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2019

Logical design of oral glucose ingestion pattern minimizing blood glucose in humans

Fujii, M., Murakami, Y., Karasawa, Y., Sumitomo, Y., Fujita, S., Koyama, M., Uda, S., Kubota, H., Inoue, H., Konishi, K., Oba, S., Ishii, S. & Kuroda, S., Dec 1 2019, In : npj Systems Biology and Applications. 5, 1, 31.

Research output: Contribution to journalArticle

Open Access

Reconstruction of global regulatory network from signaling to cellular functions using phosphoproteomic data

Kawata, K., Yugi, K., Hatano, A., Kokaji, T., Tomizawa, Y., Fujii, M., Uda, S., Kubota, H., Matsumoto, M., Nakayama, K. I. & Kuroda, S., Jan 2019, In : Genes to Cells. 24, 1, p. 82-93 12 p.

Research output: Contribution to journalArticle

Trans-omics Impact of Thymoproteasome in Cortical Thymic Epithelial Cells

Ohigashi, I., Tanaka, Y., Kondo, K., Fujimori, S., Kondo, H., Palin, A. C., Hoffmann, V., Kozai, M., Matsushita, Y., Uda, S., Motosugi, R., Hamazaki, J., Kubota, H., Murata, S., Tanaka, K., Katagiri, T., Kosako, H. & Takahama, Y., Nov 26 2019, In : Cell Reports. 29, 9, p. 2901-2916.e6

Research output: Contribution to journalArticle

Open Access
5 Citations (Scopus)
2018

Increase in hepatic and decrease in peripheral insulin clearance characterize abnormal temporal patterns of serum insulin in diabetic subjects

Ohashi, K., Fujii, M., Uda, S., Kubota, H., Komada, H., Sakaguchi, K., Ogawa, W. & Kuroda, S., 2018, In : npj Systems Biology and Applications. 4, 14.

Research output: Contribution to journalArticle

Open Access

Increase in hepatic and decrease in peripheral insulin clearance characterize abnormal temporal patterns of serum insulin in diabetic subjects

Ohashi, K., Fujii, M., Uda, S., Kubota, H., Komada, H., Sakaguchi, K., Ogawa, W. & Kuroda, S., Dec 1 2018, In : npj Systems Biology and Applications. 4, 1, 14.

Research output: Contribution to journalArticle

6 Citations (Scopus)

In Vivo Decoding Mechanisms of the Temporal Patterns of Blood Insulin by the Insulin-AKT Pathway in the Liver

Kubota, H., Uda, S., Matsuzaki, F., Yamauchi, Y. & Kuroda, S., Jul 25 2018, In : Cell Systems. 7, 1, p. 118-128.e3

Research output: Contribution to journalArticle

5 Citations (Scopus)

Trans-omic Analysis Reveals Selective Responses to Induced and Basal Insulin across Signaling, Transcriptional, and Metabolic Networks

Kawata, K., Hatano, A., Yugi, K., Kubota, H., Sano, T., Fujii, M., Tomizawa, Y., Kokaji, T., Tanaka, K. Y., Uda, S., Suzuki, Y., Matsumoto, M., Nakayama, K. I., Saitoh, K., Kato, K., Ueno, A., Ohishi, M., Hirayama, A., Soga, T. & Kuroda, S., Sep 28 2018, In : iScience. 7, p. 212-229 18 p.

Research output: Contribution to journalArticle

Open Access
8 Citations (Scopus)
2017

System identification of signaling dependent gene expression with different time-scale data

Tsuchiya, T., Fujii, M., Matsuda, N., Kunida, K., Uda, S., Kubota, H., Konishi, K. & Kuroda, S., Dec 2017, In : PLoS Computational Biology. 13, 12, e1005913.

Research output: Contribution to journalArticle

3 Citations (Scopus)
2016

Reversible interconversion and maintenance of mammary epithelial cell characteristics by the ligand-regulated EGFR system

Fukuda, S., Nishida-Fukuda, H., Nanba, D., Nakashiro, K. I., Nakayama, H., Kubota, H. & Higashiyama, S., Feb 2 2016, In : Scientific reports. 6, 20209.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Selective control of up-regulated and down-regulated genes by temporal patterns and doses of insulin

Sano, T., Kawata, K., Ohno, S., Yugi, K., Kakuda, H., Kubota, H., Uda, S., Fujii, M., Kunida, K., Hoshino, D., Hatano, A., Ito, Y., Sato, M., Suzuki, Y. & Kuroda, S., Nov 22 2016, In : Science Signaling. 9, 455, ra112.

Research output: Contribution to journalArticle

7 Citations (Scopus)
2015

An optogenetic system for interrogating the temporal dynamics of Akt

Katsura, Y., Kubota, H., Kunida, K., Kanno, A., Kuroda, S. & Ozawa, T., Oct 1 2015, In : Scientific reports. 5, 14589.

Research output: Contribution to journalArticle

30 Citations (Scopus)

Glucose homeostatic law: Insulin clearance predicts the progression of glucose intolerance in humans

Ohashi, K., Komada, H., Uda, S., Kubota, H., Iwaki, T., Fukuzawa, H., Komori, Y., Fujii, M., Toyoshima, Y., Sakaguchi, K., Ogawa, W. & Kuroda, S., Dec 1 2015, In : PloS one. 10, 12, A38.

Research output: Contribution to journalArticle

12 Citations (Scopus)
2014

Reconstruction of insulin signal flow from phosphoproteome and metabolome data

Yugi, K., Kubota, H., Toyoshima, Y., Noguchi, R., Kawata, K., Komori, Y., Uda, S., Kunida, K., Tomizawa, Y., Funato, Y., Miki, H., Matsumoto, M., Nakayama, K. I., Kashikura, K., Endo, K., Ikeda, K., Soga, T. & Kuroda, S., Aug 21 2014, In : Cell Reports. 8, 4, p. 1171-1183 13 p.

Research output: Contribution to journalArticle

40 Citations (Scopus)
2013

Robustness and compensation of information transmission of signaling pathways

Uda, S., Saito, T. H., Kudo, T., Kokaji, T., Tsuchiya, T., Kubota, H., Komori, Y., Ozaki, Y. I. & Kuroda, S., Jan 1 2013, In : Science. 341, 6145, p. 558-561 4 p.

Research output: Contribution to journalArticle

67 Citations (Scopus)

The Extraction of Simple Relationships in Growth Factor-Specific Multiple-Input and Multiple-Output Systems in Cell-Fate Decisions by Backward Elimination PLS Regression

Akimoto, Y., Yugi, K., Uda, S., Kudo, T., Komori, Y., Kubota, H. & Kuroda, S., Sep 9 2013, In : PloS one. 8, 9, e72780.

Research output: Contribution to journalArticle

3 Citations (Scopus)

The selective control of glycolysis, gluconeogenesis and glycogenesis by temporal insulin patterns

Noguchi, R., Kubota, H., Yugi, K., Toyoshima, Y., Komori, Y., Soga, T. & Kuroda, S., Jan 1 2013, In : Molecular Systems Biology. 9, 1, 664.

Research output: Contribution to journalArticle

29 Citations (Scopus)
2012

Temporal Coding of Insulin Action through Multiplexing of the AKT Pathway

Kubota, H., Noguchi, R., Toyoshima, Y., Ozaki, Y. I., Uda, S., Watanabe, K., Ogawa, W. & Kuroda, S., Jun 29 2012, In : Molecular Cell. 46, 6, p. 820-832 13 p.

Research output: Contribution to journalArticle

67 Citations (Scopus)
2010

A quantitative image cytometry technique for time series or population analyses of signaling networks

Ozaki, Y. I., Uda, S., Saito, T. H., Chung, J., Kubota, H. & Kuroda, S., 2010, In : PloS one. 5, 4, e9955.

Research output: Contribution to journalArticle

26 Citations (Scopus)

Decoupling of receptor and downstream signals in the Akt pathway by its low-pass filter characteristics

Fujita, K. A., Toyoshima, Y., Uda, S., Ozaki, Y. I., Kubota, H. & Kuroda, S., Jul 27 2010, In : Science Signaling. 3, 132, p. ra56

Research output: Contribution to journalArticle

45 Citations (Scopus)

Timing-dependent actions of NGF required for cell differentiation

Chung, J., Kubota, H., Ozaki, Y. I., Uda, S. & Kuroda, S., Feb 2 2010, In : PloS one. 5, 2, e9011.

Research output: Contribution to journalArticle

35 Citations (Scopus)
2005

The yeast eIF4E-associated protein Eap1p attenuates GCN4 translation upon TOR-inactivation

Matsuo, R., Kubota, H., Obata, T., Kito, K., Ota, K., Kitazono, T., Ibayashi, S., Sasaki, T., Iida, M. & Ito, T., Apr 25 2005, In : FEBS Letters. 579, 11, p. 2433-2438 6 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)
2004

Transcriptomic and proteomic analysis of a 14-3-3 gene-deficient yeast

Ichimura, T., Kubota, H., Goma, T., Mizushima, N., Ohsumi, Y., Iwago, M., Kakiuchi, K., Shekhar, H. U., Shinkawa, T., Taoka, M., Ito, T. & Isobe, T., May 25 2004, In : Biochemistry. 43, 20, p. 6149-6158 10 p.

Research output: Contribution to journalArticle

34 Citations (Scopus)
2003

Rapamycin-induced translational derepression of GCN4 mRNA involves a novel mechanism for activation of the eIF2α kinase GCN2

Kubota, H., Obata, T., Ota, K., Sasaki, T. & Ito, T., Jun 6 2003, In : Journal of Biological Chemistry. 278, 23, p. 20457-20460 4 p.

Research output: Contribution to journalArticle

80 Citations (Scopus)
2001

Budding Yeast GCN1 Binds the GI Domain to Activate the eIF2α Kinase GCN2

Kubota, H., Ota, K., Sakaki, Y. & Ito, T., May 18 2001, In : Journal of Biological Chemistry. 276, 20, p. 17591-17596 6 p.

Research output: Contribution to journalArticle

38 Citations (Scopus)
2000
41 Citations (Scopus)