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Research Output

2020
Open Access
2019

A deletion in the Ctns gene causes renal tubular dysfunction and cystine accumulation in LEA/Tohm rats

Shimizu, Y., Yanobu-Takanashi, R., Nakano, K., Hamase, K., Shimizu, T. & Okamura, T., Feb 13 2019, In : Mammalian Genome. 30, 1-2, p. 23-33 11 p.

Research output: Contribution to journalArticle

D -Serine reflects kidney function and diseases

Hesaka, A., Sakai, S., Hamase, K., Ikeda, T., Matsui, R., Mita, M., Horio, M., Isaka, Y. & Kimura, T., Dec 1 2019, In : Scientific reports. 9, 1, 5104.

Research output: Contribution to journalArticle

Open Access
5 Citations (Scopus)

New applications of high-resolution analytical methods to study trace organic compounds in extraterrestrial materials

Naraoka, H., Hashiguchi, M., Sato, Y. & Hamase, K., Sep 2019, In : Life. 9, 3, 62.

Research output: Contribution to journalReview article

Open Access

Serum d-serine accumulation after proximal renal tubular damage involves neutral amino acid transporter Asc-1

Suzuki, M., Gonda, Y., Yamada, M., Vandebroek, A. A., Mita, M., Hamase, K., Yasui, M. & Sasabe, J., Dec 1 2019, In : Scientific reports. 9, 1, 16705.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Three-Dimensional High-Performance Liquid Chromatographic Determination of Asn, Ser, Ala, and Pro Enantiomers in the Plasma of Patients with Chronic Kidney Disease

Furusho, A., Koga, R., Akita, T., Mita, M., Kimura, T. & Hamase, K., Sep 17 2019, In : Analytical chemistry. 91, 18, p. 11569-11575 7 p.

Research output: Contribution to journalArticle

2018

D-Amino acids in molecular evolution in space – Absolute asymmetric photolysis and synthesis of amino acids by circularly polarized light

Sugahara, H., Meinert, C., Nahon, L., Jones, N. C., Hoffmann, S. V., Hamase, K., Takano, Y. & Meierhenrich, U. J., Jul 2018, In : Biochimica et Biophysica Acta - Proteins and Proteomics. 1866, 7, p. 743-758 16 p.

Research output: Contribution to journalReview article

7 Citations (Scopus)
13 Citations (Scopus)
4 Citations (Scopus)

Gut microbiota-derived D-serine protects against acute kidney injury

Nakade, Y., Iwata, Y., Furuichi, K., Mita, M., Hamase, K., Konno, R., Miyake, T., Sakai, N., Kitajima, S., Toyama, T., Shinozaki, Y., Sagara, A., Miyagawa, T., Hara, A., Shimizu, M., Kamikawa, Y., Sato, K., Oshima, M., Yoneda-Nakagawa, S., Yamamura, Y. & 8 others, Kaneko, S., Miyamoto, T., Katane, M., Homma, H., Morita, H., Suda, W., Hattori, M. & Wada, T., Oct 18 2018, In : JCI Insight. 3, 20

Research output: Contribution to journalArticle

Open Access
4 Citations (Scopus)

Structural and enzymatic properties of mammalian D-glutamate cyclase

Katane, M., Ariyoshi, M., Tateishi, S., Koiwai, S., Takaku, K., Nagai, K., Nakayama, K., Saitoh, Y., Miyamoto, T., Sekine, M., Mita, M., Hamase, K., Matoba, S. & Homma, H., Sep 15 2018, In : Archives of Biochemistry and Biophysics. 654, p. 10-18 9 p.

Research output: Contribution to journalArticle

2017

Amino acid and bioamine separations

Koga, R., Miyoshi, Y., Todoroki, K. & Hamase, K., Jan 1 2017, Liquid Chromatography: Applications: Second Edition. Elsevier Inc., Vol. 2. p. 87-106 20 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

D-Glutamate is metabolized in the heart mitochondria

Ariyoshi, M., Katane, M., Hamase, K., Miyoshi, Y., Nakane, M., Hoshino, A., Okawa, Y., Mita, Y., Kaimoto, S., Uchihashi, M., Fukai, K., Ono, K., Tateishi, S., Hato, D., Yamanaka, R., Honda, S., Fushimura, Y., Iwai-Kanai, E., Ishihara, N., Mita, M. & 2 others, Homma, H. & Matoba, S., Mar 7 2017, In : Scientific reports. 7, 43911.

Research output: Contribution to journalArticle

22 Citations (Scopus)

Heterogeneity of D-serine distribution in the human central nervous system

Suzuki, M., Imanishi, N., Mita, M., Hamase, K., Aiso, S. & Sasabe, J., May 1 2017, In : ASN Neuro. 9, 3

Research output: Contribution to journalArticle

13 Citations (Scopus)

Mouse D-amino-acid oxidase: Distribution and physiological substrates

Koga, R., Miyoshi, Y., Sakaue, H., Hamase, K. & Konno, R., Dec 4 2017, In : Frontiers in Molecular Biosciences. 4, DEC, 82.

Research output: Contribution to journalReview article

11 Citations (Scopus)
2016

Chiral amino acid metabolomics for novel biomarker screening in the prognosis of chronic kidney disease

Kimura, T., Hamase, K., Miyoshi, Y., Yamamoto, R., Yasuda, K., Mita, M., Rakugi, H., Hayashi, T. & Isaka, Y., May 18 2016, In : Scientific reports. 6, 26137.

Research output: Contribution to journalArticle

53 Citations (Scopus)

Determination of D-amino acids and their distribution in mammals

Miyoshi, Y., Koga, R. & Hamase, K., Jan 1 2016, D-Amino Acids: Physiology, Metabolism, and Application. Springer Japan, p. 3-17 15 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Enantioselective determination of citrulline and ornithine in the urine of D-amino acid oxidase deficient mice using a two-dimensional high-performance liquid chromatographic system

Koga, R., Miyoshi, Y., Sato, Y., Mita, M., Konno, R., Lindner, W. & Hamase, K., Oct 7 2016, In : Journal of Chromatography A. 1467, p. 312-317 6 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Interplay between microbial d-amino acids and host d-amino acid oxidase modifies murine mucosal defence and gut microbiota

Sasabe, J., Miyoshi, Y., Rakoff-Nahoum, S., Zhang, T., Mita, M., Davis, B. M., Hamase, K. & Waldor, M. K., Jul 25 2016, In : Nature Microbiology. 1, 16125.

Research output: Contribution to journalArticle

34 Citations (Scopus)

Participation of D-serine in the development and reproduction of the silkworm Bombyx mori

Tanigawa, M., Suzuki, C., Niwano, K., Kanekatsu, R., Tanaka, H., Horiike, K., Hamase, K. & Nagata, Y., Apr 1 2016, In : Journal of insect physiology. 87, p. 20-29 10 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)
2015

Boronophenylalanine, a boron delivery agent for boron neutron capture therapy, is transported by ATB0,+, LAT1 and LAT2

Wongthai, P., Hagiwara, K., Miyoshi, Y., Wiriyasermkul, P., Wei, L., Ohgaki, R., Kato, I., Hamase, K., Nagamori, S. & Kanai, Y., Mar 1 2015, In : Cancer Science. 106, 3, p. 279-286 8 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)

Changes in d-aspartic acid and d-glutamic acid levels in the tissues and physiological fluids of mice with various d-aspartate oxidase activities

Han, H., Miyoshi, Y., Koga, R., Mita, M., Konno, R. & Hamase, K., Dec 10 2015, In : Journal of Pharmaceutical and Biomedical Analysis. 116, p. 47-52 6 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Design and synthesis of a novel pre-column derivatization reagent with a 6-methoxy-4-quinolone moiety for fluorescence and tandem mass spectrometric detection and its application to chiral amino acid analysis

Oyama, T., Negishi, E., Onigahara, H., Kusano, N., Miyoshi, Y., Mita, M., Nakazono, M., Ohtsuki, S., Ojida, A., Lindner, W. & Hamase, K., Dec 10 2015, In : Journal of Pharmaceutical and Biomedical Analysis. 116, p. 71-79 9 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Development of a fully-automated on-line oxidation column-switching HPLC system for the determination of endogenous melatonin in human clinical samples

Oyama, T., Nagai, R., Fujimoto, M., Konishi, R., Mita, M., Uezono, K., Zaitsu, K. & Hamase, K., Jan 1 2015, In : analytical sciences. 31, 11, p. 1129-1135 7 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Establishment of a two-dimensional chiral HPLC system for the simultaneous detection of lactate and 3-hydroxybutyrate enantiomers in human clinical samples

Liu, S. L., Oyama, T., Miyoshi, Y., Sheu, S. Y., Mita, M., Ide, T., Lindner, W., Hamase, K. & Lee, J. A., Dec 10 2015, In : Journal of Pharmaceutical and Biomedical Analysis. 116, p. 80-85 6 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Glycolytic flux controls D-serine synthesis through glyceraldehyde-3-phosphate dehydrogenase in astrocytes

Suzuki, M., Sasabe, J., Miyoshi, Y., Kuwasako, K., Muto, Y., Hamase, K., Matsuoka, M., Imanishi, N. & Aiso, S., Apr 28 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 17, p. E2217-E2224

Research output: Contribution to journalArticle

23 Citations (Scopus)

Lysocin e is a new antibiotic that targets menaquinone in the bacterial membrane

Hamamoto, H., Urai, M., Ishii, K., Yasukawa, J., Paudel, A., Murai, M., Kaji, T., Kuranaga, T., Hamase, K., Katsu, T., Su, J., Adachi, T., Uchida, R., Tomoda, H., Yamada, M., Souma, M., Kurihara, H., Inoue, M. & Sekimizu, K., Feb 1 2015, In : Nature Chemical Biology. 11, 2, p. 127-133 7 p.

Research output: Contribution to journalArticle

80 Citations (Scopus)

Recent advances on d-amino acid research

Hamase, K., Dec 10 2015, In : Journal of Pharmaceutical and Biomedical Analysis. 116, 1 p.

Research output: Contribution to journalEditorial

2 Citations (Scopus)

Simultaneous analysis of D-alanine, D-aspartic acid, and D-serine using chiral high-performance liquid chromatography-tandem mass spectrometry and its application to the rat plasma and tissues

Karakawa, S., Shimbo, K., Yamada, N., Mizukoshi, T., Miyano, H., Mita, M., Lindner, W. & Hamase, K., Nov 1 2015, In : Journal of Pharmaceutical and Biomedical Analysis. 115, p. 123-129 7 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)
2014

Cellular origin and regulation of D- and L-serine in in vitro and in vivo models of cerebral ischemia

Abe, T., Suzuki, M., Sasabe, J., Takahashi, S., Unekawa, M., Mashima, K., Iizumi, T., Hamase, K., Konno, R., Aiso, S. & Suzuki, N., Dec 1 2014, In : Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 34, 12, p. 1928-1935 8 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Chiral amino acid analysis of Japanese traditional Kurozu and the developmental changes during earthenware jar fermentation processes

Miyoshi, Y., Nagano, M., Ishigo, S., Ito, Y., Hashiguchi, K., Hishida, N., Mita, M., Lindner, W. & Hamase, K., Sep 1 2014, In : Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences. 966, p. 187-192 6 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

Ischemic acute kidney injury perturbs homeostasis of serine enantiomers in the body fluid in mice: Early detection of renal dysfunction using the ratio of serine enantiomers

Sasabe, J., Suzuki, M., Miyoshi, Y., Tojo, Y., Okamura, C., Ito, S., Konno, R., Mita, M., Hamase, K. & Aiso, S., Jan 29 2014, In : PloS one. 9, 1, e86504.

Research output: Contribution to journalArticle

26 Citations (Scopus)

Localization of Serine Racemase and Its Role in the Skin

Inoue, R., Yoshihisa, Y., Tojo, Y., Okamura, C., Yoshida, Y., Kishimoto, J., Luan, X., Watanabe, M., Mizuguchi, M., Nabeshima, Y., Hamase, K., Matsunaga, K., Shimizu, T. & Mori, H., Jan 1 2014, In : Journal of Investigative Dermatology. 134, 6, p. 1618-1626 9 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)
2013

Amino Acid and Bioamine Separations

Miyoshi, Y., Oyama, T., Koga, R. & Hamase, K., Jan 1 2013, Liquid Chromatography: Applications. Elsevier Inc., p. 131-147 17 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Citations (Scopus)
18 Citations (Scopus)
2012

Alteration of intrinsic amounts of D-serine in the mice lacking serine racemase and D-amino acid oxidase

Miyoshi, Y., Konno, R., Sasabe, J., Ueno, K., Tojo, Y., Mita, M., Aiso, S. & Hamase, K., Nov 1 2012, In : Amino Acids. 43, 5, p. 1919-1931 13 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

D-Amino acid oxidase controls motoneuron degeneration through D-serine

Sasabe, J., Miyoshi, Y., Suzuki, M., Mita, M., Konno, R., Matsuoka, M., Hamase, K. & Aiso, S., Jan 10 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 2, p. 627-632 6 p.

Research output: Contribution to journalArticle

115 Citations (Scopus)

D-Amino acids in the brain and mutant rodents lacking D-amino-acid oxidase activity

Yamanaka, M., Miyoshi, Y., Ohide, H., Hamase, K. & Konno, R., Nov 1 2012, In : Amino Acids. 43, 5, p. 1811-1821 11 p.

Research output: Contribution to journalReview article

28 Citations (Scopus)

Development of a simultaneous two-dimensional micro-HPLC analysis system for the chiral amino acid metabolomics study in mammals

Miyoshi, Y., Tojo, Y., Han, H., Mita, M. & Hamase, K., Jan 1 2012, In : bunseki kagaku. 61, 6, p. 489-499 11 p.

Research output: Contribution to journalArticle

Enantioselective two-dimensional high-performance liquid chromatographic determination of N-methyl-d-aspartic acid and its analogues in mammals and bivalves

Koga, R., Miyoshi, Y., Negishi, E., Kaneko, T., Mita, M., Lindner, W. & Hamase, K., Dec 21 2012, In : Journal of Chromatography A. 1269, p. 255-261 7 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

HPLC analysis of naturally occurring free d-amino acids in mammals

Miyoshi, Y., Koga, R., Oyama, T., Han, H., Ueno, K., Masuyama, K., Itoh, Y. & Hamase, K., Oct 1 2012, In : Journal of Pharmaceutical and Biomedical Analysis. 69, p. 42-49 8 p.

Research output: Contribution to journalReview article

62 Citations (Scopus)

Preliminary organic compound analysis of microparticles returned from Asteroid 25143 Itokawa by the Hayabusa mission

Naraoka, H., Mita, H., Hamase, K., Mita, M., Yabuta, H., Saito, K., Fukushima, K., Kitajima, F., Sandford, S. A., Nakamura, T., Noguchi, T., Okazaki, R., Nagao, K., Ebihara, M., Yurimoto, H., Tsuchiyama, A., Abe, M., Shirai, K., Ueno, M., Yada, T. & 6 others, Ishibashi, Y., Okada, T., Fujimura, A., Mukai, T., Yoshikawa, M. & Kawaguchi, J., Dec 1 2012, In : GEOCHEMICAL JOURNAL. 46, 1, p. 61-72 12 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)

Type 1 diabetes mellitus in mice increases hippocampal d-serine in the acute phase after streptozotocin injection

Suzuki, M., Sasabe, J., Furuya, S., Mita, M., Hamase, K. & Aiso, S., Jul 23 2012, In : Brain Research. 1466, p. 167-176 10 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)
2011
5 Citations (Scopus)

D-Amino acid metabolism in mammals: Biosynthesis, degradation and analytical aspects of the metabolic study

Ohide, H., Miyoshi, Y., Maruyama, R., Hamase, K. & Konno, R., Nov 1 2011, In : Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences. 879, 29, p. 3162-3168 7 p.

Research output: Contribution to journalReview article

60 Citations (Scopus)

D-Serine regulates cerebellar LTD and motor coordination through the δ glutamate receptor

Kakegawa, W., Miyoshi, Y., Hamase, K., Matsuda, S., Matsuda, K., Kohda, K., Emi, K., Motohashi, J., Konno, R., Zaitsu, K. & Yuzaki, M., May 1 2011, In : Nature Neuroscience. 14, 5, p. 603-613 11 p.

Research output: Contribution to journalArticle

93 Citations (Scopus)

Enantioselective micro-2D-HPLC determination of aspartic acid in the pineal glands of rodents with various melatonin contents

Han, H., Miyoshi, Y., Oyama, T., Konishi, R., Mita, M. & Hamase, K., Oct 1 2011, In : Journal of Separation Science. 34, 20, p. 2847-2853 7 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)
15 Citations (Scopus)

Simultaneous determination of d-aspartic acid and d-glutamic acid in rat tissues and physiological fluids using a multi-loop two-dimensional HPLC procedure

Han, H., Miyoshi, Y., Ueno, K., Okamura, C., Tojo, Y., Mita, M., Lindner, W., Zaitsu, K. & Hamase, K., Nov 1 2011, In : Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences. 879, 29, p. 3196-3202 7 p.

Research output: Contribution to journalArticle

39 Citations (Scopus)