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Research Output 1999 2019

  • 1073 Citations
  • 19 h-Index
  • 69 Article
  • 2 Review article
  • 1 Conference contribution
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Article
2019

2,5-Dimethylcelecoxib prevents isoprenaline-induced cardiomyocyte hypertrophy and cardiac fibroblast activation by inhibiting Akt-mediated GSK-3 phosphorylation

Morishige, S., Takahashi-Yanaga, F., Ishikane, S., arioka, M., Igawa, K., Kuroo, A., Tomooka, K., Shiose, A. & Sasaguri, T., Oct 1 2019, In : Biochemical Pharmacology. 168, p. 82-90 9 p.

Research output: Contribution to journalArticle

Glycogen Synthase Kinase 3
Phosphorylation
Cardiomegaly
Fibroblasts
Isoproterenol
1 Citation (Scopus)

Alkylthio- and alkyl-substituted asymmetric diphenyldiacetylene-based liquid crystals: phase transitions, mesophase and single-crystal structures, and birefringence

Arakawa, Y., Inui, S., Igawa, K. & Tsuji, H., Sep 2 2019, In : Liquid Crystals. 46, 11, p. 1621-1630 10 p.

Research output: Contribution to journalArticle

Liquid Crystals
Birefringence
Liquid crystals
birefringence
Bearings (structural)
1 Citation (Scopus)

Catalytic methane oxidation by a supramolecular conjugate based on a μ-nitrido-bridged iron porphyrinoid dimer

Yamada, Y., Morita, K., Mihara, N., Igawa, K., Tomooka, K. & Tanaka, K., Jan 1 2019, In : New Journal of Chemistry. 43, 29, p. 11477-11482 6 p.

Research output: Contribution to journalArticle

Rotaxanes
Porphyrins
Methane
Dimers
Iron
5 Citations (Scopus)

Site-Selective Supramolecular Complexation Activates Catalytic Ethane Oxidation by a Nitrido-Bridged Iron Porphyrinoid Dimer

Mihara, N., Yamada, Y., Takaya, H., Kitagawa, Y., Igawa, K., Tomooka, K., Fujii, H. & Tanaka, K., Mar 1 2019, In : Chemistry - A European Journal. 25, 13, p. 3369-3375 7 p.

Research output: Contribution to journalArticle

Ethane
Complexation
Dimers
Iron
Oxidation

Synthesis and stereochemical analysis of dynamic planar chiral nine-membered diallylic amide: Significant substituent effect on stereochemical stability

Hayashi, J. I., Uehara, K., Ano, Y., Kawasaki, Y., Igawa, K. & Tomooka, K., Jan 1 2019, In : Heterocycles. 99, 2, p. 856-864 9 p.

Research output: Contribution to journalArticle

Open Access
Stereochemistry
Enantiomers
Chirality
X ray analysis
Amides

Synthesis of fluorescent polycarbonates with highly twisted: N, N -bis(dialkylamino)anthracene AIE luminogens in the main chain

Sairi, A. S., Kuwahara, K., Sasaki, S., Suzuki, S., Igawa, K., Tokita, M., Ando, S., Morokuma, K., Suenobu, T. & Konishi, G. I., Jan 1 2019, In : RSC Advances. 9, 38, p. 21733-21740 8 p.

Research output: Contribution to journalArticle

Open Access
polycarbonate
Anthracene
Polycarbonates
Monomers
Carbonates

Synthesis of NMs-DACN: Small and hydrophilic click reaction device

Kawasaki, Y., Yamanaka, Y., Seto, Y., Igawa, K. & Tomooka, K., Jan 1 2019, In : Chemistry Letters. 48, 5, p. 495-497 3 p.

Research output: Contribution to journalArticle

Azides
Copper
Solubility
Water
2018
10 Citations (Scopus)

Asymmetric Synthesis of Axially Chiral Benzocarbazole Derivatives Based on Catalytic Enantioselective Hydroarylation of Alkynes

Arae, S., Beppu, S., Kawatsu, T., Igawa, K., Tomooka, K. & Irie, R., Aug 17 2018, In : Organic Letters. 20, 16, p. 4796-4800 5 p.

Research output: Contribution to journalArticle

Alkynes
indoles
alkynes
Derivatives
Reaction intermediates
2 Citations (Scopus)
Silica Gel
Alkenes
Isomerization
Isomers
Molecules
2 Citations (Scopus)

Internal-Edge-Substituted Coumarin-Fused [6]Helicenes: Asymmetric Synthesis, Structural Features, and Control of Self-Assembly

Usui, K., Yamamoto, K., Ueno, Y., Igawa, K., Hagihara, R., Masuda, T., Ojida, A., Karasawa, S., Tomooka, K., Hirai, G. & Suemune, H., Oct 1 2018, In : Chemistry - A European Journal. 24, 55, p. 14617-14621 5 p.

Research output: Contribution to journalArticle

Self assembly
X ray crystallography
Quantum yield
Electronic structure
Physical properties
3 Citations (Scopus)

KI–Tetraethylene Glycol Complex as an Effective Catalyst for the Synthesis of Cyclic Thiocarbonates from Epoxides and CS2

Okada, M., Nishiyori, R., Kaneko, S., Igawa, K. & Shirakawa, S., May 8 2018, In : European Journal of Organic Chemistry. 2018, 17, p. 2022-2027 6 p.

Research output: Contribution to journalArticle

Glycols
epoxy compounds
Epoxy Compounds
glycols
catalysts
9 Citations (Scopus)

Transient Protection of Organic Azides from Click Reactions with Alkynes by Phosphazide Formation

Meguro, T., Yoshida, S., Igawa, K., Tomooka, K. & Hosoya, T., Jul 6 2018, In : Organic Letters. 20, 13, p. 4126-4130 5 p.

Research output: Contribution to journalArticle

azides (organic)
Alkynes
Azides
alkynes
sulfur
1 Citation (Scopus)

Vinylidene ortho-quinone methides: Unique chiral reaction intermediates in catalytic asymmetric synthesis

Arae, S., Furusawa, M., Beppu, S., Igawa, K., Tomooka, K. & Irie, R., Jan 1 2018, In : Chimia. 72, 12, p. 892-899 8 p.

Research output: Contribution to journalArticle

Reaction intermediates
Benzopyrans
Benzofurans
Carbazoles
Indoles
2017
7 Citations (Scopus)

2,5-Dimethylcelecoxib prevents pressure-induced left ventricular remodeling through GSK-3 activation

Fujita, A., Takahashi-Yanaga, F., Morimoto, S., Yoshihara, T., arioka, M., Igawa, K., Tomooka, K., Hoka, S. & Sasaguri, T., Feb 1 2017, In : Hypertension Research. 40, 2, p. 130-139 10 p.

Research output: Contribution to journalArticle

Glycogen Synthase Kinase 3
Ventricular Remodeling
Pressure
Constriction
Heart Failure
5 Citations (Scopus)
Glycogen Synthase Kinase 3
Cell proliferation
Cell Movement
Tumors
Melanoma
12 Citations (Scopus)

Celecoxib and 2,5-dimethylcelecoxib inhibit intestinal cancer growth by suppressing the Wnt/β-catenin signaling pathway

Egashira, I., Takahashi-Yanaga, F., Nishida, R., arioka, M., Igawa, K., Tomooka, K., Nakatsu, Y., Tsuzuki, T., Nakabeppu, Y., Kitazono, T. & Sasaguri, T., Jan 1 2017, In : Cancer Science. 108, 1, p. 108-115 8 p.

Research output: Contribution to journalArticle

Celecoxib
Intestinal Neoplasms
Catenins
Wnt Signaling Pathway
Growth
14 Citations (Scopus)

Construction of Condensed Polycyclic Aromatic Frameworks through Intramolecular Cycloaddition Reactions Involving Arynes Bearing an Internal Alkyne Moiety

Yoshida, S., Shimizu, K., Uchida, K., Hazama, Y., Igawa, K., Tomooka, K. & Hosoya, T., Nov 2 2017, In : Chemistry - A European Journal. 23, 61, p. 15332-15335 4 p.

Research output: Contribution to journalArticle

Bearings (structural)
Alkynes
Cycloaddition
Derivatives
Aromatic compounds
11 Citations (Scopus)

Hydrogen bonding liquid crystalline benzoic acids with alkylthio groups: Phase transition behavior and insights into the cybotactic nematic phase

Arakawa, Y., Sasaki, Y., Igawa, K. & Tsuji, H., 2017, In : New Journal of Chemistry. 41, 14, p. 6514-6522 9 p.

Research output: Contribution to journalArticle

Benzoic acid
Benzoates
Superconducting transition temperature
Hydrogen bonds
Phase transitions
12 Citations (Scopus)

Oxygen Reduction to Water by a Cofacial Dimer of Iron(III)–Porphyrin and Iron(III)–Phthalocyanine Linked through a Highly Flexible Fourfold Rotaxane

Mihara, N., Yamada, Y., Takaya, H., Kitagawa, Y., Aoyama, S., Igawa, K., Tomooka, K. & Tanaka, K., Jan 1 2017, In : Chemistry - A European Journal. 23, 31, p. 7508-7514 7 p.

Research output: Contribution to journalArticle

Rotaxanes
Porphyrins
Dimers
Iron
Oxygen
8 Citations (Scopus)

Stereoselective Intramolecular Dearomatizative [4+2] Cycloaddition of Linked Ethynylnaphthol–Benzofuran Systems

Beppu, S., Arae, S., Furusawa, M., Arita, K., Fujimoto, H., Sumimoto, M., Imahori, T., Igawa, K., Tomooka, K. & Irie, R., Dec 15 2017, In : European Journal of Organic Chemistry. 2017, 46, p. 6914-6918 5 p.

Research output: Contribution to journalArticle

Cycloaddition
furans
cycloaddition
quinones
vinylidene
6 Citations (Scopus)

Synthesis and stereochemical properties of chiral hetero[7]helicenes structured by a benzodiheterole ring core

Arae, S., Mori, T., Kawatsu, T., Ueda, D., Shigeta, Y., Hamamoto, N., Fujimoto, H., Sumimoto, M., Imahori, T., Igawa, K., Tomooka, K., Punniyamurthy, T. & Irie, R., Jan 1 2017, In : Chemistry Letters. 46, 8, p. 1214-1216 3 p.

Research output: Contribution to journalArticle

Pyrroles
Chemical stability
Discrete Fourier transforms
Kinetics
Temperature
4 Citations (Scopus)

Synthesis of Stereoselectively Functionalized Silacyclopentanes

Igawa, K., Kuroo, A., Yoshihiro, D., Yamanaka, Y. & Tomooka, K., Nov 13 2017, In : Synlett. 28, 18, p. 2445-2448 4 p.

Research output: Contribution to journalArticle

Silicon
Carboxylic Acids
Amines
Substitution reactions
Carbon
11 Citations (Scopus)

The K-Region in Pyrenes as a Key Position to Activate Aggregation-Induced Emission: Effects of Introducing Highly Twisted N,N-Dimethylamines

Sasaki, S., Suzuki, S., Igawa, K., Morokuma, K. & Konishi, G. I., Jul 7 2017, In : Journal of Organic Chemistry. 82, 13, p. 6865-6873 9 p.

Research output: Contribution to journalArticle

Dimethylamines
Pyrenes
Agglomeration
Fluorescence
Quantum yield
6 Citations (Scopus)

Thieme Chemistry Journals Awardees: Where Are They Now? One-Pot Synthesis of Versatile Buckle Units for Click Chemistry: 4,8-Diazacyclononynes (DACNs)

Igawa, K., Aoyama, S., Kawasaki, Y., Kashiwagi, T., Seto, Y., Ni, R., Mitsuda, N. & Tomooka, K., Jan 1 2017, In : Synlett. 28, 16, p. 2110-2114 5 p.

Research output: Contribution to journalArticle

Copper
2-butyne-1,4-diol
2016
6 Citations (Scopus)

Aryl-Allene Cyclization via a Hg(OTf)2-Catalytic Pathway

Yamamoto, H., Ueda, M., Yamasaki, N., Fujii, A., Sasaki, I., Igawa, K., Kasai, Y., Imagawa, H. & Nishizawa, M., Jun 17 2016, In : Organic Letters. 18, 12, p. 2864-2867 4 p.

Research output: Contribution to journalArticle

Cyclization
Mercury
Deuterium
Labeling
marking
15 Citations (Scopus)

Enantioselective Synthesis of Silacyclopentanes

Igawa, K., Yoshihiro, D., Abe, Y. & Tomooka, K., May 4 2016, In : Angewandte Chemie - International Edition. 55, 19, p. 5814-5818 5 p.

Research output: Contribution to journalArticle

Serotonin Receptors
Discrete Fourier transforms
Oxides
Assays
Proteins
46 Citations (Scopus)

Highly Twisted N,N-Dialkylamines as a Design Strategy to Tune Simple Aromatic Hydrocarbons as Steric Environment-Sensitive Fluorophores

Sasaki, S., Suzuki, S., Sameera, W. M. C., Igawa, K., Morokuma, K. & Konishi, G. I., Jul 6 2016, In : Journal of the American Chemical Society. 138, 26, p. 8194-8206 13 p.

Research output: Contribution to journalArticle

Anthracenes
Aromatic Hydrocarbons
Fluorophores
Anthracene
Aromatic hydrocarbons
17 Citations (Scopus)

Rational Design and Synthesis of [5]Helicene-Derived Phosphine Ligands and Their Application in Pd-Catalyzed Asymmetric Reactions

Yamamoto, K., Shimizu, T., Igawa, K., Tomooka, K., Hirai, G., Suemune, H. & Usui, K., Nov 8 2016, In : Scientific reports. 6, 36211.

Research output: Contribution to journalArticle

phosphine
Ligands
Indoles
Acetates
Alcohols
5 Citations (Scopus)

Synthesis and Stereochemical Analysis of Planar-Chiral (E)-4-[7]Orthocyclophene

Igawa, K., Machida, K., Noguchi, K., Uehara, K. & Tomooka, K., Dec 2 2016, In : Journal of Organic Chemistry. 81, 23, p. 11587-11593 7 p.

Research output: Contribution to journalArticle

Chirality
Isomerization
Lewis Acids
Oxidation
Sulfones
19 Citations (Scopus)

Thiazolobenzyne: A versatile intermediate for multisubstituted benzothiazoles

Yoshida, S., Yano, T., Nishiyama, Y., Misawa, Y., Kondo, M., Matsushita, T., Igawa, K., Tomooka, K. & Hosoya, T., Jan 1 2016, In : Chemical Communications. 52, 75, p. 11199-11202 4 p.

Research output: Contribution to journalArticle

Benzothiazoles
Thiazoles
Iodine
Magnesium
benzyne
2015
9 Citations (Scopus)

Catalytic Enantioselective Synthesis of Planar-Chiral Cyclic Amides Based on a Pd-Catalyzed Asymmetric Allylic Substitution Reaction

Igawa, K., Ichikawa, N., Ano, Y., Katanoda, K., Ito, M., Akiyama, T. & Tomooka, K., Jun 17 2015, In : Journal of the American Chemical Society. 137, 23, p. 7294-7297 4 p.

Research output: Contribution to journalArticle

Cyclization
Amides
Substitution reactions
Ligands
8 Citations (Scopus)

Differentiation-inducing factor-3 inhibits intestinal tumor growth in vitro and in vivo

Kubokura, N., Takahashi, F., arioka, M., Yoshihara, T., Igawa, K., Tomooka, K., Morimoto, S., Nakatsu, Y., Tsuzuki, T., Nakabeppu, Y., Matsumoto, T., Kitazono, T. & Sasaguri, T., Jan 1 2015, In : Journal of Pharmacological Sciences. 127, 4, p. 446-455 10 p.

Research output: Contribution to journalArticle

Growth
Neoplasms
Intestinal Neoplasms
Catenins
Dictyostelium
25 Citations (Scopus)

Directional control of π-conjugation enabled by distortion of the donor plane in diarylaminoanthracenes: A photophysical study

Sasaki, S., Hattori, K., Igawa, K. & Konishi, G. I., May 21 2015, In : Journal of Physical Chemistry A. 119, 20, p. 4898-4906 9 p.

Research output: Contribution to journalArticle

directional control
conjugation
Fluorescence
anthracene
methylene
61 Citations (Scopus)

Direct Thioamination of Arynes via Reaction with Sulfilimines and Migratory N-Arylation

Yoshida, S., Yano, T., Misawa, Y., Sugimura, Y., Igawa, K., Shimizu, S., Tomooka, K. & Hosoya, T., Nov 11 2015, In : Journal of the American Chemical Society. 137, 44, p. 14071-14074 4 p.

Research output: Contribution to journalArticle

sulfilimine
43 Citations (Scopus)

Heteroatom-embedded medium-sized cycloalkynes: Concise synthesis, structural analysis, and reactions

Ni, R., Mitsuda, N., Kashiwagi, T., Igawa, K. & Tomooka, K., Jan 19 2015, In : Angewandte Chemie - International Edition. 54, 4, p. 1190-1194 5 p.

Research output: Contribution to journalArticle

Cycloparaffins
Alkynes
Cycloaddition
Structural analysis
Peptides

Synthesis, stereochemical characteristics, and coordination behavior of 2,2'-binaphthyl-1,1'-biisoquinoline as a new axially chiral bidentate ligand

Kawatsu, T., Tokushima, H., Takedomi, Y., Imahori, T., Igawa, K., Tomooka, K. & Irie, R., Jul 6 2015, In : Arkivoc. 2015, 4, p. 161-175 15 p.

Research output: Contribution to journalArticle

Ligands
Stereoisomerism
Chloroform
Temperature
X ray diffraction analysis
1 Citation (Scopus)

Synthesis and structural analysis of nine-membered enyne nitrogen heterocycles

Igawa, K., Kawabata, T., Uehara, K. & Tomooka, K., Jan 1 2015, In : Heterocycles. 90, 2, p. 901-906 6 p.

Research output: Contribution to journalArticle

Alkynes
Chirality
X ray analysis
Alkenes
Structural analysis
31 Citations (Scopus)

The effect of regioisomerism on the solid-state fluorescence of bis(piperidyl)anthracenes: Structurally simple but bright AIE luminogens

Sasaki, S., Igawa, K. & Konishi, G. I., Jun 21 2015, In : Journal of Materials Chemistry C. 3, 23, p. 5940-5950 11 p.

Research output: Contribution to journalArticle

Anthracenes
Anthracene
Agglomeration
Fluorescence
Discrete Fourier transforms
2014
18 Citations (Scopus)

Aggregation-induced emission active D-π-A binaphthyl luminophore with dual-mode fluorescence

Sasaki, S., Niko, Y., Igawa, K. & Konishi, G. I., Jan 1 2014, In : RSC Advances. 4, 63, p. 33474-33477 4 p.

Research output: Contribution to journalArticle

Coloring Agents
Agglomeration
Dyes
Fluorescence
Chromophores
43 Citations (Scopus)

An efficient generation method and remarkable reactivities of 3-triflyloxybenzyne

Yoshida, S., Uchida, K., Igawa, K., Tomooka, K. & Hosoya, T., Dec 11 2014, In : Chemical Communications. 50, 95, p. 15059-15062 4 p.

Research output: Contribution to journalArticle

Nucleophiles
Iodine
Magnesium
iodobenzene
3 Citations (Scopus)

Asymmetric ozone oxidation of silylalkenes using a C2- symmetrical dialkoxysilyl group as a chiral auxiliary

Igawa, K., Kawasaki, Y., Nishino, K., Mitsuda, N. & Tomooka, K., Jul 21 2014, In : Chemistry - A European Journal. 20, 30, p. 9255-9258 4 p.

Research output: Contribution to journalArticle

Ozone
Oxidation
Alkynes
Carbonyl compounds
Alkenes
15 Citations (Scopus)

DIF-1 inhibits tumor growth in vivo reducing phosphorylation of GSK-3β and expressions of cyclin D1 and TCF7L2 in cancer model mice

Takahashi, F., Yoshihara, T., Jingushi, K., Igawa, K., Tomooka, K., Watanabe, Y., Morimoto, S., Nakatsu, Y., Tsuzuki, T., Nakabeppu, Y. & Sasaguri, T., Jun 1 2014, In : Biochemical Pharmacology. 89, 3, p. 340-348 9 p.

Research output: Contribution to journalArticle

T Cell Transcription Factor 1
Glycogen Synthase Kinase 3
Phosphorylation
Cyclin D1
Tumors
2 Citations (Scopus)
Cyclization
Benzofurans
Benzopyrans
Heterocyclic Compounds
Benzene
9 Citations (Scopus)

Planar chiral dialkoxysilane: Introduction of inherent chirality and high reactivity in conventional achiral alkene

Tomooka, K., Miyasaka, S., Motomura, S. & Igawa, K., Jun 16 2014, In : Chemistry - A European Journal. 20, 25, p. 7598-7602 5 p.

Research output: Contribution to journalArticle

Epoxidation
Azides
Cycloaddition
Chirality
Alkenes
2013
20 Citations (Scopus)

Base-catalyzed Schmittel cycloisomerization of o-phenylenediyne-linked bis(arenol)s to indeno[1,2-c]chromenes

Furusawa, M., Arita, K., Imahori, T., Igawa, K., Tomooka, K. & Irie, R., Dec 25 2013, In : Tetrahedron Letters. 54, 52, p. 7107-7110 4 p.

Research output: Contribution to journalArticle

Benzopyrans
Cycloaddition
Cycloaddition Reaction
Transition metals
Metals
9 Citations (Scopus)

Oxidation of silanes to silanols on Pd nanoparticles: H2 desorption accelerated by surface oxygen atom

Kamachi, T., Shimizu, K. I., Yoshihiro, D., Igawa, K., Tomooka, K. & Yoshizawa, K., Nov 7 2013, In : Journal of Physical Chemistry C. 117, 44, p. 22967-22973 7 p.

Research output: Contribution to journalArticle

Silanes
silanes
oxygen atoms
Desorption
desorption
14 Citations (Scopus)

Palladium-catalyzed tandem cyclodehydrogenation of o-phenylenediyne-linked bis(arenol)s to produce benzodifuran-containing condensed heteroaromatic ring systems

Furusawa, M., Imahori, T., Igawa, K., Tomooka, K. & Irie, R., Oct 16 2013, In : Chemistry Letters. 42, 10, p. 1134-1136 3 p.

Research output: Contribution to journalArticle

Palladium
Water
Hysteresis loops
Freezing
Dielectric properties
50 Citations (Scopus)

Preparation and investigation of the formation mechanism of submicron-sized spherical particles of gold using laser ablation and laser irradiation in liquids

Tsuji, T., Yahata, T., Yasutomo, M., Igawa, K., Tsuji, M., Ishikawa, Y. & Koshizaki, N., Mar 7 2013, In : Physical Chemistry Chemical Physics. 15, 9, p. 3099-3107 9 p.

Research output: Contribution to journalArticle

Laser ablation
Laser beam effects
Gold
laser ablation
gold
4 Citations (Scopus)

Synthesis, structural analysis, and reaction of 3-Aza-5-[7]orthocyclophyne

Igawa, K., Kawabata, T., Ni, R. & Tomooka, K., Nov 11 2013, In : Chemistry Letters. 42, 11, p. 1374-1376 3 p.

Research output: Contribution to journalArticle

Chirality
Structural analysis
Halogenation
Temperature
2012
39 Citations (Scopus)

Catalytic enantioselective synthesis of alkenylhydrosilanes

Igawa, K., Yoshihiro, D., Ichikawa, N., Kokan, N. & Tomooka, K., Dec 14 2012, In : Angewandte Chemie - International Edition. 51, 51, p. 12745-12748 4 p.

Research output: Contribution to journalArticle

Silanes
Alkenylation
Alkynes
Hydrides
Catalysts