Research Output per year
Research Output 1998 2019
- 100 - 150 out of 276 results
- Publication Year, Title (descending)
The pan-HER family tyrosine kinase inhibitor afatinib overcomes HER3 ligand heregulin-mediated resistance to EGFR inhibitors in non-small cell lung cancer
Yonesaka, K., Kudo, K., Nishida, S., Takahama, T., Iwasa, T., Yoshida, T., Tanaka, K., Takeda, M., Kaneda, H., Okamoto, I., Nishio, K. & Nakagawa, K., Jan 1 2015, In : Oncotarget. 6, 32, p. 33602-33611 10 p.Research output: Contribution to journal › Article
Tolerability of nintedanib (BIBF 1120) in combination with docetaxel: A phase 1 study in japanese patients with previously treated non-small-cell lung cancer
Okamoto, I., Miyazaki, M., Takeda, M., Terashima, M., Azuma, K., Hayashi, H., Kaneda, H., Kurata, T., Tsurutani, J., Seto, T., Hirai, F., Konishi, K., Sarashina, A., Yagi, N., Kaiser, R. & Nakagawa, K., Feb 6 2015, In : Journal of Thoracic Oncology. 10, 2, p. 346-352 7 p.Research output: Contribution to journal › Article
Addition of bevacizumab enhances antitumor activity of erlotinib against non-small cell lung cancer xenografts depending on VEGF expression
Li, H., Takayama, K., Wang, S., Shiraishi, Y., Gotanda, K., Harada, T., Furuyama, K., Iwama, E., Ieiri, I., Okamoto, I. & Nakanishi, Y., Oct 9 2014, In : Cancer chemotherapy and pharmacology. 74, 6, p. 1297-1305 9 p.Research output: Contribution to journal › Article
A phase I study of split-dose cisplatin and etoposide with concurrent accelerated hyperfractionated thoracic radiotherapy in elderly patients with limited-disease small cell lung cancer
Okamoto, K., Okamoto, I., Takeda, M., Kobayashi, S., Takeda, K., Nakamatsu, K., Nishimura, Y. & Nakagawa, K., Aug 2014, In : Japanese journal of clinical oncology. 44, 8, p. 743-748 6 p., hyu071.Research output: Contribution to journal › Article
Association of PD-L1 overexpression with activating EGFR mutations in surgically resected nonsmall-cell lung cancer
Azuma, K., Ota, K., Kawahara, A., Hattori, S., Iwama, E., Harada, T., Matsumoto, K., Takayama, K., Takamori, S., Kage, M., Hoshino, T., Nakanishi, Y. & Okamoto, I., Oct 1 2014, In : Annals of oncology : official journal of the European Society for Medical Oncology / ESMO. 25, 10, p. 1935-1940 6 p.Research output: Contribution to journal › Article
Bilateral ovarian metastasis of non-small cell lung cancer with ALK rearrangement
Fujiwara, A., Higashiyama, M., Kanou, T., Tokunaga, T., Okami, J., Kodama, K., Nishino, K., Tomita, Y. & Okamoto, I., Feb 1 2014, In : Lung Cancer. 83, 2, p. 302-304 3 p.Research output: Contribution to journal › Article
CRIPTO1 expression in EGFR-mutant NSCLC elicits intrinsic EGFR-inhibitor resistance
Park, K. S., Raffeld, M., Moon, Y. W., Xi, L., Bianco, C., Pham, T., Lee, L. C., Mitsudomi, T., Yatabe, Y., Okamoto, I., Subramaniam, D., Mok, T., Rosell, R., Luo, J., Salomon, D. S., Wang, Y. & Giaccone, G., Jul 1 2014, In : Journal of Clinical Investigation. 124, 7, p. 3003-3015 13 p.Research output: Contribution to journal › Article
Current status and future perspectives of cooperative study groups for lung cancer in Japan
Kawano, Y., Okamoto, I., Fukuda, H., Ohe, Y., Nakamura, S., Nakagawa, K., Hotta, K., Kiura, K., Takiguchi, Y., Saka, H., Okamoto, H., Takayama, K., Semba, H., Kobayashi, K., Kenmotsu, H., Tsuboi, M., Yamamoto, N., Nukiwa, T. & Nakanishi, Y., Nov 1 2014, In : Respiratory Investigation. 52, 6, p. 339-347 9 p.Research output: Contribution to journal › Review article
Cystic brain metastasis in non-small-cell lung cancer with ALK rearrangement
Hayashi, H., Okamoto, I., Tanizaki, J., Tanaka, K., Okuda, T., Kato, A., Nishimura, Y. & Nakagawa, K., Jan 1 2014, In : Journal of Clinical Oncology. 32, 36, p. e122-e124 A31.Research output: Contribution to journal › Article
Development of anaplastic lymphoma kinase (ALK) inhibitors and molecular diagnosis in ALK rearrangement-positive lung cancer
Iwama, E., Okamoto, I., Harada, T., Takayama, K. & Nakanishi, Y., Mar 5 2014, In : OncoTargets and Therapy. 7, p. 375-385 11 p.Research output: Contribution to journal › Review article
Erlotinib alone or with bevacizumab as first-line therapy in patients with advanced non-squamous non-small-cell lung cancer harbouring EGFR mutations (JO25567): An open-label, randomised, multicentre, phase 2 study
Seto, T., Kato, T., Nishio, M., Goto, K., Atagi, S., Hosomi, Y., Yamamoto, N., Hida, T., Maemondo, M., Nakagawa, K., Nagase, S., Okamoto, I., Yamanaka, T., Tajima, K., Harada, R., Fukuoka, M. & Yamamoto, N., Oct 1 2014, In : The Lancet Oncology. 15, 11, p. 1236-1244 9 p.Research output: Contribution to journal › Article
Multiplex genomic profiling of non-small cell lung cancers from the LETS phase III trial of first-line S-1/carboplatin versus paclitaxel/carboplatin: Results of a West Japan Oncology Group study
Okamoto, I., Sakai, K., Morita, S., Yoshioka, H., Kaneda, H., Takeda, K., Hirashima, T., Kogure, Y., Kimura, T., Takahashi, T., Atagi, S., Seto, T., Sawa, T., Yamamoto, M., Satouchi, M., Okuno, M., Nagase, S., Takayama, K., Tomii, K., Maeda, T. & 8 others, , Apr 2014, In : Oncotarget. 5, 8, p. 2293-2304 12 p.Research output: Contribution to journal › Article
Patient-reported neuropathy and taxane-associated symptoms in a phase 3 trial of nab-paclitaxel plus carboplatin versus solvent-based paclitaxel plus carboplatin for advanced non-small-cell lung cancer
Hirsh, V., Okamoto, I., Hon, J. K., Page, R. D., Orsini, J., Sakai, H., Zhang, H., Renschler, M. F. & Socinski, M. A., Jan 1 2014, In : Journal of Thoracic Oncology. 9, 1, p. 83-90 8 p.Research output: Contribution to journal › Article
Phase II clinical trial of S-1 plus oral leucovorin in previously treated patients with non-small-cell lung cancer
Naito, T., Seto, T., Takeda, K., Goto, K., Okamoto, I., Nakagawa, K., Ohba, T., Murakami, H., Takahashi, T., Yamanaka, T. & Yamamoto, N., Dec 1 2014, In : Lung Cancer. 86, 3, p. 339-343 5 p.Research output: Contribution to journal › Article
Phase II study of zoledronic acid combined with docetaxel for non-small-cell lung cancer: West Japan Oncology Group
Murakami, H., Yamanaka, T., Seto, T., Sugio, K., Okamoto, I., Sawa, T., Hirashima, T., Takeda, K., Atagi, S., Fukuoka, M., Nakanishi, Y., Nakagawa, K. & Yamamoto, N., Aug 2014, In : Cancer Science. 105, 8, p. 989-995 7 p.Research output: Contribution to journal › Article
Survival outcome assessed according to tumor response and shrinkage pattern in patients with EGFR mutation-positive non-small-cell lung cancer treated with gefitinib or erlotinib
Takeda, M., Okamoto, I. & Nakagawa, K., Feb 1 2014, In : Journal of Thoracic Oncology. 9, 2, p. 200-204 5 p.Research output: Contribution to journal › Article
The anti-HER3 antibody patritumab abrogates cetuximab resistance mediated by heregulin in colorectal cancer cells
Kawakami, H., Okamoto, I., Yonesaka, K., Okamoto, K., Shibata, K., Shinkai, Y., Sakamoto, H., Kitano, M., Tamura, T., Nishio, K. & Nakagawa, K., Jan 1 2014, In : Oncotarget. 5, 23, p. 11847-11856 10 p.Research output: Contribution to journal › Article
Tyrosine phosphoproteomics identifies both codrivers and cotargeting strategies for T790M-related EGFR-TKI resistance in non-small cell lung cancer
Yoshida, T., Zhang, G., Smith, M. A., Lopez, A. S., Bai, Y., Li, J., Fang, B., Koomen, J., Rawal, B., Fisher, K. J., Chen, A. Y., Kitano, M., Morita, Y., Yamaguchi, H., Shibata, K., Okabe, T., Okamoto, I., Nakagawa, K. & Haura, E. B., Aug 1 2014, In : Clinical Cancer Research. 20, 15, p. 4059-4074 16 p.Research output: Contribution to journal › Article
A phase I, pharmacokinetic and pharmacodynamic study of nimotuzumab in Japanese patients with advanced solid tumors
Okamoto, W., Yoshino, T., Takahashi, T., Okamoto, I., Ueda, S., Tsuya, A., Boku, N., Nishio, K., Fukuoka, M., Yamamoto, N. & Nakagawa, K., Nov 1 2013, In : Cancer chemotherapy and pharmacology. 72, 5, p. 1063-1071 9 p.Research output: Contribution to journal › Article
A phase II study of cisplatin /S-1 in patients with carcinomas of unknown primary site
Tsuya, A., Kurata, T., Tamiya, A., Okamoto, I., Ueda, S., Sakai, D., Sugimoto, N., Matsumoto, K., Goto, I., Yamamoto, N., Fukuoka, M. & Nakagawa, K., Dec 1 2013, In : Investigational New Drugs. 31, 6, p. 1568-1572 5 p.Research output: Contribution to journal › Article
A phase i study of S-1 with concurrent radiotherapy in elderly patients with locally advanced non-small cell lung cancer
Hasegawa, Y., Okamoto, I., Takezawa, K., Miyazaki, M., Tsurutani, J., Yonesaka, K., Morinaga, R., Tsuya, A., Terashima, M., Kudoh, T., Azuma, K., Kurata, T., Nishikawa, T., Fukuoka, M., Nishimura, Y. & Nakagawa, K., Jun 1 2013, In : Investigational New Drugs. 31, 3, p. 599-604 6 p.Research output: Contribution to journal › Article
Bronchoscopic findings for bevacizumab-related pulmonary hemorrhage in advanced non-small cell lung cancer
Okamoto, K., Okamoto, I., Miyazaki, M., Tanaka, K., Kaneda, H. & Nakagawa, K., Oct 1 2013, In : Investigational New Drugs. 31, 5, p. 1364-1366 3 p.Research output: Contribution to journal › Article
Clinical impact of continued crizotinib administration after isolated central nervous system progression in patients with lung cancer positive for ALK rearrangement
Takeda, M., Okamoto, I. & Nakagawa, K., May 1 2013, In : Journal of Thoracic Oncology. 8, 5, p. 654-657 4 p.Research output: Contribution to journal › Article
Clinical response to crizotinib retreatment after acquisition of drug resistance
Matsuoka, H., Kurata, T., Okamoto, I., Kaneda, H., Tanaka, K. & Nakagawa, K., Jul 1 2013, In : Journal of Clinical Oncology. 31, 19Research output: Contribution to journal › Article
Efficacy and safety analysis according to histology for s-1 in combination with carboplatin as first-line chemotherapy in patients with advanced non-small-cell lung cancer: Updated results of the west japan oncology group lets study
Yoshioka, H., Okamoto, I., Morita, S., Ando, M., Takeda, K., Seto, T., Yamamoto, N., Saka, H., Atagi, S., Hirashima, T., Kudoh, S., Satouchi, M., Ikeda, N., Iwamoto, Y., Sawa, T., Nakanishi, Y. & Nakagawa, K., May 1 2013, In : Annals of Oncology. 24, 5, p. 1326-1331 6 p., mds629.Research output: Contribution to journal › Article
Efficacy and safety of weekly nab-paclitaxel plus carboplatin in patients with advanced non-small cell lung cancer
Satouchi, M., Okamoto, I., Sakai, H., Yamamoto, N., Ichinose, Y., Ohmatsu, H., Nogami, N., Takeda, K., Mitsudomi, T., Kasahara, K. & Negoro, S., Jul 1 2013, In : Lung Cancer. 81, 1, p. 97-101 5 p.Research output: Contribution to journal › Article
Erratum: Pemetrexed and carboplatin followed by pemetrexed maintenance therapy in chemo-naïve patients with advanced nonsquamous non-small-cell lung cancer (Investigational New Drugs (DOI 10.1007/s10637-013-9941-z))
Okamoto, I., Aoe, K., Kato, T., Hosomi, Y., Yokoyama, A., Imamura, F., Kiura, K., Hirashima, T., Nishio, M., Nogami, N., Okamoto, H., Saka, H., Yamamoto, N., Yoshizuka, N., Sekiguchi, R., Kiyosawa, K., Nakagawa, K. & Tamura, T., Oct 1 2013, In : Investigational New Drugs. 31, 5, p. 1395-1396 2 p.Research output: Contribution to journal › Comment/debate
Histology and smoking status predict survival of patients with advanced non-small-cell lung cancer: Results of west Japan oncology group (WJOG) study 3906L
Kogure, Y., Ando, M., Saka, H., Chiba, Y., Yamamoto, N., Asami, K., Hirashima, T., Seto, T., Nagase, S., Otsuka, K., Yanagihara, K., Takeda, K., Okamoto, I., Aoki, T., Takayama, K., Yamasaki, M., Kudoh, S., Katakami, N., Miyazaki, M. & Nakagawa, K., Jun 2013, In : Journal of Thoracic Oncology. 8, 6, p. 753-758 6 p.Research output: Contribution to journal › Article
Human papillomavirus DNA and p16 expression in Japanese patients with oropharyngeal squamous cell carcinoma
Kawakami, H., Okamoto, I., Terao, K., Sakai, K., Suzuki, M., Ueda, S., Tanaka, K., Kuwata, K., Morita, Y., Ono, K., Nishio, K., Nishimura, Y., Doi, K. & Nakagawa, K., Dec 2013, In : Cancer Medicine. 2, 6, p. 933-941 9 p.Research output: Contribution to journal › Article
MET amplification as a potential therapeutic target in gastric cancer
Kawakami, H., Okamoto, I., Arao, T., Okamoto, W., Matsumoto, K., Taniguchi, H., Kuwata, K., Yamaguchi, H., Nishio, K., Nakagawa, K. & Yamada, Y., 2013, In : Oncotarget. 4, 1, p. 9-17 9 p.Research output: Contribution to journal › Article
Molecularly targeted approaches herald a new era of non-small-cell lung cancer treatment
Kaneda, H., Yoshida, T. & Okamoto, I., May 29 2013, In : Cancer Management and Research. 5, 1, p. 91-101 11 p.Research output: Contribution to journal › Review article
Pemetrexed and carboplatin followed by pemetrexed maintenance therapy in chemo-naïve patients with advanced nonsquamous non-small-cell lung cancer
Okamoto, I., Aoe, K., Kato, T., Hosomi, Y., Yokoyama, A., Imamura, F., Kiura, K., Hirashima, T., Nishio, M., Nogami, N., Okamoto, H., Saka, H., Yamamoto, N., Yoshizuka, N., Sekiguchi, R., Kiyosawa, K., Nakagawa, K. & Tamura, T., Jan 1 2013, In : Investigational New Drugs. 31, 5, p. 1275-1282 8 p.Research output: Contribution to journal › Article
Perturbation of the mutated EGFR interactome identifies vulnerabilities and resistance mechanisms
Li, J., Bennett, K., Stukalov, A., Fang, B., Zhang, G., Yoshida, T., Okamoto, I., Kim, J. Y., Song, L., Bai, Y., Qian, X., Rawal, B., Schell, M., Grebien, F., Winter, G., Rix, U., Eschrich, S., Colinge, J., Koomen, J., Superti-Furga, G. & 1 others, , Nov 5 2013, In : Molecular Systems Biology. 9, 705.Research output: Contribution to journal › Article
Phase 2 study of S-1 and carboplatin plus bevacizumab followed by maintenance S-1 and bevacizumab for chemotherapy-naive patients with advanced nonsquamous non-small cell lung cancer
Urata, Y., Okamoto, I., Takeda, M., Hattori, Y., Okuno, K., Shimada, T., Kurata, T., Kaneda, H., Miyazaki, M., Terashima, M., Tanaka, K., Morita, S., Nakagawa, K., Negoro, S. & Satouchi, M., Jun 15 2013, In : Cancer. 119, 12, p. 2275-2281 7 p.Research output: Contribution to journal › Article
Phase i and pharmacokinetic study of gefitinib and S-1 combination therapy for advanced adenocarcinoma of the lung
Kiyota, H., Okamoto, I., Takeda, M., Daga, H., Naito, T., Miyazaki, M., Okada, H., Hayashi, H., Tanaka, K., Terashima, M., Azuma, K., Murakami, H., Takeda, K., Yamamoto, N. & Nakagawa, K., Apr 1 2013, In : Cancer Chemotherapy and Pharmacology. 71, 4, p. 859-865 7 p.Research output: Contribution to journal › Article
Phase II study of bi-weekly irinotecan for patients with previously treated HER2-negative metastatic breast cancer: KMBOG0610B
Hayashi, H., Tsurutani, J., Satoh, T., Masuda, N., Okamoto, W., Morinaga, R., Terashima, M., Miyazaki, M., Okamoto, I., Nishida, Y., Tominaga, S., Tokunaga, Y., Yamaguchi, M., Sakamoto, J., Nakayama, T. & Nakagawa, K., Apr 1 2013, In : Breast Cancer. 20, 2, p. 131-136 6 p.Research output: Contribution to journal › Article
Phase I pharmacokinetic study of S-1 granules and nedaplatin for advanced head and neck cancer
Hayashi, H., Okamoto, I., Ueda, S., Tanaka, K., Okamoto, K., Kawakami, H., Nishina, S., Takeda, M., Fujisaka, Y., Satoh, T., Terao, K., Nishimura, Y., Doi, K. & Nakagawa, K., Dec 1 2013, In : Anticancer research. 33, 12, p. 5699-5706 8 p.Research output: Contribution to journal › Article
Postprogression survival for first-line chemotherapy in patients with advanced gastric cancer
Kawakami, H., Okamoto, I., Hayashi, H., Taguri, M., Morita, S. & Nakagawa, K., Sep 1 2013, In : European Journal of Cancer. 49, 14, p. 3003-3009 7 p.Research output: Contribution to journal › Article
Postprogression survival in patients with advanced non-small-cell lung cancer who receive second-line or third-line chemotherapy
Hayashi, H., Okamoto, I., Taguri, M., Morita, S. & Nakagawa, K., Jul 15 2013, In : Clinical Lung Cancer. 14, 3, p. 261-266 6 p.Research output: Contribution to journal › Article
Randomized, open-label, phase III study comparing irinotecan with paclitaxel in patients with advanced gastric cancer without severe peritoneal metastasis after failure of prior combination chemotherapy using fluoropyrimidine plus platinum: WJOG 4007 trial
Hironaka, S., Ueda, S., Yasui, H., Nishina, T., Tsuda, M., Tsumura, T., Sugimoto, N., Shimodaira, H., Tokunaga, S., Moriwaki, T., Esaki, T., Nagase, M., Fujitani, K., Yamaguchi, K., Ura, T., Hamamoto, Y., Morita, S., Okamoto, I., Boku, N. & Hyodo, I., Dec 10 2013, In : Journal of Clinical Oncology. 31, 35, p. 4438-4444 7 p.Research output: Contribution to journal › Article
Rapid response of brain metastasis to crizotinib in a patient with ALK rearrangement-positive non-small-cell lung cancer
Kaneda, H., Okamoto, I. & Nakagawa, K., Apr 1 2013, In : Journal of Thoracic Oncology. 8, 4, p. e32-e33Research output: Contribution to journal › Article
Safety and efficacy analysis by histology of weekly nab-paclitaxel in combination with carboplatin as first-line therapy in patients with advanced non-small-cell lung cancer
Socinski, M. A., Okamoto, I., Hon, J. K., Hirsh, V., Dakhil, S. R., Page, R. D., Orsini, J., Yamamoto, N., Zhang, H. & Renschler, M. F., Sep 1 2013, In : Annals of Oncology. 24, 9, p. 2390-2396 7 p., mdt235.Research output: Contribution to journal › Article
Safety and efficacy of weekly nab ® -paclitaxel in combination with carboplatin as first-line therapy in elderly patients with advanced non-small-cell lung cancer
Socinski, M. A., Langer, C. J., Okamoto, I., Hon, J. K., Hirsh, V., Dakhil, S. R., Page, R. D., Orsini, J., Zhang, H. & Renschler, M. F., Feb 1 2013, In : Annals of Oncology. 24, 2, p. 314-321 8 p., mds461.Research output: Contribution to journal › Article
Severe acute interstitial lung disease after crizotinib therapy in a patient with EML4-ALK-positive non-small-cell lung cancer
Tamiya, A., Okamoto, I., Miyazaki, M., Shimizu, S., Kitaichi, M. & Nakagawa, K., Jan 1 2013, In : Journal of Clinical Oncology. 31, 1Research output: Contribution to journal › Article
Sorting nexin 2-mediated membrane trafficking of c-Met contributes to sensitivity of molecular-targeted drugs
Ogi, S., Fujita, H., Kashihara, M., Yamamoto, C., Sonoda, K., Okamoto, I., Nakagawa, K., Ohdo, S., Tanaka, Y., Kuwano, M. & Ono, M., May 1 2013, In : Cancer Science. 104, 5, p. 573-583 11 p.Research output: Contribution to journal › Article
[Molecular-targeted drug for non-small cell lung cancer].
Okamoto, I., Jan 1 2012, In : Unknown Journal. 70 Suppl 8, p. 438-442 5 p.Research output: Contribution to journal › Article
Activation of HER family signaling as a mechanism of acquired resistance to ALK inhibitors in EML4-ALK-positive non-small cell lung cancer
Tanizaki, J., Okamoto, I., Okabe, T., Sakai, K., Tanaka, K., Hayashi, H., Kaneda, H., Takezawa, K., Kuwata, K., Yamaguchi, H., Hatashita, E., Nishio, K. & Nakagawa, K., Nov 15 2012, In : Clinical Cancer Research. 18, 22, p. 6219-6226 8 p.Research output: Contribution to journal › Article
A novel mass spectrometry-based assay for diagnosis of EML4-ALK-positive non-small cell lung cancer
Sakai, K., Okamoto, I., Takezawa, K., Hirashima, T., Kaneda, H., Takeda, M., Matsumoto, K., Kimura, H., Fujita, Y., Nakagawa, K., Arao, T. & Nishio, K., Jan 1 2012, In : Journal of Thoracic Oncology. 7, 5, p. 913-918 6 p.Research output: Contribution to journal › Article
Antitumor action of the MET tyrosine kinase inhibitor crizotinib (PF-02341066) in gastric cancer positive for MET amplification
Okamoto, W., Okamoto, I., Arao, T., Kuwata, K., Hatashita, E., Yamaguchi, H., Sakai, K., Yanagihara, K., Nishio, K. & Nakagawa, K., Jul 1 2012, In : Molecular Cancer Therapeutics. 11, 7, p. 1557-1564 8 p.Research output: Contribution to journal › Article
Association of the expression of mutant epidermal growth factor receptor protein as determined with mutation-specific antibodies in non-small cell lung cancer with progression-free survival after gefitinib treatment
Azuma, K., Okamoto, I., Kawahara, A., Taira, T., Nakashima, K., Hattori, S., Kinoshita, T., Takeda, M., Nakagawa, K., Takamori, S., Kuwano, M., Ono, M. & Kage, M., Jan 1 2012, In : Journal of Thoracic Oncology. 7, 1, p. 122-127 6 p.Research output: Contribution to journal › Article