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Research Output 1997 2019

  • 1412 Citations
  • 22 h-Index
  • 31 Article
  • 6 Chapter
  • 4 Review article
  • 1 Letter
2019

A newly identified mutation in the PEX26 gene is associated with a milder form of Zellweger spectrum disorder

Tanaka, A. J., Okumoto, K., Tamura, S., Abe, Y., Hirsch, Y., Deng, L., Ekstein, J., Chung, W. K. & Fujiki, Y., Jan 1 2019, In : Cold Spring Harbor Molecular Case Studies. 5, 1, a003483.

Research output: Contribution to journalArticle

Zellweger Syndrome
Peroxisomes
Fibroblasts
Mutation
Genes
Open Access
Nucleoside-Diphosphate Kinase
nucleoside-diphosphate kinase
diphosphates
nucleosides
Guanosine Triphosphate
2018

A newly isolated Pex7-binding, atypical PTS2 protein P7BP2 is a novel dynein-type AAA+ protein

Niwa, H., Miyauchi-Nanri, Y., Okumoto, K., Mukai, S., Noi, K., Ogura, T. & Fujiki, Y., Dec 1 2018, In : Journal of Biochemistry. 164, 6, p. 437-447 11 p.

Research output: Contribution to journalArticle

Dyneins
Proteins
Peroxisomes
Sequence Alignment
Protein Transport

Cell death or survival against oxidative stress

Miyata, N., Okumoto, K. & Fujiki, Y., Jan 1 2018, Subcellular Biochemistry. Springer New York, p. 463-471 9 p. (Subcellular Biochemistry; vol. 89).

Research output: Chapter in Book/Report/Conference proceedingChapter

Peroxisomes
Oxidative stress
Cell death
Catalase
Cell Survival

Identification of peroxisomal protein complexes with PTS receptors, pex5 and pex7, in mammalian cells

Okumoto, K., Miyata, N. & Fujiki, Y., Jan 1 2018, Subcellular Biochemistry. Springer New York, p. 287-298 12 p. (Subcellular Biochemistry; vol. 89).

Research output: Chapter in Book/Report/Conference proceedingChapter

Cells
Proteins
Purification
Protein Interaction Maps
Peroxisomes
10 Citations (Scopus)

New splicing variants of mitochondrial Rho GTPase-1 (Miro1) transport peroxisomes

Okumoto, K., Ono, T., Toyama, R., Shimomura, A., Nagata, A. & Fujiki, Y., Feb 1 2018, In : Journal of Cell Biology. 217, 2, p. 619-633 15 p.

Research output: Contribution to journalArticle

rho GTP-Binding Proteins
Peroxisomes
Microtubules
Insertional Mutagenesis
Amino Acid Sequence
3 Citations (Scopus)

Onsite GTP fuelling via DYNAMO1 drives division of mitochondria and peroxisomes

Imoto, Y., Abe, Y., Honsho, M., Okumoto, K., Ohnuma, M., Kuroiwa, H., Kuroiwa, T. & Fujiki, Y., Dec 1 2018, In : Nature communications. 9, 1, 4634.

Research output: Contribution to journalArticle

Dynamins
Mitochondria
Fueling
Peroxisomes
mitochondria
2017
5 Citations (Scopus)

BAK regulates catalase release from peroxisomes

Fujiki, Y., Miyata, N., Mukai, S., Okumoto, K. & Cheng, E. H., Mar 17 2017, In : Molecular & Cellular Oncology . 4, 3, e1306610.

Research output: Contribution to journalArticle

Voltage-Dependent Anion Channel 2
Peroxisomes
Catalase
Permeability
Mitochondria

Blue native PAGE: Applications to study peroxisome biogenesis

Okumoto, K., Tamura, S. & Fujiki, Y., Jan 1 2017, Methods in Molecular Biology. Humana Press Inc., p. 197-205 9 p. (Methods in Molecular Biology; vol. 1595).

Research output: Chapter in Book/Report/Conference proceedingChapter

Native Polyacrylamide Gel Electrophoresis
Peroxisomes
Proteins
Membrane Proteins
Membranes
4 Citations (Scopus)

Defining the dynamin-based ring organizing center on the peroxisome-dividing machinery isolated from Cyanidioschyzon merolae

Imoto, Y., Abe, Y., Okumoto, K., Honsho, M., Kuroiwa, H., Kuroiwa, T. & Fujiki, Y., Jan 1 2017, In : Journal of Cell Science. 130, 5, p. 853-867 15 p.

Research output: Contribution to journalArticle

Dynamins
Peroxisomes
Guanosine Triphosphate
Rhodophyta
Plastids

Generation of peroxisome-deficient somatic animal cell mutants

Okumoto, K. & Fujiki, Y., Jan 1 2017, Methods in Molecular Biology. Humana Press Inc., p. 319-327 9 p. (Methods in Molecular Biology; vol. 1595).

Research output: Chapter in Book/Report/Conference proceedingChapter

Peroxisomes
Cricetulus
Ovary
Genes
Inborn Genetic Diseases
4 Citations (Scopus)

Localization of protein kinase NDR2 to peroxisomes and its role in ciliogenesis

Abe, S., Nagai, T., Masukawa, M., Okumoto, K., Homma, Y., Fujiki, Y. & Mizuno, K., Mar 10 2017, In : Journal of Biological Chemistry. 292, 10, p. 4089-4098 10 p.

Research output: Contribution to journalArticle

Peroxisomes
Protein-Serine-Threonine Kinases
Cell proliferation
Catalase
Protein Kinases

Peroxisomal membrane and matrix protein import using a semi-intact mammalian cell system

Okumoto, K., Honsho, M., Liu, Y. & Fujiki, Y., Jan 1 2017, Methods in Molecular Biology. Humana Press Inc., p. 213-219 7 p. (Methods in Molecular Biology; vol. 1595).

Research output: Chapter in Book/Report/Conference proceedingChapter

Membrane Proteins
Peroxisomes
Proteins
Plasmalogens
Metabolic Networks and Pathways
19 Citations (Scopus)

The VDAC2-BAK axis regulates peroxisomal membrane permeability

Hosoi, K., Miyata, N., Mukai, S., Furuki, S., Okumoto, K., Cheng, E. H. & Fujiki, Y., Mar 6 2017, In : Journal of Cell Biology. 216, 3, p. 709-722

Research output: Contribution to journalArticle

Peroxisomes
Permeability
Membranes
Peroxisomal Disorders
Inborn Genetic Diseases
2014
23 Citations (Scopus)

Distinct modes of ubiquitination of peroxisome-targeting signal type 1 (PTS1) receptor Pex5p regulate PTS1 protein import

Okumoto, K., Noda, H. & Fujiki, Y., May 16 2014, In : Journal of Biological Chemistry. 289, 20, p. 14089-14108 20 p.

Research output: Contribution to journalArticle

Peroxisomes
Ubiquitination
Lysine
Mammals
Ubiquitin-Protein Ligases
1 Citation (Scopus)

Molecular basis for peroxisome biogenesis disorders

Fujiki, Y., Okumoto, K., Mukai, S. & Tamura, S., Feb 1 2014, Molecular Machines Involved in Peroxisome Biogenesis and Maintenance. Springer-Verlag Wien, p. 91-110 20 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Peroxisomes
Zellweger Syndrome
Genes
Defects
Membranes
54 Citations (Scopus)

Peroxisome biogenesis in mammalian cells

Fujiki, Y., Okumoto, K., Mukai, S., Honsho, M. & Tamura, S., Jan 1 2014, In : Frontiers in Physiology. 5 AUG, Article 307.

Research output: Contribution to journalReview article

Peroxisomes
Cricetulus
Genes
Membranes
Ovary
2013
10 Citations (Scopus)

Pex5p stabilizes Pex14p: A study using a newly isolated pex5 CHO cell mutant, ZPEG101

Natsuyama, R., Okumoto, K. & Fujiki, Y., Jan 1 2013, In : Biochemical Journal. 449, 1, p. 195-207 13 p.

Research output: Contribution to journalArticle

Cricetulus
Ovary
Proteins
Binding Sites
Catalase
5 Citations (Scopus)

System to quantify the import of peroxisomal matrix proteins by fluorescence intensity

Noguchi, M., Okumoto, K. & Fujiki, Y., Jun 1 2013, In : Genes to Cells. 18, 6, p. 476-492 17 p.

Research output: Contribution to journalArticle

Peroxisomes
Fluorescence
Cytosol
Ligands
Proteins
2012
40 Citations (Scopus)

AWP1/ZFAND6 functions in Pex5 export by interacting with cys-monoubiquitinated Pex5 and Pex6 AAA ATPase

Miyata, N., Okumoto, K., Mukai, S., Noguchi, M. & Fujiki, Y., Jan 2012, In : Traffic. 13, 1, p. 168-183 16 p.

Research output: Contribution to journalArticle

Peroxisomes
Adenosine Triphosphatases
Assays
Fibroblasts
Fractionation
27 Citations (Scopus)
Peroxisomes
Membranes
Adenosine Triphosphatases
peroxisome-targeting signal 1 receptor
Hydrolysis
2011
70 Citations (Scopus)

Cysteine ubiquitination of PTS1 receptor Pex5p regulates Pex5p recycling

Okumoto, K., Misono, S., Miyata, N., Matsumoto, Y., Mukai, S. & Fujiki, Y., Aug 2011, In : Traffic. 12, 8, p. 1067-1083 17 p.

Research output: Contribution to journalArticle

Peroxisomes
Ubiquitination
Recycling
Cysteine
Dithiothreitol
33 Citations (Scopus)
Protease La
Trypsin
Peptide Hydrolases
Fatty Acids
Oxidation
2006
36 Citations (Scopus)

Lessons from peroxisome-deficient Chinese hamster ovary (CHO) cell mutants

Fujiki, Y., Okumoto, K., Kinoshita, N. & Ghaedi, K., Dec 1 2006, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1763, 12, p. 1374-1381 8 p.

Research output: Contribution to journalReview article

Peroxisomes
Cricetulus
Ovary
Genes
Organism Cloning
2003
33 Citations (Scopus)

CDNA cloning and characterization of the third isoform of human peroxin Pex11p

Tanaka, A., Okumoto, K. & Fujiki, Y., Jan 24 2003, In : Biochemical and Biophysical Research Communications. 300, 4, p. 819-823 5 p.

Research output: Contribution to journalArticle

Cloning
Organism Cloning
Protein Isoforms
Peroxisome Proliferators
Chromosomes, Human, Pair 19
2000
89 Citations (Scopus)
Peroxisomes
Yeast
Fingers
Assays
Anatomy
1 Citation (Scopus)

Peroxisome biogenesis and human disorders

Fujiki, Y. & Okumoto, K., Jan 1 2000, In : Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme. 45, 5, p. 691-699 9 p.

Research output: Contribution to journalReview article

PHEX Phosphate Regulating Neutral Endopeptidase
Peroxisomal Disorders
Peroxisomes
Molecular Cloning
Cricetinae
9 Citations (Scopus)

Peroxisome Biogenesis and Molecular Defects in Peroxisome Assembly Disorders

Fujiki, Y., Okumoto, K., Otera, H. & Tamura, S., Jan 1 2000, In : Cell Biochemistry and Biophysics. 32, p. 155-164 10 p.

Research output: Contribution to journalArticle

Peroxisomes
Membrane Proteins
Genes
Defects
Cricetulus
81 Citations (Scopus)

The peroxin Pex3p initiates membrane assembly in peroxisome biogenesis

Ghaedi, K., Tamura, S., Okumoto, K., Matsuzono, Y. & Fujiki, Y., Jan 1 2000, In : Molecular biology of the cell. 11, 6, p. 2085-2102 18 p.

Research output: Contribution to journalArticle

Peroxisomes
Membranes
Cricetulus
Amino Acids
Codon
1999
35 Citations (Scopus)

Isolation and characterization of novel peroxisome biogenesis-defective chinese hamster ovary cell mutants using green fluorescent-protein

Ghaedi, K., Kawai, A., Okumoto, K., Tamura, S., Shimozawa, N., Suzuki, Y., Kondo, N. & Fujiki, Y., May 1 1999, In : Experimental Cell Research. 248, 2, p. 489-497 9 p.

Research output: Contribution to journalArticle

Peroxisomes
Cricetulus
Green Fluorescent Proteins
Ovary
Rhizomelic Chondrodysplasia Punctata
127 Citations (Scopus)

The peroxin Pex14p: cDNA cloning by functional complementation on a Chinese hamster ovary cell mutant, characterization, and functional analysis

Shimizu, N., Itoh, R., Hirono, Y., Otera, H., Ghaedi, K., Tateishi, K., Tamura, S., Okumoto, K., Harano, T., Mukai, S. & Fujiki, Y., Apr 30 1999, In : Journal of Biological Chemistry. 274, 18, p. 12593-12604 12 p.

Research output: Contribution to journalArticle

Functional analysis
Peroxisomes
Cloning
Cricetulus
Rats
1998
58 Citations (Scopus)

Clofibrate-inducible, 28-kDa peroxisomal integral membrane protein is encoded by PEX11

Abe, I., Okumoto, K., Tamura, S. & Fujiki, Y., Jul 24 1998, In : FEBS Letters. 431, 3, p. 468-472 5 p.

Research output: Contribution to journalArticle

Clofibrate
Liver
lysyllysine
Membrane Proteins
Candida
81 Citations (Scopus)

Human PEX1 cloned by functional complementation on a CHO cell mutant is responsible for peroxisome-deficient Zellweger syndrome of complementation group I

Tamura, S., Okumoto, K., Toyama, R., Shimozawa, N., Tsukamoto, T., Suzuki, Y., Osumi, T., Kondo, N. & Fujiki, Y., Apr 14 1998, In : Proceedings of the National Academy of Sciences of the United States of America. 95, 8, p. 4350-4355 6 p.

Research output: Contribution to journalArticle

Zellweger Syndrome
Peroxisomes
Cricetulus
Peroxisomal Disorders
Ovary
86 Citations (Scopus)

Mutations in PEX10 is the cause of Zellweger peroxisome deficiency syndrome of complementation group B

Okumoto, K., Itoh, R., Shimozawa, N., Suzuki, Y., Tamura, S., Kondo, N. & Fujiki, Y., Sep 1 1998, In : Human Molecular Genetics. 7, 9, p. 1399-1405 7 p.

Research output: Contribution to journalArticle

Peroxisomes
Mutation
Complementary DNA
Fibroblasts
Zellweger Syndrome
48 Citations (Scopus)

Newly identified Chinese hamster ovary cell mutants are defective in biogenesis of peroxisomal membrane vesicles (peroxisomal ghosts), representing a novel complementation group in mammals

Kinoshita, N., Ghaedi, K., Shimozawa, N., Wanders, R. J. A., Matsuzono, Y., Imanaka, T., Okumoto, K., Suzuki, Y., Kondo, N. & Fujiki, Y., Sep 11 1998, In : Journal of Biological Chemistry. 273, 37, p. 24122-24130 9 p.

Research output: Contribution to journalArticle

Mammals
Peroxisomes
Cricetulus
Ovary
Cells
19 Citations (Scopus)

Peroxisome biogenesis disorders: Identification of a new complementation group distinct from peroxisome-deficient CHO mutants and not complemented by human PEX 13

Shimozawa, N., Suzuki, Y., Zhang, Z., Imamura, A., Tsukamoto, T., Osumi, T., Tateishi, K., Okumoto, K., Fujiki, Y., Orii, T., Barth, P. G., Wanders, R. J. A. & Kondo, N., Feb 13 1998, In : Biochemical and Biophysical Research Communications. 243, 2, p. 368-371 4 p.

Research output: Contribution to journalArticle

Peroxisomes
Genes
Rhizomelic Chondrodysplasia Punctata
CHO Cells
Yeast
150 Citations (Scopus)

Peroxisome targeting signal type 1 (PTS1) receptor is involved in import of both PTS1 and PTS2: Studies with PEX5-defective CHO cell mutants

Otera, H., Okumoto, K., Tateishi, K., Ikoma, Y., Matsuda, E., Nishimura, M., Tsukamoto, T., Osumi, T., Ohashi, K., Higuchi, O. & Fujiki, Y., Jan 1 1998, In : Molecular and Cellular Biology. 18, 1, p. 388-399 12 p.

Research output: Contribution to journalArticle

Peroxisomes
CHO Cells
Amino Acids
Protein Isoforms
Mutation
89 Citations (Scopus)

PEX12, the pathogenic gene of group III Zellweger syndrome: cDNA cloning by functional complementation on a CHO cell mutant, patient analysis, and characterization of Pex12p

Okumoto, K., Shimozawa, N., Kawai, A., Tamura, S., Tsukamoto, T., Osumi, T., Moser, H., Wanders, R. J. A., Suzuki, Y., Kondo, N. & Fujiki, Y., Jan 1 1998, In : Molecular and Cellular Biology. 18, 7, p. 4324-4336 13 p.

Research output: Contribution to journalArticle

Zellweger Syndrome
Peroxisomes
CHO Cells
Organism Cloning
Complementary DNA
1997
38 Citations (Scopus)

Isolation and characterization of peroxisome-deficient Chinese hamster ovary cell mutants representing human complementation group III

Okumoto, K., Bogaki, A., Tateishi, K., Tsukamoto, T., Osumi, T., Shimozawa, N., Suzuki, Y., Orii, T. & Fujiki, Y., May 25 1997, In : Experimental Cell Research. 233, 1, p. 11-20 10 p.

Research output: Contribution to journalArticle

Peroxisomes
Cricetulus
Ovary
Catalase
glycerone-phosphate O-acyltransferase
33 Citations (Scopus)

Isolation of a new peroxisome-deficient CHO cell mutant defective in peroxisome targeting signal-1 receptor

Tsukamoto, T., Bogaki, A., Okumoto, K., Tateishi, K., Fujiki, Y., Shimozawa, N., Suzuki, Y., Kondo, N. & Osumi, T., Jan 13 1997, In : Biochemical and Biophysical Research Communications. 230, 2, p. 402-406 5 p.

Research output: Contribution to journalArticle

Peroxisomes
CHO Cells
Complementary DNA
Rats
Genes
31 Citations (Scopus)

Newly identified Chinese hamster ovary cell mutants defective in peroxisome biogenesis represent two novel complementation groups in mammals

Tateishi, K., Okumoto, K., Shimozawa, N., Tsukamoto, T., Osumi, T., Suzuki, Y., Kondo, N., Okano, I. & Fujiki, Y., Jan 1 1997, In : European Journal of Cell Biology. 73, 4, p. 352-359 8 p.

Research output: Contribution to journalArticle

Peroxisomes
Cricetulus
Mammals
Ovary
Catalase
60 Citations (Scopus)

PEX12 encodes an integral membrane protein of peroxisomes

Okumoto, K. & Fujiki, Y., Jan 1 1997, In : Nature genetics. 17, 3, p. 265-266 2 p.

Research output: Contribution to journalLetter

Molecular Sequence Data
Zellweger Syndrome
Microbodies
Peroxisomes
ATP-Binding Cassette Transporters