If you made any changes in Pure these will be visible here soon.

Research Output 1998 2019

Filter
Article
2016
36 Citations (Scopus)

Anti-HER3 monoclonal antibody patritumab sensitizes refractory non-small cell lung cancer to the epidermal growth factor receptor inhibitor erlotinib

Yonesaka, K., Hirotani, K., Kawakami, H., Takeda, M., Kaneda, H., Sakai, K., Okamoto, I., Nishio, K., Jänne, P. A. & Nakagawa, K., Feb 18 2016, In : Oncogene. 35, 7, p. 878-886 9 p.

Research output: Contribution to journalArticle

Neuregulin-1
Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
Monoclonal Antibodies
Protein-Tyrosine Kinases
28 Citations (Scopus)

Bevacizumab beyond disease progression after first-line treatment with bevacizumab plus chemotherapy in advanced nonsquamous non-small cell lung cancer (West Japan Oncology Group 5910L): An open-label, randomized, phase 2 trial

Takeda, M., Yamanaka, T., Seto, T., Hayashi, H., Azuma, K., Okada, M., Sugawara, S., Daga, H., Hirashima, T., Yonesaka, K., Urata, Y., Murakami, H., Saito, H., Kubo, A., Sawa, T., Miyahara, E., Nogami, N., Nakagawa, K., Nakanishi, Y. & Okamoto, I., Apr 1 2016, In : Cancer. 122, 7, p. 1050-1059 10 p.

Research output: Contribution to journalArticle

docetaxel
Non-Small Cell Lung Carcinoma
Disease Progression
Japan
Drug Therapy
24 Citations (Scopus)

Characteristics and overall survival of EGFR mutation-positive non-small cell lung cancer treated with EGFR tyrosine kinase inhibitors: A retrospective analysis for 1660 Japanese patients

Inoue, A., Yoshida, K., Morita, S., Imamura, F., Seto, T., Okamoto, I., Nakagawa, K., Yamamoto, N., Muto, S. & Fukuoka, M., Jan 1 2016, In : Japanese Journal of Clinical Oncology. 46, 5, p. 462-467 6 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Protein-Tyrosine Kinases
Epidermal Growth Factor Receptor
Mutation
Survival
5 Citations (Scopus)

Characteristics of smoking patients with lung cancer with emphysematous bullae

Iwama, E., Okamoto, I., Yabuuchi, H., Takayama, K., Harada, T., Matsuo, Y., Tokunaga, S., Baba, E. & Nakanishi, Y., Jan 1 2016, In : Journal of Thoracic Oncology. 11, 9, p. 1586-1590 5 p.

Research output: Contribution to journalArticle

Blister
Lung Neoplasms
Smoking
Emphysema
Epidermal Growth Factor
63 Citations (Scopus)

Effect of dose adjustment on the safety and efficacy of afatinib for EGFR mutation-positive lung adenocarcinoma: Post hoc analyses of the randomized LUX-Lung 3 and 6 trials

Yang, J. C. H., Sequist, L. V., Zhou, C., Schuler, M., Geater, S. L., Mok, T., Hu, C. P., Yamamoto, N., Feng, J., O'Byrne, K., Lu, S., Hirsh, V., Huang, Y., Sebastian, M., Okamoto, I., Dickgreber, N., Shah, R., Märten, A., Massey, D., Wind, S. & 1 others, Wu, Y. L., Jan 1 2016, In : Annals of Oncology. 27, 11, p. 2103-2110 8 p.

Research output: Contribution to journalArticle

Safety
Lung
Mutation
Disease-Free Survival
Non-Small Cell Lung Carcinoma
11 Citations (Scopus)

FGFR gene alterations in lung squamous cell carcinoma are potential targets for the multikinase inhibitor nintedanib

Hibi, M., Kaneda, H., Tanizaki, J., Sakai, K., Togashi, Y., Terashima, M., De Velasco, M. A., Fujita, Y., Banno, E., Nakamura, Y., Takeda, M., Ito, A., Mitsudomi, T., Nakagawa, K., Okamoto, I. & Nishio, K., Nov 1 2016, In : Cancer Science. 107, 11, p. 1667-1676 10 p.

Research output: Contribution to journalArticle

Fibroblast Growth Factor Receptors
Squamous Cell Carcinoma
Lung
Genes
Cell Line
21 Citations (Scopus)

HER2 genomic amplification in circulating tumor DNA from patients with cetuximab-resistant colorectal cancer

Takegawa, N., Yonesaka, K., Sakai, K., Ueda, H., Watanabe, S., Nonagase, Y., Okuno, T., Takeda, M., Maenishi, O., Tsurutani, J., Satoh, T., Okamoto, I., Nishio, K., Tamura, T. & Nakagawa, K., Jan 1 2016, In : Oncotarget. 7, 3, p. 3453-3460 8 p.

Research output: Contribution to journalArticle

Colorectal Neoplasms
Epidermal Growth Factor Receptor
DNA
Neoplasms
Antibodies
10 Citations (Scopus)

MET-targeted therapy for gastric cancer: the importance of a biomarker-based strategy

Kawakami, H. & Okamoto, I., Jul 1 2016, In : Gastric Cancer. 19, 3, p. 687-695 9 p.

Research output: Contribution to journalArticle

Stomach Neoplasms
Biomarkers
Hepatocyte Growth Factor
Protein-Tyrosine Kinases
Neoplasms
12 Citations (Scopus)

Phase II study of erlotinib plus tivantinib (ARQ 197) in patients with locally advanced or metastatic EGFR mutation-positive non-small-cell lung cancer just after progression on EGFR-TKI, gefitinib or erlotinib

Azuma, K., Hirashima, T., Yamamoto, N., Okamoto, I., Takahashi, T., Nishio, M., Hirata, T., Kubota, K., Kasahara, K., Hida, T., Yoshioka, H., Nakanishi, K., Akinaga, S., Nishio, K., Mitsudomi, T. & Nakagawa, K., Jul 1 2016, In : ESMO Open. 1, 4, e000063.

Research output: Contribution to journalArticle

Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
Mutation
Hepatocyte Growth Factor
Disease-Free Survival
14 Citations (Scopus)

Phase II trial of weekly nab-paclitaxel for previously treated advanced non–small cell lung cancer: Kumamoto thoracic oncology study group (KTOSG) trial 1301

Sakata, S., Saeki, S., Okamoto, I., Otsubo, K., Komiya, K., Morinaga, R., Yoneshima, Y., Koga, Y., Enokizu, A., Kishi, H., Hirosako, S., Yamaguchi, E., Aragane, N., Fujii, S., Harada, T., Iwama, E., Semba, H., Nakanishi, Y. & Kohrogi, H., Sep 1 2016, In : Lung Cancer. 99, p. 41-45 5 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Thorax
docetaxel
Confidence Intervals
Febrile Neutropenia
40 Citations (Scopus)

Re-biopsy status among non-small cell lung cancer patients in Japan: A retrospective study

Nosaki, K., Satouchi, M., Kurata, T., Yoshida, T., Okamoto, I., Katakami, N., Imamura, F., Tanaka, K., Yamane, Y., Yamamoto, N., Kato, T., Kiura, K., Saka, H., Yoshioka, H., Watanabe, K., Mizuno, K. & Seto, T., Nov 1 2016, In : Lung Cancer. 101, p. 1-8 8 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Japan
Retrospective Studies
Biopsy
Epidermal Growth Factor Receptor
2015
47 Citations (Scopus)

Afatinib versus cisplatin plus pemetrexed in Japanese patients with advanced non-small cell lung cancer harboring activating EGFR mutations: Subgroup analysis of LUX-Lung 3

Kato, T., Yoshioka, H., Okamoto, I., Yokoyama, A., Hida, T., Seto, T., Kiura, K., Massey, D., Seki, Y. & Yamamoto, N., Sep 1 2015, In : Cancer Science. 106, 9, p. 1202-1211 10 p.

Research output: Contribution to journalArticle

Pemetrexed
Non-Small Cell Lung Carcinoma
Cisplatin
Lung
Mutation
9 Citations (Scopus)

Circulating hepatocyte growth factor is correlated with resistance to cetuximab in metastatic colorectal cancer

Yonesaka, K., Satoh, T., Ueda, S., Yoshida, T., Takeda, M., Shimizu, T., Okamoto, I., Nishio, K., Tamura, T. & Nakagawa, K., Mar 1 2015, In : Anticancer Research. 35, 3, p. 1683-1690 8 p.

Research output: Contribution to journalArticle

Hepatocyte Growth Factor
Colorectal Neoplasms
Transforming Growth Factors
Epidermal Growth Factor Receptor
Disease-Free Survival
7 Citations (Scopus)
Neuregulin-1
colorectal neoplasms
Colorectal Neoplasms
Plasmas
Epidermal Growth Factor Receptor
7 Citations (Scopus)

Combined analysis of plasma amphiregulin and heregulin predicts response to cetuximab in metastatic colorectal cancer

Yonesaka, K., Takegawa, N., Satoh, T., Ueda, H., Yoshida, T., Takeda, M., Shimizu, T., Chiba, Y., Okamoto, I., Nishio, K., Tamura, T. & Nakagawa, K., Nov 1 2015, In : PloS one. 10, 11, e0143132.

Research output: Contribution to journalArticle

Neuregulin-1
colorectal neoplasms
Colorectal Neoplasms
Plasmas
Epidermal Growth Factor Receptor
40 Citations (Scopus)

Digital PCR analysis of plasma cell-free DNA for non-invasive detection of drug resistance mechanisms in EGFR mutant NSCLC: Correlation with paired tumor samples

Ishii, H., Azuma, K., Sakai, K., Kawahara, A., Yamada, K., Tokito, T., Okamoto, I., Nishio, K. & Hoshino, T., Jan 1 2015, In : Oncotarget. 6, 31, p. 30850-30858 9 p.

Research output: Contribution to journalArticle

Plasma Cells
Epidermal Growth Factor Receptor
Drug Resistance
Non-Small Cell Lung Carcinoma
Polymerase Chain Reaction
20 Citations (Scopus)

Heterogeneity of anaplastic lymphoma kinase gene rearrangement in non-small-cell lung carcinomas: A comparative study between small biopsy and excision samples

Abe, H., Kawahara, A., Azuma, K., Taira, T., Takase, Y., Fukumitsu, C., Murata, K., Yamaguchi, T., Akiba, J., Ishii, H., Okamoto, I., Hoshino, T., Takamori, S. & Kage, M., May 30 2015, In : Journal of Thoracic Oncology. 10, 5, p. 800-805 6 p.

Research output: Contribution to journalArticle

Gene Rearrangement
Non-Small Cell Lung Carcinoma
Fluorescence In Situ Hybridization
Biopsy
Immunohistochemistry
18 Citations (Scopus)

Highly sensitive and quantitative evaluation of the EGFR T790M mutation by nanofluidic digital PCR

Iwama, E., Takayama, K., Harada, T., Okamoto, I., Ookubo, F., Kishimoto, J., Baba, E., Oda, Y. & Nakanishi, Y., Jan 1 2015, In : Oncotarget. 6, 24, p. 20466-20473 8 p.

Research output: Contribution to journalArticle

Polymerase Chain Reaction
Mutation
Alleles
Therapeutics
Neoplasms
9 Citations (Scopus)

Hypermethylation of the CpG dinucleotide in epidermal growth factor receptor codon 790: Implications for a mutational hotspot leading to the T790M mutation in non-small-cell lung cancer

Fujii, A., Harada, T., Iwama, E., ota, K., Furuyama, K., Ijichi, K., Okamoto, T., Okamoto, I., Takayama, K. & Nakanishi, Y., May 1 2015, In : Cancer Genetics. 208, 5, p. 271-278 8 p.

Research output: Contribution to journalArticle

5-Methylcytosine
Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
Codon
Mutation

II. Development and future prospects of the third-generation EGFR-tyrosine kinase inhibitor

Sakata, S., Iwama, E. & Okamoto, I., Aug 1 2015, In : Japanese Journal of Cancer and Chemotherapy. 42, 8, p. 935-939 5 p.

Research output: Contribution to journalArticle

Protein-Tyrosine Kinases

II. Development and Future Prospects of the Third-Generation EGFR-Tyrosine Kinase Inhibitor

Sakata, S., Iwama, E. & Okamoto, I., Aug 1 2015, In : Japanese Journal of Cancer and Chemotherapy. 42, 8, p. 935-939 5 p.

Research output: Contribution to journalArticle

Drug Design
Protein Kinase Inhibitors
Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
Protein-Tyrosine Kinases
200 Citations (Scopus)

Induction of PD-L1 expression by the EML4-ALK oncoprotein and down stream signaling pathways in non-small cell lung cancer

ota, K., Azuma, K., Kawahara, A., Hattori, S., Iwama, E., Tanizaki, J., Harada, T., Matsumoto, K., Takayama, K., Takamori, S., Kage, M., Hoshino, T., Nakanishi, Y. & Okamoto, I., Sep 1 2015, In : Clinical Cancer Research. 21, 17, p. 4014-4021 8 p.

Research output: Contribution to journalArticle

Oncogene Proteins
Non-Small Cell Lung Carcinoma
Gene Fusion
Phosphatidylinositol 3-Kinases
Cell Line
4 Citations (Scopus)

Infected complex renal cysts during crizotinib therapy in a patient with non-small cell lung cancer positive for ALK rearrangement

Yoneshima, Y., Okamoto, I., Arimura-Omori, M., Kimura, S., Hidaka-Fujimoto, N., Iwama, E., Harada, T., Takayama, K. & Nakanishi, Y., Apr 1 2015, In : Investigational New Drugs. 33, 2, p. 510-512 3 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Cysts
Kidney
Therapeutics
Low Back Pain
1 Citation (Scopus)

Multiple regulatory mechanisms of hepatocyte growth factor expression in malignant cells with a short poly(dA) sequence in the HGF gene promoter

Sakai, K., Takeda, M., Okamoto, I., Nakagawa, K. & Nishio, K., Jan 1 2015, In : Oncology Letters. 9, 1, p. 405-410 6 p.

Research output: Contribution to journalArticle

Hepatocyte Growth Factor
Genes
Single Nucleotide Polymorphism
Cell Line
Introns
17 Citations (Scopus)

Nicotine induces resistance to erlotinib via cross-talk between α 1 nAChR and EGFR in the non-small cell lung cancer xenograft model

Li, H., Wang, S., Takayama, K., Harada, T., Okamoto, I., Iwama, E., Fujii, A., ota, K., Hidaka, N., Kawano, Y. & Nakanishi, Y., Apr 1 2015, In : Lung Cancer. 88, 1, p. 1-8 8 p.

Research output: Contribution to journalArticle

Nicotinic Receptors
Nicotine
Heterografts
Non-Small Cell Lung Carcinoma
MAP Kinase Signaling System
14 Citations (Scopus)

Phase i study of amatuximab, a novel monoclonal antibody to mesothelin, in Japanese patients with advanced solid tumors

Fujisaka, Y., Kurata, T., Tanaka, K., Kudo, T., Okamoto, K., Tsurutani, J., Kaneda, H., Okamoto, I., Namiki, M., Kitamura, C. & Nakagawa, K., Apr 1 2015, In : Investigational New Drugs. 33, 2, p. 380-388 9 p.

Research output: Contribution to journalArticle

Monoclonal Antibodies
Maximum Tolerated Dose
Mesothelioma
Neoplasms
Adenocarcinoma
4 Citations (Scopus)

Phase i study of nintedanib in combination with pemetrexed as second-line treatment of Japanese patients with advanced non-small cell lung cancer

Daga, H., Takeda, K., Okada, H., Miyazaki, M., Ueda, S., Kaneda, H., Okamoto, I., Yoh, K., Goto, K., Konishi, K., Sarashina, A., Tanaka, T., Kaiser, R. & Nakagawa, K., Dec 1 2015, In : Cancer chemotherapy and pharmacology. 76, 6, p. 1225-1233 9 p.

Research output: Contribution to journalArticle

Pemetrexed
Non-Small Cell Lung Carcinoma
Cells
Maximum Tolerated Dose
Toxicity
74 Citations (Scopus)

Pooled safety analysis of EGFR-TKI treatment for EGFR mutation-positive non-small cell lung cancer

Takeda, M., Okamoto, I. & Nakagawa, K., Apr 1 2015, In : Lung Cancer. 88, 1, p. 74-79 6 p.

Research output: Contribution to journalArticle

Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
Protein-Tyrosine Kinases
Safety
Mutation
15 Citations (Scopus)

Randomized controlled trial comparing docetaxel-cisplatin combination with weekly docetaxel alone in elderly patients with advanced non-small-cell lung cancer: Japan Clinical Oncology Group (JCOG) 0207

Tsukada, H., Yokoyama, A., Goto, K., Shinkai, T., Harada, M., Ando, M., Shibata, T., Ohe, Y., Tamura, T., Saijo, N., Yamamoto, N., Nishiwaki, Y., Kubota, K., Segawa, Y., Isobe, H., Eguchi, H., Yoneda, S., Sakai, H., Sawa, T., Ishiguro, T. & 24 others, Nakagawa, K., Okamoto, I., Kawahara, M., Atagi, S., Nakano, T., Miyake, M., Kaburaki, T., Fujita, Y., Fujiuchi, S., Kudo, K., Takeda, Y., Hida, T., Senba, H., Fujii, S., Tsukamoto, T., Nagasawa, M., Minato, K., Yoshino, R., Watanabe, K., Kunikane, H., Saito, H., Okuno, M., Ito, M. & Yokota, S., Jan 1 2015, In : Japanese journal of clinical oncology. 45, 1, p. 88-95 8 p., hyu176.

Research output: Contribution to journalArticle

docetaxel
Medical Oncology
Non-Small Cell Lung Carcinoma
Cisplatin
Japan
9 Citations (Scopus)

Severe acute interstitial lung disease in a patient with anaplastic lymphoma kinase rearrangement-positive non-small cell lung cancer treated with alectinib

Yamamoto, Y., Okamoto, I., Otsubo, K., Iwama, E., Hamada, N., Harada, T., Takayama, K. & Nakanishi, Y., Oct 22 2015, In : Investigational New Drugs. 33, 5, p. 1148-1150 3 p.

Research output: Contribution to journalArticle

Interstitial Lung Diseases
Non-Small Cell Lung Carcinoma
Tomography
Lymphocytosis
Bronchoalveolar Lavage Fluid
6 Citations (Scopus)

Successful treatment with alectinib after crizotinib-induced esophageal ulceration

Yoneshima, Y., Okamoto, I., Takano, T., Enokizu, A., Iwama, E., Harada, T., Takayama, K. & Nakanishi, Y., Jun 1 2015, In : Lung Cancer. 88, 3, p. 349-351 3 p.

Research output: Contribution to journalArticle

Therapeutics
Protein-Tyrosine Kinases
crizotinib
CH5424802
Wounds and Injuries
10 Citations (Scopus)

Survival, quality-adjusted survival, and other clinical end points in older advanced non-small-cell lung cancer patients treated with albumin-bound paclitaxel

Langer, C. J., Hirsh, V., Okamoto, I., Lin, F. J., Wan, Y., Whiting, S., Ong, T. J., Renschler, M. F. & Botteman, M. F., Jan 1 2015, In : British journal of cancer. 113, 1, p. 20-29 10 p.

Research output: Contribution to journalArticle

Carboplatin
Non-Small Cell Lung Carcinoma
Paclitaxel
Survival
Quality of Life
48 Citations (Scopus)

The OCT4 pseudogene POU5F1B is amplified and promotes an aggressive phenotype in gastric cancer

Hayashi, H., Arao, T., Togashi, Y., Kato, H., Fujita, Y., De Velasco, M. A., Kimura, H., Matsumoto, K., Tanaka, K., Okamoto, I., Ito, A., Yamada, Y., Nakagawa, K. & Nishio, K., Jan 8 2015, In : Oncogene. 34, 2, p. 199-208 10 p.

Research output: Contribution to journalArticle

Pseudogenes
Stomach Neoplasms
Phenotype
Neoplasms
Cell Line
22 Citations (Scopus)

The pan-HER family tyrosine kinase inhibitor afatinib overcomes HER3 ligand heregulin-mediated resistance to EGFR inhibitors in non-small cell lung cancer

Yonesaka, K., Kudo, K., Nishida, S., Takahama, T., Iwasa, T., Yoshida, T., Tanaka, K., Takeda, M., Kaneda, H., Okamoto, I., Nishio, K. & Nakagawa, K., Jan 1 2015, In : Oncotarget. 6, 32, p. 33602-33611 10 p.

Research output: Contribution to journalArticle

Neuregulin-1
Non-Small Cell Lung Carcinoma
Protein-Tyrosine Kinases
Ligands
Phosphorylation
26 Citations (Scopus)

Tolerability of nintedanib (BIBF 1120) in combination with docetaxel: A phase 1 study in japanese patients with previously treated non-small-cell lung cancer

Okamoto, I., Miyazaki, M., Takeda, M., Terashima, M., Azuma, K., Hayashi, H., Kaneda, H., Kurata, T., Tsurutani, J., Seto, T., Hirai, F., Konishi, K., Sarashina, A., Yagi, N., Kaiser, R. & Nakagawa, K., Feb 6 2015, In : Journal of Thoracic Oncology. 10, 2, p. 346-352 7 p.

Research output: Contribution to journalArticle

docetaxel
Body Surface Area
Non-Small Cell Lung Carcinoma
Maximum Tolerated Dose
nintedanib
2014
29 Citations (Scopus)

Addition of bevacizumab enhances antitumor activity of erlotinib against non-small cell lung cancer xenografts depending on VEGF expression

Li, H., Takayama, K., Wang, S., Shiraishi, Y., Gotanda, K., Harada, T., Furuyama, K., Iwama, E., Ieiri, I., Okamoto, I. & Nakanishi, Y., Oct 9 2014, In : Cancer chemotherapy and pharmacology. 74, 6, p. 1297-1305 9 p.

Research output: Contribution to journalArticle

Heterografts
Non-Small Cell Lung Carcinoma
Vascular Endothelial Growth Factor A
Cells
Tumors
1 Citation (Scopus)

A phase I study of split-dose cisplatin and etoposide with concurrent accelerated hyperfractionated thoracic radiotherapy in elderly patients with limited-disease small cell lung cancer

Okamoto, K., Okamoto, I., Takeda, M., Kobayashi, S., Takeda, K., Nakamatsu, K., Nishimura, Y. & Nakagawa, K., 2014, In : Japanese Journal of Clinical Oncology. 44, 8, p. 743-748 6 p., hyu071.

Research output: Contribution to journalArticle

Small Cell Lung Carcinoma
Etoposide
Cisplatin
Radiotherapy
Thorax
298 Citations (Scopus)

Association of PD-L1 overexpression with activating EGFR mutations in surgically resected nonsmall-cell lung cancer

Azuma, K., ota, K., Kawahara, A., Hattori, S., Iwama, E., Harada, T., Matsumoto, K., Takayama, K., Takamori, S., Kage, M., Hoshino, T., Nakanishi, Y. & Okamoto, I., Oct 1 2014, In : Annals of oncology : official journal of the European Society for Medical Oncology / ESMO. 25, 10, p. 1935-1940 6 p.

Research output: Contribution to journalArticle

erbB-1 Genes
Non-Small Cell Lung Carcinoma
Ligands
Mutation
Cell Line
14 Citations (Scopus)

Bilateral ovarian metastasis of non-small cell lung cancer with ALK rearrangement

Fujiwara, A., Higashiyama, M., Kanou, T., Tokunaga, T., Okami, J., Kodama, K., Nishino, K., Tomita, Y. & Okamoto, I., Feb 1 2014, In : Lung Cancer. 83, 2, p. 302-304 3 p.

Research output: Contribution to journalArticle

Gene Rearrangement
Non-Small Cell Lung Carcinoma
Neoplasm Metastasis
Fluorescence In Situ Hybridization
anaplastic lymphoma kinase
52 Citations (Scopus)

CRIPTO1 expression in EGFR-mutant NSCLC elicits intrinsic EGFR-inhibitor resistance

Park, K. S., Raffeld, M., Moon, Y. W., Xi, L., Bianco, C., Pham, T., Lee, L. C., Mitsudomi, T., Yatabe, Y., Okamoto, I., Subramaniam, D., Mok, T., Rosell, R., Luo, J., Salomon, D. S., Wang, Y. & Giaccone, G., Jul 1 2014, In : Journal of Clinical Investigation. 124, 7, p. 3003-3015 13 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
MicroRNAs
Epithelial-Mesenchymal Transition
Protein-Tyrosine Kinases
Mutation
18 Citations (Scopus)

Cystic brain metastasis in non-small-cell lung cancer with ALK rearrangement

Hayashi, H., Okamoto, I., Tanizaki, J., Tanaka, K., Okuda, T., Kato, A., Nishimura, Y. & Nakagawa, K., Jan 1 2014, In : Journal of Clinical Oncology. 32, 36, p. e122-e124 A31.

Research output: Contribution to journalArticle

Gene Rearrangement
Receptor Protein-Tyrosine Kinases
Non-Small Cell Lung Carcinoma
Brain Neoplasms
Cysts
343 Citations (Scopus)

Erlotinib alone or with bevacizumab as first-line therapy in patients with advanced non-squamous non-small-cell lung cancer harbouring EGFR mutations (JO25567): An open-label, randomised, multicentre, phase 2 study

Seto, T., Kato, T., Nishio, M., Goto, K., Atagi, S., Hosomi, Y., Yamamoto, N., Hida, T., Maemondo, M., Nakagawa, K., Nagase, S., Okamoto, I., Yamanaka, T., Tajima, K., Harada, R., Fukuoka, M. & Yamamoto, N., Oct 1 2014, In : The Lancet Oncology. 15, 11, p. 1236-1244 9 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Mutation
Therapeutics
Disease-Free Survival
Bevacizumab
18 Citations (Scopus)

Multiplex genomic profiling of non-small cell lung cancers from the LETS phase III trial of first-line S-1/carboplatin versus paclitaxel/carboplatin: Results of a West Japan Oncology Group study

Okamoto, I., Sakai, K., Morita, S., Yoshioka, H., Kaneda, H., Takeda, K., Hirashima, T., Kogure, Y., Kimura, T., Takahashi, T., Atagi, S., Seto, T., Sawa, T., Yamamoto, M., Satouchi, M., Okuno, M., Nagase, S., Takayama, K., Tomii, K., Maeda, T. & 8 others, Oizumi, S., Fujii, S., Akashi, Y., Nishino, K., Ebi, N., Nakagawa, K., Nakanishi, Y. & Nishio, K., Jan 1 2014, In : Oncotarget. 5, 8, p. 2293-2304 12 p.

Research output: Contribution to journalArticle

Carboplatin
Paclitaxel
Non-Small Cell Lung Carcinoma
Japan
Mutation
19 Citations (Scopus)

Patient-reported neuropathy and taxane-associated symptoms in a phase 3 trial of nab-paclitaxel plus carboplatin versus solvent-based paclitaxel plus carboplatin for advanced non-small-cell lung cancer

Hirsh, V., Okamoto, I., Hon, J. K., Page, R. D., Orsini, J., Sakai, H., Zhang, H., Renschler, M. F. & Socinski, M. A., Jan 1 2014, In : Journal of Thoracic Oncology. 9, 1, p. 83-90 8 p.

Research output: Contribution to journalArticle

Carboplatin
Paclitaxel
Non-Small Cell Lung Carcinoma
Peripheral Nervous System Diseases
Physicians
3 Citations (Scopus)

Phase II clinical trial of S-1 plus oral leucovorin in previously treated patients with non-small-cell lung cancer

Naito, T., Seto, T., Takeda, K., Goto, K., Okamoto, I., Nakagawa, K., Oba, T., Murakami, H., Takahashi, T., Yamanaka, T. & Yamamoto, N., Dec 1 2014, In : Lung Cancer. 86, 3, p. 339-343 5 p.

Research output: Contribution to journalArticle

Phase II Clinical Trials
Leucovorin
Non-Small Cell Lung Carcinoma
Disease-Free Survival
Pneumatosis Cystoides Intestinalis
13 Citations (Scopus)

Phase II study of zoledronic acid combined with docetaxel for non-small-cell lung cancer: West Japan Oncology Group

Murakami, H., Yamanaka, T., Seto, T., Sugio, K., Okamoto, I., Sawa, T., Hirashima, T., Takeda, K., Atagi, S., Fukuoka, M., Nakanishi, Y., Nakagawa, K. & Yamamoto, N., Jan 1 2014, In : Cancer Science. 105, 8, p. 989-995 7 p.

Research output: Contribution to journalArticle

zoledronic acid
docetaxel
Non-Small Cell Lung Carcinoma
Japan
Confidence Intervals
32 Citations (Scopus)
erbB-1 Genes
Non-Small Cell Lung Carcinoma
Mutation
Survival
Protein-Tyrosine Kinases
40 Citations (Scopus)

The anti-HER3 antibody patritumab abrogates cetuximab resistance mediated by heregulin in colorectal cancer cells

Kawakami, H., Okamoto, I., Yonesaka, K., Okamoto, K., Shibata, K., Shinkai, Y., Sakamoto, H., Kitano, M., Tamura, T., Nishio, K. & Nakagawa, K., Jan 1 2014, In : Oncotarget. 5, 23, p. 11847-11856 10 p.

Research output: Contribution to journalArticle

Neuregulin-1
Anti-Idiotypic Antibodies
Colorectal Neoplasms
Phosphorylation
Cetuximab
69 Citations (Scopus)

Tyrosine phosphoproteomics identifies both codrivers and cotargeting strategies for T790M-related EGFR-TKI resistance in non-small cell lung cancer

Yoshida, T., Zhang, G., Smith, M. A., Lopez, A. S., Bai, Y., Li, J., Fang, B., Koomen, J., Rawal, B., Fisher, K. J., Chen, A. Y., Kitano, M., Morita, Y., Yamaguchi, H., Shibata, K., Okabe, T., Okamoto, I., Nakagawa, K. & Haura, E. B., Aug 1 2014, In : Clinical Cancer Research. 20, 15, p. 4059-4074 16 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Protein-Tyrosine Kinases
Tyrosine
src-Family Kinases
Phosphorylation
2013
14 Citations (Scopus)

A phase I, pharmacokinetic and pharmacodynamic study of nimotuzumab in Japanese patients with advanced solid tumors

Okamoto, W., Yoshino, T., Takahashi, T., Okamoto, I., Ueda, S., Tsuya, A., Boku, N., Nishio, K., Fukuoka, M., Yamamoto, N. & Nakagawa, K., Nov 1 2013, In : Cancer chemotherapy and pharmacology. 72, 5, p. 1063-1071 9 p.

Research output: Contribution to journalArticle

Pharmacodynamics
Pharmacokinetics
Epidermal Growth Factor Receptor
Toxicity
Tumors