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Research Output 1998 2019

2006
263 Citations (Scopus)

Predictive factors for interstitial lung disease, antitumor response, and survival in non-small-cell lung cancer patients treated with gefitinib

Ando, M., Okamoto, I., Yamamoto, N., Takeda, K., Tamura, K., Seto, T., Ariyoshi, Y. & Fukuoka, M., Jun 1 2006, In : Journal of Clinical Oncology. 24, 16, p. 2549-2556 8 p.

Research output: Contribution to journalArticle

Interstitial Lung Diseases
Non-Small Cell Lung Carcinoma
Survival
Smoking
Histology
2005
37 Citations (Scopus)

Efficacy of the tyrosine kinase inhibitor gefitinib in a patient with metastatic small cell lung cancer

Araki, J., Okamoto, I., Suto, R., Ichikawa, Y. & Sasaki, J. I., Jan 1 2005, In : Lung Cancer. 48, 1, p. 141-144 4 p.

Research output: Contribution to journalArticle

Small Cell Lung Carcinoma
Protein-Tyrosine Kinases
Therapeutics
gefitinib
Epidermal Growth Factor Receptor
19 Citations (Scopus)

Phase II study of carboplatin-paclitaxel combination chemotherapy in elderly patients with advanced non-small cell lung cancer

Okamoto, I., Moriyama, E., Fujii, S., Kishi, H., Nomura, M., Goto, E., Kiyofuji, C., Imamura, F., Mori, T. & Matsumoto, M., Apr 1 2005, In : Japanese journal of clinical oncology. 35, 4, p. 188-194 7 p.

Research output: Contribution to journalArticle

Carboplatin
Paclitaxel
Combination Drug Therapy
Non-Small Cell Lung Carcinoma
Myalgia
2004
86 Citations (Scopus)

Deregulation and Mislocalization of the Cytokinesis Regulator ECT2 Activate the Rho Signaling Pathways Leading to Malignant Transformation

Saito, S., Liu, X. F., Kamijo, K., Raziuddin, R., Tatsumoto, T., Okamoto, I., Chen, X., Lee, C. C., Lorenzi, M. V., Ohara, N. & Miki, T., Feb 20 2004, In : Journal of Biological Chemistry. 279, 8, p. 7169-7179 11 p.

Research output: Contribution to journalArticle

rho GTP-Binding Proteins
Cytokinesis
Deregulation
Nuclear Localization Signals
Guanine Nucleotide Exchange Factors
6 Citations (Scopus)

Treatment of a primary pulmonary angiosarcoma [7] (multiple letters)

Duck, L., Baurain, J. F., Machiels, J. P., Kojima, K., Okamoto, I., Ushijima, S. & Yoshinaga, T., Jan 1 2004, In : Chest. 126, 1, p. 317-318 2 p.

Research output: Contribution to journalLetter

Hemangiosarcoma
Lung
2003
9 Citations (Scopus)

Absence of gallium uptake in unicentric and multicentric Castleman's disease

Okamoto, I., Iyonaga, K., Fujii, K., Mori, T., Yoshioka, M., Kohrogi, H., Matsumoto, M. & Suga, M., Aug 1 2003, In : Internal Medicine. 42, 8, p. 735-739 5 p.

Research output: Contribution to journalArticle

Giant Lymph Node Hyperplasia
Gallium
Lymphoproliferative Disorders
Radionuclide Imaging
Mediastinum
86 Citations (Scopus)

Constitutively active forms of c-Jun NH2-terminal kinase are expressed in primary glial tumors

Tsuiki, H., Tnani, M., Okamoto, I., Kenyon, L. C., Emlet, D. R., Holgado-Madruga, M., Lanham, I. S., Joynes, C. J., Vo, K. T. & Wong, A. J., Jan 1 2003, In : Cancer Research. 63, 1, p. 250-255 6 p.

Research output: Contribution to journalArticle

JNK Mitogen-Activated Protein Kinases
Neuroglia
Protein Isoforms
Neoplasms
Phosphotransferases
57 Citations (Scopus)

Diffuse alveolar damage after ZD1839 therapy in a patient with non-small cell lung cancer

Okamoto, I., Fujii, K., Matsumoto, M., Terasaki, Y., Kihara, N., Kohrogi, H. & Suga, M., Jun 1 2003, In : Lung Cancer. 40, 3, p. 339-342 4 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Therapeutics
Lung
X Ray Computed Tomography
Epidermal Growth Factor Receptor
110 Citations (Scopus)

Expression of constitutively activated EGFRvIII in non-small cell lung cancer

Okamoto, I., Kenyon, L. C., Emlet, D. R., Mori, T., Sasaki, J. I., Hirosako, S., Ichikawa, Y., Kishi, H., Godwin, A. K., Yoshioka, M., Suga, M., Matsumoto, M. & Wong, A. J., Jan 1 2003, In : Cancer Science. 94, 1, p. 50-56 7 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Epidermal Growth Factor Receptor
Lung
Neoplasms
epidermal growth factor receptor VIII
109 Citations (Scopus)

Presenilin-dependent γ-secretase activity mediates the intramembranous cleavage of CD44

Murakami, D., Okamoto, I., Nagano, O., Kawano, Y., Tomita, T., Iwatsubo, T., De Strooper, B., Yumoto, E. & Saya, H., Mar 13 2003, In : Oncogene. 22, 10, p. 1511-1516 6 p.

Research output: Contribution to journalArticle

Presenilins
Amyloid Precursor Protein Secretases
Tetradecanoylphorbol Acetate
Signal Transduction
Physiological Phenomena
3 Citations (Scopus)

Pulmonary toxicity due to chemotherapy. How is the risk and benefit from ZD1839 treatment against non-small cell lung cancer?

Okamoto, I. & Suga, M., Jan 1 2003, In : Internal Medicine. 42, 10, p. 926-927 2 p.

Research output: Contribution to journalEditorial

gemcitabine
Quinazolines
Non-Small Cell Lung Carcinoma
Antineoplastic Agents
Lung Diseases
42 Citations (Scopus)

Successful Treatment of Primary Pulmonary Angiosarcoma

Kojima, K., Okamoto, I., Ushijima, S., Yoshinaga, T., Kitaoka, M., Suga, M. & Sasaki, Y., Jan 1 2003, In : Chest. 124, 6, p. 2397-2400 4 p.

Research output: Contribution to journalArticle

Hemangiosarcoma
Lung
Therapeutics
Immunotherapy
Interleukin-2
2002
86 Citations (Scopus)

Elevated JNK activation contributes to the pathogenesis of human brain tumors

Antonyak, M. A., Kenyon, L. C., Godwin, A. K., James, D. C., Emlet, D. R., Okamoto, I., Tnani, M., Holgado-Madruga, M., Moscatello, D. K. & Wong, A. J., Aug 1 2002, In : Oncogene. 21, 33, p. 5038-5046 9 p.

Research output: Contribution to journalArticle

Brain Neoplasms
Tumor Cell Line
MAP Kinase Signaling System
Epidermal Growth Factor Receptor
Epidermal Growth Factor
121 Citations (Scopus)

Proteolytic cleavage of the CD44 adhesion molecule in multiple human tumors

Okamoto, I., Tsuiki, H., Kenyon, L. C., Godwin, A. K., Emlet, D. R., Holgado-Madruga, M., Lanham, I. S., Joynes, C. J., Vo, K. T., Guha, A., Matsumoto, M., Ushio, Y., Saya, H. & Wong, A. J., Jan 1 2002, In : American Journal of Pathology. 160, 2, p. 441-447 7 p.

Research output: Contribution to journalArticle

Neoplasms
Anti-Idiotypic Antibodies
Carcinoma
Membranes
Cell Adhesion Molecules
2001
266 Citations (Scopus)

Proteolytic release of CD44 intracellular domain and its role in the CD44 signaling pathway

Okamoto, I., Kawano, Y., Murakami, D., Sasayama, T., Araki, N., Miki, T., Wong, A. J. & Saya, H., Nov 26 2001, In : Journal of Cell Biology. 155, 5, p. 755-762 8 p.

Research output: Contribution to journalArticle

Transcriptional Activation
Cell Adhesion Molecules
p300-CBP Transcription Factors
Biological Phenomena
Metalloproteases
2000
56 Citations (Scopus)

Ras oncoprotein induces CD44 cleavage through phosphoinositide 3-OH kinase and the Rho family of small G proteins

Kawano, Y., Okamoto, I., Murakami, D., Itoh, H., Yoshida, M., Ueda, S. & Saya, H., Sep 22 2000, In : Journal of Biological Chemistry. 275, 38, p. 29628-29635 8 p.

Research output: Contribution to journalArticle

Monomeric GTP-Binding Proteins
Oncogene Proteins
Phosphatidylinositols
Phosphotransferases
Cells
1999
102 Citations (Scopus)

Calcium influx triggers the sequential proteolysis of extracellular and cytoplasmic domains of E-cadherin, leading to loss of β-catenin from cell-cell contacts

Ito, K., Okamoto, I., Araki, N., Kawano, Y., Nakao, M., Fujiyama, S., Tomita, K., Mimori, T. & Saya, H., Nov 25 1999, In : Oncogene. 18, 50, p. 7080-7090 11 p.

Research output: Contribution to journalArticle

Catenins
Cadherins
Proteolysis
Calcium
Metalloproteases
189 Citations (Scopus)

CD44 cleavage induced by a membrane-associated metalloprotease plays a critical role in tumor cell migration

Okamoto, I., Kawano, Y., Tsuiki, H., Sasaki, J. I., Nakao, M., Matsumoto, M., Suga, M., Ando, M., Nakajima, M. & Saya, H., Feb 18 1999, In : Oncogene. 18, 7, p. 1435-1446 12 p.

Research output: Contribution to journalArticle

Metalloproteases
Cell Movement
Membranes
Neoplasms
Extracellular Matrix
301 Citations (Scopus)

Human ECT2 is an exchange factor for Rho GTPases, phosphorylated in G2/M phases, and involved in cytokinesis

Tatsumoto, T., Xie, X., Blumenthal, R., Okamoto, I. & Miki, T., Nov 29 1999, In : Journal of Cell Biology. 147, 5, p. 921-927 7 p.

Research output: Contribution to journalArticle

rho GTP-Binding Proteins
Cytokinesis
G2 Phase
Cell Division
Interphase
84 Citations (Scopus)

Regulated CD44 cleavage under the control of protein kinase C, calcium influx, and the rho family of small G proteins

Okamoto, I., Kawano, Y., Matsumoto, M., Suga, M., Kaibuchi, K., Ando, M. & Saya, H., Sep 3 1999, In : Journal of Biological Chemistry. 274, 36, p. 25525-25534 10 p.

Research output: Contribution to journalArticle

Monomeric GTP-Binding Proteins
Tetradecanoylphorbol Acetate
Protein Kinase C
Acetates
Cells
1998
15 Citations (Scopus)

Expression of CD44 splicing isoforms in lung cancers: Dominant expression of CD44v8-10 in non-small cell lung carcinomas

Sasaki, J. I. I., Tanabe, K. K., Takahashi, K., Okamoto, I., Fujimoto, H., Matsumoto, M., Suga, M., Ando, M. & Saya, H., Mar 1 1998, In : International journal of oncology. 12, 3, p. 525-533 9 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Lung Neoplasms
Protein Isoforms
Lung
Small Cell Lung Carcinoma
19 Citations (Scopus)

Highly specific and sensitive detection of malignancy in urine samples from patients with urothelial cancer by CD44v8-10/CD44v10 competitive RT-PCR

Miyake, H., Okamoto, I., Hiara, I., Gohji, K., Yamanaka, K., Arakawa, S., Kamidono, S. & Saya, H., Dec 14 1998, In : International Journal of Cancer. 79, 6, p. 560-564 5 p.

Research output: Contribution to journalArticle

Urine
Polymerase Chain Reaction
Neoplasms
Reverse Transcription
Protein Isoforms
31 Citations (Scopus)

Interaction between CD44 and hyaluronic acid regulates human prostate cancer development

Miyake, H., Hara, I., Okamoto, I., Gohji, K., Yamanaka, K., Arakawa, S., Saya, H. & Kamidono, S., Jan 1 1998, In : Journal of Urology. 160, 4, p. 1562-1566 5 p.

Research output: Contribution to journalArticle

Hyaluronic Acid
Prostatic Neoplasms
Protein Isoforms
Aptitude
Human Development
53 Citations (Scopus)

Molecular detection of cancer cells by competitive reverse transcription-polymerase chain reaction analysis of specific CD44 variant RNAs

Okamoto, I., Morisaki, T., Sasaki, J. I., Miyake, H., Matsumoto, M., Suga, M., Ando, M. & Saya, H., Feb 18 1998, In : Journal of the National Cancer Institute. 90, 4, p. 307-315 9 p.

Research output: Contribution to journalArticle

Reverse Transcription
RNA
Polymerase Chain Reaction
Messenger RNA
Pleural Effusion