If you made any changes in Pure these will be visible here soon.

Research Output 1991 2019

Filter
Article
2019

A deletion in the Ctns gene causes renal tubular dysfunction and cystine accumulation in LEA/Tohm rats

Shimizu, Y., Yanobu-Takanashi, R., Nakano, K., Hamase, K., Shimizu, T. & Okamura, T., Feb 13 2019, In : Mammalian Genome. 30, 1-2, p. 23-33 11 p.

Research output: Contribution to journalArticle

Cystine
Kidney
Glucose
Cystinosis
Genes
1 Citation (Scopus)

D -Serine reflects kidney function and diseases

Hesaka, A., Sakai, S., Hamase, K., Ikeda, T., Matsui, R., Mita, M., Horio, M., Isaka, Y. & Kimura, T., Dec 1 2019, In : Scientific reports. 9, 1, 5104.

Research output: Contribution to journalArticle

Open Access
Kidney Diseases
Serine
Chronic Renal Insufficiency
Kidney
Amino Acids

Serum d-serine accumulation after proximal renal tubular damage involves neutral amino acid transporter Asc-1

Suzuki, M., Gonda, Y., Yamada, M., Vandebroek, A. A., Mita, M., Hamase, K., Yasui, M. & Sasabe, J., Dec 1 2019, In : Scientific reports. 9, 1, 16705.

Research output: Contribution to journalArticle

Open Access
Neutral Amino Acid Transport Systems
Serine
Kidney
Serum
Cisplatin
Acridines
Chemiluminescence
Choline
Hydrogen peroxide
Hydrogen Peroxide

Three-Dimensional High-Performance Liquid Chromatographic Determination of Asn, Ser, Ala, and Pro Enantiomers in the Plasma of Patients with Chronic Kidney Disease

Furusho, A., Koga, R., Akita, T., Mita, M., Kimura, T. & Hamase, K., Sep 17 2019, In : Analytical chemistry. 91, 18, p. 11569-11575 7 p.

Research output: Contribution to journalArticle

Enantiomers
Plasmas
Amino Acids
Liquids
Plasma (human)
2018
8 Citations (Scopus)
Amino Acids
Fluids
Liquids
High Pressure Liquid Chromatography
L Forms
3 Citations (Scopus)
Plasma (human)
3-Hydroxybutyric Acid
High performance liquid chromatography
Lactic Acid
Enantiomers
1 Citation (Scopus)

Gut microbiota-derived D-serine protects against acute kidney injury

Nakade, Y., Iwata, Y., Furuichi, K., Mita, M., Hamase, K., Konno, R., Miyake, T., Sakai, N., Kitajima, S., Toyama, T., Shinozaki, Y., Sagara, A., Miyagawa, T., Hara, A., Shimizu, M., Kamikawa, Y., Sato, K., Oshima, M., Yoneda-Nakagawa, S., Yamamura, Y. & 8 others, Kaneko, S., Miyamoto, T., Katane, M., Homma, H., Morita, H., Suda, W., Hattori, M. & Wada, T., Oct 18 2018, In : JCI Insight. 3, 20

Research output: Contribution to journalArticle

Open Access
Acute Kidney Injury
Serine
Kidney
Amino Acids
Dysbiosis

Structural and enzymatic properties of mammalian D-glutamate cyclase

Katane, M., Ariyoshi, M., Tateishi, S., Koiwai, S., Takaku, K., Nagai, K., Nakayama, K., Saitoh, Y., Miyamoto, T., Sekine, M., Mita, M., Hamase, K., Matoba, S. & Homma, H., Sep 15 2018, In : Archives of Biochemistry and Biophysics. 654, p. 10-18 9 p.

Research output: Contribution to journalArticle

Proline
Glutamic Acid
Heart Failure
D-glutamate cyclase
Oligomerization
2017
19 Citations (Scopus)

D -Glutamate is metabolized in the heart mitochondria

Ariyoshi, M., Katane, M., Hamase, K., Miyoshi, Y., Nakane, M., Hoshino, A., Okawa, Y., Mita, Y., Kaimoto, S., Uchihashi, M., Fukai, K., Ono, K., Tateishi, S., Hato, D., Yamanaka, R., Honda, S., Fushimura, Y., Iwai-Kanai, E., Ishihara, N., Mita, M. & 2 others, Homma, H. & Matoba, S., Mar 7 2017, In : Scientific reports. 7, 43911.

Research output: Contribution to journalArticle

Heart Mitochondria
Glutamic Acid
glutamate racemase
Amino Acids
Proline
12 Citations (Scopus)

Heterogeneity of D-serine distribution in the human central nervous system

Suzuki, M., Imanishi, N., Mita, M., Hamase, K., Aiso, S. & Sasabe, J., May 1 2017, In : ASN Neuro. 9, 3

Research output: Contribution to journalArticle

Serine
Central Nervous System
Cerebrum
4 alpha-glucanotransferase
Neurophysiology
2016
47 Citations (Scopus)

Chiral amino acid metabolomics for novel biomarker screening in the prognosis of chronic kidney disease

Kimura, T., Hamase, K., Miyoshi, Y., Yamamoto, R., Yasuda, K., Mita, M., Rakugi, H., Hayashi, T. & Isaka, Y., May 18 2016, In : Scientific reports. 6, 26137.

Research output: Contribution to journalArticle

Metabolomics
Chronic Renal Insufficiency
Biomarkers
Amino Acids
Kidney Diseases
13 Citations (Scopus)

Enantioselective determination of citrulline and ornithine in the urine of D-amino acid oxidase deficient mice using a two-dimensional high-performance liquid chromatographic system

Koga, R., Miyoshi, Y., Sato, Y., Mita, M., Konno, R., Lindner, W. & Hamase, K., Oct 7 2016, In : Journal of Chromatography A. 1467, p. 312-317 6 p.

Research output: Contribution to journalArticle

D-Amino-Acid Oxidase
Citrulline
Ornithine
Enantiomers
Urine
30 Citations (Scopus)

Interplay between microbial d-amino acids and host d-amino acid oxidase modifies murine mucosal defence and gut microbiota

Sasabe, J., Miyoshi, Y., Rakoff-Nahoum, S., Zhang, T., Mita, M., Davis, B. M., Hamase, K. & Waldor, M. K., Jul 25 2016, In : Nature Microbiology. 1, 16125.

Research output: Contribution to journalArticle

Oxidoreductases
Amino Acids
Microbiota
Small Intestine
Gastrointestinal Microbiome
3 Citations (Scopus)

Participation of D-serine in the development and reproduction of the silkworm Bombyx mori

Tanigawa, M., Suzuki, C., Niwano, K., Kanekatsu, R., Tanaka, H., Horiike, K., Hamase, K. & Nagata, Y., Apr 1 2016, In : Journal of insect physiology. 87, p. 20-29 10 p.

Research output: Contribution to journalArticle

Bombyx
Bombyx mori
silkworms
serine
Serine
2015
23 Citations (Scopus)

Boronophenylalanine, a boron delivery agent for boron neutron capture therapy, is transported by ATB0,+, LAT1 and LAT2

Wongthai, P., Hagiwara, K., Miyoshi, Y., Wiriyasermkul, P., Wei, L., Ohgaki, R., Kato, I., Hamase, K., Nagamori, S. & Kanai, Y., Mar 1 2015, In : Cancer Science. 106, 3, p. 279-286 8 p.

Research output: Contribution to journalArticle

Neutron Capture Therapy
Amino Acid Transport Systems
Aromatic Amino Acids
Boron
Large Neutral Amino Acid-Transporter 1
23 Citations (Scopus)

Changes in d-aspartic acid and d-glutamic acid levels in the tissues and physiological fluids of mice with various d-aspartate oxidase activities

Han, H., Miyoshi, Y., Koga, R., Mita, M., Konno, R. & Hamase, K., Dec 10 2015, In : Journal of Pharmaceutical and Biomedical Analysis. 116, p. 47-52 6 p.

Research output: Contribution to journalArticle

Aspartic Acid
Glutamic Acid
Oxidoreductases
Tissue
Fluids
6 Citations (Scopus)

Design and synthesis of a novel pre-column derivatization reagent with a 6-methoxy-4-quinolone moiety for fluorescence and tandem mass spectrometric detection and its application to chiral amino acid analysis

Oyama, T., Negishi, E., Onigahara, H., Kusano, N., Miyoshi, Y., Mita, M., Nakazono, M., Ohtsuki, S., Ojida, A., Lindner, W. & Hamase, K., Dec 10 2015, In : Journal of Pharmaceutical and Biomedical Analysis. 116, p. 71-79 9 p.

Research output: Contribution to journalArticle

Fluorescence
Amino Acids
4-Quinolones
Electrospray ionization
Enantiomers
5 Citations (Scopus)

Development of a fully-automated on-line oxidation column-switching HPLC system for the determination of endogenous melatonin in human clinical samples

Oyama, T., Nagai, R., Fujimoto, M., Konishi, R., Mita, M., Uezono, K., Zaitsu, K. & Hamase, K., Jan 1 2015, In : analytical sciences. 31, 11, p. 1129-1135 7 p.

Research output: Contribution to journalArticle

Switching systems
Melatonin
Oxidation
Plasma (human)
Hydrogen Peroxide
5 Citations (Scopus)

Establishment of a two-dimensional chiral HPLC system for the simultaneous detection of lactate and 3-hydroxybutyrate enantiomers in human clinical samples

Liu, S. L., Oyama, T., Miyoshi, Y., Sheu, S. Y., Mita, M., Ide, T., Lindner, W., Hamase, K. & Lee, J. A., Dec 10 2015, In : Journal of Pharmaceutical and Biomedical Analysis. 116, p. 80-85 6 p.

Research output: Contribution to journalArticle

3-Hydroxybutyric Acid
Enantiomers
Lactic Acid
High Pressure Liquid Chromatography
formic acid
20 Citations (Scopus)

Glycolytic flux controls D-serine synthesis through glyceraldehyde-3-phosphate dehydrogenase in astrocytes

Suzuki, M., Sasabe, J., Miyoshi, Y., Kuwasako, K., Muto, Y., Hamase, K., Matsuoka, M., Imanishi, N. & Aiso, S., Apr 28 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 17, p. E2217-E2224

Research output: Contribution to journalArticle

Glyceraldehyde-3-Phosphate Dehydrogenases
Astrocytes
Serine
Hippocampus
Glycolysis
75 Citations (Scopus)

Lysocin e is a new antibiotic that targets menaquinone in the bacterial membrane

Hamamoto, H., Urai, M., Ishii, K., Yasukawa, J., Paudel, A., Murai, M., Kaji, T., Kuranaga, T., Hamase, K., Katsu, T., Su, J., Adachi, T., Uchida, R., Tomoda, H., Yamada, M., Souma, M., Kurihara, H., Inoue, M. & Sekimizu, K., Feb 1 2015, In : Nature Chemical Biology. 11, 2, p. 127-133 7 p.

Research output: Contribution to journalArticle

Vitamin K 2
Anti-Bacterial Agents
Membranes
Bombyx
Therapeutic Uses
29 Citations (Scopus)

Simultaneous analysis of D-alanine, D-aspartic acid, and D-serine using chiral high-performance liquid chromatography-tandem mass spectrometry and its application to the rat plasma and tissues

Karakawa, S., Shimbo, K., Yamada, N., Mizukoshi, T., Miyano, H., Mita, M., Lindner, W. & Hamase, K., Nov 1 2015, In : Journal of Pharmaceutical and Biomedical Analysis. 115, p. 123-129 7 p.

Research output: Contribution to journalArticle

D-Aspartic Acid
High performance liquid chromatography
Tandem Mass Spectrometry
Alanine
Serine
2014
9 Citations (Scopus)

Cellular origin and regulation of D- and L-serine in in vitro and in vivo models of cerebral ischemia

Abe, T., Suzuki, M., Sasabe, J., Takahashi, S., Unekawa, M., Mashima, K., Iizumi, T., Hamase, K., Konno, R., Aiso, S. & Suzuki, N., Dec 1 2014, In : Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 34, 12, p. 1928-1935 8 p.

Research output: Contribution to journalArticle

Brain Ischemia
Serine
Phosphoglycerate Dehydrogenase
N-Methyl-D-Aspartate Receptors
Neurons
18 Citations (Scopus)

Chiral amino acid analysis of Japanese traditional Kurozu and the developmental changes during earthenware jar fermentation processes

Miyoshi, Y., Nagano, M., Ishigo, S., Ito, Y., Hashiguchi, K., Hishida, N., Mita, M., Lindner, W. & Hamase, K., Sep 1 2014, In : Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences. 966, p. 187-192 6 p.

Research output: Contribution to journalArticle

Fermentation
Amino Acids
Enantiomers
Acetic Acid
High Pressure Liquid Chromatography
24 Citations (Scopus)

Ischemic acute kidney injury perturbs homeostasis of serine enantiomers in the body fluid in mice: Early detection of renal dysfunction using the ratio of serine enantiomers

Sasabe, J., Suzuki, M., Miyoshi, Y., Tojo, Y., Okamura, C., Ito, S., Konno, R., Mita, M., Hamase, K. & Aiso, S., Jan 29 2014, In : PloS one. 9, 1, e86504.

Research output: Contribution to journalArticle

Enantiomers
body fluids
Body fluids
enantiomers
Body Fluids
18 Citations (Scopus)

Localization of Serine Racemase and Its Role in the Skin

Inoue, R., Yoshihisa, Y., Tojo, Y., Okamura, C., Yoshida, Y., Kishimoto, J., Luan, X., Watanabe, M., Mizuguchi, M., Nabeshima, Y., Hamase, K., Matsunaga, K., Shimizu, T. & Mori, H., Jan 1 2014, In : Journal of Investigative Dermatology. 134, 6, p. 1618-1626 9 p.

Research output: Contribution to journalArticle

Keratinocytes
Skin
Epidermis
Serine
N-Methyl-D-Aspartate Receptors
2013
18 Citations (Scopus)
Mammals
Alanine
Oxidoreductases
Amino Acids
Liquids
2012
22 Citations (Scopus)

Alteration of intrinsic amounts of D-serine in the mice lacking serine racemase and D-amino acid oxidase

Miyoshi, Y., Konno, R., Sasabe, J., Ueno, K., Tojo, Y., Mita, M., Aiso, S. & Hamase, K., Nov 1 2012, In : Amino Acids. 43, 5, p. 1919-1931 13 p.

Research output: Contribution to journalArticle

D-Amino-Acid Oxidase
Serine
Brain
Tissue
Amino Acid Isomerases
108 Citations (Scopus)

D-Amino acid oxidase controls motoneuron degeneration through D-serine

Sasabe, J., Miyoshi, Y., Suzuki, M., Mita, M., Konno, R., Matsuoka, M., Hamase, K. & Aiso, S., Jan 10 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 2, p. 627-632 6 p.

Research output: Contribution to journalArticle

D-Amino-Acid Oxidase
Motor Neurons
Serine
Amyotrophic Lateral Sclerosis
Mitogen-Activated Protein Kinase Kinases

Development of a simultaneous two-dimensional micro-HPLC analysis system for the chiral amino acid metabolomics study in mammals

Miyoshi, Y., Tojo, Y., Han, H., Mita, M. & Hamase, K., Jan 1 2012, In : bunseki kagaku. 61, 6, p. 489-499 11 p.

Research output: Contribution to journalArticle

Mammals
Amino Acids
Enantiomers
Biomarkers
Animals
12 Citations (Scopus)

Enantioselective two-dimensional high-performance liquid chromatographic determination of N-methyl-d-aspartic acid and its analogues in mammals and bivalves

Koga, R., Miyoshi, Y., Negishi, E., Kaneko, T., Mita, M., Lindner, W. & Hamase, K., Dec 21 2012, In : Journal of Chromatography A. 1269, p. 255-261 7 p.

Research output: Contribution to journalArticle

Mammals
Bivalvia
Aspartic Acid
Enantiomers
Acids
26 Citations (Scopus)

Preliminary organic compound analysis of microparticles returned from Asteroid 25143 Itokawa by the Hayabusa mission

Naraoka, H., Mita, H., Hamase, K., Mita, M., Yabuta, H., Saito, K., Fukushima, K., Kitajima, F., Sandford, S. A., Nakamura, T., Noguchi, T., Okazaki, R., Nagao, K., Ebihara, M., Yurimoto, H., Tsuchiyama, A., Abe, M., Shirai, K., Ueno, M., Yada, T. & 6 others, Ishibashi, Y., Okada, T., Fujimura, A., Mukai, T., Yoshikawa, M. & Kawaguchi, J., Dec 1 2012, In : GEOCHEMICAL JOURNAL. 46, 1, p. 61-72 12 p.

Research output: Contribution to journalArticle

Asteroids
microparticles
asteroids
organic compounds
Organic compounds
9 Citations (Scopus)

Type 1 diabetes mellitus in mice increases hippocampal d-serine in the acute phase after streptozotocin injection

Suzuki, M., Sasabe, J., Furuya, S., Mita, M., Hamase, K. & Aiso, S., Jul 23 2012, In : Brain Research. 1466, p. 167-176 10 p.

Research output: Contribution to journalArticle

Streptozocin
Type 1 Diabetes Mellitus
Serine
Diabetes Mellitus
Injections
2011
91 Citations (Scopus)

D-Serine regulates cerebellar LTD and motor coordination through the δ glutamate receptor

Kakegawa, W., Miyoshi, Y., Hamase, K., Matsuda, S., Matsuda, K., Kohda, K., Emi, K., Motohashi, J., Konno, R., Zaitsu, K. & Yuzaki, M., May 1 2011, In : Nature Neuroscience. 14, 5, p. 603-613 11 p.

Research output: Contribution to journalArticle

Glutamate Receptors
Cerebellum
Serine
Neuronal Plasticity
Purkinje Cells
8 Citations (Scopus)

Enantioselective micro-2D-HPLC determination of aspartic acid in the pineal glands of rodents with various melatonin contents

Han, H., Miyoshi, Y., Oyama, T., Konishi, R., Mita, M. & Hamase, K., Oct 1 2011, In : Journal of Separation Science. 34, 20, p. 2847-2853 7 p.

Research output: Contribution to journalArticle

D-Aspartic Acid
Melatonin
Aspartic Acid
Acids
Rodentia
14 Citations (Scopus)
Alanine Racemase
Molting
Alanine
High Pressure Liquid Chromatography
Tissue
39 Citations (Scopus)

Simultaneous determination of d-aspartic acid and d-glutamic acid in rat tissues and physiological fluids using a multi-loop two-dimensional HPLC procedure

Han, H., Miyoshi, Y., Ueno, K., Okamura, C., Tojo, Y., Mita, M., Lindner, W., Zaitsu, K. & Hamase, K., Nov 1 2011, In : Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences. 879, 29, p. 3196-3202 7 p.

Research output: Contribution to journalArticle

Aspartic Acid
Rats
Glutamic Acid
Enantiomers
High Pressure Liquid Chromatography
39 Citations (Scopus)

Simultaneous two-dimensional HPLC determination of free d-serine and d-alanine in the brain and periphery of mutant rats lacking d-amino-acid oxidase

Miyoshi, Y., Hamase, K., Okamura, T., Konno, R., Kasai, N., Tojo, Y. & Zaitsu, K., Nov 1 2011, In : Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences. 879, 29, p. 3184-3189 6 p.

Research output: Contribution to journalArticle

Alanine
Serine
Rats
Brain
Oxidoreductases
2010
6 Citations (Scopus)

6,7-Difluoro-1,4-dihydro-1-methyl-4-oxo-3-quinolinecarboxylic acid, a newly designed fluorescence enhancement-type derivatizing reagent for amino compounds

Hirano, J., Hamase, K., Miyata, H. & Zaitsu, K., Mar 1 2010, In : Journal of Fluorescence. 20, 2, p. 615-624 10 p.

Research output: Contribution to journalArticle

Fluorescence
Derivatives
efficiency
Quantum efficiency
High Pressure Liquid Chromatography
64 Citations (Scopus)

Brain-specific Phgdh deletion reveals a pivotal role for l-serine biosynthesis in controlling the level of D-serine, an N-methyl-D-aspartate receptor co-agonist, in adult brain

Yang, J. H., Wada, A., Yoshida, K., Miyoshi, Y., Sayano, T., Esaki, K., Kinoshita, M. O., Tomonaga, S., Azuma, N., Watanabe, M., Hamase, K., Zaitsu, K., MacHida, T., Messing, A., Itohara, S., Hirabayashi, Y. & Furuya, S., Dec 31 2010, In : Journal of Biological Chemistry. 285, 53, p. 41380-41390 11 p.

Research output: Contribution to journalArticle

Biosynthesis
N-Methyl-D-Aspartate Receptors
Serine
Brain
Hippocampus
High pressure liquid chromatography
Stereoisomerism
Animals
Amino Acids
60 Citations (Scopus)

Simultaneous determination of hydrophilic amino acid enantiomers in mammalian tissues and physiological fluids applying a fully automated micro-two-dimensional high-performance liquid chromatographic concept

Hamase, K., Miyoshi, Y., Ueno, K., Han, H., Hirano, J., Morikawa, A., Mita, M., Kaneko, T., Lindner, W. & Zaitsu, K., Feb 12 2010, In : Journal of Chromatography A. 1217, 7, p. 1056-1062 7 p.

Research output: Contribution to journalArticle

Enantiomers
Tissue
Amino Acids
Fluids
Liquids
2009
78 Citations (Scopus)
High performance liquid chromatography
Alanine
Serine
Oxidoreductases
Fluorescence
21 Citations (Scopus)

Enantioselective visualization of D-alanine in rat anterior pituitary gland: Localization to ACTH-secreting cells

Etoh, S., Hamase, K., Morikawa, A., Ohgusu, T. & Zaitsu, K., Jan 1 2009, In : Analytical and Bioanalytical Chemistry. 393, 1, p. 217-223 7 p.

Research output: Contribution to journalArticle

Anterior Pituitary Gland
Alanine
Adrenocorticotropic Hormone
Rats
Visualization
5 Citations (Scopus)

Simple and rapid genotyping of D-amino acid oxidase gene recognizing a crucial variant in the ddY strain using microchip electrophoresis

Tojo, Y., Hamase, K., Konno, R., Satoru, K., Ohdo, S. & Zaitsu, K., Feb 1 2009, In : Journal of Separation Science. 32, 3, p. 430-436 7 p.

Research output: Contribution to journalArticle

D-Amino-Acid Oxidase
Electrophoresis
Amino acids
Genes
Amino Acids
2008
31 Citations (Scopus)

Automated and simultaneous two-dimensional micro-high-performance liquid chromatographic determination of proline and hydroxyproline enantiomers in mammals

Tojo, Y., Hamase, K., Nakata, M., Morikawa, A., Mita, M., Ashida, Y., Lindner, W. & Zaitsu, K., Nov 1 2008, In : Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences. 875, 1, p. 174-179 6 p.

Research output: Contribution to journalArticle

Mammals
Enantiomers
Hydroxyproline
Proline
Skin
18 Citations (Scopus)
Alanine
Rats
Habits
Mammals
Insulin
13 Citations (Scopus)

Structural and photophysical properties of novel dual fluorescent compounds, 1-aryl-substituted 6-methoxy-4-quinolones

Hirano, J., Hamase, K., Akita, T. & Zaitsu, K., Oct 1 2008, In : Luminescence. 23, 5, p. 350-355 6 p.

Research output: Contribution to journalArticle

Fluorescence
Acidity
X-Rays
X rays
Temperature
2007
77 Citations (Scopus)

A Genetic Variant of the Serine Racemase Gene Is Associated with Schizophrenia

Morita, Y., Ujike, H., Tanaka, Y., Otani, K., Kishimoto, M., Morio, A., Kotaka, T., Okahisa, Y., Matsushita, M., Morikawa, A., Hamase, K., Zaitsu, K. & Kuroda, S., May 15 2007, In : Biological Psychiatry. 61, 10, p. 1200-1203 4 p.

Research output: Contribution to journalArticle

Schizophrenia
Alleles
Serine
Genes
Single Nucleotide Polymorphism