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Eiji Iwama

Assistant Professor

  • 858 Citations
  • 12 h-Index
20112019
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Research Output 2011 2019

  • 858 Citations
  • 12 h-Index
  • 38 Article
  • 4 Review article
  • 1 Letter
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Article
Article

A case of smoking-related interstitial lung disease with a histopathologic pattern overlapping that of usual interstitial pneumonia and respiratory bronchiolitis

Sawada, Y., Kitasato, Y., Watanabe, K., Okamoto, M., Iwama, E., Yoshimi, M., Okabayashi, K., Tarata, S., Kawayama, T. & Hoshino, T., Jan 1 2014, In : Japanese Journal of Chest Diseases. 73, 5, p. 580-586 7 p.

Research output: Contribution to journal › Article

Idiopathic Pulmonary Fibrosis
Bronchiolitis
Interstitial Lung Diseases
Smoking
Lung
32 Citations (Scopus)

Addition of bevacizumab enhances antitumor activity of erlotinib against non-small cell lung cancer xenografts depending on VEGF expression

Li, H., Takayama, K., Wang, S., Shiraishi, Y., Gotanda, K., Harada, T., Furuyama, K., Iwama, E., Ieiri, I., Okamoto, I. & Nakanishi, Y., Oct 9 2014, In : Cancer chemotherapy and pharmacology. 74, 6, p. 1297-1305 9 p.

Research output: Contribution to journal › Article

Heterografts
Non-Small Cell Lung Carcinoma
Vascular Endothelial Growth Factor A
Cells
Tumors
13 Citations (Scopus)

Alectinib for Patients with ALK Rearrangement–Positive Non–Small Cell Lung Cancer and a Poor Performance Status (Lung Oncology Group in Kyushu 1401)

Iwama, E., Goto, Y., Murakami, H., Harada, T., Tsumura, S., Sakashita, H., Mori, Y., Nakagaki, N., Fujita, Y., Seike, M., Bessho, A., Ono, M., Okazaki, A., Akamatsu, H., Morinaga, R., Ushijima, S., Shimose, T., Tokunaga, S., Hamada, A., Yamamoto, N. & 3 others, Nakanishi, Y., Sugio, K. & Okamoto, I., Jul 1 2017, In : Journal of Thoracic Oncology. 12, 7, p. 1161-1166 6 p.

Research output: Contribution to journal › Article

Non-Small Cell Lung Carcinoma
Lung
Confidence Intervals
Patient Safety
CH5424802

Association of nephrotoxicity during platinum-etoposide doublet therapy with UGT1A1 polymorphisms in small cell lung cancer patients

Anai, S., Iwama, E., Yoneshima, Y., Otsubo, K., Tanaka, K., Nakanishi, Y. & Okamoto, I., Dec 1 2018, In : Lung Cancer. 126, p. 156-161 6 p.

Research output: Contribution to journal › Article

Small Cell Lung Carcinoma
Etoposide
Platinum
Alleles
irinotecan
318 Citations (Scopus)

Association of PD-L1 overexpression with activating EGFR mutations in surgically resected nonsmall-cell lung cancer

Azuma, K., Ota, K., Kawahara, A., Hattori, S., Iwama, E., Harada, T., Matsumoto, K., Takayama, K., Takamori, S., Kage, M., Hoshino, T., Nakanishi, Y. & Okamoto, I., Oct 1 2014, In : Annals of oncology : official journal of the European Society for Medical Oncology / ESMO. 25, 10, p. 1935-1940 6 p.

Research output: Contribution to journal › Article

erbB-1 Genes
Non-Small Cell Lung Carcinoma
Ligands
Mutation
Cell Line
12 Citations (Scopus)

Cancer-related PRUNE2 protein is associated with nucleotides and is highly expressed in mature nerve tissues

Iwama, E., Tsuchimoto, D., Iyama, T., Kunihiko, S., Nakagawara, A., Takayama, K., Nakanishi, Y. & Nakabeppu, Y., Jun 1 2011, In : Journal of Molecular Neuroscience. 44, 2, p. 103-114 12 p.

Research output: Contribution to journal › Article

Nerve Tissue
Guanosine Triphosphate
Nucleotides
Spinal Ganglia
Neoplasms
4 Citations (Scopus)

CD44 variant–dependent regulation of redox balance in EGFR mutation–positive non–small cell lung cancer: A target for treatment

Kawano, Y., Iwama, E., Tsuchihashi, K., Shibahara, D., Harada, T., Tanaka, K., Nagano, O., Saya, H., Nakanishi, Y. & Okamoto, I., Nov 1 2017, In : Lung Cancer. 113, p. 72-78 7 p.

Research output: Contribution to journal › Article

erbB-1 Genes
Non-Small Cell Lung Carcinoma
Oxidation-Reduction
Reactive Oxygen Species
Cisplatin
5 Citations (Scopus)

Characteristics of smoking patients with lung cancer with emphysematous bullae

Iwama, E., Okamoto, I., Yabuuchi, H., Takayama, K., Harada, T., Matsuo, Y., Tokunaga, S., Baba, E. & Nakanishi, Y., Jan 1 2016, In : Journal of Thoracic Oncology. 11, 9, p. 1586-1590 5 p.

Research output: Contribution to journal › Article

Blister
Lung Neoplasms
Smoking
Emphysema
Epidermal Growth Factor
1 Citation (Scopus)

Chronic myelomonocytic leukemia blast crisis in a patient with advanced non-small cell lung cancer treated with EGFR tyrosine kinase inhibitors

Ogata, H., Okamoto, I., Yoshimoto, G., Obara, T., Ijichi, K., Iwama, E., Harada, T., Akashi, K. & Nakanishi, Y., Mar 1 2017, In : Respiratory Investigation. 55, 2, p. 181-183 3 p.

Research output: Contribution to journal › Article

Leukemia, Myelomonocytic, Chronic
erbB-1 Genes
Blast Crisis
Non-Small Cell Lung Carcinoma
Protein-Tyrosine Kinases
3 Citations (Scopus)

Detection of identical T cell clones in peritumoral pleural effusion and pneumonitis lesions in a cancer patient during immune-checkpoint blockade

Tanaka, K., Yanagihara, T., Ikematsu, Y., Inoue, H., Ota, K., Kashiwagi, E., Suzuki, K., Hamada, N., Takeuchi, A., Tatsugami, K., Eto, M., Ijichi, K., Oda, Y., Otsubo, K., Yoneshima, Y., Iwama, E., Nakanishi, Y. & Okamoto, I., Jul 17 2018, In : Oncotarget. 9, 55, p. 30587-30593 7 p.

Research output: Contribution to journal › Article

Bronchoalveolar Lavage Fluid
Pleural Effusion
Pneumonia
Clone Cells
T-Cell Antigen Receptor
8 Citations (Scopus)

Exploration of resistance mechanisms for epidermal growth factor receptor-tyrosine kinase inhibitors based on plasma analysis by digital polymerase chain reaction and next-generation sequencing

Iwama, E., Sakai, K., Azuma, K., Harada, D., Nosaki, K., Hotta, K., Nishio, M., Kurata, T., Fukuhara, T., Akamatsu, H., Goto, K., Shimose, T., Kishimoto, J., Nakanishi, Y., Nishio, K. & Okamoto, I., Dec 2018, In : Cancer Science. 109, 12, p. 3921-3933 13 p.

Research output: Contribution to journal › Article

Epidermal Growth Factor Receptor
Protein-Tyrosine Kinases
Polymerase Chain Reaction
Mutation
Neoplasms
2 Citations (Scopus)

Expression of brain-derived neurotrophic factor and its receptor TrkB is associated with poor prognosis and a malignant phenotype in small cell lung cancer

Kimura, S., Harada, T., Ijichi, K., Tanaka, K., Liu, R., Shibahara, D., Kawano, Y., Otsubo, K., Yoneshima, Y., Iwama, E., Nakanishi, Y. & Okamoto, I., Jun 1 2018, In : Lung Cancer. 120, p. 98-107 10 p.

Research output: Contribution to journal › Article

trkB Receptor
Brain-Derived Neurotrophic Factor
Small Cell Lung Carcinoma
Phenotype
Non-Small Cell Lung Carcinoma

Genetic Profiling of Non-Small Cell Lung Cancer at Development of Resistance to First- or Second-Generation EGFR-TKIs by CAPP-Seq Analysis of Circulating Tumor DNA

Otsubo, K., Sakai, K., Takeshita, M., Harada, D., Azuma, K., ota, K., Akamatsu, H., Goto, K., Horiike, A., Kurata, T., Nakagaki, N., Nosaki, K., Iwama, E., Nakanishi, Y., Nishio, K. & Okamoto, I., Jan 1 2019, In : Oncologist. 24, 8, p. 1022-1026 5 p.

Research output: Contribution to journal › Article

High-Throughput Nucleotide Sequencing
Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
Protein-Tyrosine Kinases
DNA
19 Citations (Scopus)

Highly sensitive and quantitative evaluation of the EGFR T790M mutation by nanofluidic digital PCR

Iwama, E., Takayama, K., Harada, T., Okamoto, I., Ookubo, F., Kishimoto, J., Baba, E., Oda, Y. & Nakanishi, Y., Jan 1 2015, In : Oncotarget. 6, 24, p. 20466-20473 8 p.

Research output: Contribution to journal › Article

Polymerase Chain Reaction
Mutation
Alleles
Therapeutics
Neoplasms
9 Citations (Scopus)

Hypermethylation of the CpG dinucleotide in epidermal growth factor receptor codon 790: Implications for a mutational hotspot leading to the T790M mutation in non-small-cell lung cancer

Fujii, A., Harada, T., Iwama, E., ota, K., Furuyama, K., Ijichi, K., Okamoto, T., Okamoto, I., Takayama, K. & Nakanishi, Y., May 1 2015, In : Cancer Genetics. 208, 5, p. 271-278 8 p.

Research output: Contribution to journal › Article

5-Methylcytosine
Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
Codon
Mutation

Identification of genomic alterations acquired during treatment with EGFR-TKIs in non-small cell lung cancer

Kubo, N., Harada, T., Shiraishi, Y., Nosaki, K., Nakagaki, N., Takeshita, M., Ouchi, H., Iwama, E., Tanaka, K., Okamoto, I., Sasaki, H. & Nakanishi, Y., Feb 1 2019, In : Anticancer research. 39, 2, p. 671-677 7 p.

Research output: Contribution to journal › Article

Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
Protein-Tyrosine Kinases
Therapeutics
Exome

II. Development and future prospects of the third-generation EGFR-tyrosine kinase inhibitor

Sakata, S., Iwama, E. & Okamoto, I., Aug 1 2015, In : Japanese Journal of Cancer and Chemotherapy. 42, 8, p. 935-939 5 p.

Research output: Contribution to journal › Article

Protein-Tyrosine Kinases

II. Development and Future Prospects of the Third-Generation EGFR-Tyrosine Kinase Inhibitor

Sakata, S., Iwama, E. & Okamoto, I., Aug 1 2015, In : Japanese Journal of Cancer and Chemotherapy. 42, 8, p. 935-939 5 p.

Research output: Contribution to journal › Article

Drug Design
Protein Kinase Inhibitors
Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
Protein-Tyrosine Kinases

Immune checkpoint protein and cytokine expression by T lymphocytes in pleural effusion of cancer patients receiving anti–PD-1 therapy

Ikematsu, Y., Tanaka, K., Yanagihara, T., Liu, R., Inoue, H., Yoneshima, Y., Ota, K., Iwama, E., Takata, S., Hata, K., Takahata, Y., Wataya, H., Nakanishi, Y. & Okamoto, I., Dec 2019, In : Lung Cancer. 138, p. 58-64 7 p.

Research output: Contribution to journal › Article

Pleural Effusion
Cytokines
T-Lymphocytes
Cell- and Tissue-Based Therapy
Neoplasms
220 Citations (Scopus)

Induction of PD-L1 expression by the EML4-ALK oncoprotein and down stream signaling pathways in non-small cell lung cancer

ota, K., Azuma, K., Kawahara, A., Hattori, S., Iwama, E., Tanizaki, J., Harada, T., Matsumoto, K., Takayama, K., Takamori, S., Kage, M., Hoshino, T., Nakanishi, Y. & Okamoto, I., Sep 1 2015, In : Clinical Cancer Research. 21, 17, p. 4014-4021 8 p.

Research output: Contribution to journal › Article

Oncogene Proteins
Non-Small Cell Lung Carcinoma
Gene Fusion
Phosphatidylinositol 3-Kinases
Cell Line
4 Citations (Scopus)

Infected complex renal cysts during crizotinib therapy in a patient with non-small cell lung cancer positive for ALK rearrangement

Yoneshima, Y., Okamoto, I., Arimura-Omori, M., Kimura, S., Hidaka-Fujimoto, N., Iwama, E., Harada, T., Takayama, K. & Nakanishi, Y., Apr 1 2015, In : Investigational New Drugs. 33, 2, p. 510-512 3 p.

Research output: Contribution to journal › Article

Non-Small Cell Lung Carcinoma
Cysts
Kidney
Therapeutics
Low Back Pain
5 Citations (Scopus)

Intrinsic and Extrinsic Regulation of PD-L2 Expression in Oncogene-Driven Non–Small Cell Lung Cancer

Shibahara, D., Tanaka, K., Iwama, E., Kubo, N., Ota, K., Azuma, K., Harada, T., Fujita, J., Nakanishi, Y. & Okamoto, I., Jul 2018, In : Journal of Thoracic Oncology. 13, 7, p. 926-937 12 p.

Research output: Contribution to journal › Article

Oncogenes
Non-Small Cell Lung Carcinoma
Cell Death
Ligands
STAT3 Transcription Factor
1 Citation (Scopus)

Longitudinal monitoring of somatic genetic alterations in circulating cell-free DNA during treatment with epidermal growth factor receptor–tyrosine kinase inhibitors

Iwama, E., Sakai, K., Hidaka, N., Inoue, K., Fujii, A., Nakagaki, N., Ota, K., Toyozawa, R., Azuma, K., Nakatomi, K., Harada, T., Hisasue, J., Sakata, S., Shimose, T., Kishimoto, J., Nakanishi, Y., Nishio, K. & Okamoto, I., Jan 1 2019, (Accepted/In press) In : Cancer.

Research output: Contribution to journal › Article

Epidermal Growth Factor Receptor
Epidermal Growth Factor
Phosphotransferases
DNA
Protein-Tyrosine Kinases
23 Citations (Scopus)

Monitoring of somatic mutations in circulating cell-free DNA by digital PCR and next-generation sequencing during afatinib treatment in patients with lung adenocarcinoma positive for EGFR activating mutations

Iwama, E., Sakai, K., Azuma, K., Harada, T., Harada, D., Nosaki, K., Hotta, K., Ohyanagi, F., Kurata, T., Fukuhara, T., Akamatsu, H., Goto, K., Shimose, T., Kishimoto, J., Nakanishi, Y., Nishio, K. & Okamoto, I., Jan 1 2017, In : Annals of Oncology. 28, 1, p. 136-141 6 p.

Research output: Contribution to journal › Article

Epidermal Growth Factor Receptor
Polymerase Chain Reaction
Mutation
DNA
Alleles
17 Citations (Scopus)

Most T790M mutations are present on the same EGFR allele as activating mutations in patients with non–small cell lung cancer

Hidaka, N., Iwama, E., Kubo, N., Harada, T., Miyawaki, K., Tanaka, K., Okamoto, I., Baba, E., Akashi, K., Sasaki, H. & Nakanishi, Y., Jun 1 2017, In : Lung Cancer. 108, p. 75-82 8 p.

Research output: Contribution to journal › Article

erbB-1 Genes
Non-Small Cell Lung Carcinoma
Alleles
Mutation
Protein-Tyrosine Kinases
18 Citations (Scopus)

Nicotine induces resistance to erlotinib via cross-talk between α 1 nAChR and EGFR in the non-small cell lung cancer xenograft model

Li, H., Wang, S., Takayama, K., Harada, T., Okamoto, I., Iwama, E., Fujii, A., ota, K., Hidaka, N., Kawano, Y. & Nakanishi, Y., Apr 1 2015, In : Lung Cancer. 88, 1, p. 1-8 8 p.

Research output: Contribution to journal › Article

Nicotinic Receptors
Nicotine
Heterografts
Non-Small Cell Lung Carcinoma
MAP Kinase Signaling System
15 Citations (Scopus)

PD-L1 expression in lung adenocarcinoma harboring EGFR mutations or ALK rearrangements

Yoneshima, Y., Ijichi, K., Anai, S., ota, K., Otsubo, K., Iwama, E., Tanaka, K., Oda, Y., Nakanishi, Y. & Okamoto, I., Apr 1 2018, In : Lung Cancer. 118, p. 36-40 5 p.

Research output: Contribution to journal › Article

Mutation
Neoplasms
Adenocarcinoma of lung
Protein-Tyrosine Kinases
Oncogenes
4 Citations (Scopus)

Pemetrexed combined with platinum-based chemotherapy for advanced malignant peritoneal mesothelioma: Retrospective analysis of six cases

Nakano, M., Kusaba, H., Makiyama, A., ariyama, H., Arita, S., Oda, H., Esaki, T., Takayoshi, K., Uchino, K., Tamura, S., Kumagai, H., Iwama, E., Shirakawa, T., Mitsugi, K., Takaishi, S., Akashi, K. & Baba, E., Jan 1 2014, In : Anticancer Research. 34, 1, p. 215-220 6 p.

Research output: Contribution to journal › Article

Pemetrexed
Platinum
Mesothelioma
Ascites
Drug Therapy
14 Citations (Scopus)

Phase II trial of weekly nab-paclitaxel for previously treated advanced non–small cell lung cancer: Kumamoto thoracic oncology study group (KTOSG) trial 1301

Sakata, S., Saeki, S., Okamoto, I., Otsubo, K., Komiya, K., Morinaga, R., Yoneshima, Y., Koga, Y., Enokizu, A., Kishi, H., Hirosako, S., Yamaguchi, E., Aragane, N., Fujii, S., Harada, T., Iwama, E., Semba, H., Nakanishi, Y. & Kohrogi, H., Sep 1 2016, In : Lung Cancer. 99, p. 41-45 5 p.

Research output: Contribution to journal › Article

Non-Small Cell Lung Carcinoma
Thorax
docetaxel
Confidence Intervals
Febrile Neutropenia
8 Citations (Scopus)

Phase I study of salazosulfapyridine in combination with cisplatin and pemetrexed for advanced non-small-cell lung cancer

Otsubo, K., Nosaki, K., Imamura, C. K., Ogata, H., Fujita, A., Sakata, S., Hirai, F., Toyokawa, G., Iwama, E., Harada, T., Seto, T., Takenoyama, M., Ozeki, T., Mushiroda, T., Inada, M., Kishimoto, J., Tsuchihashi, K., Suina, K., Nagano, O., Saya, H. & 2 others, Nakanishi, Y. & Okamoto, I., Sep 2017, In : Cancer Science. 108, 9, p. 1843-1849 7 p.

Research output: Contribution to journal › Article

Pemetrexed
Sulfasalazine
Non-Small Cell Lung Carcinoma
Cisplatin
Neoplastic Stem Cells
10 Citations (Scopus)

PICT1 expression is a poor prognostic factor in non-small cell lung cancer

Okamura, K., Takayama, K., Kawahara, K., Harada, T., Nishio, M., Otsubo, K., Ijichi, K., Kohno, M., Iwama, E., Fujii, A., Ota, K., Koga, T., Okamoto, T., Suzuki, A. & Nakanishi, Y., Jan 1 2014, In : Oncoscience. 1, 5, p. 375-382 8 p.

Research output: Contribution to journal › Article

Non-Small Cell Lung Carcinoma
Neoplasms
Cytoplasm
Multivariate Analysis
Smoking
1 Citation (Scopus)

Prediction of therapeutic effect of chemotherapy for NSCLC using dual-input perfusion CT analysis: Comparison among bevacizumab treatment, two- agent platinum-based therapy without bevacizumab, and other non- bevacizumab treatment groups

Yabuuchi, H., Kawanami, S., Iwama, E., Okamoto, I., Kamitani, T., Sagiyama, K., Yamasaki, Y. & Honda, H., Feb 1 2018, In : Radiology. 286, 2, p. 685-695 11 p.

Research output: Contribution to journal › Article

Therapeutic Uses
Platinum
Non-Small Cell Lung Carcinoma
Perfusion
Tomography
11 Citations (Scopus)

Risk factors for predicting severe neutropenia induced by pemetrexed plus carboplatin therapy in patients with advanced non-small cell lung cancer

Ikesue, H., Watanabe, H., Hirano, M., Chikamori, A., Suetsugu, K., Ryokai, Y., Egashira, N., Yamada, T., Ikeda, M., Iwama, E., Harada, T., Takayama, K., Nakanishi, Y. & Masuda, S., Aug 1 2015, In : Biological and Pharmaceutical Bulletin. 38, 8, p. 1192-1198 7 p.

Research output: Contribution to journal › Article

Pemetrexed
Carboplatin
Neutropenia
Non-Small Cell Lung Carcinoma
Hemoglobins
2 Citations (Scopus)

Safety and efficacy of PD-1 inhibitors in non–small cell lung cancer patients positive for antinuclear antibodies

Yoneshima, Y., Tanaka, K., Shiraishi, Y., Hata, K., Watanabe, H., Harada, T., Otsubo, K., Iwama, E., Inoue, H., Masuda, S., Nakanishi, Y. & Okamoto, I., Apr 1 2019, In : Lung Cancer. 130, p. 5-9 5 p.

Research output: Contribution to journal › Article

Antinuclear Antibodies
Non-Small Cell Lung Carcinoma
Safety
Autoimmune Diseases
Disease-Free Survival
29 Citations (Scopus)

Sensitivity and kinase activity of epidermal growth factor receptor (EGFR) exon 19 and others to EGFR-tyrosine kinase inhibitors

Furuyama, K., Harada, T., Iwama, E., Shiraishi, Y., Okamura, K., Ijichi, K., Fujii, A., ota, K., Wang, S., Li, H., Takayama, K., Giaccone, G. & Nakanishi, Y., May 1 2013, In : Cancer Science. 104, 5, p. 584-589 6 p.

Research output: Contribution to journal › Article

Epidermal Growth Factor Receptor
Protein-Tyrosine Kinases
Exons
Mutation
Phosphotransferases
10 Citations (Scopus)

Severe acute interstitial lung disease in a patient with anaplastic lymphoma kinase rearrangement-positive non-small cell lung cancer treated with alectinib

Yamamoto, Y., Okamoto, I., Otsubo, K., Iwama, E., Hamada, N., Harada, T., Takayama, K. & Nakanishi, Y., Oct 22 2015, In : Investigational New Drugs. 33, 5, p. 1148-1150 3 p.

Research output: Contribution to journal › Article

Interstitial Lung Diseases
Non-Small Cell Lung Carcinoma
Tomography
Lymphocytosis
Bronchoalveolar Lavage Fluid
6 Citations (Scopus)

Successful treatment with alectinib after crizotinib-induced esophageal ulceration

Yoneshima, Y., Okamoto, I., Takano, T., Enokizu, A., Iwama, E., Harada, T., Takayama, K. & Nakanishi, Y., Jun 1 2015, In : Lung Cancer. 88, 3, p. 349-351 3 p.

Research output: Contribution to journal › Article

Therapeutics
Protein-Tyrosine Kinases
crizotinib
CH5424802
Wounds and Injuries

Survival Analysis for Patients with ALK Rearrangement-Positive Non-Small Cell Lung Cancer and a Poor Performance Status Treated with Alectinib: Updated Results of Lung Oncology Group in Kyushu 1401

Iwama, E., Goto, Y., Murakami, H., Tsumura, S., Sakashita, H., Mori, Y., Nakagaki, N., Fujita, Y., Seike, M., Bessho, A., Ono, M., Nishitsuji, M., Akamatsu, H., Morinaga, R., Akagi, T., Shimose, T., Tokunaga, S., Yamamoto, N., Nakanishi, Y., Sugio, K. & 1 others, Okamoto, I., Jan 1 2019, (Accepted/In press) In : Oncologist.

Research output: Contribution to journal › Article

Open Access
Survival Analysis
Non-Small Cell Lung Carcinoma
Lung
Survival
Central Nervous System