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Research Output 1989 2019

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Review article
2019
1 Citation (Scopus)

Potentials of C-C motif chemokine 2–C-C chemokine receptor type 2 blockers including propagermanium as anticancer agents

Yumimoto, K., Sugiyama, S., Mimori, K. & Nakayama, K. I., Jul 2019, In : Cancer Science. 110, 7, p. 2090-2099 10 p.

Research output: Contribution to journalReview article

Open Access
C Chemokines
CC Chemokines
Chemokine Receptors
Antineoplastic Agents
Inflammation
2018
5 Citations (Scopus)

The promise of targeted proteomics for quantitative network biology

Matsumoto, M. & Nakayama, K., Dec 1 2018, In : Current Opinion in Biotechnology. 54, p. 88-97 10 p.

Research output: Contribution to journalReview article

Proteomics
Proteins
Assays
Biological Phenomena
Recombinant proteins
2016
35 Citations (Scopus)

To wake up cancer stem cells, or to let them sleep, that is the question

Takeishi, S. & Nakayama, K. I., Jul 1 2016, In : Cancer Science. 107, 7, p. 875-881 7 p.

Research output: Contribution to journalReview article

Neoplastic Stem Cells
Sleep
Cell Cycle
Stem Cell Niche
Therapeutics
2014
33 Citations (Scopus)

Role of Fbxw7 in the maintenance of normal stem cells and cancer-initiating cells.

Takeishi, S. & Nakayama, K. I., Sep 9 2014, In : British journal of cancer. 111, 6, p. 1054-1059 6 p.

Research output: Contribution to journalReview article

Neoplastic Stem Cells
Maintenance
Cell Cycle
Stem Cells
Neoplasms
2013
3 Citations (Scopus)

Integrated view of the human chromosome x-centric proteome project

Yamamoto, T., Nakayama, K., Hirano, H., Tomonaga, T., Ishihama, Y., Yamada, T., Kondo, T., Kodera, Y., Sato, Y., Araki, N., Mamitsuka, H. & Goshima, N., Jan 4 2013, In : Journal of Proteome Research. 12, 1, p. 58-61 4 p.

Research output: Contribution to journalReview article

Human Chromosomes
X Chromosome
Proteome
Chromosomes
Antibodies
21 Citations (Scopus)

Role of key regulators of the cell cycle in maintenance of hematopoietic stem cells

Matsumoto, A. & Nakayama, K., Feb 1 2013, In : Biochimica et Biophysica Acta - General Subjects. 1830, 2, p. 2335-2344 10 p.

Research output: Contribution to journalReview article

Hematopoietic Stem Cells
Stem cells
Cell Cycle
Cells
Maintenance
2012
1 Citation (Scopus)

Comprehensive study of protein ubiquitylation sites by conjugation of engineered lysine-less ubiquitin

Oshikawa, K., Matsumoto, M. & Nakayama, K., Dec 1 2012, In : Seikagaku. 84, 6, p. 479-487 9 p.

Research output: Contribution to journalReview article

Ubiquitination
Ubiquitin
Lysine
Proteins
2009
8 Citations (Scopus)

Functional similarities and uniqueness of p27 and p57: Insight from a knock-in mouse model

Susaki, E. & Nakayama, K., Aug 15 2009, In : Cell Cycle. 8, 16, p. 2497-2501 5 p.

Research output: Contribution to journalReview article

Cyclin-Dependent Kinases
Cyclin-Dependent Kinase Inhibitor p57
Cyclin-Dependent Kinase Inhibitor p27
Genes
Phenotype
2008
28 Citations (Scopus)

Fbxw7 in cell cycle exit and stem cell maintenance: Insight from gene-targeted mice

Onoyama, I. & Nakayama, K., Nov 1 2008, In : Cell Cycle. 7, 21, p. 3307-3313 7 p.

Research output: Contribution to journalReview article

Cell Cycle
Stem Cells
Maintenance
Genes
SKP Cullin F-Box Protein Ligases
2 Citations (Scopus)
F-Box Proteins
Proto-Oncogene Proteins c-myc
Tumor Suppressor Protein p53
Cell Cycle Resting Phase
Cell Cycle Proteins

Regulation of cell proliferation and tumorigenesis by ubiquitin-proteasome pathway

Matsumoto, A. & Nakayama, K., Nov 1 2008, In : Biotherapy. 22, 6, p. 363-370 8 p.

Research output: Contribution to journalReview article

Proteasome Endopeptidase Complex
Ubiquitin
Cell Cycle
Carcinogenesis
Cell Proliferation
2007
38 Citations (Scopus)

Multiple mechanisms for p27Kip1 translocation and degradation

Susaki, E. & Nakayama, K., Dec 15 2007, In : Cell Cycle. 6, 24, p. 3015-3020 6 p.

Research output: Contribution to journalReview article

Cyclin D2
Cell Nucleus Active Transport
Cyclin-Dependent Kinases
Growth
Cell Cycle
2006
912 Citations (Scopus)

Ubiquitin ligases: Cell-cycle control and cancer

Nakayama, K. & Nakayama, K., May 1 2006, In : Nature Reviews Cancer. 6, 5, p. 369-381 13 p.

Research output: Contribution to journalReview article

Ubiquitination
Ligases
Ubiquitin
Cell Cycle Checkpoints
Cell Cycle
2 Citations (Scopus)

Ubiquitin system regulating G1 and S phases of cell cycle

Nakayama, K. & Nakayama, K., Aug 1 2006, In : Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme.. 51, 10 Suppl, p. 1362-1369 8 p.

Research output: Contribution to journalReview article

Ubiquitin-Protein Ligase Complexes
Cyclin-Dependent Kinase Inhibitor Proteins
Cell Cycle Proteins
Cyclin-Dependent Kinases
G1 Phase
2005
8 Citations (Scopus)

Mapping of ubiquitination sites on target proteins

Hatakeyama, S., Matsumoto, M. & Nakayama, K., Jan 1 2005, In : Methods in enzymology. 399, p. 277-286 10 p., 19.

Research output: Contribution to journalReview article

Ubiquitinated Proteins
Ubiquitination
Lysine
Mass Spectrometry
Polyubiquitin
256 Citations (Scopus)

Regulation of the cell cycle by SCF-type ubiquitin ligases

Nakayama, K. & Nakayama, K., Jan 1 2005, In : Seminars in Cell and Developmental Biology. 16, 3, p. 323-333 11 p.

Research output: Contribution to journalReview article

SKP Cullin F-Box Protein Ligases
Cell Cycle
F-Box Proteins
Ubiquitin
Proteolysis
3 Citations (Scopus)

The degradation of p27 and cancer

Kotoshiba, S. & Nakayama, K., Jan 1 2005, In : Nippon rinsho. Japanese journal of clinical medicine. 63, 11, p. 2047-2056 10 p.

Research output: Contribution to journalReview article

Cyclin-Dependent Kinases
Cell Cycle
Cell Cycle Resting Phase
Cyclins
Ubiquitination
2004
5 Citations (Scopus)
Immunophilins
Mitochondria
Apoptosis
Tacrolimus Binding Protein 1A
Apoptosis Regulatory Proteins
2003

Deregulated Proteolysis of the Cell Cycle Regulator p27Kip1 and Cancers

Susaki, E. & Nakayama, K., Nov 2003, In : Biotherapy. 17, 6, p. 546-555 10 p.

Research output: Contribution to journalReview article

Proteolysis
Cell Cycle
Neoplasms
Ubiquitin
S-Phase Kinase-Associated Proteins
217 Citations (Scopus)

Inherent calcineurin inhibitor FKBP38 targets Bcl-2 to mitochondria and inhibits apoptosis

Shirane, M. & Nakayama, K., Jan 1 2003, In : Nature Cell Biology. 5, 1, p. 28-37 10 p.

Research output: Contribution to journalReview article

Tacrolimus Binding Proteins
Mitochondria
Apoptosis
Tacrolimus Binding Protein 1A
Calcineurin
2 Citations (Scopus)

Proliferative regulation in the cornea and lens

Yoshida, K., Harada, T., Harada, C., Kase, S., Ikeda, H., Sakai, M., Nishi, S., Imaki, J., Nakayama, K., Nagahama, H., Nakayama, K. & Ohno, S., Jan 1 2003, In : Nippon Ganka Gakkai zasshi. 107, 11, p. 678-686 9 p.

Research output: Contribution to journalReview article

Cornea
Lenses
Bromodeoxyuridine
Corneal Epithelium
Immunohistochemistry
43 Citations (Scopus)

Ubiquitylation as a quality control system for intracellular proteins

Hatakeyama, S. & Nakayama, K. I., Jul 1 2003, In : Journal of biochemistry. 134, 1, p. 1-8 8 p.

Research output: Contribution to journalReview article

Ubiquitination
Quality Control
Quality control
Control systems
Ubiquitin
149 Citations (Scopus)

U-box proteins as a new family of ubiquitin ligases

Hatakeyama, S. & Nakayama, K., Mar 21 2003, In : Biochemical and Biophysical Research Communications. 302, 4, p. 635-645 11 p.

Research output: Contribution to journalReview article

Ligases
Ubiquitin
Fungal Proteins
Fingers
Proteins
2001
189 Citations (Scopus)

Regulation of the cell cycle at the G1-S transition by proteolysis of cyclin E and p27Kip1

Nakayama, K., Hatakeyama, S. & Nakayama, K., Jan 1 2001, In : Biochemical and Biophysical Research Communications. 282, 4, p. 853-860 8 p.

Research output: Contribution to journalReview article

Proteolysis
Cyclin E
Cell Cycle
Cells
Ubiquitin
1998
169 Citations (Scopus)

Cip/Kip cyclin-dependent kinase inhibitors: Brakes of the cell cycle engine during development

Nakayama, K. & Nakayama, K., Jan 1 1998, In : BioEssays. 20, 12, p. 1020-1029 10 p.

Research output: Contribution to journalReview article

Cyclin-Dependent Kinases
Brakes
Cell Cycle
Cells
Engines