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Research Output 2013 2019

  • 126 Citations
  • 7 h-Index
  • 16 Article
  • 1 Comment/debate
2019

An impaired intrinsic microglial clock system induces neuroinflammatory alterations in the early stage of amyloid precursor protein knock-in mouse brain

Ni, J., Wu, Z., Meng, J., Saito, T., Saido, T. C., Qing, H. & Nakanishi, H., Aug 30 2019, In : Journal of neuroinflammation. 16, 1, 173.

Research output: Contribution to journalArticle

Open Access
Amyloid beta-Protein Precursor
Microglia
Brain
Alzheimer Disease
Genes
1 Citation (Scopus)

Cathepsin E in neutrophils contributes to the generation of neuropathic pain in experimental autoimmune encephalomyelitis

Harada, Y., Zhang, J., Imari, K., Yamasaki, R., Ni, J., Wu, Z., Yamamoto, K., Kira, J. I., Nakanishi, H. & Hayashi, Y., Sep 1 2019, In : Pain. 160, 9, p. 2050-2062 13 p.

Research output: Contribution to journalArticle

Cathepsin E
Autoimmune Experimental Encephalomyelitis
Neuralgia
Neutrophils
Hyperalgesia
3 Citations (Scopus)

Increased expression and altered subcellular distribution of cathepsin B in microglia induce cognitive impairment through oxidative stress and inflammatory response in mice

Ni, J., Wu, Z., Stoka, V., Meng, J., Hayashi, Y., Peters, C., Qing, H., Turk, V. & Nakanishi, H., Feb 1 2019, In : Aging cell. 18, 1, e12856.

Research output: Contribution to journalArticle

Cathepsin B
Microglia
Oxidative Stress
Reactive Oxygen Species
Mitochondria
2018
1 Citation (Scopus)

Brazilian Green Propolis Prevents Cognitive Decline into Mild Cognitive Impairment in Elderly People Living at High Altitude

Zhu, A., Take, H., Zhong, X., Ni, J., Li, Y., Meng, J., Du, C., Zhao, X., Nakanishi, H. & Wu, S., Jan 1 2018, In : Journal of Alzheimer's Disease. 63, 2, p. 551-560 10 p.

Research output: Contribution to journalArticle

Propolis
Placebos
Inflammation
Serum
Interleukin-1
PAR-2 Receptor
Porphyromonas gingivalis
Microglia
Cell Movement
Infection
2 Citations (Scopus)

The critical role of IL-10 in the antineuroinflammatory and antioxidative effects of Rheum tanguticum on activated microglia

Meng, J., Ni, J., Wu, Z., Jiang, M., Zhu, A., Qing, H. & Nakanishi, H., Jan 1 2018, In : Oxidative medicine and cellular longevity. 2018, 1083596.

Research output: Contribution to journalArticle

Rheum
Microglia
Interleukin-10
Catechin
Interleukin-1
2017
2 Citations (Scopus)

Boi-ogi-to (TJ-20), a Kampo Formula, Suppresses the Inflammatory Bone Destruction and the Expression of Cytokines in the Synovia of Ankle Joints of Adjuvant Arthritic Rats

Zhang, X., Wu, Z., Liu, Y., Ni, J., Deng, C., Zhao, B., Nakanishi, H., He, J. & Yan, X., Jan 1 2017, In : Evidence-based Complementary and Alternative Medicine. 2017, 3679295.

Research output: Contribution to journalArticle

Kampo Medicine
Experimental Arthritis
Ankle Joint
Synovial Fluid
Rheumatoid Arthritis
24 Citations (Scopus)

Cathepsin B plays a critical role in inducing Alzheimer's disease-like phenotypes following chronic systemic exposure to lipopolysaccharide from Porphyromonas gingivalis in mice

Take, H., Ni, J., Liu, Y., Teeling, J. L., Takayama, F., Collcutt, A., Ibbett, P. & Nakanishi, H., Oct 1 2017, In : Brain, Behavior, and Immunity. 65, p. 350-361 12 p.

Research output: Contribution to journalArticle

Cathepsin B
Porphyromonas gingivalis
Microglia
Lipopolysaccharides
Alzheimer Disease
2 Citations (Scopus)
cathepsin S
PAR-2 Receptor
Porphyromonas gingivalis
Lipopolysaccharides
Interleukin-6
8 Citations (Scopus)

Infection of microglia with Porphyromonas gingivalis promotes cell migration and an inflammatory response through the gingipain-mediated activation of protease-activated receptor-2 in mice

Liu, Y., Take, H., Nakanishi, Y., Ni, J., Hayashi, Y., Takayama, F., Zhou, Y., Kadawaki, T. & Nakanishi, H., Dec 1 2017, In : Scientific reports. 7, 1, 11759.

Research output: Contribution to journalArticle

PAR-2 Receptor
Porphyromonas gingivalis
Extracellular Signal-Regulated MAP Kinases
Microglia
Cell Movement
1 Citation (Scopus)

Overexpression of Cathepsin E Interferes with Neuronal Differentiation of P19 Embryonal Teratocarcinoma Cells by Degradation of N-cadherin

Harada, Y., Takayama, F., Tanabe, K., Ni, J., Hayashi, Y., Yamamoto, K., Take, H. & Nakanishi, H., Apr 1 2017, In : Cellular and molecular neurobiology. 37, 3, p. 437-443 7 p.

Research output: Contribution to journalArticle

Cathepsin E
Teratocarcinoma
Cadherins
Neurons
Cell Differentiation
13 Citations (Scopus)

The Neuroprotective Effects of Brazilian Green Propolis on Neurodegenerative Damage in Human Neuronal SH-SY5Y Cells

Ni, J., Wu, Z., Meng, J., Zhu, A., Zhong, X., Wu, S. & Nakanishi, H., Jan 1 2017, In : Oxidative medicine and cellular longevity. 2017, 7984327.

Research output: Contribution to journalArticle

Propolis
Neuroprotective Agents
Brain-Derived Neurotrophic Factor
Cytoskeleton
Oxidative stress
2016
11 Citations (Scopus)

Cathepsin B Regulates Collagen Expression by Fibroblasts via Prolonging TLR2/NF-κB Activation

Li, X., Wu, Z., Ni, J., Liu, Y., Meng, J., Yu, W., Nakanishi, H. & Zhou, Y., Jan 1 2016, In : Oxidative medicine and cellular longevity. 2016, 7894247.

Research output: Contribution to journalArticle

Cathepsin B
Fibroblasts
Collagen
Chemical activation
yeast proteinase B
2015
16 Citations (Scopus)

Cathepsin D deficiency induces oxidative damage in brain pericytes and impairs the blood-brain barrier

Okada, R., Take, H., Zhu, A., Ni, J., Zhang, J., Yoshito, Y., Peters, C., Saftig, P. & Nakanishi, H., Jan 1 2015, In : Molecular and Cellular Neuroscience. 64, p. 51-60 10 p.

Research output: Contribution to journalArticle

Pericytes
Cathepsin D
Blood-Brain Barrier
Brain
Blood Cells
2 Citations (Scopus)

Salsolinol Damaged Neuroblastoma SH-SY5Y Cells Induce Proliferation of Human Monocyte THP-1 Cells Through the mTOR Pathway in a Co-culture System

Wang, F., Ni, J., Wang, X., Xie, B., Feng, C., Zhao, S., Saeed, Y., Qing, H. & Deng, Y., May 2015, In : Neurochemical Research. 40, 5, p. 932-41 10 p.

Research output: Contribution to journalArticle

Cell proliferation
Coculture Techniques
Neuroblastoma
Parkinson Disease
Monocytes
22 Citations (Scopus)

The critical role of proteolytic relay through cathepsins B and E in the phenotypic change of microglia/macrophage

Ni, J., Take, H., Peterts, C., Yamamoto, K., Qing, H. & Nakanishi, H., Sep 9 2015, In : Journal of Neuroscience. 35, 36, p. 12488-12501 14 p.

Research output: Contribution to journalArticle

Cathepsin E
Cathepsin B
Microglia
Macrophages
Phenotype
2013
18 Citations (Scopus)

Leptomeningeal cells transduce peripheral macrophages inflammatory signal to microglia in reponse to Porphyromonas gingivalis LPS

Liu, Y., Wu, Z., Zhang, X., Ni, J., Yu, W., Zhou, Y. & Nakanishi, H., Dec 1 2013, In : Mediators of Inflammation. 2013, 407562.

Research output: Contribution to journalArticle

Porphyromonas gingivalis
Microglia
Macrophages
Interleukin-1
Chronic Periodontitis