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Isamu Okamoto

Lecturer

  • 13976 Citations
  • 57 h-Index
19982020
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Research Output 1998 2020

2015
4 Citations (Scopus)

Infected complex renal cysts during crizotinib therapy in a patient with non-small cell lung cancer positive for ALK rearrangement

Yoneshima, Y., Okamoto, I., Arimura-Omori, M., Kimura, S., Hidaka-Fujimoto, N., Iwama, E., Harada, T., Takayama, K. & Nakanishi, Y., Apr 1 2015, In : Investigational New Drugs. 33, 2, p. 510-512 3 p.

Research output: Contribution to journal › Article

Non-Small Cell Lung Carcinoma
Cysts
Kidney
Therapeutics
Low Back Pain
2 Citations (Scopus)

Multiple regulatory mechanisms of hepatocyte growth factor expression in malignant cells with a short poly(dA) sequence in the HGF gene promoter

Sakai, K., Takeda, M., Okamoto, I., Nakagawa, K. & Nishio, K., Jan 1 2015, In : Oncology Letters. 9, 1, p. 405-410 6 p.

Research output: Contribution to journal › Article

Hepatocyte Growth Factor
Genes
Single Nucleotide Polymorphism
Cell Line
Introns
20 Citations (Scopus)

Nicotine induces resistance to erlotinib via cross-talk between α 1 nAChR and EGFR in the non-small cell lung cancer xenograft model

Li, H., Wang, S., Takayama, K., Harada, T., Okamoto, I., Iwama, E., Fujii, A., Ota, K., Hidaka, N., Kawano, Y. & Nakanishi, Y., Apr 1 2015, In : Lung Cancer. 88, 1, p. 1-8 8 p.

Research output: Contribution to journal › Article

Nicotinic Receptors
Nicotine
Heterografts
Non-Small Cell Lung Carcinoma
MAP Kinase Signaling System
16 Citations (Scopus)

Phase i study of amatuximab, a novel monoclonal antibody to mesothelin, in Japanese patients with advanced solid tumors

Fujisaka, Y., Kurata, T., Tanaka, K., Kudo, T., Okamoto, K., Tsurutani, J., Kaneda, H., Okamoto, I., Namiki, M., Kitamura, C. & Nakagawa, K., Apr 1 2015, In : Investigational New Drugs. 33, 2, p. 380-388 9 p.

Research output: Contribution to journal › Article

Monoclonal Antibodies
Maximum Tolerated Dose
Mesothelioma
Neoplasms
Adenocarcinoma
4 Citations (Scopus)

Phase i study of nintedanib in combination with pemetrexed as second-line treatment of Japanese patients with advanced non-small cell lung cancer

Daga, H., Takeda, K., Okada, H., Miyazaki, M., Ueda, S., Kaneda, H., Okamoto, I., Yoh, K., Goto, K., Konishi, K., Sarashina, A., Tanaka, T., Kaiser, R. & Nakagawa, K., Dec 1 2015, In : Cancer chemotherapy and pharmacology. 76, 6, p. 1225-1233 9 p.

Research output: Contribution to journal › Article

Pemetrexed
Non-Small Cell Lung Carcinoma
Cells
Maximum Tolerated Dose
Toxicity
81 Citations (Scopus)

Pooled safety analysis of EGFR-TKI treatment for EGFR mutation-positive non-small cell lung cancer

Takeda, M., Okamoto, I. & Nakagawa, K., Apr 1 2015, In : Lung Cancer. 88, 1, p. 74-79 6 p.

Research output: Contribution to journal › Article

Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
Protein-Tyrosine Kinases
Safety
Mutation
16 Citations (Scopus)

Randomized controlled trial comparing docetaxel-cisplatin combination with weekly docetaxel alone in elderly patients with advanced non-small-cell lung cancer: Japan Clinical Oncology Group (JCOG) 0207

Tsukada, H., Yokoyama, A., Goto, K., Shinkai, T., Harada, M., Ando, M., Shibata, T., Ohe, Y., Tamura, T., Saijo, N., Yamamoto, N., Nishiwaki, Y., Kubota, K., Segawa, Y., Isobe, H., Eguchi, H., Yoneda, S., Sakai, H., Sawa, T., Ishiguro, T. & 24 others, Nakagawa, K., Okamoto, I., Kawahara, M., Atagi, S., Nakano, T., Miyake, M., Kaburaki, T., Fujita, Y., Fujiuchi, S., Kudo, K., Takeda, Y., Hida, T., Senba, H., Fujii, S., Tsukamoto, T., Nagasawa, M., Minato, K., Yoshino, R., Watanabe, K., Kunikane, H., Saito, H., Okuno, M., Ito, M. & Yokota, S., Jan 1 2015, In : Japanese journal of clinical oncology. 45, 1, p. 88-95 8 p., hyu176.

Research output: Contribution to journal › Article

docetaxel
Medical Oncology
Non-Small Cell Lung Carcinoma
Cisplatin
Japan
10 Citations (Scopus)

Severe acute interstitial lung disease in a patient with anaplastic lymphoma kinase rearrangement-positive non-small cell lung cancer treated with alectinib

Yamamoto, Y., Okamoto, I., Otsubo, K., Iwama, E., Hamada, N., Harada, T., Takayama, K. & Nakanishi, Y., Oct 22 2015, In : Investigational New Drugs. 33, 5, p. 1148-1150 3 p.

Research output: Contribution to journal › Article

Interstitial Lung Diseases
Non-Small Cell Lung Carcinoma
Tomography
Lymphocytosis
Bronchoalveolar Lavage Fluid
6 Citations (Scopus)

Successful treatment with alectinib after crizotinib-induced esophageal ulceration

Yoneshima, Y., Okamoto, I., Takano, T., Enokizu, A., Iwama, E., Harada, T., Takayama, K. & Nakanishi, Y., Jun 1 2015, In : Lung Cancer. 88, 3, p. 349-351 3 p.

Research output: Contribution to journal › Article

Therapeutics
Protein-Tyrosine Kinases
crizotinib
CH5424802
Wounds and Injuries
12 Citations (Scopus)

Survival, quality-adjusted survival, and other clinical end points in older advanced non-small-cell lung cancer patients treated with albumin-bound paclitaxel

Langer, C. J., Hirsh, V., Okamoto, I., Lin, F. J., Wan, Y., Whiting, S., Ong, T. J., Renschler, M. F. & Botteman, M. F., Jun 30 2015, In : British journal of cancer. 113, 1, p. 20-29 10 p.

Research output: Contribution to journal › Article

Carboplatin
Non-Small Cell Lung Carcinoma
Paclitaxel
Survival
Quality of Life
56 Citations (Scopus)

The OCT4 pseudogene POU5F1B is amplified and promotes an aggressive phenotype in gastric cancer

Hayashi, H., Arao, T., Togashi, Y., Kato, H., Fujita, Y., De Velasco, M. A., Kimura, H., Matsumoto, K., Tanaka, K., Okamoto, I., Ito, A., Yamada, Y., Nakagawa, K. & Nishio, K., Jan 8 2015, In : Oncogene. 34, 2, p. 199-208 10 p.

Research output: Contribution to journal › Article

Pseudogenes
Stomach Neoplasms
Phenotype
Neoplasms
Cell Line
26 Citations (Scopus)

The pan-HER family tyrosine kinase inhibitor afatinib overcomes HER3 ligand heregulin-mediated resistance to EGFR inhibitors in non-small cell lung cancer

Yonesaka, K., Kudo, K., Nishida, S., Takahama, T., Iwasa, T., Yoshida, T., Tanaka, K., Takeda, M., Kaneda, H., Okamoto, I., Nishio, K. & Nakagawa, K., Jan 1 2015, In : Oncotarget. 6, 32, p. 33602-33611 10 p.

Research output: Contribution to journal › Article

Neuregulin-1
Non-Small Cell Lung Carcinoma
Protein-Tyrosine Kinases
Ligands
Phosphorylation
28 Citations (Scopus)

Tolerability of nintedanib (BIBF 1120) in combination with docetaxel: A phase 1 study in japanese patients with previously treated non-small-cell lung cancer

Okamoto, I., Miyazaki, M., Takeda, M., Terashima, M., Azuma, K., Hayashi, H., Kaneda, H., Kurata, T., Tsurutani, J., Seto, T., Hirai, F., Konishi, K., Sarashina, A., Yagi, N., Kaiser, R. & Nakagawa, K., Feb 6 2015, In : Journal of Thoracic Oncology. 10, 2, p. 346-352 7 p.

Research output: Contribution to journal › Article

docetaxel
Body Surface Area
Non-Small Cell Lung Carcinoma
Maximum Tolerated Dose
nintedanib
2014
38 Citations (Scopus)

Addition of bevacizumab enhances antitumor activity of erlotinib against non-small cell lung cancer xenografts depending on VEGF expression

Li, H., Takayama, K., Wang, S., Shiraishi, Y., Gotanda, K., Harada, T., Furuyama, K., Iwama, E., Ieiri, I., Okamoto, I. & Nakanishi, Y., Oct 9 2014, In : Cancer chemotherapy and pharmacology. 74, 6, p. 1297-1305 9 p.

Research output: Contribution to journal › Article

Heterografts
Non-Small Cell Lung Carcinoma
Vascular Endothelial Growth Factor A
Cells
Tumors
1 Citation (Scopus)

A phase I study of split-dose cisplatin and etoposide with concurrent accelerated hyperfractionated thoracic radiotherapy in elderly patients with limited-disease small cell lung cancer

Okamoto, K., Okamoto, I., Takeda, M., Kobayashi, S., Takeda, K., Nakamatsu, K., Nishimura, Y. & Nakagawa, K., Aug 2014, In : Japanese journal of clinical oncology. 44, 8, p. 743-748 6 p., hyu071.

Research output: Contribution to journal › Article

Small Cell Lung Carcinoma
Etoposide
Cisplatin
Radiotherapy
Thorax
327 Citations (Scopus)

Association of PD-L1 overexpression with activating EGFR mutations in surgically resected nonsmall-cell lung cancer

Azuma, K., Ota, K., Kawahara, A., Hattori, S., Iwama, E., Harada, T., Matsumoto, K., Takayama, K., Takamori, S., Kage, M., Hoshino, T., Nakanishi, Y. & Okamoto, I., Oct 1 2014, In : Annals of oncology : official journal of the European Society for Medical Oncology / ESMO. 25, 10, p. 1935-1940 6 p.

Research output: Contribution to journal › Article

erbB-1 Genes
Non-Small Cell Lung Carcinoma
Ligands
Mutation
Cell Line
16 Citations (Scopus)

Bilateral ovarian metastasis of non-small cell lung cancer with ALK rearrangement

Fujiwara, A., Higashiyama, M., Kanou, T., Tokunaga, T., Okami, J., Kodama, K., Nishino, K., Tomita, Y. & Okamoto, I., Feb 1 2014, In : Lung Cancer. 83, 2, p. 302-304 3 p.

Research output: Contribution to journal › Article

Gene Rearrangement
Non-Small Cell Lung Carcinoma
Neoplasm Metastasis
Fluorescence In Situ Hybridization
anaplastic lymphoma kinase
54 Citations (Scopus)

CRIPTO1 expression in EGFR-mutant NSCLC elicits intrinsic EGFR-inhibitor resistance

Park, K. S., Raffeld, M., Moon, Y. W., Xi, L., Bianco, C., Pham, T., Lee, L. C., Mitsudomi, T., Yatabe, Y., Okamoto, I., Subramaniam, D., Mok, T., Rosell, R., Luo, J., Salomon, D. S., Wang, Y. & Giaccone, G., Jul 1 2014, In : Journal of Clinical Investigation. 124, 7, p. 3003-3015 13 p.

Research output: Contribution to journal › Article

Non-Small Cell Lung Carcinoma
MicroRNAs
Epithelial-Mesenchymal Transition
Protein-Tyrosine Kinases
Mutation
3 Citations (Scopus)

Current status and future perspectives of cooperative study groups for lung cancer in Japan

Kawano, Y., Okamoto, I., Fukuda, H., Ohe, Y., Nakamura, S., Nakagawa, K., Hotta, K., Kiura, K., Takiguchi, Y., Saka, H., Okamoto, H., Takayama, K., Semba, H., Kobayashi, K., Kenmotsu, H., Tsuboi, M., Yamamoto, N., Nukiwa, T. & Nakanishi, Y., Nov 1 2014, In : Respiratory Investigation. 52, 6, p. 339-347 9 p.

Research output: Contribution to journal › Review article

Lung Neoplasms
Japan
Clinical Trials
Research Personnel
Therapeutics
19 Citations (Scopus)

Cystic brain metastasis in non-small-cell lung cancer with ALK rearrangement

Hayashi, H., Okamoto, I., Tanizaki, J., Tanaka, K., Okuda, T., Kato, A., Nishimura, Y. & Nakagawa, K., Jan 1 2014, In : Journal of Clinical Oncology. 32, 36, p. e122-e124 A31.

Research output: Contribution to journal › Article

Gene Rearrangement
Receptor Protein-Tyrosine Kinases
Non-Small Cell Lung Carcinoma
Brain Neoplasms
Cysts
32 Citations (Scopus)

Development of anaplastic lymphoma kinase (ALK) inhibitors and molecular diagnosis in ALK rearrangement-positive lung cancer

Iwama, E., Okamoto, I., Harada, T., Takayama, K. & Nakanishi, Y., Mar 5 2014, In : OncoTargets and Therapy. 7, p. 375-385 11 p.

Research output: Contribution to journal › Review article

Lung Neoplasms
Non-Small Cell Lung Carcinoma
anaplastic lymphoma kinase
United States Food and Drug Administration
Oncogenes
381 Citations (Scopus)

Erlotinib alone or with bevacizumab as first-line therapy in patients with advanced non-squamous non-small-cell lung cancer harbouring EGFR mutations (JO25567): An open-label, randomised, multicentre, phase 2 study

Seto, T., Kato, T., Nishio, M., Goto, K., Atagi, S., Hosomi, Y., Yamamoto, N., Hida, T., Maemondo, M., Nakagawa, K., Nagase, S., Okamoto, I., Yamanaka, T., Tajima, K., Harada, R., Fukuoka, M. & Yamamoto, N., Oct 1 2014, In : The Lancet Oncology. 15, 11, p. 1236-1244 9 p.

Research output: Contribution to journal › Article

Non-Small Cell Lung Carcinoma
Mutation
Therapeutics
Disease-Free Survival
Bevacizumab
18 Citations (Scopus)

Multiplex genomic profiling of non-small cell lung cancers from the LETS phase III trial of first-line S-1/carboplatin versus paclitaxel/carboplatin: Results of a West Japan Oncology Group study

Okamoto, I., Sakai, K., Morita, S., Yoshioka, H., Kaneda, H., Takeda, K., Hirashima, T., Kogure, Y., Kimura, T., Takahashi, T., Atagi, S., Seto, T., Sawa, T., Yamamoto, M., Satouchi, M., Okuno, M., Nagase, S., Takayama, K., Tomii, K., Maeda, T. & 8 others, Oizumi, S., Fujii, S., Akashi, Y., Nishino, K., Ebi, N., Nakagawa, K., Nakanishi, Y. & Nishio, K., Apr 2014, In : Oncotarget. 5, 8, p. 2293-2304 12 p.

Research output: Contribution to journal › Article

Carboplatin
Paclitaxel
Non-Small Cell Lung Carcinoma
Japan
Mutation
19 Citations (Scopus)

Patient-reported neuropathy and taxane-associated symptoms in a phase 3 trial of nab-paclitaxel plus carboplatin versus solvent-based paclitaxel plus carboplatin for advanced non-small-cell lung cancer

Hirsh, V., Okamoto, I., Hon, J. K., Page, R. D., Orsini, J., Sakai, H., Zhang, H., Renschler, M. F. & Socinski, M. A., Jan 1 2014, In : Journal of Thoracic Oncology. 9, 1, p. 83-90 8 p.

Research output: Contribution to journal › Article

Carboplatin
Paclitaxel
Non-Small Cell Lung Carcinoma
Peripheral Nervous System Diseases
Physicians
3 Citations (Scopus)

Phase II clinical trial of S-1 plus oral leucovorin in previously treated patients with non-small-cell lung cancer

Naito, T., Seto, T., Takeda, K., Goto, K., Okamoto, I., Nakagawa, K., Ohba, T., Murakami, H., Takahashi, T., Yamanaka, T. & Yamamoto, N., Dec 1 2014, In : Lung Cancer. 86, 3, p. 339-343 5 p.

Research output: Contribution to journal › Article

Phase II Clinical Trials
Leucovorin
Non-Small Cell Lung Carcinoma
Disease-Free Survival
Pneumatosis Cystoides Intestinalis
14 Citations (Scopus)

Phase II study of zoledronic acid combined with docetaxel for non-small-cell lung cancer: West Japan Oncology Group

Murakami, H., Yamanaka, T., Seto, T., Sugio, K., Okamoto, I., Sawa, T., Hirashima, T., Takeda, K., Atagi, S., Fukuoka, M., Nakanishi, Y., Nakagawa, K. & Yamamoto, N., Aug 2014, In : Cancer Science. 105, 8, p. 989-995 7 p.

Research output: Contribution to journal › Article

zoledronic acid
docetaxel
Non-Small Cell Lung Carcinoma
Japan
Confidence Intervals
39 Citations (Scopus)

Survival outcome assessed according to tumor response and shrinkage pattern in patients with EGFR mutation-positive non-small-cell lung cancer treated with gefitinib or erlotinib

Takeda, M., Okamoto, I. & Nakagawa, K., Feb 1 2014, In : Journal of Thoracic Oncology. 9, 2, p. 200-204 5 p.

Research output: Contribution to journal › Article

erbB-1 Genes
Non-Small Cell Lung Carcinoma
Mutation
Survival
Protein-Tyrosine Kinases
47 Citations (Scopus)

The anti-HER3 antibody patritumab abrogates cetuximab resistance mediated by heregulin in colorectal cancer cells

Kawakami, H., Okamoto, I., Yonesaka, K., Okamoto, K., Shibata, K., Shinkai, Y., Sakamoto, H., Kitano, M., Tamura, T., Nishio, K. & Nakagawa, K., Jan 1 2014, In : Oncotarget. 5, 23, p. 11847-11856 10 p.

Research output: Contribution to journal › Article

Neuregulin-1
Anti-Idiotypic Antibodies
Colorectal Neoplasms
Phosphorylation
Cetuximab
72 Citations (Scopus)

Tyrosine phosphoproteomics identifies both codrivers and cotargeting strategies for T790M-related EGFR-TKI resistance in non-small cell lung cancer

Yoshida, T., Zhang, G., Smith, M. A., Lopez, A. S., Bai, Y., Li, J., Fang, B., Koomen, J., Rawal, B., Fisher, K. J., Chen, A. Y., Kitano, M., Morita, Y., Yamaguchi, H., Shibata, K., Okabe, T., Okamoto, I., Nakagawa, K. & Haura, E. B., Aug 1 2014, In : Clinical Cancer Research. 20, 15, p. 4059-4074 16 p.

Research output: Contribution to journal › Article

Non-Small Cell Lung Carcinoma
Protein-Tyrosine Kinases
Tyrosine
src-Family Kinases
Phosphorylation
2013
14 Citations (Scopus)

A phase I, pharmacokinetic and pharmacodynamic study of nimotuzumab in Japanese patients with advanced solid tumors

Okamoto, W., Yoshino, T., Takahashi, T., Okamoto, I., Ueda, S., Tsuya, A., Boku, N., Nishio, K., Fukuoka, M., Yamamoto, N. & Nakagawa, K., Nov 1 2013, In : Cancer chemotherapy and pharmacology. 72, 5, p. 1063-1071 9 p.

Research output: Contribution to journal › Article

Pharmacodynamics
Pharmacokinetics
Epidermal Growth Factor Receptor
Toxicity
Tumors
1 Citation (Scopus)

A phase II study of cisplatin /S-1 in patients with carcinomas of unknown primary site

Tsuya, A., Kurata, T., Tamiya, A., Okamoto, I., Ueda, S., Sakai, D., Sugimoto, N., Matsumoto, K., Goto, I., Yamamoto, N., Fukuoka, M. & Nakagawa, K., Dec 1 2013, In : Investigational New Drugs. 31, 6, p. 1568-1572 5 p.

Research output: Contribution to journal › Article

Cisplatin
Carcinoma
Combination Drug Therapy
Appointments and Schedules
Febrile Neutropenia
1 Citation (Scopus)

A phase i study of S-1 with concurrent radiotherapy in elderly patients with locally advanced non-small cell lung cancer

Hasegawa, Y., Okamoto, I., Takezawa, K., Miyazaki, M., Tsurutani, J., Yonesaka, K., Morinaga, R., Tsuya, A., Terashima, M., Kudoh, T., Azuma, K., Kurata, T., Nishikawa, T., Fukuoka, M., Nishimura, Y. & Nakagawa, K., Jun 1 2013, In : Investigational New Drugs. 31, 3, p. 599-604 6 p.

Research output: Contribution to journal › Article

Non-Small Cell Lung Carcinoma
Radiotherapy
Thorax
Stomatitis
Pneumonia
1 Citation (Scopus)

Bronchoscopic findings for bevacizumab-related pulmonary hemorrhage in advanced non-small cell lung cancer

Okamoto, K., Okamoto, I., Miyazaki, M., Tanaka, K., Kaneda, H. & Nakagawa, K., Oct 1 2013, In : Investigational New Drugs. 31, 5, p. 1364-1366 3 p.

Research output: Contribution to journal › Article

Bronchoscopy
Non-Small Cell Lung Carcinoma
Hemorrhage
Lung
Hemoptysis
62 Citations (Scopus)

Clinical impact of continued crizotinib administration after isolated central nervous system progression in patients with lung cancer positive for ALK rearrangement

Takeda, M., Okamoto, I. & Nakagawa, K., May 1 2013, In : Journal of Thoracic Oncology. 8, 5, p. 654-657 4 p.

Research output: Contribution to journal › Article

Lung Neoplasms
Central Nervous System
Radiotherapy
Non-Small Cell Lung Carcinoma
Disease Progression
13 Citations (Scopus)

Clinical response to crizotinib retreatment after acquisition of drug resistance

Matsuoka, H., Kurata, T., Okamoto, I., Kaneda, H., Tanaka, K. & Nakagawa, K., Jul 1 2013, In : Journal of Clinical Oncology. 31, 19

Research output: Contribution to journal › Article

Fusion Oncogene Proteins
Serine Endopeptidases
Neoplasm Drug Resistance
Drug Administration Schedule
Antineoplastic Combined Chemotherapy Protocols
41 Citations (Scopus)

Efficacy and safety analysis according to histology for s-1 in combination with carboplatin as first-line chemotherapy in patients with advanced non-small-cell lung cancer: Updated results of the west japan oncology group lets study

Yoshioka, H., Okamoto, I., Morita, S., Ando, M., Takeda, K., Seto, T., Yamamoto, N., Saka, H., Atagi, S., Hirashima, T., Kudoh, S., Satouchi, M., Ikeda, N., Iwamoto, Y., Sawa, T., Nakanishi, Y. & Nakagawa, K., May 1 2013, In : Annals of Oncology. 24, 5, p. 1326-1331 6 p., mds629.

Research output: Contribution to journal › Article

Carboplatin
Non-Small Cell Lung Carcinoma
Histology
Japan
Safety
26 Citations (Scopus)

Efficacy and safety of weekly nab-paclitaxel plus carboplatin in patients with advanced non-small cell lung cancer

Satouchi, M., Okamoto, I., Sakai, H., Yamamoto, N., Ichinose, Y., Ohmatsu, H., Nogami, N., Takeda, K., Mitsudomi, T., Kasahara, K. & Negoro, S., Jul 1 2013, In : Lung Cancer. 81, 1, p. 97-101 5 p.

Research output: Contribution to journal › Article

Carboplatin
Non-Small Cell Lung Carcinoma
Safety
Paclitaxel
Thrombocytopenia
1 Citation (Scopus)

Erratum: Pemetrexed and carboplatin followed by pemetrexed maintenance therapy in chemo-naïve patients with advanced nonsquamous non-small-cell lung cancer (Investigational New Drugs (DOI 10.1007/s10637-013-9941-z))

Okamoto, I., Aoe, K., Kato, T., Hosomi, Y., Yokoyama, A., Imamura, F., Kiura, K., Hirashima, T., Nishio, M., Nogami, N., Okamoto, H., Saka, H., Yamamoto, N., Yoshizuka, N., Sekiguchi, R., Kiyosawa, K., Nakagawa, K. & Tamura, T., Oct 1 2013, In : Investigational New Drugs. 31, 5, p. 1395-1396 2 p.

Research output: Contribution to journal › Comment/debate

Pemetrexed
Investigational Drugs
Carboplatin
Non-Small Cell Lung Carcinoma
Therapeutics
26 Citations (Scopus)

Histology and smoking status predict survival of patients with advanced non-small-cell lung cancer: Results of west Japan oncology group (WJOG) study 3906L

Kogure, Y., Ando, M., Saka, H., Chiba, Y., Yamamoto, N., Asami, K., Hirashima, T., Seto, T., Nagase, S., Otsuka, K., Yanagihara, K., Takeda, K., Okamoto, I., Aoki, T., Takayama, K., Yamasaki, M., Kudoh, S., Katakami, N., Miyazaki, M. & Nakagawa, K., Jun 2013, In : Journal of Thoracic Oncology. 8, 6, p. 753-758 6 p.

Research output: Contribution to journal › Article

Non-Small Cell Lung Carcinoma
Histology
Japan
Smoking
Adenocarcinoma
19 Citations (Scopus)

Human papillomavirus DNA and p16 expression in Japanese patients with oropharyngeal squamous cell carcinoma

Kawakami, H., Okamoto, I., Terao, K., Sakai, K., Suzuki, M., Ueda, S., Tanaka, K., Kuwata, K., Morita, Y., Ono, K., Nishio, K., Nishimura, Y., Doi, K. & Nakagawa, K., Dec 2013, In : Cancer Medicine. 2, 6, p. 933-941 9 p.

Research output: Contribution to journal › Article

Squamous Cell Carcinoma
DNA
p16 Genes
Methylation
Cisplatin
65 Citations (Scopus)

MET amplification as a potential therapeutic target in gastric cancer

Kawakami, H., Okamoto, I., Arao, T., Okamoto, W., Matsumoto, K., Taniguchi, H., Kuwata, K., Yamaguchi, H., Nishio, K., Nakagawa, K. & Yamada, Y., 2013, In : Oncotarget. 4, 1, p. 9-17 9 p.

Research output: Contribution to journal › Article

Stomach Neoplasms
Protein-Tyrosine Kinases
Therapeutics
Polymerase Chain Reaction
Gene Dosage
15 Citations (Scopus)

Molecularly targeted approaches herald a new era of non-small-cell lung cancer treatment

Kaneda, H., Yoshida, T. & Okamoto, I., May 29 2013, In : Cancer Management and Research. 5, 1, p. 91-101 11 p.

Research output: Contribution to journal › Review article

Non-Small Cell Lung Carcinoma
Epidermal Growth Factor Receptor
Protein-Tyrosine Kinases
Mutation
erbB-1 Genes
27 Citations (Scopus)

Pemetrexed and carboplatin followed by pemetrexed maintenance therapy in chemo-naïve patients with advanced nonsquamous non-small-cell lung cancer

Okamoto, I., Aoe, K., Kato, T., Hosomi, Y., Yokoyama, A., Imamura, F., Kiura, K., Hirashima, T., Nishio, M., Nogami, N., Okamoto, H., Saka, H., Yamamoto, N., Yoshizuka, N., Sekiguchi, R., Kiyosawa, K., Nakagawa, K. & Tamura, T., Jan 1 2013, In : Investigational New Drugs. 31, 5, p. 1275-1282 8 p.

Research output: Contribution to journal › Article

Pemetrexed
Carboplatin
Non-Small Cell Lung Carcinoma
Epidermal Growth Factor Receptor
Therapeutics
32 Citations (Scopus)

Perturbation of the mutated EGFR interactome identifies vulnerabilities and resistance mechanisms

Li, J., Bennett, K., Stukalov, A., Fang, B., Zhang, G., Yoshida, T., Okamoto, I., Kim, J. Y., Song, L., Bai, Y., Qian, X., Rawal, B., Schell, M., Grebien, F., Winter, G., Rix, U., Eschrich, S., Colinge, J., Koomen, J., Superti-Furga, G. & 1 others, Haura, E. B., Nov 5 2013, In : Molecular Systems Biology. 9, 705.

Research output: Contribution to journal › Article

Growth Factors
resistance mechanisms
Vulnerability
Epidermal Growth Factor Receptor
Receptor
8 Citations (Scopus)

Phase 2 study of S-1 and carboplatin plus bevacizumab followed by maintenance S-1 and bevacizumab for chemotherapy-naive patients with advanced nonsquamous non-small cell lung cancer

Urata, Y., Okamoto, I., Takeda, M., Hattori, Y., Okuno, K., Shimada, T., Kurata, T., Kaneda, H., Miyazaki, M., Terashima, M., Tanaka, K., Morita, S., Nakagawa, K., Negoro, S. & Satouchi, M., Jun 15 2013, In : Cancer. 119, 12, p. 2275-2281 7 p.

Research output: Contribution to journal › Article

Carboplatin
Non-Small Cell Lung Carcinoma
Maintenance
Drug Therapy
Disease Progression
5 Citations (Scopus)

Phase i and pharmacokinetic study of gefitinib and S-1 combination therapy for advanced adenocarcinoma of the lung

Kiyota, H., Okamoto, I., Takeda, M., Daga, H., Naito, T., Miyazaki, M., Okada, H., Hayashi, H., Tanaka, K., Terashima, M., Azuma, K., Murakami, H., Takeda, K., Yamamoto, N. & Nakagawa, K., Apr 1 2013, In : Cancer Chemotherapy and Pharmacology. 71, 4, p. 859-865 7 p.

Research output: Contribution to journal › Article

Pharmacokinetics
Therapeutics
Chemotherapy
Aspartate Aminotransferases
Disease-Free Survival
8 Citations (Scopus)

Phase II study of bi-weekly irinotecan for patients with previously treated HER2-negative metastatic breast cancer: KMBOG0610B

Hayashi, H., Tsurutani, J., Satoh, T., Masuda, N., Okamoto, W., Morinaga, R., Terashima, M., Miyazaki, M., Okamoto, I., Nishida, Y., Tominaga, S., Tokunaga, Y., Yamaguchi, M., Sakamoto, J., Nakayama, T. & Nakagawa, K., Apr 1 2013, In : Breast Cancer. 20, 2, p. 131-136 6 p.

Research output: Contribution to journal › Article

irinotecan
Breast Neoplasms
Anthracyclines
Taxoids
Topoisomerase I Inhibitors
1 Citation (Scopus)

Phase I pharmacokinetic study of S-1 granules and nedaplatin for advanced head and neck cancer

Hayashi, H., Okamoto, I., Ueda, S., Tanaka, K., Okamoto, K., Kawakami, H., Nishina, S., Takeda, M., Fujisaka, Y., Satoh, T., Terao, K., Nishimura, Y., Doi, K. & Nakagawa, K., Dec 1 2013, In : Anticancer research. 33, 12, p. 5699-5706 8 p.

Research output: Contribution to journal › Article

Head and Neck Neoplasms
Pharmacokinetics
Neutropenia
Endpoint Determination
nedaplatin
12 Citations (Scopus)

Postprogression survival for first-line chemotherapy in patients with advanced gastric cancer

Kawakami, H., Okamoto, I., Hayashi, H., Taguri, M., Morita, S. & Nakagawa, K., Sep 1 2013, In : European Journal of Cancer. 49, 14, p. 3003-3009 7 p.

Research output: Contribution to journal › Article

Stomach Neoplasms
Drug Therapy
Survival
Disease-Free Survival
20 Citations (Scopus)

Postprogression survival in patients with advanced non-small-cell lung cancer who receive second-line or third-line chemotherapy

Hayashi, H., Okamoto, I., Taguri, M., Morita, S. & Nakagawa, K., Jul 15 2013, In : Clinical Lung Cancer. 14, 3, p. 261-266 6 p.

Research output: Contribution to journal › Article

Non-Small Cell Lung Carcinoma
Drug Therapy
Survival
Disease-Free Survival
Therapeutics