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Research Output 1988 2019

2019
3 Citations (Scopus)

Clinical Pharmacokinetics of Anaplastic Lymphoma Kinase Inhibitors in Non-Small-Cell Lung Cancer

Hirota, T., Muraki, S. & Ieiri, I., Apr 4 2019, In : Clinical Pharmacokinetics. 58, 4, p. 403-420 18 p.

Research output: Contribution to journalReview article

Non-Small Cell Lung Carcinoma
Pharmacokinetics
Pharmaceutical Preparations
Cytochrome P-450 Enzyme System
Cytochrome P-450 CYP3A
3 Citations (Scopus)

Effect of OATP1B1 genotypes on plasma concentrations of endogenous OATP1B1 substrates and drugs, and their association in healthy volunteers

Mori, D., Kashihara, Y., Yoshikado, T., Kimura, M., Hirota, T., Matsuki, S., Maeda, K., Irie, S., Ieiri, I., Sugiyama, Y. & Kusuhara, H., Feb 1 2019, In : Drug metabolism and pharmacokinetics. 34, 1, p. 78-86 9 p.

Research output: Contribution to journalArticle

Sulfates
Healthy Volunteers
Genotype
fluvastatin
Pharmaceutical Preparations

Effects of magnesium oxide on pharmacokinetics of L-dopa/carbidopa and assessment of pharmacodynamic changes by a model-based simulation

Kashihara, Y., Terao, Y., Yoda, K., Hirota, T., Kubota, T., Kimura, M., Matsuki, S., Hirakawa, M., Irie, S. & Ieiri, I., Mar 6 2019, In : European Journal of Clinical Pharmacology. 75, 3, p. 351-361 11 p.

Research output: Contribution to journalArticle

Magnesium Oxide
Carbidopa
Levodopa
Pharmacokinetics
Meta-Analysis
2 Citations (Scopus)

Efficacy of DPP-4 inhibitors, GLP-1 analogues, and SGLT2 inhibitors as add-ons to metformin monotherapy in T2DM patients: a model-based meta-analysis

Inoue, H., Tamaki, Y., Kashihara, Y., Muraki, S., Kakara, M., Hirota, T. & Ieiri, I., Feb 1 2019, In : British journal of clinical pharmacology. 85, 2, p. 393-402 10 p.

Research output: Contribution to journalArticle

Glucagon-Like Peptide 1
Metformin
Hypoglycemic Agents
Type 2 Diabetes Mellitus
Meta-Analysis
2 Citations (Scopus)

Identification of drug transporters contributing to oxaliplatin-induced peripheral neuropathy

Fujita, S., Hirota, T., Sakiyama, R., Baba, M. & Ieiri, I., Feb 1 2019, In : Journal of Neurochemistry. 148, 3, p. 373-385 13 p.

Research output: Contribution to journalArticle

oxaliplatin
Peripheral Nervous System Diseases
Spinal Ganglia
Platinum
Pharmaceutical Preparations

Pharmacokinetics, Pharmacodynamics, and Safety of E6011, a Novel Humanized Antifractalkine (CX3CL1) Monoclonal Antibody: A Randomized, Double-Blind, Placebo-Controlled Single-Ascending-Dose Study

Tabuchi, H., Katsurabara, T., Mori, M., Aoyama, M., Obara, T., Yasuda, N., Kawano, T., Imai, T., Ieiri, I. & Kumagai, Y., May 1 2019, In : Journal of Clinical Pharmacology. 59, 5, p. 688-701 14 p.

Research output: Contribution to journalArticle

Pharmacokinetics
Monoclonal Antibodies
Placebos
Safety
Serum

The association of tobacco use with prescription of muscle relaxants, benzodiazepines, and opioid analgesics for non-cancer pain

Takaki, H., Ieiri, I., Shibuta, H., Onozuka, D. & Hagihara, A., Jan 9 2019, In : American Journal on Addictions.

Research output: Contribution to journalArticle

Tobacco Use
Benzodiazepines
Opioid Analgesics
Prescriptions
Pain
2018
1 Citation (Scopus)

Characterization of changes in HbA1c in patients with and without secondary failure after metformin treatments by a population pharmacodynamic analysis using mixture models

Tamaki, Y., Maema, K., Kakara, M., Fukae, M., Kinoshita, R., Kashihara, Y., Muraki, S., Hirota, T. & Ieiri, I., Dec 1 2018, In : Drug metabolism and pharmacokinetics. 33, 6, p. 264-269 6 p.

Research output: Contribution to journalArticle

Metformin
Population
Therapeutics
Electronic Health Records
Glycosylated Hemoglobin A
3 Citations (Scopus)
CpG Islands
Human Activities
Methylation
Skin
Messenger RNA
1 Citation (Scopus)

Nucleosome positioning and gene regulation of the SGLT2 gene in the renal proximal tubular epithelial cells

Takesue, H., Hirota, T., Tachimura, M., Tokashiki, A. & Ieiri, I., Sep 1 2018, In : Molecular Pharmacology. 94, 3, p. 953-962 10 p.

Research output: Contribution to journalArticle

Sodium-Glucose Transport Proteins
Nucleosomes
Epithelial Cells
Kidney
Genes

Population Pharmacodynamic Analysis of Uric Acid–Lowering Effects of Febuxostat Based on Electronic Medical Records in Two Hospitals

Muraki, S., Moriki, K., Shigematsu, S., Fukae, M., Kakara, M., Yamashita, D., Hirota, T., Takane, H., Shimada, M., Hirakawa, M. & Ieiri, I., Mar 1 2018, In : Journal of Clinical Pharmacology. 58, 3, p. 304-313 10 p.

Research output: Contribution to journalArticle

Electronic Health Records
Uric Acid
Population
Blood Urea Nitrogen
Urban Hospitals

Population Pharmacokinetics and Pharmacodynamics of Oral Propranolol in Pediatric Patients With Infantile Hemangioma

Takechi, T., Kumokawa, T., Kato, R., Higuchi, T., Kaneko, T. & Ieiri, I., Oct 1 2018, In : Journal of Clinical Pharmacology. 58, 10, p. 1361-1370 10 p.

Research output: Contribution to journalArticle

Hemangioma
Propranolol
Pharmacokinetics
Pediatrics
Population

Psychological assessment of acute schizophrenia patients who experienced seclusion either alone or in combination with restraint

Eguchi, R., Onozuka, D., Ikeda, K., Kuroda, K., Ieiri, I. & Hagihara, A., May 1 2018, In : International Journal of Psychiatry in Medicine. 53, 3, p. 171-188 18 p.

Research output: Contribution to journalArticle

Schizophrenia
Psychiatry
Psychology
Brief Psychiatric Rating Scale
Hostility
2 Citations (Scopus)
CpG Islands
DNA Methylation
Liver
Proteins
Messenger RNA
2 Citations (Scopus)
Intravenous Administration
Nanoparticles
Pharmacokinetics
Placebos
Research Personnel
1 Citation (Scopus)

The relationship between fine particulate matter (PM) and schizophrenia severity

Eguchi, R., Onozuka, D., Ikeda, K., Kuroda, K., Ieiri, I. & Hagihara, A., Apr 23 2018, In : International Archives of Occupational and Environmental Health.

Research output: Contribution to journalArticle

Particulate Matter
Schizophrenia
Brief Psychiatric Rating Scale
Patient Admission
Air Pollution
2017
7 Citations (Scopus)

Characterization of ADME gene variation in 21 populations by exome sequencing

Hovelson, D. H., Xue, Z., Zawistowski, M., Ehm, M. G., Harris, E. C., Stocker, S. L., Gross, A. S., Jang, I. J., Ieiri, I., Lee, J. E., Cardon, L. R., Chissoe, S. L., Abecasis, G. & Nelson, M. R., Jan 1 2017, In : Pharmacogenetics and Genomics. 27, 3, p. 89-100 12 p.

Research output: Contribution to journalArticle

Exome
Population
Genes
Gene Frequency
3 Citations (Scopus)

Epigenetic regulation of drug transporter expression in human tissues

Hirota, T., Tanaka, T., Takesue, H. & Ieiri, I., Jan 2 2017, In : Expert Opinion on Drug Metabolism and Toxicology. 13, 1, p. 19-30 12 p.

Research output: Contribution to journalReview article

Drug and Narcotic Control
Epigenomics
Tissue
Pharmaceutical Preparations
Genes
8 Citations (Scopus)

Involvement of Organic Cation Transporters in the Kinetics of Trimethylamine N-oxide

Miyake, T., Mizuno, T., Mochizuki, T., Kimura, M., Matsuki, S., Irie, S., Ieiri, I., Maeda, K. & Kusuhara, H., Sep 1 2017, In : Journal of Pharmaceutical Sciences. 106, 9, p. 2542-2550 9 p.

Research output: Contribution to journalArticle

Cations
Kidney
trimethyloxamine
Tetraethylammonium
Tissue Distribution
16 Citations (Scopus)

Small-Dosing Clinical Study: Pharmacokinetic, Pharmacogenomic (SLCO2B1 and ABCG2), and Interaction (Atorvastatin and Grapefruit Juice) Profiles of 5 Probes for OATP2B1 and BCRP

Kashihara, Y., Ieiri, I., Yoshikado, T., Maeda, K., Fukae, M., Kimura, M., Hirota, T., Matsuki, S., Irie, S., Izumi, N., Kusuhara, H. & Sugiyama, Y., Sep 1 2017, In : Journal of Pharmaceutical Sciences. 106, 9, p. 2688-2694 7 p.

Research output: Contribution to journalArticle

Citrus paradisi
Pharmacogenetics
Pharmacokinetics
Sulfasalazine
Pharmaceutical Preparations
2016

Chapter 5: Pharmacogenomics of Drug Transporters: Clinical Implications

Ieiri, I., Jan 1 2016, Privileged Scaffolds in Medicinal Chemistry: Design, Synthesis, Evaluation. 55 ed. Royal Society of Chemistry, p. 114-142 29 p. (RSC Drug Discovery Series; vol. 2016-January, no. 55).

Research output: Chapter in Book/Report/Conference proceedingChapter

Pharmacogenetics
P-Glycoprotein
Pharmaceutical Preparations
Pharmacokinetics
Genes
8 Citations (Scopus)

Circulating intestine-derived exosomal miR-328 in plasma, a possible biomarker for estimating BCRP function in the human intestines

Gotanda, K., Hirota, T., Saito, J., Fukae, M., Egashira, Y., Izumi, N., Deguchi, M., Kimura, M., Matsuki, S., Irie, S. & Ieiri, I., Aug 30 2016, In : Scientific reports. 6, 32299.

Research output: Contribution to journalArticle

Intestines
Biomarkers
Breast Neoplasms
Proteins
Area Under Curve
18 Citations (Scopus)

Clarification of the mechanism of clopidogrel-mediated drug-drug interaction in a clinical cassette small-dose study and its prediction based on in vitro information

Kim, S. J., Yoshikado, T., Ieiri, I., Maeda, K., Kimura, M., Irie, S., Kusuhara, H. & Sugiyama, Y., Oct 1 2016, In : Drug Metabolism and Disposition. 44, 10, p. 1622-1632 11 p.

Research output: Contribution to journalArticle

clopidogrel
repaglinide
pioglitazone
Drug Interactions
Pharmaceutical Preparations
Human Body
Pharmacokinetics
Pharmaceutical Preparations
Renal Elimination
1 Citation (Scopus)

Population pharmacodynamic analysis of hemoglobin A1c-lowering effects by adding treatment of DPP-4 inhibitors (sitagliptin) in type 2 diabetes mellitus patients based on electronic medical records

Kakara, M., Nomura, H., Ezaki, M., Fukae, M., Hirota, T., Matsubayashi, S., Hirakawa, M. & Ieiri, I., Sep 1 2016, In : Journal of Diabetes and Its Complications. 30, 7, p. 1282-1286 5 p.

Research output: Contribution to journalArticle

Electronic Health Records
pioglitazone
Type 2 Diabetes Mellitus
Hemoglobins
Population
7 Citations (Scopus)

Population pharmacokinetic–pharmacodynamic modeling and model-based prediction of docetaxel-induced neutropenia in Japanese patients with non-small cell lung cancer

Fukae, M., Shiraishi, Y., Hirota, T., Sasaki, Y., Yamahashi, M., Takayama, K., Nakanishi, Y. & Ieiri, I., Nov 1 2016, In : Cancer chemotherapy and pharmacology. 78, 5, p. 1013-1023 11 p.

Research output: Contribution to journalArticle

docetaxel
Neutropenia
Non-Small Cell Lung Carcinoma
Cells
Population
2015
27 Citations (Scopus)

Drug-drug interactions that interfere with statin metabolism

Hirota, T. & Ieiri, I., Sep 2 2015, In : Expert Opinion on Drug Metabolism and Toxicology. 11, 9, p. 1435-1447 13 p.

Research output: Contribution to journalReview article

Drug interactions
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Drug Interactions
Metabolism
Pharmaceutical Preparations
4 Citations (Scopus)

Effects of multiple-dose rifampicin 450 mg on the pharmacokinetics of fexofenadine enantiomers in Japanese volunteers

Akamine, Y., Miura, M., Yasui-Furukori, N., Ieiri, I. & Uno, T., Jan 1 2015, In : Journal of Clinical Pharmacy and Therapeutics. 40, 1, p. 98-103 6 p.

Research output: Contribution to journalArticle

fexofenadine
Rifampin
Volunteers
Pharmacokinetics
P-Glycoprotein

Pharmacogenomics of anti-cancer drugs for individual treatment

Ieiri, I., Feb 1 2015, In : Nippon rinsho. Japanese journal of clinical medicine. 73, p. 120-125 6 p.

Research output: Contribution to journalArticle

Precision Medicine
Drug Monitoring
Pharmacogenetics
Human Genome
Antineoplastic Agents
1 Citation (Scopus)
Biological Transport
Hypoglycemic Agents
Pharmacokinetics
Kidney
Liver
6 Citations (Scopus)

Sulfasalazine disposition in a subject with 376C>T (nonsense mutation) and 421C>A variants in the ABCG2 gene

Gotanda, K., Tokumoto, T., Hirota, T., Fukae, M. & Ieiri, I., Nov 1 2015, In : British journal of clinical pharmacology. 80, 5, p. 1236-1237 2 p.

Research output: Contribution to journalLetter

Neoplasm Proteins
Sulfasalazine
ATP-Binding Cassette Transporters
Nonsense Codon
Genetic Polymorphisms
11 Citations (Scopus)

The change of pharmacokinetics of fexofenadine enantiomers through the single and simultaneous grapefruit juice ingestion

Akamine, Y., Miura, M., Komori, H., Tamai, I., Ieiri, I., Yasui-Furukori, N. & Uno, T., Oct 10 2015, In : Drug metabolism and pharmacokinetics. 30, 5, p. 352-357 6 p.

Research output: Contribution to journalArticle

fexofenadine
Citrus paradisi
Pharmacokinetics
Eating
2014
30 Citations (Scopus)

Addition of bevacizumab enhances antitumor activity of erlotinib against non-small cell lung cancer xenografts depending on VEGF expression

Li, H., Takayama, K., Wang, S., Shiraishi, Y., Gotanda, K., Harada, T., Furuyama, K., Iwama, E., Ieiri, I., Okamoto, I. & Nakanishi, Y., Oct 9 2014, In : Cancer chemotherapy and pharmacology. 74, 6, p. 1297-1305 9 p.

Research output: Contribution to journalArticle

Heterografts
Non-Small Cell Lung Carcinoma
Vascular Endothelial Growth Factor A
Cells
Tumors
11 Citations (Scopus)

Effects of one-time apple juice ingestion on the pharmacokinetics of fexofenadine enantiomers

Akamine, Y., Miura, M., Komori, H., Saito, S., Kusuhara, H., Tamai, I., Ieiri, I., Uno, T. & Yasui-Furukori, N., Jan 1 2014, In : European Journal of Clinical Pharmacology. 70, 9, p. 1087-1095 9 p.

Research output: Contribution to journalArticle

fexofenadine
Malus
Pharmacokinetics
Eating
Anions
8 Citations (Scopus)

Identification and functional characterization of novel nonsynonymous variants in the human multidrug and toxin extrusion 2-K

Nishimura, K., Ide, R., Hirota, T., Kawazu, K., Kodama, S., Takesue, H. & Ieiri, I., Jan 1 2014, In : Drug Metabolism and Disposition. 42, 9, p. 1432-1437 6 p.

Research output: Contribution to journalArticle

Single Nucleotide Polymorphism
Cations
Cell Membrane
Antiporters
Tetraethylammonium
2 Citations (Scopus)

Influences of artificial heart-lung machine operation on the binding sites of albumin: Possibility of an effective administration plan

Totoribe, K., Takamura, N., Ogata, K., Tokunaga, J., Kawai, K., Nakamura, K., Ieiri, I. & Higuchi, S., Jan 1 2014, In : International Journal of Artificial Organs. 37, 2, p. 99-108 10 p.

Research output: Contribution to journalArticle

Heart-Lung Machine
Artificial heart
Artificial Heart
Binding sites
Serum Albumin
10 Citations (Scopus)

Korean, Japanese, and Chinese populations featured similar genes encoding drug-metabolizing enzymes and transporters: A DMET Plus microarray assessment

Yi, S., An, H., Lee, H., Lee, S., Ieiri, I., Lee, Y., Cho, J. Y., Hirota, T., Fukae, M., Yoshida, K., Nagatsuka, S., Kimura, M., Irie, S., Sugiyama, Y., Shin, D. W., Lim, K. S., Chung, J. Y., Yu, K. S. & Jang, I. J., Oct 10 2014, In : Pharmacogenetics and Genomics. 24, 10, p. 477-485 9 p.

Research output: Contribution to journalArticle

Ethnic Groups
Enzymes
Principal Component Analysis
Pharmaceutical Preparations
Population
2 Citations (Scopus)

Mechanism of the 24-hour rhythm of tumor necrosis factor-alpha formed by onset of rheumatoid arthritis

Yoshimatsu, H., Okazaki, F., Ieiri, I. & To, H., Jan 1 2014, In : Chronobiology International. 31, 4, p. 564-571 8 p.

Research output: Contribution to journalArticle

Lymphotoxin-alpha
Rheumatoid Arthritis
Tumor Necrosis Factor-alpha
Cytokines
Serum Amyloid A Protein
4 Citations (Scopus)

Modeling and simulation of bone mineral density response from a phase 2 study of ONO-5334, a new cathepsin K inhibitor, to support dose selection in osteoporosis

Hasegawa, C., Kastrissios, H., Monteleone, J., Ohno, T., Umemura, T., Ohyama, M., Nagase, S., Small, M., Deacon, S., Ogawa, M. & Ieiri, I., Jan 1 2014, In : Journal of Clinical Pharmacology. 54, 8, p. 937-948 12 p.

Research output: Contribution to journalArticle

Cathepsin K
Bone Density
Tablets
Osteoporosis
Pharmacokinetics
5 Citations (Scopus)

Neonatal Dubin-Johnson syndrome: Novel compound heterozygous mutation in the ABCC2 gene

Okada, H., Kusaka, T., Fuke, N., Kunikata, J., Kondo, S., Iwase, T., Nan, W., Hirota, T., Ieiri, I. & Itoh, S., Jan 1 2014, In : Pediatrics International. 56, 5, p. e62-e64

Research output: Contribution to journalArticle

Chronic Idiopathic Jaundice
Bilirubin
Mutation
Missense Mutation
Genes
6 Citations (Scopus)

Population pharmacodynamic analysis of LDL-cholesterol lowering effects by statins and co-medications based on electronic medical records

Kakara, M., Nomura, H., Fukae, M., Gotanda, K., Hirota, T., Matsubayashi, S., Shimomura, H., Hirakawa, M. & Ieiri, I., Oct 1 2014, In : British journal of clinical pharmacology. 78, 4, p. 824-835 12 p.

Research output: Contribution to journalArticle

Hydroxymethylglutaryl-CoA Reductase Inhibitors
Electronic Health Records
LDL Cholesterol
Population
Anticholesteremic Agents
5 Citations (Scopus)

Population pharmacokinetic and pharmacodynamic modeling of different formulations of ono-5334, cathepsin k inhibitor, in caucasian and japanese postmenopausal females

Hasegawa, C., Ohno, T., Umemura, T., Honda, N., Ohyama, M., Nagase, S., Small, M., Deacon, S., Ogawa, M. & Ieiri, I., Jan 1 2014, In : Journal of Clinical Pharmacology. 54, 1, p. 23-34 12 p.

Research output: Contribution to journalArticle

Cathepsins
Tablets
Pharmacokinetics
Bone Resorption
Population
1 Citation (Scopus)
Secretory Phospholipase A2
Hydroxymethylglutaryl-CoA Reductase Inhibitors
LDL Lipoproteins
Endothelial Cells
Tumor Necrosis Factor-alpha
Osteoporosis
Pharmacokinetics
Pharmaceutical Preparations
Population
Bone Remodeling
2013
32 Citations (Scopus)

Apple juice greatly reduces systemic exposure to atenolol

Jeon, H., Jang, I. J., Lee, S., Ohashi, K., Kotegawa, T., Ieiri, I., Cho, J. Y., Yoon, S. H., Shin, S. G., Yu, K. S. & Lim, K. S., Jan 2013, In : British Journal of Clinical Pharmacology. 75, 1, p. 172-179 8 p.

Research output: Contribution to journalArticle

Atenolol
Malus
Pharmacokinetics
Water
Healthy Volunteers
17 Citations (Scopus)
5' Flanking Region
DNA methylation
DNA Methylation
placenta
Individuality
13 Citations (Scopus)

Clinical impact of genetic variants of drug transporters in different ethnic groups within and across regions

Ono, C., Kikkawa, H., Suzuki, A., Suzuki, M., Yamamoto, Y., Ichikawa, K., Fukae, M. & Ieiri, I., Jan 1 2013, In : Pharmacogenomics. 14, 14, p. 1745-1764 20 p.

Research output: Contribution to journalReview article

Ethnic Groups
Pharmaceutical Preparations
Precision Medicine
Far East
Pharmacokinetics
2 Citations (Scopus)

Direct and rapid genotyping of SLCO1B1 388A>G and 521T>C in human blood specimens using the SmartAmp-2 method

Yoshida, K., Takano, J., Ishizu, Y., Lezhava, A., Ieiri, I., Maeda, K., Hayashizaki, Y. & Sugiyama, Y., Apr 1 2013, In : AAPS Journal. 15, 2, p. 618-622 5 p.

Research output: Contribution to journalArticle

Genotype
Solute Carrier Organic Anion Transporter Family Member 1b1
Anions
Pharmacokinetics
Pharmaceutical Preparations
63 Citations (Scopus)

Impact of genetic polymorphisms in CYP2C9 and CYP2C19 on the pharmacokinetics of clinically used drugs

Hirota, T., Eguchi, S. & Ieiri, I., Jan 1 2013, In : Drug Metabolism and Pharmacokinetics. 28, 1, p. 28-37 10 p.

Research output: Contribution to journalReview article

Genetic Polymorphisms
Pharmacokinetics
Pharmaceutical Preparations
Precision Medicine
Xenobiotics
23 Citations (Scopus)

Mechanisms of pharmacokinetic enhancement between ritonavir and saquinavir; micro/small dosing tests using midazolam (CYP3A4), fexofenadine (p-Glycoprotein), and pravastatin (OATP1B1) as probe drugs

Ieiri, I., Tsunemitsu, S., Maeda, K., Ando, Y., Izumi, N., Kimura, M., Yamane, N., Okuzono, T., Morishita, M., Kotani, N., Kanda, E., Deguchi, M., Matsuguma, K., Matsuki, S., Hirota, T., Irie, S., Kusuhara, H. & Sugiyama, Y., Jun 1 2013, In : Journal of Clinical Pharmacology. 53, 6, p. 654-661 8 p.

Research output: Contribution to journalArticle

fexofenadine
Saquinavir
Cytochrome P-450 CYP3A
Pravastatin
Ritonavir