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Research Output 1998 2019

Article
32 Citations (Scopus)

Combined effect of ALK and MEK inhibitors in EML4-ALK-positive non-small-cell lung cancer cells

Tanizaki, J., Okamoto, I., Takezawa, K., Sakai, K., Azuma, K., Kuwata, K., Yamaguchi, H., Hatashita, E., Nishio, K., Janne, P. A. & Nakagawa, K., Feb 14 2012, In : British journal of cancer. 106, 4, p. 763-767 5 p.

Research output: Contribution to journalArticle

Mitogen-Activated Protein Kinase Kinases
Non-Small Cell Lung Carcinoma
MAP Kinase Signaling System
Apoptosis
Phosphorylation
168 Citations (Scopus)

Combined survival analysis of prospective clinical trials of gefitinib for non-small cell lung cancer with EGFR mutations

Morita, S., Okamoto, I., Kobayashi, K., Yamazaki, K., Asahina, H., Inoue, A., Hagiwara, K., Sunaga, N., Yanagitani, N., Hida, T., Yoshida, K., Hirashima, T., Yasumoto, K., Sugio, K., Mitsudomi, T., Fukuoka, M. & Nukiwa, T., Jul 1 2009, In : Clinical Cancer Research. 15, 13, p. 4493-4498 6 p.

Research output: Contribution to journalArticle

Survival Analysis
Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
Clinical Trials
Mutation
86 Citations (Scopus)

Constitutively active forms of c-Jun NH2-terminal kinase are expressed in primary glial tumors

Tsuiki, H., Tnani, M., Okamoto, I., Kenyon, L. C., Emlet, D. R., Holgado-Madruga, M., Lanham, I. S., Joynes, C. J., Vo, K. T. & Wong, A. J., Jan 1 2003, In : Cancer Research. 63, 1, p. 250-255 6 p.

Research output: Contribution to journalArticle

JNK Mitogen-Activated Protein Kinases
Neuroglia
Protein Isoforms
Neoplasms
Phosphotransferases
53 Citations (Scopus)

CRIPTO1 expression in EGFR-mutant NSCLC elicits intrinsic EGFR-inhibitor resistance

Park, K. S., Raffeld, M., Moon, Y. W., Xi, L., Bianco, C., Pham, T., Lee, L. C., Mitsudomi, T., Yatabe, Y., Okamoto, I., Subramaniam, D., Mok, T., Rosell, R., Luo, J., Salomon, D. S., Wang, Y. & Giaccone, G., Jul 1 2014, In : Journal of Clinical Investigation. 124, 7, p. 3003-3015 13 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
MicroRNAs
Epithelial-Mesenchymal Transition
Protein-Tyrosine Kinases
Mutation
18 Citations (Scopus)

Cystic brain metastasis in non-small-cell lung cancer with ALK rearrangement

Hayashi, H., Okamoto, I., Tanizaki, J., Tanaka, K., Okuda, T., Kato, A., Nishimura, Y. & Nakagawa, K., Jan 1 2014, In : Journal of Clinical Oncology. 32, 36, p. e122-e124 A31.

Research output: Contribution to journalArticle

Gene Rearrangement
Receptor Protein-Tyrosine Kinases
Non-Small Cell Lung Carcinoma
Brain Neoplasms
Cysts
56 Citations (Scopus)

De novo resistance to epidermal growth factor receptor-tyrosine kinase inhibitors in EGFR mutation-positive patients with non-small cell lung cancer

Takeda, M., Okamoto, I., Fujita, Y., Arao, T., Ito, H., Fukuoka, M., Nishio, K. & Nakagawa, K., Jan 1 2010, In : Journal of Thoracic Oncology. 5, 3, p. 399-400 2 p.

Research output: Contribution to journalArticle

Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
Protein-Tyrosine Kinases
Mutation
erbB-1 Genes
86 Citations (Scopus)

Deregulation and Mislocalization of the Cytokinesis Regulator ECT2 Activate the Rho Signaling Pathways Leading to Malignant Transformation

Saito, S., Liu, X. F., Kamijo, K., Raziuddin, R., Tatsumoto, T., Okamoto, I., Chen, X., Lee, C. C., Lorenzi, M. V., Ohara, N. & Miki, T., Feb 20 2004, In : Journal of Biological Chemistry. 279, 8, p. 7169-7179 11 p.

Research output: Contribution to journalArticle

rho GTP-Binding Proteins
Cytokinesis
Deregulation
Nuclear Localization Signals
Guanine Nucleotide Exchange Factors
2 Citations (Scopus)

Detection of identical T cell clones in peritumoral pleural effusion and pneumonitis lesions in a cancer patient during immune-checkpoint blockade

Tanaka, K., Yanagihara, T., Ikematsu, Y., Inoue, H., Ota, K., Kashiwagi, E., Suzuki, K., Hamada, N., Takeuchi, A., Tatsugami, K., Eto, M., Ijichi, K., Oda, Y., Otsubo, K., Yoneshima, Y., Iwama, E., Nakanishi, Y. & Okamoto, I., Jul 17 2018, In : Oncotarget. 9, 55, p. 30587-30593 7 p.

Research output: Contribution to journalArticle

Bronchoalveolar Lavage Fluid
Pleural Effusion
Pneumonia
Clone Cells
T-Cell Antigen Receptor
117 Citations (Scopus)

Differential constitutive activation of the epidermal growth factor receptor in non-small cell lung cancer cells bearing EGFR gene mutation and amplification

Okabe, T., Okamoto, I., Tamura, K., Terashima, M., Yoshida, T., Satoh, T., Takada, M., Fukuoka, M. & Nakagawa, K., Mar 1 2007, In : Cancer Research. 67, 5, p. 2046-2053 8 p.

Research output: Contribution to journalArticle

erbB-1 Genes
Gene Amplification
Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
Mutation
26 Citations (Scopus)

Differential roles of STAT3 depending on the mechanism of STAT3 activation in gastric cancer cells

Okamoto, W., Okamoto, I., Arao, T., Yanagihara, K., Nishio, K. & Nakagawa, K., Jul 26 2011, In : British journal of cancer. 105, 3, p. 407-412 6 p.

Research output: Contribution to journalArticle

STAT3 Transcription Factor
Transcriptional Activation
Stomach Neoplasms
Cell Movement
Protein-Tyrosine Kinases
67 Citations (Scopus)

Differential roles of trans-phosphorylated EGFR, HER2, HER3, and RET as heterodimerisation partners of MET in lung cancer with MET amplification

Tanizaki, J., Okamoto, I., Sakai, K. & Nakagawa, K., Sep 6 2011, In : British journal of cancer. 105, 6, p. 807-813 7 p.

Research output: Contribution to journalArticle

Epidermal Growth Factor Receptor
Lung Neoplasms
Receptor Protein-Tyrosine Kinases
Immunoprecipitation
Cell Migration Assays
57 Citations (Scopus)

Diffuse alveolar damage after ZD1839 therapy in a patient with non-small cell lung cancer

Okamoto, I., Fujii, K., Matsumoto, M., Terasaki, Y., Kihara, N., Kohrogi, H. & Suga, M., Jun 1 2003, In : Lung Cancer. 40, 3, p. 339-342 4 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Therapeutics
Lung
X Ray Computed Tomography
Epidermal Growth Factor Receptor
46 Citations (Scopus)

Digital PCR analysis of plasma cell-free DNA for non-invasive detection of drug resistance mechanisms in EGFR mutant NSCLC: Correlation with paired tumor samples

Ishii, H., Azuma, K., Sakai, K., Kawahara, A., Yamada, K., Tokito, T., Okamoto, I., Nishio, K. & Hoshino, T., Jan 1 2015, In : Oncotarget. 6, 31, p. 30850-30858 9 p.

Research output: Contribution to journalArticle

Plasma Cells
Epidermal Growth Factor Receptor
Drug Resistance
Non-Small Cell Lung Carcinoma
Polymerase Chain Reaction
14 Citations (Scopus)

Discrepancy in programmed cell death-ligand 1 between primary and metastatic non-small cell lung cancer

Takamori, S., Toyokawa, G., Okamoto, I., Takada, K., Kozuma, Y., Matsubara, T., Haratake, N., Akamine, T., Katsura, M., Mukae, N., Shoji, F., Okamoto, T., Oda, Y., Iwaki, T., Iihara, K., Nakanishi, Y. & Maehara, Y., Aug 1 2017, In : Anticancer research. 37, 8, p. 4223-4228 6 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Cell Death
Ligands
Radiotherapy
Brain
3 Citations (Scopus)

Disturbance of the growth hormone-insulin-like growth factor-1 axis associated with poor performance status in patients with solid tumors

Okamoto, I., Munakata, M., Miyazaki, M., Satoh, T., Takahata, T., Takamatsu, Y., Muto, O., Koike, K., Ishitani, K., Mukaiyama, T., Sakata, Y., Nakagawa, K. & Tamura, K., Nov 25 2009, In : Japanese journal of clinical oncology. 40, 3, p. 222-226 5 p., hyp155.

Research output: Contribution to journalArticle

Somatomedins
Growth Hormone
Neoplasms
Hormones
Insulin-Like Growth Factor Binding Protein 3
11 Citations (Scopus)

Dose-escalation study of pemetrexed in combination with carboplatin followed by pemetrexed maintenance therapy for advanced non-small cell lung cancer

Okamoto, I., Takeda, K., Daga, H., Miyazaki, M., Yonesaka, K., Kiyota, H., Tsurutani, J., Ueda, S., Ichikawa, Y., Takeda, M., Sekiguchi, R., Tominaga, K., Enatsu, S., Nambu, Y. & Nakagawa, K., Nov 1 2010, In : Lung Cancer. 70, 2, p. 168-173 6 p.

Research output: Contribution to journalArticle

Pemetrexed
Carboplatin
Non-Small Cell Lung Carcinoma
Therapeutics
Confidence Intervals
17 Citations (Scopus)

Down-regulation of survivin by ultraviolet C radiation is dependent on p53 and results in G2-M arrest in A549 cells

Ikeda, M., Okamoto, I., Tamura, K., Satoh, T., Yonesaka, K., Fukuoka, M. & Nakagawa, K., Apr 18 2007, In : Cancer Letters. 248, 2, p. 292-298 7 p.

Research output: Contribution to journalArticle

Down-Regulation
Radiation
DNA Damage
RNA Interference
Lung Neoplasms
2 Citations (Scopus)

Durable response to nivolumab in a lung adenocarcinoma patient with idiopathic pulmonary fibrosis

Ide, M., Tanaka, K., Sunami, S., Asoh, T., Maeyama, T., Tsuruta, N., Nakanishi, Y. & Okamoto, I., Nov 1 2018, In : Thoracic Cancer. 9, 11, p. 1519-1521 3 p.

Research output: Contribution to journalArticle

Idiopathic Pulmonary Fibrosis
Non-Small Cell Lung Carcinoma
Pleurisy
Respiratory Function Tests
Neoplasms
71 Citations (Scopus)

Effect of dose adjustment on the safety and efficacy of afatinib for EGFR mutation-positive lung adenocarcinoma: Post hoc analyses of the randomized LUX-Lung 3 and 6 trials

Yang, J. C. H., Sequist, L. V., Zhou, C., Schuler, M., Geater, S. L., Mok, T., Hu, C. P., Yamamoto, N., Feng, J., O'Byrne, K., Lu, S., Hirsh, V., Huang, Y., Sebastian, M., Okamoto, I., Dickgreber, N., Shah, R., Märten, A., Massey, D., Wind, S. & 1 others, Wu, Y. L., Jan 1 2016, In : Annals of Oncology. 27, 11, p. 2103-2110 8 p.

Research output: Contribution to journalArticle

Safety
Lung
Mutation
Disease-Free Survival
Non-Small Cell Lung Carcinoma
49 Citations (Scopus)

Effects of Src inhibitors on cell growth and epidermal growth factor receptor and MET signaling in gefitinib-resistant non-small cell lung cancer cells with acquired MET amplification

Yoshida, T., Okamoto, I., Okamoto, W., Hatashita, E., Yamada, Y., Kuwata, K., Nishio, K., Fukuoka, M., Jänne, P. A. & Nakagawa, K., Jan 1 2010, In : Cancer Science. 101, 1, p. 167-172 6 p.

Research output: Contribution to journalArticle

Growth Inhibitors
Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
gefitinib
Mutation
39 Citations (Scopus)

Efficacy and safety analysis according to histology for s-1 in combination with carboplatin as first-line chemotherapy in patients with advanced non-small-cell lung cancer: Updated results of the west japan oncology group lets study

Yoshioka, H., Okamoto, I., Morita, S., Ando, M., Takeda, K., Seto, T., Yamamoto, N., Saka, H., Atagi, S., Hirashima, T., Kudoh, S., Satouchi, M., Ikeda, N., Iwamoto, Y., Sawa, T., Nakanishi, Y. & Nakagawa, K., May 1 2013, In : Annals of Oncology. 24, 5, p. 1326-1331 6 p., mds629.

Research output: Contribution to journalArticle

Carboplatin
Non-Small Cell Lung Carcinoma
Histology
Japan
Safety
26 Citations (Scopus)

Efficacy and safety of weekly nab-paclitaxel plus carboplatin in patients with advanced non-small cell lung cancer

Satouchi, M., Okamoto, I., Sakai, H., Yamamoto, N., Ichinose, Y., Ohmatsu, H., Nogami, N., Takeda, K., Mitsudomi, T., Kasahara, K. & Negoro, S., Jul 1 2013, In : Lung Cancer. 81, 1, p. 97-101 5 p.

Research output: Contribution to journalArticle

Carboplatin
Non-Small Cell Lung Carcinoma
Safety
Paclitaxel
Thrombocytopenia
37 Citations (Scopus)

Efficacy of the tyrosine kinase inhibitor gefitinib in a patient with metastatic small cell lung cancer

Araki, J., Okamoto, I., Suto, R., Ichikawa, Y. & Sasaki, J. I., Jan 1 2005, In : Lung Cancer. 48, 1, p. 141-144 4 p.

Research output: Contribution to journalArticle

Small Cell Lung Carcinoma
Protein-Tyrosine Kinases
Therapeutics
gefitinib
Epidermal Growth Factor Receptor
86 Citations (Scopus)

Elevated JNK activation contributes to the pathogenesis of human brain tumors

Antonyak, M. A., Kenyon, L. C., Godwin, A. K., James, D. C., Emlet, D. R., Okamoto, I., Tnani, M., Holgado-Madruga, M., Moscatello, D. K. & Wong, A. J., Aug 1 2002, In : Oncogene. 21, 33, p. 5038-5046 9 p.

Research output: Contribution to journalArticle

Brain Neoplasms
Tumor Cell Line
MAP Kinase Signaling System
Epidermal Growth Factor Receptor
Epidermal Growth Factor
58 Citations (Scopus)

Enhanced anticancer effect of the combination of BIBW2992 and thymidylate synthase-targeted agents in non-small cell lung cancer with the T790M mutation of epidermal growth factor receptor

Takezawa, K., Okamoto, I., Tanizaki, J., Kuwata, K., Yamaguchi, H., Fukuoka, M., Nishio, K. & Nakagawa, K., Jun 1 2010, In : Molecular Cancer Therapeutics. 9, 6, p. 1647-1656 10 p.

Research output: Contribution to journalArticle

Thymidylate Synthase
Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
Pemetrexed
Mutation
81 Citations (Scopus)

Enhancement of the antitumor activity of ionising radiation by nimotuzumab, a humanised monoclonal antibody to the epidermal growth factor receptor, in non-small cell lung cancer cell lines of differing epidermal growth factor receptor status

Akashi, Y., Okamoto, I., Iwasa, T., Yoshida, T., Suzuki, M., Hatashita, E., Yamada, Y., Satoh, T., Fukuoka, M., Ono, K. & Nakagawa, K., Feb 26 2008, In : British journal of cancer. 98, 4, p. 749-755 7 p.

Research output: Contribution to journalArticle

Antibodies, Monoclonal, Humanized
Ionizing Radiation
Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
Cell Line
367 Citations (Scopus)

Erlotinib alone or with bevacizumab as first-line therapy in patients with advanced non-squamous non-small-cell lung cancer harbouring EGFR mutations (JO25567): An open-label, randomised, multicentre, phase 2 study

Seto, T., Kato, T., Nishio, M., Goto, K., Atagi, S., Hosomi, Y., Yamamoto, N., Hida, T., Maemondo, M., Nakagawa, K., Nagase, S., Okamoto, I., Yamanaka, T., Tajima, K., Harada, R., Fukuoka, M. & Yamamoto, N., Oct 1 2014, In : The Lancet Oncology. 15, 11, p. 1236-1244 9 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Mutation
Therapeutics
Disease-Free Survival
Bevacizumab

Erlotinib in non-small cell lung cancer

Takeda, M. & Okamoto, I., Jan 1 2011, In : Japanese Journal of Cancer and Chemotherapy. 38, 6, p. 896-900 5 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Protein-Tyrosine Kinases
Quinazolines
Mutation
Disease-Free Survival
6 Citations (Scopus)

Erlotinib Plus Bevacizumab Phase ll Study in Patients with Advanced Non-small-Cell Lung Cancer (JO25567): Updated Safety Results

Kato, T., Seto, T., Nishio, M., Goto, K., Yamamoto, N., Okamoto, I., Tao, L., Yu, W., Khaznadar, T., Tajima, K., Shibata, M., Seki, A. & Yamamoto, N., Feb 1 2018, In : Drug Safety. 41, 2, p. 229-237 9 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Cells
Safety
Epidermal Growth Factor Receptor
Mutation
7 Citations (Scopus)

Exploration of resistance mechanisms for epidermal growth factor receptor-tyrosine kinase inhibitors based on plasma analysis by digital polymerase chain reaction and next-generation sequencing

Iwama, E., Sakai, K., Azuma, K., Harada, D., Nosaki, K., Hotta, K., Nishio, M., Kurata, T., Fukuhara, T., Akamatsu, H., Goto, K., Shimose, T., Kishimoto, J., Nakanishi, Y., Nishio, K. & Okamoto, I., Dec 1 2018, In : Cancer Science. 109, 12, p. 3921-3933 13 p.

Research output: Contribution to journalArticle

Epidermal Growth Factor Receptor
Protein-Tyrosine Kinases
Polymerase Chain Reaction
Mutation
Neoplasms
2 Citations (Scopus)

Expression of brain-derived neurotrophic factor and its receptor TrkB is associated with poor prognosis and a malignant phenotype in small cell lung cancer

Kimura, S., Harada, T., Ijichi, K., Tanaka, K., Liu, R., Shibahara, D., Kawano, Y., Otsubo, K., Yoneshima, Y., Iwama, E., Nakanishi, Y. & Okamoto, I., Jun 1 2018, In : Lung Cancer. 120, p. 98-107 10 p.

Research output: Contribution to journalArticle

trkB Receptor
Brain-Derived Neurotrophic Factor
Small Cell Lung Carcinoma
Phenotype
Non-Small Cell Lung Carcinoma
15 Citations (Scopus)

Expression of CD44 splicing isoforms in lung cancers: Dominant expression of CD44v8-10 in non-small cell lung carcinomas

Sasaki, J. I. I., Tanabe, K. K., Takahashi, K., Okamoto, I., Fujimoto, H., Matsumoto, M., Suga, M., Ando, M. & Saya, H., Mar 1 1998, In : International journal of oncology. 12, 3, p. 525-533 9 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Lung Neoplasms
Protein Isoforms
Lung
Small Cell Lung Carcinoma
110 Citations (Scopus)

Expression of constitutively activated EGFRvIII in non-small cell lung cancer

Okamoto, I., Kenyon, L. C., Emlet, D. R., Mori, T., Sasaki, J. I., Hirosako, S., Ichikawa, Y., Kishi, H., Godwin, A. K., Yoshioka, M., Suga, M., Matsumoto, M. & Wong, A. J., Jan 1 2003, In : Cancer Science. 94, 1, p. 50-56 7 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Epidermal Growth Factor Receptor
Lung
Neoplasms
epidermal growth factor receptor VIII
7 Citations (Scopus)

Feasibility study of two schedules of sunitinib in combination with pemetrexed in patients with advanced solid tumors

Okamoto, I., Shimizu, T., Miyazaki, M., Tsurutani, J., Ichikawa, Y., Terashima, M., Takeda, M., Fumita, S., Ohki, E., Kimura, N., Hashimoto, J. & Nakagawa, K., Apr 1 2012, In : Investigational New Drugs. 30, 2, p. 639-646 8 p.

Research output: Contribution to journalArticle

Pemetrexed
Feasibility Studies
Appointments and Schedules
Neoplasms
Platelet-Derived Growth Factor Receptors
13 Citations (Scopus)

FGFR gene alterations in lung squamous cell carcinoma are potential targets for the multikinase inhibitor nintedanib

Hibi, M., Kaneda, H., Tanizaki, J., Sakai, K., Togashi, Y., Terashima, M., De Velasco, M. A., Fujita, Y., Banno, E., Nakamura, Y., Takeda, M., Ito, A., Mitsudomi, T., Nakagawa, K., Okamoto, I. & Nishio, K., Nov 1 2016, In : Cancer Science. 107, 11, p. 1667-1676 10 p.

Research output: Contribution to journalArticle

Fibroblast Growth Factor Receptors
Squamous Cell Carcinoma
Lung
Genes
Cell Line
117 Citations (Scopus)

FOXQ1 is overexpressed in colorectal cancer and enhances tumorigenicity and tumor growth

Kaneda, H., Arao, T., Tanaka, K., Tamura, D., Aomatsu, K., Kudo, K., Sakai, K., De Velasco, M. A., Matsumoto, K., Fujita, Y., Yamada, Y., Tsurutani, J., Okamoto, I., Nakagawa, K. & Nishio, K., Mar 1 2010, In : Cancer Research. 70, 5, p. 2053-2063 11 p.

Research output: Contribution to journalArticle

Colorectal Neoplasms
Growth
Neoplasms
Microarray Analysis
Gastric Mucins
2820 Citations (Scopus)

Gefitinib versus cisplatin plus docetaxel in patients with non-small-cell lung cancer harbouring mutations of the epidermal growth factor receptor (WJTOG3405): an open label, randomised phase 3 trial

Mitsudomi, T., Morita, S., Yatabe, Y., Negoro, S., Okamoto, I., Tsurutani, J., Seto, T., Satouchi, M., Tada, H., Hirashima, T., Asami, K., Katakami, N., Takada, M., Yoshioka, H., Shibata, K., Kudoh, S., Shimizu, E., Saito, H., Toyooka, S., Nakagawa, K. & 1 others, Fukuoka, M., Feb 1 2010, In : The Lancet Oncology. 11, 2, p. 121-128 8 p.

Research output: Contribution to journalArticle

docetaxel
Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
Cisplatin
Mutation

General evidence for the efficacy of maintenance therapy

Tanaka, K. & Okamoto, I., 2012, In : Japanese Journal of Chest Diseases. 71, 10, p. 964-971 8 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Maintenance
Therapeutics
Survival

Genetic Profiling of Non-Small Cell Lung Cancer at Development of Resistance to First- or Second-Generation EGFR-TKIs by CAPP-Seq Analysis of Circulating Tumor DNA

Otsubo, K., Sakai, K., Takeshita, M., Harada, D., Azuma, K., ota, K., Akamatsu, H., Goto, K., Horiike, A., Kurata, T., Nakagaki, N., Nosaki, K., Iwama, E., Nakanishi, Y., Nishio, K. & Okamoto, I., Jan 1 2019, In : Oncologist. 24, 8, p. 1022-1026 5 p.

Research output: Contribution to journalArticle

High-Throughput Nucleotide Sequencing
Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
Protein-Tyrosine Kinases
DNA
22 Citations (Scopus)

HER2 genomic amplification in circulating tumor DNA from patients with cetuximab-resistant colorectal cancer

Takegawa, N., Yonesaka, K., Sakai, K., Ueda, H., Watanabe, S., Nonagase, Y., Okuno, T., Takeda, M., Maenishi, O., Tsurutani, J., Satoh, T., Okamoto, I., Nishio, K., Tamura, T. & Nakagawa, K., Jan 1 2016, In : Oncotarget. 7, 3, p. 3453-3460 8 p.

Research output: Contribution to journalArticle

Colorectal Neoplasms
Epidermal Growth Factor Receptor
DNA
Neoplasms
Antibodies
21 Citations (Scopus)

Heterogeneity of anaplastic lymphoma kinase gene rearrangement in non-small-cell lung carcinomas: A comparative study between small biopsy and excision samples

Abe, H., Kawahara, A., Azuma, K., Taira, T., Takase, Y., Fukumitsu, C., Murata, K., Yamaguchi, T., Akiba, J., Ishii, H., Okamoto, I., Hoshino, T., Takamori, S. & Kage, M., May 30 2015, In : Journal of Thoracic Oncology. 10, 5, p. 800-805 6 p.

Research output: Contribution to journalArticle

Gene Rearrangement
Non-Small Cell Lung Carcinoma
Fluorescence In Situ Hybridization
Biopsy
Immunohistochemistry
2 Citations (Scopus)

Heterogeneous distribution of alectinib in neuroblastoma xenografts revealed by matrix-assisted laser desorption ionization mass spectrometry imaging: a pilot study

Ryu, S., Hayashi, M., Aikawa, H., Okamoto, I., Fujiwara, Y. & Hamada, A., Jan 1 2018, In : British Journal of Pharmacology. 175, 1, p. 29-37 9 p.

Research output: Contribution to journalArticle

Matrix-Assisted Laser Desorption-Ionization Mass Spectrometry
Neuroblastoma
Heterografts
Lasers
Ions
25 Citations (Scopus)

High-dose dexamethasone plus antihistamine prevents colorectal cancer patients treated with modified FOLFOX6 from hypersensitivity reactions induced by oxaliplatin

Kidera, Y., Satoh, T., Ueda, S., Okamoto, W., Okamoto, I., Fumita, S., Yonesaka, K., Hayashi, H., Makimura, C., Okamoto, K., Kiyota, H., Tsurutani, J., Miyazaki, M., Yoshinaga, M., Fujiwara, K., Yamazoe, Y., Moriyama, K., Tsubaki, M., Chiba, Y., Nishida, S. & 1 others, Nakagawa, K., Jun 1 2011, In : International Journal of Clinical Oncology. 16, 3, p. 244-249 6 p.

Research output: Contribution to journalArticle

oxaliplatin
Histamine Antagonists
Dexamethasone
Colorectal Neoplasms
Hypersensitivity
18 Citations (Scopus)

Highly sensitive and quantitative evaluation of the EGFR T790M mutation by nanofluidic digital PCR

Iwama, E., Takayama, K., Harada, T., Okamoto, I., Ookubo, F., Kishimoto, J., Baba, E., Oda, Y. & Nakanishi, Y., Jan 1 2015, In : Oncotarget. 6, 24, p. 20466-20473 8 p.

Research output: Contribution to journalArticle

Polymerase Chain Reaction
Mutation
Alleles
Therapeutics
Neoplasms
19 Citations (Scopus)

Highly specific and sensitive detection of malignancy in urine samples from patients with urothelial cancer by CD44v8-10/CD44v10 competitive RT-PCR

Miyake, H., Okamoto, I., Hiara, I., Gohji, K., Yamanaka, K., Arakawa, S., Kamidono, S. & Saya, H., Dec 14 1998, In : International Journal of Cancer. 79, 6, p. 560-564 5 p.

Research output: Contribution to journalArticle

Urine
Polymerase Chain Reaction
Neoplasms
Reverse Transcription
Protein Isoforms
25 Citations (Scopus)

Histology and smoking status predict survival of patients with advanced non-small-cell lung cancer: Results of west Japan oncology group (WJOG) study 3906L

Kogure, Y., Ando, M., Saka, H., Chiba, Y., Yamamoto, N., Asami, K., Hirashima, T., Seto, T., Nagase, S., Otsuka, K., Yanagihara, K., Takeda, K., Okamoto, I., Aoki, T., Takayama, K., Yamasaki, M., Kudoh, S., Katakami, N., Miyazaki, M. & Nakagawa, K., Jan 1 2013, In : Journal of Thoracic Oncology. 8, 6, p. 753-758 6 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Histology
Japan
Smoking
Adenocarcinoma
301 Citations (Scopus)

Human ECT2 is an exchange factor for Rho GTPases, phosphorylated in G2/M phases, and involved in cytokinesis

Tatsumoto, T., Xie, X., Blumenthal, R., Okamoto, I. & Miki, T., Nov 29 1999, In : Journal of Cell Biology. 147, 5, p. 921-927 7 p.

Research output: Contribution to journalArticle

rho GTP-Binding Proteins
Cytokinesis
G2 Phase
Cell Division
Interphase
19 Citations (Scopus)

Human papillomavirus DNA and p16 expression in Japanese patients with oropharyngeal squamous cell carcinoma

Kawakami, H., Okamoto, I., Terao, K., Sakai, K., Suzuki, M., Ueda, S., Tanaka, K., Kuwata, K., Morita, Y., Ono, K., Nishio, K., Nishimura, Y., Doi, K. & Nakagawa, K., Jan 1 2013, In : Cancer Medicine. 2, 6, p. 933-941 9 p.

Research output: Contribution to journalArticle

Squamous Cell Carcinoma
DNA
p16 Genes
Methylation
Cisplatin
9 Citations (Scopus)

Hypermethylation of the CpG dinucleotide in epidermal growth factor receptor codon 790: Implications for a mutational hotspot leading to the T790M mutation in non-small-cell lung cancer

Fujii, A., Harada, T., Iwama, E., ota, K., Furuyama, K., Ijichi, K., Okamoto, T., Okamoto, I., Takayama, K. & Nakanishi, Y., May 1 2015, In : Cancer Genetics. 208, 5, p. 271-278 8 p.

Research output: Contribution to journalArticle

5-Methylcytosine
Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
Codon
Mutation
48 Citations (Scopus)

Identification of c-Src as a potential therapeutic target for gastric cancer and of MET activation as a cause of resistance to c-Src inhibition

Okamoto, W., Okamoto, I., Yoshida, T., Okamoto, K., Takezawa, K., Hatashita, E., Yamada, Y., Kuwata, K., Arao, T., Yanagihara, K., Fukuoka, M., Nishio, K. & Nakagawa, K., May 1 2010, In : Molecular Cancer Therapeutics. 9, 5, p. 1188-1197 10 p.

Research output: Contribution to journalArticle

Stomach Neoplasms
Cell Line
Extracellular Signal-Regulated MAP Kinases
Therapeutics
Apoptosis