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Research Output 1998 2019

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Article
2009
124 Citations (Scopus)

Phase I study of YM155, a novel survivin suppressant, in patients with advanced solid tumors

Satoh, T., Okamoto, I., Miyazaki, M., Morinaga, R., Tsuya, A., Hasegawa, Y., Terashima, M., Ueda, S., Fukuoka, M., Ariyoshi, Y., Saito, T., Masuda, N., Watanabe, H., Taguchi, T., Kakihara, T., Aoyama, Y., Hashimoto, Y. & Nakagawa, K., Jun 1 2009, In : Clinical Cancer Research. 15, 11, p. 3872-3880 9 p.

Research output: Contribution to journalArticle

Maximum Tolerated Dose
Neoplasms
Pharmacokinetics
Inhibitor of Apoptosis Proteins
Safety
61 Citations (Scopus)

Sorafenib inhibits non-small cell lung cancer cell growth by targeting B-RAF in KRAS wild-type cells and C-RAF in KRAS mutant cells

Takezawa, K., Okamoto, I., Yonesaka, K., Hatashita, E., Yamada, Y., Fukuoka, M. & Nakagawa, K., Aug 15 2009, In : Cancer Research. 69, 16, p. 6515-6521 7 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Growth
Extracellular Signal-Regulated MAP Kinases
Phosphorylation
sorafenib
58 Citations (Scopus)

SRPX2 is overexpressed in gastric cancer and promotes cellular migration and adhesion

Tamaka, K., Aran, T., Maegawa, M., Matsumoto, K., Kaneda, H., Kudo, K., Fujita, Y., Yokote, H., Yanagihara, K., Yamada, Y., Okamoto, I., Nakagawa, K. & Nishio, K., Mar 1 2009, In : International Journal of Cancer. 124, 5, p. 1072-1080 9 p.

Research output: Contribution to journalArticle

Stomach Neoplasms
Proteins
Focal Adhesion Protein-Tyrosine Kinases
HEK293 Cells
Gene Fusion

The role to be played by the specialty of tumor chemotherapy: a discussion

Eguchi, K., Tamura, K., Okamoto, I., Munakata, W. & Imamura, T., Aug 10 2009, In : Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine. 98, 8, p. 1959-1975 17 p.

Research output: Contribution to journalArticle

Palliative Care
Medicine
Drug Therapy
Neoplasms
3 Citations (Scopus)

Zoledronic acid-induced regression of multiple metastases at nonskeletal sites

Okamoto, K., Tsurutani, J., Terashima, M., Okamoto, I. & Nakagawa, K., Apr 7 2009, In : Annals of Oncology. 20, 4, p. 796-797 2 p.

Research output: Contribution to journalArticle

2008
43 Citations (Scopus)

A phase II trial of gefitinib monotherapy in Chemotherapy-Naïve patients of 75 years or older with advanced non-small cell lung cancer

Ebi, N., Semba, H., Tokunaga, S. J. I., Takayama, K., Wataya, H., Kuraki, T., Yamamoto, H., Akamine, S. J. I., Okamoto, I. & Nakanishi, Y., Oct 2008, In : Journal of Thoracic Oncology. 3, 10, p. 1166-1171 6 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Drug Therapy
Epidermal Growth Factor Receptor
gefitinib
Mutation
29 Citations (Scopus)

Association of epidermal growth factor receptor (EGFR) gene mutations with EGFR amplification in advanced non-small cell lung cancer

Morinaga, R., Okamoto, I., Fujita, Y., Arao, T., Sekijima, M., Nishio, K., Ito, H., Fukuoka, M., Kadota, J. I. & Nakagawa, K., Dec 12 2008, In : Cancer Science. 99, 12, p. 2455-2460 6 p.

Research output: Contribution to journalArticle

erbB-1 Genes
Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
Mutation
Scorpions
81 Citations (Scopus)

Enhancement of the antitumor activity of ionising radiation by nimotuzumab, a humanised monoclonal antibody to the epidermal growth factor receptor, in non-small cell lung cancer cell lines of differing epidermal growth factor receptor status

Akashi, Y., Okamoto, I., Iwasa, T., Yoshida, T., Suzuki, M., Hatashita, E., Yamada, Y., Satoh, T., Fukuoka, M., Ono, K. & Nakagawa, K., Feb 26 2008, In : British journal of cancer. 98, 4, p. 749-755 7 p.

Research output: Contribution to journalArticle

Antibodies, Monoclonal, Humanized
Ionizing Radiation
Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
Cell Line
10 Citations (Scopus)

Large cell neuroendocrine carcinoma of the mediastinum with α-fetoprotein production

Takezawa, K., Okamoto, I., Fukuoka, J., Tanaka, K., Kaneda, H., Uejima, H., Yoon, H. E., Imakita, M., Fukuoka, M. & Nakagawa, K., Feb 2008, In : Journal of Thoracic Oncology. 3, 2, p. 187-189 3 p.

Research output: Contribution to journalArticle

Fetal Proteins
Neuroendocrine Carcinoma
Large Cell Carcinoma
Mediastinum
Lung
40 Citations (Scopus)

Matuzumab and cetuximab activate the epidermal growth factor receptor but fail to trigger downstream signaling by Akt or Erk

Yoshida, T., Okamoto, I., Okabe, T., Iwasa, T., Satoh, T., Nishio, K., Fukuoka, M. & Nakagawa, K., Apr 1 2008, In : International Journal of Cancer. 122, 7, p. 1530-1538 9 p.

Research output: Contribution to journalArticle

Epidermal Growth Factor Receptor
Epidermal Growth Factor
Monoclonal Antibodies
Cell Survival
Phosphorylation

Molecular targeting therapy for treatment of non-small-cell lung carcinoma

Okamoto, I., Jan 1 2008, In : Gan to kagaku ryoho. Cancer & chemotherapy. 35, 8, p. 1303-1309 7 p.

Research output: Contribution to journalArticle

Antineoplastic Combined Chemotherapy Protocols
Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
Immunotherapy
Vascular Endothelial Growth Factor A
181 Citations (Scopus)

Multicentre prospective phase II trial of gefitinib for advanced non-small cell lung cancer with epidermal growth factor receptor mutations: Results of the West Japan Thoracic Oncology Group trial (WJTOG0403)

Tamura, K., Okamoto, I., Kashii, T., Negoro, S., Hirashima, T., Kudoh, S., Ichinose, Y., Ebi, N., Shibata, K., Nishimura, T., Katakami, N., Sawa, T., Shimizu, E., Fukuoka, J., Satoh, T. & Fukuoka, M., Mar 11 2008, In : British journal of cancer. 98, 5, p. 907-914 8 p.

Research output: Contribution to journalArticle

Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
Japan
Thorax
Mutation
111 Citations (Scopus)

Mutations in the LKB1 tumour suppressor are frequently detected in tumours from Caucasian but not Asian lung cancer patients

Koivunen, J. P., Kim, J., Lee, J., Rogers, A. M., Park, J. O., Zhao, X., Naoki, K., Okamoto, I., Nakagawa, K., Yeap, B. Y., Meyerson, M., Wong, K. K., Richards, W. G., Sugarbaker, D. J., Johnson, B. E. & Jänne, P. A., Jul 22 2008, In : British journal of cancer. 99, 2, p. 245-252 8 p.

Research output: Contribution to journalArticle

Lung Neoplasms
Mutation
Non-Small Cell Lung Carcinoma
Neoplasms
Squamous Cell Carcinoma
20 Citations (Scopus)
Non-Small Cell Lung Carcinoma
Meta-Analysis
Japan
Radiotherapy
Carboplatin
13 Citations (Scopus)

Pharmacokinetic analysis of carboplatin and etoposide in a small cell lung cancer patient undergoing hemodialysis

Takezawa, K., Okamoto, I., Fukuoka, M. & Nakagawa, K., Jan 1 2008, In : Journal of Thoracic Oncology. 3, 9, p. 1073-1075 3 p.

Research output: Contribution to journalArticle

Carboplatin
Small Cell Lung Carcinoma
Etoposide
Renal Dialysis
Pharmacokinetics
22 Citations (Scopus)

Phase II study of combination therapy with S-1 and irinotecan for advanced non-small cell lung cancer: West japan thoracic oncology group 3505

Okamoto, I., Nishimura, T., Miyazaki, M., Yoshioka, H., Kubo, A., Takeda, K., Ebi, N., Sugawara, S., Katakami, N., Fukuoka, M. & Nakagawa, K., Aug 15 2008, In : Clinical Cancer Research. 14, 16, p. 5250-5254 5 p.

Research output: Contribution to journalArticle

irinotecan
Non-Small Cell Lung Carcinoma
Japan
Thorax
Confidence Intervals
103 Citations (Scopus)

Radiosensitizing effect of YM155, a novel small-molecule survivin suppressant, in non-small cell lung cancer cell lines

Iwasa, T., Okamoto, I., Suzuki, M., Nakahara, T., Yamanaka, K., Hatashita, E., Yamada, Y., Fukuoka, M., Ono, K. & Nakagawa, K., Oct 15 2008, In : Clinical Cancer Research. 14, 20, p. 6496-6504 9 p.

Research output: Contribution to journalArticle

Radiation-Sensitizing Agents
Non-Small Cell Lung Carcinoma
Radiation
Cell Line
Heterografts
63 Citations (Scopus)

Synergistic antitumor effect of S-1 and the epidermal growth factor receptor inhibitor gefitinib in non-small cell lung cancer cell lines: Role of gefitinib-induced down-regulation of thymidylate synthase

Okabe, T., Okamoto, I., Tsukioka, S., Uchida, J., Iwasa, T., Yoshida, T., Hatashita, E., Yamada, Y., Satoh, T., Tamura, K., Fukuoka, M. & Nakagawa, K., Mar 1 2008, In : Molecular Cancer Therapeutics. 7, 3, p. 599-606 8 p.

Research output: Contribution to journalArticle

Thymidylate Synthase
Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
Down-Regulation
Cell Line
13 Citations (Scopus)

The anti-EGFR monoclonal antibody blocks cisplatin-induced activation of EGFR signaling mediated by HB-EGF

Yoshida, T., Okamoto, I., Iwasa, T., Fukuoka, M. & Nakagawa, K., Dec 24 2008, In : FEBS Letters. 582, 30, p. 4125-4130 6 p.

Research output: Contribution to journalArticle

Epidermal Growth Factor Receptor
Epidermal Growth Factor
Cisplatin
Heparin
Intercellular Signaling Peptides and Proteins
2007
117 Citations (Scopus)

Differential constitutive activation of the epidermal growth factor receptor in non-small cell lung cancer cells bearing EGFR gene mutation and amplification

Okabe, T., Okamoto, I., Tamura, K., Terashima, M., Yoshida, T., Satoh, T., Takada, M., Fukuoka, M. & Nakagawa, K., Mar 1 2007, In : Cancer Research. 67, 5, p. 2046-2053 8 p.

Research output: Contribution to journalArticle

erbB-1 Genes
Gene Amplification
Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
Mutation
17 Citations (Scopus)

Down-regulation of survivin by ultraviolet C radiation is dependent on p53 and results in G2-M arrest in A549 cells

Ikeda, M., Okamoto, I., Tamura, K., Satoh, T., Yonesaka, K., Fukuoka, M. & Nakagawa, K., Apr 18 2007, In : Cancer Letters. 248, 2, p. 292-298 7 p.

Research output: Contribution to journalArticle

Down-Regulation
Radiation
DNA Damage
RNA Interference
Lung Neoplasms
21 Citations (Scopus)

Oxaliplatin/fluorouracil/leucovorin (FOLFOX4 and modified FOLFOX6) in patients with refractory or advanced colorectal cancer: Post-approval Japanese population experience

Shimizu, T., Satoh, T., Tamura, K., Ozaki, T., Okamoto, I., Fukuoka, M. & Nakagawa, K., Jun 1 2007, In : International Journal of Clinical Oncology. 12, 3, p. 218-223 6 p.

Research output: Contribution to journalArticle

oxaliplatin
Leucovorin
Fluorouracil
Colorectal Neoplasms
Peripheral Nervous System Diseases
3 Citations (Scopus)

Phase I study of combination therapy with S-1 and weekly docetaxel for advanced gastric cancer

Ozaki, T., Tamura, K., Satoh, T., Kurata, T., Shimizu, T., Miyazaki, M., Okamoto, I., Nakagawa, K. & Fukuoka, M., Jul 1 2007, In : Anticancer research. 27, 4 C, p. 2657-2665 9 p.

Research output: Contribution to journalArticle

docetaxel
Stomach Neoplasms
Febrile Neutropenia
Pharmacokinetics
Stomatitis
79 Citations (Scopus)

Sequential occurrence of non-small cell and small cell lung cancer with the same EGFR mutation

Morinaga, R., Okamoto, I., Furuta, K., Kawano, Y., Sekijima, M., Dote, K., Satou, T., Nishio, K., Fukuoka, M. & Nakagawa, K., Dec 1 2007, In : Lung Cancer. 58, 3, p. 411-413 3 p.

Research output: Contribution to journalArticle

Small Cell Lung Carcinoma
Mutation
Non-Small Cell Lung Carcinoma
Exons
18 Citations (Scopus)

The novel microtubule-interfering agent TZT-1027 enhances the anticancer effect of radiation in vitro and in vivo

Akashi, Y., Okamoto, I., Suzuki, M., Tamura, K., Iwasa, T., Hisada, S., Satoh, T., Nakagawa, K., Ono, K. & Fukuoka, M., May 21 2007, In : British journal of cancer. 96, 10, p. 1532-1539 8 p.

Research output: Contribution to journalArticle

Radiation Effects
Microtubules
Radiation
Cell Cycle
Apoptosis
2006
19 Citations (Scopus)

Is the importance of achieving stable disease different between epidermal growth factor receptor tyrosine kinase inhibitors and cytotoxic agents in the second-line setting for advanced non-small cell lung cancer?

Kurata, T., Matsuo, K., Takada, M., Kawahara, M., Tsuji, M., Matsubara, Y., Otani, N., Matsuyama, S., Muraishi, K., Fujita, T., Ishikawa, M., Koyano, K., Okamoto, I., Satoh, T., Tamura, K., Nakagawa, K. & Fukuoka, M., Sep 1 2006, In : Journal of Thoracic Oncology. 1, 7, p. 684-691 8 p.

Research output: Contribution to journalArticle

Cytotoxins
Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
Protein-Tyrosine Kinases
PubMed
10 Citations (Scopus)

Pemetrexed-induced edema of the eyelid

Kurata, T., Tamura, K., Okamoto, I., Satoh, T., Nakagawa, K. & Fukuoka, M., Nov 1 2006, In : Lung Cancer. 54, 2, p. 241-242 2 p.

Research output: Contribution to journalArticle

Pemetrexed
Eyelids
Edema
Antimetabolites
Pamphlets
21 Citations (Scopus)

Pharmacokinetics of amrubicin and its active metabolite amrubicinol in lung cancer patients

Matsunaga, Y., Hamada, A., Okamoto, I., Sasaki, J. I., Moriyama, E., Kishi, H., Matsumoto, M., Hira, A., Watanabe, H. & Saito, H., Feb 1 2006, In : Therapeutic drug monitoring. 28, 1, p. 76-82 7 p.

Research output: Contribution to journalArticle

Lung Neoplasms
Pharmacokinetics
Area Under Curve
amrubicin
amrubicinol
29 Citations (Scopus)

Phase I and pharmacokinetic study of amrubicin, a synthetic 9-aminoanthracycline, in patients with refractory or relapsed lung cancer.

Okamoto, I., Hamada, A., Matsunaga, Y., Sasaki, J. I., Fujii, S., Uramoto, H., Yamagata, H., Mori, I., Kishi, H., Semba, H. & Saito, H., Jan 1 2006, In : Cancer chemotherapy and pharmacology. 57, 3, p. 282-288 7 p.

Research output: Contribution to journalArticle

Pharmacokinetics
Refractory materials
Lung Neoplasms
Area Under Curve
Maximum Tolerated Dose
264 Citations (Scopus)

Predictive factors for interstitial lung disease, antitumor response, and survival in non-small-cell lung cancer patients treated with gefitinib

Ando, M., Okamoto, I., Yamamoto, N., Takeda, K., Tamura, K., Seto, T., Ariyoshi, Y. & Fukuoka, M., Jun 1 2006, In : Journal of Clinical Oncology. 24, 16, p. 2549-2556 8 p.

Research output: Contribution to journalArticle

Interstitial Lung Diseases
Non-Small Cell Lung Carcinoma
Survival
Smoking
Histology
2005
37 Citations (Scopus)

Efficacy of the tyrosine kinase inhibitor gefitinib in a patient with metastatic small cell lung cancer

Araki, J., Okamoto, I., Suto, R., Ichikawa, Y. & Sasaki, J. I., Jan 1 2005, In : Lung Cancer. 48, 1, p. 141-144 4 p.

Research output: Contribution to journalArticle

Small Cell Lung Carcinoma
Protein-Tyrosine Kinases
Therapeutics
gefitinib
Epidermal Growth Factor Receptor
20 Citations (Scopus)

Phase II study of carboplatin-paclitaxel combination chemotherapy in elderly patients with advanced non-small cell lung cancer

Okamoto, I., Moriyama, E., Fujii, S., Kishi, H., Nomura, M., Goto, E., Kiyofuji, C., Imamura, F., Mori, T. & Matsumoto, M., Apr 1 2005, In : Japanese journal of clinical oncology. 35, 4, p. 188-194 7 p.

Research output: Contribution to journalArticle

Carboplatin
Paclitaxel
Combination Drug Therapy
Non-Small Cell Lung Carcinoma
Myalgia
2004
87 Citations (Scopus)

Deregulation and Mislocalization of the Cytokinesis Regulator ECT2 Activate the Rho Signaling Pathways Leading to Malignant Transformation

Saito, S., Liu, X. F., Kamijo, K., Raziuddin, R., Tatsumoto, T., Okamoto, I., Chen, X., Lee, C. C., Lorenzi, M. V., Ohara, N. & Miki, T., Feb 20 2004, In : Journal of Biological Chemistry. 279, 8, p. 7169-7179 11 p.

Research output: Contribution to journalArticle

rho GTP-Binding Proteins
Cytokinesis
Deregulation
Nuclear Localization Signals
Guanine Nucleotide Exchange Factors
2003
9 Citations (Scopus)

Absence of gallium uptake in unicentric and multicentric Castleman's disease

Okamoto, I., Iyonaga, K., Fujii, K., Mori, T., Yoshioka, M., Kohrogi, H., Matsumoto, M. & Suga, M., Aug 1 2003, In : Internal Medicine. 42, 8, p. 735-739 5 p.

Research output: Contribution to journalArticle

Giant Lymph Node Hyperplasia
Gallium
Lymphoproliferative Disorders
Radionuclide Imaging
Mediastinum
86 Citations (Scopus)

Constitutively active forms of c-Jun NH2-terminal kinase are expressed in primary glial tumors

Tsuiki, H., Tnani, M., Okamoto, I., Kenyon, L. C., Emlet, D. R., Holgado-Madruga, M., Lanham, I. S., Joynes, C. J., Vo, K. T. & Wong, A. J., Jan 1 2003, In : Cancer Research. 63, 1, p. 250-255 6 p.

Research output: Contribution to journalArticle

JNK Mitogen-Activated Protein Kinases
Neuroglia
Protein Isoforms
Neoplasms
Phosphotransferases
57 Citations (Scopus)

Diffuse alveolar damage after ZD1839 therapy in a patient with non-small cell lung cancer

Okamoto, I., Fujii, K., Matsumoto, M., Terasaki, Y., Kihara, N., Kohrogi, H. & Suga, M., Jun 1 2003, In : Lung Cancer. 40, 3, p. 339-342 4 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Therapeutics
Lung
X Ray Computed Tomography
Epidermal Growth Factor Receptor
110 Citations (Scopus)

Expression of constitutively activated EGFRvIII in non-small cell lung cancer

Okamoto, I., Kenyon, L. C., Emlet, D. R., Mori, T., Sasaki, J. I., Hirosako, S., Ichikawa, Y., Kishi, H., Godwin, A. K., Yoshioka, M., Suga, M., Matsumoto, M. & Wong, A. J., Jan 1 2003, In : Cancer Science. 94, 1, p. 50-56 7 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Epidermal Growth Factor Receptor
Lung
Neoplasms
epidermal growth factor receptor VIII
111 Citations (Scopus)

Presenilin-dependent γ-secretase activity mediates the intramembranous cleavage of CD44

Murakami, D., Okamoto, I., Nagano, O., Kawano, Y., Tomita, T., Iwatsubo, T., De Strooper, B., Yumoto, E. & Saya, H., Mar 13 2003, In : Oncogene. 22, 10, p. 1511-1516 6 p.

Research output: Contribution to journalArticle

Presenilins
Amyloid Precursor Protein Secretases
Tetradecanoylphorbol Acetate
Signal Transduction
Physiological Phenomena
42 Citations (Scopus)

Successful Treatment of Primary Pulmonary Angiosarcoma

Kojima, K., Okamoto, I., Ushijima, S., Yoshinaga, T., Kitaoka, M., Suga, M. & Sasaki, Y., Jan 1 2003, In : Chest. 124, 6, p. 2397-2400 4 p.

Research output: Contribution to journalArticle

Hemangiosarcoma
Lung
Therapeutics
Immunotherapy
Interleukin-2
2002
86 Citations (Scopus)

Elevated JNK activation contributes to the pathogenesis of human brain tumors

Antonyak, M. A., Kenyon, L. C., Godwin, A. K., James, D. C., Emlet, D. R., Okamoto, I., Tnani, M., Holgado-Madruga, M., Moscatello, D. K. & Wong, A. J., Aug 1 2002, In : Oncogene. 21, 33, p. 5038-5046 9 p.

Research output: Contribution to journalArticle

Brain Neoplasms
Tumor Cell Line
MAP Kinase Signaling System
Epidermal Growth Factor Receptor
Epidermal Growth Factor
123 Citations (Scopus)

Proteolytic cleavage of the CD44 adhesion molecule in multiple human tumors

Okamoto, I., Tsuiki, H., Kenyon, L. C., Godwin, A. K., Emlet, D. R., Holgado-Madruga, M., Lanham, I. S., Joynes, C. J., Vo, K. T., Guha, A., Matsumoto, M., Ushio, Y., Saya, H. & Wong, A. J., Jan 1 2002, In : American Journal of Pathology. 160, 2, p. 441-447 7 p.

Research output: Contribution to journalArticle

Neoplasms
Anti-Idiotypic Antibodies
Carcinoma
Membranes
Cell Adhesion Molecules
2001
267 Citations (Scopus)

Proteolytic release of CD44 intracellular domain and its role in the CD44 signaling pathway

Okamoto, I., Kawano, Y., Murakami, D., Sasayama, T., Araki, N., Miki, T., Wong, A. J. & Saya, H., Nov 26 2001, In : Journal of Cell Biology. 155, 5, p. 755-762 8 p.

Research output: Contribution to journalArticle

Transcriptional Activation
Cell Adhesion Molecules
p300-CBP Transcription Factors
Biological Phenomena
Metalloproteases
2000
57 Citations (Scopus)

Ras oncoprotein induces CD44 cleavage through phosphoinositide 3-OH kinase and the Rho family of small G proteins

Kawano, Y., Okamoto, I., Murakami, D., Itoh, H., Yoshida, M., Ueda, S. & Saya, H., Sep 22 2000, In : Journal of Biological Chemistry. 275, 38, p. 29628-29635 8 p.

Research output: Contribution to journalArticle

Monomeric GTP-Binding Proteins
Oncogene Proteins
Phosphatidylinositols
Phosphotransferases
Cells
1999
103 Citations (Scopus)

Calcium influx triggers the sequential proteolysis of extracellular and cytoplasmic domains of E-cadherin, leading to loss of β-catenin from cell-cell contacts

Ito, K., Okamoto, I., Araki, N., Kawano, Y., Nakao, M., Fujiyama, S., Tomita, K., Mimori, T. & Saya, H., Nov 25 1999, In : Oncogene. 18, 50, p. 7080-7090 11 p.

Research output: Contribution to journalArticle

Catenins
Cadherins
Proteolysis
Calcium
Metalloproteases
189 Citations (Scopus)

CD44 cleavage induced by a membrane-associated metalloprotease plays a critical role in tumor cell migration

Okamoto, I., Kawano, Y., Tsuiki, H., Sasaki, J. I., Nakao, M., Matsumoto, M., Suga, M., Ando, M., Nakajima, M. & Saya, H., Feb 18 1999, In : Oncogene. 18, 7, p. 1435-1446 12 p.

Research output: Contribution to journalArticle

Metalloproteases
Cell Movement
Membranes
Neoplasms
Extracellular Matrix
303 Citations (Scopus)

Human ECT2 is an exchange factor for Rho GTPases, phosphorylated in G2/M phases, and involved in cytokinesis

Tatsumoto, T., Xie, X., Blumenthal, R., Okamoto, I. & Miki, T., Nov 29 1999, In : Journal of Cell Biology. 147, 5, p. 921-927 7 p.

Research output: Contribution to journalArticle

rho GTP-Binding Proteins
Cytokinesis
G2 Phase
Cell Division
Interphase
84 Citations (Scopus)

Regulated CD44 cleavage under the control of protein kinase C, calcium influx, and the rho family of small G proteins

Okamoto, I., Kawano, Y., Matsumoto, M., Suga, M., Kaibuchi, K., Ando, M. & Saya, H., Sep 3 1999, In : Journal of Biological Chemistry. 274, 36, p. 25525-25534 10 p.

Research output: Contribution to journalArticle

Monomeric GTP-Binding Proteins
Tetradecanoylphorbol Acetate
Protein Kinase C
Acetates
Cells
1998
15 Citations (Scopus)

Expression of CD44 splicing isoforms in lung cancers: Dominant expression of CD44v8-10 in non-small cell lung carcinomas

Sasaki, J. I. I., Tanabe, K. K., Takahashi, K., Okamoto, I., Fujimoto, H., Matsumoto, M., Suga, M., Ando, M. & Saya, H., Mar 1 1998, In : International journal of oncology. 12, 3, p. 525-533 9 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Lung Neoplasms
Protein Isoforms
Lung
Small Cell Lung Carcinoma
19 Citations (Scopus)

Highly specific and sensitive detection of malignancy in urine samples from patients with urothelial cancer by CD44v8-10/CD44v10 competitive RT-PCR

Miyake, H., Okamoto, I., Hiara, I., Gohji, K., Yamanaka, K., Arakawa, S., Kamidono, S. & Saya, H., Dec 14 1998, In : International Journal of Cancer. 79, 6, p. 560-564 5 p.

Research output: Contribution to journalArticle

Urine
Polymerase Chain Reaction
Neoplasms
Reverse Transcription
Protein Isoforms
31 Citations (Scopus)

Interaction between CD44 and hyaluronic acid regulates human prostate cancer development

Miyake, H., Hara, I., Okamoto, I., Gohji, K., Yamanaka, K., Arakawa, S., Saya, H. & Kamidono, S., Jan 1 1998, In : Journal of Urology. 160, 4, p. 1562-1566 5 p.

Research output: Contribution to journalArticle

Hyaluronic Acid
Prostatic Neoplasms
Protein Isoforms
Aptitude
Human Development