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Research Output 1998 2020

2018
686 Citations (Scopus)

Osimertinib in untreated EGFR-Mutated advanced non-small-cell lung cancer

Soria, J. C., Ohe, Y., Vansteenkiste, J., Reungwetwattana, T., Chewaskulyong, B., Lee, K. H., Dechaphunkul, A., Imamura, F., Nogami, N., Kurata, T., Okamoto, I., Zhou, C., Cho, B. C., Cheng, Y., Cho, E. K., Voon, P. J., Planchard, D., Su, W. C., Gray, J. E., Lee, S. M. & 4 others, Hodge, R., Marotti, M., Rukazenkov, Y. & Ramalingam, S. S., Jan 11 2018, In : New England Journal of Medicine. 378, 2, p. 113-125 13 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Confidence Intervals
Epidermal Growth Factor Receptor
Protein-Tyrosine Kinases
Mutation
16 Citations (Scopus)

PD-L1 expression in lung adenocarcinoma harboring EGFR mutations or ALK rearrangements

Yoneshima, Y., Ijichi, K., Anai, S., Ota, K., Otsubo, K., Iwama, E., Tanaka, K., Oda, Y., Nakanishi, Y. & Okamoto, I., Apr 2018, In : Lung Cancer. 118, p. 36-40 5 p.

Research output: Contribution to journalArticle

Mutation
Neoplasms
Adenocarcinoma of lung
Protein-Tyrosine Kinases
Oncogenes
9 Citations (Scopus)

PD-L2 expression as a potential predictive biomarker for the response to anti-PD-1 drugs in patients with non-small cell lung cancer

Takamori, S., Takada, K., Toyokawa, G., Azuma, K., Shimokawa, M., Jogo, T., Yamada, Y., Hirai, F., Tagawa, T., Kawahara, A., Akiba, J., Okamoto, I., Nakanishi, Y., Oda, Y., Hoshino, T. & Maehara, Y., Oct 2018, In : Anticancer research. 38, 10, p. 5897-5901 5 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Cell Death
Biomarkers
Ligands
Pharmaceutical Preparations
5 Citations (Scopus)

Phase 3 study of ceritinib vs chemotherapy in ALK-rearranged NSCLC patients previously treated with chemotherapy and crizotinib (ASCEND-5): Japanese subset

Kiura, K., Imamura, F., Kagamu, H., Matsumoto, S., Hida, T., Nakagawa, K., Satouchi, M., Okamoto, I., Takenoyama, M., Fujisaka, Y., Kurata, T., Ito, M., Tokushige, K., Hatano, B. & Nishio, M., Apr 1 2018, In : Japanese journal of clinical oncology. 48, 4, p. 367-375 9 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Drug Therapy
docetaxel
Pemetrexed
Disease-Free Survival
3 Citations (Scopus)

Phase I/II study of carboplatin plus nab-paclitaxel and concurrent radiotherapy for patients with locally advanced non–small cell lung cancer

Kawano, Y., Sasaki, T., Yamaguchi, H., Hirano, K., Horiike, A., Satouchi, M., Hosokawa, S., Morinaga, R., Komiya, K., Inoue, K., Fujita, Y., Toyozawa, R., Kimura, T., Takahashi, K., Nishikawa, K., Kishimoto, J., Nakanishi, Y. & Okamoto, I., Nov 2018, In : Lung Cancer. 125, p. 136-141 6 p.

Research output: Contribution to journalArticle

Carboplatin
Non-Small Cell Lung Carcinoma
Radiotherapy
Leukopenia
Confidence Intervals
1 Citation (Scopus)
Therapeutic Uses
Platinum
Non-Small Cell Lung Carcinoma
Perfusion
Tomography
20 Citations (Scopus)

Prevalence of Delta-like protein 3 expression in patients with small cell lung cancer

Tanaka, K., Isse, K., Fujihira, T., Takenoyama, M., Saunders, L., Bheddah, S., Nakanishi, Y. & Okamoto, I., Jan 2018, In : Lung Cancer. 115, p. 116-120 5 p.

Research output: Contribution to journalArticle

Small Cell Lung Carcinoma
delta protein
Neoplasms
Sex Characteristics
Japan
2 Citations (Scopus)

Prognostic impact of PD-L2 expression and association with PD-L1 in patients with small-cell lung cancer

Takamori, S., Takada, K., Azuma, K., Jogo, Y., Kinoshita, F., Kozuma, Y., Matsubara, T., Haratake, N., Akamine, T., Toyokawa, G., Hirai, F., Tagawa, T., Okamoto, I., Nakanishi, Y., Kawahara, A., Akiba, J., Oda, Y. & Maehara, Y., Oct 2018, In : Anticancer research. 38, 10, p. 5903-5907 5 p.

Research output: Contribution to journalArticle

Small Cell Lung Carcinoma
Cell Death
Ligands
Lung Neoplasms
Programmed Cell Death 1 Ligand 2 Protein
1 Citation (Scopus)

Radiological features of programmed cell death-ligand 2-positive lung adenocarcinoma: A single-institution retrospective study

Takada, K., Toyokawa, G., Azuma, K., Takamori, S., Jogo, T., Hirai, F., Tagawa, T., Kawahara, A., Akiba, J., Okamoto, I., Nakanishi, Y., Oda, Y., Hoshino, T. & Maehara, Y., Nov 1 2018, In : In Vivo. 32, 6, p. 1541-1550 10 p.

Research output: Contribution to journalArticle

Fluorodeoxyglucose F18
Cell death
Tomography
Cell Death
Retrospective Studies
14 Citations (Scopus)

Real world treatment and outcomes in EGFR mutation-positive non-small cell lung cancer: Long-term follow-up of a large patient cohort

Okamoto, I., Morita, S., Tashiro, N., Imamura, F., Inoue, A., Seto, T., Yamamoto, N., Ohe, Y., Nakagawa, K. & Fukuoka, M., Mar 2018, In : Lung Cancer. 117, p. 14-19 6 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Mutation
Epidermal Growth Factor Receptor
Protein-Tyrosine Kinases
Survival

Sensitivity of epidermal growth factor receptor with single or double uncommon mutations to afatinib confirmed by a visual assay

Kimura, S., Tanaka, K., Harada, T., Liu, R., Shibahara, D., Kawano, Y., Nakanishi, Y. & Okamoto, I., Nov 2018, In : Cancer Science. 109, 11, p. 3657-3661 5 p.

Research output: Contribution to journalArticle

Epidermal Growth Factor Receptor
Mutation
Protein-Tyrosine Kinases
Non-Small Cell Lung Carcinoma
BIBW 2992
18 Citations (Scopus)

Treatment Rationale and Design for J-SONIC: A Randomized Study of Carboplatin Plus Nab-paclitaxel With or Without Nintedanib for Advanced Non–Small-cell Lung Cancer With Idiopathic Pulmonary Fibrosis

Otsubo, K., Kishimoto, J., Kenmotsu, H., Minegishi, Y., Ichihara, E., Shiraki, A., Kato, T., Atagi, S., Horinouchi, H., Ando, M., Kondoh, Y., Kusumoto, M., Ichikado, K., Yamamoto, N., Nakanishi, Y. & Okamoto, I., Jan 2018, In : Clinical Lung Cancer. 19, 1, p. e5-e9

Research output: Contribution to journalArticle

Idiopathic Pulmonary Fibrosis
Carboplatin
Non-Small Cell Lung Carcinoma
Nanoparticles
Therapeutics
2017
13 Citations (Scopus)

Alectinib for Patients with ALK Rearrangement–Positive Non–Small Cell Lung Cancer and a Poor Performance Status (Lung Oncology Group in Kyushu 1401)

Iwama, E., Goto, Y., Murakami, H., Harada, T., Tsumura, S., Sakashita, H., Mori, Y., Nakagaki, N., Fujita, Y., Seike, M., Bessho, A., Ono, M., Okazaki, A., Akamatsu, H., Morinaga, R., Ushijima, S., Shimose, T., Tokunaga, S., Hamada, A., Yamamoto, N. & 3 others, Nakanishi, Y., Sugio, K. & Okamoto, I., Jul 2017, In : Journal of Thoracic Oncology. 12, 7, p. 1161-1166 6 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Lung
Confidence Intervals
Patient Safety
CH5424802
6 Citations (Scopus)

A Randomized Phase II Study Comparing Nivolumab With Carboplatin-Pemetrexed for Patients With EGFR Mutation–Positive Nonsquamous Non–Small-Cell Lung Cancer Who Acquire Resistance to Tyrosine Kinase Inhibitors Not Due to a Secondary T790M Mutation: Rationale and Protocol Design for the WJOG8515L Study

Hayashi, H., Chiba, Y., Sakai, K., Fujita, T., Yoshioka, H., Sakai, D., Kitagawa, C., Naito, T., Takeda, K., Okamoto, I., Mitsudomi, T., Kawakami, Y., Nishio, K., Nakamura, S., Yamamoto, N. & Nakagawa, K., Nov 2017, In : Clinical Lung Cancer. 18, 6, p. 719-723 5 p.

Research output: Contribution to journalArticle

Pemetrexed
erbB-1 Genes
Carboplatin
Non-Small Cell Lung Carcinoma
Protein-Tyrosine Kinases
4 Citations (Scopus)

CD44 variant–dependent regulation of redox balance in EGFR mutation–positive non–small cell lung cancer: A target for treatment

Kawano, Y., Iwama, E., Tsuchihashi, K., Shibahara, D., Harada, T., Tanaka, K., Nagano, O., Saya, H., Nakanishi, Y. & Okamoto, I., Nov 2017, In : Lung Cancer. 113, p. 72-78 7 p.

Research output: Contribution to journalArticle

erbB-1 Genes
Non-Small Cell Lung Carcinoma
Oxidation-Reduction
Reactive Oxygen Species
Cisplatin
1 Citation (Scopus)

Chronic myelomonocytic leukemia blast crisis in a patient with advanced non-small cell lung cancer treated with EGFR tyrosine kinase inhibitors

Ogata, H., Okamoto, I., Yoshimoto, G., Obara, T., Ijichi, K., Iwama, E., Harada, T., Akashi, K. & Nakanishi, Y., Mar 1 2017, In : Respiratory Investigation. 55, 2, p. 181-183 3 p.

Research output: Contribution to journalArticle

Leukemia, Myelomonocytic, Chronic
erbB-1 Genes
Blast Crisis
Non-Small Cell Lung Carcinoma
Protein-Tyrosine Kinases
16 Citations (Scopus)

Discrepancy in programmed cell death-ligand 1 between primary and metastatic non-small cell lung cancer

Takamori, S., Toyokawa, G., Okamoto, I., Takada, K., Kozuma, Y., Matsubara, T., Haratake, N., Akamine, T., Katsura, M., Mukae, N., Shoji, F., Okamoto, T., Oda, Y., Iwaki, T., Iihara, K., Nakanishi, Y. & Maehara, Y., Aug 2017, In : Anticancer research. 37, 8, p. 4223-4228 6 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Cell Death
Ligands
Radiotherapy
Brain
10 Citations (Scopus)

Marked response to pembrolizumab in a patient with pulmonary pleomorphic carcinoma highly positive for PD-L1

Ikematsu, Y., Yoneshima, Y., Ijichi, K., Tanaka, K., Harada, T., Oda, Y., Nakanishi, Y. & Okamoto, I., Oct 2017, In : Lung Cancer. 112, p. 230-231 2 p.

Research output: Contribution to journalLetter

Carcinoma
Lung
pembrolizumab
2 Citations (Scopus)

Meta-analysis of pemetrexed plus carboplatin doublet safety profile in first-line non-squamous non-small cell lung cancer studies

Okamoto, I., Schuette, W. H. W., Stinchcombe, T. E., Rodrigues-Pereira, J., San Antonio, B., Chen, J., Liu, J., John, W. J. & Zinner, R. G., May 4 2017, In : Current Medical Research and Opinion. 33, 5, p. 937-941 5 p.

Research output: Contribution to journalArticle

Pemetrexed
Carboplatin
Non-Small Cell Lung Carcinoma
Meta-Analysis
Safety
25 Citations (Scopus)

Monitoring of somatic mutations in circulating cell-free DNA by digital PCR and next-generation sequencing during afatinib treatment in patients with lung adenocarcinoma positive for EGFR activating mutations

Iwama, E., Sakai, K., Azuma, K., Harada, T., Harada, D., Nosaki, K., Hotta, K., Ohyanagi, F., Kurata, T., Fukuhara, T., Akamatsu, H., Goto, K., Shimose, T., Kishimoto, J., Nakanishi, Y., Nishio, K. & Okamoto, I., Jan 1 2017, In : Annals of Oncology. 28, 1, p. 136-141 6 p.

Research output: Contribution to journalArticle

Epidermal Growth Factor Receptor
Polymerase Chain Reaction
Mutation
DNA
Alleles
18 Citations (Scopus)

Most T790M mutations are present on the same EGFR allele as activating mutations in patients with non–small cell lung cancer

Hidaka, N., Iwama, E., Kubo, N., Harada, T., Miyawaki, K., Tanaka, K., Okamoto, I., Baba, E., Akashi, K., Sasaki, H. & Nakanishi, Y., Jun 1 2017, In : Lung Cancer. 108, p. 75-82 8 p.

Research output: Contribution to journalArticle

erbB-1 Genes
Non-Small Cell Lung Carcinoma
Alleles
Mutation
Protein-Tyrosine Kinases
4 Citations (Scopus)

Phase I study of irinotecan for previously treated lung cancer patients with the UGT1A1*28 or *6 polymorphism: Results of the Lung Oncology Group in Kyushu (LOGIK1004A)

Fukuda, M., Shimada, M., Kitazaki, T., Nagashima, S., Hashiguchi, K., Ebi, N., Takayama, K., Nakanishi, Y., Semba, H., Harada, T., Seto, T., Okamoto, I., Ichinose, Y. & Sugio, K., Jan 1 2017, In : Thoracic Cancer. 8, 1, p. 40-45 6 p.

Research output: Contribution to journalArticle

irinotecan
Lung Neoplasms
Lung
Maximum Tolerated Dose
Glucuronosyltransferase
8 Citations (Scopus)

Phase I study of salazosulfapyridine in combination with cisplatin and pemetrexed for advanced non-small-cell lung cancer

Otsubo, K., Nosaki, K., Imamura, C. K., Ogata, H., Fujita, A., Sakata, S., Hirai, F., Toyokawa, G., Iwama, E., Harada, T., Seto, T., Takenoyama, M., Ozeki, T., Mushiroda, T., Inada, M., Kishimoto, J., Tsuchihashi, K., Suina, K., Nagano, O., Saya, H. & 2 others, Nakanishi, Y. & Okamoto, I., Sep 2017, In : Cancer Science. 108, 9, p. 1843-1849 7 p.

Research output: Contribution to journalArticle

Pemetrexed
Sulfasalazine
Non-Small Cell Lung Carcinoma
Cisplatin
Neoplastic Stem Cells
Aplastic Anemia
Non-Small Cell Lung Carcinoma
Protein-Tyrosine Kinases
Therapeutics
osimertinib
2 Citations (Scopus)

Treatment Rationale and Design for J-AXEL: A Randomized Phase 3 Study Comparing Nab-Paclitaxel With Docetaxel in Patients With Previously Treated Advanced Non–Small-Cell Lung Cancer

Yoneshima, Y., Morita, S., Ando, M., Miura, S., Yoshioka, H., Abe, T., Kato, T., Kondo, M., Hosomi, Y., Hotta, K., Yamamoto, N., Kishimoto, J., Nakanishi, Y. & Okamoto, I., Jan 1 2017, In : Clinical Lung Cancer. 18, 1, p. 100-103 4 p.

Research output: Contribution to journalArticle

docetaxel
Non-Small Cell Lung Carcinoma
Nanoparticles
Therapeutics
Disease Progression
4 Citations (Scopus)
7 Citations (Scopus)

Two cases of late-onset secondary adrenal insufficiency after discontinuation of nivolumab

Otsubo, K., Nakatomi, K., Furukawa, R., Ashida, K., Yoneshima, Y., Nakanishi, Y. & Okamoto, I., Dec 1 2017, In : Annals of Oncology. 28, 12, p. 3106-3107 2 p.

Research output: Contribution to journalLetter

Adrenal Insufficiency
nivolumab
2016
46 Citations (Scopus)

Anti-HER3 monoclonal antibody patritumab sensitizes refractory non-small cell lung cancer to the epidermal growth factor receptor inhibitor erlotinib

Yonesaka, K., Hirotani, K., Kawakami, H., Takeda, M., Kaneda, H., Sakai, K., Okamoto, I., Nishio, K., Jänne, P. A. & Nakagawa, K., Feb 18 2016, In : Oncogene. 35, 7, p. 878-886 9 p.

Research output: Contribution to journalArticle

Neuregulin-1
Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
Monoclonal Antibodies
Protein-Tyrosine Kinases
31 Citations (Scopus)

Bevacizumab beyond disease progression after first-line treatment with bevacizumab plus chemotherapy in advanced nonsquamous non-small cell lung cancer (West Japan Oncology Group 5910L): An open-label, randomized, phase 2 trial

Takeda, M., Yamanaka, T., Seto, T., Hayashi, H., Azuma, K., Okada, M., Sugawara, S., Daga, H., Hirashima, T., Yonesaka, K., Urata, Y., Murakami, H., Saito, H., Kubo, A., Sawa, T., Miyahara, E., Nogami, N., Nakagawa, K., Nakanishi, Y. & Okamoto, I., Apr 1 2016, In : Cancer. 122, 7, p. 1050-1059 10 p.

Research output: Contribution to journalArticle

docetaxel
Non-Small Cell Lung Carcinoma
Disease Progression
Japan
Drug Therapy
29 Citations (Scopus)

Characteristics and overall survival of EGFR mutation-positive non-small cell lung cancer treated with EGFR tyrosine kinase inhibitors: A retrospective analysis for 1660 Japanese patients

Inoue, A., Yoshida, K., Morita, S., Imamura, F., Seto, T., Okamoto, I., Nakagawa, K., Yamamoto, N., Muto, S. & Fukuoka, M., Jan 1 2016, In : Japanese journal of clinical oncology. 46, 5, p. 462-467 6 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Protein-Tyrosine Kinases
Epidermal Growth Factor Receptor
Mutation
Survival
5 Citations (Scopus)

Characteristics of smoking patients with lung cancer with emphysematous bullae

Iwama, E., Okamoto, I., Yabuuchi, H., Takayama, K., Harada, T., Matsuo, Y., Tokunaga, S., Baba, E. & Nakanishi, Y., Jan 1 2016, In : Journal of Thoracic Oncology. 11, 9, p. 1586-1590 5 p.

Research output: Contribution to journalArticle

Blister
Lung Neoplasms
Smoking
Emphysema
Epidermal Growth Factor
73 Citations (Scopus)

Effect of dose adjustment on the safety and efficacy of afatinib for EGFR mutation-positive lung adenocarcinoma: Post hoc analyses of the randomized LUX-Lung 3 and 6 trials

Yang, J. C. H., Sequist, L. V., Zhou, C., Schuler, M., Geater, S. L., Mok, T., Hu, C. P., Yamamoto, N., Feng, J., O'Byrne, K., Lu, S., Hirsh, V., Huang, Y., Sebastian, M., Okamoto, I., Dickgreber, N., Shah, R., Märten, A., Massey, D., Wind, S. & 1 others, Wu, Y. L., Jan 1 2016, In : Annals of Oncology. 27, 11, p. 2103-2110 8 p.

Research output: Contribution to journalArticle

Safety
Lung
Mutation
Disease-Free Survival
Non-Small Cell Lung Carcinoma
13 Citations (Scopus)

FGFR gene alterations in lung squamous cell carcinoma are potential targets for the multikinase inhibitor nintedanib

Hibi, M., Kaneda, H., Tanizaki, J., Sakai, K., Togashi, Y., Terashima, M., De Velasco, M. A., Fujita, Y., Banno, E., Nakamura, Y., Takeda, M., Ito, A., Mitsudomi, T., Nakagawa, K., Okamoto, I. & Nishio, K., Nov 1 2016, In : Cancer Science. 107, 11, p. 1667-1676 10 p.

Research output: Contribution to journalArticle

Fibroblast Growth Factor Receptors
Squamous Cell Carcinoma
Lung
Genes
Cell Line
25 Citations (Scopus)

HER2 genomic amplification in circulating tumor DNA from patients with cetuximab-resistant colorectal cancer

Takegawa, N., Yonesaka, K., Sakai, K., Ueda, H., Watanabe, S., Nonagase, Y., Okuno, T., Takeda, M., Maenishi, O., Tsurutani, J., Satoh, T., Okamoto, I., Nishio, K., Tamura, T. & Nakagawa, K., Jan 1 2016, In : Oncotarget. 7, 3, p. 3453-3460 8 p.

Research output: Contribution to journalArticle

Colorectal Neoplasms
Epidermal Growth Factor Receptor
DNA
Neoplasms
Antibodies
12 Citations (Scopus)

MET-targeted therapy for gastric cancer: the importance of a biomarker-based strategy

Kawakami, H. & Okamoto, I., Jul 1 2016, In : Gastric Cancer. 19, 3, p. 687-695 9 p.

Research output: Contribution to journalArticle

Stomach Neoplasms
Biomarkers
Hepatocyte Growth Factor
Protein-Tyrosine Kinases
Neoplasms
15 Citations (Scopus)

Phase II study of erlotinib plus tivantinib (ARQ 197) in patients with locally advanced or metastatic EGFR mutation-positive non-small-cell lung cancer just after progression on EGFR-TKI, gefitinib or erlotinib

Azuma, K., Hirashima, T., Yamamoto, N., Okamoto, I., Takahashi, T., Nishio, M., Hirata, T., Kubota, K., Kasahara, K., Hida, T., Yoshioka, H., Nakanishi, K., Akinaga, S., Nishio, K., Mitsudomi, T. & Nakagawa, K., Jul 2016, In : ESMO Open. 1, 4, e000063.

Research output: Contribution to journalArticle

Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
Mutation
Hepatocyte Growth Factor
Disease-Free Survival
15 Citations (Scopus)

Phase II trial of weekly nab-paclitaxel for previously treated advanced non–small cell lung cancer: Kumamoto thoracic oncology study group (KTOSG) trial 1301

Sakata, S., Saeki, S., Okamoto, I., Otsubo, K., Komiya, K., Morinaga, R., Yoneshima, Y., Koga, Y., Enokizu, A., Kishi, H., Hirosako, S., Yamaguchi, E., Aragane, N., Fujii, S., Harada, T., Iwama, E., Semba, H., Nakanishi, Y. & Kohrogi, H., Sep 1 2016, In : Lung Cancer. 99, p. 41-45 5 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Thorax
docetaxel
Confidence Intervals
Febrile Neutropenia
52 Citations (Scopus)

Re-biopsy status among non-small cell lung cancer patients in Japan: A retrospective study

Nosaki, K., Satouchi, M., Kurata, T., Yoshida, T., Okamoto, I., Katakami, N., Imamura, F., Tanaka, K., Yamane, Y., Yamamoto, N., Kato, T., Kiura, K., Saka, H., Yoshioka, H., Watanabe, K., Mizuno, K. & Seto, T., Nov 1 2016, In : Lung Cancer. 101, p. 1-8 8 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Japan
Retrospective Studies
Biopsy
Epidermal Growth Factor Receptor
2015
53 Citations (Scopus)

Afatinib versus cisplatin plus pemetrexed in Japanese patients with advanced non-small cell lung cancer harboring activating EGFR mutations: Subgroup analysis of LUX-Lung 3

Kato, T., Yoshioka, H., Okamoto, I., Yokoyama, A., Hida, T., Seto, T., Kiura, K., Massey, D., Seki, Y. & Yamamoto, N., Sep 1 2015, In : Cancer Science. 106, 9, p. 1202-1211 10 p.

Research output: Contribution to journalArticle

Pemetrexed
Non-Small Cell Lung Carcinoma
Cisplatin
Lung
Mutation
10 Citations (Scopus)

Circulating hepatocyte growth factor is correlated with resistance to cetuximab in metastatic colorectal cancer

Yonesaka, K., Satoh, T., Ueda, S., Yoshida, T., Takeda, M., Shimizu, T., Okamoto, I., Nishio, K., Tamura, T. & Nakagawa, K., Mar 1 2015, In : Anticancer research. 35, 3, p. 1683-1690 8 p.

Research output: Contribution to journalArticle

Hepatocyte Growth Factor
Colorectal Neoplasms
Transforming Growth Factors
Epidermal Growth Factor Receptor
Disease-Free Survival

Clinical benefits associated with first line treatment using afatinib

Iwama, E. & Okamoto, I., Oct 20 2015, In : Japanese Journal of Lung Cancer. 55, 6, p. 866-870 5 p.

Research output: Contribution to journalReview article

Epidermal Growth Factor Receptor
Protein-Tyrosine Kinases
Therapeutics
Mutation
Paronychia
7 Citations (Scopus)

Clinical development of nintedanib for advanced non-small-cell lung cancer

Takeda, M., Okamoto, I. & Nakagawa, K., Nov 16 2015, In : Therapeutics and Clinical Risk Management. 11, p. 1701-1706 6 p.

Research output: Contribution to journalReview article

docetaxel
Non-Small Cell Lung Carcinoma
cancer
Cells
Toxicity
7 Citations (Scopus)

Combined analysis of plasma amphiregulin and heregulin predicts response to cetuximab in metastatic colorectal cancer

Yonesaka, K., Takegawa, N., Satoh, T., Ueda, H., Yoshida, T., Takeda, M., Shimizu, T., Chiba, Y., Okamoto, I., Nishio, K., Tamura, T. & Nakagawa, K., Nov 1 2015, In : PloS one. 10, 11, e0143132.

Research output: Contribution to journalArticle

Neuregulin-1
colorectal neoplasms
Colorectal Neoplasms
Plasmas
Epidermal Growth Factor Receptor
50 Citations (Scopus)

Digital PCR analysis of plasma cell-free DNA for non-invasive detection of drug resistance mechanisms in EGFR mutant NSCLC: Correlation with paired tumor samples

Ishii, H., Azuma, K., Sakai, K., Kawahara, A., Yamada, K., Tokito, T., Okamoto, I., Nishio, K. & Hoshino, T., Jan 1 2015, In : Oncotarget. 6, 31, p. 30850-30858 9 p.

Research output: Contribution to journalArticle

Plasma Cells
Epidermal Growth Factor Receptor
Drug Resistance
Non-Small Cell Lung Carcinoma
Polymerase Chain Reaction
22 Citations (Scopus)

Heterogeneity of anaplastic lymphoma kinase gene rearrangement in non-small-cell lung carcinomas: A comparative study between small biopsy and excision samples

Abe, H., Kawahara, A., Azuma, K., Taira, T., Takase, Y., Fukumitsu, C., Murata, K., Yamaguchi, T., Akiba, J., Ishii, H., Okamoto, I., Hoshino, T., Takamori, S. & Kage, M., May 30 2015, In : Journal of Thoracic Oncology. 10, 5, p. 800-805 6 p.

Research output: Contribution to journalArticle

Gene Rearrangement
Non-Small Cell Lung Carcinoma
Fluorescence In Situ Hybridization
Biopsy
Immunohistochemistry
19 Citations (Scopus)

Highly sensitive and quantitative evaluation of the EGFR T790M mutation by nanofluidic digital PCR

Iwama, E., Takayama, K., Harada, T., Okamoto, I., Ookubo, F., Kishimoto, J., Baba, E., Oda, Y. & Nakanishi, Y., Jan 1 2015, In : Oncotarget. 6, 24, p. 20466-20473 8 p.

Research output: Contribution to journalArticle

Polymerase Chain Reaction
Mutation
Alleles
Therapeutics
Neoplasms
9 Citations (Scopus)

Hypermethylation of the CpG dinucleotide in epidermal growth factor receptor codon 790: Implications for a mutational hotspot leading to the T790M mutation in non-small-cell lung cancer

Fujii, A., Harada, T., Iwama, E., Ota, K., Furuyama, K., Ijichi, K., Okamoto, T., Okamoto, I., Takayama, K. & Nakanishi, Y., May 1 2015, In : Cancer Genetics. 208, 5, p. 271-278 8 p.

Research output: Contribution to journalArticle

5-Methylcytosine
Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
Codon
Mutation

II. Development and future prospects of the third-generation EGFR-tyrosine kinase inhibitor

Sakata, S., Iwama, E. & Okamoto, I., Aug 1 2015, In : Japanese Journal of Cancer and Chemotherapy. 42, 8, p. 935-939 5 p.

Research output: Contribution to journalArticle

Protein-Tyrosine Kinases

II. Development and Future Prospects of the Third-Generation EGFR-Tyrosine Kinase Inhibitor

Sakata, S., Iwama, E. & Okamoto, I., Aug 1 2015, In : Japanese Journal of Cancer and Chemotherapy. 42, 8, p. 935-939 5 p.

Research output: Contribution to journalArticle

Drug Design
Protein Kinase Inhibitors
Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
Protein-Tyrosine Kinases
225 Citations (Scopus)

Induction of PD-L1 expression by the EML4-ALK oncoprotein and down stream signaling pathways in non-small cell lung cancer

Ota, K., Azuma, K., Kawahara, A., Hattori, S., Iwama, E., Tanizaki, J., Harada, T., Matsumoto, K., Takayama, K., Takamori, S., Kage, M., Hoshino, T., Nakanishi, Y. & Okamoto, I., Sep 1 2015, In : Clinical Cancer Research. 21, 17, p. 4014-4021 8 p.

Research output: Contribution to journalArticle

Oncogene Proteins
Non-Small Cell Lung Carcinoma
Gene Fusion
Phosphatidylinositol 3-Kinases
Cell Line