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Research Output 1998 2019

2010
14 Citations (Scopus)

Phase II trial of amrubicin for second-line treatment of advanced non-small cell lung cancer: Results of the west japan thoracic oncology group trial (WJTOG0401)

Kaneda, H., Okamoto, I., Hayashi, H., Yoshioka, H., Miyazaki, M., Kudoh, S., Kimura, T., Sugiura, T., Sawa, T., Takeda, K., Iwamoto, Y., Satouchi, M., Akita, K., Saito, H., Goto, I., Shibata, K., Fukuoka, M. & Nakagawa, K., Jan 1 2010, In : Journal of Thoracic Oncology. 5, 1, p. 105-109 5 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Japan
Thorax
Febrile Neutropenia
Topoisomerase II Inhibitors
85 Citations (Scopus)

Phase I safety, pharmacokinetic, and biomarker study of BIBF 1120, an oral triple tyrosine kinase inhibitor in patients with advanced solid tumors

Okamoto, I., Kaneda, H., Satoh, T., Okamoto, W., Miyazaki, M., Morinaga, R., Ueda, S., Terashima, M., Tsuya, A., Sarashina, A., Konishi, K., Arao, T., Nishio, K., Kaiser, R. & Nakagawa, K., Oct 1 2010, In : Molecular Cancer Therapeutics. 9, 10, p. 2825-2833 9 p.

Research output: Contribution to journalArticle

Protein-Tyrosine Kinases
Pharmacokinetics
Biomarkers
Safety
Neoplasms
150 Citations (Scopus)

Randomized phase III trial of platinum-doublet chemotherapy followed by gefitinib compared with continued platinum-doublet chemotherapy in Japanese patients with advanced non-small-cell lung cancer: Results of a West Japan Thoracic Oncology Group Trial (WJTOG0203)

Takeda, K., Hida, T., Sato, T., Ando, M., Seto, T., Satouchi, M., Ichinose, Y., Katakami, N., Yamamoto, N., Kudoh, S., Sasaki, J., Matsui, K., Takayama, K., Kashii, T., Iwamoto, Y., Sawa, T., Okamoto, I., Kurata, T., Nakagawa, K. & Fukuoka, M., Feb 10 2010, In : Journal of Clinical Oncology. 28, 5, p. 753-760 8 p.

Research output: Contribution to journalArticle

Platinum
Non-Small Cell Lung Carcinoma
Japan
Thorax
Drug Therapy
10 Citations (Scopus)

Retreatment of recurrent malignant pleural mesothelioma with cisplatin and pemetrexed

Hayashi, H., Okamoto, I., Ichikawa, Y., Miyazaki, M., Yoshioka, H., Kunimasa, K. & Nakagawa, K., Oct 1 2010, In : International Journal of Clinical Oncology. 15, 5, p. 497-499 3 p.

Research output: Contribution to journalArticle

Pemetrexed
Retreatment
Cisplatin
Drug Therapy
Drug Combinations
59 Citations (Scopus)

Role of survivin in EGFR inhibitor-induced apoptosis in non-small cell lung cancers positive for EGFR mutations

Okamoto, K., Okamoto, I., Okamoto, W., Tanaka, K., Takezawa, K., Kuwata, K., Yamaguchi, H., Nishio, K. & Nakagawa, K., Dec 15 2010, In : Cancer Research. 70, 24, p. 10402-10410 9 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Apoptosis
Mutation
Epidermal Growth Factor Receptor
Protein-Tyrosine Kinases
21 Citations (Scopus)

Successful treatment with erlotinib after gefitinib-induced severe interstitial lung disease

Takeda, M., Okamoto, I., Makimura, C., Fukuoka, M. & Nakagawa, K., Jan 1 2010, In : Journal of Thoracic Oncology. 5, 7, p. 1103-1104 2 p.

Research output: Contribution to journalArticle

Antineoplastic Combined Chemotherapy Protocols
Quinazolines
X Ray Computed Tomography
Interstitial Lung Diseases
Lung Neoplasms
26 Citations (Scopus)

Successful treatment with erlotinib after gefitinib-related severe hepatotoxicity

Takeda, M., Okamoto, I., Fukuoka, M. & Nakagawa, K., Jun 10 2010, In : Journal of Clinical Oncology. 28, 17, p. e273-e274

Research output: Contribution to journalArticle

Quinazolines
Chemical and Drug Induced Liver Injury
Liver Neoplasms
Non-Small Cell Lung Carcinoma
Antineoplastic Agents
38 Citations (Scopus)

Synergistic antitumor effect of S-1 and HER2-targeting agents in gastric cancer with HER2 amplification

Tanizaki, J., Okamoto, I., Takezawa, K., Tsukioka, S., Uchida, J., Kiniwa, M., Fukuoka, M. & Nakagawa, K., May 1 2010, In : Molecular Cancer Therapeutics. 9, 5, p. 1198-1207 10 p.

Research output: Contribution to journalArticle

Stomach Neoplasms
Fluorouracil
Thymidylate Synthase
human ERBB2 protein
Down-Regulation
61 Citations (Scopus)

TAK-701, a humanized monoclonal antibody to hepatocyte growth factor, reverses gefitinib resistance induced by tumor-derived HGF in non-small cell lung cancer with an EGFR mutation

Okamoto, W., Okamoto, I., Tanaka, K., Hatashita, E., Yamada, Y., Kuwata, K., Yamaguchi, H., Arao, T., Nishio, K., Fukuoka, M., Jänne, P. A. & Nakagawa, K., Oct 1 2010, In : Molecular Cancer Therapeutics. 9, 10, p. 2785-2792 8 p.

Research output: Contribution to journalArticle

Antibodies, Monoclonal, Humanized
Hepatocyte Growth Factor
Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
Mutation
20 Citations (Scopus)
Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
Protein-Tyrosine Kinases
Mutation
Therapeutics
2009
48 Citations (Scopus)

Addition of S-1 to the epidermal growth factor receptor inhibitor gefitinib overcomes gefitinib resistance in non-small cell lung cancer cell lines with MET amplification

Okabe, T., Okamoto, I., Tsukioka, S., Uchida, J., Hatashita, E., Yamada, Y., Yoshida, T., Nishio, K., Fukuoka, M., Jänne, P. A. & Nakagawa, K., Feb 1 2009, In : Clinical Cancer Research. 15, 3, p. 907-913 7 p.

Research output: Contribution to journalArticle

Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
Cell Line
Thymidylate Synthase
Mutation

Cancer of unknown primary site - Current status and future direction

Ichikawa, Y., Okamoto, I. & Nakagawa, K., 2009, In : Japanese Journal of Cancer and Chemotherapy. 36, 6, p. 907-909 3 p.

Research output: Contribution to journalArticle

Neoplasms
Diagnostic Imaging
Physical Examination
Biopsy
Drug Therapy
5 Citations (Scopus)

Cisplatin and etoposide chemotherapy combined with early concurrent twice-daily thoracic radiotherapy for limited-disease small cell lung cancer in elderly patients

Okamoto, K., Okamoto, I., Takezawa, K., Tachibana, I., Fukuoka, M., Nishimura, Y. & Nakagawa, K., Oct 16 2009, In : Japanese Journal of Clinical Oncology. 40, 1, p. 54-59 6 p., hyp137.

Research output: Contribution to journalArticle

Small Cell Lung Carcinoma
Etoposide
Cisplatin
Radiotherapy
Thorax
168 Citations (Scopus)

Combined survival analysis of prospective clinical trials of gefitinib for non-small cell lung cancer with EGFR mutations

Morita, S., Okamoto, I., Kobayashi, K., Yamazaki, K., Asahina, H., Inoue, A., Hagiwara, K., Sunaga, N., Yanagitani, N., Hida, T., Yoshida, K., Hirashima, T., Yasumoto, K., Sugio, K., Mitsudomi, T., Fukuoka, M. & Nukiwa, T., Jul 1 2009, In : Clinical Cancer Research. 15, 13, p. 4493-4498 6 p.

Research output: Contribution to journalArticle

Survival Analysis
Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
Clinical Trials
Mutation
3 Citations (Scopus)

Disturbance of the growth hormone-insulin-like growth factor-1 axis associated with poor performance status in patients with solid tumors

Okamoto, I., Munakata, M., Miyazaki, M., Satoh, T., Takahata, T., Takamatsu, Y., Muto, O., Koike, K., Ishitani, K., Mukaiyama, T., Sakata, Y., Nakagawa, K. & Tamura, K., Nov 25 2009, In : Japanese journal of clinical oncology. 40, 3, p. 222-226 5 p., hyp155.

Research output: Contribution to journalArticle

Somatomedins
Growth Hormone
Neoplasms
Hormones
Insulin-Like Growth Factor Binding Protein 3
50 Citations (Scopus)

Inhibition of insulin-like growth factor 1 receptor by CP-751,871 radiosensitizes non-small cell lung cancer cells

Iwasa, T., Okamoto, I., Suzuki, M., Hatashita, E., Yamada, Y., Fukuoka, M., Ono, K. & Nakagawa, K., Aug 15 2009, In : Clinical Cancer Research. 15, 16, p. 5117-5125 9 p.

Research output: Contribution to journalArticle

Somatomedin Receptors
Non-Small Cell Lung Carcinoma
Radiation
Heterografts
Histones
15 Citations (Scopus)

Phase I/II study of S-1 plus carboplatin in patients with advanced non-small cell lung cancer

Tamura, K., Okamoto, I., Ozaki, T., Kashii, T., Takeda, K., Kobayashi, M., Matsui, K., Shibata, T., Kurata, T., Nakagawa, K. & Fukuoka, M., Aug 1 2009, In : European Journal of Cancer. 45, 12, p. 2132-2137 6 p.

Research output: Contribution to journalArticle

Carboplatin
Non-Small Cell Lung Carcinoma
Survival
Disease-Free Survival
Anemia
58 Citations (Scopus)

Phase I clinical and pharmacokinetic study of Rad001 (everolimus) administered daily to Japanese patients with advanced solid tumors

Okamoto, I., Doi, T., Ohtsu, A., Miyazaki, M., Tsuya, A., Kurei, K., Kobayashi, K. & Nakagawa, K., Sep 25 2009, In : Japanese journal of clinical oncology. 40, 1, p. 17-23 7 p., hyp120.

Research output: Contribution to journalArticle

Pharmacokinetics
Neoplasms
Esophageal Neoplasms
Safety
Stomach Neoplasms
124 Citations (Scopus)

Phase I study of YM155, a novel survivin suppressant, in patients with advanced solid tumors

Satoh, T., Okamoto, I., Miyazaki, M., Morinaga, R., Tsuya, A., Hasegawa, Y., Terashima, M., Ueda, S., Fukuoka, M., Ariyoshi, Y., Saito, T., Masuda, N., Watanabe, H., Taguchi, T., Kakihara, T., Aoyama, Y., Hashimoto, Y. & Nakagawa, K., Jun 1 2009, In : Clinical Cancer Research. 15, 11, p. 3872-3880 9 p.

Research output: Contribution to journalArticle

Maximum Tolerated Dose
Neoplasms
Pharmacokinetics
Inhibitor of Apoptosis Proteins
Safety
21 Citations (Scopus)

S-1: A new oral fluoropyrimidine in the treatment of patients with advanced non-small-cell lung cancer

Okamoto, I. & Fukuoka, M., Jan 1 2009, In : Clinical Lung Cancer. 10, 4, p. 290-294 5 p.

Research output: Contribution to journalReview article

Non-Small Cell Lung Carcinoma
irinotecan
gemcitabine
Platinum Compounds
Tegafur
61 Citations (Scopus)

Sorafenib inhibits non-small cell lung cancer cell growth by targeting B-RAF in KRAS wild-type cells and C-RAF in KRAS mutant cells

Takezawa, K., Okamoto, I., Yonesaka, K., Hatashita, E., Yamada, Y., Fukuoka, M. & Nakagawa, K., Aug 15 2009, In : Cancer Research. 69, 16, p. 6515-6521 7 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Growth
Extracellular Signal-Regulated MAP Kinases
Phosphorylation
sorafenib
58 Citations (Scopus)

SRPX2 is overexpressed in gastric cancer and promotes cellular migration and adhesion

Tamaka, K., Aran, T., Maegawa, M., Matsumoto, K., Kaneda, H., Kudo, K., Fujita, Y., Yokote, H., Yanagihara, K., Yamada, Y., Okamoto, I., Nakagawa, K. & Nishio, K., Mar 1 2009, In : International Journal of Cancer. 124, 5, p. 1072-1080 9 p.

Research output: Contribution to journalArticle

Stomach Neoplasms
Proteins
Focal Adhesion Protein-Tyrosine Kinases
HEK293 Cells
Gene Fusion

The role to be played by the specialty of tumor chemotherapy: a discussion

Eguchi, K., Tamura, K., Okamoto, I., Munakata, W. & Imamura, T., Aug 10 2009, In : Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine. 98, 8, p. 1959-1975 17 p.

Research output: Contribution to journalArticle

Palliative Care
Medicine
Drug Therapy
Neoplasms
3 Citations (Scopus)

Zoledronic acid-induced regression of multiple metastases at nonskeletal sites

Okamoto, K., Tsurutani, J., Terashima, M., Okamoto, I. & Nakagawa, K., Apr 7 2009, In : Annals of Oncology. 20, 4, p. 796-797 2 p.

Research output: Contribution to journalArticle

2008
43 Citations (Scopus)

A phase II trial of gefitinib monotherapy in Chemotherapy-Naïve patients of 75 years or older with advanced non-small cell lung cancer

Ebi, N., Semba, H., Tokunaga, S., Takayama, K., Wataya, H., Kuraki, T., Yamamoto, H., Akamine, S. J. I., Okamoto, I. & Nakanishi, Y., Jan 1 2008, In : Journal of Thoracic Oncology. 3, 10, p. 1166-1171 6 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Drug Therapy
Epidermal Growth Factor Receptor
gefitinib
Mutation
29 Citations (Scopus)

Association of epidermal growth factor receptor (EGFR) gene mutations with EGFR amplification in advanced non-small cell lung cancer

Morinaga, R., Okamoto, I., Fujita, Y., Arao, T., Sekijima, M., Nishio, K., Ito, H., Fukuoka, M., Kadota, J. I. & Nakagawa, K., Dec 12 2008, In : Cancer Science. 99, 12, p. 2455-2460 6 p.

Research output: Contribution to journalArticle

erbB-1 Genes
Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
Mutation
Scorpions
81 Citations (Scopus)

Enhancement of the antitumor activity of ionising radiation by nimotuzumab, a humanised monoclonal antibody to the epidermal growth factor receptor, in non-small cell lung cancer cell lines of differing epidermal growth factor receptor status

Akashi, Y., Okamoto, I., Iwasa, T., Yoshida, T., Suzuki, M., Hatashita, E., Yamada, Y., Satoh, T., Fukuoka, M., Ono, K. & Nakagawa, K., Feb 26 2008, In : British journal of cancer. 98, 4, p. 749-755 7 p.

Research output: Contribution to journalArticle

Antibodies, Monoclonal, Humanized
Ionizing Radiation
Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
Cell Line
10 Citations (Scopus)

Large cell neuroendocrine carcinoma of the mediastinum with α-fetoprotein production

Takezawa, K., Okamoto, I., Fukuoka, J., Tanaka, K., Kaneda, H., Uejima, H., Yoon, H. E., Imakita, M., Fukuoka, M. & Nakagawa, K., Jan 1 2008, In : Journal of Thoracic Oncology. 3, 2, p. 187-189 3 p.

Research output: Contribution to journalArticle

Fetal Proteins
Neuroendocrine Carcinoma
Large Cell Carcinoma
Mediastinum
Lung
40 Citations (Scopus)

Matuzumab and cetuximab activate the epidermal growth factor receptor but fail to trigger downstream signaling by Akt or Erk

Yoshida, T., Okamoto, I., Okabe, T., Iwasa, T., Satoh, T., Nishio, K., Fukuoka, M. & Nakagawa, K., Apr 1 2008, In : International Journal of Cancer. 122, 7, p. 1530-1538 9 p.

Research output: Contribution to journalArticle

Epidermal Growth Factor Receptor
Epidermal Growth Factor
Monoclonal Antibodies
Cell Survival
Phosphorylation

Molecular targeting therapy for treatment of non-small-cell lung carcinoma

Okamoto, I., Jan 1 2008, In : Gan to kagaku ryoho. Cancer & chemotherapy. 35, 8, p. 1303-1309 7 p.

Research output: Contribution to journalArticle

Antineoplastic Combined Chemotherapy Protocols
Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
Immunotherapy
Vascular Endothelial Growth Factor A
181 Citations (Scopus)

Multicentre prospective phase II trial of gefitinib for advanced non-small cell lung cancer with epidermal growth factor receptor mutations: Results of the West Japan Thoracic Oncology Group trial (WJTOG0403)

Tamura, K., Okamoto, I., Kashii, T., Negoro, S., Hirashima, T., Kudoh, S., Ichinose, Y., Ebi, N., Shibata, K., Nishimura, T., Katakami, N., Sawa, T., Shimizu, E., Fukuoka, J., Satoh, T. & Fukuoka, M., Mar 11 2008, In : British journal of cancer. 98, 5, p. 907-914 8 p.

Research output: Contribution to journalArticle

Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
Japan
Thorax
Mutation
109 Citations (Scopus)

Mutations in the LKB1 tumour suppressor are frequently detected in tumours from Caucasian but not Asian lung cancer patients

Koivunen, J. P., Kim, J., Lee, J., Rogers, A. M., Park, J. O., Zhao, X., Naoki, K., Okamoto, I., Nakagawa, K., Yeap, B. Y., Meyerson, M., Wong, K. K., Richards, W. G., Sugarbaker, D. J., Johnson, B. E. & Jänne, P. A., Jul 22 2008, In : British journal of cancer. 99, 2, p. 245-252 8 p.

Research output: Contribution to journalArticle

Lung Neoplasms
Mutation
Non-Small Cell Lung Carcinoma
Neoplasms
Squamous Cell Carcinoma
20 Citations (Scopus)
Non-Small Cell Lung Carcinoma
Meta-Analysis
Japan
Radiotherapy
Carboplatin
13 Citations (Scopus)

Pharmacokinetic analysis of carboplatin and etoposide in a small cell lung cancer patient undergoing hemodialysis

Takezawa, K., Okamoto, I., Fukuoka, M. & Nakagawa, K., Jan 1 2008, In : Journal of Thoracic Oncology. 3, 9, p. 1073-1075 3 p.

Research output: Contribution to journalArticle

Carboplatin
Small Cell Lung Carcinoma
Etoposide
Renal Dialysis
Pharmacokinetics
22 Citations (Scopus)

Phase II study of combination therapy with S-1 and irinotecan for advanced non-small cell lung cancer: West japan thoracic oncology group 3505

Okamoto, I., Nishimura, T., Miyazaki, M., Yoshioka, H., Kubo, A., Takeda, K., Ebi, N., Sugawara, S., Katakami, N., Fukuoka, M. & Nakagawa, K., Aug 15 2008, In : Clinical Cancer Research. 14, 16, p. 5250-5254 5 p.

Research output: Contribution to journalArticle

irinotecan
Non-Small Cell Lung Carcinoma
Japan
Thorax
Confidence Intervals
103 Citations (Scopus)

Radiosensitizing effect of YM155, a novel small-molecule survivin suppressant, in non-small cell lung cancer cell lines

Iwasa, T., Okamoto, I., Suzuki, M., Nakahara, T., Yamanaka, K., Hatashita, E., Yamada, Y., Fukuoka, M., Ono, K. & Nakagawa, K., Oct 15 2008, In : Clinical Cancer Research. 14, 20, p. 6496-6504 9 p.

Research output: Contribution to journalArticle

Radiation-Sensitizing Agents
Non-Small Cell Lung Carcinoma
Radiation
Cell Line
Heterografts
63 Citations (Scopus)

Synergistic antitumor effect of S-1 and the epidermal growth factor receptor inhibitor gefitinib in non-small cell lung cancer cell lines: Role of gefitinib-induced down-regulation of thymidylate synthase

Okabe, T., Okamoto, I., Tsukioka, S., Uchida, J., Iwasa, T., Yoshida, T., Hatashita, E., Yamada, Y., Satoh, T., Tamura, K., Fukuoka, M. & Nakagawa, K., Mar 1 2008, In : Molecular Cancer Therapeutics. 7, 3, p. 599-606 8 p.

Research output: Contribution to journalArticle

Thymidylate Synthase
Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
Down-Regulation
Cell Line
13 Citations (Scopus)

The anti-EGFR monoclonal antibody blocks cisplatin-induced activation of EGFR signaling mediated by HB-EGF

Yoshida, T., Okamoto, I., Iwasa, T., Fukuoka, M. & Nakagawa, K., Dec 24 2008, In : FEBS Letters. 582, 30, p. 4125-4130 6 p.

Research output: Contribution to journalArticle

Epidermal Growth Factor Receptor
Epidermal Growth Factor
Cisplatin
Heparin
Intercellular Signaling Peptides and Proteins
2007
21 Citations (Scopus)

Amrubicin for non-small-cell lung cancer and small-cell lung cancer

Kurata, T., Okamoto, I., Tamura, K. & Fukuoka, M., Oct 1 2007, In : Investigational New Drugs. 25, 5, p. 499-504 6 p.

Research output: Contribution to journalReview article

Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma
Cisplatin
Clinical Trials
Topoisomerase II Inhibitors
117 Citations (Scopus)

Differential constitutive activation of the epidermal growth factor receptor in non-small cell lung cancer cells bearing EGFR gene mutation and amplification

Okabe, T., Okamoto, I., Tamura, K., Terashima, M., Yoshida, T., Satoh, T., Takada, M., Fukuoka, M. & Nakagawa, K., Mar 1 2007, In : Cancer Research. 67, 5, p. 2046-2053 8 p.

Research output: Contribution to journalArticle

erbB-1 Genes
Gene Amplification
Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
Mutation
17 Citations (Scopus)

Down-regulation of survivin by ultraviolet C radiation is dependent on p53 and results in G2-M arrest in A549 cells

Ikeda, M., Okamoto, I., Tamura, K., Satoh, T., Yonesaka, K., Fukuoka, M. & Nakagawa, K., Apr 18 2007, In : Cancer Letters. 248, 2, p. 292-298 7 p.

Research output: Contribution to journalArticle

Down-Regulation
Radiation
DNA Damage
RNA Interference
Lung Neoplasms
21 Citations (Scopus)

Oxaliplatin/fluorouracil/leucovorin (FOLFOX4 and modified FOLFOX6) in patients with refractory or advanced colorectal cancer: Post-approval Japanese population experience

Shimizu, T., Satoh, T., Tamura, K., Ozaki, T., Okamoto, I., Fukuoka, M. & Nakagawa, K., Jun 1 2007, In : International Journal of Clinical Oncology. 12, 3, p. 218-223 6 p.

Research output: Contribution to journalArticle

oxaliplatin
Leucovorin
Fluorouracil
Colorectal Neoplasms
Peripheral Nervous System Diseases
3 Citations (Scopus)

Phase I study of combination therapy with S-1 and weekly docetaxel for advanced gastric cancer

Ozaki, T., Tamura, K., Satoh, T., Kurata, T., Shimizu, T., Miyazaki, M., Okamoto, I., Nakagawa, K. & Fukuoka, M., Jul 1 2007, In : Anticancer research. 27, 4 C, p. 2657-2665 9 p.

Research output: Contribution to journalArticle

docetaxel
Stomach Neoplasms
Febrile Neutropenia
Pharmacokinetics
Stomatitis
79 Citations (Scopus)

Sequential occurrence of non-small cell and small cell lung cancer with the same EGFR mutation

Morinaga, R., Okamoto, I., Furuta, K., Kawano, Y., Sekijima, M., Dote, K., Satou, T., Nishio, K., Fukuoka, M. & Nakagawa, K., Dec 1 2007, In : Lung Cancer. 58, 3, p. 411-413 3 p.

Research output: Contribution to journalArticle

Small Cell Lung Carcinoma
Mutation
Non-Small Cell Lung Carcinoma
Exons
18 Citations (Scopus)

The novel microtubule-interfering agent TZT-1027 enhances the anticancer effect of radiation in vitro and in vivo

Akashi, Y., Okamoto, I., Suzuki, M., Tamura, K., Iwasa, T., Hisada, S., Satoh, T., Nakagawa, K., Ono, K. & Fukuoka, M., May 21 2007, In : British journal of cancer. 96, 10, p. 1532-1539 8 p.

Research output: Contribution to journalArticle

Radiation Effects
Microtubules
Radiation
Cell Cycle
Apoptosis
2006
86 Citations (Scopus)

EGFR mutation in gefitinib-responsive small-cell lung cancer [4]

Okamoto, I., Araki, J., Suto, R., Shimada, M., Nakagawa, K. & Fukuoka, M., Jun 1 2006, In : Annals of Oncology. 17, 6, p. 1028-1029 2 p.

Research output: Contribution to journalLetter

Quinazolines
Small Cell Carcinoma
Small Cell Lung Carcinoma
Epidermal Growth Factor Receptor
Antineoplastic Agents
19 Citations (Scopus)

Is the importance of achieving stable disease different between epidermal growth factor receptor tyrosine kinase inhibitors and cytotoxic agents in the second-line setting for advanced non-small cell lung cancer?

Kurata, T., Matsuo, K., Takada, M., Kawahara, M., Tsuji, M., Matsubara, Y., Otani, N., Matsuyama, S., Muraishi, K., Fujita, T., Ishikawa, M., Koyano, K., Okamoto, I., Satoh, T., Tamura, K., Nakagawa, K. & Fukuoka, M., Sep 1 2006, In : Journal of Thoracic Oncology. 1, 7, p. 684-691 8 p.

Research output: Contribution to journalArticle

Cytotoxins
Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
Protein-Tyrosine Kinases
PubMed
10 Citations (Scopus)

Pemetrexed-induced edema of the eyelid

Kurata, T., Tamura, K., Okamoto, I., Satoh, T., Nakagawa, K. & Fukuoka, M., Nov 1 2006, In : Lung Cancer. 54, 2, p. 241-242 2 p.

Research output: Contribution to journalArticle

Pemetrexed
Eyelids
Edema
Antimetabolites
Pamphlets
21 Citations (Scopus)

Pharmacokinetics of amrubicin and its active metabolite amrubicinol in lung cancer patients

Matsunaga, Y., Hamada, A., Okamoto, I., Sasaki, J. I., Moriyama, E., Kishi, H., Matsumoto, M., Hira, A., Watanabe, H. & Saito, H., Feb 1 2006, In : Therapeutic drug monitoring. 28, 1, p. 76-82 7 p.

Research output: Contribution to journalArticle

Lung Neoplasms
Pharmacokinetics
Area Under Curve
amrubicin
amrubicinol
29 Citations (Scopus)

Phase I and pharmacokinetic study of amrubicin, a synthetic 9-aminoanthracycline, in patients with refractory or relapsed lung cancer.

Okamoto, I., Hamada, A., Matsunaga, Y., Sasaki, J. I., Fujii, S., Uramoto, H., Yamagata, H., Mori, I., Kishi, H., Semba, H. & Saito, H., Jan 1 2006, In : Cancer chemotherapy and pharmacology. 57, 3, p. 282-288 7 p.

Research output: Contribution to journalArticle

Pharmacokinetics
Refractory materials
Lung Neoplasms
Area Under Curve
Maximum Tolerated Dose