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Research Output 1995 2019

  • 1243 Citations
  • 22 h-Index
  • 67 Article
  • 2 Chapter
  • 2 Review article
  • 1 Short survey
2019
1 Citation (Scopus)

Acetylsalicylic Acid Treatment and Suppressive Regulation of AKT Accelerate Odontogenic Differentiation of Stem Cells from the Apical Papilla

Tanaka, Y., Sonoda, S., Yamaza, H., Murata, S., Nishida, K., Kyumoto, Y., Uehara, N., Nonaka, K., Kukita, T. & Yamaza, T., May 1 2019, In : Journal of Endodontics. 45, 5, p. 591-598.e6

Research output: Contribution to journalArticle

Aspirin
Stem Cells
Tooth Root
NFI Transcription Factors
Small Interfering RNA
1 Citation (Scopus)
Dental Pulp
Oxidative stress
Deciduous Tooth
Stem cells
Folic Acid
Open Access
Dental Pulp
Stem cells
Pulp
Stem Cells
Mutation
Leigh Disease
Bezafibrate
Deciduous Tooth
Organelle Biogenesis
Stem cells
1 Citation (Scopus)
Dental Pulp
Dopaminergic Neurons
Brain-Derived Neurotrophic Factor
Neurites
Attention Deficit Disorder with Hyperactivity
1 Citation (Scopus)

Regenerative medicine using stem cells from human exfoliated deciduous teeth (SHED): a promising new treatment in pediatric surgery

Taguchi, T., Yanagi, Y., Yoshimaru, K., Zhang, X. Y., Matsuura, T., Nakayama, K., Kobayashi, E., Yamaza, H., Nonaka, K., Ohga, S. & Yamaza, T., Apr 10 2019, In : Surgery today. 49, 4, p. 316-322 7 p.

Research output: Contribution to journalReview article

Biliary Atresia
Diaphragmatic Hernia
Regenerative Medicine
Deciduous Tooth
Three-Dimensional Imaging
1 Citation (Scopus)
Open Access
Hepatolenticular Degeneration
Deciduous Tooth
Inbred LEC Rats
Hepatocytes
Stem Cells
2018
1 Citation (Scopus)
Dentinogenesis
Mitochondrial Dynamics
Dynamins
Dental Papilla
Odontoblasts
1 Citation (Scopus)

Altered development of dopaminergic neurons differentiated from stem cells from human exfoliated deciduous teeth of a patient with Down syndrome

Pham, T. T. M., Kato, H., Yamaza, H., Masuda, K., Hirofuji, Y., Sato, H., Nguyen, H. T. N., Han, X., Zhang, Y., Taguchi, T. & Nonaka, K., Aug 31 2018, In : BMC neurology. 18, 1, 132.

Research output: Contribution to journalArticle

Deciduous Tooth
Dopaminergic Neurons
Down Syndrome
Stem Cells
Dopamine
2 Citations (Scopus)

Bilirubin reversibly affects cell death and odontogenic capacity in stem cells from human exfoliated deciduous teeth

Yamaza, H., Tomoda, E., Sonoda, S., Nonaka, K., Kukita, T. & Yamaza, T., Jul 1 2018, In : Oral Diseases. 24, 5, p. 809-819 11 p.

Research output: Contribution to journalArticle

Deciduous Tooth
Bilirubin
Cell Death
Stem Cells
Mitogen-Activated Protein Kinase 3
4 Citations (Scopus)

Exogenous nitric oxide stimulates the odontogenic differentiation of rat dental pulp stem cells

Sonoda, S., Mei, Y. F., Ikiru, A., Danjo, A., Yamaza, H., Hama, S., Nishida, K., Tang, R., Kyumoto, Y., Uehara, N., Kukita, T., Nishimura, F. & Yamaza, T., Dec 1 2018, In : Scientific reports. 8, 1, 3419.

Research output: Contribution to journalArticle

Dental Pulp
Nitric Oxide
Stem Cells
Odontoblasts
Dentin
1 Citation (Scopus)
Deciduous Tooth
Dopaminergic Neurons
Neurites
Stem cells
Neurons
4 Citations (Scopus)
Methyl-CpG-Binding Protein 2
Rett Syndrome
Deciduous Tooth
Dopaminergic Neurons
Stem cells
1 Citation (Scopus)
pamidronate
Hyperbilirubinemia
Deciduous Tooth
Cell death
Stem cells
4 Citations (Scopus)

Suppression of AKT-mTOR signal pathway enhances osteogenic/dentinogenic capacity of stem cells from apical papilla

Tanaka, Y., Sonoda, S., Yamaza, H., Murata, S., Nishida, K., Hama, S., Kyumoto, Y., Uehara, N., Nonaka, K., Kukita, T. & Yamaza, T., Nov 29 2018, In : Stem Cell Research and Therapy. 9, 1, 334.

Research output: Contribution to journalArticle

Sirolimus
Stem cells
Signal Transduction
Stem Cells
1-Phosphatidylinositol 4-Kinase
2017
8 Citations (Scopus)

Direct effects of mitochondrial dysfunction on poor bone health in Leigh syndrome

Kato, H., Han, X., Yamaza, H., Masuda, K., Hirofuji, Y., Sato, H., Pham, T. T. M., Taguchi, T. & Nonaka, K., Nov 4 2017, In : Biochemical and Biophysical Research Communications. 493, 1, p. 207-212 6 p.

Research output: Contribution to journalArticle

Leigh Disease
Mitochondrial Diseases
Bone
Health
Bone and Bones

Engineering of Systematic Elimination of a Targeted Chromosome in Human Cells

Sato, H., Kato, H., Yamaza, H., Masuda, K., Nguyen, H. T. N., Pham, T. T. M., Han, X., Hirofuji, Y. & Nonaka, K., Jan 1 2017, In : BioMed Research International. 2017, 6037159.

Research output: Contribution to journalArticle

Chromosomes, Human, Pair 21
Human Chromosomes
Chromosomes
Cells
Trisomy
8 Citations (Scopus)

Mitochondria regulate the differentiation of stem cells from human exfoliated deciduous teeth

Kato, H., Pham, T. T. M., Yamaza, H., Masuda, K., Hirofuji, Y., Han, X., Sato, H., Taguchi, T. & Nonaka, K., Jan 1 2017, In : Cell structure and function. 42, 2, p. 105-116 12 p.

Research output: Contribution to journalArticle

Carbonyl Cyanide m-Chlorophenyl Hydrazone
Rotenone
Deciduous Tooth
Mitochondria
Stem Cells
2016
8 Citations (Scopus)

Dihydroorotate dehydrogenase depletion hampers mitochondrial function and osteogenic differentiation in osteoblasts

Fang, J., Yamaza, H., Uchiumi, T., Hoshino, Y., Masuda, K., Hirofuji, Y., Wagener, F. A. D. T. G., Kang, D. & Nonaka, K., Jun 1 2016, In : European Journal of Oral Sciences. 124, 3, p. 241-245 5 p.

Research output: Contribution to journalArticle

Osteoblasts
Small Interfering RNA
Adenosine Triphosphate
Cell Proliferation
dihydroorotate dehydrogenase
12 Citations (Scopus)

Interferon-gamma improves impaired dentinogenic and immunosuppressive functions of irreversible pulpitis-derived human dental pulp stem cells

Sonoda, S., Yamaza, H., Ma, L., Tanaka, Y., Tomoda, E., Aijima, R., Nonaka, K., Kukita, T., Shi, S., Nishimura, F. & Yamaza, T., Jan 18 2016, In : Scientific reports. 6, 19286.

Research output: Contribution to journalArticle

Pulpitis
Dental Pulp
Immunosuppressive Agents
Interferon-gamma
Stem Cells
2015
4 Citations (Scopus)
Mixed Dentition
Odontogenic Tumors
Bicuspid
Tooth Germ
Tooth
22 Citations (Scopus)

In vivo hepatogenic capacity and therapeutic potential of stem cells from human exfoliated deciduous teeth in liver fibrosis in mice

Yamaza, T., Alatas, F. S., Yuniartha, R., Yamaza, H., Fujiyoshi, J. K., Yanagi, Y., Yoshimaru, K., Hayashida, M., Matsuura, T., Aijima, R., Ihara, K., Ohga, S., Shi, S., Nonaka, K. & Taguchi, T., Sep 10 2015, In : Stem Cell Research and Therapy. 6, 1, 171.

Research output: Contribution to journalArticle

Deciduous Tooth
Stem cells
Liver Cirrhosis
Liver
Stem Cells

Overexpression of the adiponectin gene mimics the metabolic and stress resistance effects of calorie restriction, but not the anti-tumor effect

Kamohara, R., Yamaza, H., Tsuchiya, T., Komatsu, T., Park, S., Hayashi, H., Chiba, T., Mori, R., Otabe, S., Yamada, K., Nagayasu, T. & Shimokawa, I., Apr 1 2015, In : Experimental Gerontology. 64, p. 46-54 9 p.

Research output: Contribution to journalArticle

Physiological Stress
Adiponectin
Nutrition
Tumors
Genes
33 Citations (Scopus)

The life-extending effect of dietary restriction requires Foxo3 in mice

Shimokawa, I., Komatsu, T., Hayashi, N., Kim, S. E., Kawata, T., Park, S., Hayashi, H., Yamaza, H., Chiba, T. & Mori, R., Aug 1 2015, In : Aging cell. 14, 4, p. 707-709 3 p.

Research output: Contribution to journalArticle

Neoplasms
Forkhead Transcription Factors
23 Citations (Scopus)

Transplantation of mesenchymal stem cells ameliorates secondary osteoporosis through interleukin-17-impaired functions of recipient bone marrow mesenchymal stem cells in MRL/lpr mice

Ma, L., Aijima, R., Hoshino, Y., Yamaza, H., Tomoda, E., Tanaka, Y., Sonoda, S., Song, G., Zhao, W., Nonaka, K., Shi, S. & Yamaza, T., May 27 2015, In : Stem Cell Research and Therapy. 6, 1, 104.

Research output: Contribution to journalArticle

Inbred MRL lpr Mouse
Mesenchymal Stem Cell Transplantation
Interleukin-17
Stem cells
Mesenchymal Stromal Cells
2014
1 Citation (Scopus)

Clinical approach to a suspected case of first branchial arch syndrome

Yamaguchi, N., Nakamura, S., Yamaza, H., Nishigaki, S., Masuda, K., Yanagita, K. I. & Nonaka, K., Jan 1 2014, In : Case Reports in Medicine. 2014, 506804.

Research output: Contribution to journalArticle

Branchial Region
Cephalometry
Ear
Hearing Loss
Goldenhar Syndrome
2013
29 Citations (Scopus)

Dihydro-orotate dehydrogenase is physically associated with the respiratory complex and its loss leads to mitochondrial dysfunction

Fang, J. X., Uchiumi, T., Yagi, M., Matsumoto, S., Amamoto, R., Takazaki, S., Yamaza, H., Nonaka, K. & Kang, D., May 20 2013, In : Bioscience reports. 33, 2, p. 217-227 11 p., e00021.

Research output: Contribution to journalArticle

Electron Transport
Biosynthesis
G2 Phase Cell Cycle Checkpoints
Native Polyacrylamide Gel Electrophoresis
dihydroorotate dehydrogenase

Dihydro-orotate dehydrogenase is physically associated with the respiratory complex and its loss leads to mitochondrial dysfunction.

Fang, J. X., Uchiumi, T., Yagi, M., Matsumoto, S., Amamoto, R., Takazaki, S., Yamaza, H., Nonaka, K. & Kang, D., 2013, In : Bioscience Reports. 33, 2

Research output: Contribution to journalArticle

Electron Transport
Biosynthesis
G2 Phase Cell Cycle Checkpoints
Native Polyacrylamide Gel Electrophoresis
dihydroorotate dehydrogenase
22 Citations (Scopus)

Immune therapeutic potential of stem cells from human supernumerary teeth

Makino, Y., Yamaza, H., Akiyama, K., Ma, L., Hoshino, Y., Nonaka, K., Terada, Y., Kukita, T., Shi, S. & Yamaza, T., Jul 1 2013, In : Journal of Dental Research. 92, 7, p. 609-615 7 p.

Research output: Contribution to journalArticle

Supernumerary Tooth
Inbred MRL lpr Mouse
Stem Cells
Th17 Cells
Stem Cell Transplantation
12 Citations (Scopus)

Multiple functional involvement of Thymosin beta-4 in tooth germ development

Ookuma, Y. F., Kiyoshima, T., Kobayashi, I., Nagata, K., Wada, H., Fujiwara, H., Yamaza, H., Nonaka, K. & Sakai, H., Feb 1 2013, In : Histochemistry and Cell Biology. 139, 2, p. 355-370 16 p.

Research output: Contribution to journalArticle

Tooth Germ
Mandible
Oligodeoxyribonucleotides
Epithelial Cells
Sulfur
2012
57 Citations (Scopus)

Cryopreserved Dental Pulp Tissues of Exfoliated Deciduous Teeth Is a Feasible Stem Cell Resource for Regenerative Medicine

Ma, L., Makino, Y., Yamaza, H., Akiyama, K., Hoshino, Y., Song, G., Kukita, T., Nonaka, K., Shi, S. & Yamaza, T., Dec 14 2012, In : PloS one. 7, 12, e51777.

Research output: Contribution to journalArticle

tooth pulp
Dental Pulp
Regenerative Medicine
Deciduous Tooth
Stem cells
17 Citations (Scopus)

Protein instability and functional defects caused by mutations of dihydro-orotate dehydrogenase in Miller syndrome patients

Fang, J. X., Uchiumi, T., Yagi, M., Matsumoto, S., Amamoto, R., Saito, T., Takazaki, S., Kanki, T., Yamaza, H., Nonaka, K. & Kang, D., Dec 1 2012, In : Bioscience reports. 32, 6, p. 631-639 9 p.

Research output: Contribution to journalArticle

Defects
Mutation
Protein Stability
Proteins
Mitochondria
2011
1 Citation (Scopus)

Down-regulation of hepatic AMP-activated protein kinase and up-regulation of CREB coactivator CRTC2 for gluconeogenesis under calorie-restricted conditions at a young age

Trindade, L. S., Park, S. J., Komatsu, T., Yamaza, H., Hayashi, H., Mori, R., Chiba, T., Shimokawa, I. & Kuramoto, K., Jan 1 2011, In : Acta Medica Nagasakiensia. 55, 2, p. 85-92 8 p.

Research output: Contribution to journalArticle

AMP-Activated Protein Kinases
Gluconeogenesis
Up-Regulation
Down-Regulation
Sirolimus
2 Citations (Scopus)

Effect of insulin-like growth factors on lung development in a nitrofen-induced CDH rat model

Esumi, G., Masumoto, K., Teshiba, R., Nagata, K., Kinoshita, Y., Yamaza, H., Nonaka, K. & Taguchi, T., Feb 1 2011, In : Pediatric surgery international. 27, 2, p. 187-192 6 p.

Research output: Contribution to journalArticle

Somatomedins
Lung
Fetus
Congenital Diaphragmatic Hernias
nitrofen
2010
46 Citations (Scopus)

FoxO1 is involved in the antineoplastic effect of calorie restriction

Yamaza, H., Komatsu, T., Wakita, S., Kijogi, C., Park, S., Hayashi, H., Chiba, T., Mori, R., Furuyama, T., Mori, N. & Shimokawa, I., Jun 1 2010, In : Aging cell. 9, 3, p. 372-382 11 p.

Research output: Contribution to journalArticle

Antineoplastic Agents
Oxidative Stress
Genes
Body Weight Changes
Liver
12 Citations (Scopus)

Protogenin, a new member of the immunoglobulin superfamily, is implicated in the development of the mouse lower first molar

Takahashi, K. F., Kiyoshima, T., Kobayashi, I., Xie, M., Yamaza, H., Fujiwara, H., Ookuma, Y., Nagata, K., Wada, H., Sakai, T., Terada, Y. & Sakai, H., Nov 29 2010, In : BMC Developmental Biology. 10, 115.

Research output: Contribution to journalArticle

Tooth Germ
Mandible
Immunoglobulins
Epithelial Cells
Oligodeoxyribonucleotides
29 Citations (Scopus)

SIRT1 regulates thyroid-stimulating hormone release by enhancing PIP5Kγ activity through deacetylation of specific lysine residues in mammals

Akieda-Asai, S., Zaima, N., Ikegami, K., Kahyo, T., Yao, I., Hatanaka, T., Iemura, S. I., Sugiyama, R., Yokozeki, T., Eishi, Y., Koike, M., Ikeda, K., Chiba, T., Yamaza, H., Shimokawa, I., Song, S. Y., Matsuno, A., Mizutani, A., Sawabe, M., Chao, M. V. & 8 others, Tanaka, M., Kanaho, Y., Natsume, T., Sugimura, H., Date, Y., Mcburney, M. W., Guarente, L. & Setou, M., Aug 16 2010, In : PloS one. 5, 7, e11755.

Research output: Contribution to journalArticle

thyrotropin
Mammals
phosphatidylinositols
Thyrotropin
Metabolism
2009
1 Citation (Scopus)

A transgenic dwarf rat strain as a tool for the study of immunosenescence in aging rats and the effect of calorie restriction

Shimokawa, I., Utsuyama, M., Komatsu, T., Yamaza, H. & Chiba, T., Jan 1 2009, Handbook on Immunosenescence: Basic Understanding and Clinical Applications. Springer Netherlands, p. 131-144 14 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Transgenic Rats
Growth Hormone
Immune System
Lymphocyte Subsets
Laboratory Animals
4 Citations (Scopus)

Divergent regulation of adipose tissue metabolism by calorie restriction and inhibition of growth hormone signaling

Park, S., Komatsu, T., Hayashi, H., Trindade, L. S., Yamaza, H., Chiba, T. & Shimokawa, I., Oct 1 2009, In : Experimental Gerontology. 44, 10, p. 646-652 7 p.

Research output: Contribution to journalArticle

Enzyme inhibition
Metabolism
Growth Hormone
Adipose Tissue
Rats
14 Citations (Scopus)

Identification and characterization of an insulin receptor substrate 4-interacting protein in rat brain: Implications for longevity

Chiba, T., Inoue, D., Mizuno, A., Komatsu, T., Fujita, S., Kubota, H., Luisa Tagliaro, M., Park, S., Trindade, L. S., Hayashida, T., Hayashi, H., Yamaza, H., Higami, Y. & Shimokawa, I., Mar 1 2009, In : Neurobiology of Aging. 30, 3, p. 474-482 9 p.

Research output: Contribution to journalArticle

Insulin Receptor Substrate Proteins
Hypothalamus
Brain
Insulin-Like Growth Factor I
Insulin
22 Citations (Scopus)

Similar metabolic responses to calorie restriction in lean and obese Zucker rats

Chiba, T., Komatsu, T., Nakayama, M., Adachi, T., Tamashiro, Y., Hayashi, H., Yamaza, H., Higami, Y. & Shimokawa, I., Oct 15 2009, In : Molecular and Cellular Endocrinology. 309, 1-2, p. 17-25 9 p.

Research output: Contribution to journalArticle

Zucker Rats
Rats
Insulin
Neuropeptide Y
Insulin Resistance
2008
10 Citations (Scopus)

Calorie restriction initiated at a young age activates the Akt/PKCζ/λ-Glut4 pathway in rat white adipose tissue in an insulin-independent manner

Park, S., Komatsu, T., Hayashi, H., Yamaza, H., Chiba, T., Higami, Y., Kuramoto, K. & Shimokawa, I., Dec 1 2008, In : Age. 30, 4, p. 293-302 10 p.

Research output: Contribution to journalArticle

White Adipose Tissue
Protein Kinase C
Insulin
Glucose
Facilitative Glucose Transport Proteins
12 Citations (Scopus)

Calorie restriction minimizes activation of insulin signaling in response to glucose: Potential involvement of the growth hormone-insulin-like growth factor 1 axis

Hayashi, H., Yamaza, H., Komatsu, T., Park, S., Chiba, T., Higami, Y., Nagayasu, T. & Shimokawa, I., Sep 1 2008, In : Experimental Gerontology. 43, 9, p. 827-832 6 p.

Research output: Contribution to journalArticle

Quadriceps Muscle
Somatomedins
Growth Hormone
Rats
Chemical activation
14 Citations (Scopus)

Glycolytic enzyme Pgk1 is strongly expressed in the developing tooth germ of the mouse lower first molar

Honda, J. Y., Kobayashi, I., Kiyoshima, T., Yamaza, H., Xie, M., Takahashi, K., Enoki, N., Nagata, K., Nakashima, A. & Sakai, H., Apr 2008, In : Histology and Histopathology. 23, 4, p. 423-432 10 p.

Research output: Contribution to journalArticle

Tooth Germ
Phosphoglycerate Kinase
Glyceraldehyde-3-Phosphate Dehydrogenases
Enzymes
Fluorescent Antibody Technique
34 Citations (Scopus)

Longevity genes: Insights from calorie restriction and genetic longevity models

Shimokawa, I., Chiba, T., Yamaza, H. & Komatsu, T., Nov 30 2008, In : Molecules and cells. 26, 5, p. 427-435 9 p.

Research output: Contribution to journalShort survey

Genetic Models
Genes
Somatomedins
Food
Growth Hormone
42 Citations (Scopus)

Manipulation of caloric content but not diet composition, attenuates the deficit in learning and memory of senescence-accelerated mouse strain P8

Komatsu, T., Chiba, T., Yamaza, H., Yamashita, K., Shimada, A., Hoshiyama, Y., Henmi, T., Ohtani, H., Higami, Y., de Cabo, R., Ingram, D. K. & Shimokawa, I., Apr 1 2008, In : Experimental Gerontology. 43, 4, p. 339-346 8 p.

Research output: Contribution to journalArticle

Nutrition
Learning
Diet
Data storage equipment
Chemical analysis
21 Citations (Scopus)

Pituitary growth hormone suppression reduces resistin expression and enhances insulin effectiveness: Relationship with caloric restriction

Chiba, T., Yamaza, H., Komatsu, T., Nakayama, M., Fujita, S., Hayashi, H., Higami, Y. & Shimokawa, I., Jun 1 2008, In : Experimental Gerontology. 43, 6, p. 595-600 6 p.

Research output: Contribution to journalArticle

Resistin
Caloric Restriction
Growth Hormone
Insulin
Insulin-Like Growth Factor I
2007
32 Citations (Scopus)

Down-regulation of AMP-activated protein kinase by calorie restriction in rat liver

To, K., Yamaza, H., Komatsu, T., Hayashida, T., Hayashi, H., Toyama, H., Chiba, T., Higami, Y. & Shimokawa, I., Nov 1 2007, In : Experimental Gerontology. 42, 11, p. 1063-1071 9 p.

Research output: Contribution to journalArticle

AMP-Activated Protein Kinases
Liver
Rats
Down-Regulation
Quadriceps Muscle
16 Citations (Scopus)

Functional implication of nucleolin in the mouse first molar development

Xie, M., Kobayashi, I., Kiyoshima, T., Yamaza, H., Honda, J. Y., Takahashi, K., Enoki, N., Akamine, A. & Sakai, H., Aug 10 2007, In : Journal of Biological Chemistry. 282, 32, p. 23275-23283 9 p.

Research output: Contribution to journalArticle

Enamels
Tooth Germ
Dental Enamel
Mandible
Messenger RNA
7 Citations (Scopus)

Identification of fasting-induced genes in the rat hypothalamus: Relationship with neuroprotection

Chiba, T., Fujita, S., Kubota, H., Inoue, D., Mizuno, A., Komatsu, T., Yamaza, H., Higami, Y. & Shimokawa, I., Jan 1 2007, In : Annals of the New York Academy of Sciences. 1119, 1, p. 216-226 11 p.

Research output: Contribution to journalArticle

Hypothalamus
Rats
Fasting
Cell Death
Genes