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Research Output 2012 2019

  • 599 Citations
  • 8 h-Index
  • 13 Article
  • 1 Letter
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Article
2019

Genetic Profiling of Non-Small Cell Lung Cancer at Development of Resistance to First- or Second-Generation EGFR-TKIs by CAPP-Seq Analysis of Circulating Tumor DNA

Otsubo, K., Sakai, K., Takeshita, M., Harada, D., Azuma, K., ota, K., Akamatsu, H., Goto, K., Horiike, A., Kurata, T., Nakagaki, N., Nosaki, K., Iwama, E., Nakanishi, Y., Nishio, K. & Okamoto, I., Jan 1 2019, In : Oncologist. 24, 8, p. 1022-1026 5 p.

Research output: Contribution to journalArticle

High-Throughput Nucleotide Sequencing
Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
Protein-Tyrosine Kinases
DNA
2018

Detection of identical T cell clones in peritumoral pleural effusion and pneumonitis lesions in a cancer patient during immune-checkpoint blockade

Tanaka, K., Yanagihara, T., Ikematsu, Y., Inoue, H., ota, K., Kashiwagi, E., Suzuki, K., Hamada, N., takeuchi, A., Tatsugami, K., Eto, M., Ijichi, K., Oda, Y., Otsubo, K., Yoneshima, Y., Iwama, E., Nakanishi, Y. & Okamoto, I., Jul 17 2018, In : Oncotarget. 9, 55, p. 30587-30593 7 p.

Research output: Contribution to journalArticle

Bronchoalveolar Lavage Fluid
Pleural Effusion
Pneumonia
Clone Cells
T-Cell Antigen Receptor
5 Citations (Scopus)

Intrinsic and Extrinsic Regulation of PD-L2 Expression in Oncogene-Driven Non–Small Cell Lung Cancer

Shibahara, D., Tanaka, K., Iwama, E., Kubo, N., ota, K., Azuma, K., Harada, T., Fujita, J., Nakanishi, Y. & Okamoto, I., Jul 1 2018, In : Journal of Thoracic Oncology. 13, 7, p. 926-937 12 p.

Research output: Contribution to journalArticle

Oncogenes
Non-Small Cell Lung Carcinoma
Cell Death
Ligands
STAT3 Transcription Factor
11 Citations (Scopus)

PD-L1 expression in lung adenocarcinoma harboring EGFR mutations or ALK rearrangements

Yoneshima, Y., Ijichi, K., Anai, S., ota, K., Otsubo, K., Iwama, E., Tanaka, K., Oda, Y., Nakanishi, Y. & Okamoto, I., Apr 1 2018, In : Lung Cancer. 118, p. 36-40 5 p.

Research output: Contribution to journalArticle

Mutation
Neoplasms
Adenocarcinoma of lung
Protein-Tyrosine Kinases
Oncogenes
2017

Interleukin-22 attenuates double-stranded RNA-induced upregulation of PD-L1 in airway epithelial cells via a STAT3-dependent mechanism

Seki, N., Kan-o, K., Matsumoto, K., Fukuyama, S., Hamano, S., Tonai, K., ota, K., Inoue, H. & Nakanishi, Y., Dec 9 2017, In : Biochemical and Biophysical Research Communications. 494, 1-2, p. 242-248 7 p.

Research output: Contribution to journalArticle

Double-Stranded RNA
Up-Regulation
Epithelial Cells
Poly C
Viruses
2015
9 Citations (Scopus)

Hypermethylation of the CpG dinucleotide in epidermal growth factor receptor codon 790: Implications for a mutational hotspot leading to the T790M mutation in non-small-cell lung cancer

Fujii, A., Harada, T., Iwama, E., ota, K., Furuyama, K., Ijichi, K., Okamoto, T., Okamoto, I., Takayama, K. & Nakanishi, Y., May 1 2015, In : Cancer Genetics. 208, 5, p. 271-278 8 p.

Research output: Contribution to journalArticle

5-Methylcytosine
Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
Codon
Mutation
205 Citations (Scopus)

Induction of PD-L1 expression by the EML4-ALK oncoprotein and down stream signaling pathways in non-small cell lung cancer

ota, K., Azuma, K., Kawahara, A., Hattori, S., Iwama, E., Tanizaki, J., Harada, T., Matsumoto, K., Takayama, K., Takamori, S., Kage, M., Hoshino, T., Nakanishi, Y. & Okamoto, I., Sep 1 2015, In : Clinical Cancer Research. 21, 17, p. 4014-4021 8 p.

Research output: Contribution to journalArticle

Oncogene Proteins
Non-Small Cell Lung Carcinoma
Gene Fusion
Phosphatidylinositol 3-Kinases
Cell Line
17 Citations (Scopus)

Nicotine induces resistance to erlotinib via cross-talk between α 1 nAChR and EGFR in the non-small cell lung cancer xenograft model

Li, H., Wang, S., Takayama, K., Harada, T., Okamoto, I., Iwama, E., Fujii, A., ota, K., Hidaka, N., Kawano, Y. & Nakanishi, Y., Apr 1 2015, In : Lung Cancer. 88, 1, p. 1-8 8 p.

Research output: Contribution to journalArticle

Nicotinic Receptors
Nicotine
Heterografts
Non-Small Cell Lung Carcinoma
MAP Kinase Signaling System
2014
306 Citations (Scopus)

Association of PD-L1 overexpression with activating EGFR mutations in surgically resected nonsmall-cell lung cancer

Azuma, K., ota, K., Kawahara, A., Hattori, S., Iwama, E., Harada, T., Matsumoto, K., Takayama, K., Takamori, S., Kage, M., Hoshino, T., Nakanishi, Y. & Okamoto, I., Oct 1 2014, In : Annals of oncology : official journal of the European Society for Medical Oncology / ESMO. 25, 10, p. 1935-1940 6 p.

Research output: Contribution to journalArticle

erbB-1 Genes
Non-Small Cell Lung Carcinoma
Ligands
Mutation
Cell Line
10 Citations (Scopus)

PICT1 expression is a poor prognostic factor in non-small cell lung cancer

Okamura, K., Takayama, K., Kawahara, K., Harada, T., Nishio, M., Otsubo, K., Ijichi, K., Kohno, M., Iwama, E., Fujii, A., ota, K., Koga, T., Okamoto, T., Suzuki, A. & Nakanishi, Y., Jan 1 2014, In : Oncoscience. 1, 5, p. 375-382 8 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Neoplasms
Cytoplasm
Multivariate Analysis
Smoking
2013
27 Citations (Scopus)

Sensitivity and kinase activity of epidermal growth factor receptor (EGFR) exon 19 and others to EGFR-tyrosine kinase inhibitors

Furuyama, K., Harada, T., Iwama, E., Shiraishi, Y., Okamura, K., Ijichi, K., Fujii, A., ota, K., Wang, S., Li, H., Takayama, K., Giaccone, G. & Nakanishi, Y., May 1 2013, In : Cancer Science. 104, 5, p. 584-589 6 p.

Research output: Contribution to journalArticle

Epidermal Growth Factor Receptor
Protein-Tyrosine Kinases
Exons
Mutation
Phosphotransferases
2012

A new cancer cell detection method using an infectivity-enhanced adenoviral vector

Uchino, J., Takayama, K., Nakagaki, N., Shuo, W., Hisasue, J., Nakatom, K., ota, K., Hirano, R., Tashiro, N., Miiru, I., Fujita, M., Watanabe, K. & Nakanishi, Y., Jan 1 2012, In : Asian Pacific Journal of Cancer Prevention. 13, 11, p. 5551-5556 6 p.

Research output: Contribution to journalArticle

Adenoviridae
Body Fluids
Neoplasms
Luciferases
Selection Bias
8 Citations (Scopus)

Efficacy of aprepitant in patients with advanced or recurrent lung cancer receiving moderately emetogenic chemotherapy

Uchino, J., Hirano, R., Tashiro, N., Yoshida, Y., Ushijima, S., Matsumoto, T., ota, K., Nakatomi, K., Takayama, K., Fujita, M., Nakanishi, Y. & Watanabe, K., Jan 1 2012, In : Asian Pacific Journal of Cancer Prevention. 13, 8, p. 4187-4190 4 p.

Research output: Contribution to journalArticle

aprepitant
Lung Neoplasms
Drug Therapy
Nausea
Serotonin 5-HT3 Receptor Antagonists