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Research Output 2012 2019

  • 96 Citations
  • 5 h-Index
  • 10 Article
2019

DMSO-Perturbing Assay for Identifying Promiscuous Enzyme Inhibitors

Tomohara, K., Adachi, I., Horino, Y., Kesamaru, H., Abe, H., Suyama, K. & Nose, T., Jan 1 2019, In : ACS Medicinal Chemistry Letters. 10, 6, p. 923-928 6 p.

Research output: Contribution to journalArticle

Enzyme Inhibitors
Dimethyl Sulfoxide
Assays
Enzymes
Conformations
2017
3 Citations (Scopus)

Controllable Stereoselective Synthesis of (Z)- and (E)-Homoallylic Alcohols Using a Palladium-Catalyzed Three-Component Reaction

Horino, Y., Sugata, M., Mutsuura, I., Tomohara, K. & Abe, H., Nov 3 2017, In : Organic Letters. 19, 21, p. 5968-5971 4 p.

Research output: Contribution to journalArticle

Palladium
palladium
alcohols
Alcohols
aldehydes
3 Citations (Scopus)

Discovery of hyaluronidase inhibitors from natural products and their mechanistic characterization under DMSO-perturbed assay conditions

Tomohara, K., Ito, T., Onikata, S., Kato, A. & Adachi, I., Jan 1 2017, In : Bioorganic and Medicinal Chemistry Letters. 27, 7, p. 1620-1623 4 p.

Research output: Contribution to journalArticle

Hyaluronoglucosaminidase
Catechin
Dimethyl Sulfoxide
Biological Products
Assays
4 Citations (Scopus)

Multiple production of α,α-disubstituted amino acid derivatives through direct chemical derivatization of natural plant extracts: An apparently difficult but successful route

Tomohara, K., Ito, T., Furusawa, K., Hasegawa, N., Tsuge, K., Kato, A. & Adachi, I., Jan 1 2017, In : Tetrahedron Letters. 58, 32, p. 3143-3147 5 p.

Research output: Contribution to journalArticle

Paeonia
Hydantoins
Ginger
Carbamates
Plant Extracts
2016
5 Citations (Scopus)

Asymmetric synthesis of multisubstituted dihydrobenzofurans by intramolecular conjugate addition of short-lived C-O axially chiral enolates

Tomohara, K., Kasamatsu, K., Yoshimura, T., Furuta, T. & Kawabata, T., Jan 1 2016, In : Chemical and Pharmaceutical Bulletin. 64, 7, p. 899-906 8 p.

Research output: Contribution to journalArticle

Addition reactions
Carbon
9 Citations (Scopus)

Direct chemical derivatization of natural plant extract: Straightforward synthesis of natural plant-like hydantoin

Tomohara, K., Ito, T., Hasegawa, N., Kato, A. & Adachi, I., Feb 24 2016, In : Tetrahedron Letters. 57, 8, p. 924-927 4 p.

Research output: Contribution to journalArticle

Hydantoins
Curcuma
Plant Extracts
Chemical properties
Carbon
3 Citations (Scopus)

Interpreting the behavior of concentration-response curves of hyaluronidase inhibitors under DMSO-perturbed assay conditions

Tomohara, K., Ito, T., Onikata, S., Furusawa, K., Kato, A. & Adachi, I., Jul 1 2016, In : Bioorganic and Medicinal Chemistry Letters. 26, 13, p. 3153-3157 5 p.

Research output: Contribution to journalArticle

Hyaluronoglucosaminidase
Dimethyl Sulfoxide
Assays
Hyaluronic Acid
Enzymes
2013
16 Citations (Scopus)

Asymmetric induction via short-lived chiral enolates with a chiral C-O axis

Yoshimura, T., Tomohara, K. & Kawabata, T., May 15 2013, In : Journal of the American Chemical Society. 135, 19, p. 7102-7105 4 p.

Research output: Contribution to journalArticle

Cyclic Ethers
Ethers
Cyclization
Half-Life
Carbon
38 Citations (Scopus)

Asymmetric α-arylation of amino acid derivatives by clayden rearrangement of ester enolates via memory of chirality

Tomohara, K., Yoshimura, T., Hyakutake, R., Yang, P. & Kawabata, T., Sep 11 2013, In : Journal of the American Chemical Society. 135, 36, p. 13294-13297 4 p.

Research output: Contribution to journalArticle

Hydantoins
Chirality
Amino acids
Esters
Carbon
2012
15 Citations (Scopus)

Protonation-assisted conjugate addition of axially chiral enolates: Asymmetric synthesis of multisubstituted β-lactams from α-amino acids

Yoshimura, T., Takuwa, M., Tomohara, K., Uyama, M., Hayashi, K., Yang, P., Hyakutake, R., Sasamori, T., Tokitoh, N. & Kawabata, T., Nov 26 2012, In : Chemistry - A European Journal. 18, 48, p. 15330-15336 7 p.

Research output: Contribution to journalArticle

Lactams
Protonation
Amino acids
Amino Acids
Carbonates