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Research Output 1998 2019

2012
32 Citations (Scopus)

Combined effect of ALK and MEK inhibitors in EML4-ALK-positive non-small-cell lung cancer cells

Tanizaki, J., Okamoto, I., Takezawa, K., Sakai, K., Azuma, K., Kuwata, K., Yamaguchi, H., Hatashita, E., Nishio, K., Janne, P. A. & Nakagawa, K., Feb 14 2012, In : British journal of cancer. 106, 4, p. 763-767 5 p.

Research output: Contribution to journalArticle

Mitogen-Activated Protein Kinase Kinases
Non-Small Cell Lung Carcinoma
MAP Kinase Signaling System
Apoptosis
Phosphorylation
11 Citations (Scopus)
Non-Small Cell Lung Carcinoma
Therapeutics
Oncogenes
Protein-Tyrosine Kinases
MAP4

EGFR

Okamoto, K. & Okamoto, I., Dec 1 2012, In : Respiration and Circulation. 60, 12, p. 1215-1220 6 p.

Research output: Contribution to journalReview article

7 Citations (Scopus)

Feasibility study of two schedules of sunitinib in combination with pemetrexed in patients with advanced solid tumors

Okamoto, I., Shimizu, T., Miyazaki, M., Tsurutani, J., Ichikawa, Y., Terashima, M., Takeda, M., Fumita, S., Ohki, E., Kimura, N., Hashimoto, J. & Nakagawa, K., Apr 1 2012, In : Investigational New Drugs. 30, 2, p. 639-646 8 p.

Research output: Contribution to journalArticle

Pemetrexed
Feasibility Studies
Appointments and Schedules
Neoplasms
Platelet-Derived Growth Factor Receptors

General evidence for the efficacy of maintenance therapy

Tanaka, K. & Okamoto, I., 2012, In : Japanese Journal of Chest Diseases. 71, 10, p. 964-971 8 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Maintenance
Therapeutics
Survival
9 Citations (Scopus)
docetaxel
Platinum
Non-Small Cell Lung Carcinoma
Disease Progression
Drug Therapy

Marked response to both S-1 and pemetrexed in a patient with echinoderm microtubule-associated protein-like 4-anaplastic lymphoma kinase-positive lung adenocarcinoma

Kaneda, H., Okamoto, I., Sakai, K., Tanizaki, J., Takeda, M., Nishio, K. & Nakagawa, K., Sep 1 2012, In : Acta Oncologica. 51, 7, p. 942-944 3 p.

Research output: Contribution to journalLetter

Antineoplastic Antimetabolites
Serine Endopeptidases
Pemetrexed
Oxonic Acid
Glutamates
48 Citations (Scopus)

Overcoming erlotinib resistance in EGFR mutation-positive non-small cell lung cancer cells by targeting survivin

Okamoto, K., Okamoto, I., Hatashita, E., Kuwata, K., Yamaguchi, H., Kita, A., Yamanaka, K., Ono, M. & Nakagawa, K., Jan 1 2012, In : Molecular Cancer Therapeutics. 11, 1, p. 204-213 10 p.

Research output: Contribution to journalArticle

Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
Mutation
Protein-Tyrosine Kinases
Apoptosis
5 Citations (Scopus)

Perirenal hematoma associated with bevacizumab treatment

Hayashi, H., Okamoto, I. & Nakagawa, K., Apr 1 2012, In : Investigational New Drugs. 30, 2, p. 808-809 2 p.

Research output: Contribution to journalArticle

Hematoma
Therapeutics
Hemorrhage
Drug Therapy
Rectal Neoplasms
2 Citations (Scopus)

Pharmacokinetics of docetaxel in a patient with non-small cell lung cancer undergoing continuous ambulatory peritoneal dialysis

Kaneda, H., Okamoto, I. & Nakagawa, K., Jan 1 2012, In : Journal of Thoracic Oncology. 7, 3, p. 621-622 2 p.

Research output: Contribution to journalArticle

docetaxel
Taxoids
Continuous Ambulatory Peritoneal Dialysis
Tissue Distribution
Non-Small Cell Lung Carcinoma
8 Citations (Scopus)

Phase I clinical study of the angiogenesis inhibitor TSU-68 combined with carboplatin and paclitaxel in chemotherapy-naive patients with advanced non-small cell lung cancer

Okamoto, I., Yoshioka, H., Takeda, K., Satouchi, M., Yamamoto, N., Seto, T., Kasahara, K., Miyazaki, M., Kitamura, R., Ohyama, A., Hokoda, N., Nakayama, H., Yoshihara, E. & Nakagawa, K., Jan 1 2012, In : Journal of Thoracic Oncology. 7, 2, p. 427-433 7 p.

Research output: Contribution to journalArticle

Angiogenesis Inhibitors
Carboplatin
Paclitaxel
Non-Small Cell Lung Carcinoma
Drug Therapy
48 Citations (Scopus)

Postprogression survival for first-line chemotherapy of patients with advanced non-small-cell lung cancer

Hayashi, H., Okamoto, I., Morita, S., Taguri, M. & Nakagawa, K., Jun 6 2012, In : Annals of Oncology. 23, 6, p. 1537-1541 5 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Drug Therapy
Survival
Disease-Free Survival
8 Citations (Scopus)

Reversible posterior leukoencephalopathy syndrome and trastuzumab

Kaneda, H., Okamoto, I., Satoh, T. & Nakagawa, K., Aug 1 2012, In : Investigational New Drugs. 30, 4, p. 1766-1767 2 p.

Research output: Contribution to journalArticle

Posterior Leukoencephalopathy Syndrome
Hypertension
Stomach Neoplasms
Brain
Vascular Endothelial Growth Factor A
10 Citations (Scopus)

Safety and pharmacokinetic study of nab-paclitaxel plus carboplatin in chemotherapy-naïve patients with advanced non-small cell lung cancer

Okamoto, I., Yamamoto, N., Kubota, K., Ohe, Y., Nogami, N., Murakami, H., Yamaya, H., Ono, K. & Nakagawa, K., Jun 1 2012, In : Investigational New Drugs. 30, 3, p. 1132-1137 6 p.

Research output: Contribution to journalArticle

Carboplatin
Non-Small Cell Lung Carcinoma
Nanoparticles
Pharmacokinetics
Area Under Curve
22 Citations (Scopus)

SRPX2 is a novel chondroitin sulfate proteoglycan that is overexpressed in gastrointestinal cancer

Tanaka, K., Arao, T., Tamura, D., Aomatsu, K., Furuta, K., Matsumoto, K., Kaneda, H., Kudo, K., Fujita, Y., Kimura, H., Yanagihara, K., Yamada, Y., Okamoto, I., Nakagawa, K. & Nishio, K., Jan 5 2012, In : PloS one. 7, 1, e27922.

Research output: Contribution to journalArticle

sushi
Chondroitin Sulfate Proteoglycans
chondroitin sulfate
Gastrointestinal Neoplasms
proteoglycans
5 Citations (Scopus)

Successful long-term treatment with pemetrexed of NSCLC associated with EML4-ALK and low thymidylate synthase expression

Takeda, M., Okamoto, I., Sakai, K., Tanaka, K., Terashima, M., Nishio, K. & Nakagawa, K., Mar 2012, In : Clinical Lung Cancer. 13, 2, p. 157-159 3 p.

Research output: Contribution to journalArticle

Fusion Oncogene Proteins
Pemetrexed
Pleural Neoplasms
Signet Ring Cell Carcinoma
Glutamates
389 Citations (Scopus)

Weekly nab-paclitaxel in combination with carboplatin versus solvent-based paclitaxel plus carboplatin as first-line therapy in patients with advanced non-small-cell lung cancer: Final results of a phase III trial

Socinski, M. A., Bondarenko, I., Karaseva, N. A., Makhson, A. M., Vynnychenko, I., Okamoto, I., Hon, J. K., Hirsh, V., Bhar, P., Zhang, H., Iglesias, J. L. & Renschler, M. F., Jun 10 2012, In : Journal of Clinical Oncology. 30, 17, p. 2055-2062 8 p.

Research output: Contribution to journalArticle

Carboplatin
Paclitaxel
Non-Small Cell Lung Carcinoma
Histology
Therapeutics
2011
331 Citations (Scopus)

Activation of ERBB2 signaling causes resistance to the EGFR-directed therapeutic antibody cetuximab

Yonesaka, K., Zejnullahu, K., Okamoto, I., Satoh, T., Cappuzzo, F., Souglakos, J., Ercan, D., Rogers, A., Roncalli, M., Takeda, M., Fujisaka, Y., Philips, J., Shimizu, T., Maenishi, O., Cho, Y., Sun, J., Destro, A., Taira, K., Takeda, K., Okabe, T. & 12 others, Swanson, J., Itoh, H., Takada, M., Lifshits, E., Okuno, K., Engelman, J. A., Shivdasani, R. A., Nishio, K., Fukuoka, M., Varella-Garcia, M., Nakagawa, K. & Jänne, P. A., Sep 7 2011, In : Science Translational Medicine. 3, 99

Research output: Contribution to journalArticle

Antibodies
Neuregulin-1
Therapeutics
Mitogen-Activated Protein Kinase 3
Mitogen-Activated Protein Kinase 1

Activation of ERBB2 signaling causes resistance to the EGFR-directed therapeutic antibody cetuximab.

Yonesaka, K., Zejnullahu, K., Okamoto, I., Satoh, T., Cappuzzo, F., Souglakos, J., Ercan, D., Rogers, A., Roncalli, M., Takeda, M., Fujisaka, Y., Philips, J., Shimizu, T., Maenishi, O., Cho, Y., Sun, J., Destro, A., Taira, K., Takeda, K., Okabe, T. & 12 others, Swanson, J., Itoh, H., Takada, M., Lifshits, E., Okuno, K., Engelman, J. A., Shivdasani, R. A., Nishio, K., Fukuoka, M., Varella-Garcia, M., Nakagawa, K. & Jänne, P. A., Sep 7 2011, In : Science Translational Medicine. 3, 99

Research output: Contribution to journalArticle

Antibodies
Neuregulin-1
Therapeutics
Mitogen-Activated Protein Kinase 3
Mitogen-Activated Protein Kinase 1
40 Citations (Scopus)

Activin A inhibits vascular endothelial cell growth and suppresses tumour angiogenesis in gastric cancer

Kaneda, H., Arao, T., Matsumoto, K., De Velasco, M. A., Tamura, D., Aomatsu, K., Kudo, K., Sakai, K., Nagai, T., Fujita, Y., Tanaka, K., Yanagihara, K., Yamada, Y., Okamoto, I., Nakagawa, K. & Nishio, K., Oct 11 2011, In : British journal of cancer. 105, 8, p. 1210-1217 8 p.

Research output: Contribution to journalArticle

Stomach Neoplasms
Endothelial Cells
Human Umbilical Vein Endothelial Cells
Growth
Neoplasms
26 Citations (Scopus)

Differential roles of STAT3 depending on the mechanism of STAT3 activation in gastric cancer cells

Okamoto, W., Okamoto, I., Arao, T., Yanagihara, K., Nishio, K. & Nakagawa, K., Jul 26 2011, In : British journal of cancer. 105, 3, p. 407-412 6 p.

Research output: Contribution to journalArticle

STAT3 Transcription Factor
Transcriptional Activation
Stomach Neoplasms
Cell Movement
Protein-Tyrosine Kinases
66 Citations (Scopus)

Differential roles of trans-phosphorylated EGFR, HER2, HER3, and RET as heterodimerisation partners of MET in lung cancer with MET amplification

Tanizaki, J., Okamoto, I., Sakai, K. & Nakagawa, K., Sep 6 2011, In : British journal of cancer. 105, 6, p. 807-813 7 p.

Research output: Contribution to journalArticle

Epidermal Growth Factor Receptor
Lung Neoplasms
Receptor Protein-Tyrosine Kinases
Immunoprecipitation
Cell Migration Assays

Erlotinib in non-small cell lung cancer

Takeda, M. & Okamoto, I., Jan 1 2011, In : Japanese Journal of Cancer and Chemotherapy. 38, 6, p. 896-900 5 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Protein-Tyrosine Kinases
Quinazolines
Mutation
Disease-Free Survival
25 Citations (Scopus)

High-dose dexamethasone plus antihistamine prevents colorectal cancer patients treated with modified FOLFOX6 from hypersensitivity reactions induced by oxaliplatin

Kidera, Y., Satoh, T., Ueda, S., Okamoto, W., Okamoto, I., Fumita, S., Yonesaka, K., Hayashi, H., Makimura, C., Okamoto, K., Kiyota, H., Tsurutani, J., Miyazaki, M., Yoshinaga, M., Fujiwara, K., Yamazoe, Y., Moriyama, K., Tsubaki, M., Chiba, Y., Nishida, S. & 1 others, Nakagawa, K., Jun 1 2011, In : International Journal of Clinical Oncology. 16, 3, p. 244-249 6 p.

Research output: Contribution to journalArticle

oxaliplatin
Histamine Antagonists
Dexamethasone
Colorectal Neoplasms
Hypersensitivity
9 Citations (Scopus)

Malignant pleural effusion from lung adenocarcinoma treated by gefitinib

Kubo, A., Koh, Y., Kawaguchi, T., Isa, S. I., Okamoto, I., Fukuoka, J., Kusunoki, Y., Kitaichi, M., Takada, M. & Nakagawa, K., Apr 12 2011, In : Internal Medicine. 50, 7, p. 745-748 4 p.

Research output: Contribution to journalArticle

Malignant Pleural Effusion
Apoptosis
Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
Drainage
90 Citations (Scopus)

MET tyrosine kinase inhibitor crizotinib (PF-02341066) shows differential antitumor effects in non-small cell lung cancer according to MET alterations

Tanizaki, J., Okamoto, I., Okamoto, K., Takezawa, K., Kuwata, K., Yamaguchi, H. & Nakagawa, K., Jan 1 2011, In : Journal of Thoracic Oncology. 6, 10, p. 1624-1631 8 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Protein-Tyrosine Kinases
Mutation
Lung Neoplasms
Apoptosis
15 Citations (Scopus)

Phase I study of dasatinib (BMS-354825) in Japanese patients with solid tumors

Takahashi, S., Miyazaki, M., Okamoto, I., Ito, Y., Ueda, K., Seriu, T., Nakagawa, K. & Hatake, K., Nov 1 2011, In : Cancer Science. 102, 11, p. 2058-2064 7 p.

Research output: Contribution to journalArticle

Maximum Tolerated Dose
Neoplasms
Pleural Effusion
Fatigue
Anemia
102 Citations (Scopus)

Role of ERK-BIM and STAT3-survivin signaling pathways in ALK inhibitor-induced apoptosis in EML4-ALK-positive lung cancer

Takezawa, K., Okamoto, I., Nishio, K., Jänne, P. A. & Nakagawa, K., Apr 15 2011, In : Clinical Cancer Research. 17, 8, p. 2140-2148 9 p.

Research output: Contribution to journalArticle

Extracellular Signal-Regulated MAP Kinases
Lung Neoplasms
Apoptosis
NIH 3T3 Cells
Up-Regulation
44 Citations (Scopus)

Roles of BIM induction and survivin downregulation in lapatinib-induced apoptosis in breast cancer cells with HER2 amplification

Tanizaki, J., Okamoto, I., Fumita, S., Okamoto, W., Nishio, K. & Nakagawa, K., Sep 29 2011, In : Oncogene. 30, 39, p. 4097-4106 10 p.

Research output: Contribution to journalArticle

Phosphatidylinositol 3-Kinase
Down-Regulation
Apoptosis
Breast Neoplasms
Mutation
27 Citations (Scopus)

S-1 plus cisplatin with concurrent radiotherapy for locally advanced non-small cell lung cancer: a multi-institutional phase II trial (West Japan Thoracic Oncology Group 3706).

Ichinose, Y., Seto, T., Sasaki, T., Yamanaka, T., Okamoto, I., Takeda, K., Tanaka, M., Katakami, N., Sawa, T., Kudoh, S., Saka, H., Nishimura, Y., Nakagawa, K. & Fukuoka, M., Jan 1 2011, In : Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer. 6, 12, p. 2069-2075 7 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Cisplatin
Japan
Radiotherapy
Thorax
43 Citations (Scopus)

Single-agent gefitinib with concurrent radiotherapy for locally advanced non-small cell lung cancer harboring mutations of the epidermal growth factor receptor

Okamoto, I., Takahashi, T., Okamoto, H., Nakagawa, K., Watanabe, K., Nakamatsu, K., Nishimura, Y., Fukuoka, M. & Yamamoto, N., May 1 2011, In : Lung Cancer. 72, 2, p. 199-204 6 p.

Research output: Contribution to journalArticle

Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
Radiotherapy
Mutation
erbB-1 Genes
37 Citations (Scopus)

Switching addictions between HER2 and FGFR2 in HER2-positive breast tumor cells: FGFR2 as a potential target for salvage after lapatinib failure

Azuma, K., Tsurutani, J., Sakai, K., Kaneda, H., Fujisaka, Y., Takeda, M., Watatani, M., Arao, T., Satoh, T., Okamoto, I., Kurata, T., Nishio, K. & Nakagawa, K., Apr 1 2011, In : Biochemical and Biophysical Research Communications. 407, 1, p. 219-224 6 p.

Research output: Contribution to journalArticle

Salvaging
Tumors
Cells
Breast Neoplasms
Genes
25 Citations (Scopus)

Thymidylate synthase and dihydropyrimidine dehydrogenase expression levels are associated with response to S-1 plus carboplatin in advanced non-small cell lung cancer

Takeda, M., Okamoto, I., Hirabayashi, N., Kitano, M. & Nakagawa, K., Jul 1 2011, In : Lung Cancer. 73, 1, p. 103-109 7 p.

Research output: Contribution to journalArticle

Dihydrouracil Dehydrogenase (NADP)
Thymidylate Synthase
Carboplatin
Non-Small Cell Lung Carcinoma
Orotate Phosphoribosyltransferase
120 Citations (Scopus)

Thymidylate synthase as a determinant of pemetrexed sensitivity in non-small cell lung cancer

Takezawa, K., Okamoto, I., Okamoto, W., Takeda, M., Sakai, K., Tsukioka, S., Kuwata, K., Yamaguchi, H., Nishio, K. & Nakagawa, K., May 10 2011, In : British journal of cancer. 104, 10, p. 1594-1601 8 p.

Research output: Contribution to journalArticle

Pemetrexed
Thymidylate Synthase
Non-Small Cell Lung Carcinoma
Neoplasms
Folic Acid Antagonists
2010
56 Citations (Scopus)

De novo resistance to epidermal growth factor receptor-tyrosine kinase inhibitors in EGFR mutation-positive patients with non-small cell lung cancer

Takeda, M., Okamoto, I., Fujita, Y., Arao, T., Ito, H., Fukuoka, M., Nishio, K. & Nakagawa, K., Jan 1 2010, In : Journal of Thoracic Oncology. 5, 3, p. 399-400 2 p.

Research output: Contribution to journalArticle

Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
Protein-Tyrosine Kinases
Mutation
erbB-1 Genes
11 Citations (Scopus)

Dose-escalation study of pemetrexed in combination with carboplatin followed by pemetrexed maintenance therapy for advanced non-small cell lung cancer

Okamoto, I., Takeda, K., Daga, H., Miyazaki, M., Yonesaka, K., Kiyota, H., Tsurutani, J., Ueda, S., Ichikawa, Y., Takeda, M., Sekiguchi, R., Tominaga, K., Enatsu, S., Nambu, Y. & Nakagawa, K., Nov 1 2010, In : Lung Cancer. 70, 2, p. 168-173 6 p.

Research output: Contribution to journalArticle

Pemetrexed
Carboplatin
Non-Small Cell Lung Carcinoma
Therapeutics
Confidence Intervals
49 Citations (Scopus)

Effects of Src inhibitors on cell growth and epidermal growth factor receptor and MET signaling in gefitinib-resistant non-small cell lung cancer cells with acquired MET amplification

Yoshida, T., Okamoto, I., Okamoto, W., Hatashita, E., Yamada, Y., Kuwata, K., Nishio, K., Fukuoka, M., Jänne, P. A. & Nakagawa, K., Jan 1 2010, In : Cancer Science. 101, 1, p. 167-172 6 p.

Research output: Contribution to journalArticle

Growth Inhibitors
Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
gefitinib
Mutation
58 Citations (Scopus)

Enhanced anticancer effect of the combination of BIBW2992 and thymidylate synthase-targeted agents in non-small cell lung cancer with the T790M mutation of epidermal growth factor receptor

Takezawa, K., Okamoto, I., Tanizaki, J., Kuwata, K., Yamaguchi, H., Fukuoka, M., Nishio, K. & Nakagawa, K., Jun 2010, In : Molecular Cancer Therapeutics. 9, 6, p. 1647-1656 10 p.

Research output: Contribution to journalArticle

Thymidylate Synthase
Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
Pemetrexed
Mutation
59 Citations (Scopus)

Epidermal growth factor receptor in relation to tumor development: EGFR-targeted anticancer therapy

Okamoto, I., Jan 1 2010, In : FEBS Journal. 277, 2, p. 309-315 7 p.

Research output: Contribution to journalShort survey

Epidermal Growth Factor Receptor
Tumors
Neoplasms
Protein-Tyrosine Kinases
Therapeutics
116 Citations (Scopus)

FOXQ1 is overexpressed in colorectal cancer and enhances tumorigenicity and tumor growth

Kaneda, H., Arao, T., Tanaka, K., Tamura, D., Aomatsu, K., Kudo, K., Sakai, K., De Velasco, M. A., Matsumoto, K., Fujita, Y., Yamada, Y., Tsurutani, J., Okamoto, I., Nakagawa, K. & Nishio, K., Mar 1 2010, In : Cancer Research. 70, 5, p. 2053-2063 11 p.

Research output: Contribution to journalArticle

Colorectal Neoplasms
Growth
Neoplasms
Microarray Analysis
Gastric Mucins
2772 Citations (Scopus)

Gefitinib versus cisplatin plus docetaxel in patients with non-small-cell lung cancer harbouring mutations of the epidermal growth factor receptor (WJTOG3405): an open label, randomised phase 3 trial

Mitsudomi, T., Morita, S., Yatabe, Y., Negoro, S., Okamoto, I., Tsurutani, J., Seto, T., Satouchi, M., Tada, H., Hirashima, T., Asami, K., Katakami, N., Takada, M., Yoshioka, H., Shibata, K., Kudoh, S., Shimizu, E., Saito, H., Toyooka, S., Nakagawa, K. & 1 others, Fukuoka, M., Feb 1 2010, In : The Lancet Oncology. 11, 2, p. 121-128 8 p.

Research output: Contribution to journalArticle

docetaxel
Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
Cisplatin
Mutation
48 Citations (Scopus)

Identification of c-Src as a potential therapeutic target for gastric cancer and of MET activation as a cause of resistance to c-Src inhibition

Okamoto, W., Okamoto, I., Yoshida, T., Okamoto, K., Takezawa, K., Hatashita, E., Yamada, Y., Kuwata, K., Arao, T., Yanagihara, K., Fukuoka, M., Nishio, K. & Nakagawa, K., May 1 2010, In : Molecular Cancer Therapeutics. 9, 5, p. 1188-1197 10 p.

Research output: Contribution to journalArticle

Stomach Neoplasms
Cell Line
Extracellular Signal-Regulated MAP Kinases
Therapeutics
Apoptosis
27 Citations (Scopus)

Identification of thymidylate synthase as a potential therapeutic target for lung cancer

Takezawa, K., Okamoto, I., Tsukioka, S., Uchida, J., Kiniwa, M., Fukuoka, M. & Nakagawa, K., Jul 27 2010, In : British journal of cancer. 103, 3, p. 354-361 8 p.

Research output: Contribution to journalArticle

Thymidylate Synthase
Lung Neoplasms
Therapeutics
RNA Interference
X-Linked Inhibitor of Apoptosis Protein
50 Citations (Scopus)

Marked anti-tumour activity of the combination of YM155, a novel survivin suppressant, and platinum-based drugs

Iwasa, T., Okamoto, I., Takezawa, K., Yamanaka, K., Nakahara, T., Kita, A., Koutoku, H., Sasamata, M., Hatashita, E., Yamada, Y., Kuwata, K., Fukuoka, M. & Nakagawa, K., Jun 29 2010, In : British journal of cancer. 103, 1, p. 36-42 7 p.

Research output: Contribution to journalArticle

Platinum Compounds
Platinum
Pharmaceutical Preparations
Neoplasms
Heterografts
32 Citations (Scopus)

Phase i clinical and pharmacokinetic study of sorafenib in combination with carboplatin and paclitaxel in patients with advanced non-small cell lung cancer

Okamoto, I., Miyazaki, M., Morinaga, R., Kaneda, H., Ueda, S., Hasegawa, Y., Satoh, T., Kawada, A., Fukuoka, M., Fukino, K., Tanigawa, T. & Nakagawa, K., Dec 1 2010, In : Investigational New Drugs. 28, 6, p. 844-853 10 p.

Research output: Contribution to journalArticle

Carboplatin
Paclitaxel
Non-Small Cell Lung Carcinoma
Pharmacokinetics
Area Under Curve
14 Citations (Scopus)

Phase I clinical and pharmacokinetic study of the glucose-conjugated cytotoxic agent d-19575 (glufosfamide) in patients with solid tumors

Shimizu, T., Okamoto, I., Tamura, K., Satoh, T., Miyazaki, M., Akashi, Y., Ozaki, T., Fukuoka, M. & Nakagawa, K., Jan 1 2010, In : Cancer Chemotherapy and Pharmacology. 65, 2, p. 243-250 8 p.

Research output: Contribution to journalArticle

Ifosfamide
Pharmacokinetics
Cytotoxins
gemcitabine
Toxicity
116 Citations (Scopus)

Phase III trial comparing oral S-1 plus carboplatin with paclitaxel plus carboplatin in chemotherapy-naïve patients with advanced non-small-cell lung cancer: Results of a west Japan oncology group study

Okamoto, I., Yoshioka, H., Morita, S., Ando, M., Takeda, K., Seto, T., Yamamoto, N., Saka, H., Asami, K., Hirashima, T., Kudoh, S., Satouchi, M., Ikeda, N., Iwamoto, Y., Sawa, T., Miyazaki, M., Tamura, K., Kurata, T., Fukuoka, M. & Nakagawa, K., Dec 20 2010, In : Journal of Clinical Oncology. 28, 36, p. 5240-5246 7 p.

Research output: Contribution to journalArticle

Carboplatin
Paclitaxel
Non-Small Cell Lung Carcinoma
Japan
Drug Therapy
14 Citations (Scopus)

Phase II trial of amrubicin for second-line treatment of advanced non-small cell lung cancer: Results of the west japan thoracic oncology group trial (WJTOG0401)

Kaneda, H., Okamoto, I., Hayashi, H., Yoshioka, H., Miyazaki, M., Kudoh, S., Kimura, T., Sugiura, T., Sawa, T., Takeda, K., Iwamoto, Y., Satouchi, M., Akita, K., Saito, H., Goto, I., Shibata, K., Fukuoka, M. & Nakagawa, K., Jan 1 2010, In : Journal of Thoracic Oncology. 5, 1, p. 105-109 5 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Japan
Thorax
Febrile Neutropenia
Topoisomerase II Inhibitors
84 Citations (Scopus)

Phase I safety, pharmacokinetic, and biomarker study of BIBF 1120, an oral triple tyrosine kinase inhibitor in patients with advanced solid tumors

Okamoto, I., Kaneda, H., Satoh, T., Okamoto, W., Miyazaki, M., Morinaga, R., Ueda, S., Terashima, M., Tsuya, A., Sarashina, A., Konishi, K., Arao, T., Nishio, K., Kaiser, R. & Nakagawa, K., Oct 1 2010, In : Molecular Cancer Therapeutics. 9, 10, p. 2825-2833 9 p.

Research output: Contribution to journalArticle

Protein-Tyrosine Kinases
Pharmacokinetics
Biomarkers
Safety
Neoplasms
150 Citations (Scopus)

Randomized phase III trial of platinum-doublet chemotherapy followed by gefitinib compared with continued platinum-doublet chemotherapy in Japanese patients with advanced non-small-cell lung cancer: Results of a West Japan Thoracic Oncology Group Trial (WJTOG0203)

Takeda, K., Hida, T., Sato, T., Ando, M., Seto, T., Satouchi, M., Ichinose, Y., Katakami, N., Yamamoto, N., Kudoh, S., Sasaki, J., Matsui, K., Takayama, K., Kashii, T., Iwamoto, Y., Sawa, T., Okamoto, I., Kurata, T., Nakagawa, K. & Fukuoka, M., Feb 10 2010, In : Journal of Clinical Oncology. 28, 5, p. 753-760 8 p.

Research output: Contribution to journalArticle

Platinum
Non-Small Cell Lung Carcinoma
Japan
Thorax
Drug Therapy