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Research Output 2000 2019

  • 1397 Citations
  • 24 h-Index
  • 53 Article
  • 6 Review article
  • 4 Chapter
  • 1 Comment/debate
2019

An impaired intrinsic microglial clock system induces neuroinflammatory alterations in the early stage of amyloid precursor protein knock-in mouse brain

Ni, J., Wu, Z., Meng, J., Saito, T., Saido, T. C., Qing, H. & Nakanishi, H., Aug 30 2019, In : Journal of neuroinflammation. 16, 1, 173.

Research output: Contribution to journalArticle

Open Access
Amyloid beta-Protein Precursor
Microglia
Brain
Alzheimer Disease
Genes
1 Citation (Scopus)

Cathepsin E in neutrophils contributes to the generation of neuropathic pain in experimental autoimmune encephalomyelitis

Harada, Y., Zhang, J., Imari, K., Yamasaki, R., Ni, J., Take, H., Yamamoto, K., Kira, J-I., Nakanishi, H. & Hayashi, Y., Sep 1 2019, In : Pain. 160, 9, p. 2050-2062 13 p.

Research output: Contribution to journalArticle

Cathepsin E
Autoimmune Experimental Encephalomyelitis
Neuralgia
Neutrophils
Hyperalgesia

Effects of zinc gluconate carbon dots in cell imaging and inducing osteoblastic differentiation in vitro

Meng, Y., Yang, M., Wang, L., Liu, D., Yu, W., Wang, W. & Take, H., May 1 2019, In : Journal of Jilin University Medicine Edition. 45, 3, p. 504-510 7 p.

Research output: Contribution to journalArticle

Carbon
Fluorescence
Control Groups
Optical Imaging
Osteocalcin
3 Citations (Scopus)

Increased expression and altered subcellular distribution of cathepsin B in microglia induce cognitive impairment through oxidative stress and inflammatory response in mice

Ni, J., Wu, Z., Stoka, V., Meng, J., Hayashi, Y., Peters, C., Qing, H., Turk, V. & Nakanishi, H., Feb 1 2019, In : Aging cell. 18, 1, e12856.

Research output: Contribution to journalArticle

Cathepsin B
Microglia
Oxidative Stress
Reactive Oxygen Species
Mitochondria

Induction of bone repair in rat calvarial defects using a combination of hydroxyapatite with phosphatidylserine liposomes

Hatakeyama, J., Anan, H., Hatakeyama, Y., Matsumoto, N., Takayama, F., Wu, Z., Matsuzaki, E., Minakami, M., Izumi, T. & Nakanishi, H., Jan 1 2019, In : Journal of Oral Science. 61, 1, p. 111-118 8 p.

Research output: Contribution to journalArticle

Open Access
Phosphatidylserines
Durapatite
Liposomes
Bone and Bones
Bone Regeneration
2018
1 Citation (Scopus)

Brazilian Green Propolis Prevents Cognitive Decline into Mild Cognitive Impairment in Elderly People Living at High Altitude

Zhu, A., Take, H., Zhong, X., Ni, J., Li, Y., Meng, J., Du, C., Zhao, X., Nakanishi, H. & Wu, S., Jan 1 2018, In : Journal of Alzheimer's Disease. 63, 2, p. 551-560 10 p.

Research output: Contribution to journalArticle

Propolis
Placebos
Inflammation
Serum
Interleukin-1

Cathepsin H deficiency in mice induces excess Th1 cell activation and early-onset of EAE though impairment of toll-like receptor 3 cascade

Okada, R., Zhang, X., Harada, Y., Take, H. & Nakanishi, H., May 1 2018, In : Inflammation Research. 67, 5, p. 371-374 4 p.

Research output: Contribution to journalArticle

Cathepsin H
Toll-Like Receptor 3
Th1 Cells
Autoimmune Experimental Encephalomyelitis
Interferon Regulatory Factor-3
PAR-2 Receptor
Porphyromonas gingivalis
Microglia
Cell Movement
Infection
2 Citations (Scopus)

The critical role of IL-10 in the antineuroinflammatory and antioxidative effects of Rheum tanguticum on activated microglia

Meng, J., Ni, J., Wu, Z., Jiang, M., Zhu, A., Qing, H. & Nakanishi, H., Jan 1 2018, In : Oxidative medicine and cellular longevity. 2018, 1083596.

Research output: Contribution to journalArticle

Rheum
Microglia
Interleukin-10
Catechin
Interleukin-1
2017
2 Citations (Scopus)

Boi-ogi-to (TJ-20), a Kampo Formula, Suppresses the Inflammatory Bone Destruction and the Expression of Cytokines in the Synovia of Ankle Joints of Adjuvant Arthritic Rats

Zhang, X., Wu, Z., Liu, Y., Ni, J., Deng, C., Zhao, B., Nakanishi, H., He, J. & Yan, X., Jan 1 2017, In : Evidence-based Complementary and Alternative Medicine. 2017, 3679295.

Research output: Contribution to journalArticle

Kampo Medicine
Experimental Arthritis
Ankle Joint
Synovial Fluid
Rheumatoid Arthritis
24 Citations (Scopus)

Cathepsin B plays a critical role in inducing Alzheimer's disease-like phenotypes following chronic systemic exposure to lipopolysaccharide from Porphyromonas gingivalis in mice

Take, H., Ni, J., Liu, Y., Teeling, J. L., Takayama, F., Collcutt, A., Ibbett, P. & Nakanishi, H., Oct 1 2017, In : Brain, Behavior, and Immunity. 65, p. 350-361 12 p.

Research output: Contribution to journalArticle

Cathepsin B
Porphyromonas gingivalis
Microglia
Lipopolysaccharides
Alzheimer Disease
5 Citations (Scopus)

Dysfunction in diurnal synaptic responses and social behavior abnormalities in cathepsin S-deficient mice

Takayama, F., Zhang, X., Hayashi, Y., Take, H. & Nakanishi, H., Aug 19 2017, In : Biochemical and Biophysical Research Communications. 490, 2, p. 447-452 6 p.

Research output: Contribution to journalArticle

cathepsin S
Social Behavior
Neurons
Clocks
Cats
8 Citations (Scopus)

Infection of microglia with Porphyromonas gingivalis promotes cell migration and an inflammatory response through the gingipain-mediated activation of protease-activated receptor-2 in mice

Liu, Y., Take, H., Nakanishi, Y., Ni, J., Hayashi, Y., Takayama, F., Zhou, Y., Kadawaki, T. & Nakanishi, H., Dec 1 2017, In : Scientific reports. 7, 1, 11759.

Research output: Contribution to journalArticle

PAR-2 Receptor
Porphyromonas gingivalis
Extracellular Signal-Regulated MAP Kinases
Microglia
Cell Movement
1 Citation (Scopus)

Overexpression of Cathepsin E Interferes with Neuronal Differentiation of P19 Embryonal Teratocarcinoma Cells by Degradation of N-cadherin

Harada, Y., Takayama, F., Tanabe, K., Ni, J., Hayashi, Y., Yamamoto, K., Take, H. & Nakanishi, H., Apr 1 2017, In : Cellular and molecular neurobiology. 37, 3, p. 437-443 7 p.

Research output: Contribution to journalArticle

Cathepsin E
Teratocarcinoma
Cadherins
Neurons
Cell Differentiation
13 Citations (Scopus)

The Neuroprotective Effects of Brazilian Green Propolis on Neurodegenerative Damage in Human Neuronal SH-SY5Y Cells

Ni, J., Wu, Z., Meng, J., Zhu, A., Zhong, X., Wu, S. & Nakanishi, H., Jan 1 2017, In : Oxidative medicine and cellular longevity. 2017, 7984327.

Research output: Contribution to journalArticle

Propolis
Neuroprotective Agents
Brain-Derived Neurotrophic Factor
Cytoskeleton
Oxidative stress
2016
1 Citation (Scopus)

An EP2 Agonist Facilitates NMDA-Induced Outward Currents and Inhibits Dendritic Beading through Activation of BK Channels in Mouse Cortical Neurons

Hayashi, Y., Morinaga, S., Liu, X., Zhang, J., Wu, Z., Yokoyama, T. & Nakanishi, H., Jan 1 2016, In : Mediators of Inflammation. 2016, 5079597.

Research output: Contribution to journalArticle

Large-Conductance Calcium-Activated Potassium Channels
N-Methylaspartate
Neurons
Protein Kinase Inhibitors
Cyclic AMP-Dependent Protein Kinases
24 Citations (Scopus)

BK channels in microglia are required for morphine-induced hyperalgesia

Hayashi, Y., Morinaga, S., Zhang, J., Satoh, Y., Meredith, A. L., Nakata, T., Take, H., Kohsaka, S., Inoue, K. & Nakanishi, H., May 31 2016, In : Nature communications. 7, 11697.

Research output: Contribution to journalArticle

morphine
Large-Conductance Calcium-Activated Potassium Channels
Hyperalgesia
Microglia
Morphine
11 Citations (Scopus)

Cathepsin B Regulates Collagen Expression by Fibroblasts via Prolonging TLR2/NF-κB Activation

Li, X., Wu, Z., Ni, J., Liu, Y., Meng, J., Yu, W., Nakanishi, H. & Zhou, Y., Jan 1 2016, In : Oxidative medicine and cellular longevity. 2016, 7894247.

Research output: Contribution to journalArticle

Cathepsin B
Fibroblasts
Collagen
Chemical activation
yeast proteinase B
11 Citations (Scopus)

Diurnal dynamic behavior of microglia in response to infected bacteria through the UDP-P2Y 6 receptor system

Takayama, F., Hayashi, Y., Wu, Z., Liu, Y. & Nakanishi, H., Jul 21 2016, In : Scientific reports. 6, 30006.

Research output: Contribution to journalArticle

Porphyromonas gingivalis
Uridine Diphosphate
Microglia
Bacteria
Adenosine Triphosphate
22 Citations (Scopus)

Nutrients, Microglia Aging, and Brain Aging

Take, H., Yu, J., Zhu, A. & Nakanishi, H., Jan 1 2016, In : Oxidative medicine and cellular longevity. 2016, 7498528.

Research output: Contribution to journalReview article

Microglia
Nutrients
Brain
Aging of materials
Food
2015
16 Citations (Scopus)

Cathepsin D deficiency induces oxidative damage in brain pericytes and impairs the blood-brain barrier

Okada, R., Take, H., Zhu, A., Ni, J., Zhang, J., Yoshito, Y., Peters, C., Saftig, P. & Nakanishi, H., Jan 1 2015, In : Molecular and Cellular Neuroscience. 64, p. 51-60 10 p.

Research output: Contribution to journalArticle

Pericytes
Cathepsin D
Blood-Brain Barrier
Brain
Blood Cells
9 Citations (Scopus)

Lessons from Microglia Aging for the Link between Inflammatory Bone Disorders and Alzheimer's Disease

Wu, Z. & Nakanishi, H., Jan 1 2015, In : Journal of Immunology Research. 2015, 471342.

Research output: Contribution to journalReview article

Bone Diseases
Microglia
Periodontitis
Alzheimer Disease
Bone and Bones
22 Citations (Scopus)

The critical role of proteolytic relay through cathepsins B and E in the phenotypic change of microglia/macrophage

Ni, J., Take, H., Peterts, C., Yamamoto, K., Qing, H. & Nakanishi, H., Sep 9 2015, In : Journal of Neuroscience. 35, 36, p. 12488-12501 14 p.

Research output: Contribution to journalArticle

Cathepsin E
Cathepsin B
Microglia
Macrophages
Phenotype
2 Citations (Scopus)

The downward spiral of periodontitis and diabetes in Alzheimer's disease: Extending healthy life expectancy through oral health

Nakanishi, H. & Take, H., Jan 1 2015, In : Journal of Oral Biosciences. 57, 3, p. 139-142 4 p.

Research output: Contribution to journalReview article

Periodontitis
Oral Health
Medical problems
Life Expectancy
Alzheimer Disease
5 Citations (Scopus)

The Neuroprotective Effects of Ratanasampil on Oxidative Stress-Mediated Neuronal Damage in Human Neuronal SH-SY5Y Cells

Zhu, A., Wu, Z., Meng, J., McGeer, P. L., Zhu, Y., Nakanishi, H. & Wu, S., Jan 1 2015, In : Oxidative medicine and cellular longevity. 2015, 792342.

Research output: Contribution to journalArticle

Oxidative stress
Neuroprotective Agents
Oxidative Stress
Tibetan Traditional Medicine
Phosphorylation
2014
7 Citations (Scopus)

Autophagy in superficial spinal dorsal horn accelerates the cathepsin b-dependent morphine antinociceptive tolerance

Hayashi, Y., Koga, Y., Zhang, X., Peters, C., Yanagawa, Y., Wu, Z., Yokoyama, T. & Nakanishi, H., Sep 5 2014, In : Neuroscience. 275, p. 384-394 11 p.

Research output: Contribution to journalArticle

Cathepsins
Autophagy
Morphine
Cathepsin B
Opioid Analgesics
25 Citations (Scopus)

Connection between periodontitis and Alzheimer's disease: Possible roles of microglia and leptomeningeal cells

Wu, Z. & Nakanishi, H., 2014, In : Journal of Pharmacological Sciences. 126, 1, p. 8-13 6 p.

Research output: Contribution to journalReview article

Periodontitis
Microglia
Alzheimer Disease
Chronic Periodontitis
Inflammation
23 Citations (Scopus)

Peripheral role of cathepsin S in Th1 cell-dependent transition of nerve injury-induced acute pain to a chronic pain state

Zhang, X., Wu, Z., Hayashi, Y., Okada, R. & Nakanishi, H., Feb 25 2014, In : Journal of Neuroscience. 34, 8, p. 3013-3022 10 p.

Research output: Contribution to journalArticle

cathepsin S
Th1 Cells
Acute Pain
Chronic Pain
Peripheral Nerve Injuries
2013
16 Citations (Scopus)

Brazilian green propolis suppresses the hypoxia-induced neuroinflammatory responses by inhibiting NF- B activation in microglia

Wu, Z., Zhu, A., Takayama, F., Okada, R., Liu, Y., Harada, Y., Wu, S. & Nakanishi, H., Sep 3 2013, In : Oxidative medicine and cellular longevity. 906726.

Research output: Contribution to journalArticle

Propolis
Microglia
Chemical activation
Interleukin-1
Interleukin-6
40 Citations (Scopus)

Differential pathways for interleukin-1β production activated by chromogranin A and amyloid β in microglia

Wu, Z., Sun, L., Hashioka, S., Yu, S., Schwab, C., Okada, R., Hayashi, Y., McGeer, P. L. & Nakanishi, H., Dec 1 2013, In : Neurobiology of Aging. 34, 12, p. 2715-2725 11 p.

Research output: Contribution to journalArticle

Chromogranin A
Microglia
Interleukin-1
Amyloid
Caspase 1
18 Citations (Scopus)

Leptomeningeal cells transduce peripheral macrophages inflammatory signal to microglia in reponse to Porphyromonas gingivalis LPS

Liu, Y., Wu, Z., Zhang, X., Ni, J., Yu, W., Zhou, Y. & Nakanishi, H., Dec 1 2013, In : Mediators of Inflammation. 2013, 407562.

Research output: Contribution to journalArticle

Porphyromonas gingivalis
Microglia
Macrophages
Interleukin-1
Chronic Periodontitis
2 Citations (Scopus)

Possible involvement of aiPLA2 in the phosphatidylserine-containing liposomes induced production of PGE2 and PGD2 in microglia

Takayama, F., Wu, Z., Ma, H. M., Okada, R., Hayashi, Y. & Nakanishi, H., Jul 12 2013, In : Journal of Neuroimmunology. 262, 1-2, p. 121-124 4 p.

Research output: Contribution to journalArticle

Prostaglandin D2
Phosphatidylserines
Microglia
Dinoprostone
Liposomes
49 Citations (Scopus)

The intrinsic microglial molecular clock controls synaptic strength via the circadian expression of cathepsin S

Hayashi, Y., Koyanagi, S., Kusunose, N., Okada, R., Wu, Z., Tozaki-Saitoh, H., Ukai, K., Kohsaka, S., Inoue, K., Ohdo, S. & Nakanishi, H., Oct 14 2013, In : Scientific reports. 3, 2744.

Research output: Contribution to journalArticle

cathepsin S
Microglia
Cats
Neurons
Spine

TNF-α signaling and cathepsin B

Wu, Z. & Nakanishi, H., Dec 1 2013, Tumor Necrosis Factor: Structure, Enzyme Regulation and Role in Health and Disease. Nova Science Publishers, Inc., p. 113-128 16 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Cathepsin B
Tumor Necrosis Factor-alpha
Innate Immunity
Inflammation
Apoptosis
2012
71 Citations (Scopus)

Age-dependent neuroinflammatory responses and deficits in long-term potentiation in the hippocampus during systemic inflammation

Liu, X., Take, H., Hayashi, Y. & Nakanishi, H., Aug 2 2012, In : Neuroscience. 216, p. 133-142 10 p.

Research output: Contribution to journalArticle

Long-Term Potentiation
Hippocampus
Inflammation
Experimental Arthritis
Microglia
35 Citations (Scopus)

Microglial cathepsin B contributes to the initiation of peripheral inflammation-induced chronic pain

Sun, L., Wu, Z., Hayashi, Y., Peters, C., Tsuda, M., Inoue, K. & Nakanishi, H., Aug 15 2012, In : Journal of Neuroscience. 32, 33, p. 11330-11342 13 p.

Research output: Contribution to journalArticle

Cathepsin B
Chronic Pain
Inflammation
Caspase 1
Interleukin-1

Multiple functions of osteoclasts and potential usefulness of phosphatidylserine-containing liposomes on bone diseases

Take, H. & Nakanishi, H., Sep 1 2012, Osteoclasts: Morphology, Functions and Clinical Implications. Nova Science Publishers, Inc., p. 131-141 11 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Bone Diseases
Phosphatidylserines
Osteoclasts
Liposomes
Bone
16 Citations (Scopus)

The role of microglial mtDNA damage in age-dependent prolonged LPS-induced sickness behavior

Nakanishi, H., Hayashi, Y. & Take, H., Jun 1 2012, In : Neuron Glia Biology. 7, 1, p. 17-23 7 p.

Research output: Contribution to journalArticle

Illness Behavior
Microglia
Mitochondrial DNA
DNA Damage
Lipopolysaccharides
2011

Cathepsin-dependent neuronal death pathways induced by methylmercury

Nakanishi, H. & Take, H., Feb 1 2011, Methylmercury: Formation, Sources and Health Effects. Nova Science Publishers, Inc., p. 81-95 15 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

methylmercury
nervous system
leakage
brain
inhibitor
17 Citations (Scopus)
Phosphatidylserines
Immune System Diseases
Phagocytes
Dinoprostone
Liposomes
23 Citations (Scopus)

Phosphatidylserine-containing liposomes suppress inflammatory bone loss by ameliorating the cytokine imbalance provoked by infiltrated macrophages

Ma, H. M., Wu, Z. & Nakanishi, H., Jun 1 2011, In : Laboratory Investigation. 91, 6, p. 921-931 11 p.

Research output: Contribution to journalArticle

Phosphatidylserines
Liposomes
Macrophages
Cytokines
Bone and Bones
2 Citations (Scopus)

Regulation of myeloid derived phagocytes by phosphatidylserine-containing liposomes: Possible involvement of prostaglandin E2 and the potential therapeutic application

Wu, Z. & Nakanishi, H., Jan 1 2011, Prostaglandins: Biochemistry, Functions, Types and Roles. Nova Science Publishers, Inc., p. 81-92 12 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Phosphatidylserines
Phagocytes
Dinoprostone
Liposomes
Cells
2010
35 Citations (Scopus)

Acute p38-mediated inhibition of NMDA-induced outward currents in hippocampal CA1 neurons by interleukin-1β

Zhang, R., Sun, L., Hayashi, Y., Liu, X., Koyama, S., Take, H. & Nakanishi, H., Apr 1 2010, In : Neurobiology of Disease. 38, 1, p. 68-77 10 p.

Research output: Contribution to journalArticle

Interleukin-1
Aspartic Acid
Neurons
Microglia
p38 Mitogen-Activated Protein Kinases
21 Citations (Scopus)

Cathepsin B-dependent motor neuron death after nerve injury in the adult mouse

Sun, L., Take, H., Baba, M., Peters, C., Uchiyama, Y. & Nakanishi, H., Aug 1 2010, In : Biochemical and Biophysical Research Communications. 399, 3, p. 391-395 5 p.

Research output: Contribution to journalArticle

Cathepsin B
Motor Neurons
Neurons
Wounds and Injuries
Noxae
56 Citations (Scopus)

Involvement of cathepsin B in the processing and secretion of interleukin-1β in chromogranin a-stimulated microglia

Terada, K., Yamada, J., Hayashi, Y., Wu, Z., Uchiyama, Y., Peters, C. & Nakanishi, H., Jan 8 2010, In : GLIA. 58, 1, p. 114-124 11 p.

Research output: Contribution to journalArticle

Chromogranins
Cathepsin B
Microglia
Interleukin-1
Interleukins
25 Citations (Scopus)

Phosphatidylserine-containing liposomes inhibit the differentiation of osteoclasts and trabecular bone loss

Take, H., Ma, H. M., Kukita, T., Nakanishi, Y. & Nakanishi, H., Mar 15 2010, In : Journal of Immunology. 184, 6, p. 3191-3201 11 p.

Research output: Contribution to journalArticle

Phosphatidylserines
Osteoclasts
Liposomes
Dinoprostone
Experimental Arthritis
2009
37 Citations (Scopus)

A possible suppressive role of galectin-3 in upregulated osteoclastogenesis accompanying adjuvant-induced arthritis in rats

Li, Y. J., Kukita, A., Teramachi, J., Nagata, K., Wu, Z., Akamine, A. & Kukita, T., Jan 1 2009, In : Laboratory Investigation. 89, 1, p. 26-37 12 p.

Research output: Contribution to journalArticle

Galectin 3
Experimental Arthritis
Osteogenesis
Osteoclasts
Bone and Bones
84 Citations (Scopus)

Microglia-aging: Roles of microglial lysosome- and mitochondria-derived reactive oxygen species in brain aging

Nakanishi, H. & Take, H., Jul 19 2009, In : Behavioural Brain Research. 201, 1, p. 1-7 7 p.

Research output: Contribution to journalReview article

Microglia
Lysosomes
Reactive Oxygen Species
Mitochondria
Brain
2008
34 Citations (Scopus)

Age-dependent responses of glial cells and leptomeninges during systemic inflammation

Take, H., Tokuda, Y., Zhang, X. W. & Nakanishi, H., Dec 1 2008, In : Neurobiology of Disease. 32, 3, p. 543-551 9 p.

Research output: Contribution to journalArticle

Occludin
Neuroglia
Experimental Arthritis
Inflammation
Transforming Growth Factors
28 Citations (Scopus)

Inhibition of NMDA-induced outward currents by interleukin-1β in hippocampal neurons

Zhang, R., Yamada, J., Hayashi, Y., Take, H., Koyama, S. & Nakanishi, H., Aug 8 2008, In : Biochemical and Biophysical Research Communications. 372, 4, p. 816-820 5 p.

Research output: Contribution to journalArticle

Induced currents
Interleukin-1
Aspartic Acid
Neurons
Charybdotoxin