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Research Output 1967 2019

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2019

Mouse polycomb group gene Cbx2 promotes osteoblastic but suppresses adipogenic differentiation in postnatal long bones

Katoh-Fukui, Y., Baba, T., Sato, T., Otake, H., Nagakui-Noguchi, Y., Shindo, M., Suyama, M., Ohkawa, Y., Tsumura, H., Morohashi, K. I. & Fukami, M., Mar 2019, In : Bone. 120, p. 219-231 13 p.

Research output: Contribution to journalArticle

Mesenchymal Stromal Cells
Bone and Bones
Cell Lineage
Genes
Polycomb-Group Proteins
1 Citation (Scopus)

Three populations of adult Leydig cells in mouse testes revealed by a novel mouse HSD3B1-specific rat monoclonal antibody

Yokoyama, C., Chigi, Y., Baba, T., Ohshitanai, A., Harada, Y., Takahashi, F. & Morohashi, K. I., Apr 16 2019, In : Biochemical and Biophysical Research Communications. 511, 4, p. 916-920 5 p.

Research output: Contribution to journalArticle

Leydig Cells
Testis
Rats
3-Hydroxysteroid Dehydrogenases
Steroids
2018
1 Citation (Scopus)

Ad4BP/SF-1 regulates cholesterol synthesis to boost the production of steroids

Baba, T., Otake, H., Inoue, M., Sato, T., Ishihara, Y., Moon, J. Y., Tsuchiya, M., Miyabayashi, K., Ogawa, H., Shima, Y., Wang, L., Sato, R., Yamazaki, T., Suyama, M., Nomura, M., Choi, M. H., Ohkawa, Y. & Morohashi, K. I., Dec 1 2018, In : Communications Biology. 1, 1, 18.

Research output: Contribution to journalArticle

Open Access
steroids
Steroids
Cholesterol
cholesterol
Metabolic Networks and Pathways
1 Citation (Scopus)

Le développement du cortex surrénalien: leçons des modèles animaux

Translated title of the contribution: Adrenocortical development: Lessons from mouse modelsDumontet, T., Sahut-Barnola, I., Septier, A., Montanier, N., Plotton, I., Roucher-Boulez, F., Ducros, V., Lefrançois-Martinez, A. M., Pointud, J. C., Zubair, M., Morohashi, K-I., Breault, D. T., Val, P. & Martinez, A., Jun 1 2018, In : Annales d'Endocrinologie. 79, 3, p. 95-97 3 p.

Research output: Contribution to journalArticle

Zona Reticularis
Cyclic AMP-Dependent Protein Kinases
Adrenarche
Zona Fasciculata
Cushing Syndrome
15 Citations (Scopus)

PKA signaling drives reticularis differentiation and sexually dimorphic adrenal cortex renewal

Dumontet, T., Sahut-Barnola, I., Septier, A., Montanier, N., Plotton, I., Roucher-Boulez, F., Ducros, V., Lefrançois-Martinez, A. M., Pointud, J. C., Zubair, M., Morohashi, K. I., Breault, D. T., Val, P. & Martinez, A., Jan 25 2018, In : JCI Insight. 3, 2

Research output: Contribution to journalArticle

Open Access
Adrenal Cortex
Androgens
Adrenarche
Zona Reticularis
Adrenocortical Hyperfunction
2017
11 Citations (Scopus)

Alterations in Fetal Leydig Cell Gene Expression during Fetal and Adult Development

Miyabayashi, K., Shima, Y., Inoue, M., Sato, T., Baba, T., Ohkawa, Y., Suyama, M. & Morohashi, K. I., May 1 2017, In : Sexual Development. 11, 2, p. 53-63 11 p.

Research output: Contribution to journalArticle

Leydig Cells
Fetal Development
Gene Expression
Testis
Mitochondrial Genes
1 Citation (Scopus)

Differential lactate and cholesterol synthetic activities in XY and XX Sertoli cells

Shishido, Y., Baba, T., Sato, T., Shima, Y., Miyabayashi, K., Inoue, M., Akiyama, H., Kimura, H., Kanai, Y., Ishihara, Y., Haraguchi, S., Miyazaki, A., Rozman, D., Yamazaki, T., Choi, M. H., Ohkawa, Y., Suyama, M. & Morohashi, K. I., Jan 1 2017, In : Scientific reports. 7, 41912.

Research output: Contribution to journalArticle

Sertoli Cells
Lactic Acid
Cholesterol
Germ Cells
Nursing
23 Citations (Scopus)

Identical NR5A1 Missense Mutations in Two Unrelated 46,XX Individuals with Testicular Tissues

Igarashi, M., Takasawa, K., Hakoda, A., Kanno, J., Takada, S., Miyado, M., Baba, T., Morohashi, K. I., Tajima, T., Hata, K., Nakabayashi, K., Matsubara, Y., Sekido, R., Ogata, T., Kashimada, K. & Fukami, M., Jan 1 2017, In : Human mutation. 38, 1, p. 39-42 4 p.

Research output: Contribution to journalArticle

Missense Mutation
Mutation
46, XX Testicular Disorders of Sex Development
46,XY Gonadal Dysgenesis
Ovotesticular Disorders of Sex Development
17 Citations (Scopus)

Leydig progenitor cells in fetal testis

Shima, Y. & Morohashi, K. I., Apr 15 2017, In : Molecular and Cellular Endocrinology. 445, p. 55-64 10 p.

Research output: Contribution to journalArticle

Leydig Cells
Androgens
Testis
Stem Cells
Cells
4 Citations (Scopus)

Lysosomal activity maintains glycolysis and cyclin E1 expression by mediating Ad4BP/SF-1 stability for proper steroidogenic cell growth

Syu, J. S., Baba, T., Huang, J. Y., Ogawa, H., Hsieh, C. H., Hu, J. X., Chen, T. Y., Lin, T. C., Tsuchiya, M., Morohashi, K. I., Huang, B. M., Lu, F. I. & Wang, C. Y., Jan 1 2017, In : Scientific reports. 7, 1, 240.

Research output: Contribution to journalArticle

Steroidogenic Factor 1
Cyclins
Glycolysis
Growth
Protein Stability

Mechanism for sex differentiation of the gonads

Morohashi, K. I., Jan 1 2017, In : Japanese Journal of Clinical Urology. 71, 10, p. 746-751 6 p.

Research output: Contribution to journalArticle

Sex Differentiation
Gonads
3 Citations (Scopus)

Role of Ad4-binding protein/steroidogenic factor 1 in regulating NADPH production in adrenocortical Y-1 cells

Li, B., Baba, T., Miyabayashi, K., Sato, T., Shima, Y., Ichinose, T., Miura, D., Ohkawa, Y., Suyama, M. & Morohashi, K. I., Jan 1 2017, In : Endocrine Journal. 64, 3, p. 315-324 10 p.

Research output: Contribution to journalArticle

Steroidogenic Factor 1
NADP
Genes
Pentose Phosphate Pathway
Chromatin Immunoprecipitation
3 Citations (Scopus)

Timing of adrenal regression controlled by synergistic interaction between Sf1 SUMOylation and Dax1

Xing, Y., Morohashi, K. I., Ingraham, H. A. & Hammer, G. D., Oct 15 2017, In : Development (Cambridge). 144, 20, p. 3798-3807 10 p.

Research output: Contribution to journalArticle

Sumoylation
Steroidogenic Factor 1
Adrenal Cortex
Cytoplasmic and Nuclear Receptors
Knockout Mice
2016
22 Citations (Scopus)

Isolation and characterization of Fetal Leydig progenitor cells of male mice

Inoue, M., Shima, Y., Miyabayashi, K., Tokunaga, K., Sato, T., Baba, T., Ohkawa, Y., Akiyama, H., Suyama, M. & Morohashi, K. I., Mar 2016, In : Endocrinology. 157, 3, p. 1222-1233 12 p.

Research output: Contribution to journalArticle

Leydig Cells
Stem Cells
Testis
Growth Factor Receptors
Transcriptome
6 Citations (Scopus)

Neuregulin 1 regulates proliferation of leydig cells to support spermatogenesis and sexual behavior in adult mice

Umehara, T., Kawashima, I., Kawai, T., Hoshino, Y., Morohashi, K. I., Shima, Y., Zeng, W., Richards, J. S. & Shimada, M., Dec 2016, In : Endocrinology. 157, 12, p. 4899-4913 15 p.

Research output: Contribution to journalArticle

Neuregulin-1
Leydig Cells
Spermatogenesis
Sexual Behavior
Testis
11 Citations (Scopus)

SF-1 deficiency causes lipid accumulation in Leydig cells via suppression of STAR and CYP11A1

Hatano, M., Migita, T., Ohishi, T., Shima, Y., Ogawa, Y., Morohashi, K. I., Hasegawa, Y. & Shibasaki, F., Nov 1 2016, In : Endocrine. 54, 2, p. 484-496 13 p.

Research output: Contribution to journalArticle

Steroidogenic Factor 1
Cholesterol Side-Chain Cleavage Enzyme
Leydig Cells
XY Disorders of Sex Development 46
Lipids
2015
28 Citations (Scopus)

Fetal leydig cells persist as an androgen-independent subpopulation in the postnatal testis

Shima, Y., Matsuzaki, S., Miyabayashi, K., Otake, H., Baba, T., Kato, S., Huhtaniemi, I. & Morohashi, K. I., Nov 2015, In : Molecular Endocrinology. 29, 11, p. 1581-1593 13 p.

Research output: Contribution to journalArticle

Leydig Cells
Androgens
Testis
Androgen Receptors
Knockout Mice
5 Citations (Scopus)

Heterogeneity of ovarian theca and interstitial gland cells in Mice

Miyabayashi, K., Tokunaga, K., Otake, H., Baba, T., Shima, Y. & Morohashi, K., Jun 3 2015, In : PloS one. 10, 6, e0128352.

Research output: Contribution to journalArticle

Genes
Gene expression
Reporter Genes
reporter genes
mice
4 Citations (Scopus)

Selective autophagic receptor p62 regulates the abundance of transcriptional coregulator ARIP4 during nutrient starvation

Tsuchiya, M., Isogai, S., Taniguchi, H., Tochio, H., Shirakawa, M., Morohashi, K. I., Hiraoka, Y., Haraguchi, T. & Ogawa, H., Sep 28 2015, In : Scientific reports. 5, 14498.

Research output: Contribution to journalArticle

Receptor-Interacting Protein Serine-Threonine Kinases
Androgen Receptors
Starvation
Food
Ubiquitin
9 Citations (Scopus)

Testicular dysgenesis/regression without campomelic dysplasia in patients carrying missense mutations and upstream deletion of sox9

Katoh-Fukui, Y., Igarashi, M., Nagasaki, K., Horikawa, R., Nagai, T., Tsuchiya, T., Suzuki, E., Miyado, M., Hata, K., Nakabayashi, K., Hayashi, K., Matsubara, Y., Baba, T., Morohashi, K. I., Igarashi, A., Ogata, T., Takada, S. & Fukami, M., Jan 1 2015, In : Molecular Genetics and Genomic Medicine. 3, 6, p. 550-557 8 p.

Research output: Contribution to journalArticle

Open Access
Campomelic Dysplasia
Missense Mutation
XY Disorders of Sex Development 46
Mutation
Exome
2014
35 Citations (Scopus)

Glycolytic genes are targets of the nuclear receptor Ad4BP/SF-1

Baba, T., Otake, H., Sato, T., Miyabayashi, K., Shishido, Y., Wang, C. Y., Shima, Y., Kimura, H., Yagi, M., Ishihara, Y., Hino, S., Ogawa, H., Nakao, M., Yamazaki, T., Kang, D., Ohkawa, Y., Suyama, M., Chung, B. C. & Morohashi, K. I., Apr 14 2014, In : Nature communications. 5, 3634.

Research output: Contribution to journalArticle

Cytoplasmic and Nuclear Receptors
genes
Genes
Tissue
adrenal gland
18 Citations (Scopus)

Identification of myelin transcription factor 1 (MyT1) as a subunit of the neural cell type-specific lysine-specific demethylase 1 (LSD1) complex

Yokoyama, A., Igarashi, K., Sato, T., Takagi, K., Otsuka, M. I., Shishido, Y., Baba, T., Ito, R., Kanno, J., Ohkawa, Y., Morohashi, K. I. & Sugawara, A., Jun 27 2014, In : Journal of Biological Chemistry. 289, 26, p. 18152-18162 11 p.

Research output: Contribution to journalArticle

Myelin Sheath
Lysine
Transcription Factors
Genes
Histone Demethylases
2013
35 Citations (Scopus)

Aristaless Related Homeobox Gene, Arx, Is Implicated in Mouse Fetal Leydig Cell Differentiation Possibly through Expressing in the Progenitor Cells

Miyabayashi, K., Katoh-Fukui, Y., Ogawa, H., Baba, T., Shima, Y., Sugiyama, N., Kitamura, K. & Morohashi, K. I., Jun 28 2013, In : PloS one. 8, 6, e68050.

Research output: Contribution to journalArticle

homeotic genes
Leydig cells
Leydig Cells
Homeobox Genes
cell differentiation
90 Citations (Scopus)

Contribution of Leydig and Sertoli cells to testosterone production in mouse fetal testes

Shima, Y., Miyabayashi, K., Haraguchi, S., Arakawa, T., Otake, H., Baba, T., Matsuzaki, S., Shishido, Y., Akiyama, H., Tachibana, T., Tsutsui, K. & Morohashi, K. I., Jan 7 2013, In : Molecular Endocrinology. 27, 1, p. 63-73 11 p.

Research output: Contribution to journalArticle

Leydig Cells
Sertoli Cells
Testosterone
Testis
Androstenedione
19 Citations (Scopus)

Heterogeneity in sexual bipotentiality and plasticity of granulosa cells in developing mouse ovaries

Harikae, K., Miura, K., Shinomura, M., Matoba, S., Hiramatsu, R., Tsunekawa, N., Kanai-Azuma, M., Kurohmaru, M., Morohashi, K-I. & Kanai, Y., Jul 1 2013, In : Journal of Cell Science. 126, 13, p. 2834-2844 11 p.

Research output: Contribution to journalArticle

Granulosa Cells
Ovary
Disorders of Sex Development
Ovarian Follicle
Sertoli Cells
36 Citations (Scopus)

Homeoproteins Six1 and Six4 regulate male sex determination and mouse gonadal development

Fujimoto, Y., Tanaka, S. S., Yamaguchi, Y. L., Kobayashi, H., Kuroki, S., Tachibana, M., Shinomura, M., Kanai, Y., Morohashi, K. I., Kawakami, K. & Nishinakamura, R., Aug 26 2013, In : Developmental Cell. 26, 4, p. 416-430 15 p.

Research output: Contribution to journalArticle

Homeodomain Proteins
Gonads
Transcription Factors
Genes
Chemical activation
2012
82 Citations (Scopus)

Cbx2, a polycomb group gene, is required for Sry gene expression in mice

Katoh-Fukui, Y., Miyabayashi, K., Komatsu, T., Owaki, A., Baba, T., Shima, Y., Kidokoro, T., Kanai, Y., Schedl, A., Wilhelm, D., Koopman, P., Okuno, Y. & Morohashi, K. I., Feb 1 2012, In : Endocrinology. 153, 2, p. 913-924 12 p.

Research output: Contribution to journalArticle

sry Genes
Gonads
Testis
Gene Expression
Knockout Mice
33 Citations (Scopus)

Identification of an enhancer in the Ad4BP/SF-1 gene specific for fetal leydig cells

Shima, Y., Miyabayashi, K., Baba, T., Otake, H., Oka, S., Zubair, M. & Morohashi, K. I., Jan 2012, In : Endocrinology. 153, 1, p. 417-425 9 p.

Research output: Contribution to journalArticle

Steroidogenic Factor 1
Leydig Cells
Genes
Gonads
Adrenal Glands
15 Citations (Scopus)

Mamld1 deficiency significantly reduces mRNA expression levels of multiple genes expressed in mouse fetal leydig cells but permits normal genital and reproductive development

Miyado, M., Nakamura, M., Miyado, K., Morohashi, K. I., Sano, S., Nagata, E., Fukami, M. & Ogata, T., Dec 1 2012, In : Endocrinology. 153, 12, p. 6033-6040 8 p.

Research output: Contribution to journalArticle

Leydig Cells
Messenger RNA
Knockout Mice
Genes
3-Hydroxysteroid Dehydrogenases
10 Citations (Scopus)

Wnt family genes and their modulation in the ovary-independent and persistent vaginal epithelial cell proliferation and keratinization induced by neonatal diethylstilbestrol exposure in mice

Nakamura, T., Miyagawa, S., Katsu, Y., Watanabe, H., Mizutani, T., Sato, T., Morohashi, K. I., Takeuchi, T., Iguchi, T. & Ohta, Y., Jun 14 2012, In : Toxicology. 296, 1-3, p. 13-19 7 p.

Research output: Contribution to journalArticle

Diethylstilbestrol
Cell proliferation
Vagina
Ovary
Genes
2011
43 Citations (Scopus)

DNA methylation of intronic enhancers directs tissue-specific expression of steroidogenic factor 1/adrenal 4 binding protein (SF-1/Ad4BP)

Hoivik, E. A., Bjanesoy, T. E., Mai, O., Okamoto, S., Minokoshi, Y., Shima, Y., Morohashi, K. I., Boehm, U. & Bakke, M., May 1 2011, In : Endocrinology. 152, 5, p. 2100-2112 13 p.

Research output: Contribution to journalArticle

Steroidogenic Factor 1
DNA Methylation
Ventromedial Hypothalamic Nucleus
Methylation
Cytoplasmic and Nuclear Receptors
2010
38 Citations (Scopus)

Abnormal epithelial cell polarity and ectopic Epidermal Growth Factor Receptor (EGFR) expression induced in Emx2 KO Embryonic Gonads

Kusaka, M., Katoh-Fukui, Y., Ogawa, H., Miyabayashi, K., Baba, T., Shima, Y., Sugiyama, N., Sugimoto, Y., Okuno, Y., Kodama, R., Iizuka-Kogo, A., Senda, T., Sasaoka, T., Kitamura, K., Aizawa, S. & Morohashi, K. I., Dec 1 2010, In : Endocrinology. 151, 12, p. 5893-5904 12 p.

Research output: Contribution to journalArticle

Cell Polarity
Tight Junctions
Gonads
Epidermal Growth Factor Receptor
Tyrosine
5 Citations (Scopus)

Production and characterization of monoclonal antibodies to mouse germ cells

Yokoyama, C., Katoh-Fukui, Y., Morohashi, K. I., Konno, D., Azuma, M. & Tachibana, T., Feb 1 2010, In : Hybridoma. 29, 1, p. 53-57 5 p.

Research output: Contribution to journalArticle

Germ Cells
Gonads
Monoclonal Antibodies
Hybridomas
Antigens
2009
124 Citations (Scopus)

A critical time window of Sry action in gonadal sex determination in mice

Hiramatsu, R., Matoba, S., Kanai-Azuma, M., Tsunekawa, N., Katoh-Fukui, Y., Kurohmaru, M., Morohashi, K. I., Wilhelm, D., Koopman, P. & Kanai, Y., Apr 14 2009, In : Development. 136, 1, p. 129-138 10 p.

Research output: Contribution to journalArticle

Sertoli Cells
Testis
sry Genes
Granulosa Cells
Gonads
9 Citations (Scopus)

Generation of rat monoclonal antibodies specific for Ad4BPSF-1

Yokoyama, C., Komatsu, T., Ogawa, H., Morohashi, K. I., Azuma, M. & Tachibana, T., Apr 1 2009, In : Hybridoma. 28, 2, p. 113-119 7 p.

Research output: Contribution to journalArticle

Steroidogenic Factor 1
Carrier Proteins
Monoclonal Antibodies
Cytoplasmic and Nuclear Receptors
Immunoblotting
15 Citations (Scopus)

Transcriptional suppression by transient recruitment of ARIP4 to sumoylated nuclear receptor Ad4BP/SF-1

Ogawa, H., Komatsu, T., Hiraoka, Y. & Morohashi, K. I., Oct 1 2009, In : Molecular biology of the cell. 20, 19, p. 4235-4245 11 p.

Research output: Contribution to journalArticle

Cytoplasmic and Nuclear Receptors
Transcription Factors
Chromatin Assembly and Disassembly
Ubiquitin
Small Interfering RNA
35 Citations (Scopus)

Transgenic expression of Ad4BP/SF-1 in fetal adrenal progenitor cells leads to ectopic adrenal formation

Zubair, M., Oka, S., Parker, K. L. & Morohashi, K. I., Oct 14 2009, In : Molecular Endocrinology. 23, 10, p. 1657-1667 11 p.

Research output: Contribution to journalArticle

Steroidogenic Factor 1
Adrenal Glands
Stem Cells
Homeodomain Proteins
Choristoma
2008
61 Citations (Scopus)

Developmental links between the fetal and adult zones of the adrenal cortex revealed by lineage tracing

Zubair, M., Parker, K. L. & Morohashi, K. I., Dec 1 2008, In : Molecular and cellular biology. 28, 23, p. 7030-7040 11 p.

Research output: Contribution to journalArticle

Adrenal Cortex
Gonads
Cell Lineage
Cytoplasmic and Nuclear Receptors
Transgenes
32 Citations (Scopus)

Disruption of aryl hydrocarbon receptor (AhR) induces regression of the seminal vesicle in aged male mice

Baba, T., Shima, Y., Owaki, A., Mimura, J., Oshima, M., Fujii-Kuriyama, Y. & Morohashi, K. I., Apr 1 2008, In : Sexual Development. 2, 1, p. 1-11 11 p.

Research output: Contribution to journalArticle

Aryl Hydrocarbon Receptors
Seminal Vesicles
Reproduction
Fertility
Testosterone
6 Citations (Scopus)

Identification of NR5A1 (SF-1/AD4BP) gene expression modulators by large-scale gain and loss of function studies

Sakai, N., Terami, H., Suzuki, S., Haga, M., Nomoto, K., Tsuchida, N., Morohashi, K. I., Saito, N., Asada, M., Hashimoto, M., Harada, D., Asahara, H., Ishikawa, T., Shimada, F. & Sakurada, K., Sep 1 2008, In : Journal of Endocrinology. 198, 3, p. 489-497 9 p.

Research output: Contribution to journalArticle

Gene Expression
Protein Kinase C
Small Interfering RNA
Inducible T-Cell Co-Stimulator Protein
TATA-Binding Protein Associated Factors
12 Citations (Scopus)

Importance of forkhead transcription factor Fkhl18 for development of testicular vasculature

Sato, Y., Baba, T., Zubair, M., Miyabayashi, K., Toyama, Y., Maekawa, M., Owaki, A., Mizusaki, H., Sawamura, T., Toshimori, K., Morohashi, K. I. & Katoh-Fukui, Y., Sep 1 2008, In : Molecular Reproduction and Development. 75, 9, p. 1361-1371 11 p.

Research output: Contribution to journalArticle

Forkhead Transcription Factors
Apoptosis
Testis
Endothelial Cells
Fas Ligand Protein
49 Citations (Scopus)

Mastermind-like domain-containing 1 (MAMLD1 or CXorf6) transactivates the Hes3 promoter, augments testosterone production, and contains the SF1 target sequence

Fukami, M., Wada, Y., Okada, M., Kato, F., Katsumata, N., Baba, T., Morohashi, K. I., Laporte, J., Kitagawa, M. & Ogata, T., Feb 29 2008, In : Journal of Biological Chemistry. 283, 9, p. 5525-5532 8 p.

Research output: Contribution to journalArticle

Steroidogenic Factor 1
Chromosomes, Human, Pair 1
X Chromosome
Chromosomes
Open Reading Frames
59 Citations (Scopus)

Mechanism of asymmetric ovarian development in chick embryos

Ishimaru, Y., Komatsu, T., Kasahara, M., Katoh-Fukui, Y., Ogawa, H., Toyama, Y., Maekawa, M., Toshimori, K., Chandraratna, R. A. S., Morohashi, K. I. & Yoshioka, H., Feb 1 2008, In : Development. 135, 4, p. 677-685 9 p.

Research output: Contribution to journalArticle

Gonads
Chick Embryo
Cyclin D1
Tretinoin
Estrogen Receptors
27 Citations (Scopus)

Pituitary homeobox 2 regulates adrenal4 binding protein/steroidogenic factor-1 gene transcription in the pituitary gonadotrope through interaction with the intronic enhancer

Shima, Y., Zubair, M., Komatsu, T., Oka, S., Yokoyama, C., Tachibana, T., Hjalt, T. A., Drouin, J. & Morohashi, K. I., Jul 1 2008, In : Molecular Endocrinology. 22, 7, p. 1633-1646 14 p.

Research output: Contribution to journalArticle

Steroidogenic Factor 1
Homeobox Genes
Carrier Proteins
Ventromedial Hypothalamic Nucleus
Genes
39 Citations (Scopus)

Up-regulation of SOX9 in human sex-determining region on the Y chromosome (SRY)-negative XX males

Kojima, Y., Hayashi, Y., Mizuno, K., Sasaki, S., Fukui, Y., Koopman, P., Morohashi, K-I. & Kohri, K., May 1 2008, In : Clinical Endocrinology. 68, 5, p. 791-799 9 p.

Research output: Contribution to journalArticle

Y Chromosome
Up-Regulation
Testis
Genes
Gonads
2007
153 Citations (Scopus)

Atrazine-induced aromatase expression is SF-1 dependent: Implications for endocrine disruption in wildlife and reproductive cancers in humans

Fan, W. Q., Yanase, T., Morinaga, H., Gondo, S., Okabe, T., Nomura, M., Komatsu, T., Morohashi, K. I., Hayes, T. B., Takayanagi, R. & Nawata, H., May 1 2007, In : Environmental Health Perspectives. 115, 5, p. 720-727 8 p.

Research output: Contribution to journalArticle

Steroidogenic Factor 1
Atrazine
Aromatase
Neoplasms
Simazine
288 Citations (Scopus)

Foxl2 up-regulates aromatase gene transcription in a female-specific manner by binding to the promoter as well as interacting with Ad4 binding protein/steroidogenic factor

Wang, D. S., Kobayashi, T., Zhou, L. Y., Paul-Prasanth, B., Ijiri, S., Sakai, F., Okubo, K., Morohashi, K. I. & Nagahama, Y., Mar 1 2007, In : Molecular Endocrinology. 21, 3, p. 712-725 14 p.

Research output: Contribution to journalArticle

Steroidogenic Factor 1
Aromatase
Tilapia
Fishes
Up-Regulation
148 Citations (Scopus)

Germ cells are essential for sexual dimorphism in the medaka gonad

Kurokawa, H., Saito, D., Nakamura, S., Katoh-Fukui, Y., Ohta, K., Baba, T., Morohashi, K. I. & Tanaka, M., Oct 23 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 43, p. 16958-16963 6 p.

Research output: Contribution to journalArticle

Oryzias
Gonads
Germ Cells
Sex Characteristics
Sex Differentiation
32 Citations (Scopus)

Hypogonadotropic hypogonadism in an adult female with a heterozygous hypomorphic mutation of SOX2

Sato, N., Kamachi, Y., Kondoh, H., Shima, Y., Morohashi, K. I., Horikawa, R. & Ogata, T., Feb 1 2007, In : European Journal of Endocrinology. 156, 2, p. 167-171 5 p.

Research output: Contribution to journalArticle

Hypogonadism
Mutant Proteins
Mutation
Anophthalmos
Eye Abnormalities
11 Citations (Scopus)

Liver receptor homologue-1 (LRH-1) activates the promoter of brain aromatase (cyp19a2) in a teleost fish, the medaka, Oryzias latipes

Ohmuro-Matsuyama, Y., Okubo, K., Matsuda, M., Ijiri, S., Wang, D., Guan, G., Suzuki, T., Matsuyama, M., Morohashi, K. I. & Nagahama, Y., Sep 1 2007, In : Molecular Reproduction and Development. 74, 9, p. 1065-1071 7 p.

Research output: Contribution to journalArticle

Oryzias
Aromatase
Fishes
Liver
Brain