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Research Output 1991 2019

2019
1 Citation (Scopus)

Analysis of sulfated glycosaminoglycans in ECM scaffolds for tissue engineering applications: Modified alcian blue method development and validation

Iimaa, T., Ikegami, Y., Bual, R., Shirakigawa, N. & Ijima, H., Jan 1 2019, In : Journal of Functional Biomaterials. 10, 2, 19.

Research output: Contribution to journalArticle

Open Access
A73025
Alcian Blue
Scaffolds (biology)
Tissue engineering
Heparin

A nano-sized gel-in-oil suspension for transcutaneous protein delivery

Hardiningtyas, S. D., Nagao, S., Yamamoto, E., Shirakigawa, N., Wakabayashi, R., Goto, M., Ijima, H. & Kamiya, N., Aug 15 2019, In : International Journal of Pharmaceutics. 567, 118495.

Research output: Contribution to journalArticle

Phycocyanin
Suspensions
Oils
Gels
Hydrogel

A novel evaluation system for whole-organ-engineered liver graft by ex vivo application to a highly reproducible hepatic failure rat model

Sakamoto, H., Shirakigawa, N., Bual, R. P., Fukuda, Y., Nakamura, S., Miyata, T., Yamao, T., Yamashita, Y. I., Baba, H. & Ijima, H., Sep 13 2019, In : Journal of Artificial Organs. 22, 3, p. 222-229 8 p.

Research output: Contribution to journalArticle

Liver Failure
Grafts
Liver
Rats
Transplants

Antibacterial-agent-immobilized gelatin hydrogel as a 3d scaffold for natural and bioengineered tissues

Iimaa, T., Hirayama, T., Shirakigawa, N., Imai, D., Yamao, T., Yamashita, Y. I., Baba, H. & Ijima, H., Jun 2019, In : Gels. 5, 2, 32.

Research output: Contribution to journalArticle

Open Access
Bactericides
Hydrogel
Gelatin
Hydrogels
Scaffolds
Nanofibers
Nerve Regeneration
Peripheral Nerves
Heparin
Intercellular Signaling Peptides and Proteins
Open Access
Liver
Extracellular Matrix
Rats
Hepatocytes
Maintenance
2 Citations (Scopus)

Liver-specific extracellular matrix hydrogel promotes liver-specific functions of hepatocytes in vitro and survival of transplanted hepatocytes in vivo

Ijima, H., Nakamura, S., Bual, R. P. & Yoshida, K., Sep 1 2019, In : Journal of Bioscience and Bioengineering. 128, 3, p. 365-372 8 p.

Research output: Contribution to journalArticle

Hydrogel
Hydrogels
Liver
Extracellular Matrix
Hepatocytes
2018

Current status and new challenges of the artificial liver

Mizumoto, H., Shirakigawa, N. & Ijima, H., Jun 27 2018, Biomedical Engineering Challenges: A Chemical Engineering Insight. Wiley-Blackwell, p. 27-54 28 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Decellularization of liver and organogenesis in rats

Shirakigawa, N. & Ijima, H., Jan 1 2018, Methods in Molecular Biology. Humana Press Inc., p. 271-281 11 p. (Methods in Molecular Biology; vol. 1577).

Research output: Chapter in Book/Report/Conference proceedingChapter

Organogenesis
Liver
Octoxynol
Blood Vessels
Hepatocytes
14 Citations (Scopus)

Decellularized Liver Matrix-Modified Cryogel Scaffolds as Potential Hepatocyte Carriers in Bioartificial Liver Support Systems and Implantable Liver Constructs

Damania, A., Kumar, A., Teotia, A. K., Kimura, H., Kamihira, M., Ijima, H., Sarin, S. K. & Kumar, A., Jan 10 2018, In : ACS Applied Materials and Interfaces. 10, 1, p. 114-126 13 p.

Research output: Contribution to journalArticle

Cryogels
Scaffolds (biology)
Liver
Bioreactors
Tissue engineering
2 Citations (Scopus)

Fabrication of liver-derived extracellular matrix nanofibers and functional evaluation in in vitro culture using primary hepatocytes

Bual, R., Kimura, H., Ikegami, Y., Shirakigawa, N. & Ijima, H., Dec 1 2018, In : Materialia. 4, p. 518-528 11 p.

Research output: Contribution to journalArticle

Nanofibers
Liver
Military electronic countermeasures
Scaffolds (biology)
Fabrication
2017
6 Citations (Scopus)

Alleviating liver failure conditions using an integrated hybrid cryogel based cellular bioreactor as a bioartificial liver support

Kumar, A., Damania, A., Hassan, M., Shirakigawa, N., Mizumoto, H., Kumar, A., Sarin, S. K., Ijima, H. & Kamihira, M., Jan 12 2017, In : Scientific reports. 7, 40323.

Research output: Contribution to journalArticle

Cryogels
Artificial Liver
Liver Failure
Bioreactors
Plasmapheresis
2 Citations (Scopus)

Decellularized tissue engineering

Shirakigawa, N. & Ijima, H., Jan 1 2017, Advanced Structured Materials. Springer Verlag, p. 185-226 42 p. (Advanced Structured Materials; vol. 66).

Research output: Chapter in Book/Report/Conference proceedingChapter

Tissue engineering
Tissue
Scaffolds (biology)
Cytokines
3 Citations (Scopus)

Development of an in situ evaluation system for neural cells using extracellular matrix-modeled gel culture

Nagai, T., Ikegami, Y., Mizumachi, H., Shirakigawa, N. & Ijima, H., Oct 1 2017, In : Journal of Bioscience and Bioengineering. 124, 4, p. 430-438 9 p.

Research output: Contribution to journalArticle

Cell culture
Extracellular Matrix
Gels
Hydrogel
Collagen
2016
1 Citation (Scopus)

Fetal liver cell-containing hybrid organoids improve cell viability and albumin production upon transplantation

Ye, J., Shirakigawa, N. & Ijima, H., Jun 1 2016, In : Journal of Bioscience and Bioengineering. 121, 6, p. 701-708 8 p.

Research output: Contribution to journalArticle

Organoids
Hybrid Cells
Liver
Albumins
Cell Survival
2015
4 Citations (Scopus)

Hybrid organoids consisting of extracellular matrix gel particles and hepatocytes for transplantation

Ye, J., Shirakigawa, N. & Ijima, H., Aug 1 2015, In : Journal of Bioscience and Bioengineering. 120, 2, p. 231-237 7 p.

Research output: Contribution to journalArticle

Organoids
Particles (particulate matter)
Extracellular Matrix
Hepatocytes
Gels
2014
15 Citations (Scopus)

Micropatterning electrospun scaffolds to create intrinsic vascular networks

Jeffries, E. M., Nakamura, S., Lee, K. W., Clampffer, J., Ijima, H. & Wang, Y., Nov 1 2014, In : Macromolecular Bioscience. 14, 11, p. 1514-1520 7 p.

Research output: Contribution to journalArticle

Scaffolds
Blood Vessels
Perfusion
Porosity
Tissue
Military electronic countermeasures
Liver
Molecular structure
Collagen
Adhesives
2013
25 Citations (Scopus)

Base structure consisting of an endothelialized vascular-tree network and hepatocytes for whole liver engineering

Shirakigawa, N., Takei, T. & Ijima, H., Dec 1 2013, In : Journal of Bioscience and Bioengineering. 116, 6, p. 740-745 6 p.

Research output: Contribution to journalArticle

Liver
Blood Vessels
Hepatocytes
Artificial Liver
Hepatic Veins
17 Citations (Scopus)

Heparin-conjugated gelatin as a growth factor immobilization scaffold

Nakamura, S., Kubo, T. & Ijima, H., May 1 2013, In : Journal of Bioscience and Bioengineering. 115, 5, p. 562-567 6 p.

Research output: Contribution to journalArticle

Gelatin
Scaffolds (biology)
Immobilization
Heparin
Intercellular Signaling Peptides and Proteins
1 Citation (Scopus)

Nucleus number in clusters of transplanted fetal liver cells increases by partial hepatectomy of recipient rats

Shirakigawa, N. & Ijima, H., May 1 2013, In : Journal of Bioscience and Bioengineering. 115, 5, p. 568-570 3 p.

Research output: Contribution to journalArticle

Hepatectomy
Liver
Rats
Tissue
Hydrogel
25 Citations (Scopus)
Military electronic countermeasures
Scaffolds (biology)
Liver
Hepatocyte Growth Factor
Hepatocytes
2012
12 Citations (Scopus)

A comparison of sodium sulfate, sodium phosphate, and boric acid for preparation of immobilized Pseudomonas putida F1 in poly(vinyl alcohol) beads

Takei, T., Ikeda, K., Ijima, H., Yoshida, M. & Kawakami, K., Jul 1 2012, In : Polymer Bulletin. 69, 3, p. 363-373 11 p.

Research output: Contribution to journalArticle

boric acids
Boric acid
Sodium sulfate
pseudomonas
sodium sulfates
45 Citations (Scopus)

Decellularized liver as a practical scaffold with a vascular network template for liver tissue engineering

Shirakigawa, N., Ijima, H. & Takei, T., Nov 1 2012, In : Journal of Bioscience and Bioengineering. 114, 5, p. 546-551 6 p.

Research output: Contribution to journalArticle

Tissue Engineering
Scaffolds (biology)
Tissue engineering
Liver
Blood Vessels
6 Citations (Scopus)

Development of growth factor-immobilizable material for hepatocyte transplantation

Hou, Y. T., Ijima, H., Shirakigawa, N., Takei, T. & Kawakami, K., Dec 15 2012, In : Biochemical Engineering Journal. 69, p. 172-181 10 p.

Research output: Contribution to journalArticle

Hepatocytes
Intercellular Signaling Peptides and Proteins
Transplantation
Heparin
Collagen
12 Citations (Scopus)

Evaluation of a hybrid artificial liver module based on a spheroid culture system of embryonic stem cell-derived hepatic cells

Mizumoto, H., Hayashi, S., Matsumoto, K., Ikeda, K., Kusumi, T., Inamori, M., Nakazawa, K., Ijima, H., Funatsu, K. & Kajiwara, T., Apr 18 2012, In : Cell Transplantation. 21, 2-3, p. 421-428 8 p.

Research output: Contribution to journalArticle

Artificial Liver
Embryonic Stem Cells
Stem cells
Cell culture
Liver
7 Citations (Scopus)

Fabrication of capillary-like network in a matrix of water-soluble polymer using poly(methyl methacrylate) microfibers

Takei, T., Kishihara, N., Ijima, H. & Kawakami, K., Feb 1 2012, In : Artificial Cells, Blood Substitutes, and Biotechnology. 40, 1-2, p. 66-69 4 p.

Research output: Contribution to journalArticle

Polymethyl Methacrylate
Polymethyl methacrylates
Polymers
Gels
Fabrication
51 Citations (Scopus)

Synthesis of a chitosan derivative soluble at neutral pH and gellable by freeze-thawing, and its application in wound care

Takei, T., Nakahara, H., Ijima, H. & Kawakami, K., Feb 1 2012, In : Acta Biomaterialia. 8, 2, p. 686-693 8 p.

Research output: Contribution to journalArticle

Thawing
Chitosan
Derivatives
Wounds and Injuries
Hydrogels
2011
3 Citations (Scopus)
Organoids
Artificial Liver
Liver
Hepatocytes
Equipment and Supplies
60 Citations (Scopus)

Fabrication of poly(vinyl alcohol) hydrogel beads crosslinked using sodium sulfate for microorganism immobilization

Takei, T., Ikeda, K., Ijima, H. & Kawakami, K., Feb 1 2011, In : Process Biochemistry. 46, 2, p. 566-571 6 p.

Research output: Contribution to journalArticle

Boric acid
Sodium sulfate
Hydrogel
Hydrogels
Immobilization
31 Citations (Scopus)

Growth factor/heparin-immobilized collagen gel system enhances viability of transplanted hepatocytes and induces angiogenesis

Hou, Y. T., Ijima, H., Takei, T. & Kawakami, K., Sep 1 2011, In : Journal of Bioscience and Bioengineering. 112, 3, p. 265-272 8 p.

Research output: Contribution to journalArticle

Collagen
Heparin
Hepatocytes
Intercellular Signaling Peptides and Proteins
Gels
15 Citations (Scopus)

Hepatic differentiation of mouse embryonic stem cells and induced pluripotent stem cells during organoid formation in hollow fibers

Amimoto, N., Mizumoto, H., Nakazawa, K., Ijima, H., Funatsu, K. & Kajiwara, T., Aug 1 2011, In : Tissue Engineering - Part A. 17, 15-16, p. 2071-2078 8 p.

Research output: Contribution to journalArticle

Organoids
Induced Pluripotent Stem Cells
Stem cells
Artificial Liver
Fibers
20 Citations (Scopus)

In situ gellable sugar beet pectin via enzyme-catalyzed coupling reaction of feruloyl groups for biomedical applications

Takei, T., Sugihara, K., Ijima, H. & Kawakami, K., Nov 1 2011, In : Journal of Bioscience and Bioengineering. 112, 5, p. 491-494 4 p.

Research output: Contribution to journalArticle

Sugar beets
Beta vulgaris
Enzymes
Horseradish Peroxidase
Gels
2010
4 Citations (Scopus)

Albumin production activity of primary rat hepatocytes is improved on type V collagen

Ijima, H., Ogata, R., Murasawa, Y. & Wang, P. C., Feb 1 2010, In : Journal of Bioscience and Bioengineering. 109, 2, p. 179-181 3 p.

Research output: Contribution to journalArticle

Collagen Type V
Collagen
Rats
Hepatocytes
Albumins
8 Citations (Scopus)

Development of hepatocyte-embedded hydrogel-filled macroporous scaffold cultures using transglutaminase

Ijima, H., Hou, Y. T. & Takei, T., Nov 15 2010, In : Biochemical Engineering Journal. 52, 2-3, p. 276-281 6 p.

Research output: Contribution to journalArticle

Transglutaminases
Hydrogel
Hydrogels
Scaffolds
Hepatocytes
27 Citations (Scopus)

Effect of a hepatocyte growth factor/heparin-immobilized collagen system on albumin synthesis and spheroid formation by hepatocytes

Hou, Y. T., Ijima, H., Matsumoto, S., Kubo, T., Takei, T., Sakai, S. & Kawakami, K., Aug 1 2010, In : Journal of Bioscience and Bioengineering. 110, 2, p. 208-216 9 p.

Research output: Contribution to journalArticle

Hepatocyte Growth Factor
Collagen
Heparin
Hepatocytes
Albumins
41 Citations (Scopus)

In situ gellable oxidized citrus pectin for localized delivery of anticancer drugs and prevention of homotypic cancer cell aaggregation

Takei, T., Sato, M., Ijima, H. & Kawakami, K., Dec 13 2010, In : Biomacromolecules. 11, 12, p. 3525-3530 6 p.

Research output: Contribution to journalArticle

Hydrogels
Cells
Doxorubicin
Pharmaceutical Preparations
Drug delivery
14 Citations (Scopus)

Practical and functional culture technologies for primary hepatocytes

Ijima, H., Feb 15 2010, In : Biochemical Engineering Journal. 48, 3, p. 332-336 5 p.

Research output: Contribution to journalReview article

Organoids
Liver
Hepatocytes
Technology
Metabolism
14 Citations (Scopus)
Photopolymerization
Alginate
Capsules
Irradiation
Light
20 Citations (Scopus)

Preparation of polymeric microcapsules enclosing microbial cells by radical suspension polymerization via water-in-oil-in-water emulsion

Takei, T., Ikeda, K., Ijima, H., Kawakami, K., Yoshida, M. & Hatate, Y., Jul 1 2010, In : Polymer Bulletin. 65, 3, p. 283-291 9 p.

Research output: Contribution to journalArticle

Emulsions
Yeast
emulsions
Capsules
Suspensions
2009
10 Citations (Scopus)
Coculture Techniques
Collagen
Culture Media
Rats
Hepatocytes
2 Citations (Scopus)

Development of a practical small-scale circulation bioreactor and application to a drug metabolism simulator

Ijima, H., Kakeya, Y., Ogata, T. & Sakai, T., May 15 2009, In : Biochemical Engineering Journal. 44, 2-3, p. 292-296 5 p.

Research output: Contribution to journalArticle

Bioreactors
Metabolism
Simulators
Hepatocytes
Lidocaine
7 Citations (Scopus)

Evaluation of a bioreactor with stacked sheet shaped organoids of primary hepatocytes

Kusumi, T., Ishihara, K., Mizumoto, H., Nakazawa, K., Ijima, H., Funatsu, K. & Kajiwara, T., May 1 2009, In : Journal of Bioscience and Bioengineering. 107, 5, p. 552-555 4 p.

Research output: Contribution to journalArticle

Organoids
Bioreactors
Hepatocytes
Oxygen supply
polycarbonate
12 Citations (Scopus)
Hepatocyte Growth Factor
Epidermal Growth Factor
Polyurethanes
Foams
Hepatocytes
13 Citations (Scopus)

Magnetic separation of cells in coculture systems using magnetite cationic liposomes.

Ito, A., Jitsunobu, H., Yoshinori, K., Ijima, H. & Kamihira, M., Jan 1 2009, In : Tissue engineering. Part C, Methods. 15, 3, p. 413-423 11 p.

Research output: Contribution to journalArticle

Ferrosoferric Oxide
Magnetic separation
Cell Separation
Liposomes
Magnetite
16 Citations (Scopus)
Hepatocyte Growth Factor
Collagen
Heparin
Rats
Hepatocytes
2008
24 Citations (Scopus)

A new culture technique for hepatocyte organoid formation and long-term maintenance of liver-specific functions

Mizumoto, H., Ishihara, K., Nakazawa, K., Ijima, H., Funatsu, K. & Kajiwara, T., Jan 1 2008, In : Tissue Engineering - Part C: Methods. 14, 2, p. 167-175 9 p.

Research output: Contribution to journalArticle

Organoids
Culture Techniques
Liver
Hepatocytes
Artificial Liver
11 Citations (Scopus)
Cadherins
Fibroblasts
Cell Communication
Hepatocytes
Cell adhesion

Formation of Co-cultured hepatocyte spheroid which aimed at liver tissue engineering, and preliminary study for the device

Ijima, H., Kakeya, Y., Ogata, R., Hou, Y. T., Kubo, T., Sakai, S. & Kawakami, K., Dec 1 2008, 8th World Biomaterials Congress 2008. 1 p. (8th World Biomaterials Congress 2008; vol. 3).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Tissue engineering
Liver
Hepatocytes
18 Citations (Scopus)

Hepatic Differentiation of Embryonic Stem Cells in HF/Organoid Culture

Mizumoto, H., Aoki, K., Nakazawa, K., Ijima, H., Funatsu, K. & Kajiwara, T., Mar 1 2008, In : Transplantation Proceedings. 40, 2, p. 611-613 3 p.

Research output: Contribution to journalArticle

Organoids
Embryonic Stem Cells
Liver
Hepatocytes
Macaca fascicularis