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Research Output 1998 2019

Clinical significance of monitoring EGFR mutation in plasma using multiplexed digital PCR in EGFR mutated patients treated with afatinib (West Japan Oncology Group 8114LTR study)

Akamatsu, H., Koh, Y., Okamoto, I., Fujimoto, D., Bessho, A., Azuma, K., Morita, S., Yamamoto, N. & Nakagawa, K., May 1 2019, In : Lung Cancer. 131, p. 128-133 6 p.

Research output: Contribution to journalArticle

Open Access
Epidermal Growth Factor Receptor
Japan
Polymerase Chain Reaction
Mutation
Non-Small Cell Lung Carcinoma
5 Citations (Scopus)

Clinical significance of PD-L1 expression in brain metastases from non-small cell lung cancer

Takamori, S., Toyokawa, G., Okamoto, I., Takada, K., Kinoshita, F., Kozuma, Y., Matsubara, T., Haratake, N., Akamine, T., Mukae, N., Hirai, F., Tagawa, T., Oda, Y., Iwaki, T., Iihara, K., Nakanishi, Y. & Maehara, Y., Jan 1 2018, In : Anticancer research. 38, 1, p. 553-557 5 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Cell Death
Neoplasm Metastasis
Ligands
Brain
32 Citations (Scopus)

CNS response to osimertinib versus standard epidermal growth factor receptor tyrosine kinase inhibitors in patients with untreated EGFR-mutated advanced non-small-cell lung cancer

Reungwetwattana, T., Nakagawa, K., Cho, B. C., Cobo, M., Cho, E. K., Bertolini, A., Bohnet, S., Zhou, C., Lee, K. H., Nogami, N., Okamoto, I., Leighl, N., Hodge, R., McKeown, A., Brown, A. P., Rukazenkov, Y., Ramalingam, S. S. & Vansteenkiste, J., Nov 20 2018, In : Journal of Clinical Oncology. 36, 33, p. 3290-3297 8 p.

Research output: Contribution to journalArticle

Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
Protein-Tyrosine Kinases
osimertinib
Disease-Free Survival
7 Citations (Scopus)

Combined analysis of plasma amphiregulin and heregulin predicts response to cetuximab in metastatic colorectal cancer

Yonesaka, K., Takegawa, N., Satoh, T., Ueda, H., Yoshida, T., Takeda, M., Shimizu, T., Chiba, Y., Okamoto, I., Nishio, K., Tamura, T. & Nakagawa, K., Nov 1 2015, In : PloS one. 10, 11, e0143132.

Research output: Contribution to journalArticle

Neuregulin-1
colorectal neoplasms
Colorectal Neoplasms
Plasmas
Epidermal Growth Factor Receptor
32 Citations (Scopus)

Combined effect of ALK and MEK inhibitors in EML4-ALK-positive non-small-cell lung cancer cells

Tanizaki, J., Okamoto, I., Takezawa, K., Sakai, K., Azuma, K., Kuwata, K., Yamaguchi, H., Hatashita, E., Nishio, K., Janne, P. A. & Nakagawa, K., Feb 14 2012, In : British journal of cancer. 106, 4, p. 763-767 5 p.

Research output: Contribution to journalArticle

Mitogen-Activated Protein Kinase Kinases
Non-Small Cell Lung Carcinoma
MAP Kinase Signaling System
Apoptosis
Phosphorylation
168 Citations (Scopus)

Combined survival analysis of prospective clinical trials of gefitinib for non-small cell lung cancer with EGFR mutations

Morita, S., Okamoto, I., Kobayashi, K., Yamazaki, K., Asahina, H., Inoue, A., Hagiwara, K., Sunaga, N., Yanagitani, N., Hida, T., Yoshida, K., Hirashima, T., Yasumoto, K., Sugio, K., Mitsudomi, T., Fukuoka, M. & Nukiwa, T., Jul 1 2009, In : Clinical Cancer Research. 15, 13, p. 4493-4498 6 p.

Research output: Contribution to journalArticle

Survival Analysis
Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
Clinical Trials
Mutation
2 Citations (Scopus)

Combined therapy with epidermal growth factor receptor tyrosine kinase inhibitors for non–small cell lung cancer

Iwama, E., Nakanishi, Y. & Okamoto, I., Mar 4 2018, In : Expert Review of Anticancer Therapy. 18, 3, p. 267-276 10 p.

Research output: Contribution to journalReview article

Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
Protein-Tyrosine Kinases
Mutation
Therapeutics
86 Citations (Scopus)

Constitutively active forms of c-Jun NH2-terminal kinase are expressed in primary glial tumors

Tsuiki, H., Tnani, M., Okamoto, I., Kenyon, L. C., Emlet, D. R., Holgado-Madruga, M., Lanham, I. S., Joynes, C. J., Vo, K. T. & Wong, A. J., Jan 1 2003, In : Cancer Research. 63, 1, p. 250-255 6 p.

Research output: Contribution to journalArticle

JNK Mitogen-Activated Protein Kinases
Neuroglia
Protein Isoforms
Neoplasms
Phosphotransferases
53 Citations (Scopus)

CRIPTO1 expression in EGFR-mutant NSCLC elicits intrinsic EGFR-inhibitor resistance

Park, K. S., Raffeld, M., Moon, Y. W., Xi, L., Bianco, C., Pham, T., Lee, L. C., Mitsudomi, T., Yatabe, Y., Okamoto, I., Subramaniam, D., Mok, T., Rosell, R., Luo, J., Salomon, D. S., Wang, Y. & Giaccone, G., Jul 1 2014, In : Journal of Clinical Investigation. 124, 7, p. 3003-3015 13 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
MicroRNAs
Epithelial-Mesenchymal Transition
Protein-Tyrosine Kinases
Mutation
3 Citations (Scopus)

Current status and future perspectives of cooperative study groups for lung cancer in Japan

Kawano, Y., Okamoto, I., Fukuda, H., Ohe, Y., Nakamura, S., Nakagawa, K., Hotta, K., Kiura, K., Takiguchi, Y., Saka, H., Okamoto, H., Takayama, K., Semba, H., Kobayashi, K., Kenmotsu, H., Tsuboi, M., Yamamoto, N., Nukiwa, T. & Nakanishi, Y., Nov 1 2014, In : Respiratory Investigation. 52, 6, p. 339-347 9 p.

Research output: Contribution to journalReview article

Lung Neoplasms
Japan
Clinical Trials
Research Personnel
Therapeutics
18 Citations (Scopus)

Cystic brain metastasis in non-small-cell lung cancer with ALK rearrangement

Hayashi, H., Okamoto, I., Tanizaki, J., Tanaka, K., Okuda, T., Kato, A., Nishimura, Y. & Nakagawa, K., Jan 1 2014, In : Journal of Clinical Oncology. 32, 36, p. e122-e124 A31.

Research output: Contribution to journalArticle

Gene Rearrangement
Receptor Protein-Tyrosine Kinases
Non-Small Cell Lung Carcinoma
Brain Neoplasms
Cysts
56 Citations (Scopus)

De novo resistance to epidermal growth factor receptor-tyrosine kinase inhibitors in EGFR mutation-positive patients with non-small cell lung cancer

Takeda, M., Okamoto, I., Fujita, Y., Arao, T., Ito, H., Fukuoka, M., Nishio, K. & Nakagawa, K., Jan 1 2010, In : Journal of Thoracic Oncology. 5, 3, p. 399-400 2 p.

Research output: Contribution to journalArticle

Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
Protein-Tyrosine Kinases
Mutation
erbB-1 Genes
86 Citations (Scopus)

Deregulation and Mislocalization of the Cytokinesis Regulator ECT2 Activate the Rho Signaling Pathways Leading to Malignant Transformation

Saito, S., Liu, X. F., Kamijo, K., Raziuddin, R., Tatsumoto, T., Okamoto, I., Chen, X., Lee, C. C., Lorenzi, M. V., Ohara, N. & Miki, T., Feb 20 2004, In : Journal of Biological Chemistry. 279, 8, p. 7169-7179 11 p.

Research output: Contribution to journalArticle

rho GTP-Binding Proteins
Cytokinesis
Deregulation
Nuclear Localization Signals
Guanine Nucleotide Exchange Factors
2 Citations (Scopus)

Detection of identical T cell clones in peritumoral pleural effusion and pneumonitis lesions in a cancer patient during immune-checkpoint blockade

Tanaka, K., Yanagihara, T., Ikematsu, Y., Inoue, H., Ota, K., Kashiwagi, E., Suzuki, K., Hamada, N., Takeuchi, A., Tatsugami, K., Eto, M., Ijichi, K., Oda, Y., Otsubo, K., Yoneshima, Y., Iwama, E., Nakanishi, Y. & Okamoto, I., Jul 17 2018, In : Oncotarget. 9, 55, p. 30587-30593 7 p.

Research output: Contribution to journalArticle

Bronchoalveolar Lavage Fluid
Pleural Effusion
Pneumonia
Clone Cells
T-Cell Antigen Receptor
30 Citations (Scopus)

Development of anaplastic lymphoma kinase (ALK) inhibitors and molecular diagnosis in ALK rearrangement-positive lung cancer

Iwama, E., Okamoto, I., Harada, T., Takayama, K. & Nakanishi, Y., Mar 5 2014, In : OncoTargets and Therapy. 7, p. 375-385 11 p.

Research output: Contribution to journalReview article

Lung Neoplasms
Non-Small Cell Lung Carcinoma
anaplastic lymphoma kinase
United States Food and Drug Administration
Oncogenes
1 Citation (Scopus)

Development of leptomeningeal carcinomatosis during a marked response of brain metastases to pembrolizumab in a patient with non-small-cell lung cancer

Otsubo, K., Seki, N., Nakanishi, Y. & Okamoto, I., Mar 1 2018, In : Annals of Oncology. 29, 3, p. 780-781 2 p.

Research output: Contribution to journalLetter

Meningeal Carcinomatosis
Non-Small Cell Lung Carcinoma
Neoplasm Metastasis
Brain
pembrolizumab
117 Citations (Scopus)

Differential constitutive activation of the epidermal growth factor receptor in non-small cell lung cancer cells bearing EGFR gene mutation and amplification

Okabe, T., Okamoto, I., Tamura, K., Terashima, M., Yoshida, T., Satoh, T., Takada, M., Fukuoka, M. & Nakagawa, K., Mar 1 2007, In : Cancer Research. 67, 5, p. 2046-2053 8 p.

Research output: Contribution to journalArticle

erbB-1 Genes
Gene Amplification
Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
Mutation
26 Citations (Scopus)

Differential roles of STAT3 depending on the mechanism of STAT3 activation in gastric cancer cells

Okamoto, W., Okamoto, I., Arao, T., Yanagihara, K., Nishio, K. & Nakagawa, K., Jul 26 2011, In : British journal of cancer. 105, 3, p. 407-412 6 p.

Research output: Contribution to journalArticle

STAT3 Transcription Factor
Transcriptional Activation
Stomach Neoplasms
Cell Movement
Protein-Tyrosine Kinases
67 Citations (Scopus)

Differential roles of trans-phosphorylated EGFR, HER2, HER3, and RET as heterodimerisation partners of MET in lung cancer with MET amplification

Tanizaki, J., Okamoto, I., Sakai, K. & Nakagawa, K., Sep 6 2011, In : British journal of cancer. 105, 6, p. 807-813 7 p.

Research output: Contribution to journalArticle

Epidermal Growth Factor Receptor
Lung Neoplasms
Receptor Protein-Tyrosine Kinases
Immunoprecipitation
Cell Migration Assays
57 Citations (Scopus)

Diffuse alveolar damage after ZD1839 therapy in a patient with non-small cell lung cancer

Okamoto, I., Fujii, K., Matsumoto, M., Terasaki, Y., Kihara, N., Kohrogi, H. & Suga, M., Jun 1 2003, In : Lung Cancer. 40, 3, p. 339-342 4 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Therapeutics
Lung
X Ray Computed Tomography
Epidermal Growth Factor Receptor
46 Citations (Scopus)

Digital PCR analysis of plasma cell-free DNA for non-invasive detection of drug resistance mechanisms in EGFR mutant NSCLC: Correlation with paired tumor samples

Ishii, H., Azuma, K., Sakai, K., Kawahara, A., Yamada, K., Tokito, T., Okamoto, I., Nishio, K. & Hoshino, T., Jan 1 2015, In : Oncotarget. 6, 31, p. 30850-30858 9 p.

Research output: Contribution to journalArticle

Plasma Cells
Epidermal Growth Factor Receptor
Drug Resistance
Non-Small Cell Lung Carcinoma
Polymerase Chain Reaction
14 Citations (Scopus)

Discrepancy in programmed cell death-ligand 1 between primary and metastatic non-small cell lung cancer

Takamori, S., Toyokawa, G., Okamoto, I., Takada, K., Kozuma, Y., Matsubara, T., Haratake, N., Akamine, T., Katsura, M., Mukae, N., Shoji, F., Okamoto, T., Oda, Y., Iwaki, T., Iihara, K., Nakanishi, Y. & Maehara, Y., Aug 1 2017, In : Anticancer research. 37, 8, p. 4223-4228 6 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Cell Death
Ligands
Radiotherapy
Brain
3 Citations (Scopus)

Disturbance of the growth hormone-insulin-like growth factor-1 axis associated with poor performance status in patients with solid tumors

Okamoto, I., Munakata, M., Miyazaki, M., Satoh, T., Takahata, T., Takamatsu, Y., Muto, O., Koike, K., Ishitani, K., Mukaiyama, T., Sakata, Y., Nakagawa, K. & Tamura, K., Nov 25 2009, In : Japanese journal of clinical oncology. 40, 3, p. 222-226 5 p., hyp155.

Research output: Contribution to journalArticle

Somatomedins
Growth Hormone
Neoplasms
Hormones
Insulin-Like Growth Factor Binding Protein 3
11 Citations (Scopus)

Dose-escalation study of pemetrexed in combination with carboplatin followed by pemetrexed maintenance therapy for advanced non-small cell lung cancer

Okamoto, I., Takeda, K., Daga, H., Miyazaki, M., Yonesaka, K., Kiyota, H., Tsurutani, J., Ueda, S., Ichikawa, Y., Takeda, M., Sekiguchi, R., Tominaga, K., Enatsu, S., Nambu, Y. & Nakagawa, K., Nov 1 2010, In : Lung Cancer. 70, 2, p. 168-173 6 p.

Research output: Contribution to journalArticle

Pemetrexed
Carboplatin
Non-Small Cell Lung Carcinoma
Therapeutics
Confidence Intervals
17 Citations (Scopus)

Down-regulation of survivin by ultraviolet C radiation is dependent on p53 and results in G2-M arrest in A549 cells

Ikeda, M., Okamoto, I., Tamura, K., Satoh, T., Yonesaka, K., Fukuoka, M. & Nakagawa, K., Apr 18 2007, In : Cancer Letters. 248, 2, p. 292-298 7 p.

Research output: Contribution to journalArticle

Down-Regulation
Radiation
DNA Damage
RNA Interference
Lung Neoplasms
2 Citations (Scopus)

Durable response to nivolumab in a lung adenocarcinoma patient with idiopathic pulmonary fibrosis

Ide, M., Tanaka, K., Sunami, S., Asoh, T., Maeyama, T., Tsuruta, N., Nakanishi, Y. & Okamoto, I., Nov 1 2018, In : Thoracic Cancer. 9, 11, p. 1519-1521 3 p.

Research output: Contribution to journalArticle

Idiopathic Pulmonary Fibrosis
Non-Small Cell Lung Carcinoma
Pleurisy
Respiratory Function Tests
Neoplasms
11 Citations (Scopus)
Non-Small Cell Lung Carcinoma
Therapeutics
Oncogenes
Protein-Tyrosine Kinases
MAP4
71 Citations (Scopus)

Effect of dose adjustment on the safety and efficacy of afatinib for EGFR mutation-positive lung adenocarcinoma: Post hoc analyses of the randomized LUX-Lung 3 and 6 trials

Yang, J. C. H., Sequist, L. V., Zhou, C., Schuler, M., Geater, S. L., Mok, T., Hu, C. P., Yamamoto, N., Feng, J., O'Byrne, K., Lu, S., Hirsh, V., Huang, Y., Sebastian, M., Okamoto, I., Dickgreber, N., Shah, R., Märten, A., Massey, D., Wind, S. & 1 others, Wu, Y. L., Jan 1 2016, In : Annals of Oncology. 27, 11, p. 2103-2110 8 p.

Research output: Contribution to journalArticle

Safety
Lung
Mutation
Disease-Free Survival
Non-Small Cell Lung Carcinoma
49 Citations (Scopus)

Effects of Src inhibitors on cell growth and epidermal growth factor receptor and MET signaling in gefitinib-resistant non-small cell lung cancer cells with acquired MET amplification

Yoshida, T., Okamoto, I., Okamoto, W., Hatashita, E., Yamada, Y., Kuwata, K., Nishio, K., Fukuoka, M., Jänne, P. A. & Nakagawa, K., Jan 1 2010, In : Cancer Science. 101, 1, p. 167-172 6 p.

Research output: Contribution to journalArticle

Growth Inhibitors
Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
gefitinib
Mutation
39 Citations (Scopus)

Efficacy and safety analysis according to histology for s-1 in combination with carboplatin as first-line chemotherapy in patients with advanced non-small-cell lung cancer: Updated results of the west japan oncology group lets study

Yoshioka, H., Okamoto, I., Morita, S., Ando, M., Takeda, K., Seto, T., Yamamoto, N., Saka, H., Atagi, S., Hirashima, T., Kudoh, S., Satouchi, M., Ikeda, N., Iwamoto, Y., Sawa, T., Nakanishi, Y. & Nakagawa, K., May 1 2013, In : Annals of Oncology. 24, 5, p. 1326-1331 6 p., mds629.

Research output: Contribution to journalArticle

Carboplatin
Non-Small Cell Lung Carcinoma
Histology
Japan
Safety
26 Citations (Scopus)

Efficacy and safety of weekly nab-paclitaxel plus carboplatin in patients with advanced non-small cell lung cancer

Satouchi, M., Okamoto, I., Sakai, H., Yamamoto, N., Ichinose, Y., Ohmatsu, H., Nogami, N., Takeda, K., Mitsudomi, T., Kasahara, K. & Negoro, S., Jul 1 2013, In : Lung Cancer. 81, 1, p. 97-101 5 p.

Research output: Contribution to journalArticle

Carboplatin
Non-Small Cell Lung Carcinoma
Safety
Paclitaxel
Thrombocytopenia
37 Citations (Scopus)

Efficacy of the tyrosine kinase inhibitor gefitinib in a patient with metastatic small cell lung cancer

Araki, J., Okamoto, I., Suto, R., Ichikawa, Y. & Sasaki, J. I., Jan 1 2005, In : Lung Cancer. 48, 1, p. 141-144 4 p.

Research output: Contribution to journalArticle

Small Cell Lung Carcinoma
Protein-Tyrosine Kinases
Therapeutics
gefitinib
Epidermal Growth Factor Receptor

EGFR

Okamoto, K. & Okamoto, I., Dec 1 2012, In : Respiration and Circulation. 60, 12, p. 1215-1220 6 p.

Research output: Contribution to journalReview article

86 Citations (Scopus)

EGFR mutation in gefitinib-responsive small-cell lung cancer [4]

Okamoto, I., Araki, J., Suto, R., Shimada, M., Nakagawa, K. & Fukuoka, M., Jun 1 2006, In : Annals of Oncology. 17, 6, p. 1028-1029 2 p.

Research output: Contribution to journalLetter

Quinazolines
Small Cell Carcinoma
Small Cell Lung Carcinoma
Epidermal Growth Factor Receptor
Antineoplastic Agents
86 Citations (Scopus)

Elevated JNK activation contributes to the pathogenesis of human brain tumors

Antonyak, M. A., Kenyon, L. C., Godwin, A. K., James, D. C., Emlet, D. R., Okamoto, I., Tnani, M., Holgado-Madruga, M., Moscatello, D. K. & Wong, A. J., Aug 1 2002, In : Oncogene. 21, 33, p. 5038-5046 9 p.

Research output: Contribution to journalArticle

Brain Neoplasms
Tumor Cell Line
MAP Kinase Signaling System
Epidermal Growth Factor Receptor
Epidermal Growth Factor
58 Citations (Scopus)

Enhanced anticancer effect of the combination of BIBW2992 and thymidylate synthase-targeted agents in non-small cell lung cancer with the T790M mutation of epidermal growth factor receptor

Takezawa, K., Okamoto, I., Tanizaki, J., Kuwata, K., Yamaguchi, H., Fukuoka, M., Nishio, K. & Nakagawa, K., Jun 1 2010, In : Molecular Cancer Therapeutics. 9, 6, p. 1647-1656 10 p.

Research output: Contribution to journalArticle

Thymidylate Synthase
Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
Pemetrexed
Mutation
81 Citations (Scopus)

Enhancement of the antitumor activity of ionising radiation by nimotuzumab, a humanised monoclonal antibody to the epidermal growth factor receptor, in non-small cell lung cancer cell lines of differing epidermal growth factor receptor status

Akashi, Y., Okamoto, I., Iwasa, T., Yoshida, T., Suzuki, M., Hatashita, E., Yamada, Y., Satoh, T., Fukuoka, M., Ono, K. & Nakagawa, K., Feb 26 2008, In : British journal of cancer. 98, 4, p. 749-755 7 p.

Research output: Contribution to journalArticle

Antibodies, Monoclonal, Humanized
Ionizing Radiation
Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
Cell Line
59 Citations (Scopus)

Epidermal growth factor receptor in relation to tumor development: EGFR-targeted anticancer therapy

Okamoto, I., Jan 1 2010, In : FEBS Journal. 277, 2, p. 309-315 7 p.

Research output: Contribution to journalShort survey

Epidermal Growth Factor Receptor
Tumors
Neoplasms
Protein-Tyrosine Kinases
Therapeutics
367 Citations (Scopus)

Erlotinib alone or with bevacizumab as first-line therapy in patients with advanced non-squamous non-small-cell lung cancer harbouring EGFR mutations (JO25567): An open-label, randomised, multicentre, phase 2 study

Seto, T., Kato, T., Nishio, M., Goto, K., Atagi, S., Hosomi, Y., Yamamoto, N., Hida, T., Maemondo, M., Nakagawa, K., Nagase, S., Okamoto, I., Yamanaka, T., Tajima, K., Harada, R., Fukuoka, M. & Yamamoto, N., Oct 1 2014, In : The Lancet Oncology. 15, 11, p. 1236-1244 9 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Mutation
Therapeutics
Disease-Free Survival
Bevacizumab

Erlotinib in non-small cell lung cancer

Takeda, M. & Okamoto, I., Jan 1 2011, In : Japanese Journal of Cancer and Chemotherapy. 38, 6, p. 896-900 5 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Protein-Tyrosine Kinases
Quinazolines
Mutation
Disease-Free Survival
6 Citations (Scopus)

Erlotinib Plus Bevacizumab Phase ll Study in Patients with Advanced Non-small-Cell Lung Cancer (JO25567): Updated Safety Results

Kato, T., Seto, T., Nishio, M., Goto, K., Yamamoto, N., Okamoto, I., Tao, L., Yu, W., Khaznadar, T., Tajima, K., Shibata, M., Seki, A. & Yamamoto, N., Feb 1 2018, In : Drug Safety. 41, 2, p. 229-237 9 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Cells
Safety
Epidermal Growth Factor Receptor
Mutation
1 Citation (Scopus)

Erratum: Pemetrexed and carboplatin followed by pemetrexed maintenance therapy in chemo-naïve patients with advanced nonsquamous non-small-cell lung cancer (Investigational New Drugs (DOI 10.1007/s10637-013-9941-z))

Okamoto, I., Aoe, K., Kato, T., Hosomi, Y., Yokoyama, A., Imamura, F., Kiura, K., Hirashima, T., Nishio, M., Nogami, N., Okamoto, H., Saka, H., Yamamoto, N., Yoshizuka, N., Sekiguchi, R., Kiyosawa, K., Nakagawa, K. & Tamura, T., Oct 1 2013, In : Investigational New Drugs. 31, 5, p. 1395-1396 2 p.

Research output: Contribution to journalComment/debate

Pemetrexed
Investigational Drugs
Carboplatin
Non-Small Cell Lung Carcinoma
Therapeutics
7 Citations (Scopus)

Exploration of resistance mechanisms for epidermal growth factor receptor-tyrosine kinase inhibitors based on plasma analysis by digital polymerase chain reaction and next-generation sequencing

Iwama, E., Sakai, K., Azuma, K., Harada, D., Nosaki, K., Hotta, K., Nishio, M., Kurata, T., Fukuhara, T., Akamatsu, H., Goto, K., Shimose, T., Kishimoto, J., Nakanishi, Y., Nishio, K. & Okamoto, I., Dec 1 2018, In : Cancer Science. 109, 12, p. 3921-3933 13 p.

Research output: Contribution to journalArticle

Epidermal Growth Factor Receptor
Protein-Tyrosine Kinases
Polymerase Chain Reaction
Mutation
Neoplasms
2 Citations (Scopus)

Expression of brain-derived neurotrophic factor and its receptor TrkB is associated with poor prognosis and a malignant phenotype in small cell lung cancer

Kimura, S., Harada, T., Ijichi, K., Tanaka, K., Liu, R., Shibahara, D., Kawano, Y., Otsubo, K., Yoneshima, Y., Iwama, E., Nakanishi, Y. & Okamoto, I., Jun 1 2018, In : Lung Cancer. 120, p. 98-107 10 p.

Research output: Contribution to journalArticle

trkB Receptor
Brain-Derived Neurotrophic Factor
Small Cell Lung Carcinoma
Phenotype
Non-Small Cell Lung Carcinoma
15 Citations (Scopus)

Expression of CD44 splicing isoforms in lung cancers: Dominant expression of CD44v8-10 in non-small cell lung carcinomas

Sasaki, J. I. I., Tanabe, K. K., Takahashi, K., Okamoto, I., Fujimoto, H., Matsumoto, M., Suga, M., Ando, M. & Saya, H., Mar 1 1998, In : International journal of oncology. 12, 3, p. 525-533 9 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Lung Neoplasms
Protein Isoforms
Lung
Small Cell Lung Carcinoma
110 Citations (Scopus)

Expression of constitutively activated EGFRvIII in non-small cell lung cancer

Okamoto, I., Kenyon, L. C., Emlet, D. R., Mori, T., Sasaki, J. I., Hirosako, S., Ichikawa, Y., Kishi, H., Godwin, A. K., Yoshioka, M., Suga, M., Matsumoto, M. & Wong, A. J., Jan 1 2003, In : Cancer Science. 94, 1, p. 50-56 7 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Epidermal Growth Factor Receptor
Lung
Neoplasms
epidermal growth factor receptor VIII
7 Citations (Scopus)

Feasibility study of two schedules of sunitinib in combination with pemetrexed in patients with advanced solid tumors

Okamoto, I., Shimizu, T., Miyazaki, M., Tsurutani, J., Ichikawa, Y., Terashima, M., Takeda, M., Fumita, S., Ohki, E., Kimura, N., Hashimoto, J. & Nakagawa, K., Apr 1 2012, In : Investigational New Drugs. 30, 2, p. 639-646 8 p.

Research output: Contribution to journalArticle

Pemetrexed
Feasibility Studies
Appointments and Schedules
Neoplasms
Platelet-Derived Growth Factor Receptors
13 Citations (Scopus)

FGFR gene alterations in lung squamous cell carcinoma are potential targets for the multikinase inhibitor nintedanib

Hibi, M., Kaneda, H., Tanizaki, J., Sakai, K., Togashi, Y., Terashima, M., De Velasco, M. A., Fujita, Y., Banno, E., Nakamura, Y., Takeda, M., Ito, A., Mitsudomi, T., Nakagawa, K., Okamoto, I. & Nishio, K., Nov 1 2016, In : Cancer Science. 107, 11, p. 1667-1676 10 p.

Research output: Contribution to journalArticle

Fibroblast Growth Factor Receptors
Squamous Cell Carcinoma
Lung
Genes
Cell Line
1 Citation (Scopus)

First-line afatinib for the treatment of EGFR mutation-positive non-small-cell lung cancer in the ‘real-world’ clinical setting

Park, K., Wan-Teck Lim, D., Okamoto, I. & Yang, J. C. H., Apr 1 2019, In : Therapeutic Advances in Medical Oncology. 11

Research output: Contribution to journalReview article

Open Access
Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
Mutation
Lung
Therapeutics
117 Citations (Scopus)

FOXQ1 is overexpressed in colorectal cancer and enhances tumorigenicity and tumor growth

Kaneda, H., Arao, T., Tanaka, K., Tamura, D., Aomatsu, K., Kudo, K., Sakai, K., De Velasco, M. A., Matsumoto, K., Fujita, Y., Yamada, Y., Tsurutani, J., Okamoto, I., Nakagawa, K. & Nishio, K., Mar 1 2010, In : Cancer Research. 70, 5, p. 2053-2063 11 p.

Research output: Contribution to journalArticle

Colorectal Neoplasms
Growth
Neoplasms
Microarray Analysis
Gastric Mucins