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Research Output

2019

Cell-based screen identifies a new potent and highly selective CK2 inhibitor for modulation of circadian rhythms and cancer cell growth

Oshima, T., Niwa, Y., Kuwata, K., Srivastava, A., Hyoda, T., Tsuchiya, Y., Kumagai, M., Tsuyuguchi, M., Tamaru, T., Sugiyama, A., Ono, N., Zolboot, N., Aikawa, Y., Oishi, S., Nonami, A., Arai, F., Hagihara, S., Yamaguchi, J., Tama, F., Kunisaki, Y. & 6 others, Yagita, K., Ikeda, M., Kinoshita, T., Kay, S. A., Itami, K. & Hirota, T., Jan 23 2019, In : Science Advances. 5, 1, eaau9060.

Research output: Contribution to journalArticle

Open Access
23 Citations (Scopus)

Environmental Optimization Enables Maintenance of Quiescent Hematopoietic Stem Cells Ex Vivo

Kobayashi, H., Morikawa, T., Okinaga, A., Hamano, F., Hashidate-Yoshida, T., Watanuki, S., Hishikawa, D., Shindou, H., Arai, F., Kabe, Y., Suematsu, M., Shimizu, T. & Takubo, K., Jul 2 2019, In : Cell Reports. 28, 1, p. 145-158.e9

Research output: Contribution to journalArticle

Open Access
8 Citations (Scopus)

Regnase-1-mediated post-transcriptional regulation is essential for hematopoietic stem and progenitor cell homeostasis

Kidoya, H., Muramatsu, F., Shimamura, T., Jia, W., Satoh, T., Hayashi, Y., Naito, H., Kunisaki, Y., Arai, F., Seki, M., Suzuki, Y., Osawa, T., Akira, S. & Takakura, N., Dec 1 2019, In : Nature communications. 10, 1, 1072.

Research output: Contribution to journalArticle

Open Access
4 Citations (Scopus)
2018

Genome-wide CRISPR-Cas9 Screen Identifies Leukemia-Specific Dependence on a Pre-mRNA Metabolic Pathway Regulated by DCPS

Yamauchi, T., Masuda, T., Canver, M. C., Seiler, M., Semba, Y., Shboul, M., Al-Raqad, M., Maeda, M., Schoonenberg, V. A. C., Cole, M. A., Macias-Trevino, C., Ishikawa, Y., Yao, Q., Nakano, M., Arai, F., Orkin, S. H., Reversade, B., Buonamici, S., Pinello, L., Akashi, K. & 2 others, Bauer, D. E. & Maeda, T., Mar 12 2018, In : Cancer Cell. 33, 3, p. 386-400.e5

Research output: Contribution to journalArticle

25 Citations (Scopus)

Guest editorial: Regulatory signaling in normal and abnormal hematopoiesis

Arai, F., Jun 1 2018, In : International journal of hematology. 107, 6, p. 624-626 3 p.

Research output: Contribution to journalEditorial

Spred1 Safeguards Hematopoietic Homeostasis against Diet-Induced Systemic Stress

Tadokoro, Y., Hoshii, T., Yamazaki, S., Eto, K., Ema, H., Kobayashi, M., Ueno, M., Ohta, K., Arai, Y., Hara, E., Harada, K., Oshima, M., Oshima, H., Arai, F., Yoshimura, A., Nakauchi, H. & Hirao, A., May 3 2018, In : Cell stem cell. 22, 5, p. 713-725.e8

Research output: Contribution to journalArticle

9 Citations (Scopus)

The role of telomere binding molecules for normal and abnormal hematopoiesis

Hosokawa, K. & Arai, F., Jun 1 2018, In : International journal of hematology. 107, 6, p. 646-655 10 p.

Research output: Contribution to journalReview article

5 Citations (Scopus)
2017

Functional dissection of hematopoietic stem cell populations with a stemness-monitoring system based on NS-GFP transgene expression

Ali, M. A. E., Fuse, K., Tadokoro, Y., Hoshii, T., Ueno, M., Kobayashi, M., Nomura, N., Vu, H. T., Peng, H., Hegazy, A. M., Masuko, M., Sone, H., Arai, F., Tajima, A. & Hirao, A., Dec 1 2017, In : Scientific reports. 7, 1, 11442.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Stem Cell Differentiation as a Non-Markov Stochastic Process

Stumpf, P. S., Smith, R. C. G., Lenz, M., Schuppert, A., Müller, F. J., Babtie, A., Chan, T. E., Stumpf, M. P. H., Please, C. P., Howison, S. D., Arai, F. & MacArthur, B. D., Sep 27 2017, In : Cell Systems. 5, 3, p. 268-282.e7

Research output: Contribution to journalArticle

35 Citations (Scopus)

The telomere binding protein Pot1 maintains haematopoietic stem cell activity with age

Hosokawa, K., MacArthur, B. D., Ikushima, Y. M., Toyama, H., Masuhiro, Y., Hanazawa, S., Suda, T. & Arai, F., Dec 1 2017, In : Nature communications. 8, 1, 804.

Research output: Contribution to journalArticle

12 Citations (Scopus)
2016

Self-renewal and differentiation of hematopoietic stem cells

Arai, F., Jan 1 2016, In : [Rinsho ketsueki] The Japanese journal of clinical hematology. 57, 10, p. 1845-1851 7 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Self-renewal of a purified Tie2+ hematopoietic stem cell population relies on mitochondrial clearance

Ito, K., Turcotte, R., Cui, J., Zimmerman, S. E., Pinho, S., Mizoguchi, T., Arai, F., Runnels, J. M., Alt, C., Teruya-Feldstein, J., Mar, J. C., Singh, R., Suda, T., Lin, C. P., Frenette, P. S. & Ito, K., Dec 2 2016, In : Science. 354, 6316, p. 1156-1160 5 p.

Research output: Contribution to journalArticle

103 Citations (Scopus)

Setdb1 maintains hematopoietic stem and progenitor cells by restricting the ectopic activation of nonhematopoietic genes

Koide, S., Oshima, M., Takubo, K., Yamazaki, S., Nitta, E., Saraya, A., Aoyama, K., Kato, Y., Miyagi, S., Nakajima-Takagi, Y., Chiba, T., Matsui, H., Arai, F., Suzuki, Y., Kimura, H., Nakauchi, H., Suda, T., Shinkai, Y. & Iwama, A., Aug 4 2016, In : Blood. 128, 5, p. 638-649 12 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)
2015

Determining c-Myb protein levels can isolate functional hematopoietic stem cell subtypes

Sakamoto, H., Takeda, N., Arai, F., Hosokawa, K., Garcia, P., Suda, T., Frampton, J. & Ogawa, M., Feb 1 2015, In : STEM CELLS. 33, 2, p. 479-490 12 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)
2013

Enhanced Angpt1/Tie2 signaling affects the differentiation and long-term repopulation ability of hematopoietic stem cells

Ikushima, Y. M., Arai, F., Nakamura, Y., Hosokawa, K., Kubota, Y., Hirashima, M., Toyama, H. & Suda, T., Jan 4 2013, In : Biochemical and Biophysical Research Communications. 430, 1, p. 20-25 6 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Nucleostemin is indispensable for the maintenance and genetic stability of hematopoietic stem cells

Yamashita, M., Nitta, E., Nagamatsu, G., Ikushima, Y. M., Hosokawa, K., Arai, F. & Suda, T., Nov 8 2013, In : Biochemical and Biophysical Research Communications. 441, 1, p. 196-201 6 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

OP9 Bone Marrow Stroma Cells Differentiate into Megakaryocytes and Platelets

Matsubara, Y., Ono, Y., Suzuki, H., Arai, F., Suda, T., Murata, M. & Ikeda, Y., Mar 1 2013, In : PloS one. 8, 3, e58123.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Prostaglandin E2 regulates murine hematopoietic stem/progenitor cells directly via EP4 receptor and indirectly through mesenchymal progenitor cells

Ikushima, Y. M., Arai, F., Hosokawa, K., Toyama, H., Takubo, K., Furuyashiki, T., Narumiya, S. & Suda, T., 2013, In : Blood. 121, 11, p. 1995-2007 13 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)
2012

A PML-PPAR-δ pathway for fatty acid oxidation regulates hematopoietic stem cell maintenance

Ito, K., Carracedo, A., Weiss, D., Arai, F., Ala, U., Avigan, D. E., Schafer, Z. T., Evans, R. M., Suda, T., Lee, C. H. & Pandolfi, P. P., Sep 2012, In : Nature medicine. 18, 9, p. 1350-1358 9 p.

Research output: Contribution to journalArticle

352 Citations (Scopus)

Gene expression profiling and regulatory networks in single cells

Arai, F., Hosokawa, K., Matsumoto, Y., Toyama, H. & Suda, T., Feb 1 2012, New Frontiers of Network Analysis in Systems Biology. Springer Netherlands, p. 1-13 13 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

N-cadherin+ HSCs in fetal liver exhibit higher long-term bone marrow reconstitution activity than N-cadherin- HSCs

Toyama, H., Arai, F., Hosokawa, K., Ikushima, Y. M. & Suda, T., Nov 23 2012, In : Biochemical and Biophysical Research Communications. 428, 3, p. 354-359 6 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Noncanonical Wnt signaling maintains hematopoietic stem cells in the niche

Sugimura, R., He, X. C., Venkatraman, A., Arai, F., Box, A., Semerad, C., Haug, J. S., Peng, L., Zhong, X. B., Suda, T. & Li, L., Jul 20 2012, In : Cell. 150, 2, p. 351-365 15 p.

Research output: Contribution to journalArticle

170 Citations (Scopus)

Role of N-cadherin in the regulation of hematopoietic stem cells in the bone marrow niche

Arai, F., Hosokawa, K., Toyama, H., Matsumoto, Y. & Suda, T., Jan 1 2012, In : Annals of the New York Academy of Sciences. 1266, 1, p. 72-77 6 p.

Research output: Contribution to journalArticle

32 Citations (Scopus)
2011

Impact of gene dosage, loss of wild-type allele, and FLT3 ligand on Flt3-ITD-induced myeloproliferation

Kharazi, S., Mead, A. J., Mansour, A., Hultquist, A., Böiers, C., Luc, S., Buza-Vidas, N., Ma, Z., Ferry, H., Atkinson, D., Reckzeh, K., Masson, K., Cammenga, J., Rönnstrand, L., Arai, F., Suda, T., Nerlov, C., Sitnicka, E. & Jacobsen, S. E. W., Sep 29 2011, In : Blood. 118, 13, p. 3613-3621 9 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

Telomerase reverse transcriptase protectsATM-deficient hematopoietic stem cells from ROS-induced apoptosis through a telomere-independent mechanism

Nitta, E., Yamashita, M., Hosokawa, K., Xian, M. J., Takubo, K., Arai, F., Nakada, S. & Suda, T., Apr 21 2011, In : Blood. 117, 16, p. 4169-4180 12 p.

Research output: Contribution to journalArticle

45 Citations (Scopus)
2010

Acquisition of G0 state by CD34-positive cord blood cells after bone marrow transplantation

Shima, H., Takubo, K., Tago, N., Iwasaki, H., Arai, F., Takahashi, T. & Suda, T., Dec 1 2010, In : Experimental Hematology. 38, 12, p. 1231-1240 10 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Cadherin-Based Adhesion Is a Potential Target for Niche Manipulation to Protect Hematopoietic Stem Cells in Adult Bone Marrow

Hosokawa, K., Arai, F., Yoshihara, H., Iwasaki, H., Hembree, M., Yin, T., Nakamura, Y., Gomei, Y., Takubo, K., Shiama, H., Matsuoka, S., Li, L. & Suda, T., Mar 5 2010, In : Cell stem cell. 6, 3, p. 194-198 5 p.

Research output: Contribution to journalLetter

73 Citations (Scopus)

Endothelial protein C receptor-expressing hematopoietic stem cells reside in the perisinusoidal niche in fetal liver

Iwasaki, H., Arai, F., Kubota, Y., Dahl, M. & Suda, T., Jul 29 2010, In : Blood. 116, 4, p. 544-553 10 p.

Research output: Contribution to journalArticle

60 Citations (Scopus)

Erratum: Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells (Nature Medicine (2006)12 (446-451))

Ito, K., Hirao, A., Arai, F., Takubo, K., Matsuoka, S., Miyamoto, K., Ohmura, M., Naka, K., Hosokawa, K., Ikeda, Y. & Suda, T., Jan 1 2010, In : Nature medicine. 16, 1, 1 p.

Research output: Contribution to journalComment/debate

2 Citations (Scopus)

Functional differences between two Tie2 ligands, angiopoietin-1 and -2, in regulation of adult bone marrow hematopoietic stem cells

Gomei, Y., Nakamura, Y., Yoshihara, H., Hosokawa, K., Iwasaki, H., Suda, T. & Arai, F., Jan 1 2010, In : Experimental Hematology. 38, 2

Research output: Contribution to journalArticle

26 Citations (Scopus)

Isolation and characterization of endosteal niche cell populations that regulate hematopoietic stem cells

Nakamura, Y., Arai, F., Iwasaki, H., Hosokawa, K., Kobayashi, I., Gomei, Y., Matsumoto, Y., Yoshihara, H. & Suda, T., Sep 2 2010, In : Blood. 116, 9, p. 1422-1432 11 p.

Research output: Contribution to journalArticle

140 Citations (Scopus)

Knockdown of N-cadherin suppresses the long-term engraftment of hematopoietic stem cells

Hosokawa, K., Arai, F., Yoshihara, H., Iwasaki, H., Nakamura, Y., Gomei, Y. & Suda, T., Jul 29 2010, In : Blood. 116, 4, p. 554-563 10 p.

Research output: Contribution to journalArticle

87 Citations (Scopus)

TIMP-3 recruits quiescent hematopoietic stem cells into active cell cycle and expands multipotent progenitor pool

Nakajima, H., Ito, M., Smookler, D. S., Shibata, F., Fukuchi, Y., Morikawa, Y., Ikeda, Y., Arai, F., Suda, T., Khokha, R. & Kitamura, T., Nov 25 2010, In : Blood. 116, 22, p. 4474-4482 9 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)
2009

Angiopoietins contribute to lung development by regulating pulmonary vascular network formation

Hato, T., Kimura, Y., Morisada, T., Koh, G. Y., Miyata, K., Tabata, M., Kadomatsu, T., Endo, M., Urano, T., Arai, F., Araki, K., Suda, T., Kobayashi, K. & Oike, Y., Apr 3 2009, In : Biochemical and Biophysical Research Communications. 381, 2, p. 218-223 6 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)

Interferon regulatory factor-2 protects quiescent hematopoietic stem cells from type i interferon-dependent exhaustion

Sato, T., Onai, N., Yoshihara, H., Arai, F., Suda, T. & Ohteki, T., Jun 8 2009, In : Nature medicine. 15, 6, p. 696-700 5 p.

Research output: Contribution to journalArticle

250 Citations (Scopus)

Niche regulation of hematopoietic stem cells in the endosteum: The role of thrombopoietinmpl signaling in the maintenance of quiescent Hematopoietic Stem Cells

Arai, F., Yoshihara, H., Hosokawa, K., Nakamura, Y., Gomei, Y., Iwasaki, H. & Suda, T., Jan 1 2009, Hematopoietic Stem Cells VII. Blackwell Publishing Inc., p. 36-46 11 p. (Annals of the New York Academy of Sciences; vol. 1176).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

49 Citations (Scopus)

Reconstitution activity of hypoxic cultured human cord blood CD34-positive cells in NOG mice

Shima, H., Takubo, K., Iwasaki, H., Yoshihara, H., Gomei, Y., Hosokawa, K., Arai, F., Takahashi, T. & Suda, T., Jan 16 2009, In : Biochemical and Biophysical Research Communications. 378, 3, p. 467-472 6 p.

Research output: Contribution to journalArticle

35 Citations (Scopus)
2008

Fbxw7 acts as a critical fail-safe against premature loss of hematopoietic stem cells and development of T-ALL

Matsuoka, S., Oike, Y., Onoyama, I., Iwama, A., Arai, F., Takubo, K., Mashimo, Y., Oguro, H., Nitta, E., Ito, K., Miyamoto, K., Yoshiwara, H., Hosokawa, K., Nakamura, Y., Gomei, Y., Iwasaki, H., Hayashi, Y., Matsuzaki, Y., Nakayama, K., Ikeda, Y. & 4 others, Hata, A., Chiba, S., Nakayama, K. I. & Suda, T., Apr 15 2008, In : Genes and Development. 22, 8, p. 986-991 6 p.

Research output: Contribution to journalArticle

131 Citations (Scopus)

Identification of stem cells during prepubertal spermatogenesis via monitoring of nucleostemin promoter activity

Ohmura, M., Naka, K., Hoshii, T., Muraguchi, T., Shugo, H., Tamase, A., Uema, N., Ooshio, T., Arai, F., Takubo, K., Nagamatsu, G., Hamaguchi, I., Takagi, M., Ishihara, M., Sakurada, K., Miyaji, H., Suda, T. & Hirao, A., Dec 2008, In : STEM CELLS. 26, 12, p. 3237-3246 10 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)

Stem Cell Defects in ATM-Deficient Undifferentiated Spermatogonia through DNA Damage-Induced Cell-Cycle Arrest

Takubo, K., Ohmura, M., Azuma, M., Nagamatsu, G., Yamada, W., Arai, F., Hirao, A. & Suda, T., Feb 7 2008, In : Cell stem cell. 2, 2, p. 170-182 13 p.

Research output: Contribution to journalArticle

97 Citations (Scopus)

Wnt Signaling in the Niche

Suda, T. & Arai, F., Mar 7 2008, In : Cell. 132, 5, p. 729-730 2 p.

Research output: Contribution to journalShort survey

36 Citations (Scopus)
2007

Foxo3a Is Essential for Maintenance of the Hematopoietic Stem Cell Pool

Miyamoto, K., Araki, K. Y., Naka, K., Arai, F., Takubo, K., Yamazaki, S., Matsuoka, S., Miyamoto, T., Ito, K., Ohmura, M., Chen, C., Hosokawa, K., Nakauchi, H., Nakayama, K., Nakayama, K. I., Harada, M., Motoyama, N., Suda, T. & Hirao, A., Jun 7 2007, In : Cell stem cell. 1, 1, p. 101-112 12 p.

Research output: Contribution to journalArticle

583 Citations (Scopus)

Function of oxidative stress in the regulation of hematopoietic stem cell-niche interaction

Hosokawa, K., Arai, F., Yoshihara, H., Nakamura, Y., Gomei, Y., Iwasaki, H., Miyamoto, K., Shima, H., Ito, K. & Suda, T., Nov 23 2007, In : Biochemical and Biophysical Research Communications. 363, 3, p. 578-583 6 p.

Research output: Contribution to journalArticle

92 Citations (Scopus)

Homing, proliferation and survival sites of human leukemia cells in vivo in immunodeficient mice

Ninomiya, M., Abe, A., Katsumi, A., Xu, J., Ito, M., Arai, F., Suda, T., Ito, M., Kiyoi, H., Kinoshita, T. & Naoe, T., Jan 2007, In : Leukemia. 21, 1, p. 136-142 7 p.

Research output: Contribution to journalArticle

74 Citations (Scopus)

Maintenance of quiescent hematopoietic stem cells in the osteoblastic niche

Arai, F. & Suda, T., Jun 2007, Hematopoietic Stem Cells VI. Blackwell Publishing Inc., p. 41-53 13 p. (Annals of the New York Academy of Sciences; vol. 1106).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

180 Citations (Scopus)

Regulation of reactive oxygen species by Atm is essential for proper response to DNA double-strand breaks in lymphocytes

Ito, K., Takubo, K., Arai, F., Satoh, H., Matsuoka, S., Ohmura, M., Naka, K., Azuma, M., Miyamoto, K., Hosokawa, K., Ikeda, Y., Mak, T. W., Suda, T. & Hirao, A., Jan 1 2007, In : Journal of Immunology. 178, 1, p. 103-110 8 p.

Research output: Contribution to journalArticle

88 Citations (Scopus)

Thrombopoietin/MPL Signaling Regulates Hematopoietic Stem Cell Quiescence and Interaction with the Osteoblastic Niche

Yoshihara, H., Arai, F., Hosokawa, K., Hagiwara, T., Takubo, K., Nakamura, Y., Gomei, Y., Iwasaki, H., Matsuoka, S., Miyamoto, K., Miyazaki, H., Takahashi, T. & Suda, T., Dec 13 2007, In : Cell stem cell. 1, 6, p. 685-697 13 p.

Research output: Contribution to journalArticle

472 Citations (Scopus)
2006

Premeiotic germ cell defect in seminiferous tubules of Atm-null testis

Takubo, K., Hirao, A., Ohmura, M., Azuma, M., Arai, F., Nagamatsu, G. & Suda, T., Dec 29 2006, In : Biochemical and Biophysical Research Communications. 351, 4, p. 993-998 6 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells

Ito, K., Hirao, A., Arai, F., Takubo, K., Matsuoka, S., Miyamoto, K., Ohmura, M., Naka, K., Hosokawa, K., Ikeda, Y. & Suda, T., Apr 2006, In : Nature medicine. 12, 4, p. 446-451 6 p.

Research output: Contribution to journalArticle

917 Citations (Scopus)

Regulation of Hematopoietic Stem Cells and Interactions with Stem Cell Niche

Arai, F., Jan 1 2006, In : journal of oral biosciences. 48, 1, p. 22-29 8 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)