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Research Output 2009 2019

  • 765 Citations
  • 17 h-Index
  • 26 Article
2019
3 Citations (Scopus)

Regenerating Corticospinal Axons Innervate Phenotypically Appropriate Neurons within Neural Stem Cell Grafts

Kumamaru, H., Lu, P., Rosenzweig, E. S., Kadoya, K. & Tuszynski, M. H., Feb 26 2019, In : Cell Reports. 26, 9, p. 2329-2339.e4

Research output: Contribution to journalArticle

Open Access
Neural Stem Cells
Stem cells
Grafts
Neurons
Axons
2018

Activation of Intrinsic Growth State Enhances Host Axonal Regeneration into Neural Progenitor Cell Grafts

Kumamaru, H., Lu, P., Rosenzweig, E. S. & Tuszynski, M. H., Oct 9 2018, In : Stem Cell Reports. 11, 4, p. 861-868 8 p.

Research output: Contribution to journalArticle

Grafts
Regeneration
Stem Cells
Chemical activation
Transplants
3 Citations (Scopus)

Adult rat myelin enhances axonal outgrowth from neural stem cells

Poplawski, G. H. D., Lie, R., Hunt, M., Kumamaru, H., Kawaguchi, R., Lu, P., Schäfer, M. K. E., Woodruff, G., Robinson, J., Canete, P., Dulin, J. N., Geoffroy, C. G., Menzel, L., Zheng, B., Coppola, G. & Tuszynski, M. H., May 23 2018, In : Science Translational Medicine. 10, 442, eaal2563.

Research output: Contribution to journalArticle

Neural Stem Cells
Myelin Sheath
Stem Cells
Axons
Spinal Cord Injuries
8 Citations (Scopus)

Generation and post-injury integration of human spinal cord neural stem cells

Kumamaru, H., Kadoya, K., Adler, A. F., Takashima, Y., Graham, L., Coppola, G. & Tuszynski, M. H., Sep 1 2018, In : Nature Methods. 15, 9, p. 723-731 9 p.

Research output: Contribution to journalArticle

Neural Stem Cells
Stem cells
Spinal Cord
Wounds and Injuries
Pluripotent Stem Cells
15 Citations (Scopus)

Injured adult motor and sensory axons regenerate into appropriate organotypic domains of neural progenitor grafts

Dulin, J. N., Adler, A. F., Kumamaru, H., Poplawski, G. H. D., Lee-Kubli, C., Strobl, H., Gibbs, D., Kadoya, K., Fawcett, J. W., Lu, P. & Tuszynski, M. H., Dec 1 2018, In : Nature communications. 9, 1, 84.

Research output: Contribution to journalArticle

axons
Grafts
Axons
Transplants
spinal cord
54 Citations (Scopus)

Restorative effects of human neural stem cell grafts on the primate spinal cord

Rosenzweig, E. S., Brock, J. H., Lu, P., Kumamaru, H., Salegio, E. A., Kadoya, K., Weber, J. L., Liang, J. J., Moseanko, R., Hawbecker, S., Huie, J. R., Havton, L. A., Nout-Lomas, Y. S., Ferguson, A. R., Beattie, M. S., Bresnahan, J. C. & Tuszynski, M. H., May 1 2018, In : Nature medicine. 24, 4, p. 484-490 7 p.

Research output: Contribution to journalArticle

Neural Stem Cells
Stem cells
Grafts
Primates
Spinal Cord
2017
17 Citations (Scopus)

Comprehensive Monosynaptic Rabies Virus Mapping of Host Connectivity with Neural Progenitor Grafts after Spinal Cord Injury

Adler, A. F., Lee-Kubli, C., Kumamaru, H., Kadoya, K. & Tuszynski, M. H., Jun 6 2017, In : Stem Cell Reports. 8, 6, p. 1525-1533 9 p.

Research output: Contribution to journalArticle

Rabies virus
Spinal Cord Injuries
Viruses
Grafts
Transplants
76 Citations (Scopus)

Interaction of reactive astrocytes with type i collagen induces astrocytic scar formation through the integrin-N-cadherin pathway after spinal cord injury

Hara, M., Kobayakawa, K., Ohkawa, Y., Kumamaru, H., Yokota, K., Saito, T., Kijima, K., Yoshizaki, S., Harimaya, K., Nakashima, Y. & Okada, S., Jul 1 2017, In : Nature medicine. 23, 7, p. 818-828 11 p.

Research output: Contribution to journalArticle

Cadherins
Spinal Cord Injuries
Integrins
Astrocytes
Cicatrix

Macrophage Infiltration Is a Causative Factor for Ligamentum Flavum Hypertrophy through the Activation of Collagen Production in Fibroblasts

Saito, T., Hara, M., Kumamaru, H., Kobayakawa, K., Yokota, K., Kijima, K., Yoshizaki, S., Harimaya, K., Matsumoto, Y., Kawaguchi, K., Hayashida, M., Inagaki, Y., Shiba, K., Nakashima, Y. & Okada, S., Dec 1 2017, In : American Journal of Pathology. 187, 12, p. 2831-2840 10 p.

Research output: Contribution to journalArticle

Ligamentum Flavum
Hypertrophy
Collagen
Fibroblasts
Macrophages
28 Citations (Scopus)

Prolonged human neural stem cell maturation supports recovery in injured rodent CNS

Lu, P., Ceto, S., Wang, Y., Graham, L., Wu, D., Kumamaru, H., Staufenberg, E. & Tuszynski, M. H., Sep 1 2017, In : Journal of Clinical Investigation. 127, 9, p. 3287-3299 13 p.

Research output: Contribution to journalArticle

Neural Stem Cells
Rodentia
Transplants
Spinal Cord Injuries
Astrocytes
20 Citations (Scopus)

Regulation of RhoA by STAT3 coordinates glial scar formation

Renault-Mihara, F., Mukaino, M., Shinozaki, M., Kumamaru, H., Kawase, S., Baudoux, M., Ishibashi, T., Kawabata, S., Nishiyama, Y., Sugai, K., Yasutake, K., Okada, S., Nakamura, M. & Okano, H., Jan 1 2017, In : Journal of Cell Biology. 216, 8, p. 2533-2550 18 p.

Research output: Contribution to journalArticle

STAT3 Transcription Factor
Neuroglia
Cicatrix
Astrocytes
Nestin
2016
91 Citations (Scopus)

Spinal cord reconstitution with homologous neural grafts enables robust corticospinal regeneration

Kadoya, K., Lu, P., Nguyen, K., Lee-Kubli, C., Kumamaru, H., Yao, L., Knackert, J., Poplawski, G., Dulin, J. N., Strobl, H., Takashima, Y., Biane, J., Conner, J., Zhang, S. C. & Tuszynski, M. H., May 1 2016, In : Nature medicine. 22, 5, p. 479-487 9 p.

Research output: Contribution to journalArticle

Grafts
Regeneration
Spinal Cord
Spinal Cord Injuries
Transplants
2014
21 Citations (Scopus)

Acute hyperglycemia impairs functional improvement after spinal cord injury in mice and humans

Kobayakawa, K., Kumamaru, H., Saiwai, H., Kubota, K., Ohkawa, Y., Kishimoto, J., Yokota, K., Ideta, R., Shiba, K., Tozaki-Saitoh, H., Inoue, K., Iwamoto, Y. & Okada, S., Oct 1 2014, In : Science Translational Medicine. 6, 256, 256ra137.

Research output: Contribution to journalArticle

Spinal Cord Injuries
Hyperglycemia
Obese Mice
Nervous System Trauma
Blood Glucose
2013
53 Citations (Scopus)

Ly6C+Ly6G- Myeloid-derived suppressor cells play a critical role in the resolution of acute inflammation and the subsequent tissue repair process after spinal cord injury

Saiwai, H., Kumamaru, H., Ohkawa, Y., Kubota, K., Kobayakawa, K., Yamada, H., Yokomizo, T., Iwamoto, Y. & Okada, S., Apr 1 2013, In : Journal of Neurochemistry. 125, 1, p. 74-88 15 p.

Research output: Contribution to journalArticle

Spinal Cord Injuries
Repair
Tissue
Inflammation
Neurology
34 Citations (Scopus)

Therapeutic activities of engrafted neural stem/precursor cells are not dormant in the chronically injured spinal cord

Kumamaru, H., Saiwai, H., Kubota, K., Kobayakawa, K., Yokota, K., Ohkawa, Y., Shiba, K., Iwamoto, Y. & Okada, S., Aug 1 2013, In : STEM CELLS. 31, 8, p. 1535-1547 13 p.

Research output: Contribution to journalArticle

Neural Stem Cells
Spinal Cord
Spinal Cord Injuries
Transplantation
Oligodendroglia
2012
26 Citations (Scopus)

Age-related differences in cellular and molecular profiles of inflammatory responses after spinal cord injury

Kumamaru, H., Saiwai, H., Ohkawa, Y., Yamada, H., Iwamoto, Y. & Okada, S., Apr 1 2012, In : Journal of Cellular Physiology. 227, 4, p. 1335-1346 12 p.

Research output: Contribution to journalArticle

Spinal Cord Injuries
Cytokines
Spinal Cord
Chemokines
Infiltration
65 Citations (Scopus)

Chd2 interacts with H3.3 to determine myogenic cell fate

Harada, A., Okada, S., Konno, D., Odawara, J., Yoshimi, T., Yoshimura, S., Kumamaru, H., Saiwai, H., Tsubota, T., Kurumizaka, H., Akashi, K., Tachibana, T., Imbalzano, A. N. & Ohkawa, Y., Jul 4 2012, In : EMBO Journal. 31, 13, p. 2994-3007 14 p.

Research output: Contribution to journalArticle

DNA Helicases
Genes
Cell Differentiation
Chromatin Assembly and Disassembly
Essential Genes
41 Citations (Scopus)

Direct isolation and RNA-seq reveal environment-dependent properties of engrafted neural stem/progenitor cells

Kumamaru, H., Ohkawa, Y., Saiwai, H., Yamada, H., Kubota, K., Kobayakawa, K., Akashi, K., Okano, H., Iwamoto, Y. & Okada, S., Nov 26 2012, In : Nature communications. 3, 1140.

Research output: Contribution to journalArticle

spinal cord injuries
transplantation
sequencing
Neural Stem Cells
stem cells
2 Citations (Scopus)

Extradural nodular fasciitis arising in the spinal canal

Kubota, K., Okada, S., Maeda, T., Matsumoto, Y., Sakamoto, A., Harimaya, K., Saiwai, H., Kumamaru, H., Oda, Y. & Iwamoto, Y., Jan 15 2012, In : Spine. 37, 2

Research output: Contribution to journalArticle

Fasciitis
Spinal Canal
Primitive Neuroectodermal Tumors
Ewing's Sarcoma
Neoplasms
25 Citations (Scopus)

Liposomal clodronate selectively eliminates microglia from primary astrocyte cultures

Kumamaru, H., Saiwai, H., Kobayakawa, K., Kubota, K., van Rooijen, N., Inoue, K., Iwamoto, Y. & Okada, S., May 31 2012, In : Journal of neuroinflammation. 9, 116.

Research output: Contribution to journalArticle

Clodronic Acid
Microglia
Astrocytes
Interleukin-6
Janus Kinases
29 Citations (Scopus)

Myeloperoxidase exacerbates secondary injury by generating highly reactive oxygen species and mediating neutrophil recruitment in experimental spinal cord injury

Kubota, K., Saiwai, H., Kumamaru, H., Maeda, T., Ohkawa, Y., Aratani, Y., Nagano, T., Iwamoto, Y. & Okada, S., Jul 15 2012, In : Spine. 37, 16, p. 1363-1369 7 p.

Research output: Contribution to journalArticle

Neutrophil Infiltration
Spinal Cord Injuries
Peroxidase
Reactive Oxygen Species
Wounds and Injuries
12 Citations (Scopus)

Neurological recovery is impaired by concurrent but not by asymptomatic pre-existing spinal cord compression after traumatic spinal cord injury

Kubota, K., Saiwai, H., Kumamaru, H., Kobayakawa, K., Maeda, T., Matsumoto, Y., Harimaya, K., Iwamoto, Y. & Okada, S., Aug 1 2012, In : Spine. 37, 17, p. 1448-1455 8 p.

Research output: Contribution to journalArticle

Spinal Stenosis
Spinal Cord Compression
Spinal Canal
Spinal Cord Injuries
Spinal Cord
2011
22 Citations (Scopus)

Flow cytometric sorting of neuronal and glial nuclei from central nervous system tissue

Okada, S., Saiwai, H., Kumamaru, H., Kubota, K., Harada, A., Yamaguchi, M., Iwamoto, Y. & Ohkawa, Y., Feb 1 2011, In : Journal of cellular physiology. 226, 2, p. 552-558 7 p.

Research output: Contribution to journalArticle

Nerve Tissue
Neurology
Sorting
Neuroglia
Nucleoproteins
2010
5 Citations (Scopus)

Production of a rat monoclonal antibody specific for Myf5

Harada, A., Okada, S., Odawara, J., Kumamaru, H., Saiwai, H., Aoki, M., Nakamura, M., Nishiyama, Y. & Ohkawa, Y., Feb 1 2010, In : Hybridoma. 29, 1, p. 59-62 4 p.

Research output: Contribution to journalArticle

Myogenic Regulatory Factors
Myoblasts
Monoclonal Antibodies
Helix-Loop-Helix Motifs
Myogenin
93 Citations (Scopus)

The LTB4-BLT1 axis mediates neutrophil infiltration and secondary injury in experimental spinal cord injury

Saiwai, H., Ohkawa, Y., Yamada, H., Kumamaru, H., Harada, A., Okano, H., Yokomizo, T., Iwamoto, Y. & Okada, S., Jan 1 2010, In : American Journal of Pathology. 176, 5, p. 2352-2366 15 p.

Research output: Contribution to journalArticle

Leukotriene B4
Neutrophil Infiltration
Spinal Cord Injuries
Leukotriene B4 Receptors
Leukocytes
2009
22 Citations (Scopus)

Does ossification of the posterior longitudinal ligament affect the neurological outcome after traumatic cervical cord injury?

Okada, S., Maeda, T., Ohkawa, Y., Harimaya, K., Saiwai, H., Kumamaru, H., Matsumoto, Y., Doi, T., Ueta, T., Shiba, K. & Iwamoto, Y., May 15 2009, In : Spine. 34, 11, p. 1148-1152 5 p.

Research output: Contribution to journalArticle

Ossification of Posterior Longitudinal Ligament
Nervous System
Wounds and Injuries
Spinal Cord Injuries
Spinal Injuries