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Research Output

  • 1309 Citations
  • 16 h-Index
  • 105 Chapter (peer-reviewed)
  • 39 Article
  • 3 Review article
  • 1 Poster
2020
1 Citation (Scopus)

Evaluation of the Influence of Halogenation on the Binding of Bisphenol A to the Estrogen-Related Receptor γ

Suyama, K., Kaneko, S., Kesamaru, H., Liu, X., Matsushima, A., Kakuta, Y., Okubo, T., Kasatani, K. & Nose, T., Apr 20 2020, In : Chemical Research in Toxicology. 33, 4, p. 889-902 14 p.

Research output: Contribution to journalArticle

2019

Biosynthetic Short Neuropeptides: A Rational Theory Based on Experimental Results for the Missing Pain-Relief Opioid Endomorphin Precursor Gene

Matsushima, A., Sese, J. & Koyanagi, K. O., Jan 1 2019, In : ChemBioChem. 20, 16, p. 2054-2058 5 p.

Research output: Contribution to journalArticle

Discovery of novel oestrogen receptor α agonists and antagonists by screening a revisited privileged structure moiety for nuclear receptors

Masuya, T., Iwamoto, M., Liu, X. & Matsushima, A., Dec 1 2019, In : Scientific reports. 9, 1, 9954.

Research output: Contribution to journalArticle

Open Access

Evaluation of the binding ability of an orphan nuclear receptor nurr1 to synthetic peptides.

Masuya, T., Tada, Y., Liu, X. & Matsushima, A., 2019, Peptide Science 2018. p. 133

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Receptor-binding affinities of bisphenol A and its next-generation analogs for human nuclear receptors

Liu, X., Sakai, H., Nishigori, M., Suyama, K., Nawaji, T., Ikeda, S., Nishigouchi, M., Okada, H., Matsushima, A., Nose, T., Shimohigashi, M. & Shimohigashi, Y., Aug 15 2019, In : Toxicology and Applied Pharmacology. 377, 114610.

Research output: Contribution to journalArticle

6 Citations (Scopus)
2018
5 Citations (Scopus)

Homodimer function of human nuclear receptor ERR evidenced using -helix peptides in the dimer interface

Liu, X., Nakagawa, H., Sugiyama, M., Matsushima, A., Shimohigashi, M. & Shimohigashi, Y., 2018, Peptide Science 2017. p. 190 191 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Mutual co-work between nuclear receptor ERalpha and ERRgamma requires their homodimerization

Liu, X., Shimohigashi, M., Sugiyama, M., Matsushima, A. & Shimohigashi, Y., 2018, Peptide Science 2017,. p. 198 199 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Phe 2715.39 of Thronbin Receptor PAR-1 is a specific target of Phe-2-phenl group of its tethered ligand

Sugiyama, M., Fujita, T., Liu, X., Matsuyama, Y., Matsushima, A., Shimohigashi, M. & Shimohigashi, Y., 2018, Peptide Science 2017. p. 94 95 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

2017

Docking simulation to elucidate the labeled cysteine residue of the nociception receptor ORL1 using a Cys(Npys)-containing peptide ligand

Matsushima, A., Nishimura, H., Matsuyama, Y., Liu, X. & Shimohigashi, Y., 2017, Peptide Science 2016. p. 87-88

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

2016

Comparative analysis of the ligand binding domain secondary structures of human nuclear receptors

Matsuyama, Y., Nishimura, H., Liu, X., Matsushima, A. & Shimohigashi, Y., 2016, Peptide Science 2015. p. 337-338

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Comprehensive structural analysis of the nociceptin ORL1 receptor by means of virtual and experimental Ala-scanning combinated methods

Matsushima, A., Nishimura, H., Liu, X., Takesue, Y., Matsuyama, Y. & Shimohigashi, Y., 2016, Peptide Science 2015. p. 149-150

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Do the estrogen receptors function as a homodimer? experimental validation of homodimerization by inhibitory peptides

Sakito, S., Liu, X., Fujiyama, A., Matsushima, A. & Shimohigashi, Y., 2016, Peptide Science 2015. p. 335-336

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Do the estrogen receptors function as a homodimer? experimental validation of homodimerization by inhibitory peptides

Sakito, S., Fujiyama, A., Motomatsu, Y., Liu, X., Matsushima, A. & Shimohigashi, Y., 2016, Peptide Science 2015. p. 335-336

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Expression analysis of neuropeptide PDF mRNA in the hypoactive and hyperactive fruit flies Drosophila melanogaster

Asuka, T., Matsuo, A., Shotaro, U., Matsuyama, Y., masayuki, N., Sumiyoshi, M., Liu, X., Matsushima, A., Shimohigashi, M. & Shimohigashi, Y., 2016, Peptide Science 2015. p. 317-318

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Functional role of the Phe-Phe stacking microswitch in the ORL1 nociceptin receptor activation

Takesue, Y., Nishimura, H., Liu, X., Matsushima, A. & Shimohigashi, Y., 2016, Peptide Science 2015. p. 147-148

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

ORL1 Nociceptin receptor response of opioid peptides derived from proenkephalin precursor protein

Motomatsu, Y., Nishimura, H., Matsuyama, Y., Liu, X., Matsushima, A. & Shimohigashi, Y., 2016, Peptide Science 2015. p. 181-182

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

SCN Circadian rhythm signal transduction neuropeptides evoke hypoactive phenotype differently in male and female mice

Sugiyama, M., Motomatsu, Y., Matsuyama, Y., Kajiyama, S., Kameda, T., Uchimura, E., Saito, T., Liu, X., Matsushima, A. & Shimohigashi, Y., 2016, Peptide Science 2015. p. 53-54

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Specific affinity-labeling of the nociceptin ORL1 receptor using a thiol-activated Cys(Npys)-containing peptide ligand

Matsushima, A., Nishimura, H., Matsuyama, Y., Liu, X., Costa, T. & Shimohigashi, Y., Nov 4 2016, In : Biopolymers. p. 460-469 10 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Structure-function studies between the hormone-disrupting chemical bisphenols and the nuclear receptors

Matsushima, A., Jan 1 2016, In : Seikagaku. 88, 6, p. 733-743 11 p.

Research output: Contribution to journalReview article

α-Helix-peptides comprising the human nuclear receptor ERRγ competitively provoke inhibition of functional homomeric dimerization

Liu, X., Nishimura, H., Fujiyama, A., Matsushima, A., Shimohigashi, M. & Shimohigashi, Y., Nov 4 2016, In : Biopolymers. p. 547-554 8 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

核内受容体が示す有害化学物質ビスフェノール応答

Translated title of the contribution: Structure-function studies between the hormone-disrupting chemical bisphenols and the nuclear receptorsMatsushima, A., Dec 2016, In : Seikagaku. The Journal of Japanese Biochemical Society. 88, 6, p. 733-43 11 p.

Research output: Contribution to journalArticle

2015

Alternative polyadenylation analyses of neuropeptide genes in bisphenol A-exposed hypoactive mouse brain

Sugiyama, M., Kajiyama, S., Saito, T., Uchimura, E., Motomatsu, Y., Matsuo, A., Matsushima, A. & Shimohigashi, Y., 2015, Peptide Science 2014. p. 345-346

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

An in silico genomic search of endomorphin-like opioid peptides

Matsushima, A., Koyanagi, K. O., Nishimura, H., Inamine, S., Motomatsu, Y. & Shimohigashi, Y., 2015, Peptide Science 2014. p. 281-282

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

A novel method identify and quantify the coactivator proteins that couple with human nuclear receptor: the use of interacting interface a-helix peptide for quantitative inhibition

Liu, X., Matsushima, A. & Shimohigashi, Y., 2015, Peptide Science 2014. p. 203-204

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Bisphenol A-induced substantial peak decay of Drosophila circadian neuropeptide hugin mRNA expression

Shotaro, U., Matsuo, A., Matsuyama, Y., Nakamura, M., Koga, K., Liu, X., Matsushima, A., Shimohigashi, M. & Shimohigashi, Y., 2015, Peptide Science 2014. p. 41-42

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

GPCR functional role of Phe-269 and Phe-221 in the molecular switching of ORL1 nociceptin receptor activation

Takesue, Y., Nishimura, H., Liu, X., Matsushima, A. & Shimohigashi, Y., 2015, Peptide Science 2014. p. 203-204

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Receptor selectivity and specificity of a series of opioid peptides latent in the proenkephalin precursor protein

Motomatsu, Y., Nishimura, H., Matsumoto, Y., Kuramitsu, Y., Inamine, S., Matsushima, A. & Shimohigashi, Y., 2015, Peptide Science 2014. p. 201-202

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Structural and molecular evolutionary analysis of the ligand-binding domain of forty-eight human nuclear receptors

Matsuyama, Y., Nishimura, H., Liu, X., Matsushima, A. & Shimohigashi, Y., 2015, Peptide Science 2014. p. 347-348

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Structure-activity Studies on the Halogenated Phe-containing Neuropeptide Substance P Analogs

Kuramitsu, Y., Nishimura, H., Nakamura, M., Suyama, K., Matsushima, A., Nose, T. & Shimohigashi, Y., 2015, Peptide Science 2014. p. 319-320

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

The molecular switching of ORL1 nociceptin receptor in activation/inactivation

Nishimura, H., Li, J., Isozaki, K., yuuki, T., Matsushima, A., Liu, X., Shimohigashi, M. & Shimohigashi, Y., 2015, Peptide Science 2014. p. 201-202

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

2014

A characteristic back support structure in the bisphenol A-binding pocket in the human nuclear receptor ERRγ

Liu, X., Matsushima, A., Shimohigashi, M. & Shimohigashi, Y., Jun 30 2014, In : PloS one. 9, 6, e101252.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Bisphenol A-induced Epigenetic Mutations in Circadian Pacemaker Neuropeptide mRNAs of Hyperactive Drosophila Fruit Flies

Matsuo, A., Umeno, S., Matsuyama, Y., Nakamura, M., Takeda, Y., Sumiyoshi, M., Liu, X., Matsushima, A., Shimohigashi, M. & Shimohigashi, Y., 2014, Peptide Science 2013. p. 457-458

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Constitutive α-Helix-peptides Required for Functional Dimerization of Estrogen-related Receptor γ (ERRγ).

Liu, X., Nishimura, H., Fujiyama, A., Matsushima, A. & Shimohigashi, Y., 2014, Peptide Science 2013. p. 429-430

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Expression and Mutation Analyses of Brain Neuropeptide Genes of Rndocrine-disrupting Bisphenol A-exposed Hypoactive Mouse

Sugiyama, M., Matsuo, A., Saito, T., Uchimura, E., Liu, X., Matsushima, A. & Shimohigashi, Y., 2014, Peptide Science 2013. p. 453-454

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Functionally Essential Amino Acid Residues in ORL1 Nociceptin Receptor for Ligand-stimulated Receptor Activation

Nishimura, H., Li, J., abe, Y., Isozaki, K., Matsushima, A., Inamine, S., Costa, T. & Shimohigashi, Y., 2014, Peptide Science 2013. p. 333-334

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Influence Analysis of the Circadian Evening Pacemaker Neuropeptide hugγ Gene in the Bisphenol A-exposed Fruit Fly Drosophila Brain

Umeno, S., Matsuo, A., Matsuyama, Y., Nakamura, M., Takeda, Y., Sumiyoshi, M., Liu, X., Matsushima, A. & Shimohigashi, Y., 2014, Peptide Science 2013. p. 455-456

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Multiple and Simultaneous Cys→Ala Mutations of ORL1 Nociceptin Receptor to Identify the Affinity Binding site of Cys(Npys)-Elongated RYYRIK Peptide Antagonist

Matsushima, A., Nishimura, H., Inamine, S. & Shimohigashi, Y., 2014, Peptide Science 2013. p. 413-414

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

N-methylthioacetylation of RYYRIK-NH2 with enhanced specific binding affinity and high antagonist activity for nociceptin ORL1 receptor

Li, J., Nishimura, H., Matsushima, A. & Shimohigashi, Y., Nov 1 2014, In : Bioorganic and Medicinal Chemistry. 22, 21, p. 5721-5726 6 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Specific Role of Phe Residues in Opioid Peptide Met-enkephalin- Arg-Phe in Binding to All Three Opioid Receptors

Motomatsu, Y., Nishimura, H., Matsumoto, Y., Inamine, S., Kuramitsu, Y., Matsushima, A. & Shimohigashi, Y., 2014, Peptide Science 2013. p. 317-318

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Structure-Activity Studies on the Halogenated Phe-containing Neuropeptide Substance P Analogs

Kuramitsu, Y., Nishimura, H., Nakamura, R., Suyama, K., Matsushima, A., Nose, T. & Shimohigashi, Y., Mar 2014, Peptide Science 2013. p. 319-320 2 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Three-dimensional Docking Modeling to Human Nuclear Receptors for Exploration of Bisphenol-A Targeting Receptors

Matsuyama, Y., Liu, X., Nishimura, H., Matsushima, A. & Shimohigashi, Y., 2014, Peptide Science 2013. p. 459-460

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Tritium-labelled isovaleryl-RYYRIK-NH2 as potential antagonist probe for ORL1 nociceptin receptor

Inamine, S., Nishimura, H., Li, J., Isozaki, K., Matsushima, A., Costa, T. & Shimohigashi, Y., Nov 1 2014, In : Bioorganic and Medicinal Chemistry. 22, 21, p. 5902-5909 8 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)
2013

An endocrine disruptor, bisphenol A, affects development in the protochordate Ciona intestinalis: Hatching rates and swimming behavior alter in a dose-dependent manner

Matsushima, A., Ryan, K., Shimohigashi, Y. & Meinertzhagen, I. A., Feb 1 2013, In : Environmental Pollution. 173, p. 257-263 7 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Bisphenol-binding pocket of constitutively active nuclear receptor CAR: Docking modeling for close-packing

Matsuyama, Y., Liu, X., Nishimura, H., Matsushima, A., Nose, T. & Shimohigashi, Y., 2013, Peptide Science 2012. p. 401-402

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Exploration of pharmacological chaperone for rescue of misfolded and/or unfolded ORL1 nociceptin receptor proteins

Nishimura, H., Inamine, S., Li, J., Matsushima, A. & Shimohigashi, Y., 2013, Peptide Science 2012. p. 115-118

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Halogenated Phe-containing endomorphin-2 analogs with mixed agonist and antagonist activities

Nishio, K., Nishimura, H., Suyama, K., Matsushima, A., Nose, T. & Shimohigashi, Y., 2013, Peptide Science 2012. p. 25-26

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)