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Research Output 1998 2019

2009
48 Citations (Scopus)

Addition of S-1 to the epidermal growth factor receptor inhibitor gefitinib overcomes gefitinib resistance in non-small cell lung cancer cell lines with MET amplification

Okabe, T., Okamoto, I., Tsukioka, S., Uchida, J., Hatashita, E., Yamada, Y., Yoshida, T., Nishio, K., Fukuoka, M., Jänne, P. A. & Nakagawa, K., Feb 1 2009, In : Clinical Cancer Research. 15, 3, p. 907-913 7 p.

Research output: Contribution to journalArticle

Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
Cell Line
Thymidylate Synthase
Mutation

Cancer of unknown primary site - Current status and future direction

Ichikawa, Y., Okamoto, I. & Nakagawa, K., 2009, In : Japanese Journal of Cancer and Chemotherapy. 36, 6, p. 907-909 3 p.

Research output: Contribution to journalArticle

Neoplasms
Diagnostic Imaging
Physical Examination
Biopsy
Drug Therapy
5 Citations (Scopus)

Cisplatin and etoposide chemotherapy combined with early concurrent twice-daily thoracic radiotherapy for limited-disease small cell lung cancer in elderly patients

Okamoto, K., Okamoto, I., Takezawa, K., Tachibana, I., Fukuoka, M., Nishimura, Y. & Nakagawa, K., Oct 16 2009, In : Japanese Journal of Clinical Oncology. 40, 1, p. 54-59 6 p., hyp137.

Research output: Contribution to journalArticle

Small Cell Lung Carcinoma
Etoposide
Cisplatin
Radiotherapy
Thorax
168 Citations (Scopus)

Combined survival analysis of prospective clinical trials of gefitinib for non-small cell lung cancer with EGFR mutations

Morita, S., Okamoto, I., Kobayashi, K., Yamazaki, K., Asahina, H., Inoue, A., Hagiwara, K., Sunaga, N., Yanagitani, N., Hida, T., Yoshida, K., Hirashima, T., Yasumoto, K., Sugio, K., Mitsudomi, T., Fukuoka, M. & Nukiwa, T., Jul 1 2009, In : Clinical Cancer Research. 15, 13, p. 4493-4498 6 p.

Research output: Contribution to journalArticle

Survival Analysis
Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
Clinical Trials
Mutation
3 Citations (Scopus)

Disturbance of the growth hormone-insulin-like growth factor-1 axis associated with poor performance status in patients with solid tumors

Okamoto, I., Munakata, M., Miyazaki, M., Satoh, T., Takahata, T., Takamatsu, Y., Muto, O., Koike, K., Ishitani, K., Mukaiyama, T., Sakata, Y., Nakagawa, K. & Tamura, K., Nov 25 2009, In : Japanese journal of clinical oncology. 40, 3, p. 222-226 5 p., hyp155.

Research output: Contribution to journalArticle

Somatomedins
Growth Hormone
Neoplasms
Hormones
Insulin-Like Growth Factor Binding Protein 3
50 Citations (Scopus)

Inhibition of insulin-like growth factor 1 receptor by CP-751,871 radiosensitizes non-small cell lung cancer cells

Iwasa, T., Okamoto, I., Suzuki, M., Hatashita, E., Yamada, Y., Fukuoka, M., Ono, K. & Nakagawa, K., Aug 15 2009, In : Clinical Cancer Research. 15, 16, p. 5117-5125 9 p.

Research output: Contribution to journalArticle

Somatomedin Receptors
Non-Small Cell Lung Carcinoma
Radiation
Heterografts
Histones
15 Citations (Scopus)

Phase I/II study of S-1 plus carboplatin in patients with advanced non-small cell lung cancer

Tamura, K., Okamoto, I., Ozaki, T., Kashii, T., Takeda, K., Kobayashi, M., Matsui, K., Shibata, T., Kurata, T., Nakagawa, K. & Fukuoka, M., Aug 1 2009, In : European Journal of Cancer. 45, 12, p. 2132-2137 6 p.

Research output: Contribution to journalArticle

Carboplatin
Non-Small Cell Lung Carcinoma
Survival
Disease-Free Survival
Anemia
58 Citations (Scopus)

Phase I clinical and pharmacokinetic study of Rad001 (everolimus) administered daily to Japanese patients with advanced solid tumors

Okamoto, I., Doi, T., Ohtsu, A., Miyazaki, M., Tsuya, A., Kurei, K., Kobayashi, K. & Nakagawa, K., Sep 25 2009, In : Japanese journal of clinical oncology. 40, 1, p. 17-23 7 p., hyp120.

Research output: Contribution to journalArticle

Pharmacokinetics
Neoplasms
Esophageal Neoplasms
Safety
Stomach Neoplasms
124 Citations (Scopus)

Phase I study of YM155, a novel survivin suppressant, in patients with advanced solid tumors

Satoh, T., Okamoto, I., Miyazaki, M., Morinaga, R., Tsuya, A., Hasegawa, Y., Terashima, M., Ueda, S., Fukuoka, M., Ariyoshi, Y., Saito, T., Masuda, N., Watanabe, H., Taguchi, T., Kakihara, T., Aoyama, Y., Hashimoto, Y. & Nakagawa, K., Jun 1 2009, In : Clinical Cancer Research. 15, 11, p. 3872-3880 9 p.

Research output: Contribution to journalArticle

Maximum Tolerated Dose
Neoplasms
Pharmacokinetics
Inhibitor of Apoptosis Proteins
Safety
21 Citations (Scopus)

S-1: A new oral fluoropyrimidine in the treatment of patients with advanced non-small-cell lung cancer

Okamoto, I. & Fukuoka, M., Jan 1 2009, In : Clinical Lung Cancer. 10, 4, p. 290-294 5 p.

Research output: Contribution to journalReview article

Non-Small Cell Lung Carcinoma
irinotecan
gemcitabine
Platinum Compounds
Tegafur
61 Citations (Scopus)

Sorafenib inhibits non-small cell lung cancer cell growth by targeting B-RAF in KRAS wild-type cells and C-RAF in KRAS mutant cells

Takezawa, K., Okamoto, I., Yonesaka, K., Hatashita, E., Yamada, Y., Fukuoka, M. & Nakagawa, K., Aug 15 2009, In : Cancer Research. 69, 16, p. 6515-6521 7 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Growth
Extracellular Signal-Regulated MAP Kinases
Phosphorylation
sorafenib
58 Citations (Scopus)

SRPX2 is overexpressed in gastric cancer and promotes cellular migration and adhesion

Tamaka, K., Aran, T., Maegawa, M., Matsumoto, K., Kaneda, H., Kudo, K., Fujita, Y., Yokote, H., Yanagihara, K., Yamada, Y., Okamoto, I., Nakagawa, K. & Nishio, K., Mar 1 2009, In : International Journal of Cancer. 124, 5, p. 1072-1080 9 p.

Research output: Contribution to journalArticle

Stomach Neoplasms
Proteins
Focal Adhesion Protein-Tyrosine Kinases
HEK293 Cells
Gene Fusion

The role to be played by the specialty of tumor chemotherapy: a discussion

Eguchi, K., Tamura, K., Okamoto, I., Munakata, W. & Imamura, T., Aug 10 2009, In : Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine. 98, 8, p. 1959-1975 17 p.

Research output: Contribution to journalArticle

Palliative Care
Medicine
Drug Therapy
Neoplasms
3 Citations (Scopus)

Zoledronic acid-induced regression of multiple metastases at nonskeletal sites

Okamoto, K., Tsurutani, J., Terashima, M., Okamoto, I. & Nakagawa, K., Apr 7 2009, In : Annals of Oncology. 20, 4, p. 796-797 2 p.

Research output: Contribution to journalArticle

2010
56 Citations (Scopus)

De novo resistance to epidermal growth factor receptor-tyrosine kinase inhibitors in EGFR mutation-positive patients with non-small cell lung cancer

Takeda, M., Okamoto, I., Fujita, Y., Arao, T., Ito, H., Fukuoka, M., Nishio, K. & Nakagawa, K., Jan 1 2010, In : Journal of Thoracic Oncology. 5, 3, p. 399-400 2 p.

Research output: Contribution to journalArticle

Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
Protein-Tyrosine Kinases
Mutation
erbB-1 Genes
11 Citations (Scopus)

Dose-escalation study of pemetrexed in combination with carboplatin followed by pemetrexed maintenance therapy for advanced non-small cell lung cancer

Okamoto, I., Takeda, K., Daga, H., Miyazaki, M., Yonesaka, K., Kiyota, H., Tsurutani, J., Ueda, S., Ichikawa, Y., Takeda, M., Sekiguchi, R., Tominaga, K., Enatsu, S., Nambu, Y. & Nakagawa, K., Nov 1 2010, In : Lung Cancer. 70, 2, p. 168-173 6 p.

Research output: Contribution to journalArticle

Pemetrexed
Carboplatin
Non-Small Cell Lung Carcinoma
Therapeutics
Confidence Intervals
49 Citations (Scopus)

Effects of Src inhibitors on cell growth and epidermal growth factor receptor and MET signaling in gefitinib-resistant non-small cell lung cancer cells with acquired MET amplification

Yoshida, T., Okamoto, I., Okamoto, W., Hatashita, E., Yamada, Y., Kuwata, K., Nishio, K., Fukuoka, M., Jänne, P. A. & Nakagawa, K., Jan 1 2010, In : Cancer Science. 101, 1, p. 167-172 6 p.

Research output: Contribution to journalArticle

Growth Inhibitors
Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
gefitinib
Mutation
58 Citations (Scopus)

Enhanced anticancer effect of the combination of BIBW2992 and thymidylate synthase-targeted agents in non-small cell lung cancer with the T790M mutation of epidermal growth factor receptor

Takezawa, K., Okamoto, I., Tanizaki, J., Kuwata, K., Yamaguchi, H., Fukuoka, M., Nishio, K. & Nakagawa, K., Jun 1 2010, In : Molecular Cancer Therapeutics. 9, 6, p. 1647-1656 10 p.

Research output: Contribution to journalArticle

Thymidylate Synthase
Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
Pemetrexed
Mutation
59 Citations (Scopus)

Epidermal growth factor receptor in relation to tumor development: EGFR-targeted anticancer therapy

Okamoto, I., Jan 1 2010, In : FEBS Journal. 277, 2, p. 309-315 7 p.

Research output: Contribution to journalShort survey

Epidermal Growth Factor Receptor
Tumors
Neoplasms
Protein-Tyrosine Kinases
Therapeutics
117 Citations (Scopus)

FOXQ1 is overexpressed in colorectal cancer and enhances tumorigenicity and tumor growth

Kaneda, H., Arao, T., Tanaka, K., Tamura, D., Aomatsu, K., Kudo, K., Sakai, K., De Velasco, M. A., Matsumoto, K., Fujita, Y., Yamada, Y., Tsurutani, J., Okamoto, I., Nakagawa, K. & Nishio, K., Mar 1 2010, In : Cancer Research. 70, 5, p. 2053-2063 11 p.

Research output: Contribution to journalArticle

Colorectal Neoplasms
Growth
Neoplasms
Microarray Analysis
Gastric Mucins
2820 Citations (Scopus)

Gefitinib versus cisplatin plus docetaxel in patients with non-small-cell lung cancer harbouring mutations of the epidermal growth factor receptor (WJTOG3405): an open label, randomised phase 3 trial

Mitsudomi, T., Morita, S., Yatabe, Y., Negoro, S., Okamoto, I., Tsurutani, J., Seto, T., Satouchi, M., Tada, H., Hirashima, T., Asami, K., Katakami, N., Takada, M., Yoshioka, H., Shibata, K., Kudoh, S., Shimizu, E., Saito, H., Toyooka, S., Nakagawa, K. & 1 others, Fukuoka, M., Feb 1 2010, In : The Lancet Oncology. 11, 2, p. 121-128 8 p.

Research output: Contribution to journalArticle

docetaxel
Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
Cisplatin
Mutation
48 Citations (Scopus)

Identification of c-Src as a potential therapeutic target for gastric cancer and of MET activation as a cause of resistance to c-Src inhibition

Okamoto, W., Okamoto, I., Yoshida, T., Okamoto, K., Takezawa, K., Hatashita, E., Yamada, Y., Kuwata, K., Arao, T., Yanagihara, K., Fukuoka, M., Nishio, K. & Nakagawa, K., May 1 2010, In : Molecular Cancer Therapeutics. 9, 5, p. 1188-1197 10 p.

Research output: Contribution to journalArticle

Stomach Neoplasms
Cell Line
Extracellular Signal-Regulated MAP Kinases
Therapeutics
Apoptosis
27 Citations (Scopus)

Identification of thymidylate synthase as a potential therapeutic target for lung cancer

Takezawa, K., Okamoto, I., Tsukioka, S., Uchida, J., Kiniwa, M., Fukuoka, M. & Nakagawa, K., Jul 27 2010, In : British journal of cancer. 103, 3, p. 354-361 8 p.

Research output: Contribution to journalArticle

Thymidylate Synthase
Lung Neoplasms
Therapeutics
RNA Interference
X-Linked Inhibitor of Apoptosis Protein
52 Citations (Scopus)

Marked anti-tumour activity of the combination of YM155, a novel survivin suppressant, and platinum-based drugs

Iwasa, T., Okamoto, I., Takezawa, K., Yamanaka, K., Nakahara, T., Kita, A., Koutoku, H., Sasamata, M., Hatashita, E., Yamada, Y., Kuwata, K., Fukuoka, M. & Nakagawa, K., Jun 29 2010, In : British journal of cancer. 103, 1, p. 36-42 7 p.

Research output: Contribution to journalArticle

Platinum Compounds
Platinum
Pharmaceutical Preparations
Neoplasms
Heterografts
32 Citations (Scopus)

Phase i clinical and pharmacokinetic study of sorafenib in combination with carboplatin and paclitaxel in patients with advanced non-small cell lung cancer

Okamoto, I., Miyazaki, M., Morinaga, R., Kaneda, H., Ueda, S., Hasegawa, Y., Satoh, T., Kawada, A., Fukuoka, M., Fukino, K., Tanigawa, T. & Nakagawa, K., Dec 1 2010, In : Investigational New Drugs. 28, 6, p. 844-853 10 p.

Research output: Contribution to journalArticle

Carboplatin
Paclitaxel
Non-Small Cell Lung Carcinoma
Pharmacokinetics
Area Under Curve
14 Citations (Scopus)

Phase I clinical and pharmacokinetic study of the glucose-conjugated cytotoxic agent d-19575 (glufosfamide) in patients with solid tumors

Shimizu, T., Okamoto, I., Tamura, K., Satoh, T., Miyazaki, M., Akashi, Y., Ozaki, T., Fukuoka, M. & Nakagawa, K., Jan 1 2010, In : Cancer Chemotherapy and Pharmacology. 65, 2, p. 243-250 8 p.

Research output: Contribution to journalArticle

Ifosfamide
Pharmacokinetics
Cytotoxins
gemcitabine
Toxicity
122 Citations (Scopus)

Phase III trial comparing oral S-1 plus carboplatin with paclitaxel plus carboplatin in chemotherapy-naïve patients with advanced non-small-cell lung cancer: Results of a west Japan oncology group study

Okamoto, I., Yoshioka, H., Morita, S., Ando, M., Takeda, K., Seto, T., Yamamoto, N., Saka, H., Asami, K., Hirashima, T., Kudoh, S., Satouchi, M., Ikeda, N., Iwamoto, Y., Sawa, T., Miyazaki, M., Tamura, K., Kurata, T., Fukuoka, M. & Nakagawa, K., Dec 20 2010, In : Journal of Clinical Oncology. 28, 36, p. 5240-5246 7 p.

Research output: Contribution to journalArticle

Carboplatin
Paclitaxel
Non-Small Cell Lung Carcinoma
Japan
Drug Therapy
14 Citations (Scopus)

Phase II trial of amrubicin for second-line treatment of advanced non-small cell lung cancer: Results of the west japan thoracic oncology group trial (WJTOG0401)

Kaneda, H., Okamoto, I., Hayashi, H., Yoshioka, H., Miyazaki, M., Kudoh, S., Kimura, T., Sugiura, T., Sawa, T., Takeda, K., Iwamoto, Y., Satouchi, M., Akita, K., Saito, H., Goto, I., Shibata, K., Fukuoka, M. & Nakagawa, K., Jan 1 2010, In : Journal of Thoracic Oncology. 5, 1, p. 105-109 5 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Japan
Thorax
Febrile Neutropenia
Topoisomerase II Inhibitors
85 Citations (Scopus)

Phase I safety, pharmacokinetic, and biomarker study of BIBF 1120, an oral triple tyrosine kinase inhibitor in patients with advanced solid tumors

Okamoto, I., Kaneda, H., Satoh, T., Okamoto, W., Miyazaki, M., Morinaga, R., Ueda, S., Terashima, M., Tsuya, A., Sarashina, A., Konishi, K., Arao, T., Nishio, K., Kaiser, R. & Nakagawa, K., Oct 1 2010, In : Molecular Cancer Therapeutics. 9, 10, p. 2825-2833 9 p.

Research output: Contribution to journalArticle

Protein-Tyrosine Kinases
Pharmacokinetics
Biomarkers
Safety
Neoplasms
150 Citations (Scopus)

Randomized phase III trial of platinum-doublet chemotherapy followed by gefitinib compared with continued platinum-doublet chemotherapy in Japanese patients with advanced non-small-cell lung cancer: Results of a West Japan Thoracic Oncology Group Trial (WJTOG0203)

Takeda, K., Hida, T., Sato, T., Ando, M., Seto, T., Satouchi, M., Ichinose, Y., Katakami, N., Yamamoto, N., Kudoh, S., Sasaki, J., Matsui, K., Takayama, K., Kashii, T., Iwamoto, Y., Sawa, T., Okamoto, I., Kurata, T., Nakagawa, K. & Fukuoka, M., Feb 10 2010, In : Journal of Clinical Oncology. 28, 5, p. 753-760 8 p.

Research output: Contribution to journalArticle

Platinum
Non-Small Cell Lung Carcinoma
Japan
Thorax
Drug Therapy
10 Citations (Scopus)

Retreatment of recurrent malignant pleural mesothelioma with cisplatin and pemetrexed

Hayashi, H., Okamoto, I., Ichikawa, Y., Miyazaki, M., Yoshioka, H., Kunimasa, K. & Nakagawa, K., Oct 2010, In : International Journal of Clinical Oncology. 15, 5, p. 497-499 3 p.

Research output: Contribution to journalArticle

Pemetrexed
Retreatment
Cisplatin
Drug Therapy
Drug Combinations
59 Citations (Scopus)

Role of survivin in EGFR inhibitor-induced apoptosis in non-small cell lung cancers positive for EGFR mutations

Okamoto, K., Okamoto, I., Okamoto, W., Tanaka, K., Takezawa, K., Kuwata, K., Yamaguchi, H., Nishio, K. & Nakagawa, K., Dec 15 2010, In : Cancer Research. 70, 24, p. 10402-10410 9 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Apoptosis
Mutation
Epidermal Growth Factor Receptor
Protein-Tyrosine Kinases
21 Citations (Scopus)

Successful treatment with erlotinib after gefitinib-induced severe interstitial lung disease

Takeda, M., Okamoto, I., Makimura, C., Fukuoka, M. & Nakagawa, K., Jan 1 2010, In : Journal of Thoracic Oncology. 5, 7, p. 1103-1104 2 p.

Research output: Contribution to journalArticle

Antineoplastic Combined Chemotherapy Protocols
Quinazolines
X Ray Computed Tomography
Interstitial Lung Diseases
Lung Neoplasms
26 Citations (Scopus)

Successful treatment with erlotinib after gefitinib-related severe hepatotoxicity

Takeda, M., Okamoto, I., Fukuoka, M. & Nakagawa, K., Jun 10 2010, In : Journal of Clinical Oncology. 28, 17, p. e273-e274

Research output: Contribution to journalArticle

Quinazolines
Chemical and Drug Induced Liver Injury
Liver Neoplasms
Non-Small Cell Lung Carcinoma
Antineoplastic Agents
38 Citations (Scopus)

Synergistic antitumor effect of S-1 and HER2-targeting agents in gastric cancer with HER2 amplification

Tanizaki, J., Okamoto, I., Takezawa, K., Tsukioka, S., Uchida, J., Kiniwa, M., Fukuoka, M. & Nakagawa, K., May 1 2010, In : Molecular Cancer Therapeutics. 9, 5, p. 1198-1207 10 p.

Research output: Contribution to journalArticle

Stomach Neoplasms
Fluorouracil
Thymidylate Synthase
human ERBB2 protein
Down-Regulation
61 Citations (Scopus)

TAK-701, a humanized monoclonal antibody to hepatocyte growth factor, reverses gefitinib resistance induced by tumor-derived HGF in non-small cell lung cancer with an EGFR mutation

Okamoto, W., Okamoto, I., Tanaka, K., Hatashita, E., Yamada, Y., Kuwata, K., Yamaguchi, H., Arao, T., Nishio, K., Fukuoka, M., Jänne, P. A. & Nakagawa, K., Oct 1 2010, In : Molecular Cancer Therapeutics. 9, 10, p. 2785-2792 8 p.

Research output: Contribution to journalArticle

Antibodies, Monoclonal, Humanized
Hepatocyte Growth Factor
Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
Mutation
20 Citations (Scopus)
Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
Protein-Tyrosine Kinases
Mutation
Therapeutics
2011
342 Citations (Scopus)

Activation of ERBB2 signaling causes resistance to the EGFR-directed therapeutic antibody cetuximab

Yonesaka, K., Zejnullahu, K., Okamoto, I., Satoh, T., Cappuzzo, F., Souglakos, J., Ercan, D., Rogers, A., Roncalli, M., Takeda, M., Fujisaka, Y., Philips, J., Shimizu, T., Maenishi, O., Cho, Y., Sun, J., Destro, A., Taira, K., Takeda, K., Okabe, T. & 12 others, Swanson, J., Itoh, H., Takada, M., Lifshits, E., Okuno, K., Engelman, J. A., Shivdasani, R. A., Nishio, K., Fukuoka, M., Varella-Garcia, M., Nakagawa, K. & Jänne, P. A., Sep 7 2011, In : Science Translational Medicine. 3, 99

Research output: Contribution to journalArticle

Antibodies
Neuregulin-1
Therapeutics
Mitogen-Activated Protein Kinase 3
Mitogen-Activated Protein Kinase 1

Activation of ERBB2 signaling causes resistance to the EGFR-directed therapeutic antibody cetuximab.

Yonesaka, K., Zejnullahu, K., Okamoto, I., Satoh, T., Cappuzzo, F., Souglakos, J., Ercan, D., Rogers, A., Roncalli, M., Takeda, M., Fujisaka, Y., Philips, J., Shimizu, T., Maenishi, O., Cho, Y., Sun, J., Destro, A., Taira, K., Takeda, K., Okabe, T. & 12 others, Swanson, J., Itoh, H., Takada, M., Lifshits, E., Okuno, K., Engelman, J. A., Shivdasani, R. A., Nishio, K., Fukuoka, M., Varella-Garcia, M., Nakagawa, K. & Jänne, P. A., Sep 7 2011, In : Science Translational Medicine. 3, 99

Research output: Contribution to journalArticle

Antibodies
Neuregulin-1
Therapeutics
Mitogen-Activated Protein Kinase 3
Mitogen-Activated Protein Kinase 1
44 Citations (Scopus)

Activin A inhibits vascular endothelial cell growth and suppresses tumour angiogenesis in gastric cancer

Kaneda, H., Arao, T., Matsumoto, K., De Velasco, M. A., Tamura, D., Aomatsu, K., Kudo, K., Sakai, K., Nagai, T., Fujita, Y., Tanaka, K., Yanagihara, K., Yamada, Y., Okamoto, I., Nakagawa, K. & Nishio, K., Oct 11 2011, In : British journal of cancer. 105, 8, p. 1210-1217 8 p.

Research output: Contribution to journalArticle

Stomach Neoplasms
Endothelial Cells
Human Umbilical Vein Endothelial Cells
Growth
Neoplasms
26 Citations (Scopus)

Differential roles of STAT3 depending on the mechanism of STAT3 activation in gastric cancer cells

Okamoto, W., Okamoto, I., Arao, T., Yanagihara, K., Nishio, K. & Nakagawa, K., Jul 26 2011, In : British journal of cancer. 105, 3, p. 407-412 6 p.

Research output: Contribution to journalArticle

STAT3 Transcription Factor
Transcriptional Activation
Stomach Neoplasms
Cell Movement
Protein-Tyrosine Kinases
67 Citations (Scopus)

Differential roles of trans-phosphorylated EGFR, HER2, HER3, and RET as heterodimerisation partners of MET in lung cancer with MET amplification

Tanizaki, J., Okamoto, I., Sakai, K. & Nakagawa, K., Sep 6 2011, In : British journal of cancer. 105, 6, p. 807-813 7 p.

Research output: Contribution to journalArticle

Epidermal Growth Factor Receptor
Lung Neoplasms
Receptor Protein-Tyrosine Kinases
Immunoprecipitation
Cell Migration Assays

Erlotinib in non-small cell lung cancer

Takeda, M. & Okamoto, I., Jan 1 2011, In : Japanese Journal of Cancer and Chemotherapy. 38, 6, p. 896-900 5 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Protein-Tyrosine Kinases
Quinazolines
Mutation
Disease-Free Survival
25 Citations (Scopus)

High-dose dexamethasone plus antihistamine prevents colorectal cancer patients treated with modified FOLFOX6 from hypersensitivity reactions induced by oxaliplatin

Kidera, Y., Satoh, T., Ueda, S., Okamoto, W., Okamoto, I., Fumita, S., Yonesaka, K., Hayashi, H., Makimura, C., Okamoto, K., Kiyota, H., Tsurutani, J., Miyazaki, M., Yoshinaga, M., Fujiwara, K., Yamazoe, Y., Moriyama, K., Tsubaki, M., Chiba, Y., Nishida, S. & 1 others, Nakagawa, K., Jun 1 2011, In : International Journal of Clinical Oncology. 16, 3, p. 244-249 6 p.

Research output: Contribution to journalArticle

oxaliplatin
Histamine Antagonists
Dexamethasone
Colorectal Neoplasms
Hypersensitivity
9 Citations (Scopus)

Malignant pleural effusion from lung adenocarcinoma treated by gefitinib

Kubo, A., Koh, Y., Kawaguchi, T., Isa, S. I., Okamoto, I., Fukuoka, J., Kusunoki, Y., Kitaichi, M., Takada, M. & Nakagawa, K., Apr 12 2011, In : Internal Medicine. 50, 7, p. 745-748 4 p.

Research output: Contribution to journalArticle

Malignant Pleural Effusion
Apoptosis
Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
Drainage
93 Citations (Scopus)

MET tyrosine kinase inhibitor crizotinib (PF-02341066) shows differential antitumor effects in non-small cell lung cancer according to MET alterations

Tanizaki, J., Okamoto, I., Okamoto, K., Takezawa, K., Kuwata, K., Yamaguchi, H. & Nakagawa, K., Jan 1 2011, In : Journal of Thoracic Oncology. 6, 10, p. 1624-1631 8 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Protein-Tyrosine Kinases
Mutation
Lung Neoplasms
Apoptosis
15 Citations (Scopus)

Phase I study of dasatinib (BMS-354825) in Japanese patients with solid tumors

Takahashi, S., Miyazaki, M., Okamoto, I., Ito, Y., Ueda, K., Seriu, T., Nakagawa, K. & Hatake, K., Nov 1 2011, In : Cancer Science. 102, 11, p. 2058-2064 7 p.

Research output: Contribution to journalArticle

Maximum Tolerated Dose
Neoplasms
Pleural Effusion
Fatigue
Anemia
103 Citations (Scopus)

Role of ERK-BIM and STAT3-survivin signaling pathways in ALK inhibitor-induced apoptosis in EML4-ALK-positive lung cancer

Takezawa, K., Okamoto, I., Nishio, K., Jänne, P. A. & Nakagawa, K., Apr 15 2011, In : Clinical Cancer Research. 17, 8, p. 2140-2148 9 p.

Research output: Contribution to journalArticle

Extracellular Signal-Regulated MAP Kinases
Lung Neoplasms
Apoptosis
NIH 3T3 Cells
Up-Regulation
44 Citations (Scopus)

Roles of BIM induction and survivin downregulation in lapatinib-induced apoptosis in breast cancer cells with HER2 amplification

Tanizaki, J., Okamoto, I., Fumita, S., Okamoto, W., Nishio, K. & Nakagawa, K., Sep 29 2011, In : Oncogene. 30, 39, p. 4097-4106 10 p.

Research output: Contribution to journalArticle

Phosphatidylinositol 3-Kinase
Down-Regulation
Apoptosis
Breast Neoplasms
Mutation
28 Citations (Scopus)

S-1 plus cisplatin with concurrent radiotherapy for locally advanced non-small cell lung cancer: a multi-institutional phase II trial (West Japan Thoracic Oncology Group 3706).

Ichinose, Y., Seto, T., Sasaki, T., Yamanaka, T., Okamoto, I., Takeda, K., Tanaka, M., Katakami, N., Sawa, T., Kudoh, S., Saka, H., Nishimura, Y., Nakagawa, K. & Fukuoka, M., Jan 1 2011, In : Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer. 6, 12, p. 2069-2075 7 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Cisplatin
Japan
Radiotherapy
Thorax