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Research Output 2005 2019

  • 2588 Citations
  • 28 h-Index
  • 50 Article
  • 10 Review article
  • 3 Chapter
  • 1 Letter
2019

Evidence for detection of rat P2X4 receptor expressed on cells by generating monoclonal antibodies recognizing the native structure

Igawa, T., Kishikawa, S., Abe, Y., Yamashita, T., Nagai, S., Shiroishi, M., Shinozaki, C., Tanaka, H., Saitoh, H., Makoto, T., Inoue, K. & Ueda, T., Jan 1 2019, (Accepted/In press) In : Purinergic Signalling.

Research output: Contribution to journalArticle

Purinergic P2X4 Receptors
Monoclonal Antibodies
Antibodies
Purinergic P2X Receptors
Head
1 Citation (Scopus)

Transcription factor MafB contributes to the activation of spinal microglia underlying neuropathic pain development

Saitoh, H., Masuda, J., Kawada, R., Kojima, C., Yoneda, S., Masuda, T., Inoue, K. & Makoto, T., Apr 1 2019, In : GLIA. 67, 4, p. 729-740 12 p.

Research output: Contribution to journalArticle

MafB Transcription Factor
Peripheral Nerve Injuries
Microglia
Neuralgia
Hypersensitivity
2018
3 Citations (Scopus)

Astrocytic Ca2+ responses in the spinal dorsal horn by noxious stimuli to the skin

Yoshihara, K., Matsuda, T., Koro, Y., Saitoh, H., Inoue, K. & Makoto, T., May 1 2018, In : Journal of Pharmacological Sciences. 137, 1, p. 101-104 4 p.

Research output: Contribution to journalArticle

Astrocytes
Skin
Automatic Data Processing
Photons
Formaldehyde

Green Pharma: A new strategy for drug discovery in academia by targeting glial cells and ATP receptors

Yamashita, T., Makoto, T., Saitoh, H. & Inoue, K., Jan 1 2018, In : Yakugaku Zasshi. 138, 8, p. 1027-1031 5 p.

Research output: Contribution to journalReview article

Purinergic P2 Receptors
Drug Discovery
Neuroglia
Hyperalgesia
Neuralgia
oxaliplatin
Hyperalgesia
Pharmacology
Small Molecule Libraries
Peripheral Nervous System Diseases
5 Citations (Scopus)

Optogenetic activation of non-nociceptive aβ fibers induces neuropathic pain-like sensory and emotional behaviors after nerve injury in rats

Tashima, R., Koga, K., Sekine, M., Kanehisa, K., Koro, Y., Tominaga, K., Matsushita, K., Saitoh, H., Fukazawa, Y., Inoue, K., Yawo, H., Furue, H. & Makoto, T., Jan 1 2018, In : eNeuro. 5, 1, e0450-17.2018.

Research output: Contribution to journalArticle

Optogenetics
Peripheral Nerve Injuries
Neuralgia
Myelinated Nerve Fibers
Wounds and Injuries
3 Citations (Scopus)

Temporal kinetics of microgliosis in the spinal dorsal horn after peripheral nerve injury in rodents

Kohno, K., Kitano, J., Koro, Y., Saitoh, H., Inoue, K. & Makoto, T., Jan 1 2018, In : Biological and Pharmaceutical Bulletin. 41, 7, p. 1096-1102 7 p.

Research output: Contribution to journalArticle

Peripheral Nerve Injuries
Rodentia
Microglia
Neuralgia
S Phase
13 Citations (Scopus)

Top-down descending facilitation of spinal sensory excitatory transmission from the anterior cingulate cortex

Chen, T., Taniguchi, W., Chen, Q. Y., Saitoh, H., Song, Q., Liu, R. H., Koga, K., Matsuda, T., Kaito-Sugimura, Y., Wang, J., Li, Z. H., Lu, Y. C., Inoue, K., Makoto, T., Li, Y. Q., Nakatsuka, T. & Zhuo, M., Dec 1 2018, In : Nature communications. 9, 1, 1886.

Research output: Contribution to journalArticle

cortexes
Gyrus Cinguli
pain
Modulation
Synaptic Transmission
2017
3 Citations (Scopus)
NFATC Transcription Factors
Cell signaling
CC Chemokines
Microglia
Adenosine Diphosphate
Interneurons
Spinal Cord Dorsal Horn
2016
28 Citations (Scopus)

A novel P2X4 receptor-selective antagonist produces anti-allodynic effect in a mouse model of herpetic pain

Matsumura, Y., Yamashita, T., Sasaki, A., Nakata, E., Kohno, K., Masuda, T., Saitoh, H., Imai, T., Kuraishi, Y., Makoto, T. & Inoue, K., Aug 31 2016, In : Scientific reports. 6, 32461.

Research output: Contribution to journalArticle

Purinergic P2X4 Receptors
Chronic Pain
Acute Pain
Pain
Down-Regulation
16 Citations (Scopus)

Bone marrow-derived cells in the population of spinal microglia after peripheral nerve injury

Tashima, R., Mikuriya, S., Tomiyama, D., Shiratori, M., Yamashita, T., Koro, Y., Saitoh, H., Inoue, K. & Makoto, T., Mar 23 2016, In : Scientific reports. 6, 23701.

Research output: Contribution to journalArticle

Peripheral Nerve Injuries
Microglia
Bone Marrow Cells
Population
Spinal Cord
40 Citations (Scopus)

Dorsal horn neurons release extracellular ATP in a VNUT-dependent manner that underlies neuropathic pain

Masuda, T., Ozono, Y., Mikuriya, S., Koro, Y., Saitoh, H., Iwatsuki, K., Uneyama, H., Ichikawa, R., Salter, M. W., Makoto, T. & Inoue, K., Aug 12 2016, In : Nature communications. 7, 12529.

Research output: Contribution to journalArticle

Posterior Horn Cells
transporter
pain
adenosine triphosphate
nucleotides
15 Citations (Scopus)

Duloxetine inhibits microglial P2X4 receptor function and alleviates neuropathic pain after peripheral nerve injury

Yamashita, T., Yamamoto, S., Zhang, J., Kometani, M., Tomiyama, D., Kohno, K., Saitoh, H., Inoue, K. & Makoto, T., Oct 1 2016, In : PloS one. 11, 10, e0165189.

Research output: Contribution to journalArticle

Purinergic P2X4 Receptors
Peripheral Nerve Injuries
peripheral nerves
Neuralgia
pain
26 Citations (Scopus)

Purinergic P2Y6 receptors heterodimerize with angiotensin AT1 receptors to promote angiotensin II-induced hypertension

Nishimura, A., Sunggip, C., Saitoh, H., Shimauchi, T., Numaga-Tomita, T., Hirano, K., Ide, T., Boeynaems, J. M., Kurose, H., Makoto, T., Robaye, B., Inoue, K. & Nishida, M., Jan 19 2016, In : Science Signaling. 9, 411, aac9187.

Research output: Contribution to journalArticle

Purinergic Receptors
Angiotensin Type 1 Receptor
Angiotensin II
Hypertension
Arrestin
2015
24 Citations (Scopus)

A new minimally-invasive method for microinjection into the mouse spinal dorsal horn

Koro, Y., Sakaguchi, E., Tashima, R., Saitoh, H., Okano, H., Inoue, K. & Makoto, T., Sep 21 2015, In : Scientific reports. 5, 14306.

Research output: Contribution to journalArticle

Microinjections
Laminectomy
Inflammation
Gene Expression
Peripheral Nerve Injuries
50 Citations (Scopus)

STAT3-dependent reactive astrogliosis in the spinal dorsal horn underlies chronic itch

Shiratori, M., Koga, K., Saitoh, H., Koro, Y., Toyonaga, H., Yamaguchi, C., Hasegawa, A., Nakahara, T., Hachisuka, J., Akira, S., Okano, H., Furue, M., Inoue, K. & Makoto, T., Aug 8 2015, In : Nature medicine. 21, 8, p. 927-931 5 p.

Research output: Contribution to journalArticle

STAT3 Transcription Factor
Lipocalins
Atopic Dermatitis
Dermatitis
Gastrin-Releasing Peptide
20 Citations (Scopus)

Transcription factor IRF1 is responsible for IRF8-mediated IL-1β expression in reactive microglia

Masuda, T., Iwamoto, S., Mikuriya, S., Saitoh, H., Tamura, T., Makoto, T. & Inoue, K., Sep 4 2015, In : Journal of Pharmacological Sciences. 128, 4, p. 216-220 5 p.

Research output: Contribution to journalArticle

Microglia
Interleukin-1
Transcription Factors
Gene Expression
Up-Regulation
2014
17 Citations (Scopus)

Acute hyperglycemia impairs functional improvement after spinal cord injury in mice and humans

Kobayakawa, K., Kumamaru, H., Saiwai, H., Kubota, K., Ohkawa, Y., Kishimoto, J., Yokota, K., Ideta, R., Shiba, K., Saitoh, H., Inoue, K., Iwamoto, Y. & Okada, S., Jan 1 2014, In : Science Translational Medicine. 6, 256, 256ra137.

Research output: Contribution to journalArticle

Spinal Cord Injuries
Hyperglycemia
Obese Mice
Nervous System Trauma
Blood Glucose
35 Citations (Scopus)

Chemokine (C-C motif) receptor 5 Is an important pathological regulator in the development and maintenance of neuropathic pain

Matsushita, K., Saitoh, H., Kojima, C., Masuda, T., Makoto, T., Inoue, K. & Hoka, S., Jan 1 2014, In : Anesthesiology. 120, 6, p. 1491-1503 13 p.

Research output: Contribution to journalArticle

CCR Receptors
Neuralgia
Hyperalgesia
Chemokine CCL3
Maintenance
9 Citations (Scopus)

Interferon regulatory factor 8 expressed in microglia contributes to tactile allodynia induced by repeated cold stress in rodents

Akagi, T., Matsumura, Y., Yasui, M., Minami, E., Inoue, H., Masuda, T., Saitoh, H., Tamura, T., Mizumura, K., Makoto, T., Kiyama, H. & Inoue, K., Jan 1 2014, In : Journal of Pharmacological Sciences. 126, 2, p. 172-176 5 p.

Research output: Contribution to journalArticle

Hyperalgesia
Microglia
Rodentia
interferon regulatory factor-8
Knockout Mice
26 Citations (Scopus)

Involvement of the chemokine CCL3 and the purinoceptor P2X7 in the spinal cord in paclitaxel-induced mechanical allodynia

Ochi-ishi, R., Nagata, K., Inoue, T., Saitoh, H., Makoto, T. & Inoue, K., Aug 15 2014, In : Molecular Pain. 10, 1, 53.

Research output: Contribution to journalArticle

Purinergic P2X7 Receptors
CC Chemokines
Hyperalgesia
Paclitaxel
Chemokines
11 Citations (Scopus)

IRF8 is a transcriptional determinant for microglial motility

Masuda, T., Nishimoto, N., Tomiyama, D., Matsuda, T., Saitoh, H., Tamura, T., Kohsaka, S., Makoto, T. & Inoue, K., Jan 1 2014, In : Purinergic Signalling. 10, 3, p. 515-521 7 p.

Research output: Contribution to journalArticle

Microglia
Chemotaxis
Adenosine Triphosphate
Complement C5a
interferon regulatory factor-8

Spinal cord is the primary site of action of the cannabinoid CB2 receptor agonist JWH133 that suppresses neuropathic pain: Possible involvement of microglia

Shimoyama, H., Makoto, T., Masuda, T., Yoshinaga, R., Tsukamoto, K., Saitoh, H. & Inoue, K., Jan 1 2014, In : Open Pain Journal. 7, 1

Research output: Contribution to journalArticle

Cannabinoid Receptor Agonists
Microglia
Neuralgia
Cannabinoid Receptor CB2
Spinal Cord
73 Citations (Scopus)

Transcription factor IRF5 drives P2X4R+-reactive microglia gating neuropathic pain

Masuda, T., Iwamoto, S., Yoshinaga, R., Saitoh, H., Nishiyama, A., Mak, T. W., Tamura, T., Makoto, T. & Inoue, K., May 13 2014, In : Nature Communications. 5, 3771.

Research output: Contribution to journalArticle

Purinergic P2X4 Receptors
Interferon Regulatory Factors
interferon
pain
Microglia
2013
1 Citation (Scopus)

Intrathecal infusion of microglia cells

Masuda, T., Makoto, T., Saitoh, H. & Inoue, K., Jul 18 2013, Microglia: Methods and Protocols. p. 291-294 4 p. (Methods in Molecular Biology; vol. 1041).

Research output: Chapter in Book/Report/Conference proceedingChapter

Microglia
Peripheral Nerve Injuries
Subarachnoid Space
Neuralgia
Cultured Cells
4 Citations (Scopus)

Lentiviral transduction of cultured microglia

Masuda, T., Makoto, T., Saitoh, H. & Inoue, K., 2013, Microglia: Methods and Protocols. Vol. 1041. p. 63-67 5 p. (Methods in Molecular Biology; vol. 1041).

Research output: Chapter in Book/Report/Conference proceedingChapter

Gene Transfer Techniques
Microglia
Neuroglia
Nervous System
Cultured Cells
75 Citations (Scopus)

Microglial regulation of neuropathic pain

Makoto, T., Masuda, T., Saitoh, H. & Inoue, K., Feb 26 2013, In : Journal of Pharmacological Sciences. 121, 2, p. 89-94 6 p.

Research output: Contribution to journalReview article

Neuralgia
Microglia
Wounds and Injuries
Posterior Horn Cells
Gene Expression
58 Citations (Scopus)

P2X4 receptors and neuropathic pain

Makoto, T., Masuda, T., Saitoh, H. & Inoue, K., Oct 28 2013, In : Frontiers in Cellular Neuroscience. OCT, 191.

Research output: Contribution to journalReview article

Purinergic P2X4 Receptors
Microglia
Neuralgia
Chemokine CCL21
CCR Receptors
43 Citations (Scopus)

The intrinsic microglial molecular clock controls synaptic strength via the circadian expression of cathepsin S

Hayashi, Y., Satoru, K., Kusunose, N., Okada, R., Take, H., Saitoh, H., Ukai, K., Kohsaka, S., Inoue, K., Ohdo, S. & Nakanishi, H., Oct 14 2013, In : Scientific reports. 3, 2744.

Research output: Contribution to journalArticle

cathepsin S
Microglia
Cats
Neurons
Spine
2012
52 Citations (Scopus)

CCL2 promotes P2X4 receptor trafficking to the cell surface of microglia

Toyomitsu, E., Makoto, T., Yamashita, T., Saitoh, H., Tanaka, Y. & Inoue, K., Jun 1 2012, In : Purinergic Signalling. 8, 2, p. 301-310 10 p.

Research output: Contribution to journalArticle

Purinergic P2X4 Receptors
Microglia
Lysosomes
Exocytosis
Green Fluorescent Proteins
11 Citations (Scopus)

Involvement of protein kinase D in uridine diphosphate-induced microglial macropinocytosis and phagocytosis

Uesugi, A., Kataoka, A., Saitoh, H., Koga, Y., Makoto, T., Robaye, B., Boeynaems, J. M. & Inoue, K., Jul 1 2012, In : GLIA. 60, 7, p. 1094-1105 12 p.

Research output: Contribution to journalArticle

Uridine Diphosphate
Phagocytosis
Microglia
Microspheres
Vacuoles
123 Citations (Scopus)

IRF8 Is a Critical Transcription Factor for Transforming Microglia into a Reactive Phenotype

Masuda, T., Makoto, T., Yoshinaga, R., Saitoh, H., Ozato, K., Tamura, T. & Inoue, K., Mar 19 2012, In : Cell Reports. 1, 4, p. 334-340 7 p.

Research output: Contribution to journalArticle

Microglia
Transcription Factors
Phenotype
Peripheral Nerve Injuries
Gene expression
4 Citations (Scopus)

P2X4R and P2X7R in neuropathic pain

Makoto, T., Saitoh, H. & Inoue, K., Jul 1 2012, In : Wiley Interdisciplinary Reviews: Membrane Transport and Signaling. 1, 4, p. 513-521 9 p.

Research output: Contribution to journalArticle

Neuralgia
Purinergic Receptors
Microglia
Purinergic P2 Receptors
Posterior Horn Cells
7 Citations (Scopus)

P2Y receptors in microglia and neuroinflammation

Saitoh, H., Makoto, T. & Inoue, K., Jul 1 2012, In : Wiley Interdisciplinary Reviews: Membrane Transport and Signaling. 1, 4, p. 493-501 9 p.

Research output: Contribution to journalReview article

Microglia
Central Nervous System
Purinergic Receptors
Cytophagocytosis
Uridine Diphosphate
39 Citations (Scopus)

Purinergic system, microglia and neuropathic pain

Makoto, T., Saitoh, H. & Inoue, K., Feb 1 2012, In : Current Opinion in Pharmacology. 12, 1, p. 74-79 6 p.

Research output: Contribution to journalReview article

Microglia
Neuralgia
Purinergic Receptors
Peripheral Nerve Injuries
Neuroglia
8 Citations (Scopus)

Role of the glia in neuropathic pain caused by peripheral nerve injury

Inoue, K., Makoto, T. & Saitoh, H., Nov 2012, In : Brain and Nerve. 64, 11, p. 1233-1239 7 p.

Research output: Contribution to journalReview article

Peripheral Nerve Injuries
Neuralgia
Neuroglia
Microglia
Astrocytes
2011
54 Citations (Scopus)
Purinergic P2Y1 Receptors
Middle Cerebral Artery Infarction
Brain Ischemia
Chemokines
Chemokine CXCL10
4 Citations (Scopus)

Involvement of vasodilator-stimulated phosphoprotein in UDP-induced microglial actin aggregation via PKC- and Rho-dependent pathways

Kataoka, A., Koga, Y., Uesugi, A., Saitoh, H., Makoto, T. & Inoue, K., Dec 1 2011, In : Purinergic Signalling. 7, 4, p. 403-411 9 p.

Research output: Contribution to journalArticle

Uridine Diphosphate
Actins
Microglia
Phosphorylation
Microfilament Proteins
136 Citations (Scopus)

JAK-STAT3 pathway regulates spinal astrocyte proliferation and neuropathic pain maintenance in rats

Makoto, T., Koro, Y., Yano, T., Tsujikawa, T., Kitano, J., Saitoh, H., Satoru, K., Ohdo, S., Ji, R. R., Salter, M. W. & Inoue, K., Apr 1 2011, In : Brain. 134, 4, p. 1127-1139 13 p.

Research output: Contribution to journalArticle

Neuralgia
STAT3 Transcription Factor
Astrocytes
Maintenance
Janus Kinases
95 Citations (Scopus)

Neuronal CCL21 up-regulates microglia P2X4 expression and initiates neuropathic pain development

Biber, K., Makoto, T., Saitoh, H., Tsukamoto, K., Toyomitsu, E., Masuda, T., Boddeke, H. & Inoue, K., May 4 2011, In : EMBO Journal. 30, 9, p. 1864-1873 10 p.

Research output: Contribution to journalArticle

Purinergic P2X4 Receptors
Hyperalgesia
Microglia
Neuralgia
Up-Regulation
13 Citations (Scopus)

Platelet-activating factor and pain

Makoto, T., Saitoh, H. & Inoue, K., Aug 1 2011, In : Biological and Pharmaceutical Bulletin. 34, 8, p. 1159-1162 4 p.

Research output: Contribution to journalReview article

Platelet Activating Factor
Pain
Neuralgia
Spinal Ganglia
Wounds and Injuries
28 Citations (Scopus)

Reduced spinal microglial activation and neuropathic pain after nerve injury in mice lacking all three nitric oxide synthases

Kuboyama, K., Makoto, T., Tsutsui, M., Toyohara, Y., Saitoh, H., Shimokawa, H., Yanagihara, N. & Inoue, K., Jul 14 2011, In : Molecular Pain. 7, 50.

Research output: Contribution to journalArticle

Neuralgia
Nitric Oxide Synthase
Hyperalgesia
Wounds and Injuries
Pain
18 Citations (Scopus)

Role of Purinergic Receptors in CNS Function and Neuroprotection

Saitoh, H., Makoto, T. & Inoue, K., Jan 1 2011, In : Advances in Pharmacology. 61, p. 495-528 34 p.

Research output: Contribution to journalArticle

Purinergic Receptors
Microglia
Central Nervous System
Neuroglia
Oligodendroglia
2010
48 Citations (Scopus)

Nerve injury-activated microglia engulf myelinated axons in a P2Y12 signaling-dependent manner in the dorsal horn

Maeda, M., Makoto, T., Saitoh, H., Inoue, K. & Kiyama, H., Nov 15 2010, In : GLIA. 58, 15, p. 1838-1846 9 p.

Research output: Contribution to journalArticle

Microglia
Axons
Wounds and Injuries
Neuralgia
Purinergic P2 Receptors
79 Citations (Scopus)

P2X7 receptor activation induces CXCL2 production in microglia through NFAT and PKC/MAPK pathways

Shiratori, M., Saitoh, H., Yoshitake, M., Makoto, T. & Inoue, K., Jan 1 2010, In : Journal of Neurochemistry. 114, 3, p. 810-819 10 p.

Research output: Contribution to journalArticle

Purinergic P2X7 Receptors
NFATC Transcription Factors
Microglia
Adenosine Triphosphate
Chemical activation
90 Citations (Scopus)

Pain and purinergic signaling

Makoto, T., Saitoh, H. & Inoue, K., May 1 2010, In : Brain Research Reviews. 63, 1-2, p. 222-232 11 p.

Research output: Contribution to journalReview article

Purinergic P2 Receptors
Microglia
Peripheral Nerve Injuries
Nucleotides
Second Messenger Systems
1 Citation (Scopus)

Purinergic regulation of microglia

Saitoh, H., Makoto, T. & Inoue, K., Oct 12 2010, In : Folia Pharmacologica Japonica. 136, 2, p. 93-97 5 p.

Research output: Contribution to journalReview article

Purinergic P2Y12 Receptors
Purinergic P2X4 Receptors
Purinergic P2X7 Receptors
Purinergic P2 Receptors
Microglia
2009
77 Citations (Scopus)

Activation of P2X7 receptors induces CCL3 production in microglial cells through transcription factor NFAT

Kataoka, A., Saitoh, H., Koga, Y., Makoto, T. & Inoue, K., Jan 1 2009, In : Journal of Neurochemistry. 108, 1, p. 115-125 11 p.

Research output: Contribution to journalArticle

Purinergic P2X7 Receptors
NFATC Transcription Factors
CC Chemokines
Transcription Factors
Adenosine Triphosphate
73 Citations (Scopus)

Antidepressants inhibit P2X4 receptor function: A possible involvement in neuropathic pain relief

Nagata, K., Imai, T., Yamashita, T., Makoto, T., Saitoh, H. & Inoue, K., Apr 23 2009, In : Molecular Pain. 5, 20.

Research output: Contribution to journalArticle

Purinergic P2X4 Receptors
Paroxetine
Neuralgia
Antidepressive Agents
Analgesics