Research Output per year
Research Output 2005 2019
Evidence for detection of rat P2X4 receptor expressed on cells by generating monoclonal antibodies recognizing the native structure
Igawa, T., Kishikawa, S., Abe, Y., Yamashita, T., Nagai, S., Shiroishi, M., Shinozaki, C., Tanaka, H., Saitoh, H., Makoto, T., Inoue, K. & Ueda, T., Jan 1 2019, (Accepted/In press) In : Purinergic Signalling.Research output: Contribution to journal › Article
New pharmacological effect of fulvestrant to prevent oxaliplatin-induced neurodegeneration and mechanical allodynia in rats
Yamamoto, S., Yamashita, T., Ito, M., Caaveiro, J. M. M., Egashira, N., Tozaki-Saitoh, H. & Tsuda, M., Jan 1 2019, In : International Journal of Cancer. 145, 8, p. 2107-2113 7 p.Research output: Contribution to journal › Article
Transcription factor MafB contributes to the activation of spinal microglia underlying neuropathic pain development
Saitoh, H., Masuda, J., Kawada, R., Kojima, C., Yoneda, S., Masuda, T., Inoue, K. & Makoto, T., Apr 1 2019, In : GLIA. 67, 4, p. 729-740 12 p.Research output: Contribution to journal › Article
Astrocytic Ca2+ responses in the spinal dorsal horn by noxious stimuli to the skin
Yoshihara, K., Matsuda, T., Koro, Y., Saitoh, H., Inoue, K. & Makoto, T., May 1 2018, In : Journal of Pharmacological Sciences. 137, 1, p. 101-104 4 p.Research output: Contribution to journal › Article
Optogenetic activation of non-nociceptive aβ fibers induces neuropathic pain-like sensory and emotional behaviors after nerve injury in rats
Tashima, R., Koga, K., Sekine, M., Kanehisa, K., Kohro, Y., Tominaga, K., Matsushita, K., Tozaki-Saitoh, H., Fukazawa, Y., Inoue, K., Yawo, H., Furue, H. & Tsuda, M., Jan 1 2018, In : eNeuro. 5, 1, e0450-17.2018.Research output: Contribution to journal › Article
Temporal kinetics of microgliosis in the spinal dorsal horn after peripheral nerve injury in rodents
Kohno, K., Kitano, J., Koro, Y., Saitoh, H., Inoue, K. & Makoto, T., Jan 1 2018, In : Biological and Pharmaceutical Bulletin. 41, 7, p. 1096-1102 7 p.Research output: Contribution to journal › Article
Top-down descending facilitation of spinal sensory excitatory transmission from the anterior cingulate cortex
Chen, T., Taniguchi, W., Chen, Q. Y., Tozaki-Saitoh, H., Song, Q., Liu, R. H., Koga, K., Matsuda, T., Kaito-Sugimura, Y., Wang, J., Li, Z. H., Lu, Y. C., Inoue, K., Tsuda, M., Li, Y. Q., Nakatsuka, T. & Zhuo, M., Dec 1 2018, In : Nature communications. 9, 1, 1886.Research output: Contribution to journal › Article
Chemogenetic silencing of GABAergic dorsal horn interneurons induces morphine-resistant spontaneous nocifensive behaviours
Koga, K., Kanehisa, K., Kohro, Y., Shiratori-Hayashi, M., Tozaki-Saitoh, H., Inoue, K., Furue, H. & Tsuda, M., Dec 1 2017, In : Scientific reports. 7, 1, 4739.Research output: Contribution to journal › Article
P2Y12 receptors in primary microglia activate nuclear factor of activated T-cell signaling to induce C–C chemokine 3 expression
Tozaki-Saitoh, H., Miyata, H., Yamashita, T., Matsushita, K., Tsuda, M. & Inoue, K., Apr 1 2017, In : Journal of Neurochemistry. 141, 1, p. 100-110 11 p.Research output: Contribution to journal › Article
A novel P2X4 receptor-selective antagonist produces anti-allodynic effect in a mouse model of herpetic pain
Matsumura, Y., Yamashita, T., Sasaki, A., Nakata, E., Kohno, K., Masuda, T., Tozaki-Saitoh, H., Imai, T., Kuraishi, Y., Tsuda, M. & Inoue, K., Aug 31 2016, In : Scientific reports. 6, 32461.Research output: Contribution to journal › Article
Bone marrow-derived cells in the population of spinal microglia after peripheral nerve injury
Tashima, R., Mikuriya, S., Tomiyama, D., Shiratori, M., Yamashita, T., Koro, Y., Saitoh, H., Inoue, K. & Makoto, T., Mar 23 2016, In : Scientific reports. 6, 23701.Research output: Contribution to journal › Article
Dorsal horn neurons release extracellular ATP in a VNUT-dependent manner that underlies neuropathic pain
Masuda, T., Ozono, Y., Mikuriya, S., Kohro, Y., Tozaki-Saitoh, H., Iwatsuki, K., Uneyama, H., Ichikawa, R., Salter, M. W., Tsuda, M. & Inoue, K., Aug 12 2016, In : Nature communications. 7, 12529.Research output: Contribution to journal › Article
Duloxetine inhibits microglial P2X4 receptor function and alleviates neuropathic pain after peripheral nerve injury
Yamashita, T., Yamamoto, S., Zhang, J., Kometani, M., Tomiyama, D., Kohno, K., Tozaki-Saitoh, H., Inoue, K. & Tsuda, M., Oct 2016, In : PloS one. 11, 10, e0165189.Research output: Contribution to journal › Article
Purinergic P2Y6 receptors heterodimerize with angiotensin AT1 receptors to promote angiotensin II-induced hypertension
Nishimura, A., Sunggip, C., Tozaki-Saitoh, H., Shimauchi, T., Numaga-Tomita, T., Hirano, K., Ide, T., Boeynaems, J. M., Kurose, H., Tsuda, M., Robaye, B., Inoue, K. & Nishida, M., Jan 19 2016, In : Science Signaling. 9, 411, aac9187.Research output: Contribution to journal › Article
A new minimally-invasive method for microinjection into the mouse spinal dorsal horn
Kohro, Y., Sakaguchi, E., Tashima, R., Tozaki-Saitoh, H., Okano, H., Inoue, K. & Tsuda, M., Sep 21 2015, In : Scientific reports. 5, 14306.Research output: Contribution to journal › Article
STAT3-dependent reactive astrogliosis in the spinal dorsal horn underlies chronic itch
Shiratori, M., Koga, K., Saitoh, H., Koro, Y., Toyonaga, H., Yamaguchi, C., Hasegawa, A., Nakahara, T., Hachisuka, J., Akira, S., Okano, H., Furue, M., Inoue, K. & Makoto, T., Aug 8 2015, In : Nature medicine. 21, 8, p. 927-931 5 p.Research output: Contribution to journal › Article
Transcription factor IRF1 is responsible for IRF8-mediated IL-1β expression in reactive microglia
Masuda, T., Iwamoto, S., Mikuriya, S., Saitoh, H., Tamura, T., Makoto, T. & Inoue, K., Sep 4 2015, In : Journal of Pharmacological Sciences. 128, 4, p. 216-220 5 p.Research output: Contribution to journal › Article
Acute hyperglycemia impairs functional improvement after spinal cord injury in mice and humans
Kobayakawa, K., Kumamaru, H., Saiwai, H., Kubota, K., Ohkawa, Y., Kishimoto, J., Yokota, K., Ideta, R., Shiba, K., Tozaki-Saitoh, H., Inoue, K., Iwamoto, Y. & Okada, S., Oct 1 2014, In : Science Translational Medicine. 6, 256, 256ra137.Research output: Contribution to journal › Article
Chemokine (C-C motif) receptor 5 Is an important pathological regulator in the development and maintenance of neuropathic pain
Matsushita, K., Tozaki-Saitoh, H., Kojima, C., Masuda, T., Tsuda, M., Inoue, K. & Hoka, S., Jun 2014, In : Anesthesiology. 120, 6, p. 1491-1503 13 p.Research output: Contribution to journal › Article
Interferon regulatory factor 8 expressed in microglia contributes to tactile allodynia induced by repeated cold stress in rodents
Akagi, T., Matsumura, Y., Yasui, M., Minami, E., Inoue, H., Masuda, T., Saitoh, H., Tamura, T., Mizumura, K., Makoto, T., Kiyama, H. & Inoue, K., Jan 1 2014, In : Journal of Pharmacological Sciences. 126, 2, p. 172-176 5 p.Research output: Contribution to journal › Article
Involvement of the chemokine CCL3 and the purinoceptor P2X7 in the spinal cord in paclitaxel-induced mechanical allodynia
Ochi-ishi, R., Nagata, K., Inoue, T., Tozaki-Saitoh, H., Tsuda, M. & Inoue, K., Aug 15 2014, In : Molecular Pain. 10, 1, 53.Research output: Contribution to journal › Article
IRF8 is a transcriptional determinant for microglial motility
Masuda, T., Nishimoto, N., Tomiyama, D., Matsuda, T., Saitoh, H., Tamura, T., Kohsaka, S., Makoto, T. & Inoue, K., Jan 1 2014, In : Purinergic Signalling. 10, 3, p. 515-521 7 p.Research output: Contribution to journal › Article
Spinal cord is the primary site of action of the cannabinoid CB2 receptor agonist JWH133 that suppresses neuropathic pain: Possible involvement of microglia
Shimoyama, H., Makoto, T., Masuda, T., Yoshinaga, R., Tsukamoto, K., Saitoh, H. & Inoue, K., Jan 1 2014, In : Open Pain Journal. 7, 1Research output: Contribution to journal › Article
Transcription factor IRF5 drives P2X4R+-reactive microglia gating neuropathic pain
Masuda, T., Iwamoto, S., Yoshinaga, R., Tozaki-Saitoh, H., Nishiyama, A., Mak, T. W., Tamura, T., Tsuda, M. & Inoue, K., May 13 2014, In : Nature communications. 5, 3771.Research output: Contribution to journal › Article
The intrinsic microglial molecular clock controls synaptic strength via the circadian expression of cathepsin S
Hayashi, Y., Koyanagi, S., Kusunose, N., Okada, R., Wu, Z., Tozaki-Saitoh, H., Ukai, K., Kohsaka, S., Inoue, K., Ohdo, S. & Nakanishi, H., Oct 14 2013, In : Scientific reports. 3, 2744.Research output: Contribution to journal › Article
CCL2 promotes P2X4 receptor trafficking to the cell surface of microglia
Toyomitsu, E., Tsuda, M., Yamashita, T., Tozaki-Saitoh, H., Tanaka, Y. & Inoue, K., Jun 1 2012, In : Purinergic Signalling. 8, 2, p. 301-310 10 p.Research output: Contribution to journal › Article
Involvement of protein kinase D in uridine diphosphate-induced microglial macropinocytosis and phagocytosis
Uesugi, A., Kataoka, A., Saitoh, H., Koga, Y., Makoto, T., Robaye, B., Boeynaems, J. M. & Inoue, K., Jul 1 2012, In : GLIA. 60, 7, p. 1094-1105 12 p.Research output: Contribution to journal › Article
IRF8 Is a Critical Transcription Factor for Transforming Microglia into a Reactive Phenotype
Masuda, T., Makoto, T., Yoshinaga, R., Saitoh, H., Ozato, K., Tamura, T. & Inoue, K., Mar 19 2012, In : Cell Reports. 1, 4, p. 334-340 7 p.Research output: Contribution to journal › Article
P2X4R and P2X7R in neuropathic pain
Makoto, T., Hidetoshi, T. S. & Kazuhide, I., Jul 1 2012, In : Wiley Interdisciplinary Reviews: Membrane Transport and Signaling. 1, 4, p. 513-521 9 p.Research output: Contribution to journal › Article
Astrocytic P2Y1 receptor is involved in the regulation of cytokine/chemokine transcription and cerebral damage in a rat model of cerebral ischemia
Kuboyama, K., Harada, H., Tozaki-Saitoh, H., Tsuda, M., Ushijima, K. & Inoue, K., Sep 1 2011, In : Journal of Cerebral Blood Flow and Metabolism. 31, 9, p. 1930-1941 12 p.Research output: Contribution to journal › Article
Involvement of vasodilator-stimulated phosphoprotein in UDP-induced microglial actin aggregation via PKC- and Rho-dependent pathways
Kataoka, A., Koga, Y., Uesugi, A., Tozaki-Saitoh, H., Tsuda, M. & Inoue, K., Dec 1 2011, In : Purinergic Signalling. 7, 4, p. 403-411 9 p.Research output: Contribution to journal › Article
JAK-STAT3 pathway regulates spinal astrocyte proliferation and neuropathic pain maintenance in rats
Tsuda, M., Kohro, Y., Yano, T., Tsujikawa, T., Kitano, J., Tozaki-Saitoh, H., Koyanagi, S., Ohdo, S., Ji, R. R., Salter, M. W. & Inoue, K., Apr 1 2011, In : Brain. 134, 4, p. 1127-1139 13 p.Research output: Contribution to journal › Article
Neuronal CCL21 up-regulates microglia P2X4 expression and initiates neuropathic pain development
Biber, K., Tsuda, M., Tozaki-Saitoh, H., Tsukamoto, K., Toyomitsu, E., Masuda, T., Boddeke, H. & Inoue, K., May 4 2011, In : EMBO Journal. 30, 9, p. 1864-1873 10 p.Research output: Contribution to journal › Article
Reduced spinal microglial activation and neuropathic pain after nerve injury in mice lacking all three nitric oxide synthases
Kuboyama, K., Makoto, T., Tsutsui, M., Toyohara, Y., Saitoh, H., Shimokawa, H., Yanagihara, N. & Inoue, K., Jul 14 2011, In : Molecular Pain. 7, 50.Research output: Contribution to journal › Article
Nerve injury-activated microglia engulf myelinated axons in a P2Y12 signaling-dependent manner in the dorsal horn
Maeda, M., Tsuda, M., Tozaki-Saitoh, H., Inoue, K. & Kiyama, H., Nov 15 2010, In : GLIA. 58, 15, p. 1838-1846 9 p.Research output: Contribution to journal › Article
P2X7 receptor activation induces CXCL2 production in microglia through NFAT and PKC/MAPK pathways
Shiratori, M., Saitoh, H., Yoshitake, M., Makoto, T. & Inoue, K., Jan 1 2010, In : Journal of Neurochemistry. 114, 3, p. 810-819 10 p.Research output: Contribution to journal › Article
Activation of P2X7 receptors induces CCL3 production in microglial cells through transcription factor NFAT
Kataoka, A., Saitoh, H., Koga, Y., Makoto, T. & Inoue, K., Jan 1 2009, In : Journal of Neurochemistry. 108, 1, p. 115-125 11 p.Research output: Contribution to journal › Article
Antidepressants inhibit P2X4 receptor function: A possible involvement in neuropathic pain relief
Nagata, K., Imai, T., Yamashita, T., Makoto, T., Saitoh, H. & Inoue, K., Apr 23 2009, In : Molecular Pain. 5, 20.Research output: Contribution to journal › Article
Behavioral phenotypes of mice lacking purinergic P2X4 receptors in acute and chronic pain assays
Makoto, T., Kuboyama, K., Inoue, T., Nagata, K., Saitoh, H. & Inoue, K., Jun 11 2009, In : Molecular Pain. 5, 28.Research output: Contribution to journal › Article
IFN-γ receptor signaling mediates spinal microglia activation driving neuropathic pain
Tsuda, M., Masuda, T., Kitano, J., Shimoyama, H., Tozaki-Saitoh, H. & Inoue, K., May 12 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 19, p. 8032-8037 6 p.Research output: Contribution to journal › Article
Intrathecal delivery of PDGF produces tactile allodynia through its receptors in spinal microglia
Masuda, J., Makoto, T., Saitoh, H. & Inoue, K., May 10 2009, In : Molecular Pain. 5, 23.Research output: Contribution to journal › Article
Mechanisms underlying fibronectin-induced up-regulation of P2X 4R expression in microglia: Distinct roles of PI3K-Akt and MEK-ERK signalling pathways
Tsuda, M., Toyomitsu, E., Kometani, M., Tozaki-Saitoh, H. & Inoue, K., Sep 1 2009, In : Journal of Cellular and Molecular Medicine. 13, 9 B, p. 3251-3259 9 p.Research output: Contribution to journal › Article
P2Y1 receptor signaling enhances neuroprotection by astrocytes against oxidative stress via IL-6 release in hippocampal cultures
Fujita, T., Saitoh, H. & Inoue, K., Jun 8 2009, In : GLIA. 57, 3, p. 244-257 14 p.Research output: Contribution to journal › Article
Activation of dorsal horn microglia contributes to diabetes-induced tactile allodynia via extracellular signal-regulated protein kinase signaling
Makoto, T., Ueno, H., Kataoka, A., Saitoh, H. & Inoue, K., Mar 1 2008, In : GLIA. 56, 4, p. 378-386 9 p.Research output: Contribution to journal › Article
Lyn tyrosine kinase is required for P2X4 receptor upregulation and neuropathic pain after peripheral nerve injury
Tsuda, M., Tozaki-Saitoh, H., Masuda, T., Toyomitsu, E., Tezuka, T., Yamamoto, T. & Inoue, K., Jan 1 2008, In : GLIA. 56, 1, p. 50-58 9 p.Research output: Contribution to journal › Article
P2Y12 receptors in spinal microglia are required for neuropathic pain after peripheral nerve injury
Saitoh, H., Makoto, T., Miyata, H., Ueda, K., Kohsaka, S. & Inoue, K., May 7 2008, In : Journal of Neuroscience. 28, 19, p. 4949-4956 8 p.Research output: Contribution to journal › Article
P2Y6 receptor-Gα12/13 signalling in cardiomyocytes triggers pressure overload-induced cardiac fibrosis
Nishida, M., Sato, Y., Uemura, A., Narita, Y., Saitoh, H., Michio, N., Ide, T., Suzuki, K., Inoue, K., Nagao, T. & Kurose, H., Dec 3 2008, In : EMBO Journal. 27, 23, p. 3104-3115 12 p.Research output: Contribution to journal › Article
Reduced pain behaviors and extracellular signal-related protein kinase activation in primary sensory neurons by peripheral tissue injury in mice lacking platelet-activating factor receptor
Makoto, T., Ishii, S., Masuda, T., Hasegawa, S., Nakamura, K., Nagata, K., Yamashita, T., Furue, H., Saitoh, H., Yoshimura, M., Koizumi, S., Shimizu, T. & Inoue, K., Sep 1 2007, In : Journal of Neurochemistry. 102, 5, p. 1658-1668 11 p.Research output: Contribution to journal › Article
Retinoic acids increase P2X2 receptor expression through the 5′-flanking region of P2rx2 gene in rat phaeochromocytoma PC-12 cells
Saitoh, H., Koizumi, S., Sato, Y., Makoto, T., Nagao, T. & Inoue, K., Jun 27 2006, In : Molecular Pharmacology. 70, 1, p. 319-328 10 p.Research output: Contribution to journal › Article
Characterization of multiple P2X receptors in cultured normal human epidermal keratinocytes
Inoue, K., Denda, M., Saitoh, H., Fujishita, K., Koizumi, S. & Inoue, K., Jan 1 2005, In : Journal of Investigative Dermatology. 124, 4, p. 756-763 8 p.Research output: Contribution to journal › Article