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Research Output 2005 2019

  • 566 Citations
  • 11 h-Index
  • 19 Article
  • 2 Review article
  • 1 Conference contribution
  • 1 Short survey
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Article
2019

Effects of insulin signaling on mouse taste cell proliferation

Takai, S., Watanabe, Y., Sanematsu, K., Yoshida, R., Margolskee, R. F., Jiang, P., Atsuta, I., Koyano, K., Ninomiya, Y. & Shigemura, N., Jan 1 2019, In : PloS one. 14, 11, e0225190.

Research output: Contribution to journalArticle

Open Access
Cell proliferation
Sirolimus
cell proliferation
insulin
Cell Proliferation

Expression of Renin-Angiotensin System Components in the Taste Organ of Mice

Shigemura, N., Takai, S., Hirose, F., Yoshida, R., Sanematsu, K. & Ninomiya, Y., Sep 19 2019, In : Nutrients. 11, 9

Research output: Contribution to journalArticle

Open Access
renin-angiotensin system
Renin-Angiotensin System
angiotensin II
mice
Angiotensin II
1 Citation (Scopus)

Structural architecture of a dimeric class C GPCR based on co-trafficking of sweet taste receptor subunits

Park, J., Selvam, B., Sanematsu, K., Shigemura, N., Shukla, D. & Procko, E., Jan 1 2019, In : Journal of Biological Chemistry. 294, 13, p. 4759-4774 16 p.

Research output: Contribution to journalArticle

G-Protein-Coupled Receptors
Dimerization
Dimers
Cysteine
Cells
2018
2 Citations (Scopus)

Bitter Taste Responses of Gustducin-positive Taste Cells in Mouse Fungiform and Circumvallate Papillae

Yoshida, R., Takai, S., Sanematsu, K., Margolskee, R. F., Shigemura, N. & Ninomiya, Y., Jan 15 2018, In : Neuroscience. 369, p. 29-39 11 p.

Research output: Contribution to journalArticle

Transient Receptor Potential Channels
Phospholipases
gustducin
Tongue
Phenylthiourea
2 Citations (Scopus)

Diurnal variation of sweet taste recognition thresholds is absent in overweight and obese humans

Sanematsu, K., Nakamura, Y., Nomura, M., Shigemura, N. & Ninomiya, Y., Mar 2 2018, In : Nutrients. 10, 3, 297.

Research output: Contribution to journalArticle

Taste Threshold
Leptin
leptin
diurnal variation
taste sensitivity
2016
8 Citations (Scopus)

Intracellular acidification is required for full activation of the sweet taste receptor by miraculin

Sanematsu, K., Kitagawa, M., Yoshida, R., Nirasawa, S., Shigemura, N. & Ninomiya, Y., Mar 10 2016, In : Scientific reports. 6, 22807.

Research output: Contribution to journalArticle

Acids
Citric Acid
Hydrochloric Acid
HEK293 Cells
Histidine
4 Citations (Scopus)

Leptin suppresses sweet taste responses of enteroendocrine STC-1 cells

Jyotaki, M., Sanematsu, K., Shigemura, N., Yoshida, R. & Ninomiya, Y., Sep 22 2016, In : Neuroscience. 332, p. 76-87 12 p.

Research output: Contribution to journalArticle

Leptin
Enteroendocrine Cells
KATP Channels
Hormones
Leptin Receptors
2014
32 Citations (Scopus)

Molecular mechanisms for sweet-suppressing effect of gymnemic acids

Sanematsu, K., Kusakabe, Y., Shigemura, N., Hirokawa, T., Nakamura, S., Imoto, T. & Ninomiya, Y., Sep 12 2014, In : Journal of Biological Chemistry. 289, 37, p. 25711-25720 10 p.

Research output: Contribution to journalArticle

HEK293 Cells
gymnemic acid
Glucuronic Acid
Mutagenesis
Triterpenes
15 Citations (Scopus)

Structure, function, and signaling of taste g-protein-coupled receptors

Sanematsu, K., Yoshida, R., Shigemura, N. & Ninomiya, Y., Jan 1 2014, In : Current Pharmaceutical Biotechnology. 15, 10, p. 951-961 11 p.

Research output: Contribution to journalArticle

Proteins
G-Protein-Coupled Receptors
Binding Sites
Molecular Evolution
Second Messenger Systems
2013
29 Citations (Scopus)

Angiotensin II modulates salty and sweet taste sensitivities

Shigemura, N., Iwata, S., Yasumatsu, K., Ohkuri, T., Horio, N., Sanematsu, K., Yoshida, R., Margolskee, R. F. & Ninomiya, Y., Apr 10 2013, In : Journal of Neuroscience. 33, 15, p. 6267-6277 11 p.

Research output: Contribution to journalArticle

Angiotensin II
Sweetening Agents
Amiloride
Sodium
Salts
2012
8 Citations (Scopus)

Nordihydroguaiaretic acid inhibition of NFATc1 suppresses osteoclastogenesis and arthritis bone destruction in rats

Li, Y. J., Kukita, A., Watanabe, T., Takano, T., Qu, P., Sanematsu, K., Ninomiya, Y. & Kukita, T., Dec 1 2012, In : Laboratory Investigation. 92, 12, p. 1777-1787 11 p.

Research output: Contribution to journalArticle

Masoprocol
Osteogenesis
Arthritis
Osteoclasts
Bone and Bones
2010
126 Citations (Scopus)

Endocannabinoids selectively enhance sweet taste

Yoshida, R., Ohkuri, T., Jyotaki, M., Yasuo, T., Horio, N., Yasumatsu, K., Sanematsu, K., Shigemura, N., Yamamoto, T., Margolskee, R. F. & Ninomiya, Y., Feb 15 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 2, p. 935-939 5 p.

Research output: Contribution to journalArticle

Endocannabinoids
Leptin
Cannabinoid Receptor CB1
Eating
Cannabinoid Receptor CB2
2009
8 Citations (Scopus)

Genetically-increased taste cell population with Gα-gustducin-coupled sweet receptors is associated with increase of gurmarin-sensitive taste nerve fibers in mice

Nakano, K., Ohkuri, T., Sanematsu, K., Shigemura, N., Katsukawa, H., Sako, N. & Ninomiya, Y., Dec 22 2009, In : BMC Neuroscience. 10, 152.

Research output: Contribution to journalArticle

Nerve Fibers
Population
Vulnerable Populations
gustducin
Gymnema sylvestre Gurmarin protein
59 Citations (Scopus)

Genetic and molecular basis of individual differences in human umami taste perception

Shigemura, N., Shirosaki, S., Sanematsu, K., Yoshida, R. & Ninomiya, Y., Aug 21 2009, In : PloS one. 4, 8, e6717.

Research output: Contribution to journalArticle

Taste Perception
umami
Sodium Glutamate
Individuality
Molecular Biology
51 Citations (Scopus)

Variation in umami perception and in candidate genes for the umami receptor in mice and humans

Shigemura, N., Shirosaki, S., Ohkuri, T., Sanematsu, K., Islam, A. A. S., Ogiwara, Y., Kawai, M., Yoshida, R. & Ninomiya, Y., Sep 1 2009, In : American Journal of Clinical Nutrition. 90, 3, p. 764S-769S

Research output: Contribution to journalArticle

Genes
Rodentia
Taste Perception
Guanosine Monophosphate
Purine Nucleotides
2008
86 Citations (Scopus)

Diurnal variation of human sweet taste recognition thresholds is correlated with plasma leptin levels

Nakamura, Y., Sanematsu, K., Ohta, R., Shirosaki, S., Koyano, K., Nonaka, K., Shigemura, N. & Ninomiya, Y., Oct 1 2008, In : Diabetes. 57, 10, p. 2661-2665 5 p.

Research output: Contribution to journalArticle

Taste Threshold
Leptin
Meals
Leptin Receptors
Sodium Glutamate
2006
61 Citations (Scopus)

Taste responsiveness of fungiform taste cells with action potentials

Yoshida, R., Shigemura, N., Sanematsu, K., Yasumatsu, K., Ishizuka, S. & Ninomiya, Y., Dec 1 2006, In : Journal of Neurophysiology. 96, 6, p. 3088-3095 8 p.

Research output: Contribution to journalArticle

Action Potentials
Nerve Fibers
Taste Buds
Saccharin
Quinine
2005
7 Citations (Scopus)

Mouse strain differences in Gurmarin-sensitivity of sweet taste responses are not associated with polymorphisms of the sweet receptor gene, Tas1r3

Sanematsu, K., Yasumatsu, K., Yoshida, R., Shigemura, N. & Ninomiya, Y., Jul 1 2005, In : Chemical Senses. 30, 6, p. 491-496 6 p.

Research output: Contribution to journalArticle

strain differences
genetic polymorphism
receptors
mice
Genes
14 Citations (Scopus)

Taste receptor cells responding with action potentials to taste stimuli and their molecular expression of taste related genes

Yoshida, R., Sanematsu, K., Shigemura, N., Yasumatsu, K. & Ninomiya, Y., Jan 1 2005, In : Chemical Senses. 30 SUPPL. 1, p. i19-i20

Research output: Contribution to journalArticle

taste sensitivity
patch-clamp technique
sweeteners
gene expression regulation
palps