• 15729 Citations
  • 64 h-Index
1974 …2019
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Research Output 1974 2019

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Review article
2019
1 Citation (Scopus)

Role of the P2X4 receptor in neuropathic pain

Inoue, K., Aug 1 2019, In : Current Opinion in Pharmacology. 47, p. 33-39 7 p.

Research output: Contribution to journalReview article

Purinergic P2X4 Receptors
Neuralgia
Purinergic P2 Receptors
Pain
Peripheral Nerve Injuries
2018
1 Citation (Scopus)

A state-of-the-art perspective on microgliopathic pain

Inoue, K., Nov 1 2018, In : Open Biology. 8, 11, 180154.

Research output: Contribution to journalReview article

Microglia
Neuralgia
Pain
Peripheral Nerve Injuries
Chronic Pain

Green Pharma: A new strategy for drug discovery in academia by targeting glial cells and ATP receptors

Yamashita, T., Makoto, T., Saitoh, H. & Inoue, K., Jan 1 2018, In : Yakugaku Zasshi. 138, 8, p. 1027-1031 5 p.

Research output: Contribution to journalReview article

Purinergic P2 Receptors
Drug Discovery
Neuroglia
Hyperalgesia
Neuralgia
41 Citations (Scopus)

Microglia in neuropathic pain: Cellular and molecular mechanisms and therapeutic potential

Inoue, K. & Makoto, T., Feb 16 2018, In : Nature Reviews Neuroscience. 19, 3, p. 138-152 15 p.

Research output: Contribution to journalReview article

Microglia
Neuralgia
Chronic Pain
Nociceptive Pain
Peripheral Nerve Injuries
2017
7 Citations (Scopus)

Neuropharmacological study of atp receptors, especially in the relationship between glia and pain

Inoue, K., Jan 1 2017, In : Yakugaku Zasshi. 137, 5, p. 563-569 7 p.

Research output: Contribution to journalReview article

Microglia
Neuroglia
Pain
Purinergic P2X4 Receptors
Neuralgia
12 Citations (Scopus)
pathogenesis
Purinergic P2X4 Receptors
pain
neuroglia
Microglia
2016
39 Citations (Scopus)

Neuron-microglia interaction by purinergic signaling in neuropathic pain following neurodegeneration

Makoto, T. & Inoue, K., May 1 2016, In : Neuropharmacology. 104, p. 76-81 6 p.

Research output: Contribution to journalReview article

Microglia
Neuralgia
Neurons
Purinergic P2Y Receptors
Purinergic P2X Receptors
2013
77 Citations (Scopus)

Microglial regulation of neuropathic pain

Makoto, T., Masuda, T., Saitoh, H. & Inoue, K., Feb 26 2013, In : Journal of Pharmacological Sciences. 121, 2, p. 89-94 6 p.

Research output: Contribution to journalReview article

Neuralgia
Microglia
Wounds and Injuries
Posterior Horn Cells
Gene Expression
59 Citations (Scopus)

P2X4 receptors and neuropathic pain

Tsuda, M., Masuda, T., Tozaki-Saitoh, H. & Inoue, K., Oct 28 2013, In : Frontiers in Cellular Neuroscience. OCT, 191.

Research output: Contribution to journalReview article

Purinergic P2X4 Receptors
Microglia
Neuralgia
Chemokine CCL21
CCR Receptors
2 Citations (Scopus)

The Neuropharmacological study for ATP receptors especially in pain

Inoue, K., Jan 1 2013, In : Yakugaku Zasshi. 133, 10, p. 1035-1039 5 p.

Research output: Contribution to journalReview article

Purinergic P2 Receptors
Microglia
Purinergic P2X4 Receptors
Neuralgia
Pain
2012
8 Citations (Scopus)

P2Y receptors in microglia and neuroinflammation

Saitoh, H., Makoto, T. & Inoue, K., Jul 1 2012, In : Wiley Interdisciplinary Reviews: Membrane Transport and Signaling. 1, 4, p. 493-501 9 p.

Research output: Contribution to journalReview article

Microglia
Central Nervous System
Purinergic Receptors
Cytophagocytosis
Uridine Diphosphate
40 Citations (Scopus)

Purinergic system, microglia and neuropathic pain

Makoto, T., Saitoh, H. & Inoue, K., Feb 1 2012, In : Current Opinion in Pharmacology. 12, 1, p. 74-79 6 p.

Research output: Contribution to journalReview article

Microglia
Neuralgia
Purinergic Receptors
Peripheral Nerve Injuries
Neuroglia
47 Citations (Scopus)

Purinergic systems, neuropathic pain and the role of microglia

Inoue, K. & Makoto, T., Apr 1 2012, In : Experimental Neurology. 234, 2, p. 293-301 9 p.

Research output: Contribution to journalReview article

Purinergic Receptors
Microglia
Neuralgia
Purinergic P2Y12 Receptors
Purinergic P2X4 Receptors
9 Citations (Scopus)

Role of the glia in neuropathic pain caused by peripheral nerve injury

Inoue, K., Makoto, T. & Saitoh, H., Nov 2012, In : Brain and Nerve. 64, 11, p. 1233-1239 7 p.

Research output: Contribution to journalReview article

Peripheral Nerve Injuries
Neuralgia
Neuroglia
Microglia
Astrocytes
2011
14 Citations (Scopus)

Platelet-activating factor and pain

Makoto, T., Saitoh, H. & Inoue, K., Aug 1 2011, In : Biological and Pharmaceutical Bulletin. 34, 8, p. 1159-1162 4 p.

Research output: Contribution to journalReview article

Platelet Activating Factor
Pain
Neuralgia
Spinal Ganglia
Wounds and Injuries
2010
91 Citations (Scopus)

Pain and purinergic signaling

Makoto, T., Saitoh, H. & Inoue, K., May 1 2010, In : Brain Research Reviews. 63, 1-2, p. 222-232 11 p.

Research output: Contribution to journalReview article

Purinergic P2 Receptors
Microglia
Peripheral Nerve Injuries
Nucleotides
Second Messenger Systems
1 Citation (Scopus)

Purinergic regulation of microglia

Saitoh, H., Makoto, T. & Inoue, K., Oct 12 2010, In : Folia Pharmacologica Japonica. 136, 2, p. 93-97 5 p.

Research output: Contribution to journalReview article

Purinergic P2Y12 Receptors
Purinergic P2X4 Receptors
Purinergic P2X7 Receptors
Purinergic P2 Receptors
Microglia
2009
184 Citations (Scopus)

Microglia and neuropathic pain

Inoue, K. & Makoto, T., Nov 27 2009, In : GLIA. 57, 14, p. 1469-1479 11 p.

Research output: Contribution to journalReview article

Microglia
Neuralgia
Pain
Wounds and Injuries
Posterior Horn Cells

Regulation of brain function mediated by glial ATP sensors

Koizumi, S. & Inoue, K., 2009, In : Seikagaku. 81, 1, p. 35-38 4 p.

Research output: Contribution to journalReview article

Purinergic P2 Receptors
Microglia
Phagocytosis
Cell Communication
Neuroglia

Role of extracellular nucleotides and their receptors in chronic pain

Makoto, T. & Inoue, K., Oct 1 2009, In : Seikagaku. 81, 10, p. 884-890 7 p.

Research output: Contribution to journalReview article

Symporters
Purinergic P2 Receptors
Signal transduction
Drug Design
Brain-Derived Neurotrophic Factor
2008
89 Citations (Scopus)

Purinergic systems in microglia

Inoue, K., Oct 1 2008, In : Cellular and Molecular Life Sciences. 65, 19, p. 3074-3080 7 p.

Research output: Contribution to journalReview article

Microglia
Nucleotides
Purinergic P2 Receptors
Second Messenger Systems
Purinergic P2X4 Receptors

The role of microglia in neuropathic pain: challenging of eco-pharma

Inoue, K., Jan 1 2008, In : Fukuoka igaku zasshi = Hukuoka acta medica. 99, 12, p. 239-245 7 p.

Research output: Contribution to journalReview article

Microglia
Neuralgia
2007
23 Citations (Scopus)

Modification of neuropathic pain sensation through microglial ATP receptors

Inoue, K., Makoto, T. & Saitoh, H., Sep 1 2007, In : Purinergic Signalling. 3, 4, p. 311-316 6 p.

Research output: Contribution to journalReview article

Purinergic P2 Receptors
Neuralgia
Microglia
Peripheral Nerves
Neuroglia
420 Citations (Scopus)

Neuronal 'On' and 'Off' signals control microglia

Biber, K., Neumann, H., Inoue, K. & Boddeke, H. W. G. M., Nov 1 2007, In : Trends in Neurosciences. 30, 11, p. 596-602 7 p.

Research output: Contribution to journalReview article

Microglia
Neurons
Purines
Chemokines
Glutamic Acid
5 Citations (Scopus)

Neuropathic pain and ATP receptors in spinal microglia

Makoto, T. & Inoue, K., Sep 2007, In : Brain and Nerve. 59, 9, p. 953-959 7 p.

Research output: Contribution to journalReview article

Purinergic P2 Receptors
Nociceptors
Microglia
Neuralgia
Purinergic P2X4 Receptors
42 Citations (Scopus)

P2 receptors and chronic pain

Inoue, K., Mar 1 2007, In : Purinergic Signalling. 3, 1-2, p. 135-144 10 p.

Research output: Contribution to journalReview article

Purinergic P2X4 Receptors
Neuralgia
Purinergic P2 Receptors
Chronic Pain
Purinergic P2X3 Receptors
83 Citations (Scopus)

The role of nucleotides in the neuron-glia communication responsible for the brain functions

Inoue, K., Koizumi, S. & Makoto, T., Sep 1 2007, In : Journal of Neurochemistry. 102, 5, p. 1447-1458 12 p.

Research output: Contribution to journalReview article

Neuroglia
Neurons
Brain
Nucleotides
Microglia
14 Citations (Scopus)

UDP facilitates microglial phagocytosis through P2Y6 receptors.

Inoue, K., Jan 1 2007, In : Cell adhesion & migration. 1, 3, p. 131-132 2 p.

Research output: Contribution to journalReview article

Uridine Diphosphate
Microglia
Phagocytosis
Kainic Acid
Hippocampal CA3 Region
2006
1 Citation (Scopus)

ATP receptors in pain

Inoue, K., 2006, In : Folia Pharmacologica Japonica. 127, 3, p. 166-170 5 p.

Research output: Contribution to journalReview article

Purinergic P2 Receptors
Microglia
Pain

Role of molecules expressed in spiral microglia in neuropathic pain

Tsuda, M. & Inoue, K., Feb 2006, In : Japanese Journal of Psychopharmacology. 26, 1, p. 57-61 5 p.

Research output: Contribution to journalReview article

Microglia
Neuralgia
Pain
Purinergic P2X4 Receptors
Peripheral Nerves
241 Citations (Scopus)

The function of microglia through purinergic receptors: Neuropathic pain and cytokine release

Inoue, K., Jan 1 2006, In : Pharmacology and Therapeutics. 109, 1-2, p. 210-226 17 p.

Research output: Contribution to journalReview article

Purinergic Receptors
Microglia
Neuralgia
Cytokines
Purinergic P2X4 Receptors
15 Citations (Scopus)

The role of microglia and ATP receptors in a mechanism of neuropathic pain

Inoue, K. & Makoto, T., Dec 1 2006, In : Folia Pharmacologica Japonica. 127, 1, p. 14-17 4 p.

Research output: Contribution to journalReview article

Purinergic P2 Receptors
Microglia
Neuralgia
Pain
2005
25 Citations (Scopus)

ATP receptors in pain sensation: Involvement of spinal microglia and P2X4 receptors

Inoue, K., Makoto, T. & Koizumi, S., Jun 1 2005, In : Purinergic Signalling. 1, 2, p. 95-100 6 p.

Research output: Contribution to journalReview article

Purinergic P2X4 Receptors
Purinergic P2 Receptors
Microglia
Neuralgia
Pain
584 Citations (Scopus)

Neuropathic pain and spinal microglia: A big problem from molecules in 'small' glia

Makoto, T., Inoue, K. & Salter, M. W., Feb 1 2005, In : Trends in Neurosciences. 28, 2, p. 101-107 7 p.

Research output: Contribution to journalReview article

Microglia
Neuralgia
Neuroglia
Pain
Wounds and Injuries
32 Citations (Scopus)

Regulation of cell-to-cell communication mediated by astrocytic ATP in the CNS

Koizumi, S., Fujishita, K. & Inoue, K., Sep 1 2005, In : Purinergic Signalling. 1, 3, p. 211-217 7 p.

Research output: Contribution to journalReview article

Cell Communication
Astrocytes
Adenosine Triphosphate
Neurons
Synaptic Transmission
2004
1 Citation (Scopus)

ATP and neuropathic pain

Inoue, K., Makoto, T. & Koizumi, S., Jan 1 2004, In : Seikagaku. The Journal of Japanese Biochemical Society. 76, 11, p. 1431-1439 9 p.

Research output: Contribution to journalReview article

Purinergic P2 Receptors
Signal transduction
Uridine Triphosphate
Gene expression
Animals
1 Citation (Scopus)

ATP receptors in pain sensation

Inoue, K., Makoto, T. & Koizumi, S., Nov 8 2004, In : Folia Pharmacologica Japonica. 124, 4, p. 228-233 6 p.

Research output: Contribution to journalReview article

Purinergic P2 Receptors
Hyperalgesia
Pain
Unmyelinated Nerve Fibers
Diagnosis-Related Groups
6 Citations (Scopus)

Regulation by astrocytic ATP of synaptic transmission

Koizumi, S. & Inoue, K., Jul 14 2004, In : Folia Pharmacologica Japonica. 123, 6, p. 389-396 8 p.

Research output: Contribution to journalReview article

Synaptic Transmission
Astrocytes
Adenosine Triphosphate
Neurons
Neurotransmitter Agents
2002
244 Citations (Scopus)

Microglial activation by purines and pyrimidines

Inoue, K., Nov 1 2002, In : GLIA. 40, 2, p. 156-163 8 p.

Research output: Contribution to journalReview article

Pyrimidines
Purines
Microglia
Adenosine Triphosphate
Interleukin-6
2000
1 Citation (Scopus)

ATP receptors in pain

Makoto, T., Koizumi, S. & Inoue, K., Jan 1 2000, In : Folia Pharmacologica Japonica. 116, 6, p. 343-350 8 p.

Research output: Contribution to journalReview article

Purinergic P2X3 Receptors
Purinergic P2 Receptors
Capsaicin
Hyperalgesia
Purinergic P2X2 Receptors
1999
26 Citations (Scopus)

The functions of ATP receptors in the synaptic transmission in the hippocampus

Inoue, K., Koizumi, S., Ueno, S., Kita, A. & Makoto, T., Jan 1 1999, In : Progress in Brain Research. 120, p. 193-206 14 p.

Research output: Contribution to journalReview article

Purinergic P2 Receptors
Synaptic Transmission
Hippocampus
1998
26 Citations (Scopus)

ATP receptors for the protection of hippocampal functions

Inoue, K., Dec 1998, In : Japanese Journal of Pharmacology. 78, 4, p. 405-410 6 p.

Research output: Contribution to journalReview article

Adenosine Triphosphate
Glutamic Acid
GABAergic Neurons
Plasminogen
Dopaminergic Neurons

Signal transduction through ATP receptors in brain and the development of new drugs

Inoue, K., Koizumi, S., Ueno, S. & Makoto, T., Jan 1 1998, In : Nippon yakurigaku zasshi. Folia pharmacologica Japonica. 112 Suppl 1

Research output: Contribution to journalReview article

Signal Transduction
Adenosine Triphosphate
Brain
Pharmaceutical Preparations
Hippocampus
1997
1 Citation (Scopus)

ATP receptors

Inoue, K., Jan 1 1997, In : Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme. 42, 3 Suppl, p. 308-315 8 p.

Research output: Contribution to journalReview article

Purinergic P2 Receptors
Autonomic Nervous System
Ion Channels
GTP-Binding Proteins
Synaptic Transmission
1 Citation (Scopus)

ATP receptors in the central nervous system

Inoue, K., Jan 1 1997, In : Folia Pharmacologica Japonica. 110, 4, p. 173-182 10 p.

Research output: Contribution to journalReview article

Purinergic P2 Receptors
Central Nervous System
Neurons
Trigeminal Ganglion
Diagnosis-Related Groups
1995

ATP as a neurotransmitter in the brain: Its possibility based upon recent findings

Nakazawa, K., Koizumi, S. & Inoue, K., 1995, In : Japanese Journal of Psychopharmacology. 15, 1, p. 1-11 11 p.

Research output: Contribution to journalReview article

Neurotransmitter Agents
Adenosine Triphosphate
Brain
Purinergic P2 Receptors
Neurons
1992

ATP receptor and neurotransmitter release

Inoue, K. & Nakazawa, K., Jan 1 1992, In : Seikagaku. The Journal of Japanese Biochemical Society. 64, 3, p. 172-177 6 p.

Research output: Contribution to journalReview article

Purinergic P2 Receptors
Purinergic Receptors
Catecholamines
Neurotransmitter Agents
Rats