Hidetoshi Saitoh &ndash; Research Output

2019

Evidence for detection of rat P2X4 receptor expressed on cells by generating monoclonal antibodies recognizing the native structure

Igawa, T., Kishikawa, S., Abe, Y., Yamashita, T., Nagai, S., Shiroishi, M., Shinozaki, C., Tanaka, H., Saitoh, H., Makoto, T., Inoue, K. & Ueda, T., Jan 1 2019, (Accepted/In press) In : Purinergic Signalling.

Research output: Contribution to journal › Article

Purinergic P2X4 Receptors

Monoclonal Antibodies

Antibodies

Purinergic P2X Receptors

Head

New pharmacological effect of fulvestrant to prevent oxaliplatin-induced neurodegeneration and mechanical allodynia in rats

Yamamoto, S., Yamashita, T., Ito, M., Caaveiro, J. M. M., Egashira, N., Tozaki-Saitoh, H. & Tsuda, M., Jan 1 2019, In : International Journal of Cancer. 145, 8, p. 2107-2113 7 p.

Research output: Contribution to journal › Article

oxaliplatin

Hyperalgesia

Pharmacology

Small Molecule Libraries

Peripheral Nervous System Diseases

2 Citations (Scopus)

Transcription factor MafB contributes to the activation of spinal microglia underlying neuropathic pain development

Saitoh, H., Masuda, J., Kawada, R., Kojima, C., Yoneda, S., Masuda, T., Inoue, K. & Makoto, T., Apr 1 2019, In : GLIA. 67, 4, p. 729-740 12 p.

Research output: Contribution to journal › Article

MafB Transcription Factor

Peripheral Nerve Injuries

Microglia

Neuralgia

Hypersensitivity

2018

3 Citations (Scopus)

Astrocytic Ca²⁺ responses in the spinal dorsal horn by noxious stimuli to the skin

Yoshihara, K., Matsuda, T., Koro, Y., Saitoh, H., Inoue, K. & Makoto, T., May 1 2018, In : Journal of Pharmacological Sciences. 137, 1, p. 101-104 4 p.

Research output: Contribution to journal › Article

Astrocytes

Skin

Automatic Data Processing

Photons

Formaldehyde

8 Citations (Scopus)

Optogenetic activation of non-nociceptive aβ fibers induces neuropathic pain-like sensory and emotional behaviors after nerve injury in rats

Tashima, R., Koga, K., Sekine, M., Kanehisa, K., Kohro, Y., Tominaga, K., Matsushita, K., Tozaki-Saitoh, H., Fukazawa, Y., Inoue, K., Yawo, H., Furue, H. & Tsuda, M., Jan 1 2018, In : eNeuro. 5, 1, e0450-17.2018.

Research output: Contribution to journal › Article

Optogenetics

Peripheral Nerve Injuries

Neuralgia

Myelinated Nerve Fibers

Wounds and Injuries

5 Citations (Scopus)

Temporal kinetics of microgliosis in the spinal dorsal horn after peripheral nerve injury in rodents

Kohno, K., Kitano, J., Koro, Y., Saitoh, H., Inoue, K. & Makoto, T., Jan 1 2018, In : Biological and Pharmaceutical Bulletin. 41, 7, p. 1096-1102 7 p.

Research output: Contribution to journal › Article

Peripheral Nerve Injuries

Rodentia

Microglia

Neuralgia

S Phase

19 Citations (Scopus)

Top-down descending facilitation of spinal sensory excitatory transmission from the anterior cingulate cortex

Chen, T., Taniguchi, W., Chen, Q. Y., Tozaki-Saitoh, H., Song, Q., Liu, R. H., Koga, K., Matsuda, T., Kaito-Sugimura, Y., Wang, J., Li, Z. H., Lu, Y. C., Inoue, K., Tsuda, M., Li, Y. Q., Nakatsuka, T. & Zhuo, M., Dec 1 2018, In : Nature communications. 9, 1, 1886.

Research output: Contribution to journal › Article

cortexes

Gyrus Cinguli

pain

Modulation

Synaptic Transmission

2017

1 Citation (Scopus)

Chemogenetic silencing of GABAergic dorsal horn interneurons induces morphine-resistant spontaneous nocifensive behaviours

Koga, K., Kanehisa, K., Kohro, Y., Shiratori-Hayashi, M., Tozaki-Saitoh, H., Inoue, K., Furue, H. & Tsuda, M., Dec 1 2017, In : Scientific reports. 7, 1, 4739.

Research output: Contribution to journal › Article

Interneurons

Morphine

N-Methyl-D-Aspartate Receptors

Designer Drugs

Substantia Gelatinosa

4 Citations (Scopus)

P2Y12 receptors in primary microglia activate nuclear factor of activated T-cell signaling to induce C–C chemokine 3 expression

Tozaki-Saitoh, H., Miyata, H., Yamashita, T., Matsushita, K., Tsuda, M. & Inoue, K., Apr 1 2017, In : Journal of Neurochemistry. 141, 1, p. 100-110 11 p.

Research output: Contribution to journal › Article

NFATC Transcription Factors

Cell signaling

CC Chemokines

Microglia

Adenosine Diphosphate

2016

31 Citations (Scopus)

A novel P2X4 receptor-selective antagonist produces anti-allodynic effect in a mouse model of herpetic pain

Matsumura, Y., Yamashita, T., Sasaki, A., Nakata, E., Kohno, K., Masuda, T., Tozaki-Saitoh, H., Imai, T., Kuraishi, Y., Tsuda, M. & Inoue, K., Aug 31 2016, In : Scientific reports. 6, 32461.

Research output: Contribution to journal › Article

Purinergic P2X4 Receptors

Chronic Pain

Acute Pain

Pain

Down-Regulation

16 Citations (Scopus)

Bone marrow-derived cells in the population of spinal microglia after peripheral nerve injury

Tashima, R., Mikuriya, S., Tomiyama, D., Shiratori, M., Yamashita, T., Koro, Y., Saitoh, H., Inoue, K. & Makoto, T., Mar 23 2016, In : Scientific reports. 6, 23701.

Research output: Contribution to journal › Article

Peripheral Nerve Injuries

Microglia

Bone Marrow Cells

Population

Spinal Cord

48 Citations (Scopus)

Dorsal horn neurons release extracellular ATP in a VNUT-dependent manner that underlies neuropathic pain

Masuda, T., Ozono, Y., Mikuriya, S., Kohro, Y., Tozaki-Saitoh, H., Iwatsuki, K., Uneyama, H., Ichikawa, R., Salter, M. W., Tsuda, M. & Inoue, K., Aug 12 2016, In : Nature communications. 7, 12529.

Research output: Contribution to journal › Article

Posterior Horn Cells

transporter

pain

adenosine triphosphate

nucleotides

18 Citations (Scopus)

Duloxetine inhibits microglial P2X4 receptor function and alleviates neuropathic pain after peripheral nerve injury

Yamashita, T., Yamamoto, S., Zhang, J., Kometani, M., Tomiyama, D., Kohno, K., Tozaki-Saitoh, H., Inoue, K. & Tsuda, M., Oct 2016, In : PloS one. 11, 10, e0165189.

Research output: Contribution to journal › Article

Purinergic P2X4 Receptors

Peripheral Nerve Injuries

peripheral nerves

Neuralgia

pain

29 Citations (Scopus)

Purinergic P2Y₆ receptors heterodimerize with angiotensin AT1 receptors to promote angiotensin II-induced hypertension

Nishimura, A., Sunggip, C., Tozaki-Saitoh, H., Shimauchi, T., Numaga-Tomita, T., Hirano, K., Ide, T., Boeynaems, J. M., Kurose, H., Tsuda, M., Robaye, B., Inoue, K. & Nishida, M., Jan 19 2016, In : Science Signaling. 9, 411, aac9187.

Research output: Contribution to journal › Article

Purinergic Receptors

Angiotensin Type 1 Receptor

Angiotensin II

Hypertension

Arrestin

2015

25 Citations (Scopus)

A new minimally-invasive method for microinjection into the mouse spinal dorsal horn

Kohro, Y., Sakaguchi, E., Tashima, R., Tozaki-Saitoh, H., Okano, H., Inoue, K. & Tsuda, M., Sep 21 2015, In : Scientific reports. 5, 14306.

Research output: Contribution to journal › Article

Microinjections

Laminectomy

Inflammation

Gene Expression

Peripheral Nerve Injuries

59 Citations (Scopus)

STAT3-dependent reactive astrogliosis in the spinal dorsal horn underlies chronic itch

Shiratori, M., Koga, K., Saitoh, H., Koro, Y., Toyonaga, H., Yamaguchi, C., Hasegawa, A., Nakahara, T., Hachisuka, J., Akira, S., Okano, H., Furue, M., Inoue, K. & Makoto, T., Aug 8 2015, In : Nature medicine. 21, 8, p. 927-931 5 p.

Research output: Contribution to journal › Article

STAT3 Transcription Factor

Lipocalins

Atopic Dermatitis

Dermatitis

Gastrin-Releasing Peptide

21 Citations (Scopus)

Transcription factor IRF1 is responsible for IRF8-mediated IL-1β expression in reactive microglia

Masuda, T., Iwamoto, S., Mikuriya, S., Saitoh, H., Tamura, T., Makoto, T. & Inoue, K., Sep 4 2015, In : Journal of Pharmacological Sciences. 128, 4, p. 216-220 5 p.

Research output: Contribution to journal › Article

Microglia

Interleukin-1

Transcription Factors

Gene Expression

Up-Regulation

2014

21 Citations (Scopus)

Acute hyperglycemia impairs functional improvement after spinal cord injury in mice and humans

Kobayakawa, K., Kumamaru, H., Saiwai, H., Kubota, K., Ohkawa, Y., Kishimoto, J., Yokota, K., Ideta, R., Shiba, K., Tozaki-Saitoh, H., Inoue, K., Iwamoto, Y. & Okada, S., Oct 1 2014, In : Science Translational Medicine. 6, 256, 256ra137.

Research output: Contribution to journal › Article

Spinal Cord Injuries

Hyperglycemia

Obese Mice

Nervous System Trauma

Blood Glucose

37 Citations (Scopus)

Chemokine (C-C motif) receptor 5 Is an important pathological regulator in the development and maintenance of neuropathic pain

Matsushita, K., Tozaki-Saitoh, H., Kojima, C., Masuda, T., Tsuda, M., Inoue, K. & Hoka, S., Jun 2014, In : Anesthesiology. 120, 6, p. 1491-1503 13 p.

Research output: Contribution to journal › Article

CCR Receptors

Neuralgia

Hyperalgesia

Chemokine CCL3

Maintenance

10 Citations (Scopus)

Interferon regulatory factor 8 expressed in microglia contributes to tactile allodynia induced by repeated cold stress in rodents

Akagi, T., Matsumura, Y., Yasui, M., Minami, E., Inoue, H., Masuda, T., Saitoh, H., Tamura, T., Mizumura, K., Makoto, T., Kiyama, H. & Inoue, K., Jan 1 2014, In : Journal of Pharmacological Sciences. 126, 2, p. 172-176 5 p.

Research output: Contribution to journal › Article

Hyperalgesia

Microglia

Rodentia

interferon regulatory factor-8

Knockout Mice

27 Citations (Scopus)

Involvement of the chemokine CCL3 and the purinoceptor P2X7 in the spinal cord in paclitaxel-induced mechanical allodynia

Ochi-ishi, R., Nagata, K., Inoue, T., Tozaki-Saitoh, H., Tsuda, M. & Inoue, K., Aug 15 2014, In : Molecular Pain. 10, 1, 53.

Research output: Contribution to journal › Article

Purinergic P2X7 Receptors

CC Chemokines

Hyperalgesia

Paclitaxel

Chemokines

13 Citations (Scopus)

IRF8 is a transcriptional determinant for microglial motility

Masuda, T., Nishimoto, N., Tomiyama, D., Matsuda, T., Saitoh, H., Tamura, T., Kohsaka, S., Makoto, T. & Inoue, K., Jan 1 2014, In : Purinergic Signalling. 10, 3, p. 515-521 7 p.

Research output: Contribution to journal › Article

Microglia

Chemotaxis

Adenosine Triphosphate

Complement C5a

interferon regulatory factor-8

Spinal cord is the primary site of action of the cannabinoid CB₂ receptor agonist JWH133 that suppresses neuropathic pain: Possible involvement of microglia

Shimoyama, H., Makoto, T., Masuda, T., Yoshinaga, R., Tsukamoto, K., Saitoh, H. & Inoue, K., Jan 1 2014, In : Open Pain Journal. 7, 1

Research output: Contribution to journal › Article

Cannabinoid Receptor Agonists

Microglia

Neuralgia

Cannabinoid Receptor CB2

Spinal Cord

76 Citations (Scopus)

Transcription factor IRF5 drives P2X4R⁺-reactive microglia gating neuropathic pain

Masuda, T., Iwamoto, S., Yoshinaga, R., Tozaki-Saitoh, H., Nishiyama, A., Mak, T. W., Tamura, T., Tsuda, M. & Inoue, K., May 13 2014, In : Nature communications. 5, 3771.

Research output: Contribution to journal › Article

Purinergic P2X4 Receptors

Interferon Regulatory Factors

interferon

pain

Microglia

2013

49 Citations (Scopus)

The intrinsic microglial molecular clock controls synaptic strength via the circadian expression of cathepsin S

Hayashi, Y., Koyanagi, S., Kusunose, N., Okada, R., Wu, Z., Tozaki-Saitoh, H., Ukai, K., Kohsaka, S., Inoue, K., Ohdo, S. & Nakanishi, H., Oct 14 2013, In : Scientific reports. 3, 2744.

Research output: Contribution to journal › Article

cathepsin S

Microglia

Cats

Neurons

Spine

2012

53 Citations (Scopus)

CCL2 promotes P2X4 receptor trafficking to the cell surface of microglia

Toyomitsu, E., Tsuda, M., Yamashita, T., Tozaki-Saitoh, H., Tanaka, Y. & Inoue, K., Jun 1 2012, In : Purinergic Signalling. 8, 2, p. 301-310 10 p.

Research output: Contribution to journal › Article

Purinergic P2X4 Receptors

Microglia

Lysosomes

Exocytosis

Green Fluorescent Proteins

11 Citations (Scopus)

Involvement of protein kinase D in uridine diphosphate-induced microglial macropinocytosis and phagocytosis

Uesugi, A., Kataoka, A., Saitoh, H., Koga, Y., Makoto, T., Robaye, B., Boeynaems, J. M. & Inoue, K., Jul 1 2012, In : GLIA. 60, 7, p. 1094-1105 12 p.

Research output: Contribution to journal › Article

Uridine Diphosphate

Phagocytosis

Microglia

Microspheres

Vacuoles

130 Citations (Scopus)

IRF8 Is a Critical Transcription Factor for Transforming Microglia into a Reactive Phenotype

Masuda, T., Makoto, T., Yoshinaga, R., Saitoh, H., Ozato, K., Tamura, T. & Inoue, K., Mar 19 2012, In : Cell Reports. 1, 4, p. 334-340 7 p.

Research output: Contribution to journal › Article

Microglia

Transcription Factors

Phenotype

Peripheral Nerve Injuries

Gene expression

4 Citations (Scopus)

P2X4R and P2X7R in neuropathic pain

Makoto, T., Hidetoshi, T. S. & Kazuhide, I., Jul 1 2012, In : Wiley Interdisciplinary Reviews: Membrane Transport and Signaling. 1, 4, p. 513-521 9 p.

Research output: Contribution to journal › Article

Neuralgia

Purinergic Receptors

Microglia

Purinergic P2 Receptors

Posterior Horn Cells

2011

55 Citations (Scopus)

Astrocytic P2Y₁ receptor is involved in the regulation of cytokine/chemokine transcription and cerebral damage in a rat model of cerebral ischemia

Kuboyama, K., Harada, H., Tozaki-Saitoh, H., Tsuda, M., Ushijima, K. & Inoue, K., Sep 1 2011, In : Journal of Cerebral Blood Flow and Metabolism. 31, 9, p. 1930-1941 12 p.

Research output: Contribution to journal › Article

Purinergic P2Y1 Receptors

Middle Cerebral Artery Infarction

Brain Ischemia

Chemokines

Chemokine CXCL10

4 Citations (Scopus)

Involvement of vasodilator-stimulated phosphoprotein in UDP-induced microglial actin aggregation via PKC- and Rho-dependent pathways

Kataoka, A., Koga, Y., Uesugi, A., Tozaki-Saitoh, H., Tsuda, M. & Inoue, K., Dec 1 2011, In : Purinergic Signalling. 7, 4, p. 403-411 9 p.

Research output: Contribution to journal › Article

Uridine Diphosphate

Actins

Microglia

Phosphorylation

Microfilament Proteins

144 Citations (Scopus)

JAK-STAT3 pathway regulates spinal astrocyte proliferation and neuropathic pain maintenance in rats

Tsuda, M., Kohro, Y., Yano, T., Tsujikawa, T., Kitano, J., Tozaki-Saitoh, H., Koyanagi, S., Ohdo, S., Ji, R. R., Salter, M. W. & Inoue, K., Apr 1 2011, In : Brain. 134, 4, p. 1127-1139 13 p.

Research output: Contribution to journal › Article

Neuralgia

STAT3 Transcription Factor

Astrocytes

Maintenance

Janus Kinases

97 Citations (Scopus)

Neuronal CCL21 up-regulates microglia P2X4 expression and initiates neuropathic pain development

Biber, K., Tsuda, M., Tozaki-Saitoh, H., Tsukamoto, K., Toyomitsu, E., Masuda, T., Boddeke, H. & Inoue, K., May 4 2011, In : EMBO Journal. 30, 9, p. 1864-1873 10 p.

Research output: Contribution to journal › Article

Purinergic P2X4 Receptors

Hyperalgesia

Microglia

Neuralgia

Up-Regulation

31 Citations (Scopus)

Reduced spinal microglial activation and neuropathic pain after nerve injury in mice lacking all three nitric oxide synthases

Kuboyama, K., Makoto, T., Tsutsui, M., Toyohara, Y., Saitoh, H., Shimokawa, H., Yanagihara, N. & Inoue, K., Jul 14 2011, In : Molecular Pain. 7, 50.

Research output: Contribution to journal › Article

Neuralgia

Nitric Oxide Synthase

Hyperalgesia

Wounds and Injuries

Pain

2010

49 Citations (Scopus)

Nerve injury-activated microglia engulf myelinated axons in a P2Y12 signaling-dependent manner in the dorsal horn

Maeda, M., Tsuda, M., Tozaki-Saitoh, H., Inoue, K. & Kiyama, H., Nov 15 2010, In : GLIA. 58, 15, p. 1838-1846 9 p.

Research output: Contribution to journal › Article

Microglia

Axons

Wounds and Injuries

Neuralgia

Purinergic P2 Receptors

80 Citations (Scopus)

P2X7 receptor activation induces CXCL2 production in microglia through NFAT and PKC/MAPK pathways

Shiratori, M., Saitoh, H., Yoshitake, M., Makoto, T. & Inoue, K., Jan 1 2010, In : Journal of Neurochemistry. 114, 3, p. 810-819 10 p.

Research output: Contribution to journal › Article

Purinergic P2X7 Receptors

NFATC Transcription Factors

Microglia

Adenosine Triphosphate

Chemical activation

2009

80 Citations (Scopus)

Activation of P2X₇ receptors induces CCL3 production in microglial cells through transcription factor NFAT

Kataoka, A., Saitoh, H., Koga, Y., Makoto, T. & Inoue, K., Jan 1 2009, In : Journal of Neurochemistry. 108, 1, p. 115-125 11 p.

Research output: Contribution to journal › Article

Purinergic P2X7 Receptors

NFATC Transcription Factors

CC Chemokines

Transcription Factors

Adenosine Triphosphate

73 Citations (Scopus)

Antidepressants inhibit P2X₄ receptor function: A possible involvement in neuropathic pain relief

Nagata, K., Imai, T., Yamashita, T., Makoto, T., Saitoh, H. & Inoue, K., Apr 23 2009, In : Molecular Pain. 5, 20.

Research output: Contribution to journal › Article

Purinergic P2X4 Receptors

Paroxetine

Neuralgia

Antidepressive Agents

Analgesics

117 Citations (Scopus)

Behavioral phenotypes of mice lacking purinergic P2X₄ receptors in acute and chronic pain assays

Makoto, T., Kuboyama, K., Inoue, T., Nagata, K., Saitoh, H. & Inoue, K., Jun 11 2009, In : Molecular Pain. 5, 28.

Research output: Contribution to journal › Article

Purinergic P2X4 Receptors

Acute Pain

Chronic Pain

Hyperalgesia

Phenotype

150 Citations (Scopus)

IFN-γ receptor signaling mediates spinal microglia activation driving neuropathic pain

Tsuda, M., Masuda, T., Kitano, J., Shimoyama, H., Tozaki-Saitoh, H. & Inoue, K., May 12 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 19, p. 8032-8037 6 p.

Research output: Contribution to journal › Article

Microglia

Neuralgia

Hyperalgesia

Pain

Purinergic P2X4 Receptors

22 Citations (Scopus)

Intrathecal delivery of PDGF produces tactile allodynia through its receptors in spinal microglia

Masuda, J., Makoto, T., Saitoh, H. & Inoue, K., May 10 2009, In : Molecular Pain. 5, 23.

Research output: Contribution to journal › Article

Platelet-Derived Growth Factor

Hyperalgesia

Microglia

Neuralgia

Platelet-Derived Growth Factor Receptors

44 Citations (Scopus)

Mechanisms underlying fibronectin-induced up-regulation of P2X ₄R expression in microglia: Distinct roles of PI3K-Akt and MEK-ERK signalling pathways

Tsuda, M., Toyomitsu, E., Kometani, M., Tozaki-Saitoh, H. & Inoue, K., Sep 1 2009, In : Journal of Cellular and Molecular Medicine. 13, 9 B, p. 3251-3259 9 p.

Research output: Contribution to journal › Article

Phosphatidylinositol 3-Kinase

Mitogen-Activated Protein Kinase Kinases

Extracellular Signal-Regulated MAP Kinases

Microglia

Fibronectins

73 Citations (Scopus)

P2Y₁ receptor signaling enhances neuroprotection by astrocytes against oxidative stress via IL-6 release in hippocampal cultures

Fujita, T., Saitoh, H. & Inoue, K., Jun 8 2009, In : GLIA. 57, 3, p. 244-257 14 p.

Research output: Contribution to journal › Article

Purinergic P2Y1 Receptors

Astrocytes

Interleukin-6

Oxidative Stress

Adenosine Triphosphate

2008

108 Citations (Scopus)

Activation of dorsal horn microglia contributes to diabetes-induced tactile allodynia via extracellular signal-regulated protein kinase signaling

Makoto, T., Ueno, H., Kataoka, A., Saitoh, H. & Inoue, K., Mar 1 2008, In : GLIA. 56, 4, p. 378-386 9 p.

Research output: Contribution to journal › Article

Hyperalgesia

Extracellular Signal-Regulated MAP Kinases

Microglia

Protein Kinases

Streptozocin

88 Citations (Scopus)

Lyn tyrosine kinase is required for P2X₄ receptor upregulation and neuropathic pain after peripheral nerve injury

Tsuda, M., Tozaki-Saitoh, H., Masuda, T., Toyomitsu, E., Tezuka, T., Yamamoto, T. & Inoue, K., Jan 1 2008, In : GLIA. 56, 1, p. 50-58 9 p.

Research output: Contribution to journal › Article

Purinergic P2X4 Receptors

Peripheral Nerve Injuries

src-Family Kinases

Neuralgia

Protein-Tyrosine Kinases

190 Citations (Scopus)

P2Y₁₂ receptors in spinal microglia are required for neuropathic pain after peripheral nerve injury

Saitoh, H., Makoto, T., Miyata, H., Ueda, K., Kohsaka, S. & Inoue, K., May 7 2008, In : Journal of Neuroscience. 28, 19, p. 4949-4956 8 p.

Research output: Contribution to journal › Article

Peripheral Nerve Injuries

Microglia

Neuralgia

Hyperalgesia

clopidogrel

127 Citations (Scopus)

P2Y₆ receptor-Gα_12/13 signalling in cardiomyocytes triggers pressure overload-induced cardiac fibrosis

Nishida, M., Sato, Y., Uemura, A., Narita, Y., Saitoh, H., Michio, N., Ide, T., Suzuki, K., Inoue, K., Nagao, T. & Kurose, H., Dec 3 2008, In : EMBO Journal. 27, 23, p. 3104-3115 12 p.

Research output: Contribution to journal › Article

Cardiac Myocytes

Fibrosis

Genes

Transforming Growth Factors

GTP-Binding Proteins

2007

23 Citations (Scopus)

Reduced pain behaviors and extracellular signal-related protein kinase activation in primary sensory neurons by peripheral tissue injury in mice lacking platelet-activating factor receptor

Makoto, T., Ishii, S., Masuda, T., Hasegawa, S., Nakamura, K., Nagata, K., Yamashita, T., Furue, H., Saitoh, H., Yoshimura, M., Koizumi, S., Shimizu, T. & Inoue, K., Sep 1 2007, In : Journal of Neurochemistry. 102, 5, p. 1658-1668 11 p.

Research output: Contribution to journal › Article

Sensory Receptor Cells

Protein Kinases

Neurons

Chemical activation

Tissue

2006

10 Citations (Scopus)

Retinoic acids increase P2X₂ receptor expression through the 5′-flanking region of P2rx2 gene in rat phaeochromocytoma PC-12 cells

Saitoh, H., Koizumi, S., Sato, Y., Makoto, T., Nagao, T. & Inoue, K., Jun 27 2006, In : Molecular Pharmacology. 70, 1, p. 319-328 10 p.

Research output: Contribution to journal › Article

Purinergic P2X2 Receptors

5' Flanking Region

Pheochromocytoma

Tretinoin

Genes

2005

46 Citations (Scopus)

Characterization of multiple P2X receptors in cultured normal human epidermal keratinocytes

Inoue, K., Denda, M., Saitoh, H., Fujishita, K., Koizumi, S. & Inoue, K., Jan 1 2005, In : Journal of Investigative Dermatology. 124, 4, p. 756-763 8 p.

Research output: Contribution to journal › Article

Keratinocytes

Adenosine Triphosphate

Purinergic P2X3 Receptors

Purinergic P2X7 Receptors

Purinergic P2X1 Receptors