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Research Output 2010 2019

  • 714 Citations
  • 11 h-Index
  • 20 Article
  • 1 Comment/debate
  • 1 Review article
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Article
2019
1 Citation (Scopus)

Mouse model of ocular hypertension with retinal ganglion cell degeneration

Mukai, R., Park, D. H., Okunuki, Y., Hasegawa, E., Klokman, G., Kim, C. B., Krishnan, A., Gregory-Ksander, M., Husain, D., Miller, J. W. & Connor, K. M., Jan 2019, In : PloS one. 14, 1, e0208713.

Research output: Contribution to journalArticle

Ocular Hypertension
Retinal Ganglion Cells
Intraocular Pressure
hypertension
eyes
Open Access
Scleral Buckling
Retinal Perforations
photography
optics
Buckling

RIP1 kinase mediates angiogenesis by modulating macrophages in experimental neovascularization

Ueta, T., Ishihara, K., Notomi, S., Lee, J. J., Maidana, D. E., Efstathiou, N. E., Murakami, Y., Hasegawa, E., Azuma, K., Toyono, T., Paschalis, E. I., Aihara, M., Miller, J. W. & Vavvas, D. G., Jan 1 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 47, p. 23705-23713 9 p.

Research output: Contribution to journalArticle

Open Access
Receptor-Interacting Protein Serine-Threonine Kinases
Protein Kinases
Macrophages
Pathologic Neovascularization
Caspases
Cytological Techniques
Vitrectomy
Lymphoma
Cataract
Lymphocytes
2018
3 Citations (Scopus)

Crucial role of P2X7 receptor for effector T cell activation in experimental autoimmune uveitis

Takeda, A., Yamada, H., Hasegawa, E., Arima, M., Notomi, S., Myojin, S., Yoshimura, T., Hisatomi, T., Enaida, H., Yanai, R., Kimura, K., Ishibashi, T. & Sonoda, K. H., May 1 2018, In : Japanese Journal of Ophthalmology. 62, 3, p. 398-406 9 p.

Research output: Contribution to journalArticle

Purinergic P2X7 Receptors
Uveitis
T-Lymphocytes
Interleukin-17
Interferons
1 Citation (Scopus)

Interleukin-6 plays a crucial role in the development of subretinal fibrosis in a mouse model

Sato, K., Takeda, A., Hasegawa, E., Jo, Y. J., Arima, M., Oshima, Y., Ryoji, Y., Nakazawa, T., Yuzawa, M., Nakashizuka, H., Shimada, H., Kimura, K., Ishibashi, T. & Sonoda, K. H., Jan 2 2018, In : Immunological Medicine. 41, 1, p. 23-29 7 p.

Research output: Contribution to journalArticle

Interleukin-6
Fibrosis
Macular Degeneration
Small Interfering RNA
Peritoneal Fibrosis
2017
11 Citations (Scopus)

Cytochrome P450 monooxygenase lipid metabolites are significant second messengers in the resolution of choroidal neovascularization

Hasegawa, E., Inafuku, S., Mulki, L., Okunuki, Y., Yanai, R., Smith, K. E., Kim, C. B., Klokman, G., Bielenberg, D. R., Puli, N., Falck, J. R., Husain, D., Miller, J. W., Edin, M. L., Zeldin, D. C., Lee, K. S. S., Hammock, B. D., Schunck, W. H. & Connor, K. M., Sep 5 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 36, p. E7545-E7553

Research output: Contribution to journalArticle

Choroidal Neovascularization
Second Messenger Systems
Mixed Function Oxygenases
Cytochrome P-450 Enzyme System
Lipids
2015
10 Citations (Scopus)

Galectin-8 ameliorates murine autoimmune ocular pathology and promotes a regulatory T cell response

Sampson, J. F., Hasegawa, E., Mulki, L., Suryawanshi, A., Jiang, S., Chen, W. S., Rabinovich, G. A., Connor, K. M. & Panjwani, N., Jun 30 2015, In : PloS one. 10, 6, e0130772.

Research output: Contribution to journalArticle

Galectins
T-cells
Pathology
Regulatory T-Lymphocytes
T-lymphocytes
18 Citations (Scopus)

Inhibition of the alternative complement pathway preserves photoreceptors after retinal injury

Sweigard, J. H., Matsumoto, H., Smith, K. E., Kim, L. A., Paschalis, E. I., Okonuki, Y., Castillejos, A., Kataoka, K., Hasegawa, E., Yanai, R., Husain, D., Lambris, J. D., Vavvas, D., Miller, J. W. & Connor, K. M., Jul 22 2015, In : Science Translational Medicine. 7, 297, 297ra116.

Research output: Contribution to journalArticle

Alternative Complement Pathway
Photoreceptor Cells
Vertebrate Photoreceptor Cells
Retinal Detachment
Cell Death
2014
16 Citations (Scopus)

Characterization of a spontaneous retinal neovascular mouse model

Hasegawa, E., Sweigard, H., Husain, D., Olivares, A. M., Chang, B., Smith, K. E., Birsner, A. E., D'Amato, R. J., Michaud, N. A., Han, Y., Vavvas, D. G., Miller, J. W., Haider, N. B. & Connor, K. M., Sep 4 2014, In : PloS one. 9, 9, e106507.

Research output: Contribution to journalArticle

Retinal Pigments
angiogenesis
Angiography
retina
animal models
39 Citations (Scopus)

Cytochrome P450-generated metabolites derived from ω-3 fatty acids attenuate neovascularization

Yanai, R., Mulki, L., Hasegawa, E., Takeuchi, K., Sweigard, H., Suzuki, J., Gaissert, P., Vavvas, D. G., Sonoda, K. H., Rothe, M., Schunck, W. H., Miller, J. W. & Connor, K. M., Jul 1 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 26, p. 9603-9608 6 p.

Research output: Contribution to journalArticle

Unsaturated Fatty Acids
Cytochrome P-450 Enzyme System
Fatty Acids
Macular Degeneration
Eicosanoids
5 Citations (Scopus)

EBI3 is pivotal for the initiation of experimental autoimmune uveitis

Takeda, A., Hasegawa, E., Fukuhara, T., Hirakawa, S., Yamada, H., Yang, Y., Yoshimura, T., Hisatomi, T., Oshima, Y., Yoshida, H., Sonoda, K. H. & Ishibashi, T., Aug 2014, In : Experimental Eye Research. 125, p. 107-113 7 p.

Research output: Contribution to journalArticle

Uveitis
Human Herpesvirus 4
Genes
Th1 Cells
Interleukin-27
2013
48 Citations (Scopus)

IL-23-independent induction of IL-17 from γδT cells and innate lymphoid cells promotes experimental intraocular neovascularization

Hasegawa, E., Sonoda, K. H., Shichita, T., Morita, R., Sekiya, T., Kimura, A., Oshima, Y., Takeda, A., Yoshimura, T., Yoshida, S., Ishibashi, T. & Yoshimura, A., Feb 15 2013, In : Journal of Immunology. 190, 4, p. 1778-1787 10 p.

Research output: Contribution to journalArticle

Interleukin-23
Interleukin-17
Choroidal Neovascularization
Lymphocytes
T-Lymphocytes
2012
6 Citations (Scopus)

Forced expression of stabilized c-Fos in dendritic cells reduces cytokine production and immune responses in vivo

Yoshida, R., Suzuki, M., Sakaguchi, R., Hasegawa, E., Kimura, A., Shichita, T., Sekiya, T., Shiraishi, H., Shimoda, K. & Yoshimura, A., Jun 29 2012, In : Biochemical and Biophysical Research Communications. 423, 2, p. 247-252 6 p.

Research output: Contribution to journalArticle

Dendritic Cells
Cytokines
Proto-Oncogene Proteins c-fos
Phosphorylation
T-cells
16 Citations (Scopus)

IL-27 inhibits pathophysiological intraocular neovascularization due to laser burn

Hasegawa, E., Oshima, Y., Takeda, A., Saeki, K., Yoshida, H., Sonoda, K. H. & Ishibashi, T., Feb 1 2012, In : Journal of Leukocyte Biology. 91, 2, p. 267-273 7 p.

Research output: Contribution to journalArticle

Interleukin-27
Lasers
Vascular Endothelial Growth Factor A
Choroid
Blindness
229 Citations (Scopus)

Peroxiredoxin family proteins are key initiators of post-ischemic inflammation in the brain

Shichita, T., Hasegawa, E., Kimura, A., Morita, R., Sakaguchi, R., Takada, I., Sekiya, T., Ooboshi, H., Kitazono, T., Yanagawa, T., Ishii, T., Takahashi, H., Mori, S., Nishibori, M., Kuroda, K., Akira, S., Miyake, K. & Yoshimura, A., Jun 1 2012, In : Nature medicine. 18, 6, p. 911-917 7 p.

Research output: Contribution to journalArticle

Peroxiredoxins
Encephalitis
Macrophages
Brain
Macrophage Activation
2011
42 Citations (Scopus)

Suppression of SOCS3 in macrophages prevents cancer metastasis by modifying macrophage phase and MCP2/CCL8 induction

Hiwatashi, K., Tamiya, T., Hasegawa, E., Fukaya, T., Hashimoto, M., Kakoi, K., Kashiwagi, I., Kimura, A., Inoue, N., Morita, R., Yasukawa, H. & Yoshimura, A., Sep 28 2011, In : Cancer Letters. 308, 2, p. 172-180 9 p.

Research output: Contribution to journalArticle

Macrophages
Cytokines
Neoplasm Metastasis
Neoplasms
Knockout Mice
2010
38 Citations (Scopus)

Choroidal neovascularization enhanced by chlamydia pneumoniae via toll-like receptor 2 in the retinal pigment epithelium

Fujimoto, T., Sonoda, K. H., Hijioka, K., Sato, K., Takeda, A., Hasegawa, E., Oshima, Y. & Ishibashi, T., Sep 1 2010, In : Investigative Ophthalmology and Visual Science. 51, 9, p. 4694-4702 9 p.

Research output: Contribution to journalArticle

Toll-Like Receptor 2
Chlamydophila pneumoniae
Choroidal Neovascularization
Retinal Pigment Epithelium
Knockout Mice
181 Citations (Scopus)

Smad2 and Smad3 are redundantly essential for the TGF-β-mediated regulation of regulatory T plasticity and Th1 development

Takimoto, T., Wakabayashi, Y., Sekiya, T., Inoue, N., Morita, R., Ichiyama, K., Takahashi, R., Asakawa, M., Muto, G., Mori, T., Hasegawa, E., Shizuya, S., Hara, T., Nomura, M. & Yoshimura, A., Jul 15 2010, In : Journal of Immunology. 185, 2, p. 842-855 14 p.

Research output: Contribution to journalArticle

T-Lymphocytes
Knockout Mice
Th17 Cells
Th1 Cells
Regulatory T-Lymphocytes
50 Citations (Scopus)

Therapeutic effect of IL-12/23 and their signaling pathway blockade on brain ischemia model

Konoeda, F., Shichita, T., Yoshida, H., Sugiyama, Y., Muto, G., Hasegawa, E., Morita, R., Suzuki, N. & Yoshimura, A., Nov 19 2010, In : Biochemical and Biophysical Research Communications. 402, 3, p. 500-506 7 p.

Research output: Contribution to journalArticle

Brain models
Interleukin-23
Interleukin-17
Therapeutic Uses
Interleukin-12