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Research Output 1983 2019

  • 2974 Citations
  • 32 h-Index
  • 132 Article
  • 3 Review article
  • 1 Comment/debate
  • 1 Letter
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Article
2019

2,5-Dimethylcelecoxib prevents isoprenaline-induced cardiomyocyte hypertrophy and cardiac fibroblast activation by inhibiting Akt-mediated GSK-3 phosphorylation

Morishige, S., Takahashi-Yanaga, F., Ishikane, S., Arioka, M., Igawa, K., Kuroo, A., Tomooka, K., Shiose, A. & Sasaguri, T., Oct 2019, In : Biochemical Pharmacology. 168, p. 82-90 9 p.

Research output: Contribution to journalArticle

Glycogen Synthase Kinase 3
Phosphorylation
Cardiomegaly
Fibroblasts
Isoproterenol
1 Citation (Scopus)

Catalytic methane oxidation by a supramolecular conjugate based on a μ-nitrido-bridged iron porphyrinoid dimer

Yamada, Y., Morita, K., Mihara, N., Igawa, K., Tomooka, K. & Tanaka, K., Jan 1 2019, In : New Journal of Chemistry. 43, 29, p. 11477-11482 6 p.

Research output: Contribution to journalArticle

Rotaxanes
Porphyrins
Methane
Dimers
Iron
Open Access
STAT3 Transcription Factor
Cyclin D1
Cell Proliferation
Breast Neoplasms
STAT Transcription Factors
5 Citations (Scopus)

Site-Selective Supramolecular Complexation Activates Catalytic Ethane Oxidation by a Nitrido-Bridged Iron Porphyrinoid Dimer

Mihara, N., Yamada, Y., Takaya, H., Kitagawa, Y., Igawa, K., Tomooka, K., Fujii, H. & Tanaka, K., Mar 1 2019, In : Chemistry - A European Journal. 25, 13, p. 3369-3375 7 p.

Research output: Contribution to journalArticle

Ethane
Complexation
Dimers
Iron
Oxidation

Synthesis and stereochemical analysis of dynamic planar chiral nine-membered diallylic amide: Significant substituent effect on stereochemical stability

Hayashi, J. I., Uehara, K., Ano, Y., Kawasaki, Y., Igawa, K. & Tomooka, K., Jan 1 2019, In : Heterocycles. 99, 2, p. 856-864 9 p.

Research output: Contribution to journalArticle

Open Access
Stereochemistry
Enantiomers
Chirality
X ray analysis
Amides

Synthesis of NMs-DACN: Small and hydrophilic click reaction device

Kawasaki, Y., Yamanaka, Y., Seto, Y., Igawa, K. & Tomooka, K., Jan 1 2019, In : Chemistry Letters. 48, 5, p. 495-497 3 p.

Research output: Contribution to journalArticle

Azides
Copper
Solubility
Water
2018
12 Citations (Scopus)

Asymmetric Synthesis of Axially Chiral Benzocarbazole Derivatives Based on Catalytic Enantioselective Hydroarylation of Alkynes

Arae, S., Beppu, S., Kawatsu, T., Igawa, K., Tomooka, K. & Irie, R., Aug 17 2018, In : Organic Letters. 20, 16, p. 4796-4800 5 p.

Research output: Contribution to journalArticle

Alkynes
indoles
alkynes
Derivatives
Reaction intermediates
2 Citations (Scopus)
Silica Gel
Alkenes
Isomerization
Isomers
Molecules
3 Citations (Scopus)

Internal-Edge-Substituted Coumarin-Fused [6]Helicenes: Asymmetric Synthesis, Structural Features, and Control of Self-Assembly

Usui, K., Yamamoto, K., Ueno, Y., Igawa, K., Hagihara, R., Masuda, T., Ojida, A., Karasawa, S., Tomooka, K., Hirai, G. & Suemune, H., Oct 1 2018, In : Chemistry - A European Journal. 24, 55, p. 14617-14621 5 p.

Research output: Contribution to journalArticle

Self assembly
X ray crystallography
Quantum yield
Electronic structure
Physical properties
9 Citations (Scopus)

Transient Protection of Organic Azides from Click Reactions with Alkynes by Phosphazide Formation

Meguro, T., Yoshida, S., Igawa, K., Tomooka, K. & Hosoya, T., Jul 6 2018, In : Organic Letters. 20, 13, p. 4126-4130 5 p.

Research output: Contribution to journalArticle

azides (organic)
Alkynes
Azides
alkynes
sulfur
1 Citation (Scopus)

Vinylidene ortho-quinone methides: Unique chiral reaction intermediates in catalytic asymmetric synthesis

Arae, S., Furusawa, M., Beppu, S., Igawa, K., Tomooka, K. & Irie, R., Jan 1 2018, In : Chimia. 72, 12, p. 892-899 8 p.

Research output: Contribution to journalArticle

Reaction intermediates
Benzopyrans
Benzofurans
Carbazoles
Indoles
2017
7 Citations (Scopus)

2,5-Dimethylcelecoxib prevents pressure-induced left ventricular remodeling through GSK-3 activation

Fujita, A., Takahashi-Yanaga, F., Morimoto, S., Yoshihara, T., Arioka, M., Igawa, K., Tomooka, K., Hoka, S. & Sasaguri, T., Feb 1 2017, In : Hypertension Research. 40, 2, p. 130-139 10 p.

Research output: Contribution to journalArticle

Glycogen Synthase Kinase 3
Ventricular Remodeling
Pressure
Constriction
Heart Failure
7 Citations (Scopus)
Glycogen Synthase Kinase 3
Cell proliferation
Cell Movement
Tumors
Melanoma
13 Citations (Scopus)

Celecoxib and 2,5-dimethylcelecoxib inhibit intestinal cancer growth by suppressing the Wnt/β-catenin signaling pathway

Egashira, I., Takahashi-Yanaga, F., Nishida, R., Arioka, M., Igawa, K., Tomooka, K., Nakatsu, Y., Tsuzuki, T., Nakabeppu, Y., Kitazono, T. & Sasaguri, T., Jan 1 2017, In : Cancer Science. 108, 1, p. 108-115 8 p.

Research output: Contribution to journalArticle

Celecoxib
Intestinal Neoplasms
Catenins
Wnt Signaling Pathway
Growth
15 Citations (Scopus)

Construction of Condensed Polycyclic Aromatic Frameworks through Intramolecular Cycloaddition Reactions Involving Arynes Bearing an Internal Alkyne Moiety

Yoshida, S., Shimizu, K., Uchida, K., Hazama, Y., Igawa, K., Tomooka, K. & Hosoya, T., Nov 2 2017, In : Chemistry - A European Journal. 23, 61, p. 15332-15335 4 p.

Research output: Contribution to journalArticle

Bearings (structural)
Alkynes
Cycloaddition
Derivatives
Aromatic compounds
13 Citations (Scopus)

Oxygen Reduction to Water by a Cofacial Dimer of Iron(III)–Porphyrin and Iron(III)–Phthalocyanine Linked through a Highly Flexible Fourfold Rotaxane

Mihara, N., Yamada, Y., Takaya, H., Kitagawa, Y., Aoyama, S., Igawa, K., Tomooka, K. & Tanaka, K., Jan 1 2017, In : Chemistry - A European Journal. 23, 31, p. 7508-7514 7 p.

Research output: Contribution to journalArticle

Rotaxanes
Porphyrins
Dimers
Iron
Oxygen
10 Citations (Scopus)

Stereoselective Intramolecular Dearomatizative [4+2] Cycloaddition of Linked Ethynylnaphthol–Benzofuran Systems

Beppu, S., Arae, S., Furusawa, M., Arita, K., Fujimoto, H., Sumimoto, M., Imahori, T., Igawa, K., Tomooka, K. & Irie, R., Dec 15 2017, In : European Journal of Organic Chemistry. 2017, 46, p. 6914-6918 5 p.

Research output: Contribution to journalArticle

Cycloaddition
furans
cycloaddition
quinones
vinylidene
6 Citations (Scopus)

Synthesis and stereochemical properties of chiral hetero[7]helicenes structured by a benzodiheterole ring core

Arae, S., Mori, T., Kawatsu, T., Ueda, D., Shigeta, Y., Hamamoto, N., Fujimoto, H., Sumimoto, M., Imahori, T., Igawa, K., Tomooka, K., Punniyamurthy, T. & Irie, R., Jan 1 2017, In : Chemistry Letters. 46, 8, p. 1214-1216 3 p.

Research output: Contribution to journalArticle

Pyrroles
Chemical stability
Discrete Fourier transforms
Kinetics
Temperature
5 Citations (Scopus)

Synthesis of Stereoselectively Functionalized Silacyclopentanes

Igawa, K., Kuroo, A., Yoshihiro, D., Yamanaka, Y. & Tomooka, K., Nov 13 2017, In : Synlett. 28, 18, p. 2445-2448 4 p.

Research output: Contribution to journalArticle

Silicon
Carboxylic Acids
Amines
Substitution reactions
Carbon
6 Citations (Scopus)

Thieme Chemistry Journals Awardees: Where Are They Now? One-Pot Synthesis of Versatile Buckle Units for Click Chemistry: 4,8-Diazacyclononynes (DACNs)

Igawa, K., Aoyama, S., Kawasaki, Y., Kashiwagi, T., Seto, Y., Ni, R., Mitsuda, N. & Tomooka, K., Jan 1 2017, In : Synlett. 28, 16, p. 2110-2114 5 p.

Research output: Contribution to journalArticle

Copper
2-butyne-1,4-diol
2016
16 Citations (Scopus)

Enantioselective Synthesis of Silacyclopentanes

Igawa, K., Yoshihiro, D., Abe, Y. & Tomooka, K., May 4 2016, In : Angewandte Chemie - International Edition. 55, 19, p. 5814-5818 5 p.

Research output: Contribution to journalArticle

Serotonin Receptors
Discrete Fourier transforms
Oxides
Assays
Proteins
19 Citations (Scopus)

Rational Design and Synthesis of [5]Helicene-Derived Phosphine Ligands and Their Application in Pd-Catalyzed Asymmetric Reactions

Yamamoto, K., Shimizu, T., Igawa, K., Tomooka, K., Hirai, G., Suemune, H. & Usui, K., Nov 8 2016, In : Scientific reports. 6, 36211.

Research output: Contribution to journalArticle

phosphine
Ligands
Indoles
Acetates
Alcohols
5 Citations (Scopus)

Synthesis and Stereochemical Analysis of Planar-Chiral (E)-4-[7]Orthocyclophene

Igawa, K., Machida, K., Noguchi, K., Uehara, K. & Tomooka, K., Dec 2 2016, In : Journal of Organic Chemistry. 81, 23, p. 11587-11593 7 p.

Research output: Contribution to journalArticle

Chirality
Isomerization
Lewis Acids
Oxidation
Sulfones
19 Citations (Scopus)

Thiazolobenzyne: A versatile intermediate for multisubstituted benzothiazoles

Yoshida, S., Yano, T., Nishiyama, Y., Misawa, Y., Kondo, M., Matsushita, T., Igawa, K., Tomooka, K. & Hosoya, T., Jan 1 2016, In : Chemical Communications. 52, 75, p. 11199-11202 4 p.

Research output: Contribution to journalArticle

Benzothiazoles
Thiazoles
Iodine
Magnesium
benzyne
2015
9 Citations (Scopus)

Catalytic Enantioselective Synthesis of Planar-Chiral Cyclic Amides Based on a Pd-Catalyzed Asymmetric Allylic Substitution Reaction

Igawa, K., Ichikawa, N., Ano, Y., Katanoda, K., Ito, M., Akiyama, T. & Tomooka, K., Jun 17 2015, In : Journal of the American Chemical Society. 137, 23, p. 7294-7297 4 p.

Research output: Contribution to journalArticle

Cyclization
Amides
Substitution reactions
Ligands
9 Citations (Scopus)

Differentiation-inducing factor-3 inhibits intestinal tumor growth in vitro and in vivo

Kubokura, N., Takahashi-Yanaga, F., Arioka, M., Yoshihara, T., Igawa, K., Tomooka, K., Morimoto, S., Nakatsu, Y., Tsuzuki, T., Nakabeppu, Y., Matsumoto, T., Kitazono, T. & Sasaguri, T., Jan 1 2015, In : Journal of Pharmacological Sciences. 127, 4, p. 446-455 10 p.

Research output: Contribution to journalArticle

Growth
Neoplasms
Intestinal Neoplasms
Catenins
Dictyostelium
63 Citations (Scopus)

Direct Thioamination of Arynes via Reaction with Sulfilimines and Migratory N-Arylation

Yoshida, S., Yano, T., Misawa, Y., Sugimura, Y., Igawa, K., Shimizu, S., Tomooka, K. & Hosoya, T., Nov 11 2015, In : Journal of the American Chemical Society. 137, 44, p. 14071-14074 4 p.

Research output: Contribution to journalArticle

sulfilimine
44 Citations (Scopus)

Heteroatom-embedded medium-sized cycloalkynes: Concise synthesis, structural analysis, and reactions

Ni, R., Mitsuda, N., Kashiwagi, T., Igawa, K. & Tomooka, K., Jan 19 2015, In : Angewandte Chemie - International Edition. 54, 4, p. 1190-1194 5 p.

Research output: Contribution to journalArticle

Cycloparaffins
Alkynes
Cycloaddition
Structural analysis
Peptides

Synthesis, stereochemical characteristics, and coordination behavior of 2,2'-binaphthyl-1,1'-biisoquinoline as a new axially chiral bidentate ligand

Kawatsu, T., Tokushima, H., Takedomi, Y., Imahori, T., Igawa, K., Tomooka, K. & Irie, R., Jul 6 2015, In : Arkivoc. 2015, 4, p. 161-175 15 p.

Research output: Contribution to journalArticle

Ligands
Stereoisomerism
Chloroform
Temperature
X ray diffraction analysis
1 Citation (Scopus)

Synthesis and structural analysis of nine-membered enyne nitrogen heterocycles

Igawa, K., Kawabata, T., Uehara, K. & Tomooka, K., Jan 1 2015, In : Heterocycles. 90, 2, p. 901-906 6 p.

Research output: Contribution to journalArticle

Alkynes
Chirality
X ray analysis
Alkenes
Structural analysis
2014
44 Citations (Scopus)

An efficient generation method and remarkable reactivities of 3-triflyloxybenzyne

Yoshida, S., Uchida, K., Igawa, K., Tomooka, K. & Hosoya, T., Dec 11 2014, In : Chemical Communications. 50, 95, p. 15059-15062 4 p.

Research output: Contribution to journalArticle

Nucleophiles
Iodine
Magnesium
iodobenzene
3 Citations (Scopus)

Asymmetric ozone oxidation of silylalkenes using a C2- symmetrical dialkoxysilyl group as a chiral auxiliary

Igawa, K., Kawasaki, Y., Nishino, K., Mitsuda, N. & Tomooka, K., Jul 21 2014, In : Chemistry - A European Journal. 20, 30, p. 9255-9258 4 p.

Research output: Contribution to journalArticle

Ozone
Oxidation
Alkynes
Carbonyl compounds
Alkenes
16 Citations (Scopus)

DIF-1 inhibits tumor growth in vivo reducing phosphorylation of GSK-3β and expressions of cyclin D1 and TCF7L2 in cancer model mice

Takahashi-Yanaga, F., Yoshihara, T., Jingushi, K., Igawa, K., Tomooka, K., Watanabe, Y., Morimoto, S., Nakatsu, Y., Tsuzuki, T., Nakabeppu, Y. & Sasaguri, T., Jun 1 2014, In : Biochemical Pharmacology. 89, 3, p. 340-348 9 p.

Research output: Contribution to journalArticle

T Cell Transcription Factor 1
Glycogen Synthase Kinase 3
Phosphorylation
Cyclin D1
Tumors
2 Citations (Scopus)
Cyclization
Benzofurans
Benzopyrans
Heterocyclic Compounds
Benzene
9 Citations (Scopus)

Planar chiral dialkoxysilane: Introduction of inherent chirality and high reactivity in conventional achiral alkene

Tomooka, K., Miyasaka, S., Motomura, S. & Igawa, K., Jun 16 2014, In : Chemistry - A European Journal. 20, 25, p. 7598-7602 5 p.

Research output: Contribution to journalArticle

Epoxidation
Azides
Cycloaddition
Chirality
Alkenes
2013
22 Citations (Scopus)

Base-catalyzed Schmittel cycloisomerization of o-phenylenediyne-linked bis(arenol)s to indeno[1,2-c]chromenes

Furusawa, M., Arita, K., Imahori, T., Igawa, K., Tomooka, K. & Irie, R., Dec 25 2013, In : Tetrahedron Letters. 54, 52, p. 7107-7110 4 p.

Research output: Contribution to journalArticle

Benzopyrans
Cycloaddition
Cycloaddition Reaction
Transition metals
Metals
10 Citations (Scopus)

Oxidation of silanes to silanols on Pd nanoparticles: H2 desorption accelerated by surface oxygen atom

Kamachi, T., Shimizu, K. I., Yoshihiro, D., Igawa, K., Tomooka, K. & Yoshizawa, K., Nov 7 2013, In : Journal of Physical Chemistry C. 117, 44, p. 22967-22973 7 p.

Research output: Contribution to journalArticle

Silanes
silanes
oxygen atoms
Desorption
desorption
14 Citations (Scopus)

Palladium-catalyzed tandem cyclodehydrogenation of o-phenylenediyne-linked bis(arenol)s to produce benzodifuran-containing condensed heteroaromatic ring systems

Furusawa, M., Imahori, T., Igawa, K., Tomooka, K. & Irie, R., Oct 16 2013, In : Chemistry Letters. 42, 10, p. 1134-1136 3 p.

Research output: Contribution to journalArticle

Palladium
Water
Hysteresis loops
Freezing
Dielectric properties
4 Citations (Scopus)

Synthesis, structural analysis, and reaction of 3-Aza-5-[7]orthocyclophyne

Igawa, K., Kawabata, T., Ni, R. & Tomooka, K., Nov 11 2013, In : Chemistry Letters. 42, 11, p. 1374-1376 3 p.

Research output: Contribution to journalArticle

Chirality
Structural analysis
Halogenation
Temperature
2012
39 Citations (Scopus)

Catalytic enantioselective synthesis of alkenylhydrosilanes

Igawa, K., Yoshihiro, D., Ichikawa, N., Kokan, N. & Tomooka, K., Dec 14 2012, In : Angewandte Chemie - International Edition. 51, 51, p. 12745-12748 4 p.

Research output: Contribution to journalArticle

Silanes
Alkenylation
Alkynes
Hydrides
Catalysts
21 Citations (Scopus)

Nucleophilic substitution reaction at the nitrogen of arylsulfonamides with phosphide anion

Yoshida, S., Igawa, K. & Tomooka, K., Nov 28 2012, In : Journal of the American Chemical Society. 134, 47, p. 19358-19361 4 p.

Research output: Contribution to journalArticle

Amines
Anions
Substitution reactions
Nitrogen
Negative ions
14 Citations (Scopus)

Planar-chiral [7]orthocyclophanes

Tomooka, K., Iso, C., Uehara, K., Suzuki, M., Nishikawa-Shimono, R. & Igawa, K., Oct 8 2012, In : Angewandte Chemie - International Edition. 51, 41, p. 10355-10358 4 p.

Research output: Contribution to journalArticle

Chirality
Nitrogen
Molecules
Temperature
2011
12 Citations (Scopus)

Addition-type oxidation of silylalkene using ozone: An efficient approach for acyloin and its derivatives

Igawa, K., Kawasaki, Y. & Tomooka, K., Feb 28 2011, In : Chemistry Letters. 40, 3, p. 233-235 3 p.

Research output: Contribution to journalArticle

Ozone
Derivatives
Oxidation
Alkynes
Ketones
14 Citations (Scopus)
Celecoxib
Dilated Cardiomyopathy
Signal Transduction
Cyclooxygenase 2
2,5-dimethylcelecoxib
60 Citations (Scopus)

Directing group-controlled hydrosilylation: Regioselective functionalization of alkyne

Kawasaki, Y., Ishikawa, Y., Igawa, K. & Tomooka, K., Dec 28 2011, In : Journal of the American Chemical Society. 133, 51, p. 20712-20715 4 p.

Research output: Contribution to journalArticle

Hydrosilylation
Alkynes
Regioselectivity
Alkenes
Olefins
17 Citations (Scopus)

Dynamic chirality of (E)-5-cyclononen-1-one and its enolate

Tomooka, K., Ezawa, T., Inoue, H., Uehara, K. & Igawa, K., Feb 16 2011, In : Journal of the American Chemical Society. 133, 6, p. 1754-1756 3 p.

Research output: Contribution to journalArticle

Chirality
Hydrolysis
Nucleophiles
Enzymatic hydrolysis
13 Citations (Scopus)

Stereoselective multimodal transformations of planar chiral 9-membered diallylic amides

Tomooka, K., Suzuki, M., Shimada, M., Ni, R. & Uehara, K., Sep 16 2011, In : Organic Letters. 13, 18, p. 4926-4929 4 p.

Research output: Contribution to journalArticle

Amides
amides
Lewis Acids
Chirality
chirality
3 Citations (Scopus)

Synthesis and stereochemical behavior of (E)-cyclononene derivatives

Tomooka, K., Inoue, H. & Igawa, K., May 27 2011, In : Chemistry Letters. 40, 6, p. 591-593 3 p.

Research output: Contribution to journalArticle

Chirality
Derivatives
Molecules
Esters
20 Citations (Scopus)

Synthesis and stereochemical behavior of a new chiral oxa[7]heterohelicene

Irie, R., Tanoue, A., Urakawa, S., Imahori, T., Igawa, K., Matsumoto, T., Tomooka, K., Kikuta, S., Uchida, T. & Katsuki, T., Nov 30 2011, In : Chemistry Letters. 40, 12, p. 1343-1345 3 p.

Research output: Contribution to journalArticle

Cyclization
Palladium
Dimethyl Sulfoxide
Discrete Fourier transforms
Acetates
2010
33 Citations (Scopus)

Asymmetrie synthesis of chiral silacarboxylic acids and their ester derivatives

Igawa, K., Kokan, N. & Tomooka, K., Jan 18 2010, In : Angewandte Chemie - International Edition. 49, 4, p. 728-731 4 p.

Research output: Contribution to journalArticle

Esters
Derivatives
Acids
Silicon
Atoms