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Research Output 1998 2019

2019
9 Citations (Scopus)

Cell-based screen identifies a new potent and highly selective CK2 inhibitor for modulation of circadian rhythms and cancer cell growth

Oshima, T., Niwa, Y., Kuwata, K., Srivastava, A., Hyoda, T., Tsuchiya, Y., Kumagai, M., Tsuyuguchi, M., Tamaru, T., Sugiyama, A., Ono, N., Zolboot, N., Aikawa, Y., Oishi, S., Nonami, A., Arai, F., Hagihara, S., Yamaguchi, J., Tama, F., Kunisaki, Y. & 6 others, Yagita, K., Ikeda, M., Kinoshita, T., Kay, S. A., Itami, K. & Hirota, T., Jan 23 2019, In : Science Advances. 5, 1, eaau9060.

Research output: Contribution to journalArticle

Open Access
Circadian Rhythm
Circadian Clocks
Phosphotransferases
Growth
Neoplasms

Environmental Optimization Enables Maintenance of Quiescent Hematopoietic Stem Cells Ex Vivo

Kobayashi, H., Morikawa, T., Okinaga, A., Hamano, F., Hashidate-Yoshida, T., Watanuki, S., Hishikawa, D., Shindou, H., Arai, F., Kabe, Y., Suematsu, M., Shimizu, T. & Takubo, K., Jul 2 2019, In : Cell Reports. 28, 1, p. 145-158.e9

Research output: Contribution to journalArticle

Open Access
Hematopoietic Stem Cells
Stem cells
Maintenance
Fatty Acids
Cell culture
2 Citations (Scopus)

Regnase-1-mediated post-transcriptional regulation is essential for hematopoietic stem and progenitor cell homeostasis

Kidoya, H., Muramatsu, F., Shimamura, T., Jia, W., Satoh, T., Hayashi, Y., Naito, H., Kunisaki, Y., Arai, F., Seki, M., Suzuki, Y., Osawa, T., Akira, S. & Takakura, N., Dec 1 2019, In : Nature communications. 10, 1, 1072.

Research output: Contribution to journalArticle

Open Access
homeostasis
stem cells
Hematopoietic Stem Cells
Homeostasis
hematopoiesis
2018
15 Citations (Scopus)

Genome-wide CRISPR-Cas9 Screen Identifies Leukemia-Specific Dependence on a Pre-mRNA Metabolic Pathway Regulated by DCPS

yamauchi, T., Masuda, T., Canver, M. C., Seiler, M., Semba, Y., Shboul, M., Al-Raqad, M., Maeda, M., Schoonenberg, V. A. C., Cole, M. A., Macias-Trevino, C., Ishikawa, Y., Yao, Q., Nakano, M., Arai, F., Orkin, S. H., Reversade, B., Buonamici, S., Pinello, L., Akashi, K. & 2 others, Bauer, D. E. & Maeda, T., Mar 12 2018, In : Cancer Cell. 33, 3, p. 386-400.e5

Research output: Contribution to journalArticle

Clustered Regularly Interspaced Short Palindromic Repeats
RNA Precursors
Metabolic Networks and Pathways
Leukemia
Genome

Guest editorial: Regulatory signaling in normal and abnormal hematopoiesis

Arai, F., Jun 1 2018, In : International journal of hematology. 107, 6, p. 624-626 3 p.

Research output: Contribution to journalEditorial

Hematopoiesis
Hematopoietic Stem Cells
Stem Cells
Stem Cell Niche
Maintenance
5 Citations (Scopus)

Spred1 Safeguards Hematopoietic Homeostasis against Diet-Induced Systemic Stress

Tadokoro, Y., Hoshii, T., Yamazaki, S., Eto, K., Ema, H., Kobayashi, M., Ueno, M., Ohta, K., Arai, Y., Hara, E., Harada, K., Oshima, M., Oshima, H., Arai, F., Yoshimura, A., Nakauchi, H. & Hirao, A., May 3 2018, In : Cell stem cell. 22, 5, p. 713-725.e8

Research output: Contribution to journalArticle

Hematopoietic Stem Cells
Homeostasis
Diet
High Fat Diet
Dysbiosis
3 Citations (Scopus)

The role of telomere binding molecules for normal and abnormal hematopoiesis

Hosokawa, K. & Arai, F., Jun 1 2018, In : International journal of hematology. 107, 6, p. 646-655 10 p.

Research output: Contribution to journalReview article

Telomere
Hematopoiesis
Hematopoietic Stem Cells
Hematopoietic System
DNA Damage
2017
2 Citations (Scopus)

Functional dissection of hematopoietic stem cell populations with a stemness-monitoring system based on NS-GFP transgene expression

Ali, M. A. E., Fuse, K., Tadokoro, Y., Hoshii, T., Ueno, M., Kobayashi, M., Nomura, N., Vu, H. T., Peng, H., Hegazy, A. M., Masuko, M., Sone, H., Arai, F., Tajima, A. & Hirao, A., Dec 1 2017, In : Scientific reports. 7, 1, 11442.

Research output: Contribution to journalArticle

Hematopoietic Stem Cells
Transgenes
Dissection
Population
Proteins
19 Citations (Scopus)

Stem Cell Differentiation as a Non-Markov Stochastic Process

Stumpf, P. S., Smith, R. C. G., Lenz, M., Schuppert, A., Müller, F. J., Babtie, A., Chan, T. E., Stumpf, M. P. H., Please, C. P., Howison, S. D., Arai, F. & MacArthur, B. D., Sep 27 2017, In : Cell Systems. 5, 3, p. 268-282.e7

Research output: Contribution to journalArticle

Stochastic Processes
Cell Differentiation
Stem Cells
Mechanics
Germ Layers
8 Citations (Scopus)

The telomere binding protein Pot1 maintains haematopoietic stem cell activity with age

Hosokawa, K., MacArthur, B. D., Ikushima, Y. M., Toyama, H., Masuhiro, Y., Hanazawa, S., Suda, T. & Arai, F., Dec 1 2017, In : Nature communications. 8, 1, 804.

Research output: Contribution to journalArticle

Telomere-Binding Proteins
telomeres
stem cells
Telomere
Hematopoietic Stem Cells
2016
1 Citation (Scopus)

Self-renewal and differentiation of hematopoietic stem cells

Arai, F., Jan 1 2016, In : [Rinsho ketsueki] The Japanese journal of clinical hematology. 57, 10, p. 1845-1851 7 p.

Research output: Contribution to journalArticle

Hematopoietic Stem Cells
Stem Cells
Parturition
Single-Cell Analysis
Stochastic Processes
87 Citations (Scopus)

Self-renewal of a purified Tie2+ hematopoietic stem cell population relies on mitochondrial clearance

Ito, K., Turcotte, R., Cui, J., Zimmerman, S. E., Pinho, S., Mizoguchi, T., Arai, F., Runnels, J. M., Alt, C., Teruya-Feldstein, J., Mar, J. C., Singh, R., Suda, T., Lin, C. P., Frenette, P. S. & Ito, K., Dec 2 2016, In : Science. 354, 6316, p. 1156-1160 5 p.

Research output: Contribution to journalArticle

Hematopoietic Stem Cells
Mitochondrial Degradation
Metabolic Networks and Pathways
Population
Mitochondria
19 Citations (Scopus)

Setdb1 maintains hematopoietic stem and progenitor cells by restricting the ectopic activation of nonhematopoietic genes

Koide, S., Oshima, M., Takubo, K., Yamazaki, S., Nitta, E., Saraya, A., Aoyama, K., Kato, Y., Miyagi, S., Nakajima-Takagi, Y., Chiba, T., Matsui, H., Arai, F., Suzuki, Y., Kimura, H., Nakauchi, H., Suda, T., Shinkai, Y. & Iwama, A., Aug 4 2016, In : Blood. 128, 5, p. 638-649 12 p.

Research output: Contribution to journalArticle

Hematopoietic Stem Cells
Stem cells
Transcriptional Activation
Genes
Chemical activation
2015
6 Citations (Scopus)

Determining c-Myb protein levels can isolate functional hematopoietic stem cell subtypes

Sakamoto, H., Takeda, N., Arai, F., Hosokawa, K., Garcia, P., Suda, T., Frampton, J. & Ogawa, M., Feb 1 2015, In : STEM CELLS. 33, 2, p. 479-490 12 p.

Research output: Contribution to journalArticle

Proto-Oncogene Proteins c-myb
Hematopoietic Stem Cells
Oncogene Proteins
Hematopoiesis
Bromodeoxyuridine
2013
9 Citations (Scopus)

Enhanced Angpt1/Tie2 signaling affects the differentiation and long-term repopulation ability of hematopoietic stem cells

Ikushima, Y. M., Arai, F., Nakamura, Y., Hosokawa, K., Kubota, Y., Hirashima, M., Toyama, H. & Suda, T., Jan 4 2013, In : Biochemical and Biophysical Research Communications. 430, 1, p. 20-25 6 p.

Research output: Contribution to journalArticle

Angiopoietin-1
Hematopoietic Stem Cells
Stem cells
Transgenic Mice
Hematopoiesis
17 Citations (Scopus)

Nucleostemin is indispensable for the maintenance and genetic stability of hematopoietic stem cells

Yamashita, M., Nitta, E., Nagamatsu, G., Ikushima, Y. M., Hosokawa, K., Arai, F. & Suda, T., Nov 8 2013, In : Biochemical and Biophysical Research Communications. 441, 1, p. 196-201 6 p.

Research output: Contribution to journalArticle

Hematopoietic Stem Cells
Stem cells
Maintenance
DNA Damage
Apoptosis
9 Citations (Scopus)

OP9 Bone Marrow Stroma Cells Differentiate into Megakaryocytes and Platelets

Matsubara, Y., Ono, Y., Suzuki, H., Arai, F., Suda, T., Murata, M. & Ikeda, Y., Mar 1 2013, In : PloS one. 8, 3, e58123.

Research output: Contribution to journalArticle

megakaryocytes
Megakaryocytes
Platelets
Bone Marrow Cells
bone marrow
24 Citations (Scopus)

Prostaglandin E2 regulates murine hematopoietic stem/progenitor cells directly via EP4 receptor and indirectly through mesenchymal progenitor cells

Ikushima, Y. M., Arai, F., Hosokawa, K., Toyama, H., Takubo, K., Furuyashiki, T., Narumiya, S. & Suda, T., Jan 1 2013, In : Blood. 121, 11, p. 1995-2007 13 p.

Research output: Contribution to journalArticle

Hematopoietic Stem Cells
Stem cells
Mesenchymal Stromal Cells
Dinoprostone
Recovery
2012
292 Citations (Scopus)

A PML-PPAR-δ pathway for fatty acid oxidation regulates hematopoietic stem cell maintenance

Ito, K., Carracedo, A., Weiss, D., Arai, F., Ala, U., Avigan, D. E., Schafer, Z. T., Evans, R. M., Suda, T., Lee, C. H. & Pandolfi, P. P., Sep 1 2012, In : Nature medicine. 18, 9, p. 1350-1358 9 p.

Research output: Contribution to journalArticle

Peroxisome Proliferator-Activated Receptors
Hematopoietic Stem Cells
Stem cells
Leukemia
Fatty Acids

Gene expression profiling and regulatory networks in single cells

Arai, F., Hosokawa, K., Matsumoto, Y., Toyama, H. & Suda, T., Feb 1 2012, New Frontiers of Network Analysis in Systems Biology. Springer Netherlands, p. 1-13 13 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Gene Expression Profiling
Gene Expression
Population
Complementary DNA
DNA Sequence Analysis
3 Citations (Scopus)

N-cadherin+ HSCs in fetal liver exhibit higher long-term bone marrow reconstitution activity than N-cadherin- HSCs

Toyama, H., Arai, F., Hosokawa, K., Ikushima, Y. M. & Suda, T., Nov 23 2012, In : Biochemical and Biophysical Research Communications. 428, 3, p. 354-359 6 p.

Research output: Contribution to journalArticle

Cadherins
Hematopoietic Stem Cells
Stem cells
Liver
Bone
165 Citations (Scopus)

Noncanonical Wnt signaling maintains hematopoietic stem cells in the niche

Sugimura, R., He, X. C., Venkatraman, A., Arai, F., Box, A., Semerad, C., Haug, J. S., Peng, L., Zhong, X. B., Suda, T. & Li, L., Jul 20 2012, In : Cell. 150, 2, p. 351-365 15 p.

Research output: Contribution to journalArticle

Stem Cell Niche
Hematopoietic Stem Cells
Stem cells
Cadherins
Osteoblasts
30 Citations (Scopus)

Role of N-cadherin in the regulation of hematopoietic stem cells in the bone marrow niche

Arai, F., Hosokawa, K., Toyama, H., Matsumoto, Y. & Suda, T., Jan 1 2012, In : Annals of the New York Academy of Sciences. 1266, 1, p. 72-77 6 p.

Research output: Contribution to journalArticle

Cadherins
Hematopoietic Stem Cells
Stem cells
Bone
Bone Marrow
2011
21 Citations (Scopus)

Impact of gene dosage, loss of wild-type allele, and FLT3 ligand on Flt3-ITD-induced myeloproliferation

Kharazi, S., Mead, A. J., Mansour, A., Hultquist, A., Böiers, C., Luc, S., Buza-Vidas, N., Ma, Z., Ferry, H., Atkinson, D., Reckzeh, K., Masson, K., Cammenga, J., Rönnstrand, L., Arai, F., Suda, T., Nerlov, C., Sitnicka, E. & Jacobsen, S. E. W., Sep 29 2011, In : Blood. 118, 13, p. 3613-3621 9 p.

Research output: Contribution to journalArticle

Gene Dosage
Genes
Alleles
Ligands
Phenotype
41 Citations (Scopus)

Telomerase reverse transcriptase protectsATM-deficient hematopoietic stem cells from ROS-induced apoptosis through a telomere-independent mechanism

Nitta, E., Yamashita, M., Hosokawa, K., Xian, M. J., Takubo, K., Arai, F., Nakada, S. & Suda, T., Apr 21 2011, In : Blood. 117, 16, p. 4169-4180 12 p.

Research output: Contribution to journalArticle

Telomerase
Telomere
Hematopoietic Stem Cells
Stem cells
Reactive Oxygen Species
2010
20 Citations (Scopus)

Acquisition of G0 state by CD34-positive cord blood cells after bone marrow transplantation

Shima, H., Takubo, K., Tago, N., Iwasaki, H., Arai, F., Takahashi, T. & Suda, T., Dec 1 2010, In : Experimental Hematology. 38, 12, p. 1231-1240 10 p.

Research output: Contribution to journalArticle

Hematopoietic Stem Cells
Bone Marrow Transplantation
Fetal Blood
Blood Cells
Cell Cycle
70 Citations (Scopus)

Cadherin-Based Adhesion Is a Potential Target for Niche Manipulation to Protect Hematopoietic Stem Cells in Adult Bone Marrow

Hosokawa, K., Arai, F., Yoshihara, H., Iwasaki, H., Hembree, M., Yin, T., Nakamura, Y., Gomei, Y., Takubo, K., Shiama, H., Matsuoka, S., Li, L. & Suda, T., Mar 5 2010, In : Cell stem cell. 6, 3, p. 194-198 5 p.

Research output: Contribution to journalLetter

Stem Cell Niche
Gene Expression Regulation
Cadherins
Hematopoietic Stem Cells
Cell Adhesion
58 Citations (Scopus)

Endothelial protein C receptor-expressing hematopoietic stem cells reside in the perisinusoidal niche in fetal liver

Iwasaki, H., Arai, F., Kubota, Y., Dahl, M. & Suda, T., Jul 29 2010, In : Blood. 116, 4, p. 544-553 10 p.

Research output: Contribution to journalArticle

Hematopoietic Stem Cells
Protein C
Stem cells
Liver
PAR-1 Receptor
2 Citations (Scopus)

Erratum: Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells (Nature Medicine (2006)12 (446-451))

Ito, K., Hirao, A., Arai, F., Takubo, K., Matsuoka, S., Miyamoto, K., Ohmura, M., Naka, K., Hosokawa, K., Ikeda, Y. & Suda, T., Jan 1 2010, In : Nature medicine. 16, 1, 1 p.

Research output: Contribution to journalComment/debate

p38 Mitogen-Activated Protein Kinases
Hematopoietic Stem Cells
Reactive Oxygen Species
Medicine
25 Citations (Scopus)

Functional differences between two Tie2 ligands, angiopoietin-1 and -2, in regulation of adult bone marrow hematopoietic stem cells

Gomei, Y., Nakamura, Y., Yoshihara, H., Hosokawa, K., Iwasaki, H., Suda, T. & Arai, F., Jan 1 2010, In : Experimental Hematology. 38, 2

Research output: Contribution to journalArticle

Angiopoietin-2
Angiopoietin-1
Hematopoietic Stem Cells
Bone Marrow
Ligands
134 Citations (Scopus)

Isolation and characterization of endosteal niche cell populations that regulate hematopoietic stem cells

Nakamura, Y., Arai, F., Iwasaki, H., Hosokawa, K., Kobayashi, I., Gomei, Y., Matsumoto, Y., Yoshihara, H. & Suda, T., Sep 2 2010, In : Blood. 116, 9, p. 1422-1432 11 p.

Research output: Contribution to journalArticle

Activated-Leukocyte Cell Adhesion Molecule
Hematopoietic Stem Cells
Stem cells
Cells
Population
83 Citations (Scopus)

Knockdown of N-cadherin suppresses the long-term engraftment of hematopoietic stem cells

Hosokawa, K., Arai, F., Yoshihara, H., Iwasaki, H., Nakamura, Y., Gomei, Y. & Suda, T., Jul 29 2010, In : Blood. 116, 4, p. 554-563 10 p.

Research output: Contribution to journalArticle

Cadherins
Hematopoietic Stem Cells
Stem cells
Small Interfering RNA
Bone
22 Citations (Scopus)

TIMP-3 recruits quiescent hematopoietic stem cells into active cell cycle and expands multipotent progenitor pool

Nakajima, H., Ito, M., Smookler, D. S., Shibata, F., Fukuchi, Y., Morikawa, Y., Ikeda, Y., Arai, F., Suda, T., Khokha, R. & Kitamura, T., Nov 25 2010, In : Blood. 116, 22, p. 4474-4482 9 p.

Research output: Contribution to journalArticle

Tissue Inhibitor of Metalloproteinase-3
Hematopoietic Stem Cells
Stem cells
Cell Cycle
Cells
2009
23 Citations (Scopus)

Angiopoietins contribute to lung development by regulating pulmonary vascular network formation

Hato, T., Kimura, Y., Morisada, T., Koh, G. Y., Miyata, K., Tabata, M., Kadomatsu, T., Endo, M., Urano, T., Arai, F., Araki, K., Suda, T., Kobayashi, K. & Oike, Y., Apr 3 2009, In : Biochemical and Biophysical Research Communications. 381, 2, p. 218-223 6 p.

Research output: Contribution to journalArticle

Angiopoietins
Blood Vessels
Lung
TIE-2 Receptor
Parturition
233 Citations (Scopus)

Interferon regulatory factor-2 protects quiescent hematopoietic stem cells from type i interferon-dependent exhaustion

Sato, T., Onai, N., Yoshihara, H., Arai, F., Suda, T. & Ohteki, T., Jun 8 2009, In : Nature medicine. 15, 6, p. 696-700 5 p.

Research output: Contribution to journalArticle

Interferon Regulatory Factor-2
Interferon Type I
Hematopoietic Stem Cells
Stem cells
Interferons
47 Citations (Scopus)

Niche regulation of hematopoietic stem cells in the endosteum: The role of thrombopoietinmpl signaling in the maintenance of quiescent Hematopoietic Stem Cells

Arai, F., Yoshihara, H., Hosokawa, K., Nakamura, Y., Gomei, Y., Iwasaki, H. & Suda, T., Jan 1 2009, Hematopoietic Stem Cells VII. Blackwell Publishing Inc., p. 36-46 11 p. (Annals of the New York Academy of Sciences; vol. 1176).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Hematopoietic Stem Cells
Stem cells
Maintenance
Bone
Stem Cell Niche
35 Citations (Scopus)

Reconstitution activity of hypoxic cultured human cord blood CD34-positive cells in NOG mice

Shima, H., Takubo, K., Iwasaki, H., Yoshihara, H., Gomei, Y., Hosokawa, K., Arai, F., Takahashi, T. & Suda, T., Jan 16 2009, In : Biochemical and Biophysical Research Communications. 378, 3, p. 467-472 6 p.

Research output: Contribution to journalArticle

Hematopoietic Stem Cells
Stem cells
Fetal Blood
Blood
Cells
2008
118 Citations (Scopus)

Fbxw7 acts as a critical fail-safe against premature loss of hematopoietic stem cells and development of T-ALL

Matsuoka, S., Oike, Y., Onoyama, I., Iwama, A., Arai, F., Takubo, K., Mashimo, Y., Oguro, H., Nitta, E., Ito, K., Miyamoto, K., Yoshiwara, H., Hosokawa, K., Nakamura, Y., Gomei, Y., Iwasaki, H., Hayashi, Y., Matsuzaki, Y., Nakayama, K., Ikeda, Y. & 4 others, Hata, A., Chiba, S., Nakayama, K. I. & Suda, T., Apr 15 2008, In : Genes and Development. 22, 8, p. 986-991 6 p.

Research output: Contribution to journalArticle

Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Hematopoietic Stem Cells
SKP Cullin F-Box Protein Ligases
Cell Cycle
Leukemia
28 Citations (Scopus)

Identification of stem cells during prepubertal spermatogenesis via monitoring of nucleostemin promoter activity

Ohmura, M., Naka, K., Hoshii, T., Muraguchi, T., Shugo, H., Tamase, A., Uema, N., Ooshio, T., Arai, F., Takubo, K., Nagamatsu, G., Hamaguchi, I., Takagi, M., Ishihara, M., Sakurada, K., Miyaji, H., Suda, T. & Hirao, A., Dec 1 2008, In : STEM CELLS. 26, 12, p. 3237-3246 10 p.

Research output: Contribution to journalArticle

Spermatogenesis
Green Fluorescent Proteins
Stem Cells
Testis
Germ Cells
95 Citations (Scopus)

Stem Cell Defects in ATM-Deficient Undifferentiated Spermatogonia through DNA Damage-Induced Cell-Cycle Arrest

Takubo, K., Ohmura, M., Azuma, M., Nagamatsu, G., Yamada, W., Arai, F., Hirao, A. & Suda, T., Feb 7 2008, In : Cell stem cell. 2, 2, p. 170-182 13 p.

Research output: Contribution to journalArticle

Spermatogonia
Cell Cycle Checkpoints
DNA Damage
Stem Cells
Spermatogenesis
34 Citations (Scopus)

Wnt Signaling in the Niche

Suda, T. & Arai, F., Mar 7 2008, In : Cell. 132, 5, p. 729-730 2 p.

Research output: Contribution to journalShort survey

Hematopoietic Stem Cells
Stem cells
Bone Marrow
Hematopoietic System
Catenins
2007
558 Citations (Scopus)

Foxo3a Is Essential for Maintenance of the Hematopoietic Stem Cell Pool

Miyamoto, K., Araki, K. Y., Naka, K., Arai, F., Takubo, K., Yamazaki, S., Matsuoka, S., Miyamoto, T., Ito, K., Ohmura, M., Chen, C., Hosokawa, K., Nakauchi, H., Nakayama, K., Nakayama, K. I., Harada, M., Motoyama, N., Suda, T. & Hirao, A., Jun 7 2007, In : Cell stem cell. 1, 1, p. 101-112 12 p.

Research output: Contribution to journalArticle

Hematopoietic Stem Cells
Maintenance
Forkhead Transcription Factors
Critical Pathways
Hematopoiesis
90 Citations (Scopus)

Function of oxidative stress in the regulation of hematopoietic stem cell-niche interaction

Hosokawa, K., Arai, F., Yoshihara, H., Nakamura, Y., Gomei, Y., Iwasaki, H., Miyamoto, K., Shima, H., Ito, K. & Suda, T., Nov 23 2007, In : Biochemical and Biophysical Research Communications. 363, 3, p. 578-583 6 p.

Research output: Contribution to journalArticle

Stem Cell Niche
Oxidative stress
Hematopoietic Stem Cells
Stem cells
Cell Communication
72 Citations (Scopus)

Homing, proliferation and survival sites of human leukemia cells in vivo in immunodeficient mice

Ninomiya, M., Abe, A., Katsumi, A., Xu, J., Ito, M., Arai, F., Suda, T., Ito, M., Kiyoi, H., Kinoshita, T. & Naoe, T., Jan 1 2007, In : Leukemia. 21, 1, p. 136-142 7 p.

Research output: Contribution to journalArticle

Leukemia
Survival
Fetal Blood
Blood Cells
Stem Cell Niche
176 Citations (Scopus)

Maintenance of quiescent hematopoietic stem cells in the osteoblastic niche

Arai, F. & Suda, T., Jan 1 2007, Hematopoietic Stem Cells VI. Blackwell Publishing Inc., p. 41-53 13 p. (Annals of the New York Academy of Sciences; vol. 1106).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Hematopoietic Stem Cells
Stem cells
Maintenance
Bone Marrow
Stem Cell Niche
86 Citations (Scopus)

Regulation of reactive oxygen species by Atm is essential for proper response to DNA double-strand breaks in lymphocytes

Ito, K., Takubo, K., Arai, F., Satoh, H., Matsuoka, S., Ohmura, M., Naka, K., Azuma, M., Miyamoto, K., Hosokawa, K., Ikeda, Y., Mak, T. W., Suda, T. & Hirao, A., Jan 1 2007, In : Journal of Immunology. 178, 1, p. 103-110 8 p.

Research output: Contribution to journalArticle

Double-Stranded DNA Breaks
Reactive Oxygen Species
Lymphocytes
Acetylcysteine
Genetic Recombination
445 Citations (Scopus)

Thrombopoietin/MPL Signaling Regulates Hematopoietic Stem Cell Quiescence and Interaction with the Osteoblastic Niche

Yoshihara, H., Arai, F., Hosokawa, K., Hagiwara, T., Takubo, K., Nakamura, Y., Gomei, Y., Iwasaki, H., Matsuoka, S., Miyamoto, K., Miyazaki, H., Takahashi, T. & Suda, T., Dec 13 2007, In : Cell stem cell. 1, 6, p. 685-697 13 p.

Research output: Contribution to journalArticle

Thrombopoietin
Hematopoietic Stem Cells
Cell Communication
Thrombopoietin Receptors
CDC2 Protein Kinase
2006
17 Citations (Scopus)

Premeiotic germ cell defect in seminiferous tubules of Atm-null testis

Takubo, K., Hirao, A., Ohmura, M., Azuma, M., Arai, F., Nagamatsu, G. & Suda, T., Dec 29 2006, In : Biochemical and Biophysical Research Communications. 351, 4, p. 993-998 6 p.

Research output: Contribution to journalArticle

Seminiferous Tubules
Germ Cells
Ataxia Telangiectasia
Testis
Cells
872 Citations (Scopus)

Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells

Ito, K., Hirao, A., Arai, F., Takubo, K., Matsuoka, S., Miyamoto, K., Ohmura, M., Naka, K., Hosokawa, K., Ikeda, Y. & Suda, T., Apr 1 2006, In : Nature medicine. 12, 4, p. 446-451 6 p.

Research output: Contribution to journalArticle

p38 Mitogen-Activated Protein Kinases
Hematopoietic Stem Cells
Stem cells
Reactive Oxygen Species
Maintenance
1 Citation (Scopus)

Regulation of Hematopoietic Stem Cells and Interactions with Stem Cell Niche

Arai, F., Jan 1 2006, In : journal of oral biosciences. 48, 1, p. 22-29 8 p.

Research output: Contribution to journalArticle

Stem Cell Niche
Hematopoietic Stem Cells
Stem cells
Cell Communication
Bone