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Fingerprint Dive into the research topics where Eiji Kawanishi is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

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Sodium-Glucose Transport Proteins Medicine & Life Sciences
Glucosides Chemical Compounds
Thiophenes Medicine & Life Sciences
Epoxy Compounds Chemical Compounds
Alkylation Chemical Compounds
Sodium Chemical Compounds
Glucose Chemical Compounds
Phosphoric Diester Hydrolases Medicine & Life Sciences

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Research Output 1991 2019

Discovery of a pyrazolo[1,5-a]pyrimidine derivative (MT-3014) as a highly selective PDE10A inhibitor via core structure transformation from the stilbene moiety

Koizumi, Y., Tanaka, Y., Matsumura, T., Kadoh, Y., Miyoshi, H., Hongu, M., Takedomi, K., Kotera, J., Sasaki, T., Taniguchi, H., Watanabe, Y., Takakuwa, M., Kojima, K., Baba, N., Nakamura, I. & Kawanishi, E., Aug 1 2019, In : Bioorganic and Medicinal Chemistry. 27, 15, p. 3440-3450 11 p.

Research output: Contribution to journalArticle

Stilbenes
Rats
Lead compounds
Derivatives
Pharmacokinetics

Scalable Process Design for a PDE10A Inhibitor Consisting of Pyrazolopyrimidine and Quinoxaline as Key Units

Yamagami, T., Kobayashi, R., Moriyama, N., Horiuchi, H., Toyofuku, E., Kadoh, Y., Kawanishi, E., Izumoto, S., Hiramatsu, H., Nanjo, T., Sugino, M., Utsugi, M. & Moritani, Y., Apr 19 2019, In : Organic Process Research and Development. 23, 4, p. 578-587 10 p.

Research output: Contribution to journalArticle

quinoxalines
Quinoxalines
pyrimidines
inhibitors
Process design

Discovery of 2-[(E)-2-(7-fluoro-3-methylquinoxalin-2-yl)vinyl]-6-pyrrolidin- 1-yl-N-(tetrahydro-2H-pyran-4-yl)pyrimidin-4-amine hydrochloride as a highly selective PDE10A inhibitor

Kadoh, Y., Miyoshi, H., Matsumura, T., Tanaka, Y., Hongu, M., Kimura, M., Takedomi, K., Omori, K., Kotera, J., Sasaki, T., Kobayashi, T., Taniguchi, H., Watanabe, Y., Kojima, K., Sakamoto, T., Himiyama, T. & Kawanishi, E., Jan 1 2018, In : Chemical and Pharmaceutical Bulletin. 66, 3, p. 243-250 8 p.

Research output: Contribution to journalArticle

Pyrans
Neurons
Amines
Phosphodiesterase 5 Inhibitors
Quinoxalines

Synthetic Method for 2′-Amino-LNA Bearing Any of the Four Nucleobases via a Transglycosylation Reaction

Sawamoto, H., Arai, Y., Yamakoshi, S., Obika, S. & Kawanishi, E., Apr 6 2018, In : Organic Letters. 20, 7, p. 1928-1931 4 p.

Research output: Contribution to journalArticle

Bearings (structural)
5-Methylcytosine
Thymine
Guanine
nucleic acids

Computation-assisted disconnection approach for the synthesis of neoantimycins, 15-membered macrocyclic depsipeptides

Yamakoshi, S., Okamoto, M., Sawamoto, H., Arai, Y., Kawanishi, E., Sasaki, M. & Takeda, K., Mar 1 2017, In : Current Organic Synthesis. 14, 2, p. 299-308 10 p.

Research output: Contribution to journalArticle

Depsipeptides
Cyclization
Carbon
Carbon Monoxide
Mechanics