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Research Output

  • 1309 Citations
  • 16 h-Index
  • 105 Chapter (peer-reviewed)
  • 39 Article
  • 3 Review article
  • 1 Poster
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Article
2020
1 Citation (Scopus)

Evaluation of the Influence of Halogenation on the Binding of Bisphenol A to the Estrogen-Related Receptor γ

Suyama, K., Kaneko, S., Kesamaru, H., Liu, X., Matsushima, A., Kakuta, Y., Okubo, T., Kasatani, K. & Nose, T., Apr 20 2020, In : Chemical Research in Toxicology. 33, 4, p. 889-902 14 p.

Research output: Contribution to journalArticle

2019

Biosynthetic Short Neuropeptides: A Rational Theory Based on Experimental Results for the Missing Pain-Relief Opioid Endomorphin Precursor Gene

Matsushima, A., Sese, J. & Koyanagi, K. O., Jan 1 2019, In : ChemBioChem. 20, 16, p. 2054-2058 5 p.

Research output: Contribution to journalArticle

Discovery of novel oestrogen receptor α agonists and antagonists by screening a revisited privileged structure moiety for nuclear receptors

Masuya, T., Iwamoto, M., Liu, X. & Matsushima, A., Dec 1 2019, In : Scientific reports. 9, 1, 9954.

Research output: Contribution to journalArticle

Open Access

Receptor-binding affinities of bisphenol A and its next-generation analogs for human nuclear receptors

Liu, X., Sakai, H., Nishigori, M., Suyama, K., Nawaji, T., Ikeda, S., Nishigouchi, M., Okada, H., Matsushima, A., Nose, T., Shimohigashi, M. & Shimohigashi, Y., Aug 15 2019, In : Toxicology and Applied Pharmacology. 377, 114610.

Research output: Contribution to journalArticle

6 Citations (Scopus)
2016

Specific affinity-labeling of the nociceptin ORL1 receptor using a thiol-activated Cys(Npys)-containing peptide ligand

Matsushima, A., Nishimura, H., Matsuyama, Y., Liu, X., Costa, T. & Shimohigashi, Y., Nov 4 2016, In : Biopolymers. p. 460-469 10 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

α-Helix-peptides comprising the human nuclear receptor ERRγ competitively provoke inhibition of functional homomeric dimerization

Liu, X., Nishimura, H., Fujiyama, A., Matsushima, A., Shimohigashi, M. & Shimohigashi, Y., Nov 4 2016, In : Biopolymers. p. 547-554 8 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

核内受容体が示す有害化学物質ビスフェノール応答

Translated title of the contribution: Structure-function studies between the hormone-disrupting chemical bisphenols and the nuclear receptorsMatsushima, A., Dec 2016, In : Seikagaku. The Journal of Japanese Biochemical Society. 88, 6, p. 733-43 11 p.

Research output: Contribution to journalArticle

2014

A characteristic back support structure in the bisphenol A-binding pocket in the human nuclear receptor ERRγ

Liu, X., Matsushima, A., Shimohigashi, M. & Shimohigashi, Y., Jun 30 2014, In : PloS one. 9, 6, e101252.

Research output: Contribution to journalArticle

14 Citations (Scopus)

N-methylthioacetylation of RYYRIK-NH2 with enhanced specific binding affinity and high antagonist activity for nociceptin ORL1 receptor

Li, J., Nishimura, H., Matsushima, A. & Shimohigashi, Y., Nov 1 2014, In : Bioorganic and Medicinal Chemistry. 22, 21, p. 5721-5726 6 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Tritium-labelled isovaleryl-RYYRIK-NH2 as potential antagonist probe for ORL1 nociceptin receptor

Inamine, S., Nishimura, H., Li, J., Isozaki, K., Matsushima, A., Costa, T. & Shimohigashi, Y., Nov 1 2014, In : Bioorganic and Medicinal Chemistry. 22, 21, p. 5902-5909 8 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)
2013

An endocrine disruptor, bisphenol A, affects development in the protochordate Ciona intestinalis: Hatching rates and swimming behavior alter in a dose-dependent manner

Matsushima, A., Ryan, K., Shimohigashi, Y. & Meinertzhagen, I. A., Feb 1 2013, In : Environmental Pollution. 173, p. 257-263 7 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)
2012

Fine spatial assembly for construction of the phenol-binding pocket to capture bisphenol a in the human nuclear receptor estrogen-related receptor γ

Liu, X., Matsushima, A., Nakamura, M., Costa, T., Nose, T. & Shimohigashi, Y., Apr 1 2012, In : Journal of biochemistry. 151, 4, p. 403-415 13 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)
2011

Capturing of the free cysteine residue in the ligand-binding site by affinity labeling of the ORL1 nociceptin receptor

Matsushima, A., Nishimura, H., Inamine, S., Uemura, S. & Shimohigashi, Y., Dec 15 2011, In : Bioorganic and Medicinal Chemistry. 19, 24, p. 7597-7602 6 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Endocrine disrupter bisphenol a increases in situ estrogen production in the mouse urogenital sinus

Arase, S., Ishii, K., Igarashi, K., Aisaki, K., Yoshio, Y., Matsushima, A., Shimohigashi, Y., Arima, K., Kanno, J. & Sugimura, Y., Apr 1 2011, In : Biology of reproduction. 84, 4, p. 734-742 9 p.

Research output: Contribution to journalArticle

61 Citations (Scopus)

Pigment-dispersing factor affects nocturnal activity rhythms, photic entrainment, and the free-running period of the circadian clock in the cricket gryllus bimaculatus

Hassaneen, E., El-Din Sallam, A., Abo-Ghalia, A., Moriyama, Y., Karpova, S. G., Abdelsalam, S., Matsushima, A., Shimohigashi, Y. & Tomioka, K., Feb 1 2011, In : Journal of Biological Rhythms. 26, 1, p. 3-13 11 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)
2010

Bisphenol AF is a full agonist for the estrogen receptor ERα but a highly specific antagonist for ERβ

Matsushima, A., Liu, X., Okada, H., Shimohigashi, M. & Shimohigashi, Y., Sep 2010, In : Environmental Health Perspectives. 118, 9, p. 1267-1272 6 p.

Research output: Contribution to journalArticle

115 Citations (Scopus)

Distinction of the binding modes for human nuclear receptor ERRγ between bisphenol A and 4-hydroxytamoxifen

Liu, X., Matsushima, A., Okada, H. & Shimohigashi, Y., Aug 1 2010, In : Journal of biochemistry. 148, 2, p. 247-254 8 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)
2009

Discriminatory synergistic effect of Trp-substitutions in superagonist [(Arg/Lys)14, (Arg/Lys)15]nociceptin on ORL1 receptor binding and activation

Nishimura, H., Li, J., Isozaki, K., Okada, K., Matsushima, A., Nose, T., Costa, T. & Shimohigashi, Y., Aug 1 2009, In : Bioorganic and Medicinal Chemistry. 17, 15, p. 5683-5687 5 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Placenta expressing the greatest quantity of bisphenol A receptor ERRγ among the human reproductive tissues: Predominant expression of type-1 ERRγ isoform

Takeda, Y., Liu, X., Sumiyoshi, M., Matsushima, A., Shimohigashi, M. & Shimohigashi, Y., Jul 1 2009, In : Journal of biochemistry. 146, 1, p. 113-122 10 p.

Research output: Contribution to journalArticle

65 Citations (Scopus)

Spare interactions of highly potent [Arg14,Lys15]nociceptin for cooperative induction of ORL1 receptor activation

Isozaki, K., Li, J., Okada, K., Nishimura, H., Matsushima, A., Nose, T., Costa, T. & Shimohigashi, Y., Dec 1 2009, In : Bioorganic and Medicinal Chemistry. 17, 23, p. 7904-7908 5 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)
2008

Designed modification of partial agonist of ORL1 nociceptin receptor for conversion into highly potent antagonist

Li, J., Isozaki, K., Okada, K., Matsushima, A., Nose, T., Costa, T. & Shimohigashi, Y., Mar 1 2008, In : Bioorganic and Medicinal Chemistry. 16, 5, p. 2635-2644 10 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Direct evidence revealing structural elements essential for the high binding ability of bisphenol a to human estrogen-related receptor-γ

Okada, H., Tokunaga, T., Liu, X., Takayanagi, S., Matsushima, A. & Shimohigashi, Y., Jan 1 2008, In : Environmental Health Perspectives. 116, 1, p. 32-38 7 p.

Research output: Contribution to journalArticle

296 Citations (Scopus)

ERRγ tethers strongly bisphenol A and 4-α-cumylphenol in an induced-fit manner

Matsushima, A., Teramoto, T., Okada, H., Liu, X., Tokunaga, T., Kakuta, Y. & Shimohigashi, Y., Aug 29 2008, In : Biochemical and Biophysical Research Communications. 373, 3, p. 408-413 6 p.

Research output: Contribution to journalArticle

56 Citations (Scopus)

Radar chart deviation analysis of prion protein amino acid composition defines characteristic structural abnormalities of the N-terminal octapeptide tandem repeat

Yokotani, S., Nose, T., Horiuchi, Y., Matsushima, A. & Shimohigashi, Y., Sep 1 2008, In : Protein and Peptide Letters. 15, 9, p. 949-955 7 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Synergistic effect of basic residues at positions 14-15 of nociceptin on binding affinity and receptor activation

Okada, K., Isozaki, K., Li, J., Matsushima, A., Nose, T., Costa, T. & Shimohigashi, Y., Oct 15 2008, In : Bioorganic and Medicinal Chemistry. 16, 20, p. 9261-9267 7 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)
2007

Double-labelled in situ hybridization reveals the lack of co-localization of mRNAs for the circadian neuropeptide PDF and FMRFamide in brains of the flies Musca domestica and Drosophila melanogaster

Matsushima, A., Takano, K., Yoshida, T., Takeda, Y., Yokotani, S., Shimohigashi, Y. & Shimohigashi, M., Jun 1 2007, In : Journal of biochemistry. 141, 6, p. 867-877 11 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)
29 Citations (Scopus)

Structural evidence for endocrine disruptor bisphenol A binding to human nuclear receptor ERRγ

Matsushima, A., Kakuta, Y., Teramoto, T., Koshiba, T., Liu, X., Okada, H., Tokunaga, T., Kawabata, S. I., Kimura, M. & Shimohigashi, Y., Oct 1 2007, In : Journal of biochemistry. 142, 4, p. 517-524 8 p.

Research output: Contribution to journalArticle

154 Citations (Scopus)
2006

Endocrine disruptor bisphenol A strongly binds to human estrogen-related receptor γ (ERRγ) with high constitutive activity

Takayanagi, S., Tokunaga, T., Liu, X., Okada, H., Matsushima, A. & Shimohigashi, Y., Dec 1 2006, In : Toxicology Letters. 167, 2, p. 95-105 11 p.

Research output: Contribution to journalArticle

249 Citations (Scopus)

Structural isoforms of the circadian neuropeptide PDF expressed in the optic lobes of the cricket Gryllus bimaculatus: Immunocytochemical evidence from specific monoclonal antibodies

Honda, T., Matsushima, A., Sumida, K., Chuman, Y., Sakaguchi, K., Onoue, H., Meinertzhagen, I. A., Shimohigashi, Y. & Shimohigashi, M., Nov 20 2006, In : Journal of Comparative Neurology. 499, 3, p. 404-421 18 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)
2004

cDNA cloning of the housefly pigment-dispersing factor (PDF) precursor protein and its peptides comparison among the insect circadian neuropeptides

Matsushima, A., Sato, S., Chuman, Y., Takeda, Y., Yokotani, S., Nose, T., Tominaga, Y., Shimohigashi, M. & Shimohigashi, Y., Feb 1 2004, In : Journal of Peptide Science. 10, 2, p. 82-91 10 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Structural analysis and identification of novel isoforms of the circadian clock gene period in the silk moth Bombyx mori

Takeda, Y., Chuman, Y., Shirasu, N., Sato, S., Matsushima, A., Kaneki, A., Tominaga, Y., Shimohigashi, Y. & Shimohigashi, M., Sep 1 2004, In : Zoological science. 21, 9, p. 903-915 13 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)
2003

Molecular cloning and circadian expression profile of insect neuropeptide PDF in black blowfly, Phormia regina

Matsushima, A., Yokotani, S., Lui, X., Sumida, K., Honda, T., Sato, S., Kaneki, A., Takeda, Y., Chuman, Y., Ozaki, M., Asai, D., Nose, T., Onoue, H., Ito, Y., Tominaga, Y., Shimohigashi, Y. & Shimohigashi, M., Nov 1 2003, In : Letters in Peptide Science. 10, 5-6, p. 419-430 12 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)
2002

A circadian neuropeptide, pigment-dispersing factor-PDF, in the last-summer cicada Meimuna opalifera: cDNA cloning and immunocytochemistry

Sato, S., Chuman, Y., Matsushima, A., Tominaga, Y., Shimohigashi, Y. & Shimohigashi, M., Aug 1 2002, In : Zoological science. 19, 8, p. 821-828 8 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)

cDNA cloning and nuclear localization of the circadian neuropeptide designated as pigment-dispersing factor PDF in the cricket Gryllus bimaculatus

Chuman, Y., Matsushima, A., Sato, S., Tomioka, K., Tominaga, Y., Meinertzhagen, I. A., Shimohigashi, Y. & Shimohigashi, M., Jan 1 2002, In : Journal of Biochemistry. 131, 6, p. 895-903 9 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)
2000

Edge-to-face CH/π interaction between ligand Phe-phenyl and receptor aromatic group in the thrombin receptor activation

Matsushima, A., Fujita, T., Nose, T. & Shimohigashi, Y., Jan 1 2000, In : Journal of biochemistry. 128, 2, p. 225-232 8 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Exploration of the role of phenylalanine in the thrombin receptor tethered-ligand peptide by substitution with a series of trifluorophenylalanines

Matsushima, A., Fujita, T., Okada, K., Shirasu, N., Nose, T. & Shimohigashi, Y., Nov 1 2000, In : Bulletin of the Chemical Society of Japan. 73, 11, p. 2531-2538 8 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Synthesis of a complete set of L-difluorophenylalanines, L-(F2)Phe, as molecular explorers for the CH/π interaction between peptide ligand and receptor

Fujita, T., Nose, T., Matsushima, A., Okada, K., Asai, D., Yamauchi, Y., Shirasu, N., Honda, T., Shigehiro, D. & Shimohigashi, Y., Feb 5 2000, In : Tetrahedron Letters. 41, 6, p. 923-927 5 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)