver

Taniguchi, H., Suzuki, A., Zheng, Y., Kondo, R., Takada, Y., Fukunaga, K., Seino, K., Yuzawa, K., Otsuka, M., Fukao, K. & Nakauchi, H., Mar 1 2000, In : Transplantation Proceedings. 32, 2, p. 249-251 3 p.

Research output: Contribution to journalArticle

Inbred BALB C Mouse
Colony-Forming Units Assay
Hypoxanthine Phosphoribosyltransferase
Hepatocyte Growth Factor
Cell Separation
1999
7 Citations (Scopus)

Evidence for the presence of hepatic stem cells in the murine fetal liver

Taniguchi, H., Kondo, R., Suzuki, A., Zheng, Y., Ito, S., Takada, Y., Fukunaga, K., Seino, K., Yuzawa, K., Otsuka, M., Fukao, K., Yoshiki, A., Kusakabe, M. & Nakauchi, H., Feb 1 1999, In : Transplantation Proceedings. 31, 1-2, 1 p.

Research output: Contribution to journalArticle

Inbred BALB C Mouse
CD45 Antigens
Reverse Transcriptase Polymerase Chain Reaction
Cell Division
Gestational Age